locus-tag	class	description
XFF4834R_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFF4834R_RS00020	COG0187	DNA topoisomerase II activity
XFF4834R_RS00030	COG0501	Belongs to the peptidase M48B family
XFF4834R_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFF4834R_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFF4834R_RS00125	COG0793	Belongs to the peptidase S41A family
XFF4834R_RS00130	COG4942	peptidase
XFF4834R_RS00140	COG2234	aminopeptidase activity
XFF4834R_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFF4834R_RS00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFF4834R_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFF4834R_RS00165	COG1064	alcohol dehydrogenase
XFF4834R_RS00170	COG0493	'glutamate synthase
XFF4834R_RS00175	COG0067	glutamate synthase
XFF4834R_RS00175	COG0069	glutamate synthase activity
XFF4834R_RS00175	COG0070	glutamate synthase
XFF4834R_RS00250	COG1205	dead DEAH box helicase
XFF4834R_RS00250	COG1111	helicase
XFF4834R_RS00255	COG1272	protein, Hemolysin III
XFF4834R_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS00275	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS00300	COG2249	NAD(P)H dehydrogenase (quinone) activity
XFF4834R_RS00305	COG2963	transposase activity
XFF4834R_RS00310	COG3039	Transposase
XFF4834R_RS00315	COG3039	Transposase
XFF4834R_RS00340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XFF4834R_RS00355	COG0517	IMP dehydrogenase activity
XFF4834R_RS00355	COG1125	glycine betaine transport
XFF4834R_RS00370	COG1119	ATPase activity
XFF4834R_RS00380	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFF4834R_RS00390	COG1522	sequence-specific DNA binding
XFF4834R_RS00395	COG3186	Phenylalanine-4-hydroxylase
XFF4834R_RS00405	COG2755	lipolytic protein G-D-S-L family
XFF4834R_RS00415	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS00420	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XFF4834R_RS00425	COG1609	Transcriptional regulator
XFF4834R_RS00430	COG3507	Belongs to the glycosyl hydrolase 43 family
XFF4834R_RS00445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XFF4834R_RS00455	COG0657	acetylesterase activity
XFF4834R_RS00455	COG2755	lipolytic protein G-D-S-L family
XFF4834R_RS00475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XFF4834R_RS00480	COG0366	Alpha amylase catalytic
XFF4834R_RS00485	COG0366	Alpha amylase catalytic
XFF4834R_RS00500	COG3039	Transposase
XFF4834R_RS00510	COG3328	transposase activity
XFF4834R_RS00515	COG3328	transposase activity
XFF4834R_RS00540	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFF4834R_RS00545	COG3710	Transcriptional regulator
XFF4834R_RS00565	COG2197	response regulator
XFF4834R_RS00570	COG4585	Histidine kinase
XFF4834R_RS00580	COG1304	FMN binding
XFF4834R_RS00605	COG1012	belongs to the aldehyde dehydrogenase family
XFF4834R_RS00620	COG4772	TonB-dependent receptor
XFF4834R_RS00630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XFF4834R_RS00660	COG0714	Associated with various cellular activities
XFF4834R_RS00695	COG0477	Major facilitator Superfamily
XFF4834R_RS00700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFF4834R_RS00735	COG3039	Transposase
XFF4834R_RS00755	COG3237	CsbD-like
XFF4834R_RS00765	COG3039	Transposase
XFF4834R_RS00780	COG0489	protein tyrosine kinase activity
XFF4834R_RS00785	COG2062	phosphohistidine phosphatase, SixA
XFF4834R_RS00795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFF4834R_RS00840	COG1968	undecaprenyl-diphosphatase activity
XFF4834R_RS00845	COG0174	glutamine synthetase
XFF4834R_RS00850	COG0347	Belongs to the P(II) protein family
XFF4834R_RS00855	COG0004	ammonium transporteR
XFF4834R_RS00860	COG3852	Histidine kinase
XFF4834R_RS00865	COG2204	response regulator
XFF4834R_RS00870	COG2032	superoxide dismutase activity
XFF4834R_RS00875	COG2032	superoxide dismutase activity
XFF4834R_RS00880	COG0346	lactoylglutathione lyase activity
XFF4834R_RS00885	COG3039	Transposase
XFF4834R_RS00895	COG0183	Belongs to the thiolase family
XFF4834R_RS00930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFF4834R_RS00935	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XFF4834R_RS00940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XFF4834R_RS00950	COG0028	Belongs to the TPP enzyme family
XFF4834R_RS00955	COG2205	protein histidine kinase activity
XFF4834R_RS00980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFF4834R_RS00995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFF4834R_RS01005	COG0596	Alpha beta hydrolase
XFF4834R_RS01010	COG0727	PFAM Uncharacterised protein family (UPF0153)
XFF4834R_RS01015	COG0318	PFAM AMP-dependent synthetase and ligase
XFF4834R_RS01020	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS01030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFF4834R_RS01045	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFF4834R_RS01055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFF4834R_RS01065	COG0564	pseudouridine synthase activity
XFF4834R_RS01085	COG1446	asparaginase
XFF4834R_RS01090	COG0339	signal peptide processing
XFF4834R_RS01120	COG0475	glutathione-regulated potassium exporter activity
XFF4834R_RS01125	COG0583	DNA-binding transcription factor activity
XFF4834R_RS01130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XFF4834R_RS01135	COG2224	Isocitrate lyase
XFF4834R_RS01165	COG4770	biotin carboxylase activity
XFF4834R_RS01170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XFF4834R_RS01175	COG1960	acyl-CoA dehydrogenase activity
XFF4834R_RS01245	COG0697	spore germination
XFF4834R_RS01255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFF4834R_RS01260	COG1846	Transcriptional regulator
XFF4834R_RS01265	COG1764	response to oxidative stress
XFF4834R_RS01295	COG2130	NADP-dependent
XFF4834R_RS01310	COG1187	pseudouridine synthase activity
XFF4834R_RS01325	COG1643	Atp-dependent helicase
XFF4834R_RS01330	COG4807	Protein conserved in bacteria
XFF4834R_RS01335	COG2351	hydroxyisourate hydrolase activity
XFF4834R_RS01340	COG2072	flavoprotein involved in K transport
XFF4834R_RS01360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XFF4834R_RS01370	COG0583	DNA-binding transcription factor activity
XFF4834R_RS01405	COG2252	PERMEase
XFF4834R_RS01430	COG0084	hydrolase, TatD family'
XFF4834R_RS01440	COG0583	DNA-binding transcription factor activity
XFF4834R_RS01445	COG2814	Major facilitator Superfamily
XFF4834R_RS01455	COG2267	carboxylic ester hydrolase activity
XFF4834R_RS01460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XFF4834R_RS01465	COG1902	pentaerythritol trinitrate reductase activity
XFF4834R_RS01485	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS01490	COG2205	protein histidine kinase activity
XFF4834R_RS01495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFF4834R_RS01515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XFF4834R_RS01520	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFF4834R_RS01525	COG0583	DNA-binding transcription factor activity
XFF4834R_RS01560	COG0702	epimerase
XFF4834R_RS01565	COG1733	regulation of RNA biosynthetic process
XFF4834R_RS01595	COG3328	transposase activity
XFF4834R_RS01600	COG3039	Transposase
XFF4834R_RS01610	COG3039	Transposase
XFF4834R_RS01620	COG0129	dihydroxy-acid dehydratase activity
XFF4834R_RS01640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFF4834R_RS01695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFF4834R_RS01700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XFF4834R_RS01725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XFF4834R_RS01730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XFF4834R_RS01740	COG3485	protocatechuate 3,4-dioxygenase
XFF4834R_RS01745	COG3485	protocatechuate 3,4-dioxygenase
XFF4834R_RS01755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFF4834R_RS01760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XFF4834R_RS01770	COG1414	Transcriptional regulator
XFF4834R_RS01780	COG0657	acetylesterase activity
XFF4834R_RS01790	COG0445	tRNA wobble uridine modification
XFF4834R_RS01800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XFF4834R_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS01830	COG2267	carboxylic ester hydrolase activity
XFF4834R_RS01840	COG0156	8-amino-7-oxononanoate synthase activity
XFF4834R_RS01845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFF4834R_RS01850	COG1040	competence protein
XFF4834R_RS01855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XFF4834R_RS01875	COG3039	Transposase
XFF4834R_RS01945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XFF4834R_RS01995	COG3039	Transposase
XFF4834R_RS02020	COG1511	domain protein
XFF4834R_RS02020	COG3264	Mechanosensitive ion channel
XFF4834R_RS02025	COG1368	sulfuric ester hydrolase activity
XFF4834R_RS02030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFF4834R_RS02035	COG2354	Protein conserved in bacteria
XFF4834R_RS02045	COG0297	glycogen (starch) synthase activity
XFF4834R_RS02050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XFF4834R_RS02055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XFF4834R_RS02080	COG0702	epimerase
XFF4834R_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS02120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFF4834R_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS02135	COG0513	Belongs to the DEAD box helicase family
XFF4834R_RS02140	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFF4834R_RS02155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XFF4834R_RS02165	COG3483	tryptophan 2,3-dioxygenase activity
XFF4834R_RS02170	COG3104	oligopeptide transport
XFF4834R_RS02205	COG1320	monovalent cation:proton antiporter activity
XFF4834R_RS02210	COG2212	antiporter activity
XFF4834R_RS02220	COG0651	ATP synthesis coupled electron transport
XFF4834R_RS02225	COG1006	Multisubunit Na H antiporter MnhC subunit
XFF4834R_RS02230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XFF4834R_RS02230	COG2111	Na H antiporter
XFF4834R_RS02255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XFF4834R_RS02260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XFF4834R_RS02275	COG0456	acetyltransferase
XFF4834R_RS02310	COG3039	Transposase
XFF4834R_RS02315	COG3039	Transposase
XFF4834R_RS02335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFF4834R_RS02340	COG0134	indole-3-glycerol-phosphate synthase activity
XFF4834R_RS02350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFF4834R_RS02355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XFF4834R_RS02365	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFF4834R_RS02375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XFF4834R_RS02390	COG1051	belongs to the nudix hydrolase family
XFF4834R_RS02430	COG0316	Belongs to the HesB IscA family
XFF4834R_RS02445	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFF4834R_RS02460	COG2814	Major facilitator Superfamily
XFF4834R_RS02470	COG2814	Major facilitator Superfamily
XFF4834R_RS02475	COG1289	transmembrane transporter activity
XFF4834R_RS02485	COG0151	Belongs to the GarS family
XFF4834R_RS02495	COG0138	bifunctional purine biosynthesis protein purh
XFF4834R_RS02500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFF4834R_RS02515	COG0671	phosphoesterase, PA-phosphatase related
XFF4834R_RS02515	COG2453	phosphatase
XFF4834R_RS02540	COG4589	Belongs to the CDS family
XFF4834R_RS02545	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFF4834R_RS02570	COG2264	protein methyltransferase activity
XFF4834R_RS02585	COG0439	Biotin carboxylase
XFF4834R_RS02595	COG0511	ligase activity, forming carbon-carbon bonds
XFF4834R_RS02600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFF4834R_RS02610	COG1324	tolerance protein
XFF4834R_RS02615	COG2356	endonuclease I
XFF4834R_RS02625	COG0459	protein refolding
XFF4834R_RS02640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFF4834R_RS02655	COG3386	PFAM SMP-30 Gluconolaconase
XFF4834R_RS02665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XFF4834R_RS02670	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XFF4834R_RS02700	COG0778	Nitroreductase
XFF4834R_RS02705	COG2353	YceI-like domain
XFF4834R_RS02735	COG3052	prosthetic group binding
XFF4834R_RS02760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XFF4834R_RS02770	COG1802	Transcriptional regulator
XFF4834R_RS02815	COG3328	transposase activity
XFF4834R_RS02825	COG3039	Transposase
XFF4834R_RS02855	COG3328	transposase activity
XFF4834R_RS02880	COG4221	oxidoreductase activity
XFF4834R_RS02895	COG4221	oxidoreductase activity
XFF4834R_RS02905	COG0435	Glutathione S-transferase
XFF4834R_RS02940	COG0823	Involved in the tonB-independent uptake of proteins
XFF4834R_RS02940	COG1506	peptidase
XFF4834R_RS02970	COG0697	spore germination
XFF4834R_RS02990	COG1113	amino acid transport
XFF4834R_RS03010	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XFF4834R_RS03045	COG0840	transmembrane signaling receptor activity
XFF4834R_RS03050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFF4834R_RS03050	COG5297	Belongs to the glycosyl hydrolase family 6
XFF4834R_RS03055	COG0659	secondary active sulfate transmembrane transporter activity
XFF4834R_RS03070	COG2943	transferase activity, transferring hexosyl groups
XFF4834R_RS03080	COG3275	phosphorelay sensor kinase activity
XFF4834R_RS03090	COG0181	hydroxymethylbilane synthase activity
XFF4834R_RS03115	COG1505	serine-type exopeptidase activity
XFF4834R_RS03120	COG0436	Aminotransferase
XFF4834R_RS03130	COG2832	Protein of unknown function (DUF454)
XFF4834R_RS03140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFF4834R_RS03150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFF4834R_RS03155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XFF4834R_RS03160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFF4834R_RS03185	COG2226	methyltransferase
XFF4834R_RS03190	COG3300	MHYT domain
XFF4834R_RS03190	COG5001	Diguanylate cyclase
XFF4834R_RS03195	COG0308	aminopeptidase N
XFF4834R_RS03245	COG3284	Transcriptional regulator
XFF4834R_RS03250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFF4834R_RS03255	COG1077	Cell shape determining protein MreB Mrl
XFF4834R_RS03260	COG1792	Involved in formation and maintenance of cell shape
XFF4834R_RS03275	COG0772	Belongs to the SEDS family
XFF4834R_RS03285	COG2951	lytic endotransglycosylase activity
XFF4834R_RS03290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XFF4834R_RS03295	COG1686	Belongs to the peptidase S11 family
XFF4834R_RS03305	COG2921	Belongs to the UPF0250 family
XFF4834R_RS03310	COG0321	lipoyl(octanoyl) transferase activity
XFF4834R_RS03315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFF4834R_RS03340	COG1056	cytidyltransferase-related domain
XFF4834R_RS03340	COG1051	belongs to the nudix hydrolase family
XFF4834R_RS03375	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XFF4834R_RS03380	COG0673	inositol 2-dehydrogenase activity
XFF4834R_RS03385	COG2823	Periplasmic or secreted lipoprotein
XFF4834R_RS03390	COG4251	negative regulation of phosphorylation
XFF4834R_RS03395	COG0784	Response regulator, receiver
XFF4834R_RS03400	COG4191	Histidine kinase
XFF4834R_RS03405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFF4834R_RS03460	COG1459	type II secretion system
XFF4834R_RS03465	COG2165	general secretion pathway protein
XFF4834R_RS03480	COG4795	General secretion pathway protein
XFF4834R_RS03510	COG3250	beta-galactosidase activity
XFF4834R_RS03525	COG2188	Transcriptional regulator
XFF4834R_RS03535	COG1609	Transcriptional regulator
XFF4834R_RS03540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFF4834R_RS03545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFF4834R_RS03560	COG0617	tRNA 3'-terminal CCA addition
XFF4834R_RS03565	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XFF4834R_RS03570	COG1012	belongs to the aldehyde dehydrogenase family
XFF4834R_RS03575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XFF4834R_RS03585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFF4834R_RS03600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFF4834R_RS03625	COG2205	protein histidine kinase activity
XFF4834R_RS03655	COG3791	Glutathione-dependent formaldehyde-activating
XFF4834R_RS03665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XFF4834R_RS03685	COG0488	(ABC) transporter
XFF4834R_RS03695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFF4834R_RS03700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFF4834R_RS03710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFF4834R_RS03710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFF4834R_RS03730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XFF4834R_RS03735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFF4834R_RS03740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFF4834R_RS03760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XFF4834R_RS03765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XFF4834R_RS03770	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XFF4834R_RS03775	COG2205	protein histidine kinase activity
XFF4834R_RS03780	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS03785	COG0277	FAD linked oxidase domain protein
XFF4834R_RS03790	COG1988	membrane-bound metal-dependent
XFF4834R_RS03795	COG0792	nuclease activity
XFF4834R_RS03820	COG0275	rRNA processing
XFF4834R_RS03825	COG3116	cell division
XFF4834R_RS03835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFF4834R_RS03840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFF4834R_RS03845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFF4834R_RS03855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFF4834R_RS03860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFF4834R_RS03865	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFF4834R_RS03870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFF4834R_RS03885	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFF4834R_RS03895	COG0739	heme binding
XFF4834R_RS03900	COG0653	protein targeting
XFF4834R_RS03905	COG0494	nUDIX hydrolase
XFF4834R_RS03915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XFF4834R_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS03925	COG3321	synthase
XFF4834R_RS03925	COG0604	alcohol dehydrogenase
XFF4834R_RS03945	COG0366	Alpha amylase catalytic
XFF4834R_RS03980	COG2226	methyltransferase
XFF4834R_RS03985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XFF4834R_RS03995	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XFF4834R_RS04035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFF4834R_RS04045	COG4106	trans-aconitate 2-methyltransferase activity
XFF4834R_RS04050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XFF4834R_RS04060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFF4834R_RS04065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XFF4834R_RS04075	COG0667	Aldo Keto reductase
XFF4834R_RS04085	COG4771	TonB-dependent receptor
XFF4834R_RS04105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XFF4834R_RS04110	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XFF4834R_RS04120	COG2175	clavaminate synthase activity
XFF4834R_RS04130	COG4181	ATPase activity
XFF4834R_RS04145	COG0642	Histidine kinase
XFF4834R_RS04155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFF4834R_RS04175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFF4834R_RS04180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFF4834R_RS04195	COG3829	transcription factor binding
XFF4834R_RS04205	COG1116	anion transmembrane transporter activity
XFF4834R_RS04210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XFF4834R_RS04220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFF4834R_RS04225	COG0431	NADPH-dependent FMN reductase
XFF4834R_RS04245	COG0747	negative chemotaxis
XFF4834R_RS04255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XFF4834R_RS04265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFF4834R_RS04270	COG2967	ApaG domain
XFF4834R_RS04275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFF4834R_RS04280	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFF4834R_RS04285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFF4834R_RS04290	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XFF4834R_RS04300	COG0123	including yeast histone deacetylase and acetoin utilization protein
XFF4834R_RS04305	COG2096	Adenosyltransferase
XFF4834R_RS04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFF4834R_RS04320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFF4834R_RS04350	COG3384	dioxygenase
XFF4834R_RS04355	COG0583	DNA-binding transcription factor activity
XFF4834R_RS04370	COG1024	Enoyl-CoA hydratase
XFF4834R_RS04395	COG3039	Transposase
XFF4834R_RS04410	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFF4834R_RS04435	COG0697	spore germination
XFF4834R_RS04445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFF4834R_RS04470	COG2197	response regulator
XFF4834R_RS04480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFF4834R_RS04490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XFF4834R_RS04495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFF4834R_RS04500	COG0583	DNA-binding transcription factor activity
XFF4834R_RS04505	COG3634	alkyl hydroperoxide reductase activity
XFF4834R_RS04515	COG2890	protein-(glutamine-N5) methyltransferase activity
XFF4834R_RS04535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XFF4834R_RS04535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XFF4834R_RS04555	COG3039	Transposase
XFF4834R_RS04570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XFF4834R_RS04610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFF4834R_RS04615	COG1404	Belongs to the peptidase S8 family
XFF4834R_RS04620	COG1404	Belongs to the peptidase S8 family
XFF4834R_RS04625	COG1404	Belongs to the peptidase S8 family
XFF4834R_RS04630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XFF4834R_RS04655	COG1295	ribonuclease BN
XFF4834R_RS04660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFF4834R_RS04665	COG1254	Belongs to the acylphosphatase family
XFF4834R_RS04680	COG0521	Mo-molybdopterin cofactor biosynthetic process
XFF4834R_RS04690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFF4834R_RS04695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFF4834R_RS04705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFF4834R_RS04710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFF4834R_RS04720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XFF4834R_RS04725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XFF4834R_RS04730	COG0193	aminoacyl-tRNA hydrolase activity
XFF4834R_RS04735	COG0012	GTP binding
XFF4834R_RS04755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFF4834R_RS04770	COG0250	Participates in transcription elongation, termination and antitermination
XFF4834R_RS04775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFF4834R_RS04780	COG0081	regulation of translation
XFF4834R_RS04785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFF4834R_RS04790	COG0222	ribosome binding
XFF4834R_RS04795	COG0085	RNA polymerase activity
XFF4834R_RS04800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFF4834R_RS04805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XFF4834R_RS04810	COG0049	tRNA binding
XFF4834R_RS04815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFF4834R_RS04820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFF4834R_RS04825	COG0051	transcription antitermination factor activity, RNA binding
XFF4834R_RS04830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFF4834R_RS04835	COG0088	Forms part of the polypeptide exit tunnel
XFF4834R_RS04840	COG0089	rRNA binding
XFF4834R_RS04845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFF4834R_RS04850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XFF4834R_RS04860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFF4834R_RS04865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XFF4834R_RS04870	COG0255	Belongs to the universal ribosomal protein uL29 family
XFF4834R_RS04875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFF4834R_RS04885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFF4834R_RS04890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFF4834R_RS04900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFF4834R_RS04905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFF4834R_RS04910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XFF4834R_RS04920	COG1841	ribosomal large subunit assembly
XFF4834R_RS04925	COG0200	Binds to the 23S rRNA
XFF4834R_RS04930	COG0201	protein transport
XFF4834R_RS04955	COG0203	ribosomal protein L17
XFF4834R_RS04960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFF4834R_RS04975	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XFF4834R_RS04985	COG0154	amidase activity
XFF4834R_RS04995	COG1217	gtp-binding protein TYPA
XFF4834R_RS05000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFF4834R_RS05005	COG0039	L-malate dehydrogenase activity
XFF4834R_RS05010	COG0625	glutathione transferase activity
XFF4834R_RS05020	COG0446	pyridine nucleotide-disulphide oxidoreductase
XFF4834R_RS05020	COG1902	pentaerythritol trinitrate reductase activity
XFF4834R_RS05025	COG0604	alcohol dehydrogenase
XFF4834R_RS05050	COG0156	8-amino-7-oxononanoate synthase activity
XFF4834R_RS05060	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFF4834R_RS05065	COG4208	sulfate ABC transporter
XFF4834R_RS05070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFF4834R_RS05100	COG0406	alpha-ribazole phosphatase activity
XFF4834R_RS05105	COG0285	dihydrofolate synthase activity
XFF4834R_RS05125	COG2833	Protein of unknown function (DUF455)
XFF4834R_RS05140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFF4834R_RS05145	COG0671	phosphoesterase, PA-phosphatase related
XFF4834R_RS05150	COG0438	transferase activity, transferring glycosyl groups
XFF4834R_RS05160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFF4834R_RS05175	COG4783	chaperone-mediated protein folding
XFF4834R_RS05190	COG0473	3-isopropylmalate dehydrogenase activity
XFF4834R_RS05230	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFF4834R_RS05240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFF4834R_RS05270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFF4834R_RS05280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFF4834R_RS05290	COG0328	RNA-DNA hybrid ribonuclease activity
XFF4834R_RS05295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFF4834R_RS05300	COG0631	protein serine/threonine phosphatase activity
XFF4834R_RS05315	COG0859	PFAM glycosyl transferase family 9
XFF4834R_RS05320	COG3642	lipopolysaccharide core region biosynthetic process
XFF4834R_RS05325	COG1234	tRNA 3'-trailer cleavage
XFF4834R_RS05330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XFF4834R_RS05340	COG0315	cyclic pyranopterin monophosphate synthase activity
XFF4834R_RS05345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XFF4834R_RS05350	COG0314	molybdopterin synthase activity
XFF4834R_RS05375	COG3039	Transposase
XFF4834R_RS05385	COG3039	Transposase
XFF4834R_RS05390	COG3328	transposase activity
XFF4834R_RS05410	COG3328	transposase activity
XFF4834R_RS05440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFF4834R_RS05445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XFF4834R_RS05450	COG0537	adenosine 5'-monophosphoramidase activity
XFF4834R_RS05470	COG0714	Associated with various cellular activities
XFF4834R_RS05490	COG0424	maF-like protein
XFF4834R_RS05495	COG1399	metal-binding, possibly nucleic acid-binding protein
XFF4834R_RS05505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFF4834R_RS05515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XFF4834R_RS05520	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS05535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFF4834R_RS05540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFF4834R_RS05565	COG3829	transcription factor binding
XFF4834R_RS05600	COG3039	Transposase
XFF4834R_RS05620	COG0402	S-adenosylhomocysteine deaminase activity
XFF4834R_RS05625	COG3964	amidohydrolase
XFF4834R_RS05640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFF4834R_RS05645	COG0726	polysaccharide deacetylase
XFF4834R_RS05660	COG0436	Aminotransferase
XFF4834R_RS05665	COG1162	GTPase activity
XFF4834R_RS05690	COG2211	Major facilitator Superfamily
XFF4834R_RS05695	COG1609	Transcriptional regulator
XFF4834R_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS05705	COG2851	Citrate transporter
XFF4834R_RS05720	COG0642	Histidine kinase
XFF4834R_RS05730	COG2197	response regulator
XFF4834R_RS05745	COG0667	Aldo Keto reductase
XFF4834R_RS05755	COG0583	DNA-binding transcription factor activity
XFF4834R_RS05780	COG1301	dicarboxylic acid transport
XFF4834R_RS05785	COG0280	phosphate acetyltransferase
XFF4834R_RS05785	COG0281	malic enzyme
XFF4834R_RS05810	COG1560	Kdo2-lipid A biosynthetic process
XFF4834R_RS05815	COG1519	Transferase
XFF4834R_RS05820	COG1538	Outer membrane efflux protein
XFF4834R_RS05825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFF4834R_RS05845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFF4834R_RS05850	COG0066	3-isopropylmalate dehydratase activity
XFF4834R_RS05855	COG0473	3-isopropylmalate dehydrogenase activity
XFF4834R_RS05860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFF4834R_RS05880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFF4834R_RS05885	COG0405	Gamma-glutamyltransferase
XFF4834R_RS05890	COG0840	transmembrane signaling receptor activity
XFF4834R_RS05900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XFF4834R_RS05925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFF4834R_RS05935	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XFF4834R_RS05950	COG0563	adenylate kinase activity
XFF4834R_RS05955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFF4834R_RS05965	COG3781	membrane
XFF4834R_RS05970	COG0671	phosphoesterase, PA-phosphatase related
XFF4834R_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS05985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFF4834R_RS05990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XFF4834R_RS06020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XFF4834R_RS06035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFF4834R_RS06045	COG0352	thiamine-phosphate diphosphorylase activity
XFF4834R_RS06050	COG1773	rubredoxin
XFF4834R_RS06055	COG2912	Transglutaminase-like superfamily
XFF4834R_RS06065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFF4834R_RS06075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFF4834R_RS06090	COG3079	Belongs to the UPF0149 family
XFF4834R_RS06095	COG0006	proline dipeptidase activity
XFF4834R_RS06105	COG0006	proline dipeptidase activity
XFF4834R_RS06120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFF4834R_RS06125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFF4834R_RS06135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XFF4834R_RS06140	COG1561	YicC-like family, N-terminal region
XFF4834R_RS06155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFF4834R_RS06160	COG0583	DNA-binding transcription factor activity
XFF4834R_RS06175	COG2271	Major facilitator Superfamily
XFF4834R_RS06190	COG2721	sulfolactate sulfo-lyase activity
XFF4834R_RS06200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFF4834R_RS06225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFF4834R_RS06255	COG0714	Associated with various cellular activities
XFF4834R_RS06275	COG2304	oxidoreductase activity
XFF4834R_RS06285	COG1301	dicarboxylic acid transport
XFF4834R_RS06295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFF4834R_RS06315	COG4773	Receptor
XFF4834R_RS06320	COG0739	heme binding
XFF4834R_RS06325	COG1376	ErfK ybiS ycfS ynhG family protein
XFF4834R_RS06360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XFF4834R_RS06365	COG4149	molybdate abc transporter
XFF4834R_RS06370	COG0725	ABC transporter, periplasmic molybdate-binding protein
XFF4834R_RS06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFF4834R_RS06375	COG3453	Protein conserved in bacteria
XFF4834R_RS06385	COG3047	cAMP biosynthetic process
XFF4834R_RS06390	COG3047	cAMP biosynthetic process
XFF4834R_RS06400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFF4834R_RS06420	COG0126	phosphoglycerate kinase activity
XFF4834R_RS06430	COG0469	pyruvate kinase activity
XFF4834R_RS06435	COG3588	fructose-bisphosphate aldolase
XFF4834R_RS06440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XFF4834R_RS06460	COG0583	DNA-binding transcription factor activity
XFF4834R_RS06470	COG0784	Response regulator, receiver
XFF4834R_RS06470	COG2198	Histidine kinase
XFF4834R_RS06470	COG2205	protein histidine kinase activity
XFF4834R_RS06490	COG3039	Transposase
XFF4834R_RS06500	COG0175	sulfate reduction
XFF4834R_RS06505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFF4834R_RS06510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XFF4834R_RS06515	COG0175	sulfate reduction
XFF4834R_RS06520	COG0529	Catalyzes the synthesis of activated sulfate
XFF4834R_RS06520	COG2895	sulfate adenylyltransferase (ATP) activity
XFF4834R_RS06530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFF4834R_RS06535	COG0308	aminopeptidase N
XFF4834R_RS06545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFF4834R_RS06555	COG4948	Mandelate Racemase Muconate Lactonizing
XFF4834R_RS06560	COG3250	beta-galactosidase activity
XFF4834R_RS06570	COG1609	Transcriptional regulator
XFF4834R_RS06585	COG1970	mechanosensitive ion channel activity
XFF4834R_RS06610	COG3273	potassium ion transport
XFF4834R_RS06610	COG0471	metal ion transport
XFF4834R_RS06615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFF4834R_RS06620	COG2022	thiamine diphosphate biosynthetic process
XFF4834R_RS06705	COG3328	transposase activity
XFF4834R_RS06710	COG1002	Type II restriction enzyme, methylase subunits
XFF4834R_RS06715	COG1061	Type III restriction enzyme res subunit
XFF4834R_RS06720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFF4834R_RS06730	COG3328	transposase activity
XFF4834R_RS06740	COG1396	sequence-specific DNA binding
XFF4834R_RS06790	COG3328	transposase activity
XFF4834R_RS06815	COG0189	ligase activity
XFF4834R_RS06825	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS06840	COG3039	Transposase
XFF4834R_RS06850	COG3328	transposase activity
XFF4834R_RS06860	COG0237	dephospho-CoA kinase activity
XFF4834R_RS06865	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFF4834R_RS06870	COG1459	type II secretion system
XFF4834R_RS06905	COG0045	succinate-CoA ligase (ADP-forming) activity
XFF4834R_RS06910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFF4834R_RS06920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XFF4834R_RS06920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XFF4834R_RS06930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFF4834R_RS06935	COG0564	pseudouridine synthase activity
XFF4834R_RS06950	COG3011	Protein conserved in bacteria
XFF4834R_RS06955	COG0840	transmembrane signaling receptor activity
XFF4834R_RS06970	COG3387	PFAM Glycoside hydrolase 15-related
XFF4834R_RS06975	COG1877	trehalose-phosphatase activity
XFF4834R_RS07015	COG2827	Endonuclease containing a URI domain
XFF4834R_RS07020	COG4771	TonB-dependent receptor
XFF4834R_RS07025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFF4834R_RS07030	COG0667	Aldo Keto reductase
XFF4834R_RS07035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XFF4834R_RS07040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XFF4834R_RS07045	COG1116	anion transmembrane transporter activity
XFF4834R_RS07050	COG0542	response to heat
XFF4834R_RS07060	COG4206	TonB-dependent receptor
XFF4834R_RS07085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFF4834R_RS07095	COG1492	cobalamin metabolic process
XFF4834R_RS07105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XFF4834R_RS07130	COG0019	diaminopimelate decarboxylase activity
XFF4834R_RS07145	COG4264	IucA IucC family
XFF4834R_RS07155	COG4772	TonB-dependent receptor
XFF4834R_RS07165	COG4651	solute:proton antiporter activity
XFF4834R_RS07165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFF4834R_RS07195	COG0488	(ABC) transporter
XFF4834R_RS07230	COG0477	Major facilitator Superfamily
XFF4834R_RS07245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFF4834R_RS07260	COG0217	transcriptional regulatory protein
XFF4834R_RS07265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFF4834R_RS07270	COG0632	four-way junction helicase activity
XFF4834R_RS07275	COG3158	transport of potassium into the cell
XFF4834R_RS07280	COG2255	four-way junction helicase activity
XFF4834R_RS07285	COG0824	Thioesterase
XFF4834R_RS07295	COG0848	biopolymer transport protein
XFF4834R_RS07305	COG0823	Involved in the tonB-independent uptake of proteins
XFF4834R_RS07310	COG2885	chlorophyll binding
XFF4834R_RS07320	COG0602	queuosine metabolic process
XFF4834R_RS07330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFF4834R_RS07335	COG3920	Histidine kinase
XFF4834R_RS07355	COG0840	transmembrane signaling receptor activity
XFF4834R_RS07400	COG0514	ATP-dependent DNA helicase (RecQ)
XFF4834R_RS07405	COG0783	Belongs to the Dps family
XFF4834R_RS07410	COG1643	Atp-dependent helicase
XFF4834R_RS07420	COG0837	glucose binding
XFF4834R_RS07435	COG0535	radical SAM domain protein
XFF4834R_RS07440	COG0535	radical SAM domain protein
XFF4834R_RS07445	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XFF4834R_RS07450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XFF4834R_RS07455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFF4834R_RS07465	COG1215	transferase activity, transferring glycosyl groups
XFF4834R_RS07470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFF4834R_RS07480	COG1199	ATP-dependent helicase activity
XFF4834R_RS07490	COG1397	ADP-ribosylglycohydrolase
XFF4834R_RS07500	COG0189	ligase activity
XFF4834R_RS07515	COG0835	chemotaxis
XFF4834R_RS07520	COG0840	transmembrane signaling receptor activity
XFF4834R_RS07525	COG0784	Response regulator, receiver
XFF4834R_RS07525	COG0643	Histidine kinase
XFF4834R_RS07525	COG2198	Histidine kinase
XFF4834R_RS07550	COG1446	asparaginase
XFF4834R_RS07555	COG3142	Participates in the control of copper homeostasis
XFF4834R_RS07595	COG3537	Alpha-1,2-mannosidase
XFF4834R_RS07605	COG1486	melibiose metabolic process
XFF4834R_RS07615	COG0531	amino acid
XFF4834R_RS07640	COG1472	Belongs to the glycosyl hydrolase 3 family
XFF4834R_RS07650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFF4834R_RS07655	COG3858	chitin binding
XFF4834R_RS07655	COG1388	LysM domain
XFF4834R_RS07670	COG0837	glucose binding
XFF4834R_RS07675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFF4834R_RS07685	COG0494	nUDIX hydrolase
XFF4834R_RS07690	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFF4834R_RS07695	COG3956	TIGRFAM MazG family protein
XFF4834R_RS07700	COG1742	UPF0060 membrane protein
XFF4834R_RS07710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XFF4834R_RS07715	COG0509	glycine decarboxylation via glycine cleavage system
XFF4834R_RS07755	COG1960	acyl-CoA dehydrogenase activity
XFF4834R_RS07765	COG1309	transcriptional regulator
XFF4834R_RS07770	COG3039	Transposase
XFF4834R_RS07780	COG4771	TonB-dependent receptor
XFF4834R_RS07790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XFF4834R_RS07795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFF4834R_RS07800	COG0463	Glycosyl transferase, family 2
XFF4834R_RS07805	COG0516	GMP reductase activity
XFF4834R_RS07805	COG0517	IMP dehydrogenase activity
XFF4834R_RS07810	COG2982	Protein involved in outer membrane biogenesis
XFF4834R_RS07815	COG1272	protein, Hemolysin III
XFF4834R_RS07820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFF4834R_RS07825	COG0739	heme binding
XFF4834R_RS07830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFF4834R_RS07835	COG0626	cystathionine gamma-synthase activity
XFF4834R_RS07840	COG0460	homoserine dehydrogenase
XFF4834R_RS07840	COG0527	aspartate kinase activity
XFF4834R_RS07850	COG1760	l-serine dehydratase
XFF4834R_RS07870	COG2353	YceI-like domain
XFF4834R_RS07875	COG2198	Histidine kinase
XFF4834R_RS07875	COG2205	protein histidine kinase activity
XFF4834R_RS07875	COG0784	Response regulator, receiver
XFF4834R_RS07895	COG2814	Major facilitator Superfamily
XFF4834R_RS07900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFF4834R_RS07910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XFF4834R_RS07915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFF4834R_RS07920	COG0259	pyridoxamine-phosphate oxidase activity
XFF4834R_RS07930	COG1842	Phage shock protein A
XFF4834R_RS07955	COG0754	glutathionylspermidine amidase activity
XFF4834R_RS07960	COG2814	Major facilitator Superfamily
XFF4834R_RS08020	COG0531	amino acid
XFF4834R_RS08025	COG2197	response regulator
XFF4834R_RS08045	COG3328	transposase activity
XFF4834R_RS08050	COG1113	amino acid transport
XFF4834R_RS08060	COG1271	oxidase subunit
XFF4834R_RS08065	COG1294	oxidase, subunit
XFF4834R_RS08075	COG2239	Acts as a magnesium transporter
XFF4834R_RS08080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFF4834R_RS08085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFF4834R_RS08095	COG1660	Displays ATPase and GTPase activities
XFF4834R_RS08100	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XFF4834R_RS08105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFF4834R_RS08120	COG1137	ATPase activity
XFF4834R_RS08125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XFF4834R_RS08135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFF4834R_RS08145	COG0271	Belongs to the BolA IbaG family
XFF4834R_RS08150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFF4834R_RS08170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFF4834R_RS08180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFF4834R_RS08190	COG0628	permease
XFF4834R_RS08200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFF4834R_RS08205	COG3178	'Phosphotransferase
XFF4834R_RS08220	COG1555	photosystem II stabilization
XFF4834R_RS08230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XFF4834R_RS08235	COG1477	protein flavinylation
XFF4834R_RS08260	COG3128	pkhd-type hydroxylase
XFF4834R_RS08265	COG4774	siderophore transport
XFF4834R_RS08270	COG2146	nitrite reductase [NAD(P)H] activity
XFF4834R_RS08280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFF4834R_RS08285	COG0719	Fe-S assembly protein
XFF4834R_RS08290	COG0396	ATPase activity
XFF4834R_RS08295	COG0719	Fe-S assembly protein
XFF4834R_RS08300	COG1959	2 iron, 2 sulfur cluster binding
XFF4834R_RS08310	COG0693	protein deglycase activity
XFF4834R_RS08330	COG0739	heme binding
XFF4834R_RS08345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFF4834R_RS08370	COG0519	Catalyzes the synthesis of GMP from XMP
XFF4834R_RS08380	COG1678	Uncharacterized ACR, COG1678
XFF4834R_RS08385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XFF4834R_RS08390	COG0540	Belongs to the ATCase OTCase family
XFF4834R_RS08395	COG1764	response to oxidative stress
XFF4834R_RS08405	COG0384	phenazine biosynthesis protein PhzF
XFF4834R_RS08410	COG0384	phenazine biosynthesis protein PhzF
XFF4834R_RS08415	COG0527	aspartate kinase activity
XFF4834R_RS08430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XFF4834R_RS08440	COG0142	geranyltranstransferase activity
XFF4834R_RS08445	COG0629	single-stranded DNA binding
XFF4834R_RS08450	COG2203	Gaf domain
XFF4834R_RS08450	COG3706	GGDEF domain
XFF4834R_RS08450	COG4251	negative regulation of phosphorylation
XFF4834R_RS08450	COG5001	Diguanylate cyclase
XFF4834R_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS08455	COG3321	synthase
XFF4834R_RS08455	COG0604	alcohol dehydrogenase
XFF4834R_RS08460	COG2080	2 iron, 2 sulfur cluster binding
XFF4834R_RS08465	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XFF4834R_RS08470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XFF4834R_RS08475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XFF4834R_RS08520	COG2879	small protein
XFF4834R_RS08525	COG1966	Carbon starvation protein
XFF4834R_RS08530	COG1741	Belongs to the pirin family
XFF4834R_RS08545	COG1741	Belongs to the pirin family
XFF4834R_RS08550	COG3328	transposase activity
XFF4834R_RS08560	COG1515	deoxyribonuclease V activity
XFF4834R_RS08565	COG0588	phosphoglycerate mutase activity
XFF4834R_RS08575	COG3590	peptidase
XFF4834R_RS08580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFF4834R_RS08585	COG2201	protein-glutamate methylesterase activity
XFF4834R_RS08590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XFF4834R_RS08595	COG2202	Pas domain
XFF4834R_RS08595	COG2200	EAL domain
XFF4834R_RS08595	COG2199	diguanylate cyclase activity
XFF4834R_RS08600	COG0835	chemotaxis
XFF4834R_RS08605	COG0840	transmembrane signaling receptor activity
XFF4834R_RS08610	COG2198	Histidine kinase
XFF4834R_RS08610	COG0643	Histidine kinase
XFF4834R_RS08620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFF4834R_RS08630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFF4834R_RS08635	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS08640	COG2205	protein histidine kinase activity
XFF4834R_RS08655	COG4452	Inner membrane protein CreD
XFF4834R_RS08680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFF4834R_RS08685	COG0735	belongs to the Fur family
XFF4834R_RS08700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFF4834R_RS08710	COG1309	transcriptional regulator
XFF4834R_RS08720	COG2207	Transcriptional regulator
XFF4834R_RS08730	COG0583	DNA-binding transcription factor activity
XFF4834R_RS08735	COG2814	Major facilitator Superfamily
XFF4834R_RS08740	COG0667	Aldo Keto reductase
XFF4834R_RS08835	COG1595	DNA-templated transcription, initiation
XFF4834R_RS08845	COG5001	Diguanylate cyclase
XFF4834R_RS08845	COG5002	protein histidine kinase activity
XFF4834R_RS08850	COG1187	pseudouridine synthase activity
XFF4834R_RS08875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XFF4834R_RS08885	COG0475	glutathione-regulated potassium exporter activity
XFF4834R_RS08890	COG5000	phosphorelay sensor kinase activity
XFF4834R_RS08890	COG5002	protein histidine kinase activity
XFF4834R_RS08895	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS08900	COG1538	Outer membrane efflux protein
XFF4834R_RS08925	COG1132	(ABC) transporter
XFF4834R_RS08970	COG2155	Conserved Protein
XFF4834R_RS09005	COG3118	belongs to the thioredoxin family
XFF4834R_RS09015	COG0495	leucyl-tRNA aminoacylation
XFF4834R_RS09030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFF4834R_RS09045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XFF4834R_RS09060	COG2968	Membrane
XFF4834R_RS09065	COG0424	maF-like protein
XFF4834R_RS09075	COG3164	Protein of unknown function
XFF4834R_RS09085	COG0312	modulator of DNA gyrase
XFF4834R_RS09090	COG3028	Belongs to the UPF0307 family
XFF4834R_RS09095	COG0312	modulator of DNA gyrase
XFF4834R_RS09105	COG4104	PAAR repeat-containing protein
XFF4834R_RS09110	COG0142	geranyltranstransferase activity
XFF4834R_RS09115	COG1722	exodeoxyribonuclease VII activity
XFF4834R_RS09120	COG0037	tRNA processing
XFF4834R_RS09125	COG1785	Belongs to the alkaline phosphatase family
XFF4834R_RS09130	COG1301	dicarboxylic acid transport
XFF4834R_RS09135	COG4106	trans-aconitate 2-methyltransferase activity
XFF4834R_RS09145	COG0791	NLP P60 protein
XFF4834R_RS09150	COG0791	NLP P60 protein
XFF4834R_RS09155	COG1047	Peptidyl-prolyl cis-trans
XFF4834R_RS09160	COG2311	Membrane
XFF4834R_RS09165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFF4834R_RS09170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XFF4834R_RS09190	COG3590	peptidase
XFF4834R_RS09195	COG3590	peptidase
XFF4834R_RS09205	COG3039	Transposase
XFF4834R_RS09220	COG0489	protein tyrosine kinase activity
XFF4834R_RS09225	COG0717	Belongs to the dCTP deaminase family
XFF4834R_RS09270	COG3328	transposase activity
XFF4834R_RS09285	COG0860	N-Acetylmuramoyl-L-alanine amidase
XFF4834R_RS09290	COG1469	GTP cyclohydrolase I activity
XFF4834R_RS09310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFF4834R_RS09315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XFF4834R_RS09320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XFF4834R_RS09345	COG1472	Belongs to the glycosyl hydrolase 3 family
XFF4834R_RS09355	COG3706	GGDEF domain
XFF4834R_RS09355	COG2203	Gaf domain
XFF4834R_RS09355	COG5001	Diguanylate cyclase
XFF4834R_RS09355	COG4251	negative regulation of phosphorylation
XFF4834R_RS09360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFF4834R_RS09365	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFF4834R_RS09375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFF4834R_RS09390	COG1794	racemase activity, acting on amino acids and derivatives
XFF4834R_RS09395	COG0697	spore germination
XFF4834R_RS09400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFF4834R_RS09405	COG0167	dihydroorotate dehydrogenase activity
XFF4834R_RS09420	COG1012	belongs to the aldehyde dehydrogenase family
XFF4834R_RS09435	COG1215	transferase activity, transferring glycosyl groups
XFF4834R_RS09440	COG0726	polysaccharide deacetylase
XFF4834R_RS09440	COG1649	PFAM Uncharacterised BCR, COG1649
XFF4834R_RS09460	COG3328	transposase activity
XFF4834R_RS09465	COG3039	Transposase
XFF4834R_RS09470	COG3039	Transposase
XFF4834R_RS09480	COG3210	domain, Protein
XFF4834R_RS09485	COG3039	Transposase
XFF4834R_RS09500	COG3328	transposase activity
XFF4834R_RS09505	COG2963	transposase activity
XFF4834R_RS09540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFF4834R_RS09545	COG0124	histidyl-tRNA synthetase
XFF4834R_RS09555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFF4834R_RS09560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XFF4834R_RS09565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XFF4834R_RS09570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFF4834R_RS09570	COG0131	Imidazoleglycerol-phosphate dehydratase
XFF4834R_RS09575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XFF4834R_RS09580	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFF4834R_RS09585	COG0107	imidazoleglycerol-phosphate synthase activity
XFF4834R_RS09590	COG0140	phosphoribosyl-ATP diphosphatase activity
XFF4834R_RS09590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XFF4834R_RS09605	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFF4834R_RS09610	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFF4834R_RS09615	COG0235	Class ii aldolase
XFF4834R_RS09620	COG0531	amino acid
XFF4834R_RS09625	COG0531	amino acid
XFF4834R_RS09635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFF4834R_RS09640	COG0277	FAD linked oxidase domain protein
XFF4834R_RS09660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFF4834R_RS09705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XFF4834R_RS09710	COG2258	MOSC domain
XFF4834R_RS09715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFF4834R_RS09720	COG0505	Belongs to the CarA family
XFF4834R_RS09730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XFF4834R_RS09735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFF4834R_RS09745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFF4834R_RS09755	COG3279	Response regulator of the LytR AlgR family
XFF4834R_RS09760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFF4834R_RS09765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XFF4834R_RS09775	COG2205	protein histidine kinase activity
XFF4834R_RS09775	COG0784	Response regulator, receiver
XFF4834R_RS09775	COG2198	Histidine kinase
XFF4834R_RS09780	COG2205	protein histidine kinase activity
XFF4834R_RS09780	COG0784	Response regulator, receiver
XFF4834R_RS09780	COG2198	Histidine kinase
XFF4834R_RS09785	COG1024	Enoyl-CoA hydratase
XFF4834R_RS09790	COG0318	PFAM AMP-dependent synthetase and ligase
XFF4834R_RS09825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFF4834R_RS09835	COG2201	protein-glutamate methylesterase activity
XFF4834R_RS09840	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XFF4834R_RS09850	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09860	COG0835	chemotaxis
XFF4834R_RS09875	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09880	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09885	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09890	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09900	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09910	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09915	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09920	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09935	COG0840	transmembrane signaling receptor activity
XFF4834R_RS09945	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS09955	COG0835	chemotaxis
XFF4834R_RS09965	COG1360	Flagellar Motor Protein
XFF4834R_RS09970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XFF4834R_RS09985	COG3328	transposase activity
XFF4834R_RS09990	COG0643	Histidine kinase
XFF4834R_RS09990	COG2198	Histidine kinase
XFF4834R_RS09990	COG0784	Response regulator, receiver
XFF4834R_RS10020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XFF4834R_RS10050	COG1684	flagellar biosynthetic protein fliR
XFF4834R_RS10065	COG3190	flagellar
XFF4834R_RS10115	COG1677	Flagellar hook-basal body complex protein FliE
XFF4834R_RS10125	COG3039	Transposase
XFF4834R_RS10145	COG5002	protein histidine kinase activity
XFF4834R_RS10175	COG2915	High frequency lysogenization protein hflD homolog
XFF4834R_RS10180	COG0482	sulfurtransferase activity
XFF4834R_RS10195	COG0542	response to heat
XFF4834R_RS10205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFF4834R_RS10215	COG0492	ferredoxin-NADP+ reductase activity
XFF4834R_RS10220	COG1674	ftsk spoiiie
XFF4834R_RS10230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFF4834R_RS10240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFF4834R_RS10245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFF4834R_RS10250	COG0183	Belongs to the thiolase family
XFF4834R_RS10255	COG1024	Enoyl-CoA hydratase
XFF4834R_RS10255	COG1250	3-hydroxyacyl-CoA dehydrogenase
XFF4834R_RS10270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFF4834R_RS10280	COG1426	Protein conserved in bacteria
XFF4834R_RS10290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFF4834R_RS10295	COG1160	GTP binding
XFF4834R_RS10300	COG0303	'Molybdopterin
XFF4834R_RS10305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFF4834R_RS10340	COG0708	Exodeoxyribonuclease III
XFF4834R_RS10350	COG0303	'Molybdopterin
XFF4834R_RS10355	COG0746	molybdenum cofactor guanylyltransferase activity
XFF4834R_RS10385	COG1914	H( )-stimulated, divalent metal cation uptake system
XFF4834R_RS10400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFF4834R_RS10405	COG0668	transmembrane transport
XFF4834R_RS10415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XFF4834R_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS10435	COG1183	phosphatidylcholine synthase activity
XFF4834R_RS10445	COG3243	poly(R)-hydroxyalkanoic acid synthase
XFF4834R_RS10460	COG0723	plastoquinol--plastocyanin reductase activity
XFF4834R_RS10460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFF4834R_RS10470	COG2183	response to ionizing radiation
XFF4834R_RS10475	COG2205	protein histidine kinase activity
XFF4834R_RS10475	COG0784	Response regulator, receiver
XFF4834R_RS10545	COG0800	Aldolase
XFF4834R_RS10550	COG0129	dihydroxy-acid dehydratase activity
XFF4834R_RS10555	COG0363	glucosamine-6-phosphate deaminase activity
XFF4834R_RS10560	COG0837	glucose binding
XFF4834R_RS10565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFF4834R_RS10575	COG0354	folic acid binding
XFF4834R_RS10585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFF4834R_RS10600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFF4834R_RS10605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XFF4834R_RS10615	COG4591	ABC-type transport system involved in lipoprotein release permease component
XFF4834R_RS10620	COG1136	(ABC) transporter
XFF4834R_RS10635	COG0811	peptide transport
XFF4834R_RS10640	COG0848	biopolymer transport protein
XFF4834R_RS10645	COG1132	(ABC) transporter
XFF4834R_RS10650	COG1663	tetraacyldisaccharide 4'-kinase activity
XFF4834R_RS10655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFF4834R_RS10660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFF4834R_RS10670	COG0322	excinuclease ABC activity
XFF4834R_RS10675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFF4834R_RS10700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFF4834R_RS10720	COG1054	Belongs to the UPF0176 family
XFF4834R_RS10730	COG1530	ribonuclease E activity
XFF4834R_RS10740	COG3064	Membrane
XFF4834R_RS10745	COG0428	transporter
XFF4834R_RS10755	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFF4834R_RS10760	COG0316	Belongs to the HesB IscA family
XFF4834R_RS10760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFF4834R_RS10805	COG2226	methyltransferase
XFF4834R_RS10805	COG1073	alpha beta
XFF4834R_RS10810	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XFF4834R_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS10890	COG3328	transposase activity
XFF4834R_RS10895	COG3328	transposase activity
XFF4834R_RS10905	COG3220	belongs to the UPF0276 family
XFF4834R_RS10925	COG3920	Histidine kinase
XFF4834R_RS10965	COG3279	Response regulator of the LytR AlgR family
XFF4834R_RS10970	COG3275	phosphorelay sensor kinase activity
XFF4834R_RS11005	COG4566	intracellular signal transduction
XFF4834R_RS11015	COG5001	Diguanylate cyclase
XFF4834R_RS11035	COG3685	Protein conserved in bacteria
XFF4834R_RS11050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XFF4834R_RS11050	COG1648	precorrin-2 dehydrogenase activity
XFF4834R_RS11065	COG2814	Major facilitator Superfamily
XFF4834R_RS11080	COG1335	isochorismatase
XFF4834R_RS11095	COG2197	response regulator
XFF4834R_RS11120	COG0583	DNA-binding transcription factor activity
XFF4834R_RS11125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XFF4834R_RS11135	COG0519	Catalyzes the synthesis of GMP from XMP
XFF4834R_RS11135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFF4834R_RS11145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFF4834R_RS11155	COG0475	glutathione-regulated potassium exporter activity
XFF4834R_RS11155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFF4834R_RS11160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFF4834R_RS11170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFF4834R_RS11175	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFF4834R_RS11185	COG0776	regulation of translation
XFF4834R_RS11190	COG0539	negative regulation of cytoplasmic translation
XFF4834R_RS11195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFF4834R_RS11210	COG2957	Belongs to the agmatine deiminase family
XFF4834R_RS11215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XFF4834R_RS11240	COG0395	ABC-type sugar transport system, permease component
XFF4834R_RS11245	COG1175	transmembrane transport
XFF4834R_RS11275	COG2350	Protein conserved in bacteria
XFF4834R_RS11280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFF4834R_RS11285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XFF4834R_RS11290	COG1187	pseudouridine synthase activity
XFF4834R_RS11310	COG0436	Aminotransferase
XFF4834R_RS11315	COG4133	protoheme IX ABC transporter activity
XFF4834R_RS11335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFF4834R_RS11340	COG1138	Cytochrome C-type biogenesis protein
XFF4834R_RS11360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFF4834R_RS11365	COG1278	Cold shock
XFF4834R_RS11370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XFF4834R_RS11375	COG4988	ABC transporter
XFF4834R_RS11385	COG1294	oxidase, subunit
XFF4834R_RS11415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFF4834R_RS11420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFF4834R_RS11430	COG0165	Argininosuccinate lyase
XFF4834R_RS11435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XFF4834R_RS11445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFF4834R_RS11450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFF4834R_RS11460	COG0137	argininosuccinate synthase activity
XFF4834R_RS11465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFF4834R_RS11475	COG0215	cysteine-tRNA ligase activity
XFF4834R_RS11480	COG2166	iron-sulfur cluster assembly
XFF4834R_RS11500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFF4834R_RS11505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFF4834R_RS11525	COG4302	ethanolamine ammonia-lyase activity
XFF4834R_RS11560	COG3328	transposase activity
XFF4834R_RS11565	COG2963	transposase activity
XFF4834R_RS11580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFF4834R_RS11585	COG0402	S-adenosylhomocysteine deaminase activity
XFF4834R_RS11595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFF4834R_RS11600	COG1509	lysine 2,3-aminomutase activity
XFF4834R_RS11605	COG5001	Diguanylate cyclase
XFF4834R_RS11605	COG3300	MHYT domain
XFF4834R_RS11620	COG0483	inositol monophosphate 1-phosphatase activity
XFF4834R_RS11625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFF4834R_RS11640	COG0488	(ABC) transporter
XFF4834R_RS11645	COG0513	Belongs to the DEAD box helicase family
XFF4834R_RS11650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XFF4834R_RS11655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFF4834R_RS11665	COG0625	glutathione transferase activity
XFF4834R_RS11675	COG4681	YaeQ
XFF4834R_RS11680	COG2081	HI0933 family
XFF4834R_RS11690	COG0501	Belongs to the peptidase M48B family
XFF4834R_RS11695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFF4834R_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS11720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFF4834R_RS11725	COG0860	N-Acetylmuramoyl-L-alanine amidase
XFF4834R_RS11730	COG0802	atpase or kinase
XFF4834R_RS11735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFF4834R_RS11735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFF4834R_RS11740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFF4834R_RS11745	COG1570	exodeoxyribonuclease VII activity
XFF4834R_RS11755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XFF4834R_RS11795	COG0835	chemotaxis
XFF4834R_RS11800	COG0840	transmembrane signaling receptor activity
XFF4834R_RS11805	COG2094	Belongs to the DNA glycosylase MPG family
XFF4834R_RS11810	COG1201	RNA secondary structure unwinding
XFF4834R_RS11825	COG2969	positive regulation of protein catabolic process
XFF4834R_RS11830	COG0625	glutathione transferase activity
XFF4834R_RS11835	COG2857	Cytochrome c1
XFF4834R_RS11840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFF4834R_RS11845	COG0723	plastoquinol--plastocyanin reductase activity
XFF4834R_RS11850	COG0741	lytic transglycosylase activity
XFF4834R_RS11865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFF4834R_RS11870	COG1702	phosphate starvation-inducible protein PhoH
XFF4834R_RS11880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFF4834R_RS11890	COG4535	Mg2 and Co2 transporter CorC
XFF4834R_RS11905	COG1012	belongs to the aldehyde dehydrogenase family
XFF4834R_RS11915	COG1177	transmembrane transport
XFF4834R_RS11920	COG1176	ABC-type spermidine putrescine transport system, permease component I
XFF4834R_RS11945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XFF4834R_RS11960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XFF4834R_RS11965	COG0174	glutamine synthetase
XFF4834R_RS11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFF4834R_RS11980	COG2703	oxygen carrier activity
XFF4834R_RS11985	COG0477	Major facilitator Superfamily
XFF4834R_RS11995	COG0243	molybdopterin cofactor binding
XFF4834R_RS12000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XFF4834R_RS12005	COG2223	nitrite transmembrane transporter activity
XFF4834R_RS12010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XFF4834R_RS12020	COG2733	membrane
XFF4834R_RS12025	COG5002	protein histidine kinase activity
XFF4834R_RS12025	COG2205	protein histidine kinase activity
XFF4834R_RS12025	COG0784	Response regulator, receiver
XFF4834R_RS12035	COG0477	Major facilitator Superfamily
XFF4834R_RS12050	COG3039	Transposase
XFF4834R_RS12055	COG0300	oxidoreductase activity
XFF4834R_RS12065	COG1902	pentaerythritol trinitrate reductase activity
XFF4834R_RS12075	COG3321	synthase
XFF4834R_RS12075	COG0604	alcohol dehydrogenase
XFF4834R_RS12085	COG2902	Dehydrogenase
XFF4834R_RS12095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFF4834R_RS12100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFF4834R_RS12105	COG1609	Transcriptional regulator
XFF4834R_RS12110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFF4834R_RS12110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFF4834R_RS12115	COG1105	Belongs to the carbohydrate kinase PfkB family
XFF4834R_RS12120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XFF4834R_RS12120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XFF4834R_RS12160	COG3328	transposase activity
XFF4834R_RS12180	COG3039	Transposase
XFF4834R_RS12190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFF4834R_RS12200	COG1862	Preprotein translocase
XFF4834R_RS12205	COG0343	queuine tRNA-ribosyltransferase activity
XFF4834R_RS12210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFF4834R_RS12250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XFF4834R_RS12255	COG3291	Pkd domain containing protein
XFF4834R_RS12265	COG0405	Gamma-glutamyltransferase
XFF4834R_RS12270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFF4834R_RS12280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFF4834R_RS12285	COG0742	ribosomal rna small subunit methyltransferase
XFF4834R_RS12290	COG0326	Molecular chaperone. Has ATPase activity
XFF4834R_RS12300	COG3039	Transposase
XFF4834R_RS12360	COG3039	Transposase
XFF4834R_RS12385	COG0531	amino acid
XFF4834R_RS12400	COG0006	proline dipeptidase activity
XFF4834R_RS12410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XFF4834R_RS12425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFF4834R_RS12430	COG3938	Belongs to the proline racemase family
XFF4834R_RS12440	COG0552	protein localization to endoplasmic reticulum
XFF4834R_RS12445	COG1194	a g-specific adenine glycosylase
XFF4834R_RS12450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFF4834R_RS12455	COG4191	Histidine kinase
XFF4834R_RS12455	COG0784	Response regulator, receiver
XFF4834R_RS12470	COG0322	excinuclease ABC activity
XFF4834R_RS12485	COG3039	Transposase
XFF4834R_RS12500	COG3039	Transposase
XFF4834R_RS12510	COG3039	Transposase
XFF4834R_RS12520	COG0582	viral genome integration into host DNA
XFF4834R_RS12530	COG3040	lipid binding
XFF4834R_RS12540	COG1960	acyl-CoA dehydrogenase activity
XFF4834R_RS12550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFF4834R_RS12570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFF4834R_RS12575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFF4834R_RS12580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFF4834R_RS12605	COG0438	transferase activity, transferring glycosyl groups
XFF4834R_RS12615	COG0438	transferase activity, transferring glycosyl groups
XFF4834R_RS12620	COG0438	transferase activity, transferring glycosyl groups
XFF4834R_RS12670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFF4834R_RS12670	COG0072	phenylalanine-tRNA ligase activity
XFF4834R_RS12675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFF4834R_RS12690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFF4834R_RS12695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFF4834R_RS12710	COG2211	Major facilitator Superfamily
XFF4834R_RS12710	COG2190	(PTS) system
XFF4834R_RS12720	COG1082	Xylose isomerase domain protein TIM barrel
XFF4834R_RS12725	COG3328	transposase activity
XFF4834R_RS12800	COG2948	multi-organism process
XFF4834R_RS12820	COG3505	Type IV secretory pathway VirD4
XFF4834R_RS12835	COG0556	nucleotide-excision repair
XFF4834R_RS12840	COG3328	transposase activity
XFF4834R_RS12880	COG1611	Belongs to the LOG family
XFF4834R_RS12890	COG2095	MarC family integral membrane protein
XFF4834R_RS12900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFF4834R_RS12935	COG1185	polyribonucleotide nucleotidyltransferase activity
XFF4834R_RS12940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XFF4834R_RS12945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XFF4834R_RS12950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFF4834R_RS12955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFF4834R_RS12960	COG0195	Participates in both transcription termination and antitermination
XFF4834R_RS12965	COG0779	Required for maturation of 30S ribosomal subunits
XFF4834R_RS12975	COG1007	ATP synthesis coupled electron transport
XFF4834R_RS13000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFF4834R_RS13005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XFF4834R_RS13015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFF4834R_RS13020	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFF4834R_RS13025	COG0649	NAD binding
XFF4834R_RS13030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFF4834R_RS13035	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFF4834R_RS13040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFF4834R_RS13055	COG0149	triose-phosphate isomerase activity
XFF4834R_RS13060	COG0300	oxidoreductase activity
XFF4834R_RS13095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFF4834R_RS13100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XFF4834R_RS13105	COG0159	tryptophan synthase activity
XFF4834R_RS13115	COG0133	tryptophan synthase activity
XFF4834R_RS13125	COG0135	phosphoribosylanthranilate isomerase activity
XFF4834R_RS13130	COG0101	tRNA pseudouridine synthase activity
XFF4834R_RS13155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFF4834R_RS13160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XFF4834R_RS13165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFF4834R_RS13170	COG2890	protein-(glutamine-N5) methyltransferase activity
XFF4834R_RS13180	COG0688	phosphatidylethanolamine metabolic process
XFF4834R_RS13190	COG0433	COG0433 Predicted ATPase
XFF4834R_RS13195	COG0494	nUDIX hydrolase
XFF4834R_RS13210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFF4834R_RS13215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFF4834R_RS13220	COG3328	transposase activity
XFF4834R_RS13225	COG3328	transposase activity
XFF4834R_RS13235	COG0477	Major facilitator Superfamily
XFF4834R_RS13240	COG2115	Belongs to the xylose isomerase family
XFF4834R_RS13245	COG1070	Carbohydrate kinase
XFF4834R_RS13255	COG1501	Belongs to the glycosyl hydrolase 31 family
XFF4834R_RS13295	COG0800	Aldolase
XFF4834R_RS13300	COG4948	Mandelate Racemase Muconate Lactonizing
XFF4834R_RS13310	COG3734	2-keto-3-deoxy-galactonokinase
XFF4834R_RS13315	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFF4834R_RS13325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XFF4834R_RS13340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFF4834R_RS13345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XFF4834R_RS13360	COG0351	phosphomethylpyrimidine kinase
XFF4834R_RS13385	COG0583	DNA-binding transcription factor activity
XFF4834R_RS13395	COG1741	Belongs to the pirin family
XFF4834R_RS13410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XFF4834R_RS13415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XFF4834R_RS13420	COG2137	regulation of response to DNA damage stimulus
XFF4834R_RS13425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFF4834R_RS13430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFF4834R_RS13440	COG1546	Belongs to the CinA family
XFF4834R_RS13445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFF4834R_RS13455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFF4834R_RS13460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFF4834R_RS13470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XFF4834R_RS13475	COG1534	Rna-binding protein
XFF4834R_RS13490	COG1238	metal cluster binding
XFF4834R_RS13495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFF4834R_RS13500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFF4834R_RS13505	COG2840	Smr protein MutS2
XFF4834R_RS13510	COG0585	pseudouridine synthase activity
XFF4834R_RS13515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFF4834R_RS13520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFF4834R_RS13525	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFF4834R_RS13530	COG0148	phosphopyruvate hydratase activity
XFF4834R_RS13545	COG0504	CTP synthase activity
XFF4834R_RS13570	COG0306	phosphate transporter
XFF4834R_RS13580	COG1253	flavin adenine dinucleotide binding
XFF4834R_RS13595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFF4834R_RS13605	COG2271	Major facilitator Superfamily
XFF4834R_RS13615	COG1136	(ABC) transporter
XFF4834R_RS13640	COG2264	protein methyltransferase activity
XFF4834R_RS13670	COG2244	polysaccharide biosynthetic process
XFF4834R_RS13720	COG1595	DNA-templated transcription, initiation
XFF4834R_RS13735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XFF4834R_RS13745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFF4834R_RS13755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFF4834R_RS13770	COG0784	Response regulator, receiver
XFF4834R_RS13770	COG4191	Histidine kinase
XFF4834R_RS13775	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XFF4834R_RS13810	COG0840	transmembrane signaling receptor activity
XFF4834R_RS13820	COG3039	Transposase
XFF4834R_RS13835	COG0583	DNA-binding transcription factor activity
XFF4834R_RS13840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XFF4834R_RS13845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFF4834R_RS13860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFF4834R_RS13865	COG1605	Chorismate mutase
XFF4834R_RS13865	COG0077	Prephenate dehydratase
XFF4834R_RS13870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XFF4834R_RS13875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XFF4834R_RS13880	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XFF4834R_RS13920	COG1228	amidohydrolase
XFF4834R_RS13925	COG2986	histidine ammonia-lyase
XFF4834R_RS13935	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XFF4834R_RS13945	COG4993	Dehydrogenase
XFF4834R_RS13955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XFF4834R_RS13965	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFF4834R_RS13970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFF4834R_RS13975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XFF4834R_RS13985	COG3115	cell septum assembly
XFF4834R_RS14000	COG0359	binds to the 23S rRNA
XFF4834R_RS14005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFF4834R_RS14010	COG0360	Binds together with S18 to 16S ribosomal RNA
XFF4834R_RS14015	COG0316	Belongs to the HesB IscA family
XFF4834R_RS14020	COG0017	Asparaginyl-tRNA synthetase
XFF4834R_RS14055	COG3328	transposase activity
XFF4834R_RS14060	COG3039	Transposase
XFF4834R_RS14110	COG0288	reversible hydration of carbon dioxide
XFF4834R_RS14115	COG0662	Cupin 2, conserved barrel domain protein
XFF4834R_RS14125	COG3844	kynureninase activity
XFF4834R_RS14130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFF4834R_RS14135	COG2925	Exonuclease
XFF4834R_RS14155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XFF4834R_RS14160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFF4834R_RS14160	COG0116	Belongs to the methyltransferase superfamily
XFF4834R_RS14165	COG0488	(ABC) transporter
XFF4834R_RS14200	COG0494	nUDIX hydrolase
XFF4834R_RS14210	COG1024	Enoyl-CoA hydratase
XFF4834R_RS14220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFF4834R_RS14225	COG0659	secondary active sulfate transmembrane transporter activity
XFF4834R_RS14250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFF4834R_RS14255	COG0573	inorganic phosphate transmembrane transporter activity
XFF4834R_RS14260	COG0581	inorganic phosphate transmembrane transporter activity
XFF4834R_RS14265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFF4834R_RS14270	COG0704	Plays a role in the regulation of phosphate uptake
XFF4834R_RS14280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFF4834R_RS14290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFF4834R_RS14300	COG0557	exoribonuclease II activity
XFF4834R_RS14315	COG1960	acyl-CoA dehydrogenase activity
XFF4834R_RS14320	COG3328	transposase activity
XFF4834R_RS14325	COG1960	acyl-CoA dehydrogenase activity
XFF4834R_RS14330	COG2226	methyltransferase
XFF4834R_RS14335	COG0646	methionine synthase
XFF4834R_RS14335	COG1410	methionine synthase
XFF4834R_RS14340	COG1410	methionine synthase
XFF4834R_RS14340	COG0646	methionine synthase
XFF4834R_RS14350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFF4834R_RS14375	COG2900	Belongs to the SlyX family
XFF4834R_RS14390	COG0386	Belongs to the glutathione peroxidase family
XFF4834R_RS14400	COG1725	Transcriptional regulator
XFF4834R_RS14405	COG1131	(ABC) transporter
XFF4834R_RS14435	COG1253	flavin adenine dinucleotide binding
XFF4834R_RS14460	COG2850	peptidyl-arginine hydroxylation
XFF4834R_RS14470	COG0567	Dehydrogenase, E1 component
XFF4834R_RS14495	COG1132	(ABC) transporter
XFF4834R_RS14500	COG0583	DNA-binding transcription factor activity
XFF4834R_RS14530	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XFF4834R_RS14535	COG0484	heat shock protein binding
XFF4834R_RS14540	COG0443	Heat shock 70 kDa protein
XFF4834R_RS14545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFF4834R_RS14550	COG1420	regulation of RNA biosynthetic process
XFF4834R_RS14555	COG0497	DNA recombination
XFF4834R_RS14565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFF4834R_RS14580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XFF4834R_RS14595	COG3328	transposase activity
XFF4834R_RS14610	COG3706	GGDEF domain
XFF4834R_RS14655	COG0583	DNA-binding transcription factor activity
XFF4834R_RS14665	COG0415	Belongs to the DNA photolyase family
XFF4834R_RS14670	COG0305	Participates in initiation and elongation during chromosome replication
XFF4834R_RS14680	COG0367	asparagine synthase
XFF4834R_RS14695	COG1960	acyl-CoA dehydrogenase activity
XFF4834R_RS14710	COG0084	hydrolase, TatD family'
XFF4834R_RS14715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFF4834R_RS14770	COG0386	Belongs to the glutathione peroxidase family
XFF4834R_RS14775	COG0339	signal peptide processing
XFF4834R_RS14825	COG2814	Major facilitator Superfamily
XFF4834R_RS14830	COG1566	PFAM secretion protein HlyD family protein
XFF4834R_RS14855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFF4834R_RS14870	COG4774	siderophore transport
XFF4834R_RS14880	COG0367	asparagine synthase
XFF4834R_RS14885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFF4834R_RS14890	COG1393	Belongs to the ArsC family
XFF4834R_RS14900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XFF4834R_RS14940	COG0052	Belongs to the universal ribosomal protein uS2 family
XFF4834R_RS14945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFF4834R_RS14955	COG0528	UMP kinase activity
XFF4834R_RS14960	COG0233	cytoplasmic translational termination
XFF4834R_RS14965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFF4834R_RS14970	COG0575	Belongs to the CDS family
XFF4834R_RS14975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XFF4834R_RS14980	COG0750	zinc metalloprotease
XFF4834R_RS14995	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFF4834R_RS15000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFF4834R_RS15005	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFF4834R_RS15010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFF4834R_RS15025	COG0825	malonyl-CoA metabolic process
XFF4834R_RS15040	COG1981	membrane
XFF4834R_RS15060	COG1695	Transcriptional regulator
XFF4834R_RS15080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XFF4834R_RS15090	COG2040	homocysteine
XFF4834R_RS15095	COG0833	amino acid
XFF4834R_RS15100	COG0346	lactoylglutathione lyase activity
XFF4834R_RS15105	COG1131	(ABC) transporter
XFF4834R_RS15115	COG3039	Transposase
XFF4834R_RS15130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFF4834R_RS15130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFF4834R_RS15140	COG2878	Part of a membrane complex involved in electron transport
XFF4834R_RS15160	COG1595	DNA-templated transcription, initiation
XFF4834R_RS15185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XFF4834R_RS15200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XFF4834R_RS15205	COG0251	oxidation-reduction process
XFF4834R_RS15215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFF4834R_RS15215	COG0392	lysyltransferase activity
XFF4834R_RS15250	COG2814	Major facilitator Superfamily
XFF4834R_RS15255	COG1902	pentaerythritol trinitrate reductase activity
XFF4834R_RS15260	COG2824	Alkylphosphonate utilization operon protein PhnA
XFF4834R_RS15270	COG1047	Peptidyl-prolyl cis-trans
XFF4834R_RS15275	COG1077	Cell shape determining protein MreB Mrl
XFF4834R_RS15290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XFF4834R_RS15300	COG5487	UPF0391 membrane protein
XFF4834R_RS15305	COG1451	nucleotide metabolic process
XFF4834R_RS15320	COG0183	Belongs to the thiolase family
XFF4834R_RS15350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XFF4834R_RS15350	COG1793	dna ligase
XFF4834R_RS15360	COG1793	dna ligase
XFF4834R_RS15365	COG1201	RNA secondary structure unwinding
XFF4834R_RS15375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFF4834R_RS15380	COG1278	Cold shock
XFF4834R_RS15385	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XFF4834R_RS15390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XFF4834R_RS15395	COG1472	Belongs to the glycosyl hydrolase 3 family
XFF4834R_RS15400	COG3046	protein related to deoxyribodipyrimidine photolyase
XFF4834R_RS15405	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XFF4834R_RS15410	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFF4834R_RS15415	COG2954	triphosphatase activity
XFF4834R_RS15420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFF4834R_RS15430	COG1381	Involved in DNA repair and RecF pathway recombination
XFF4834R_RS15435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFF4834R_RS15440	COG0571	ribonuclease III activity
XFF4834R_RS15455	COG0481	GTPase activity
XFF4834R_RS15460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFF4834R_RS15475	COG1250	3-hydroxyacyl-CoA dehydrogenase
XFF4834R_RS15475	COG1024	Enoyl-CoA hydratase
XFF4834R_RS15490	COG3039	Transposase
XFF4834R_RS15515	COG1024	Enoyl-CoA hydratase
XFF4834R_RS15520	COG1960	acyl-CoA dehydrogenase activity
XFF4834R_RS15540	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XFF4834R_RS15545	COG3250	beta-galactosidase activity
XFF4834R_RS15565	COG3328	transposase activity
XFF4834R_RS15570	COG3039	Transposase
XFF4834R_RS15655	COG3328	transposase activity
XFF4834R_RS15695	COG3328	transposase activity
XFF4834R_RS15705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFF4834R_RS15715	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFF4834R_RS15740	COG0534	Mate efflux family protein
XFF4834R_RS15745	COG0335	large ribosomal subunit rRNA binding
XFF4834R_RS15750	COG0336	Belongs to the RNA methyltransferase TrmD family
XFF4834R_RS15755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFF4834R_RS15760	COG0228	four-way junction DNA binding
XFF4834R_RS15780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFF4834R_RS15785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XFF4834R_RS15815	COG0784	Response regulator, receiver
XFF4834R_RS15815	COG4191	Histidine kinase
XFF4834R_RS15820	COG2205	protein histidine kinase activity
XFF4834R_RS15820	COG4999	Histidine kinase
XFF4834R_RS15820	COG3850	Histidine kinase
XFF4834R_RS15820	COG3437	response regulator, receiver
XFF4834R_RS15825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XFF4834R_RS15835	COG2205	protein histidine kinase activity
XFF4834R_RS15840	COG5507	3-demethylubiquinone-9 3-methyltransferase
XFF4834R_RS15850	COG4771	TonB-dependent receptor
XFF4834R_RS15875	COG2172	sigma factor antagonist activity
XFF4834R_RS15880	COG1366	Belongs to the anti-sigma-factor antagonist family
XFF4834R_RS15885	COG1366	Belongs to the anti-sigma-factor antagonist family
XFF4834R_RS15895	COG0326	Molecular chaperone. Has ATPase activity
XFF4834R_RS15900	COG2207	Transcriptional regulator
XFF4834R_RS15910	COG3152	Membrane
XFF4834R_RS15925	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFF4834R_RS15930	COG1845	cytochrome c oxidase, subunit III
XFF4834R_RS15935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFF4834R_RS15970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XFF4834R_RS15975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XFF4834R_RS15980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XFF4834R_RS15985	COG0196	riboflavin kinase activity
XFF4834R_RS15995	COG0268	Binds directly to 16S ribosomal RNA
XFF4834R_RS16000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFF4834R_RS16005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFF4834R_RS16010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFF4834R_RS16015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XFF4834R_RS16020	COG0824	Thioesterase
XFF4834R_RS16035	COG1946	Acyl-CoA thioesterase
XFF4834R_RS16055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFF4834R_RS16065	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XFF4834R_RS16090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFF4834R_RS16105	COG2197	response regulator
XFF4834R_RS16110	COG4585	Histidine kinase
XFF4834R_RS16120	COG0850	regulation of cytokinetic process
XFF4834R_RS16125	COG2894	cell division
XFF4834R_RS16130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XFF4834R_RS16140	COG0642	Histidine kinase
XFF4834R_RS16145	COG0745	RESPONSE REGULATOR receiver
XFF4834R_RS16160	COG2194	sulfuric ester hydrolase activity
XFF4834R_RS16175	COG2814	Major facilitator Superfamily
XFF4834R_RS16180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFF4834R_RS16180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFF4834R_RS16190	COG0656	L-ascorbic acid biosynthetic process
XFF4834R_RS16195	COG0753	catalase activity
XFF4834R_RS16215	COG2207	Transcriptional regulator
XFF4834R_RS16215	COG1917	Cupin 2, conserved barrel domain protein
XFF4834R_RS16230	COG1506	peptidase
XFF4834R_RS16230	COG0823	Involved in the tonB-independent uptake of proteins
XFF4834R_RS16245	COG1297	OPT oligopeptide transporter protein
XFF4834R_RS16260	COG0587	DNA-directed DNA polymerase activity
XFF4834R_RS16280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFF4834R_RS16315	COG2080	2 iron, 2 sulfur cluster binding
XFF4834R_RS16320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XFF4834R_RS16325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XFF4834R_RS16355	COG0492	ferredoxin-NADP+ reductase activity
XFF4834R_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS16375	COG3537	Alpha-1,2-mannosidase
XFF4834R_RS16380	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS16385	COG3387	PFAM Glycoside hydrolase 15-related
XFF4834R_RS16395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFF4834R_RS16425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFF4834R_RS16430	COG3328	transposase activity
XFF4834R_RS16465	COG1309	transcriptional regulator
XFF4834R_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS16485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFF4834R_RS16495	COG0330	HflC and HflK could
XFF4834R_RS16500	COG0330	HflC and HflK could
XFF4834R_RS16520	COG0678	peroxiredoxin activity
XFF4834R_RS16530	COG4953	penicillin-binding protein 1C
XFF4834R_RS16545	COG2373	Large extracellular alpha-helical protein
XFF4834R_RS16550	COG3039	Transposase
XFF4834R_RS16555	COG1307	EDD domain protein, DegV family
XFF4834R_RS16560	COG0242	peptide deformylase activity
XFF4834R_RS16585	COG0457	Tetratricopeptide repeat
XFF4834R_RS16590	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XFF4834R_RS16595	COG1215	transferase activity, transferring glycosyl groups
XFF4834R_RS16600	COG1215	transferase activity, transferring glycosyl groups
XFF4834R_RS16615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFF4834R_RS16665	COG2188	Transcriptional regulator
XFF4834R_RS16675	COG1450	Type ii and iii secretion system protein
XFF4834R_RS16690	COG3166	PFAM Fimbrial assembly family protein
XFF4834R_RS16695	COG3156	type II secretion system protein K
XFF4834R_RS16700	COG4795	General secretion pathway protein
XFF4834R_RS16705	COG2165	general secretion pathway protein
XFF4834R_RS16710	COG4970	Tfp pilus assembly protein FimT
XFF4834R_RS16715	COG2165	general secretion pathway protein
XFF4834R_RS16720	COG1459	type II secretion system
XFF4834R_RS16725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFF4834R_RS16730	COG1404	Belongs to the peptidase S8 family
XFF4834R_RS16735	COG5295	Hep Hag repeat protein
XFF4834R_RS16740	COG1404	Belongs to the peptidase S8 family
XFF4834R_RS16745	COG5295	Hep Hag repeat protein
XFF4834R_RS16755	COG0047	phosphoribosylformylglycinamidine synthase activity
XFF4834R_RS16755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XFF4834R_RS16760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFF4834R_RS16765	COG4974	Belongs to the 'phage' integrase family
XFF4834R_RS16780	COG0795	lipopolysaccharide-transporting ATPase activity
XFF4834R_RS16790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFF4834R_RS16805	COG0525	valine-tRNA ligase activity
XFF4834R_RS16840	COG1183	phosphatidylcholine synthase activity
XFF4834R_RS16850	COG0442	prolyl-tRNA aminoacylation
XFF4834R_RS16865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFF4834R_RS16870	COG1127	ABC transporter
XFF4834R_RS16875	COG3218	ABC-type transport auxiliary lipoprotein component
XFF4834R_RS16875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFF4834R_RS16905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFF4834R_RS16910	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XFF4834R_RS16910	COG0662	Cupin 2, conserved barrel domain protein
XFF4834R_RS16940	COG2086	electron transfer activity
XFF4834R_RS16950	COG0463	Glycosyl transferase, family 2
XFF4834R_RS16980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFF4834R_RS16985	COG0438	transferase activity, transferring glycosyl groups
XFF4834R_RS17005	COG0438	transferase activity, transferring glycosyl groups
XFF4834R_RS17010	COG0626	cystathionine gamma-synthase activity
XFF4834R_RS17040	COG0625	glutathione transferase activity
XFF4834R_RS17050	COG0513	Belongs to the DEAD box helicase family
XFF4834R_RS17060	COG4771	TonB-dependent receptor
XFF4834R_RS17065	COG3328	transposase activity
XFF4834R_RS17070	COG0720	synthase
XFF4834R_RS17090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFF4834R_RS17100	COG1956	GAF domain-containing protein
XFF4834R_RS17110	COG2819	hydrolase of the alpha beta superfamily
XFF4834R_RS17120	COG0546	phosphoglycolate phosphatase activity
XFF4834R_RS17125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XFF4834R_RS17130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFF4834R_RS17145	COG0339	signal peptide processing
XFF4834R_RS17195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFF4834R_RS17200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFF4834R_RS17205	COG1136	(ABC) transporter
XFF4834R_RS17210	COG0577	efflux transmembrane transporter activity
XFF4834R_RS17215	COG1136	(ABC) transporter
XFF4834R_RS17215	COG0577	efflux transmembrane transporter activity
XFF4834R_RS17230	COG4191	Histidine kinase
XFF4834R_RS17235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFF4834R_RS17255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFF4834R_RS17260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFF4834R_RS17265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFF4834R_RS17270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFF4834R_RS17275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFF4834R_RS17280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFF4834R_RS17290	COG0356	it plays a direct role in the translocation of protons across the membrane
XFF4834R_RS17310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XFF4834R_RS17320	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFF4834R_RS17360	COG2011	ABC-type metal ion transport system permease component
XFF4834R_RS17365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFF4834R_RS17370	COG0697	spore germination
XFF4834R_RS17375	COG1666	GTP binding
XFF4834R_RS17385	COG0784	Response regulator, receiver
XFF4834R_RS17385	COG2198	Histidine kinase
XFF4834R_RS17385	COG5002	protein histidine kinase activity
XFF4834R_RS17420	COG1187	pseudouridine synthase activity
XFF4834R_RS17445	COG2202	Pas domain
XFF4834R_RS17445	COG2205	protein histidine kinase activity
XFF4834R_RS17465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFF4834R_RS17470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFF4834R_RS17525	COG0842	Transport permease protein
XFF4834R_RS17530	COG1131	(ABC) transporter
XFF4834R_RS17535	COG0025	NhaP-type Na H and K H
XFF4834R_RS17540	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XFF4834R_RS17545	COG1573	uracil-dna glycosylase
XFF4834R_RS17555	COG3384	dioxygenase
XFF4834R_RS17565	COG0583	DNA-binding transcription factor activity
XFF4834R_RS17575	COG0667	Aldo Keto reductase
XFF4834R_RS17585	COG3590	peptidase
XFF4834R_RS17600	COG0531	amino acid
XFF4834R_RS17615	COG2972	Histidine kinase
XFF4834R_RS17630	COG3685	Protein conserved in bacteria
XFF4834R_RS17635	COG3546	catalase activity
XFF4834R_RS17670	COG2204	response regulator
XFF4834R_RS17680	COG1271	oxidase subunit
XFF4834R_RS17685	COG1294	oxidase, subunit
XFF4834R_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS17705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XFF4834R_RS17725	COG1132	(ABC) transporter
XFF4834R_RS17740	COG1063	alcohol dehydrogenase
XFF4834R_RS17815	COG0251	oxidation-reduction process
XFF4834R_RS17845	COG0583	DNA-binding transcription factor activity
XFF4834R_RS17850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XFF4834R_RS17880	COG0659	secondary active sulfate transmembrane transporter activity
XFF4834R_RS17890	COG0024	Methionine aminopeptidase
XFF4834R_RS17930	COG3328	transposase activity
XFF4834R_RS17940	COG0582	viral genome integration into host DNA
XFF4834R_RS17955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFF4834R_RS17960	COG1490	D-aminoacyl-tRNA deacylase activity
XFF4834R_RS17965	COG1560	Kdo2-lipid A biosynthetic process
XFF4834R_RS18015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XFF4834R_RS18015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFF4834R_RS18020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XFF4834R_RS18025	COG0242	peptide deformylase activity
XFF4834R_RS18030	COG1652	LysM domain
XFF4834R_RS18035	COG0758	DNA mediated transformation
XFF4834R_RS18055	COG1754	DNA topoisomerase type I activity
XFF4834R_RS18055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFF4834R_RS18060	COG0009	L-threonylcarbamoyladenylate synthase
XFF4834R_RS18075	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS18090	COG0616	signal peptide processing
XFF4834R_RS18095	COG0534	Mate efflux family protein
XFF4834R_RS18115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFF4834R_RS18120	COG0625	glutathione transferase activity
XFF4834R_RS18135	COG1252	NADH dehydrogenase
XFF4834R_RS18140	COG2860	membrane
XFF4834R_RS18145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFF4834R_RS18150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFF4834R_RS18155	COG2201	protein-glutamate methylesterase activity
XFF4834R_RS18160	COG2177	Part of the ABC transporter FtsEX involved in
XFF4834R_RS18165	COG2884	Cell division ATP-binding protein ftsE
XFF4834R_RS18170	COG0513	Belongs to the DEAD box helicase family
XFF4834R_RS18175	COG3118	belongs to the thioredoxin family
XFF4834R_RS18180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFF4834R_RS18185	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XFF4834R_RS18190	COG3328	transposase activity
XFF4834R_RS18195	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XFF4834R_RS18200	COG0583	DNA-binding transcription factor activity
XFF4834R_RS18220	COG1652	LysM domain
XFF4834R_RS18225	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFF4834R_RS18225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFF4834R_RS18230	COG1473	amidohydrolase
XFF4834R_RS18235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFF4834R_RS18240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFF4834R_RS18260	COG5383	Protein conserved in bacteria
XFF4834R_RS18305	COG3023	N-Acetylmuramoyl-L-alanine amidase
XFF4834R_RS18315	COG4948	Mandelate Racemase Muconate Lactonizing
XFF4834R_RS18325	COG0531	amino acid
XFF4834R_RS18340	COG4682	membrane
XFF4834R_RS18345	COG2133	pyrroloquinoline quinone binding
XFF4834R_RS18355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFF4834R_RS18360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFF4834R_RS18370	COG1610	YqeY-like protein
XFF4834R_RS18375	COG1295	ribonuclease BN
XFF4834R_RS18380	COG0358	DNA primase activity
XFF4834R_RS18395	COG0109	protoheme IX farnesyltransferase activity
XFF4834R_RS18425	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XFF4834R_RS18440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFF4834R_RS18485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFF4834R_RS18490	COG0739	heme binding
XFF4834R_RS18495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XFF4834R_RS18505	COG2223	nitrite transmembrane transporter activity
XFF4834R_RS18510	COG0708	Exodeoxyribonuclease III
XFF4834R_RS18515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFF4834R_RS18525	COG1192	Involved in chromosome partitioning
XFF4834R_RS18530	COG1475	DNA binding
XFF4834R_RS18550	COG0463	Glycosyl transferase, family 2
XFF4834R_RS18570	COG0756	dUTP diphosphatase activity
XFF4834R_RS18575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFF4834R_RS18580	COG2003	Belongs to the UPF0758 family
XFF4834R_RS18585	COG0018	arginyl-trna synthetase
XFF4834R_RS18600	COG4221	oxidoreductase activity
XFF4834R_RS18605	COG2755	lipolytic protein G-D-S-L family
XFF4834R_RS18605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFF4834R_RS18625	COG3039	Transposase
XFF4834R_RS18630	COG1166	arginine decarboxylase activity
XFF4834R_RS18635	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFF4834R_RS18660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFF4834R_RS18660	COG3291	Pkd domain containing protein
XFF4834R_RS18675	COG0606	chelatase, subunit chli
XFF4834R_RS18690	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFF4834R_RS18725	COG1690	Belongs to the RtcB family
XFF4834R_RS18765	COG1090	epimerase
XFF4834R_RS18775	COG0642	Histidine kinase
XFF4834R_RS18795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFF4834R_RS18820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XFF4834R_RS18825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFF4834R_RS18830	COG3328	transposase activity
XFF4834R_RS18840	COG2197	response regulator
XFF4834R_RS18845	COG4585	Histidine kinase
XFF4834R_RS18850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFF4834R_RS18855	COG3328	transposase activity
XFF4834R_RS18860	COG1136	(ABC) transporter
XFF4834R_RS18885	COG0697	spore germination
XFF4834R_RS18905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFF4834R_RS18910	COG0180	Tryptophanyl-tRNA synthetase
XFF4834R_RS18915	COG3237	CsbD-like
XFF4834R_RS18955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XFF4834R_RS18970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFF4834R_RS19015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XFF4834R_RS19035	COG1199	ATP-dependent helicase activity
XFF4834R_RS19050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFF4834R_RS19110	COG0625	glutathione transferase activity
XFF4834R_RS19150	COG4555	ABC transporter
XFF4834R_RS19160	COG1476	TRANSCRIPTIONal
XFF4834R_RS19180	COG1230	cation diffusion facilitator family transporter
XFF4834R_RS19190	COG4774	siderophore transport
XFF4834R_RS19205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XFF4834R_RS19210	COG1131	(ABC) transporter
XFF4834R_RS19215	COG0842	Transport permease protein
XFF4834R_RS19220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XFF4834R_RS19250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFF4834R_RS19255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFF4834R_RS19270	COG2239	Acts as a magnesium transporter
XFF4834R_RS19285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFF4834R_RS19290	COG3387	PFAM Glycoside hydrolase 15-related
XFF4834R_RS19305	COG3100	YcgL domain-containing protein
XFF4834R_RS19310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFF4834R_RS19320	COG0463	Glycosyl transferase, family 2
XFF4834R_RS19330	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS19365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFF4834R_RS19380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XFF4834R_RS19405	COG4946	Tricorn protease homolog
XFF4834R_RS19405	COG1506	peptidase
XFF4834R_RS19405	COG0823	Involved in the tonB-independent uptake of proteins
XFF4834R_RS19425	COG0408	coproporphyrinogen oxidase activity
XFF4834R_RS19460	COG0515	serine threonine protein kinase
XFF4834R_RS19525	COG1595	DNA-templated transcription, initiation
XFF4834R_RS19565	COG3328	transposase activity
XFF4834R_RS19635	COG0210	DNA helicase
XFF4834R_RS19645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFF4834R_RS19650	COG0583	DNA-binding transcription factor activity
XFF4834R_RS19655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XFF4834R_RS19685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFF4834R_RS19705	COG0357	Ribosomal RNA small subunit methyltransferase G
XFF4834R_RS19710	COG3540	Alkaline phosphatase
XFF4834R_RS19720	COG2091	lysine biosynthetic process via aminoadipic acid
XFF4834R_RS19740	COG0708	Exodeoxyribonuclease III
XFF4834R_RS19745	COG1940	carbohydrate kinase activity
XFF4834R_RS19745	COG1846	Transcriptional regulator
XFF4834R_RS19755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFF4834R_RS19765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XFF4834R_RS19770	COG3162	membrane
XFF4834R_RS19780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFF4834R_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS19835	COG0179	Fumarylacetoacetate (FAA) hydrolase
XFF4834R_RS19840	COG4948	Mandelate Racemase Muconate Lactonizing
XFF4834R_RS19845	COG3254	rhamnose metabolic process
XFF4834R_RS19850	COG0738	Major facilitator superfamily
XFF4834R_RS19855	COG1414	Transcriptional regulator
XFF4834R_RS19860	COG1971	Probably functions as a manganese efflux pump
XFF4834R_RS19865	COG2205	protein histidine kinase activity
XFF4834R_RS19875	COG3459	Glycosyltransferase 36 associated
XFF4834R_RS19880	COG2211	Major facilitator Superfamily
XFF4834R_RS19885	COG3265	gluconokinase activity
XFF4834R_RS19890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFF4834R_RS19910	COG2911	Protein conserved in bacteria
XFF4834R_RS19915	COG0729	surface antigen
XFF4834R_RS19950	COG0752	glycyl-tRNA synthetase alpha subunit
XFF4834R_RS19955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFF4834R_RS19970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFF4834R_RS19970	COG0519	Catalyzes the synthesis of GMP from XMP
XFF4834R_RS19980	COG0805	protein transport
XFF4834R_RS19985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFF4834R_RS19990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFF4834R_RS20000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFF4834R_RS20020	COG2974	May be involved in recombination
XFF4834R_RS20025	COG0037	tRNA processing
XFF4834R_RS20030	COG2115	Belongs to the xylose isomerase family
XFF4834R_RS20050	COG4948	Mandelate Racemase Muconate Lactonizing
XFF4834R_RS20060	COG1472	Belongs to the glycosyl hydrolase 3 family
XFF4834R_RS20065	COG0246	Mannitol dehydrogenase
XFF4834R_RS20135	COG3386	PFAM SMP-30 Gluconolaconase
XFF4834R_RS20145	COG3250	beta-galactosidase activity
XFF4834R_RS20150	COG1904	glucuronate isomerase
XFF4834R_RS20170	COG3693	PFAM glycoside hydrolase, family 10
XFF4834R_RS20185	COG2211	Major facilitator Superfamily
XFF4834R_RS20215	COG2937	Belongs to the GPAT DAPAT family
XFF4834R_RS20250	COG0284	orotidine-5'-phosphate decarboxylase activity
XFF4834R_RS20255	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XFF4834R_RS20260	COG3132	Protein of unknown function, DUF480
XFF4834R_RS20275	COG0210	DNA helicase
XFF4834R_RS20280	COG1435	thymidine kinase activity
XFF4834R_RS20290	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XFF4834R_RS20300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFF4834R_RS20330	COG3135	benzoate transporter
XFF4834R_RS20350	COG0676	glucose-6-phosphate 1-epimerase activity
XFF4834R_RS20360	COG3012	SEC-C Motif Domain Protein
XFF4834R_RS20365	COG0730	response to heat
XFF4834R_RS20385	COG0302	gtp cyclohydrolase
XFF4834R_RS20400	COG1566	PFAM secretion protein HlyD family protein
XFF4834R_RS20410	COG1289	transmembrane transporter activity
XFF4834R_RS20415	COG0477	Major facilitator Superfamily
XFF4834R_RS20425	COG0583	DNA-binding transcription factor activity
XFF4834R_RS20430	COG4221	oxidoreductase activity
XFF4834R_RS20440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFF4834R_RS20460	COG3328	transposase activity
XFF4834R_RS20485	COG0564	pseudouridine synthase activity
XFF4834R_RS20500	COG3039	Transposase
XFF4834R_RS20505	COG3039	Transposase
XFF4834R_RS20515	COG3039	Transposase
XFF4834R_RS20540	COG1028	Short-chain dehydrogenase reductase Sdr
XFF4834R_RS20570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFF4834R_RS20575	COG1074	ATP-dependent DNA helicase activity
XFF4834R_RS20580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XFF4834R_RS20615	COG1127	ABC transporter
XFF4834R_RS20620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFF4834R_RS20625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFF4834R_RS20640	COG2853	Lipoprotein
XFF4834R_RS20650	COG0386	Belongs to the glutathione peroxidase family
XFF4834R_RS20675	COG0625	glutathione transferase activity
XFF4834R_RS20725	COG3077	Addiction module antitoxin, RelB DinJ family
XFF4834R_RS20730	COG3041	Addiction module toxin RelE StbE family
XFF4834R_RS20790	COG0840	transmembrane signaling receptor activity
XFF4834R_RS20815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFF4834R_RS20820	COG4691	Plasmid stability protein
XFF4834R_RS20835	COG3328	transposase activity
XFF4834R_RS20840	COG3328	transposase activity
XFF4834R_RS20845	COG3039	Transposase
XFF4834R_RS20855	COG1192	Involved in chromosome partitioning
XFF4834R_RS20880	COG3537	Alpha-1,2-mannosidase
XFF4834R_RS20895	COG3835	regulator
XFF4834R_RS20900	COG1929	Belongs to the glycerate kinase type-1 family
XFF4834R_RS20905	COG2271	Major facilitator Superfamily
XFF4834R_RS20920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFF4834R_RS20925	COG0861	Integral membrane protein TerC family
XFF4834R_RS20935	COG0584	glycerophosphoryl diester phosphodiesterase
XFF4834R_RS20950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFF4834R_RS20960	COG0706	membrane insertase activity
XFF4834R_RS20965	COG0594	ribonuclease P activity
XFF4834R_RS21195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFF4834R_RS21370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFF4834R_RS21385	COG0187	DNA topoisomerase II activity
XFF4834R_RS21390	COG0187	DNA topoisomerase II activity
XFF4834R_RS21465	COG4942	peptidase