locus-tag	class	description
TP50_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TP50_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TP50_RS00025	COG0187	DNA topoisomerase II activity
TP50_RS00035	COG0501	Belongs to the peptidase M48B family
TP50_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TP50_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_RS00125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TP50_RS00130	COG0793	Belongs to the peptidase S41A family
TP50_RS00135	COG4942	peptidase
TP50_RS00145	COG2234	aminopeptidase activity
TP50_RS00180	COG0493	'glutamate synthase
TP50_RS00185	COG0067	glutamate synthase
TP50_RS00185	COG0070	glutamate synthase
TP50_RS00185	COG0069	glutamate synthase activity
TP50_RS00275	COG1111	helicase
TP50_RS00275	COG1205	dead DEAH box helicase
TP50_RS00280	COG1272	protein, Hemolysin III
TP50_RS00300	COG0300	oxidoreductase activity
TP50_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS00360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP50_RS00370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP50_RS00380	COG1064	alcohol dehydrogenase
TP50_RS00415	COG0714	Associated with various cellular activities
TP50_RS00470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP50_RS00520	COG3237	CsbD-like
TP50_RS00550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TP50_RS00560	COG4772	TonB-dependent receptor
TP50_RS00575	COG1012	belongs to the aldehyde dehydrogenase family
TP50_RS00600	COG1304	FMN binding
TP50_RS00615	COG4585	Histidine kinase
TP50_RS00620	COG2197	response regulator
TP50_RS00640	COG3710	Transcriptional regulator
TP50_RS00645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TP50_RS00675	COG3039	Transposase
TP50_RS00695	COG0366	Alpha amylase catalytic
TP50_RS00700	COG0366	Alpha amylase catalytic
TP50_RS00705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP50_RS00735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TP50_RS00750	COG3507	Belongs to the glycosyl hydrolase 43 family
TP50_RS00755	COG1609	Transcriptional regulator
TP50_RS00770	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TP50_RS00775	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS00785	COG2755	lipolytic protein G-D-S-L family
TP50_RS00795	COG3186	Phenylalanine-4-hydroxylase
TP50_RS00800	COG1522	sequence-specific DNA binding
TP50_RS00810	COG1752	Esterase of the alpha-beta hydrolase superfamily
TP50_RS00820	COG1119	ATPase activity
TP50_RS00835	COG0517	IMP dehydrogenase activity
TP50_RS00835	COG1125	glycine betaine transport
TP50_RS00850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP50_RS00885	COG0489	protein tyrosine kinase activity
TP50_RS00890	COG2062	phosphohistidine phosphatase, SixA
TP50_RS00900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_RS00945	COG1968	undecaprenyl-diphosphatase activity
TP50_RS00955	COG0174	glutamine synthetase
TP50_RS00960	COG0347	Belongs to the P(II) protein family
TP50_RS00965	COG0004	ammonium transporteR
TP50_RS00970	COG3852	Histidine kinase
TP50_RS00975	COG2204	response regulator
TP50_RS00980	COG2032	superoxide dismutase activity
TP50_RS00985	COG2032	superoxide dismutase activity
TP50_RS00990	COG0346	lactoylglutathione lyase activity
TP50_RS01000	COG0183	Belongs to the thiolase family
TP50_RS01035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TP50_RS01040	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TP50_RS01045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TP50_RS01065	COG0028	Belongs to the TPP enzyme family
TP50_RS01070	COG2205	protein histidine kinase activity
TP50_RS01095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TP50_RS01110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_RS01120	COG0596	Alpha beta hydrolase
TP50_RS01125	COG0727	PFAM Uncharacterised protein family (UPF0153)
TP50_RS01130	COG0318	PFAM AMP-dependent synthetase and ligase
TP50_RS01145	COG3039	Transposase
TP50_RS01155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP50_RS01180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP50_RS01190	COG0564	pseudouridine synthase activity
TP50_RS01215	COG0339	signal peptide processing
TP50_RS01255	COG0475	glutathione-regulated potassium exporter activity
TP50_RS01260	COG0583	DNA-binding transcription factor activity
TP50_RS01265	COG3039	Transposase
TP50_RS01270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TP50_RS01275	COG2224	Isocitrate lyase
TP50_RS01300	COG3039	Transposase
TP50_RS01315	COG4770	biotin carboxylase activity
TP50_RS01320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TP50_RS01325	COG1960	acyl-CoA dehydrogenase activity
TP50_RS01395	COG0697	spore germination
TP50_RS01405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TP50_RS01410	COG1846	Transcriptional regulator
TP50_RS01415	COG1764	response to oxidative stress
TP50_RS01445	COG2130	NADP-dependent
TP50_RS01460	COG1187	pseudouridine synthase activity
TP50_RS01475	COG1643	Atp-dependent helicase
TP50_RS01480	COG4807	Protein conserved in bacteria
TP50_RS01485	COG2351	hydroxyisourate hydrolase activity
TP50_RS01490	COG2072	flavoprotein involved in K transport
TP50_RS01510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TP50_RS01520	COG0583	DNA-binding transcription factor activity
TP50_RS01555	COG2252	PERMEase
TP50_RS01580	COG0084	hydrolase, TatD family'
TP50_RS01590	COG0583	DNA-binding transcription factor activity
TP50_RS01595	COG2814	Major facilitator Superfamily
TP50_RS01605	COG2267	carboxylic ester hydrolase activity
TP50_RS01610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TP50_RS01615	COG1902	pentaerythritol trinitrate reductase activity
TP50_RS01635	COG0745	RESPONSE REGULATOR receiver
TP50_RS01640	COG2205	protein histidine kinase activity
TP50_RS01645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_RS01665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP50_RS01670	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP50_RS01675	COG0583	DNA-binding transcription factor activity
TP50_RS01710	COG0702	epimerase
TP50_RS01715	COG1733	regulation of RNA biosynthetic process
TP50_RS01765	COG0129	dihydroxy-acid dehydratase activity
TP50_RS01780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TP50_RS01835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TP50_RS01840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TP50_RS01865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TP50_RS01870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TP50_RS01880	COG3485	protocatechuate 3,4-dioxygenase
TP50_RS01885	COG3485	protocatechuate 3,4-dioxygenase
TP50_RS01895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP50_RS01900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TP50_RS01915	COG1414	Transcriptional regulator
TP50_RS01925	COG0657	acetylesterase activity
TP50_RS01935	COG0445	tRNA wobble uridine modification
TP50_RS01945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TP50_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS01975	COG2267	carboxylic ester hydrolase activity
TP50_RS01985	COG0156	8-amino-7-oxononanoate synthase activity
TP50_RS01990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TP50_RS01995	COG1040	competence protein
TP50_RS02000	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP50_RS02010	COG0582	viral genome integration into host DNA
TP50_RS02070	COG5297	Belongs to the glycosyl hydrolase family 6
TP50_RS02120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TP50_RS02175	COG3039	Transposase
TP50_RS02205	COG3264	Mechanosensitive ion channel
TP50_RS02205	COG1511	domain protein
TP50_RS02210	COG1368	sulfuric ester hydrolase activity
TP50_RS02220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP50_RS02225	COG2354	Protein conserved in bacteria
TP50_RS02235	COG0297	glycogen (starch) synthase activity
TP50_RS02240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP50_RS02245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP50_RS02270	COG0702	epimerase
TP50_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS02325	COG0513	Belongs to the DEAD box helicase family
TP50_RS02330	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP50_RS02345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TP50_RS02355	COG3483	tryptophan 2,3-dioxygenase activity
TP50_RS02360	COG3104	oligopeptide transport
TP50_RS02380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TP50_RS02390	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TP50_RS02410	COG1320	monovalent cation:proton antiporter activity
TP50_RS02415	COG2212	antiporter activity
TP50_RS02425	COG0651	ATP synthesis coupled electron transport
TP50_RS02430	COG1006	Multisubunit Na H antiporter MnhC subunit
TP50_RS02435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP50_RS02435	COG2111	Na H antiporter
TP50_RS02460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TP50_RS02465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TP50_RS02480	COG0456	acetyltransferase
TP50_RS02485	COG1597	lipid kinase activity
TP50_RS02510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TP50_RS02515	COG0134	indole-3-glycerol-phosphate synthase activity
TP50_RS02525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP50_RS02530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TP50_RS02540	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TP50_RS02550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TP50_RS02565	COG1051	belongs to the nudix hydrolase family
TP50_RS02605	COG0316	Belongs to the HesB IscA family
TP50_RS02625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP50_RS02645	COG2814	Major facilitator Superfamily
TP50_RS02655	COG2814	Major facilitator Superfamily
TP50_RS02660	COG1289	transmembrane transporter activity
TP50_RS02665	COG0151	Belongs to the GarS family
TP50_RS02675	COG0138	bifunctional purine biosynthesis protein purh
TP50_RS02680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP50_RS02685	COG2267	carboxylic ester hydrolase activity
TP50_RS02690	COG0671	phosphoesterase, PA-phosphatase related
TP50_RS02690	COG2453	phosphatase
TP50_RS02715	COG4589	Belongs to the CDS family
TP50_RS02720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TP50_RS02745	COG2264	protein methyltransferase activity
TP50_RS02765	COG0439	Biotin carboxylase
TP50_RS02775	COG0511	ligase activity, forming carbon-carbon bonds
TP50_RS02780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TP50_RS02790	COG1324	tolerance protein
TP50_RS02810	COG0459	protein refolding
TP50_RS02825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TP50_RS02840	COG3386	PFAM SMP-30 Gluconolaconase
TP50_RS02850	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TP50_RS02870	COG3039	Transposase
TP50_RS02910	COG0778	Nitroreductase
TP50_RS02915	COG2353	YceI-like domain
TP50_RS02945	COG3052	prosthetic group binding
TP50_RS02980	COG1802	Transcriptional regulator
TP50_RS03020	COG3039	Transposase
TP50_RS03035	COG3039	Transposase
TP50_RS03070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TP50_RS03080	COG0025	NhaP-type Na H and K H
TP50_RS03085	COG1131	(ABC) transporter
TP50_RS03090	COG0842	Transport permease protein
TP50_RS03145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_RS03150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TP50_RS03170	COG2202	Pas domain
TP50_RS03170	COG2205	protein histidine kinase activity
TP50_RS03190	COG2813	Specifically methylates the guanine in position
TP50_RS03195	COG1187	pseudouridine synthase activity
TP50_RS03200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP50_RS03235	COG1666	GTP binding
TP50_RS03240	COG0697	spore germination
TP50_RS03245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TP50_RS03250	COG2011	ABC-type metal ion transport system permease component
TP50_RS03295	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP50_RS03305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP50_RS03325	COG0356	it plays a direct role in the translocation of protons across the membrane
TP50_RS03335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TP50_RS03340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TP50_RS03345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TP50_RS03350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TP50_RS03355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TP50_RS03360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TP50_RS03375	COG3039	Transposase
TP50_RS03385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TP50_RS03390	COG4191	Histidine kinase
TP50_RS03405	COG0577	efflux transmembrane transporter activity
TP50_RS03405	COG1136	(ABC) transporter
TP50_RS03415	COG1136	(ABC) transporter
TP50_RS03420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_RS03425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP50_RS03475	COG0339	signal peptide processing
TP50_RS03480	COG3039	Transposase
TP50_RS03495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP50_RS03500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TP50_RS03505	COG0546	phosphoglycolate phosphatase activity
TP50_RS03515	COG2819	hydrolase of the alpha beta superfamily
TP50_RS03525	COG1956	GAF domain-containing protein
TP50_RS03530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TP50_RS03540	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TP50_RS03555	COG0720	synthase
TP50_RS03565	COG4771	TonB-dependent receptor
TP50_RS03580	COG0513	Belongs to the DEAD box helicase family
TP50_RS03595	COG0625	glutathione transferase activity
TP50_RS03625	COG0626	cystathionine gamma-synthase activity
TP50_RS03635	COG0438	transferase activity, transferring glycosyl groups
TP50_RS03655	COG0438	transferase activity, transferring glycosyl groups
TP50_RS03660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TP50_RS03680	COG2801	Transposase and inactivated derivatives
TP50_RS03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP50_RS03705	COG0277	FAD linked oxidase domain protein
TP50_RS03710	COG0546	phosphoglycolate phosphatase activity
TP50_RS03710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP50_RS03725	COG2086	electron transfer activity
TP50_RS03760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TP50_RS03760	COG0662	Cupin 2, conserved barrel domain protein
TP50_RS03765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP50_RS03795	COG3218	ABC-type transport auxiliary lipoprotein component
TP50_RS03795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP50_RS03800	COG1127	ABC transporter
TP50_RS03805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP50_RS03825	COG0442	prolyl-tRNA aminoacylation
TP50_RS03835	COG1183	phosphatidylcholine synthase activity
TP50_RS03865	COG3039	Transposase
TP50_RS03880	COG0525	valine-tRNA ligase activity
TP50_RS03895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP50_RS03905	COG0795	lipopolysaccharide-transporting ATPase activity
TP50_RS03920	COG4974	Belongs to the 'phage' integrase family
TP50_RS03935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP50_RS03950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TP50_RS03950	COG0047	phosphoribosylformylglycinamidine synthase activity
TP50_RS04035	COG0251	oxidation-reduction process
TP50_RS04110	COG1063	alcohol dehydrogenase
TP50_RS04125	COG1132	(ABC) transporter
TP50_RS04145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TP50_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS04165	COG1294	oxidase, subunit
TP50_RS04170	COG1271	oxidase subunit
TP50_RS04175	COG3039	Transposase
TP50_RS04180	COG5295	Hep Hag repeat protein
TP50_RS04185	COG1404	Belongs to the peptidase S8 family
TP50_RS04190	COG5295	Hep Hag repeat protein
TP50_RS04195	COG1404	Belongs to the peptidase S8 family
TP50_RS04200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP50_RS04210	COG1459	type II secretion system
TP50_RS04215	COG2165	general secretion pathway protein
TP50_RS04220	COG4970	Tfp pilus assembly protein FimT
TP50_RS04225	COG2165	general secretion pathway protein
TP50_RS04230	COG4795	General secretion pathway protein
TP50_RS04235	COG3156	type II secretion system protein K
TP50_RS04240	COG3166	PFAM Fimbrial assembly family protein
TP50_RS04255	COG1450	Type ii and iii secretion system protein
TP50_RS04265	COG2188	Transcriptional regulator
TP50_RS04350	COG1215	transferase activity, transferring glycosyl groups
TP50_RS04355	COG1215	transferase activity, transferring glycosyl groups
TP50_RS04365	COG0457	Tetratricopeptide repeat
TP50_RS04390	COG0242	peptide deformylase activity
TP50_RS04395	COG1307	EDD domain protein, DegV family
TP50_RS04420	COG0402	S-adenosylhomocysteine deaminase activity
TP50_RS04425	COG3964	amidohydrolase
TP50_RS04440	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP50_RS04445	COG0726	polysaccharide deacetylase
TP50_RS04460	COG0436	Aminotransferase
TP50_RS04475	COG3039	Transposase
TP50_RS04485	COG3039	Transposase
TP50_RS04495	COG3039	Transposase
TP50_RS04500	COG3039	Transposase
TP50_RS04505	COG1162	GTPase activity
TP50_RS04535	COG2211	Major facilitator Superfamily
TP50_RS04540	COG1609	Transcriptional regulator
TP50_RS04545	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS04550	COG2851	Citrate transporter
TP50_RS04570	COG0642	Histidine kinase
TP50_RS04585	COG2197	response regulator
TP50_RS04600	COG0667	Aldo Keto reductase
TP50_RS04610	COG0583	DNA-binding transcription factor activity
TP50_RS04635	COG1301	dicarboxylic acid transport
TP50_RS04640	COG0281	malic enzyme
TP50_RS04640	COG0280	phosphate acetyltransferase
TP50_RS04665	COG1560	Kdo2-lipid A biosynthetic process
TP50_RS04670	COG1519	Transferase
TP50_RS04675	COG1538	Outer membrane efflux protein
TP50_RS04680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP50_RS04700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TP50_RS04705	COG0066	3-isopropylmalate dehydratase activity
TP50_RS04710	COG0473	3-isopropylmalate dehydrogenase activity
TP50_RS04720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TP50_RS04740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TP50_RS04745	COG0405	Gamma-glutamyltransferase
TP50_RS04750	COG0840	transmembrane signaling receptor activity
TP50_RS04765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TP50_RS04770	COG3710	Transcriptional regulator
TP50_RS04790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TP50_RS04800	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TP50_RS04810	COG3039	Transposase
TP50_RS04820	COG0563	adenylate kinase activity
TP50_RS04825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP50_RS04835	COG3781	membrane
TP50_RS04840	COG0671	phosphoesterase, PA-phosphatase related
TP50_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS04855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP50_RS04860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TP50_RS04890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP50_RS04905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP50_RS04925	COG0352	thiamine-phosphate diphosphorylase activity
TP50_RS04930	COG1773	rubredoxin
TP50_RS04935	COG2912	Transglutaminase-like superfamily
TP50_RS04945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TP50_RS04955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TP50_RS04975	COG3079	Belongs to the UPF0149 family
TP50_RS04980	COG0006	proline dipeptidase activity
TP50_RS04985	COG0006	proline dipeptidase activity
TP50_RS05000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TP50_RS05005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TP50_RS05015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TP50_RS05020	COG1561	YicC-like family, N-terminal region
TP50_RS05035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP50_RS05040	COG0583	DNA-binding transcription factor activity
TP50_RS05055	COG2271	Major facilitator Superfamily
TP50_RS05070	COG2721	sulfolactate sulfo-lyase activity
TP50_RS05080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TP50_RS05095	COG0372	Belongs to the citrate synthase family
TP50_RS05105	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TP50_RS05140	COG0714	Associated with various cellular activities
TP50_RS05160	COG2304	oxidoreductase activity
TP50_RS05170	COG1301	dicarboxylic acid transport
TP50_RS05175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TP50_RS05185	COG4773	Receptor
TP50_RS05190	COG0739	heme binding
TP50_RS05195	COG1376	ErfK ybiS ycfS ynhG family protein
TP50_RS05230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TP50_RS05235	COG4149	molybdate abc transporter
TP50_RS05240	COG0725	ABC transporter, periplasmic molybdate-binding protein
TP50_RS05245	COG3453	Protein conserved in bacteria
TP50_RS05245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_RS05255	COG3047	cAMP biosynthetic process
TP50_RS05260	COG3047	cAMP biosynthetic process
TP50_RS05270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TP50_RS05290	COG0126	phosphoglycerate kinase activity
TP50_RS05300	COG0469	pyruvate kinase activity
TP50_RS05315	COG3588	fructose-bisphosphate aldolase
TP50_RS05320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TP50_RS05335	COG1648	precorrin-2 dehydrogenase activity
TP50_RS05335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TP50_RS05355	COG0784	Response regulator, receiver
TP50_RS05355	COG2198	Histidine kinase
TP50_RS05355	COG2205	protein histidine kinase activity
TP50_RS05375	COG0175	sulfate reduction
TP50_RS05380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TP50_RS05385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP50_RS05390	COG0175	sulfate reduction
TP50_RS05395	COG2895	sulfate adenylyltransferase (ATP) activity
TP50_RS05395	COG0529	Catalyzes the synthesis of activated sulfate
TP50_RS05405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_RS05410	COG0308	aminopeptidase N
TP50_RS05420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP50_RS05430	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_RS05435	COG3250	beta-galactosidase activity
TP50_RS05445	COG1609	Transcriptional regulator
TP50_RS05455	COG1970	mechanosensitive ion channel activity
TP50_RS05480	COG3273	potassium ion transport
TP50_RS05480	COG0471	metal ion transport
TP50_RS05485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TP50_RS05490	COG2022	thiamine diphosphate biosynthetic process
TP50_RS05520	COG3039	Transposase
TP50_RS05525	COG3039	Transposase
TP50_RS05545	COG3039	Transposase
TP50_RS05560	COG0189	ligase activity
TP50_RS05570	COG0745	RESPONSE REGULATOR receiver
TP50_RS05605	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TP50_RS05610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TP50_RS05615	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TP50_RS05620	COG2205	protein histidine kinase activity
TP50_RS05625	COG0745	RESPONSE REGULATOR receiver
TP50_RS05630	COG0277	FAD linked oxidase domain protein
TP50_RS05635	COG1988	membrane-bound metal-dependent
TP50_RS05640	COG0792	nuclease activity
TP50_RS05670	COG0275	rRNA processing
TP50_RS05675	COG3116	cell division
TP50_RS05685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TP50_RS05690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TP50_RS05695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP50_RS05705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TP50_RS05710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP50_RS05715	COG1181	Belongs to the D-alanine--D-alanine ligase family
TP50_RS05720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TP50_RS05735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TP50_RS05745	COG0739	heme binding
TP50_RS05750	COG0653	protein targeting
TP50_RS05755	COG0494	nUDIX hydrolase
TP50_RS05765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP50_RS05780	COG3321	synthase
TP50_RS05780	COG0604	alcohol dehydrogenase
TP50_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS05805	COG0366	Alpha amylase catalytic
TP50_RS05840	COG2226	methyltransferase
TP50_RS05845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TP50_RS05920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TP50_RS05930	COG4106	trans-aconitate 2-methyltransferase activity
TP50_RS05935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP50_RS05945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP50_RS05950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TP50_RS05960	COG0667	Aldo Keto reductase
TP50_RS05970	COG3039	Transposase
TP50_RS05975	COG4771	TonB-dependent receptor
TP50_RS05995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP50_RS06000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TP50_RS06010	COG2175	clavaminate synthase activity
TP50_RS06020	COG4181	ATPase activity
TP50_RS06035	COG0642	Histidine kinase
TP50_RS06045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TP50_RS06065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TP50_RS06070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TP50_RS06085	COG3829	transcription factor binding
TP50_RS06095	COG1116	anion transmembrane transporter activity
TP50_RS06100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP50_RS06110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP50_RS06115	COG0431	NADPH-dependent FMN reductase
TP50_RS06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TP50_RS06165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TP50_RS06170	COG2967	ApaG domain
TP50_RS06175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TP50_RS06180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TP50_RS06230	COG1196	nuclear chromosome segregation
TP50_RS06265	COG0758	DNA mediated transformation
TP50_RS06270	COG1652	LysM domain
TP50_RS06275	COG0242	peptide deformylase activity
TP50_RS06280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TP50_RS06285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP50_RS06285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TP50_RS06340	COG1560	Kdo2-lipid A biosynthetic process
TP50_RS06345	COG1490	D-aminoacyl-tRNA deacylase activity
TP50_RS06350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP50_RS06410	COG1396	sequence-specific DNA binding
TP50_RS06470	COG0305	Participates in initiation and elongation during chromosome replication
TP50_RS06490	COG3657	addiction module killer protein
TP50_RS06510	COG3179	chitinase
TP50_RS06555	COG1802	Transcriptional regulator
TP50_RS06555	COG4626	Terminase
TP50_RS06690	COG0582	viral genome integration into host DNA
TP50_RS06705	COG3039	Transposase
TP50_RS06720	COG2204	response regulator
TP50_RS06755	COG3546	catalase activity
TP50_RS06760	COG3685	Protein conserved in bacteria
TP50_RS06785	COG2972	Histidine kinase
TP50_RS06800	COG0531	amino acid
TP50_RS06815	COG3590	peptidase
TP50_RS06830	COG0667	Aldo Keto reductase
TP50_RS06840	COG0583	DNA-binding transcription factor activity
TP50_RS06850	COG3384	dioxygenase
TP50_RS06860	COG1573	uracil-dna glycosylase
TP50_RS06890	COG4221	oxidoreductase activity
TP50_RS06900	COG0435	Glutathione S-transferase
TP50_RS06930	COG1506	peptidase
TP50_RS06930	COG0823	Involved in the tonB-independent uptake of proteins
TP50_RS06970	COG0697	spore germination
TP50_RS06975	COG3039	Transposase
TP50_RS06995	COG1113	amino acid transport
TP50_RS07005	COG3039	Transposase
TP50_RS07025	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TP50_RS07090	COG3039	Transposase
TP50_RS07100	COG0840	transmembrane signaling receptor activity
TP50_RS07110	COG0659	secondary active sulfate transmembrane transporter activity
TP50_RS07135	COG2943	transferase activity, transferring hexosyl groups
TP50_RS07145	COG3275	phosphorelay sensor kinase activity
TP50_RS07155	COG0181	hydroxymethylbilane synthase activity
TP50_RS07185	COG1505	serine-type exopeptidase activity
TP50_RS07190	COG0436	Aminotransferase
TP50_RS07200	COG2832	Protein of unknown function (DUF454)
TP50_RS07210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TP50_RS07220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TP50_RS07225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TP50_RS07230	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TP50_RS07255	COG2226	methyltransferase
TP50_RS07265	COG0308	aminopeptidase N
TP50_RS07295	COG2010	Cytochrome c
TP50_RS07315	COG3284	Transcriptional regulator
TP50_RS07320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP50_RS07325	COG1077	Cell shape determining protein MreB Mrl
TP50_RS07330	COG1792	Involved in formation and maintenance of cell shape
TP50_RS07345	COG0772	Belongs to the SEDS family
TP50_RS07355	COG2951	lytic endotransglycosylase activity
TP50_RS07360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TP50_RS07370	COG1686	Belongs to the peptidase S11 family
TP50_RS07380	COG2921	Belongs to the UPF0250 family
TP50_RS07385	COG0321	lipoyl(octanoyl) transferase activity
TP50_RS07390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TP50_RS07405	COG0583	DNA-binding transcription factor activity
TP50_RS07415	COG1056	cytidyltransferase-related domain
TP50_RS07415	COG1051	belongs to the nudix hydrolase family
TP50_RS07450	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TP50_RS07455	COG0673	inositol 2-dehydrogenase activity
TP50_RS07460	COG2823	Periplasmic or secreted lipoprotein
TP50_RS07465	COG4251	negative regulation of phosphorylation
TP50_RS07470	COG0784	Response regulator, receiver
TP50_RS07475	COG4191	Histidine kinase
TP50_RS07480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TP50_RS07535	COG1459	type II secretion system
TP50_RS07540	COG2165	general secretion pathway protein
TP50_RS07555	COG4795	General secretion pathway protein
TP50_RS07595	COG3250	beta-galactosidase activity
TP50_RS07610	COG2188	Transcriptional regulator
TP50_RS07620	COG1609	Transcriptional regulator
TP50_RS07625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP50_RS07630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TP50_RS07645	COG0617	tRNA 3'-terminal CCA addition
TP50_RS07660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TP50_RS07665	COG1012	belongs to the aldehyde dehydrogenase family
TP50_RS07670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TP50_RS07685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP50_RS07700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TP50_RS07705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP50_RS07725	COG2205	protein histidine kinase activity
TP50_RS07755	COG3791	Glutathione-dependent formaldehyde-activating
TP50_RS07770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP50_RS07780	COG0697	spore germination
TP50_RS07790	COG0488	(ABC) transporter
TP50_RS07800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TP50_RS07805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TP50_RS07815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP50_RS07815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP50_RS07835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TP50_RS07840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP50_RS07845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TP50_RS07870	COG3039	Transposase
TP50_RS07880	COG3209	COG3209 Rhs family protein
TP50_RS07885	COG0237	dephospho-CoA kinase activity
TP50_RS07890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TP50_RS07895	COG1459	type II secretion system
TP50_RS07930	COG0045	succinate-CoA ligase (ADP-forming) activity
TP50_RS07935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TP50_RS07945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TP50_RS07945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP50_RS07955	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_RS07960	COG0564	pseudouridine synthase activity
TP50_RS07975	COG3011	Protein conserved in bacteria
TP50_RS07980	COG0840	transmembrane signaling receptor activity
TP50_RS08000	COG3387	PFAM Glycoside hydrolase 15-related
TP50_RS08005	COG1877	trehalose-phosphatase activity
TP50_RS08045	COG2827	Endonuclease containing a URI domain
TP50_RS08050	COG4771	TonB-dependent receptor
TP50_RS08055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP50_RS08060	COG0667	Aldo Keto reductase
TP50_RS08065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TP50_RS08070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP50_RS08075	COG1116	anion transmembrane transporter activity
TP50_RS08080	COG0542	response to heat
TP50_RS08085	COG4206	TonB-dependent receptor
TP50_RS08110	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP50_RS08120	COG1492	cobalamin metabolic process
TP50_RS08130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TP50_RS08170	COG0019	diaminopimelate decarboxylase activity
TP50_RS08185	COG4264	IucA IucC family
TP50_RS08195	COG4772	TonB-dependent receptor
TP50_RS08205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP50_RS08205	COG4651	solute:proton antiporter activity
TP50_RS08245	COG0488	(ABC) transporter
TP50_RS08285	COG3039	Transposase
TP50_RS08290	COG0477	Major facilitator Superfamily
TP50_RS08305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TP50_RS08320	COG0217	transcriptional regulatory protein
TP50_RS08325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TP50_RS08330	COG0632	four-way junction helicase activity
TP50_RS08335	COG3158	transport of potassium into the cell
TP50_RS08340	COG2255	four-way junction helicase activity
TP50_RS08345	COG0824	Thioesterase
TP50_RS08355	COG0848	biopolymer transport protein
TP50_RS08365	COG0823	Involved in the tonB-independent uptake of proteins
TP50_RS08370	COG2885	chlorophyll binding
TP50_RS08380	COG0602	queuosine metabolic process
TP50_RS08390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TP50_RS08395	COG3920	Histidine kinase
TP50_RS08415	COG0840	transmembrane signaling receptor activity
TP50_RS08460	COG0514	ATP-dependent DNA helicase (RecQ)
TP50_RS08465	COG0783	Belongs to the Dps family
TP50_RS08470	COG1643	Atp-dependent helicase
TP50_RS08485	COG0837	glucose binding
TP50_RS08505	COG0535	radical SAM domain protein
TP50_RS08510	COG0535	radical SAM domain protein
TP50_RS08515	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TP50_RS08520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TP50_RS08530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP50_RS08545	COG1215	transferase activity, transferring glycosyl groups
TP50_RS08550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP50_RS08560	COG1199	ATP-dependent helicase activity
TP50_RS08570	COG1397	ADP-ribosylglycohydrolase
TP50_RS08580	COG0189	ligase activity
TP50_RS08595	COG0835	chemotaxis
TP50_RS08600	COG0840	transmembrane signaling receptor activity
TP50_RS08605	COG2198	Histidine kinase
TP50_RS08605	COG0643	Histidine kinase
TP50_RS08605	COG0784	Response regulator, receiver
TP50_RS08630	COG1446	asparaginase
TP50_RS08635	COG3142	Participates in the control of copper homeostasis
TP50_RS08690	COG3537	Alpha-1,2-mannosidase
TP50_RS08700	COG1486	melibiose metabolic process
TP50_RS08710	COG0531	amino acid
TP50_RS08725	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_RS08740	COG3858	chitin binding
TP50_RS08740	COG1388	LysM domain
TP50_RS08755	COG0837	glucose binding
TP50_RS08760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TP50_RS08770	COG0494	nUDIX hydrolase
TP50_RS08775	COG1218	3'(2'),5'-bisphosphate nucleotidase
TP50_RS08780	COG3956	TIGRFAM MazG family protein
TP50_RS08785	COG1742	UPF0060 membrane protein
TP50_RS08800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TP50_RS08805	COG0509	glycine decarboxylation via glycine cleavage system
TP50_RS08835	COG1960	acyl-CoA dehydrogenase activity
TP50_RS08845	COG1309	transcriptional regulator
TP50_RS08855	COG4771	TonB-dependent receptor
TP50_RS08865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TP50_RS08870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP50_RS08875	COG0463	Glycosyl transferase, family 2
TP50_RS08880	COG0517	IMP dehydrogenase activity
TP50_RS08880	COG0516	GMP reductase activity
TP50_RS08885	COG2982	Protein involved in outer membrane biogenesis
TP50_RS08890	COG1272	protein, Hemolysin III
TP50_RS08895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TP50_RS08900	COG0739	heme binding
TP50_RS08905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP50_RS08910	COG0626	cystathionine gamma-synthase activity
TP50_RS08915	COG0527	aspartate kinase activity
TP50_RS08915	COG0460	homoserine dehydrogenase
TP50_RS08930	COG1760	l-serine dehydratase
TP50_RS08950	COG2353	YceI-like domain
TP50_RS08955	COG2198	Histidine kinase
TP50_RS08955	COG0784	Response regulator, receiver
TP50_RS08955	COG2205	protein histidine kinase activity
TP50_RS08960	COG0784	Response regulator, receiver
TP50_RS08960	COG2198	Histidine kinase
TP50_RS08960	COG5002	protein histidine kinase activity
TP50_RS08970	COG0745	RESPONSE REGULATOR receiver
TP50_RS08970	COG3292	Two component regulator propeller
TP50_RS08970	COG2205	protein histidine kinase activity
TP50_RS08975	COG3039	Transposase
TP50_RS08990	COG2814	Major facilitator Superfamily
TP50_RS08995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TP50_RS09005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TP50_RS09010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TP50_RS09015	COG0259	pyridoxamine-phosphate oxidase activity
TP50_RS09025	COG1842	Phage shock protein A
TP50_RS09050	COG0754	glutathionylspermidine amidase activity
TP50_RS09065	COG2814	Major facilitator Superfamily
TP50_RS09185	COG0531	amino acid
TP50_RS09190	COG2197	response regulator
TP50_RS09220	COG1113	amino acid transport
TP50_RS09230	COG1271	oxidase subunit
TP50_RS09235	COG1294	oxidase, subunit
TP50_RS09245	COG2239	Acts as a magnesium transporter
TP50_RS09255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP50_RS09260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP50_RS09270	COG1660	Displays ATPase and GTPase activities
TP50_RS09275	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TP50_RS09280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP50_RS09295	COG1137	ATPase activity
TP50_RS09300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TP50_RS09310	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TP50_RS09320	COG0271	Belongs to the BolA IbaG family
TP50_RS09325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TP50_RS09345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TP50_RS09355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TP50_RS09365	COG0628	permease
TP50_RS09390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TP50_RS09395	COG3178	'Phosphotransferase
TP50_RS09410	COG1555	photosystem II stabilization
TP50_RS09430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP50_RS09440	COG3039	Transposase
TP50_RS09460	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP50_RS09460	COG1024	Enoyl-CoA hydratase
TP50_RS09475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP50_RS09480	COG0481	GTPase activity
TP50_RS09495	COG0571	ribonuclease III activity
TP50_RS09500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TP50_RS09505	COG1381	Involved in DNA repair and RecF pathway recombination
TP50_RS09515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP50_RS09520	COG3039	Transposase
TP50_RS09525	COG2954	triphosphatase activity
TP50_RS09530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TP50_RS09535	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TP50_RS09540	COG3046	protein related to deoxyribodipyrimidine photolyase
TP50_RS09545	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_RS09550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TP50_RS09555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TP50_RS09560	COG1278	Cold shock
TP50_RS09565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_RS09575	COG1201	RNA secondary structure unwinding
TP50_RS09580	COG1793	dna ligase
TP50_RS09590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP50_RS09590	COG1793	dna ligase
TP50_RS09620	COG0183	Belongs to the thiolase family
TP50_RS09640	COG1451	nucleotide metabolic process
TP50_RS09645	COG5487	UPF0391 membrane protein
TP50_RS09655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TP50_RS09680	COG1047	Peptidyl-prolyl cis-trans
TP50_RS09690	COG2824	Alkylphosphonate utilization operon protein PhnA
TP50_RS09700	COG1902	pentaerythritol trinitrate reductase activity
TP50_RS09705	COG2814	Major facilitator Superfamily
TP50_RS09740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TP50_RS09740	COG0392	lysyltransferase activity
TP50_RS09750	COG0251	oxidation-reduction process
TP50_RS09755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP50_RS09770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP50_RS09795	COG1595	DNA-templated transcription, initiation
TP50_RS09840	COG5449	Phage conserved hypothetical protein BR0599
TP50_RS09850	COG1196	nuclear chromosome segregation
TP50_RS09890	COG2878	Part of a membrane complex involved in electron transport
TP50_RS09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP50_RS09900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP50_RS09915	COG1131	(ABC) transporter
TP50_RS09920	COG0346	lactoylglutathione lyase activity
TP50_RS09925	COG0833	amino acid
TP50_RS09930	COG2040	homocysteine
TP50_RS09940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TP50_RS09965	COG1695	Transcriptional regulator
TP50_RS09985	COG1981	membrane
TP50_RS10005	COG4584	PFAM Integrase catalytic
TP50_RS10010	COG1484	DNA-dependent DNA replication
TP50_RS10020	COG0825	malonyl-CoA metabolic process
TP50_RS10035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_RS10040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_RS10045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP50_RS10050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_RS10065	COG0750	zinc metalloprotease
TP50_RS10070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TP50_RS10075	COG0575	Belongs to the CDS family
TP50_RS10080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TP50_RS10085	COG0233	cytoplasmic translational termination
TP50_RS10090	COG0528	UMP kinase activity
TP50_RS10100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TP50_RS10105	COG0052	Belongs to the universal ribosomal protein uS2 family
TP50_RS10140	COG3039	Transposase
TP50_RS10150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TP50_RS10160	COG1393	Belongs to the ArsC family
TP50_RS10165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TP50_RS10170	COG0367	asparagine synthase
TP50_RS10180	COG4774	siderophore transport
TP50_RS10195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP50_RS10220	COG1566	PFAM secretion protein HlyD family protein
TP50_RS10225	COG2814	Major facilitator Superfamily
TP50_RS10275	COG0339	signal peptide processing
TP50_RS10285	COG0386	Belongs to the glutathione peroxidase family
TP50_RS10295	COG0386	Belongs to the glutathione peroxidase family
TP50_RS10310	COG3039	Transposase
TP50_RS10360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TP50_RS10365	COG0084	hydrolase, TatD family'
TP50_RS10380	COG1960	acyl-CoA dehydrogenase activity
TP50_RS10400	COG0367	asparagine synthase
TP50_RS10410	COG0305	Participates in initiation and elongation during chromosome replication
TP50_RS10415	COG0415	Belongs to the DNA photolyase family
TP50_RS10430	COG0583	DNA-binding transcription factor activity
TP50_RS10475	COG3706	GGDEF domain
TP50_RS10500	COG3039	Transposase
TP50_RS10525	COG0753	catalase activity
TP50_RS10530	COG0656	L-ascorbic acid biosynthetic process
TP50_RS10540	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP50_RS10540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP50_RS10545	COG2814	Major facilitator Superfamily
TP50_RS10560	COG2194	sulfuric ester hydrolase activity
TP50_RS10575	COG0745	RESPONSE REGULATOR receiver
TP50_RS10580	COG0642	Histidine kinase
TP50_RS10590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TP50_RS10595	COG2894	cell division
TP50_RS10600	COG0850	regulation of cytokinetic process
TP50_RS10615	COG4585	Histidine kinase
TP50_RS10620	COG2197	response regulator
TP50_RS10660	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TP50_RS10670	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TP50_RS10690	COG1946	Acyl-CoA thioesterase
TP50_RS10705	COG0824	Thioesterase
TP50_RS10710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TP50_RS10715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TP50_RS10720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TP50_RS10725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TP50_RS10730	COG0268	Binds directly to 16S ribosomal RNA
TP50_RS10740	COG0196	riboflavin kinase activity
TP50_RS10745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TP50_RS10750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TP50_RS10755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TP50_RS10795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TP50_RS10800	COG1845	cytochrome c oxidase, subunit III
TP50_RS10805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TP50_RS10820	COG3152	Membrane
TP50_RS10830	COG3039	Transposase
TP50_RS10835	COG2207	Transcriptional regulator
TP50_RS10850	COG1366	Belongs to the anti-sigma-factor antagonist family
TP50_RS10855	COG1366	Belongs to the anti-sigma-factor antagonist family
TP50_RS10860	COG2172	sigma factor antagonist activity
TP50_RS10890	COG4771	TonB-dependent receptor
TP50_RS10900	COG5507	3-demethylubiquinone-9 3-methyltransferase
TP50_RS10905	COG2205	protein histidine kinase activity
TP50_RS10915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP50_RS10920	COG2205	protein histidine kinase activity
TP50_RS10920	COG3437	response regulator, receiver
TP50_RS10920	COG3850	Histidine kinase
TP50_RS10920	COG4999	Histidine kinase
TP50_RS10925	COG4191	Histidine kinase
TP50_RS10925	COG0784	Response regulator, receiver
TP50_RS10950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP50_RS10955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TP50_RS10975	COG0228	four-way junction DNA binding
TP50_RS10980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TP50_RS10985	COG0336	Belongs to the RNA methyltransferase TrmD family
TP50_RS10990	COG0335	large ribosomal subunit rRNA binding
TP50_RS10995	COG0534	Mate efflux family protein
TP50_RS11020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TP50_RS11030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TP50_RS11060	COG3250	beta-galactosidase activity
TP50_RS11065	COG3867	Arabinogalactan endo-beta-1,4-galactanase
TP50_RS11085	COG1960	acyl-CoA dehydrogenase activity
TP50_RS11090	COG1024	Enoyl-CoA hydratase
TP50_RS11115	COG3039	Transposase
TP50_RS11125	COG1477	protein flavinylation
TP50_RS11150	COG3128	pkhd-type hydroxylase
TP50_RS11155	COG4774	siderophore transport
TP50_RS11160	COG2146	nitrite reductase [NAD(P)H] activity
TP50_RS11170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TP50_RS11175	COG0719	Fe-S assembly protein
TP50_RS11180	COG0396	ATPase activity
TP50_RS11185	COG0719	Fe-S assembly protein
TP50_RS11190	COG1959	2 iron, 2 sulfur cluster binding
TP50_RS11205	COG3039	Transposase
TP50_RS11210	COG0693	protein deglycase activity
TP50_RS11230	COG0739	heme binding
TP50_RS11245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TP50_RS11270	COG0519	Catalyzes the synthesis of GMP from XMP
TP50_RS11280	COG1678	Uncharacterized ACR, COG1678
TP50_RS11285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TP50_RS11290	COG0540	Belongs to the ATCase OTCase family
TP50_RS11295	COG1764	response to oxidative stress
TP50_RS11305	COG0384	phenazine biosynthesis protein PhzF
TP50_RS11310	COG0384	phenazine biosynthesis protein PhzF
TP50_RS11315	COG0527	aspartate kinase activity
TP50_RS11330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TP50_RS11345	COG0142	geranyltranstransferase activity
TP50_RS11350	COG0629	single-stranded DNA binding
TP50_RS11355	COG5001	Diguanylate cyclase
TP50_RS11355	COG3706	GGDEF domain
TP50_RS11355	COG4251	negative regulation of phosphorylation
TP50_RS11355	COG2203	Gaf domain
TP50_RS11360	COG0604	alcohol dehydrogenase
TP50_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS11360	COG3321	synthase
TP50_RS11365	COG2080	2 iron, 2 sulfur cluster binding
TP50_RS11370	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP50_RS11375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP50_RS11380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TP50_RS11425	COG3039	Transposase
TP50_RS11430	COG2879	small protein
TP50_RS11435	COG1966	Carbon starvation protein
TP50_RS11440	COG1741	Belongs to the pirin family
TP50_RS11455	COG1741	Belongs to the pirin family
TP50_RS11465	COG3039	Transposase
TP50_RS11470	COG1515	deoxyribonuclease V activity
TP50_RS11475	COG0588	phosphoglycerate mutase activity
TP50_RS11485	COG3590	peptidase
TP50_RS11495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_RS11500	COG2201	protein-glutamate methylesterase activity
TP50_RS11505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP50_RS11510	COG2202	Pas domain
TP50_RS11510	COG2200	EAL domain
TP50_RS11510	COG2199	diguanylate cyclase activity
TP50_RS11515	COG0835	chemotaxis
TP50_RS11520	COG0840	transmembrane signaling receptor activity
TP50_RS11525	COG2198	Histidine kinase
TP50_RS11525	COG0643	Histidine kinase
TP50_RS11580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TP50_RS11590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TP50_RS11595	COG3039	Transposase
TP50_RS11600	COG0745	RESPONSE REGULATOR receiver
TP50_RS11605	COG2205	protein histidine kinase activity
TP50_RS11615	COG4452	Inner membrane protein CreD
TP50_RS11640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP50_RS11645	COG0735	belongs to the Fur family
TP50_RS11660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_RS11670	COG1309	transcriptional regulator
TP50_RS11680	COG2207	Transcriptional regulator
TP50_RS11690	COG0583	DNA-binding transcription factor activity
TP50_RS11695	COG2814	Major facilitator Superfamily
TP50_RS11700	COG0667	Aldo Keto reductase
TP50_RS11755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TP50_RS11770	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_RS11780	COG0497	DNA recombination
TP50_RS11785	COG1420	regulation of RNA biosynthetic process
TP50_RS11790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TP50_RS11795	COG0443	Heat shock 70 kDa protein
TP50_RS11800	COG0484	heat shock protein binding
TP50_RS11810	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TP50_RS11840	COG0583	DNA-binding transcription factor activity
TP50_RS11845	COG1132	(ABC) transporter
TP50_RS11870	COG0567	Dehydrogenase, E1 component
TP50_RS11880	COG2850	peptidyl-arginine hydroxylation
TP50_RS11905	COG1253	flavin adenine dinucleotide binding
TP50_RS11940	COG1131	(ABC) transporter
TP50_RS11945	COG1725	Transcriptional regulator
TP50_RS11955	COG0386	Belongs to the glutathione peroxidase family
TP50_RS11970	COG2900	Belongs to the SlyX family
TP50_RS12005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP50_RS12015	COG0646	methionine synthase
TP50_RS12015	COG1410	methionine synthase
TP50_RS12020	COG0646	methionine synthase
TP50_RS12020	COG1410	methionine synthase
TP50_RS12025	COG2226	methyltransferase
TP50_RS12030	COG1960	acyl-CoA dehydrogenase activity
TP50_RS12040	COG1960	acyl-CoA dehydrogenase activity
TP50_RS12060	COG0557	exoribonuclease II activity
TP50_RS12070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP50_RS12080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP50_RS12090	COG0704	Plays a role in the regulation of phosphate uptake
TP50_RS12095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TP50_RS12100	COG0581	inorganic phosphate transmembrane transporter activity
TP50_RS12105	COG0573	inorganic phosphate transmembrane transporter activity
TP50_RS12110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TP50_RS12135	COG0659	secondary active sulfate transmembrane transporter activity
TP50_RS12140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TP50_RS12150	COG1024	Enoyl-CoA hydratase
TP50_RS12160	COG0494	nUDIX hydrolase
TP50_RS12195	COG0488	(ABC) transporter
TP50_RS12205	COG0116	Belongs to the methyltransferase superfamily
TP50_RS12205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP50_RS12210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TP50_RS12230	COG2925	Exonuclease
TP50_RS12235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_RS12240	COG3844	kynureninase activity
TP50_RS12250	COG0662	Cupin 2, conserved barrel domain protein
TP50_RS12255	COG0288	reversible hydration of carbon dioxide
TP50_RS12340	COG0017	Asparaginyl-tRNA synthetase
TP50_RS12350	COG0316	Belongs to the HesB IscA family
TP50_RS12355	COG0360	Binds together with S18 to 16S ribosomal RNA
TP50_RS12360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TP50_RS12365	COG0359	binds to the 23S rRNA
TP50_RS12380	COG3115	cell septum assembly
TP50_RS12390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP50_RS12395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TP50_RS12400	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TP50_RS12415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TP50_RS12425	COG4993	Dehydrogenase
TP50_RS12435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TP50_RS12445	COG2986	histidine ammonia-lyase
TP50_RS12450	COG1228	amidohydrolase
TP50_RS12490	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TP50_RS12500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TP50_RS12505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TP50_RS12510	COG1605	Chorismate mutase
TP50_RS12510	COG0077	Prephenate dehydratase
TP50_RS12515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TP50_RS12530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TP50_RS12535	COG3039	Transposase
TP50_RS12540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TP50_RS12550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TP50_RS12555	COG0583	DNA-binding transcription factor activity
TP50_RS12600	COG1335	isochorismatase
TP50_RS12615	COG2814	Major facilitator Superfamily
TP50_RS12630	COG1648	precorrin-2 dehydrogenase activity
TP50_RS12630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TP50_RS12635	COG0243	molybdopterin cofactor binding
TP50_RS12650	COG3685	Protein conserved in bacteria
TP50_RS12670	COG5001	Diguanylate cyclase
TP50_RS12675	COG2963	transposase activity
TP50_RS12685	COG2801	Transposase and inactivated derivatives
TP50_RS12700	COG4566	intracellular signal transduction
TP50_RS12740	COG3275	phosphorelay sensor kinase activity
TP50_RS12745	COG3279	Response regulator of the LytR AlgR family
TP50_RS12785	COG1238	metal cluster binding
TP50_RS12805	COG3920	Histidine kinase
TP50_RS12830	COG3220	belongs to the UPF0276 family
TP50_RS12845	COG3039	Transposase
TP50_RS12850	COG2963	transposase activity
TP50_RS12865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TP50_RS12890	COG4644	lycopene metabolic process
TP50_RS12895	COG2951	lytic endotransglycosylase activity
TP50_RS12905	COG3039	Transposase
TP50_RS13025	COG3039	Transposase
TP50_RS13090	COG2801	Transposase and inactivated derivatives
TP50_RS13095	COG0582	viral genome integration into host DNA
TP50_RS13100	COG0519	Catalyzes the synthesis of GMP from XMP
TP50_RS13100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP50_RS13110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TP50_RS13130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP50_RS13130	COG0475	glutathione-regulated potassium exporter activity
TP50_RS13135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TP50_RS13145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP50_RS13150	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TP50_RS13160	COG0776	regulation of translation
TP50_RS13165	COG0539	negative regulation of cytoplasmic translation
TP50_RS13170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TP50_RS13185	COG2957	Belongs to the agmatine deiminase family
TP50_RS13190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP50_RS13220	COG0395	ABC-type sugar transport system, permease component
TP50_RS13225	COG1175	transmembrane transport
TP50_RS13255	COG2350	Protein conserved in bacteria
TP50_RS13260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TP50_RS13265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TP50_RS13270	COG1187	pseudouridine synthase activity
TP50_RS13275	COG2801	Transposase and inactivated derivatives
TP50_RS13290	COG2801	Transposase and inactivated derivatives
TP50_RS13325	COG0405	Gamma-glutamyltransferase
TP50_RS13335	COG3039	Transposase
TP50_RS13340	COG4206	TonB-dependent receptor
TP50_RS13365	COG1012	belongs to the aldehyde dehydrogenase family
TP50_RS13380	COG0167	dihydroorotate dehydrogenase activity
TP50_RS13385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TP50_RS13390	COG0697	spore germination
TP50_RS13400	COG1794	racemase activity, acting on amino acids and derivatives
TP50_RS13415	COG0671	phosphoesterase, PA-phosphatase related
TP50_RS13420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TP50_RS13430	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TP50_RS13435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP50_RS13445	COG3706	GGDEF domain
TP50_RS13445	COG5001	Diguanylate cyclase
TP50_RS13445	COG4251	negative regulation of phosphorylation
TP50_RS13445	COG2203	Gaf domain
TP50_RS13460	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_RS13485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TP50_RS13490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TP50_RS13495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TP50_RS13515	COG1469	GTP cyclohydrolase I activity
TP50_RS13520	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP50_RS13525	COG3039	Transposase
TP50_RS13550	COG0477	Major facilitator Superfamily
TP50_RS13555	COG2115	Belongs to the xylose isomerase family
TP50_RS13560	COG1070	Carbohydrate kinase
TP50_RS13570	COG1501	Belongs to the glycosyl hydrolase 31 family
TP50_RS13610	COG0800	Aldolase
TP50_RS13615	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_RS13625	COG3734	2-keto-3-deoxy-galactonokinase
TP50_RS13630	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TP50_RS13640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP50_RS13655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TP50_RS13660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TP50_RS13675	COG0351	phosphomethylpyrimidine kinase
TP50_RS13725	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TP50_RS13730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TP50_RS13735	COG2137	regulation of response to DNA damage stimulus
TP50_RS13745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TP50_RS13750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP50_RS13760	COG1546	Belongs to the CinA family
TP50_RS13765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TP50_RS13775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TP50_RS13780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TP50_RS13790	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TP50_RS13795	COG1534	Rna-binding protein
TP50_RS13810	COG1238	metal cluster binding
TP50_RS13815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP50_RS13820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TP50_RS13825	COG2840	Smr protein MutS2
TP50_RS13830	COG0585	pseudouridine synthase activity
TP50_RS13835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TP50_RS13840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TP50_RS13845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TP50_RS13850	COG0148	phosphopyruvate hydratase activity
TP50_RS13865	COG0504	CTP synthase activity
TP50_RS13870	COG3039	Transposase
TP50_RS13905	COG0306	phosphate transporter
TP50_RS13920	COG1253	flavin adenine dinucleotide binding
TP50_RS13935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP50_RS13940	COG0477	Major facilitator Superfamily
TP50_RS13950	COG1136	(ABC) transporter
TP50_RS13975	COG2264	protein methyltransferase activity
TP50_RS14005	COG2244	polysaccharide biosynthetic process
TP50_RS14060	COG1595	DNA-templated transcription, initiation
TP50_RS14075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP50_RS14085	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP50_RS14095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP50_RS14110	COG4191	Histidine kinase
TP50_RS14110	COG0784	Response regulator, receiver
TP50_RS14115	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TP50_RS14165	COG2197	response regulator
TP50_RS14185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP50_RS14190	COG3002	Belongs to the UPF0753 family
TP50_RS14240	COG3479	Phenolic acid decarboxylase
TP50_RS14250	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS14285	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TP50_RS14285	COG0316	Belongs to the HesB IscA family
TP50_RS14290	COG2154	pterin-4-alpha-carbinolamine dehydratase
TP50_RS14300	COG0428	transporter
TP50_RS14305	COG3064	Membrane
TP50_RS14315	COG1530	ribonuclease E activity
TP50_RS14330	COG1054	Belongs to the UPF0176 family
TP50_RS14350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TP50_RS14375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP50_RS14380	COG0322	excinuclease ABC activity
TP50_RS14390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TP50_RS14395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TP50_RS14400	COG1663	tetraacyldisaccharide 4'-kinase activity
TP50_RS14405	COG1132	(ABC) transporter
TP50_RS14410	COG0848	biopolymer transport protein
TP50_RS14415	COG0811	peptide transport
TP50_RS14430	COG1136	(ABC) transporter
TP50_RS14435	COG4591	ABC-type transport system involved in lipoprotein release permease component
TP50_RS14445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TP50_RS14450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TP50_RS14465	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TP50_RS14480	COG0354	folic acid binding
TP50_RS14490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP50_RS14495	COG0837	glucose binding
TP50_RS14500	COG0363	glucosamine-6-phosphate deaminase activity
TP50_RS14505	COG0129	dihydroxy-acid dehydratase activity
TP50_RS14510	COG0800	Aldolase
TP50_RS14565	COG2205	protein histidine kinase activity
TP50_RS14565	COG0784	Response regulator, receiver
TP50_RS14570	COG2183	response to ionizing radiation
TP50_RS14580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_RS14580	COG0723	plastoquinol--plastocyanin reductase activity
TP50_RS14595	COG3243	poly(R)-hydroxyalkanoic acid synthase
TP50_RS14605	COG1183	phosphatidylcholine synthase activity
TP50_RS14610	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS14635	COG0668	transmembrane transport
TP50_RS14655	COG1914	H( )-stimulated, divalent metal cation uptake system
TP50_RS14670	COG2072	flavoprotein involved in K transport
TP50_RS14690	COG0746	molybdenum cofactor guanylyltransferase activity
TP50_RS14695	COG0303	'Molybdopterin
TP50_RS14705	COG0708	Exodeoxyribonuclease III
TP50_RS14760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TP50_RS14765	COG0303	'Molybdopterin
TP50_RS14770	COG1160	GTP binding
TP50_RS14775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_RS14785	COG1426	Protein conserved in bacteria
TP50_RS14795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TP50_RS14810	COG1024	Enoyl-CoA hydratase
TP50_RS14810	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP50_RS14815	COG0183	Belongs to the thiolase family
TP50_RS14825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TP50_RS14830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TP50_RS14840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TP50_RS14850	COG1674	ftsk spoiiie
TP50_RS14855	COG0492	ferredoxin-NADP+ reductase activity
TP50_RS14865	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TP50_RS14875	COG0542	response to heat
TP50_RS14890	COG0482	sulfurtransferase activity
TP50_RS14895	COG2915	High frequency lysogenization protein hflD homolog
TP50_RS14930	COG5002	protein histidine kinase activity
TP50_RS14950	COG0784	Response regulator, receiver
TP50_RS14950	COG0835	chemotaxis
TP50_RS14960	COG1558	bacterial-type flagellum-dependent cell motility
TP50_RS14965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TP50_RS14975	COG4787	bacterial-type flagellum-dependent cell motility
TP50_RS14990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TP50_RS14995	COG1706	bacterial-type flagellum-dependent cell motility
TP50_RS15000	COG1705	Flagellar rod assembly protein muramidase FlgJ
TP50_RS15000	COG3951	Flagellar rod assembly protein muramidase FlgJ
TP50_RS15010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TP50_RS15020	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TP50_RS15050	COG2201	protein-glutamate methylesterase activity
TP50_RS15070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_RS15075	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS15090	COG4638	Rieske (2fe-2S)
TP50_RS15120	COG1677	Flagellar hook-basal body complex protein FliE
TP50_RS15170	COG3190	flagellar
TP50_RS15190	COG1684	flagellar biosynthetic protein fliR
TP50_RS15255	COG2198	Histidine kinase
TP50_RS15255	COG0784	Response regulator, receiver
TP50_RS15255	COG0643	Histidine kinase
TP50_RS15270	COG3039	Transposase
TP50_RS15285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TP50_RS15290	COG1360	Flagellar Motor Protein
TP50_RS15300	COG0835	chemotaxis
TP50_RS15310	COG0745	RESPONSE REGULATOR receiver
TP50_RS15320	COG0840	transmembrane signaling receptor activity
TP50_RS15340	COG0840	transmembrane signaling receptor activity
TP50_RS15355	COG0840	transmembrane signaling receptor activity
TP50_RS15360	COG0840	transmembrane signaling receptor activity
TP50_RS15365	COG3039	Transposase
TP50_RS15370	COG0840	transmembrane signaling receptor activity
TP50_RS15380	COG0840	transmembrane signaling receptor activity
TP50_RS15390	COG0840	transmembrane signaling receptor activity
TP50_RS15395	COG0840	transmembrane signaling receptor activity
TP50_RS15400	COG0840	transmembrane signaling receptor activity
TP50_RS15405	COG0840	transmembrane signaling receptor activity
TP50_RS15415	COG0840	transmembrane signaling receptor activity
TP50_RS15430	COG0835	chemotaxis
TP50_RS15440	COG0840	transmembrane signaling receptor activity
TP50_RS15450	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TP50_RS15455	COG2201	protein-glutamate methylesterase activity
TP50_RS15470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP50_RS15500	COG0318	PFAM AMP-dependent synthetase and ligase
TP50_RS15505	COG1024	Enoyl-CoA hydratase
TP50_RS15510	COG0784	Response regulator, receiver
TP50_RS15510	COG2205	protein histidine kinase activity
TP50_RS15510	COG2198	Histidine kinase
TP50_RS15515	COG0784	Response regulator, receiver
TP50_RS15515	COG2198	Histidine kinase
TP50_RS15515	COG2205	protein histidine kinase activity
TP50_RS15525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TP50_RS15530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TP50_RS15545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TP50_RS15555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP50_RS15560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TP50_RS15570	COG0505	Belongs to the CarA family
TP50_RS15575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TP50_RS15580	COG2258	MOSC domain
TP50_RS15585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP50_RS15630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP50_RS15650	COG0277	FAD linked oxidase domain protein
TP50_RS15655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TP50_RS15665	COG0531	amino acid
TP50_RS15670	COG0531	amino acid
TP50_RS15675	COG0235	Class ii aldolase
TP50_RS15680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TP50_RS15685	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TP50_RS15705	COG0140	phosphoribosyl-ATP diphosphatase activity
TP50_RS15705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TP50_RS15710	COG0107	imidazoleglycerol-phosphate synthase activity
TP50_RS15715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TP50_RS15720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TP50_RS15725	COG0131	Imidazoleglycerol-phosphate dehydratase
TP50_RS15725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TP50_RS15730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP50_RS15735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TP50_RS15740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TP50_RS15750	COG0124	histidyl-tRNA synthetase
TP50_RS15755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP50_RS15765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TP50_RS15800	COG3039	Transposase
TP50_RS15850	COG2801	Transposase and inactivated derivatives
TP50_RS15895	COG0784	Response regulator, receiver
TP50_RS15895	COG2205	protein histidine kinase activity
TP50_RS15905	COG3039	Transposase
TP50_RS15930	COG0436	Aminotransferase
TP50_RS15935	COG4133	protoheme IX ABC transporter activity
TP50_RS15955	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP50_RS15960	COG1138	Cytochrome C-type biogenesis protein
TP50_RS15980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP50_RS15985	COG1278	Cold shock
TP50_RS15990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TP50_RS15995	COG4988	ABC transporter
TP50_RS16005	COG1294	oxidase, subunit
TP50_RS16040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TP50_RS16045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TP50_RS16055	COG0165	Argininosuccinate lyase
TP50_RS16060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TP50_RS16070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TP50_RS16075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TP50_RS16085	COG0137	argininosuccinate synthase activity
TP50_RS16090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TP50_RS16100	COG0215	cysteine-tRNA ligase activity
TP50_RS16105	COG2166	iron-sulfur cluster assembly
TP50_RS16120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TP50_RS16125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TP50_RS16145	COG4302	ethanolamine ammonia-lyase activity
TP50_RS16175	COG3039	Transposase
TP50_RS16220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TP50_RS16225	COG0402	S-adenosylhomocysteine deaminase activity
TP50_RS16235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP50_RS16240	COG1509	lysine 2,3-aminomutase activity
TP50_RS16245	COG3300	MHYT domain
TP50_RS16245	COG5001	Diguanylate cyclase
TP50_RS16260	COG0483	inositol monophosphate 1-phosphatase activity
TP50_RS16265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TP50_RS16285	COG0488	(ABC) transporter
TP50_RS16290	COG0513	Belongs to the DEAD box helicase family
TP50_RS16295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TP50_RS16300	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TP50_RS16310	COG0625	glutathione transferase activity
TP50_RS16320	COG4681	YaeQ
TP50_RS16325	COG2081	HI0933 family
TP50_RS16335	COG0501	Belongs to the peptidase M48B family
TP50_RS16340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP50_RS16345	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS16370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TP50_RS16375	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP50_RS16380	COG0802	atpase or kinase
TP50_RS16385	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TP50_RS16385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP50_RS16390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP50_RS16395	COG1570	exodeoxyribonuclease VII activity
TP50_RS16405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP50_RS16455	COG0835	chemotaxis
TP50_RS16460	COG0840	transmembrane signaling receptor activity
TP50_RS16465	COG2094	Belongs to the DNA glycosylase MPG family
TP50_RS16470	COG1201	RNA secondary structure unwinding
TP50_RS16490	COG2969	positive regulation of protein catabolic process
TP50_RS16495	COG0625	glutathione transferase activity
TP50_RS16505	COG2857	Cytochrome c1
TP50_RS16510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TP50_RS16515	COG0723	plastoquinol--plastocyanin reductase activity
TP50_RS16525	COG0741	lytic transglycosylase activity
TP50_RS16540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP50_RS16545	COG1702	phosphate starvation-inducible protein PhoH
TP50_RS16555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TP50_RS16565	COG4535	Mg2 and Co2 transporter CorC
TP50_RS16580	COG1012	belongs to the aldehyde dehydrogenase family
TP50_RS16585	COG1177	transmembrane transport
TP50_RS16590	COG1176	ABC-type spermidine putrescine transport system, permease component I
TP50_RS16600	COG3842	ATPase activity
TP50_RS16620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TP50_RS16635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TP50_RS16640	COG0174	glutamine synthetase
TP50_RS16645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_RS16655	COG2703	oxygen carrier activity
TP50_RS16660	COG0477	Major facilitator Superfamily
TP50_RS16675	COG0243	molybdopterin cofactor binding
TP50_RS16680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TP50_RS16685	COG2223	nitrite transmembrane transporter activity
TP50_RS16700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TP50_RS16710	COG2733	membrane
TP50_RS16715	COG0784	Response regulator, receiver
TP50_RS16715	COG2205	protein histidine kinase activity
TP50_RS16715	COG5002	protein histidine kinase activity
TP50_RS16735	COG0477	Major facilitator Superfamily
TP50_RS16770	COG2902	Dehydrogenase
TP50_RS16780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_RS16785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_RS16790	COG1609	Transcriptional regulator
TP50_RS16795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP50_RS16795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP50_RS16800	COG1105	Belongs to the carbohydrate kinase PfkB family
TP50_RS16805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP50_RS16805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP50_RS16825	COG2963	transposase activity
TP50_RS16830	COG0823	Involved in the tonB-independent uptake of proteins
TP50_RS16830	COG1506	peptidase
TP50_RS16845	COG1297	OPT oligopeptide transporter protein
TP50_RS16860	COG0587	DNA-directed DNA polymerase activity
TP50_RS16875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP50_RS16910	COG2080	2 iron, 2 sulfur cluster binding
TP50_RS16915	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP50_RS16920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP50_RS16955	COG0492	ferredoxin-NADP+ reductase activity
TP50_RS16970	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS16975	COG3537	Alpha-1,2-mannosidase
TP50_RS16985	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS16990	COG3387	PFAM Glycoside hydrolase 15-related
TP50_RS17000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP50_RS17045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TP50_RS17070	COG1309	transcriptional regulator
TP50_RS17075	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS17085	COG0308	aminopeptidase N
TP50_RS17090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TP50_RS17095	COG0330	HflC and HflK could
TP50_RS17100	COG0330	HflC and HflK could
TP50_RS17120	COG0678	peroxiredoxin activity
TP50_RS17130	COG4953	penicillin-binding protein 1C
TP50_RS17150	COG2373	Large extracellular alpha-helical protein
TP50_RS17170	COG2828	Protein conserved in bacteria
TP50_RS17200	COG3829	transcription factor binding
TP50_RS17225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TP50_RS17230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TP50_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS17250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TP50_RS17260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_RS17270	COG1399	metal-binding, possibly nucleic acid-binding protein
TP50_RS17275	COG0424	maF-like protein
TP50_RS17300	COG0714	Associated with various cellular activities
TP50_RS17320	COG0537	adenosine 5'-monophosphoramidase activity
TP50_RS17325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TP50_RS17330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TP50_RS17350	COG0314	molybdopterin synthase activity
TP50_RS17355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TP50_RS17360	COG0315	cyclic pyranopterin monophosphate synthase activity
TP50_RS17370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TP50_RS17375	COG1234	tRNA 3'-trailer cleavage
TP50_RS17380	COG3642	lipopolysaccharide core region biosynthetic process
TP50_RS17385	COG0859	PFAM glycosyl transferase family 9
TP50_RS17400	COG0631	protein serine/threonine phosphatase activity
TP50_RS17405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP50_RS17410	COG0328	RNA-DNA hybrid ribonuclease activity
TP50_RS17420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_RS17430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP50_RS17460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TP50_RS17470	COG0544	peptidyl-prolyl cis-trans isomerase activity
TP50_RS17480	COG3852	Histidine kinase
TP50_RS17505	COG3039	Transposase
TP50_RS17520	COG4695	Portal protein
TP50_RS17670	COG0473	3-isopropylmalate dehydrogenase activity
TP50_RS17685	COG4783	chaperone-mediated protein folding
TP50_RS17700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TP50_RS17710	COG0438	transferase activity, transferring glycosyl groups
TP50_RS17715	COG0671	phosphoesterase, PA-phosphatase related
TP50_RS17720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_RS17730	COG3291	Pkd domain containing protein
TP50_RS17740	COG2833	Protein of unknown function (DUF455)
TP50_RS17760	COG0285	dihydrofolate synthase activity
TP50_RS17765	COG0406	alpha-ribazole phosphatase activity
TP50_RS17795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TP50_RS17800	COG4208	sulfate ABC transporter
TP50_RS17805	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TP50_RS17810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TP50_RS17815	COG0156	8-amino-7-oxononanoate synthase activity
TP50_RS17845	COG0604	alcohol dehydrogenase
TP50_RS17850	COG0446	pyridine nucleotide-disulphide oxidoreductase
TP50_RS17850	COG1902	pentaerythritol trinitrate reductase activity
TP50_RS17875	COG0625	glutathione transferase activity
TP50_RS17880	COG0039	L-malate dehydrogenase activity
TP50_RS17885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP50_RS17890	COG1217	gtp-binding protein TYPA
TP50_RS17900	COG0154	amidase activity
TP50_RS17935	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TP50_RS17945	COG0203	ribosomal protein L17
TP50_RS17970	COG0201	protein transport
TP50_RS17975	COG0200	Binds to the 23S rRNA
TP50_RS17980	COG1841	ribosomal large subunit assembly
TP50_RS17990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TP50_RS17995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TP50_RS18000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TP50_RS18010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TP50_RS18015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TP50_RS18025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TP50_RS18030	COG0255	Belongs to the universal ribosomal protein uL29 family
TP50_RS18035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TP50_RS18040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TP50_RS18050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TP50_RS18055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TP50_RS18060	COG0089	rRNA binding
TP50_RS18065	COG0088	Forms part of the polypeptide exit tunnel
TP50_RS18070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TP50_RS18075	COG0051	transcription antitermination factor activity, RNA binding
TP50_RS18080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP50_RS18085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TP50_RS18090	COG0049	tRNA binding
TP50_RS18095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TP50_RS18100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TP50_RS18105	COG0085	RNA polymerase activity
TP50_RS18110	COG0222	ribosome binding
TP50_RS18115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TP50_RS18120	COG0081	regulation of translation
TP50_RS18125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TP50_RS18130	COG0250	Participates in transcription elongation, termination and antitermination
TP50_RS18145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP50_RS18165	COG0012	GTP binding
TP50_RS18170	COG0193	aminoacyl-tRNA hydrolase activity
TP50_RS18175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TP50_RS18180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TP50_RS18190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TP50_RS18195	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TP50_RS18205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TP50_RS18210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TP50_RS18220	COG0521	Mo-molybdopterin cofactor biosynthetic process
TP50_RS18235	COG1254	Belongs to the acylphosphatase family
TP50_RS18240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP50_RS18245	COG1295	ribonuclease BN
TP50_RS18275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TP50_RS18280	COG1404	Belongs to the peptidase S8 family
TP50_RS18290	COG1404	Belongs to the peptidase S8 family
TP50_RS18295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TP50_RS18340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TP50_RS18345	COG3039	Transposase
TP50_RS18375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP50_RS18375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP50_RS18395	COG2890	protein-(glutamine-N5) methyltransferase activity
TP50_RS18405	COG3634	alkyl hydroperoxide reductase activity
TP50_RS18410	COG0583	DNA-binding transcription factor activity
TP50_RS18420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP50_RS18425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TP50_RS18435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TP50_RS18445	COG2197	response regulator
TP50_RS18470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP50_RS18480	COG0697	spore germination
TP50_RS18505	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TP50_RS18535	COG1024	Enoyl-CoA hydratase
TP50_RS18545	COG3039	Transposase
TP50_RS18570	COG2155	Conserved Protein
TP50_RS18590	COG3039	Transposase
TP50_RS18625	COG1132	(ABC) transporter
TP50_RS18650	COG1538	Outer membrane efflux protein
TP50_RS18655	COG0745	RESPONSE REGULATOR receiver
TP50_RS18660	COG5000	phosphorelay sensor kinase activity
TP50_RS18660	COG5002	protein histidine kinase activity
TP50_RS18665	COG0475	glutathione-regulated potassium exporter activity
TP50_RS18675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP50_RS18710	COG1187	pseudouridine synthase activity
TP50_RS18715	COG5002	protein histidine kinase activity
TP50_RS18715	COG5001	Diguanylate cyclase
TP50_RS18760	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TP50_RS18835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TP50_RS18845	COG1862	Preprotein translocase
TP50_RS18850	COG0343	queuine tRNA-ribosyltransferase activity
TP50_RS18855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TP50_RS18890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TP50_RS18895	COG3291	Pkd domain containing protein
TP50_RS18900	COG0405	Gamma-glutamyltransferase
TP50_RS18905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TP50_RS18920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TP50_RS18925	COG0742	ribosomal rna small subunit methyltransferase
TP50_RS18930	COG0326	Molecular chaperone. Has ATPase activity
TP50_RS18945	COG3039	Transposase
TP50_RS19035	COG0531	amino acid
TP50_RS19050	COG0006	proline dipeptidase activity
TP50_RS19060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP50_RS19075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_RS19080	COG3938	Belongs to the proline racemase family
TP50_RS19090	COG0552	protein localization to endoplasmic reticulum
TP50_RS19100	COG1194	a g-specific adenine glycosylase
TP50_RS19105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TP50_RS19110	COG0784	Response regulator, receiver
TP50_RS19110	COG4191	Histidine kinase
TP50_RS19125	COG0322	excinuclease ABC activity
TP50_RS19140	COG3040	lipid binding
TP50_RS19150	COG1960	acyl-CoA dehydrogenase activity
TP50_RS19160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TP50_RS19180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP50_RS19185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_RS19190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_RS19215	COG0438	transferase activity, transferring glycosyl groups
TP50_RS19225	COG0438	transferase activity, transferring glycosyl groups
TP50_RS19230	COG0438	transferase activity, transferring glycosyl groups
TP50_RS19280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP50_RS19280	COG0072	phenylalanine-tRNA ligase activity
TP50_RS19285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TP50_RS19300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TP50_RS19305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TP50_RS19320	COG3039	Transposase
TP50_RS19325	COG3039	Transposase
TP50_RS19330	COG1874	Beta-galactosidase
TP50_RS19330	COG0366	Alpha amylase catalytic
TP50_RS19335	COG2190	(PTS) system
TP50_RS19335	COG2211	Major facilitator Superfamily
TP50_RS19345	COG1082	Xylose isomerase domain protein TIM barrel
TP50_RS19390	COG3505	Type IV secretory pathway VirD4
TP50_RS19405	COG0556	nucleotide-excision repair
TP50_RS19460	COG1611	Belongs to the LOG family
TP50_RS19475	COG2095	MarC family integral membrane protein
TP50_RS19485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP50_RS19520	COG1185	polyribonucleotide nucleotidyltransferase activity
TP50_RS19525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TP50_RS19530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TP50_RS19535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TP50_RS19540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TP50_RS19545	COG0195	Participates in both transcription termination and antitermination
TP50_RS19550	COG0779	Required for maturation of 30S ribosomal subunits
TP50_RS19560	COG1007	ATP synthesis coupled electron transport
TP50_RS19585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_RS19590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TP50_RS19600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TP50_RS19605	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TP50_RS19610	COG0649	NAD binding
TP50_RS19615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_RS19620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_RS19625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_RS19640	COG0149	triose-phosphate isomerase activity
TP50_RS19675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP50_RS19680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TP50_RS19685	COG0159	tryptophan synthase activity
TP50_RS19695	COG0133	tryptophan synthase activity
TP50_RS19705	COG3039	Transposase
TP50_RS19710	COG0135	phosphoribosylanthranilate isomerase activity
TP50_RS19715	COG0101	tRNA pseudouridine synthase activity
TP50_RS19730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TP50_RS19735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TP50_RS19740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TP50_RS19745	COG2890	protein-(glutamine-N5) methyltransferase activity
TP50_RS19755	COG0688	phosphatidylethanolamine metabolic process
TP50_RS19770	COG0433	COG0433 Predicted ATPase
TP50_RS19775	COG0494	nUDIX hydrolase
TP50_RS19800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP50_RS19805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP50_RS19830	COG0717	Belongs to the dCTP deaminase family
TP50_RS19840	COG0489	protein tyrosine kinase activity
TP50_RS19845	COG4206	TonB-dependent receptor
TP50_RS19860	COG3590	peptidase
TP50_RS19865	COG3590	peptidase
TP50_RS19890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP50_RS19895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_RS19900	COG2311	Membrane
TP50_RS19905	COG1047	Peptidyl-prolyl cis-trans
TP50_RS19910	COG0791	NLP P60 protein
TP50_RS19915	COG0791	NLP P60 protein
TP50_RS19925	COG4106	trans-aconitate 2-methyltransferase activity
TP50_RS19930	COG1301	dicarboxylic acid transport
TP50_RS19935	COG1785	Belongs to the alkaline phosphatase family
TP50_RS19945	COG0037	tRNA processing
TP50_RS19950	COG1722	exodeoxyribonuclease VII activity
TP50_RS19955	COG0142	geranyltranstransferase activity
TP50_RS19970	COG0312	modulator of DNA gyrase
TP50_RS19975	COG3028	Belongs to the UPF0307 family
TP50_RS19980	COG0312	modulator of DNA gyrase
TP50_RS19990	COG3164	Protein of unknown function
TP50_RS20000	COG0424	maF-like protein
TP50_RS20005	COG2968	Membrane
TP50_RS20020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TP50_RS20035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TP50_RS20050	COG0495	leucyl-tRNA aminoacylation
TP50_RS20060	COG3118	belongs to the thioredoxin family
TP50_RS20090	COG3039	Transposase
TP50_RS20105	COG2951	lytic endotransglycosylase activity
TP50_RS20110	COG4644	lycopene metabolic process
TP50_RS20155	COG3039	Transposase
TP50_RS20170	COG0583	DNA-binding transcription factor activity
TP50_RS20175	COG3384	dioxygenase
TP50_RS20205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_RS20210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_RS20250	COG1196	nuclear chromosome segregation
TP50_RS20295	COG1754	DNA topoisomerase type I activity
TP50_RS20295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TP50_RS20300	COG0009	L-threonylcarbamoyladenylate synthase
TP50_RS20315	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS20325	COG0616	signal peptide processing
TP50_RS20330	COG0534	Mate efflux family protein
TP50_RS20350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TP50_RS20355	COG0625	glutathione transferase activity
TP50_RS20370	COG1252	NADH dehydrogenase
TP50_RS20375	COG2860	membrane
TP50_RS20380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP50_RS20385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TP50_RS20390	COG3437	response regulator, receiver
TP50_RS20395	COG2177	Part of the ABC transporter FtsEX involved in
TP50_RS20400	COG2884	Cell division ATP-binding protein ftsE
TP50_RS20405	COG0513	Belongs to the DEAD box helicase family
TP50_RS20410	COG3118	belongs to the thioredoxin family
TP50_RS20415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TP50_RS20425	COG0583	DNA-binding transcription factor activity
TP50_RS20445	COG1652	LysM domain
TP50_RS20450	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP50_RS20450	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP50_RS20455	COG1473	amidohydrolase
TP50_RS20460	COG3039	Transposase
TP50_RS20465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_RS20470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_RS20490	COG5383	Protein conserved in bacteria
TP50_RS20530	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TP50_RS20535	COG3023	N-Acetylmuramoyl-L-alanine amidase
TP50_RS20545	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_RS20555	COG0531	amino acid
TP50_RS20570	COG4682	membrane
TP50_RS20575	COG2133	pyrroloquinoline quinone binding
TP50_RS20585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TP50_RS20590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TP50_RS20600	COG1610	YqeY-like protein
TP50_RS20610	COG1295	ribonuclease BN
TP50_RS20615	COG0358	DNA primase activity
TP50_RS20630	COG0109	protoheme IX farnesyltransferase activity
TP50_RS20660	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TP50_RS20675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TP50_RS20730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TP50_RS20735	COG0739	heme binding
TP50_RS20740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TP50_RS20750	COG2211	Major facilitator Superfamily
TP50_RS20755	COG0708	Exodeoxyribonuclease III
TP50_RS20760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TP50_RS20770	COG1192	Involved in chromosome partitioning
TP50_RS20775	COG1475	DNA binding
TP50_RS20795	COG0463	Glycosyl transferase, family 2
TP50_RS20815	COG0756	dUTP diphosphatase activity
TP50_RS20820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TP50_RS20825	COG2003	Belongs to the UPF0758 family
TP50_RS20830	COG0018	arginyl-trna synthetase
TP50_RS20845	COG4221	oxidoreductase activity
TP50_RS20850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TP50_RS20850	COG2755	lipolytic protein G-D-S-L family
TP50_RS20860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TP50_RS20865	COG1166	arginine decarboxylase activity
TP50_RS20870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TP50_RS20890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TP50_RS20890	COG3291	Pkd domain containing protein
TP50_RS20910	COG0606	chelatase, subunit chli
TP50_RS20925	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TP50_RS20965	COG1690	Belongs to the RtcB family
TP50_RS21000	COG1090	epimerase
TP50_RS21010	COG0642	Histidine kinase
TP50_RS21040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP50_RS21065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP50_RS21070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP50_RS21085	COG0753	catalase activity
TP50_RS21100	COG2197	response regulator
TP50_RS21105	COG4585	Histidine kinase
TP50_RS21110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_RS21115	COG1136	(ABC) transporter
TP50_RS21140	COG0697	spore germination
TP50_RS21160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_RS21165	COG0180	Tryptophanyl-tRNA synthetase
TP50_RS21170	COG3237	CsbD-like
TP50_RS21210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TP50_RS21295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TP50_RS21385	COG4373	Mu-like prophage FluMu protein gp28
TP50_RS21475	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TP50_RS21480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TP50_RS21480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TP50_RS21525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP50_RS21555	COG1199	ATP-dependent helicase activity
TP50_RS21570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TP50_RS21630	COG3039	Transposase
TP50_RS21675	COG1476	TRANSCRIPTIONal
TP50_RS21695	COG1230	cation diffusion facilitator family transporter
TP50_RS21700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP50_RS21705	COG1131	(ABC) transporter
TP50_RS21710	COG0842	Transport permease protein
TP50_RS21715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TP50_RS21755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP50_RS21765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP50_RS21780	COG1042	CoA-binding domain protein
TP50_RS21780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TP50_RS21780	COG0045	succinate-CoA ligase (ADP-forming) activity
TP50_RS21785	COG2239	Acts as a magnesium transporter
TP50_RS21805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP50_RS21810	COG3387	PFAM Glycoside hydrolase 15-related
TP50_RS21830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TP50_RS21840	COG0463	Glycosyl transferase, family 2
TP50_RS21850	COG3039	Transposase
TP50_RS21855	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS21890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP50_RS21905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TP50_RS21935	COG0823	Involved in the tonB-independent uptake of proteins
TP50_RS21935	COG1506	peptidase
TP50_RS21935	COG4946	Tricorn protease homolog
TP50_RS21955	COG0408	coproporphyrinogen oxidase activity
TP50_RS22000	COG0515	serine threonine protein kinase
TP50_RS22005	COG0631	protein serine/threonine phosphatase activity
TP50_RS22030	COG0667	Aldo Keto reductase
TP50_RS22035	COG0583	DNA-binding transcription factor activity
TP50_RS22075	COG1595	DNA-templated transcription, initiation
TP50_RS22195	COG0210	DNA helicase
TP50_RS22205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_RS22210	COG0583	DNA-binding transcription factor activity
TP50_RS22215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP50_RS22230	COG2159	amidohydrolase
TP50_RS22260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_RS22280	COG0357	Ribosomal RNA small subunit methyltransferase G
TP50_RS22285	COG3540	Alkaline phosphatase
TP50_RS22295	COG2091	lysine biosynthetic process via aminoadipic acid
TP50_RS22310	COG0708	Exodeoxyribonuclease III
TP50_RS22325	COG1846	Transcriptional regulator
TP50_RS22325	COG1940	carbohydrate kinase activity
TP50_RS22335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP50_RS22350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TP50_RS22355	COG3162	membrane
TP50_RS22365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TP50_RS22395	COG3507	Belongs to the glycosyl hydrolase 43 family
TP50_RS22400	COG3039	Transposase
TP50_RS22420	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS22425	COG0179	Fumarylacetoacetate (FAA) hydrolase
TP50_RS22430	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_RS22435	COG3254	rhamnose metabolic process
TP50_RS22440	COG0738	Major facilitator superfamily
TP50_RS22445	COG1414	Transcriptional regulator
TP50_RS22450	COG1971	Probably functions as a manganese efflux pump
TP50_RS22455	COG2205	protein histidine kinase activity
TP50_RS22470	COG3459	Glycosyltransferase 36 associated
TP50_RS22475	COG2211	Major facilitator Superfamily
TP50_RS22480	COG3265	gluconokinase activity
TP50_RS22490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_RS22510	COG2911	Protein conserved in bacteria
TP50_RS22515	COG0729	surface antigen
TP50_RS22535	COG3039	Transposase
TP50_RS22555	COG3039	Transposase
TP50_RS22570	COG3039	Transposase
TP50_RS22585	COG0752	glycyl-tRNA synthetase alpha subunit
TP50_RS22590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP50_RS22605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP50_RS22605	COG0519	Catalyzes the synthesis of GMP from XMP
TP50_RS22615	COG0805	protein transport
TP50_RS22620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP50_RS22625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP50_RS22635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TP50_RS22655	COG2974	May be involved in recombination
TP50_RS22660	COG0037	tRNA processing
TP50_RS22665	COG2115	Belongs to the xylose isomerase family
TP50_RS22675	COG3661	Belongs to the glycosyl hydrolase 67 family
TP50_RS22685	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_RS22695	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_RS22700	COG0246	Mannitol dehydrogenase
TP50_RS22745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP50_RS22775	COG3386	PFAM SMP-30 Gluconolaconase
TP50_RS22785	COG3250	beta-galactosidase activity
TP50_RS22790	COG1904	glucuronate isomerase
TP50_RS22795	COG3693	PFAM glycoside hydrolase, family 10
TP50_RS22805	COG3693	PFAM glycoside hydrolase, family 10
TP50_RS22820	COG2211	Major facilitator Superfamily
TP50_RS22855	COG3321	synthase
TP50_RS22855	COG0604	alcohol dehydrogenase
TP50_RS22855	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS22860	COG2937	Belongs to the GPAT DAPAT family
TP50_RS22895	COG0284	orotidine-5'-phosphate decarboxylase activity
TP50_RS22900	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
TP50_RS22910	COG3132	Protein of unknown function, DUF480
TP50_RS22925	COG0210	DNA helicase
TP50_RS22930	COG3039	Transposase
TP50_RS22935	COG1435	thymidine kinase activity
TP50_RS22945	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TP50_RS22955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TP50_RS22985	COG3135	benzoate transporter
TP50_RS23010	COG0676	glucose-6-phosphate 1-epimerase activity
TP50_RS23020	COG3012	SEC-C Motif Domain Protein
TP50_RS23025	COG0730	response to heat
TP50_RS23035	COG3039	Transposase
TP50_RS23055	COG0302	gtp cyclohydrolase
TP50_RS23070	COG1566	PFAM secretion protein HlyD family protein
TP50_RS23080	COG1289	transmembrane transporter activity
TP50_RS23085	COG0477	Major facilitator Superfamily
TP50_RS23095	COG0583	DNA-binding transcription factor activity
TP50_RS23100	COG4221	oxidoreductase activity
TP50_RS23110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_RS23115	COG3039	Transposase
TP50_RS23160	COG0439	Biotin carboxylase
TP50_RS23185	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_RS23230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TP50_RS23240	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TP50_RS23290	COG1127	ABC transporter
TP50_RS23295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP50_RS23300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP50_RS23315	COG2853	Lipoprotein
TP50_RS23325	COG0386	Belongs to the glutathione peroxidase family
TP50_RS23335	COG0386	Belongs to the glutathione peroxidase family
TP50_RS23355	COG0625	glutathione transferase activity
TP50_RS23365	COG0531	amino acid
TP50_RS23370	COG3537	Alpha-1,2-mannosidase
TP50_RS23385	COG3706	GGDEF domain
TP50_RS23390	COG3835	regulator
TP50_RS23395	COG1929	Belongs to the glycerate kinase type-1 family
TP50_RS23400	COG2271	Major facilitator Superfamily
TP50_RS23415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP50_RS23420	COG0861	Integral membrane protein TerC family
TP50_RS23430	COG0584	glycerophosphoryl diester phosphodiesterase
TP50_RS23445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TP50_RS23460	COG0706	membrane insertase activity
TP50_RS23465	COG0594	ribonuclease P activity
TP50_RS23485	COG2948	multi-organism process
TP50_RS23490	COG3504	Conjugal transfer protein
TP50_RS23550	COG1192	Involved in chromosome partitioning
TP50_RS23615	COG3077	Addiction module antitoxin, RelB DinJ family
TP50_RS23620	COG3041	Addiction module toxin RelE StbE family
TP50_RS23680	COG4453	Protein conserved in bacteria
TP50_RS23700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_RS23765	COG2337	Toxic component of a toxin-antitoxin (TA) module
TP50_RS23825	COG3504	Conjugal transfer protein
TP50_RS23860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_RS24130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone