locus-tag	class	description
BI317_RS00005	COG1074	ATP-dependent DNA helicase activity
BI317_RS00010	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI317_RS00015	COG1127	ABC transporter
BI317_RS00020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI317_RS00025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI317_RS00040	COG2853	Lipoprotein
BI317_RS00065	COG0386	Belongs to the glutathione peroxidase family
BI317_RS00075	COG1322	Protein conserved in bacteria
BI317_RS00080	COG0625	glutathione transferase activity
BI317_RS00085	COG0531	amino acid
BI317_RS00090	COG3537	Alpha-1,2-mannosidase
BI317_RS00105	COG2203	Gaf domain
BI317_RS00105	COG2199	diguanylate cyclase activity
BI317_RS00110	COG3835	regulator
BI317_RS00115	COG1929	Belongs to the glycerate kinase type-1 family
BI317_RS00120	COG2271	Major facilitator Superfamily
BI317_RS00160	COG1126	abc transporter atp-binding protein
BI317_RS00170	COG1473	amidohydrolase
BI317_RS00175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI317_RS00180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI317_RS00190	COG4206	TonB-dependent receptor
BI317_RS00210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI317_RS00220	COG0861	Integral membrane protein TerC family
BI317_RS00240	COG0584	glycerophosphoryl diester phosphodiesterase
BI317_RS00265	COG0706	membrane insertase activity
BI317_RS00300	COG0187	DNA topoisomerase II activity
BI317_RS00310	COG0501	Belongs to the peptidase M48B family
BI317_RS00345	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI317_RS00355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI317_RS00385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI317_RS00390	COG0793	Belongs to the peptidase S41A family
BI317_RS00395	COG4942	peptidase
BI317_RS00405	COG2234	aminopeptidase activity
BI317_RS00415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI317_RS00425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI317_RS00430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI317_RS00435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI317_RS00440	COG1064	alcohol dehydrogenase
BI317_RS00450	COG0493	'glutamate synthase
BI317_RS00455	COG0067	glutamate synthase
BI317_RS00455	COG0070	glutamate synthase
BI317_RS00455	COG0069	glutamate synthase activity
BI317_RS00485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI317_RS00500	COG3459	Glycosyltransferase 36 associated
BI317_RS00525	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS00610	COG1205	dead DEAH box helicase
BI317_RS00610	COG1111	helicase
BI317_RS00620	COG1272	protein, Hemolysin III
BI317_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS00665	COG0583	DNA-binding transcription factor activity
BI317_RS00670	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS00685	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI317_RS00700	COG1733	regulation of RNA biosynthetic process
BI317_RS00745	COG3237	CsbD-like
BI317_RS00780	COG2816	NAD+ diphosphatase activity
BI317_RS00795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI317_RS00905	COG4772	TonB-dependent receptor
BI317_RS00915	COG0662	Cupin 2, conserved barrel domain protein
BI317_RS00925	COG1012	belongs to the aldehyde dehydrogenase family
BI317_RS00980	COG1755	Isoprenylcysteine carboxyl methyltransferase
BI317_RS00985	COG4585	Histidine kinase
BI317_RS00990	COG2197	response regulator
BI317_RS01005	COG3710	Transcriptional regulator
BI317_RS01010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI317_RS01020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI317_RS01025	COG4771	TonB-dependent receptor
BI317_RS01155	COG3550	peptidyl-serine autophosphorylation
BI317_RS01205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI317_RS01215	COG4221	oxidoreductase activity
BI317_RS01220	COG0583	DNA-binding transcription factor activity
BI317_RS01225	COG0477	Major facilitator Superfamily
BI317_RS01230	COG1289	transmembrane transporter activity
BI317_RS01240	COG1566	PFAM secretion protein HlyD family protein
BI317_RS01255	COG0302	gtp cyclohydrolase
BI317_RS01285	COG0730	response to heat
BI317_RS01300	COG0676	glucose-6-phosphate 1-epimerase activity
BI317_RS01350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI317_RS01360	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BI317_RS01370	COG1435	thymidine kinase activity
BI317_RS01375	COG0210	DNA helicase
BI317_RS01395	COG3132	Protein of unknown function, DUF480
BI317_RS01400	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BI317_RS01405	COG0284	orotidine-5'-phosphate decarboxylase activity
BI317_RS01430	COG2937	Belongs to the GPAT DAPAT family
BI317_RS01475	COG2211	Major facilitator Superfamily
BI317_RS01490	COG3693	PFAM glycoside hydrolase, family 10
BI317_RS01495	COG1904	glucuronate isomerase
BI317_RS01500	COG3250	beta-galactosidase activity
BI317_RS01510	COG3386	PFAM SMP-30 Gluconolaconase
BI317_RS01520	COG1620	l-lactate permease
BI317_RS01525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI317_RS01550	COG0246	Mannitol dehydrogenase
BI317_RS01555	COG1472	Belongs to the glycosyl hydrolase 3 family
BI317_RS01565	COG4948	Mandelate Racemase Muconate Lactonizing
BI317_RS01585	COG2115	Belongs to the xylose isomerase family
BI317_RS01590	COG0037	tRNA processing
BI317_RS01595	COG2974	May be involved in recombination
BI317_RS01615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI317_RS01625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI317_RS01630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI317_RS01635	COG0805	protein transport
BI317_RS01645	COG0519	Catalyzes the synthesis of GMP from XMP
BI317_RS01645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI317_RS01660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI317_RS01675	COG0729	surface antigen
BI317_RS01680	COG2911	Protein conserved in bacteria
BI317_RS01715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI317_RS01720	COG3265	gluconokinase activity
BI317_RS01725	COG2211	Major facilitator Superfamily
BI317_RS01730	COG3459	Glycosyltransferase 36 associated
BI317_RS01740	COG2205	protein histidine kinase activity
BI317_RS01745	COG1971	Probably functions as a manganese efflux pump
BI317_RS01760	COG1414	Transcriptional regulator
BI317_RS01765	COG0738	Major facilitator superfamily
BI317_RS01770	COG3254	rhamnose metabolic process
BI317_RS01775	COG4948	Mandelate Racemase Muconate Lactonizing
BI317_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS01855	COG3162	membrane
BI317_RS01860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI317_RS01880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI317_RS01890	COG1940	carbohydrate kinase activity
BI317_RS01905	COG0708	Exodeoxyribonuclease III
BI317_RS01920	COG2091	lysine biosynthetic process via aminoadipic acid
BI317_RS01930	COG3540	Alkaline phosphatase
BI317_RS01965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI317_RS01985	COG2159	amidohydrolase
BI317_RS01995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI317_RS02005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI317_RS02020	COG0210	DNA helicase
BI317_RS02045	COG3621	Patatin-like phospholipase
BI317_RS02075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI317_RS02075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI317_RS02125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI317_RS02140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI317_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS02210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI317_RS02215	COG3100	YcgL domain-containing protein
BI317_RS02230	COG3387	PFAM Glycoside hydrolase 15-related
BI317_RS02235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI317_RS02250	COG2239	Acts as a magnesium transporter
BI317_RS02255	COG1629	transport
BI317_RS02255	COG4771	TonB-dependent receptor
BI317_RS02270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI317_RS02270	COG1042	CoA-binding domain protein
BI317_RS02270	COG0045	succinate-CoA ligase (ADP-forming) activity
BI317_RS02290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI317_RS02300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI317_RS02315	COG1607	acyl-coa hydrolase
BI317_RS02335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI317_RS02345	COG0842	Transport permease protein
BI317_RS02350	COG1131	(ABC) transporter
BI317_RS02355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI317_RS02380	COG1476	TRANSCRIPTIONal
BI317_RS02390	COG4555	ABC transporter
BI317_RS02425	COG0625	glutathione transferase activity
BI317_RS02465	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI317_RS02510	COG1199	ATP-dependent helicase activity
BI317_RS02535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI317_RS02545	COG0745	RESPONSE REGULATOR receiver
BI317_RS02550	COG2205	protein histidine kinase activity
BI317_RS02565	COG3228	Belongs to the MtfA family
BI317_RS02575	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BI317_RS02575	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BI317_RS02580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI317_RS02595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI317_RS02635	COG3237	CsbD-like
BI317_RS02640	COG0180	Tryptophanyl-tRNA synthetase
BI317_RS02680	COG0697	spore germination
BI317_RS02705	COG1136	(ABC) transporter
BI317_RS02710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI317_RS02715	COG4585	Histidine kinase
BI317_RS02720	COG2197	response regulator
BI317_RS02745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI317_RS02750	COG1011	Hydrolase
BI317_RS02775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI317_RS02795	COG0642	Histidine kinase
BI317_RS02805	COG1090	epimerase
BI317_RS02855	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI317_RS02870	COG0606	chelatase, subunit chli
BI317_RS02875	COG2960	long-chain fatty acid transporting porin activity
BI317_RS02910	COG1166	arginine decarboxylase activity
BI317_RS02915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI317_RS02925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI317_RS02925	COG2755	lipolytic protein G-D-S-L family
BI317_RS02930	COG4221	oxidoreductase activity
BI317_RS02940	COG0018	arginyl-trna synthetase
BI317_RS02950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI317_RS02955	COG0756	dUTP diphosphatase activity
BI317_RS02975	COG0463	Glycosyl transferase, family 2
BI317_RS02990	COG1475	DNA binding
BI317_RS02995	COG1192	Involved in chromosome partitioning
BI317_RS03010	COG0708	Exodeoxyribonuclease III
BI317_RS03015	COG2807	transmembrane transport
BI317_RS03030	COG0739	heme binding
BI317_RS03075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI317_RS03085	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI317_RS03115	COG0109	protoheme IX farnesyltransferase activity
BI317_RS03130	COG0358	DNA primase activity
BI317_RS03135	COG1295	ribonuclease BN
BI317_RS03140	COG1610	YqeY-like protein
BI317_RS03155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI317_RS03175	COG2133	pyrroloquinoline quinone binding
BI317_RS03180	COG4682	membrane
BI317_RS03195	COG0531	amino acid
BI317_RS03210	COG5383	Protein conserved in bacteria
BI317_RS03250	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BI317_RS03255	COG3023	N-Acetylmuramoyl-L-alanine amidase
BI317_RS03265	COG4948	Mandelate Racemase Muconate Lactonizing
BI317_RS03280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI317_RS03285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI317_RS03290	COG1473	amidohydrolase
BI317_RS03295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI317_RS03295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI317_RS03325	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI317_RS03345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI317_RS03350	COG3118	belongs to the thioredoxin family
BI317_RS03360	COG2884	Cell division ATP-binding protein ftsE
BI317_RS03365	COG2177	Part of the ABC transporter FtsEX involved in
BI317_RS03370	COG2201	protein-glutamate methylesterase activity
BI317_RS03375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI317_RS03380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI317_RS03385	COG2860	membrane
BI317_RS03405	COG0625	glutathione transferase activity
BI317_RS03420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI317_RS03435	COG0534	Mate efflux family protein
BI317_RS03440	COG0616	signal peptide processing
BI317_RS03450	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS03465	COG0009	L-threonylcarbamoyladenylate synthase
BI317_RS03470	COG1754	DNA topoisomerase type I activity
BI317_RS03470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI317_RS03490	COG0758	DNA mediated transformation
BI317_RS03495	COG1652	LysM domain
BI317_RS03500	COG0242	peptide deformylase activity
BI317_RS03505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI317_RS03510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI317_RS03510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI317_RS03560	COG1560	Kdo2-lipid A biosynthetic process
BI317_RS03565	COG1490	D-aminoacyl-tRNA deacylase activity
BI317_RS03570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI317_RS03650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI317_RS03655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI317_RS03675	COG2198	Histidine kinase
BI317_RS03675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI317_RS03675	COG2205	protein histidine kinase activity
BI317_RS03675	COG0784	Response regulator, receiver
BI317_RS03700	COG2813	Specifically methylates the guanine in position
BI317_RS03705	COG1187	pseudouridine synthase activity
BI317_RS03725	COG1666	GTP binding
BI317_RS03730	COG0697	spore germination
BI317_RS03735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI317_RS03740	COG2011	ABC-type metal ion transport system permease component
BI317_RS03770	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI317_RS03780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI317_RS03795	COG0356	it plays a direct role in the translocation of protons across the membrane
BI317_RS03805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI317_RS03830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI317_RS03845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI317_RS03865	COG4191	Histidine kinase
BI317_RS03875	COG0577	efflux transmembrane transporter activity
BI317_RS03885	COG1136	(ABC) transporter
BI317_RS03895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI317_RS03900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI317_RS03945	COG0339	signal peptide processing
BI317_RS03960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI317_RS03965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI317_RS03970	COG0546	phosphoglycolate phosphatase activity
BI317_RS03980	COG2819	hydrolase of the alpha beta superfamily
BI317_RS03990	COG1956	GAF domain-containing protein
BI317_RS03995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BI317_RS04005	COG0720	synthase
BI317_RS04010	COG4771	TonB-dependent receptor
BI317_RS04020	COG0513	Belongs to the DEAD box helicase family
BI317_RS04035	COG0625	glutathione transferase activity
BI317_RS04105	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BI317_RS04130	COG0463	Glycosyl transferase, family 2
BI317_RS04150	COG2086	electron transfer activity
BI317_RS04175	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BI317_RS04175	COG0662	Cupin 2, conserved barrel domain protein
BI317_RS04180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI317_RS04225	COG3218	ABC-type transport auxiliary lipoprotein component
BI317_RS04225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI317_RS04230	COG1127	ABC transporter
BI317_RS04235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI317_RS04250	COG0442	prolyl-tRNA aminoacylation
BI317_RS04260	COG1183	phosphatidylcholine synthase activity
BI317_RS04290	COG0525	valine-tRNA ligase activity
BI317_RS04310	COG0795	lipopolysaccharide-transporting ATPase activity
BI317_RS04325	COG4974	Belongs to the 'phage' integrase family
BI317_RS04330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI317_RS04335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI317_RS04335	COG0047	phosphoribosylformylglycinamidine synthase activity
BI317_RS04345	COG1404	Belongs to the peptidase S8 family
BI317_RS04350	COG5295	Hep Hag repeat protein
BI317_RS04355	COG1404	Belongs to the peptidase S8 family
BI317_RS04360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI317_RS04365	COG1459	type II secretion system
BI317_RS04370	COG2165	general secretion pathway protein
BI317_RS04375	COG4970	Tfp pilus assembly protein FimT
BI317_RS04380	COG2165	general secretion pathway protein
BI317_RS04385	COG4795	General secretion pathway protein
BI317_RS04390	COG3156	type II secretion system protein K
BI317_RS04395	COG3166	PFAM Fimbrial assembly family protein
BI317_RS04410	COG1450	Type ii and iii secretion system protein
BI317_RS04455	COG2188	Transcriptional regulator
BI317_RS04510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI317_RS04525	COG0242	peptide deformylase activity
BI317_RS04530	COG0488	(ABC) transporter
BI317_RS04540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI317_RS04555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI317_RS04555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI317_RS04595	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BI317_RS04620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI317_RS04625	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BI317_RS04635	COG2205	protein histidine kinase activity
BI317_RS04640	COG0745	RESPONSE REGULATOR receiver
BI317_RS04645	COG0277	FAD linked oxidase domain protein
BI317_RS04650	COG1988	membrane-bound metal-dependent
BI317_RS04655	COG0792	nuclease activity
BI317_RS04700	COG3116	cell division
BI317_RS04710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI317_RS04715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI317_RS04735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI317_RS04740	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI317_RS04745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI317_RS04770	COG0739	heme binding
BI317_RS04775	COG0653	protein targeting
BI317_RS04785	COG0494	nUDIX hydrolase
BI317_RS04805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI317_RS04815	COG3321	synthase
BI317_RS04815	COG0604	alcohol dehydrogenase
BI317_RS04815	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS04880	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI317_RS04900	COG2885	chlorophyll binding
BI317_RS04915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI317_RS04925	COG4106	trans-aconitate 2-methyltransferase activity
BI317_RS04930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI317_RS04945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI317_RS04950	COG0667	Aldo Keto reductase
BI317_RS04960	COG4771	TonB-dependent receptor
BI317_RS05025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BI317_RS05035	COG2175	clavaminate synthase activity
BI317_RS05045	COG4181	ATPase activity
BI317_RS05060	COG0642	Histidine kinase
BI317_RS05070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI317_RS05090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI317_RS05110	COG1116	anion transmembrane transporter activity
BI317_RS05115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI317_RS05125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI317_RS05130	COG0431	NADPH-dependent FMN reductase
BI317_RS05135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI317_RS05140	COG2967	ApaG domain
BI317_RS05145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI317_RS05160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI317_RS05165	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI317_RS05170	COG2096	Adenosyltransferase
BI317_RS05180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI317_RS05185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI317_RS05215	COG3384	dioxygenase
BI317_RS05220	COG0583	DNA-binding transcription factor activity
BI317_RS05225	COG0318	PFAM AMP-dependent synthetase and ligase
BI317_RS05235	COG1024	Enoyl-CoA hydratase
BI317_RS05260	COG3386	PFAM SMP-30 Gluconolaconase
BI317_RS05290	COG0697	spore germination
BI317_RS05295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI317_RS05315	COG0784	Response regulator, receiver
BI317_RS05315	COG5002	protein histidine kinase activity
BI317_RS05315	COG2205	protein histidine kinase activity
BI317_RS05320	COG2197	response regulator
BI317_RS05330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI317_RS05340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI317_RS05345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI317_RS05350	COG0583	DNA-binding transcription factor activity
BI317_RS05355	COG3634	alkyl hydroperoxide reductase activity
BI317_RS05365	COG2890	protein-(glutamine-N5) methyltransferase activity
BI317_RS05385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI317_RS05385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI317_RS05435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI317_RS05440	COG1404	Belongs to the peptidase S8 family
BI317_RS05445	COG1404	Belongs to the peptidase S8 family
BI317_RS05450	COG1404	Belongs to the peptidase S8 family
BI317_RS05475	COG1295	ribonuclease BN
BI317_RS05480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI317_RS05500	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI317_RS05520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BI317_RS05530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI317_RS05545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI317_RS05550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI317_RS05555	COG0193	aminoacyl-tRNA hydrolase activity
BI317_RS05560	COG0012	GTP binding
BI317_RS05595	COG0250	Participates in transcription elongation, termination and antitermination
BI317_RS05600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI317_RS05605	COG0081	regulation of translation
BI317_RS05610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI317_RS05615	COG0222	ribosome binding
BI317_RS05625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI317_RS05630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BI317_RS05645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI317_RS05650	COG0051	transcription antitermination factor activity, RNA binding
BI317_RS05670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI317_RS05680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BI317_RS05695	COG0255	Belongs to the universal ribosomal protein uL29 family
BI317_RS05700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI317_RS05710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI317_RS05755	COG0201	protein transport
BI317_RS05780	COG0203	ribosomal protein L17
BI317_RS05795	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BI317_RS05805	COG0154	amidase activity
BI317_RS05820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI317_RS05830	COG0625	glutathione transferase activity
BI317_RS05845	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI317_RS05845	COG1902	pentaerythritol trinitrate reductase activity
BI317_RS05850	COG0604	alcohol dehydrogenase
BI317_RS05855	COG2885	chlorophyll binding
BI317_RS05875	COG0156	8-amino-7-oxononanoate synthase activity
BI317_RS05880	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI317_RS05885	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI317_RS05890	COG4208	sulfate ABC transporter
BI317_RS05895	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI317_RS05905	COG1063	alcohol dehydrogenase
BI317_RS05925	COG0406	alpha-ribazole phosphatase activity
BI317_RS05935	COG0285	dihydrofolate synthase activity
BI317_RS05955	COG2833	Protein of unknown function (DUF455)
BI317_RS05960	COG3291	Pkd domain containing protein
BI317_RS05970	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI317_RS05975	COG0671	phosphoesterase, PA-phosphatase related
BI317_RS05990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI317_RS06000	COG0745	RESPONSE REGULATOR receiver
BI317_RS06005	COG4783	chaperone-mediated protein folding
BI317_RS06020	COG0473	3-isopropylmalate dehydrogenase activity
BI317_RS06300	COG4695	Portal protein
BI317_RS06350	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI317_RS06360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI317_RS06390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI317_RS06400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI317_RS06415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI317_RS06420	COG0631	protein serine/threonine phosphatase activity
BI317_RS06435	COG0859	PFAM glycosyl transferase family 9
BI317_RS06445	COG1234	tRNA 3'-trailer cleavage
BI317_RS06450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI317_RS06455	COG0315	cyclic pyranopterin monophosphate synthase activity
BI317_RS06460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI317_RS06465	COG0314	molybdopterin synthase activity
BI317_RS06485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI317_RS06495	COG0537	adenosine 5'-monophosphoramidase activity
BI317_RS06515	COG0714	Associated with various cellular activities
BI317_RS06535	COG0424	maF-like protein
BI317_RS06540	COG1399	metal-binding, possibly nucleic acid-binding protein
BI317_RS06545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI317_RS06550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI317_RS06560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BI317_RS06580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI317_RS06585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI317_RS06605	COG4115	mRNA cleavage
BI317_RS06610	COG2161	toxin-antitoxin pair type II binding
BI317_RS06620	COG3829	transcription factor binding
BI317_RS06660	COG2373	Large extracellular alpha-helical protein
BI317_RS06680	COG4953	penicillin-binding protein 1C
BI317_RS06690	COG0678	peroxiredoxin activity
BI317_RS06710	COG0330	HflC and HflK could
BI317_RS06715	COG0330	HflC and HflK could
BI317_RS06760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BI317_RS06775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI317_RS06855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI317_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS06880	COG3537	Alpha-1,2-mannosidase
BI317_RS06935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI317_RS06940	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI317_RS06945	COG2080	2 iron, 2 sulfur cluster binding
BI317_RS07000	COG0587	DNA-directed DNA polymerase activity
BI317_RS07015	COG1297	OPT oligopeptide transporter protein
BI317_RS07025	COG0823	Involved in the tonB-independent uptake of proteins
BI317_RS07025	COG1506	peptidase
BI317_RS07035	COG2207	Transcriptional regulator
BI317_RS07035	COG1917	Cupin 2, conserved barrel domain protein
BI317_RS07045	COG0753	catalase activity
BI317_RS07055	COG0656	L-ascorbic acid biosynthetic process
BI317_RS07065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI317_RS07065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI317_RS07070	COG2814	Major facilitator Superfamily
BI317_RS07095	COG2194	sulfuric ester hydrolase activity
BI317_RS07110	COG0745	RESPONSE REGULATOR receiver
BI317_RS07115	COG5002	protein histidine kinase activity
BI317_RS07125	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI317_RS07130	COG2894	cell division
BI317_RS07145	COG4585	Histidine kinase
BI317_RS07150	COG2197	response regulator
BI317_RS07165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI317_RS07215	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI317_RS07230	COG1595	DNA-templated transcription, initiation
BI317_RS07240	COG1946	Acyl-CoA thioesterase
BI317_RS07245	COG1024	Enoyl-CoA hydratase
BI317_RS07255	COG0824	Thioesterase
BI317_RS07260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI317_RS07270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI317_RS07275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI317_RS07290	COG0196	riboflavin kinase activity
BI317_RS07300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI317_RS07320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI317_RS07325	COG1845	cytochrome c oxidase, subunit III
BI317_RS07330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI317_RS07345	COG3152	Membrane
BI317_RS07355	COG2207	Transcriptional regulator
BI317_RS07360	COG0326	Molecular chaperone. Has ATPase activity
BI317_RS07375	COG1902	pentaerythritol trinitrate reductase activity
BI317_RS07380	COG1366	Belongs to the anti-sigma-factor antagonist family
BI317_RS07385	COG1366	Belongs to the anti-sigma-factor antagonist family
BI317_RS07390	COG2172	sigma factor antagonist activity
BI317_RS07415	COG4771	TonB-dependent receptor
BI317_RS07425	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI317_RS07430	COG2205	protein histidine kinase activity
BI317_RS07435	COG2201	protein-glutamate methylesterase activity
BI317_RS07440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI317_RS07445	COG3437	response regulator, receiver
BI317_RS07445	COG4999	Histidine kinase
BI317_RS07445	COG2205	protein histidine kinase activity
BI317_RS07445	COG3850	Histidine kinase
BI317_RS07450	COG4191	Histidine kinase
BI317_RS07450	COG0784	Response regulator, receiver
BI317_RS07475	COG3534	alpha-L-arabinofuranosidase
BI317_RS07515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI317_RS07540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI317_RS07545	COG0336	Belongs to the RNA methyltransferase TrmD family
BI317_RS07555	COG0534	Mate efflux family protein
BI317_RS07570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BI317_RS07580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI317_RS07615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI317_RS07635	COG0583	DNA-binding transcription factor activity
BI317_RS07640	COG1301	dicarboxylic acid transport
BI317_RS07645	COG4948	Mandelate Racemase Muconate Lactonizing
BI317_RS07650	COG3250	beta-galactosidase activity
BI317_RS07655	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BI317_RS07675	COG1960	acyl-CoA dehydrogenase activity
BI317_RS07680	COG1024	Enoyl-CoA hydratase
BI317_RS07720	COG0457	Tetratricopeptide repeat
BI317_RS07730	COG1024	Enoyl-CoA hydratase
BI317_RS07730	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI317_RS07745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI317_RS07770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BI317_RS07775	COG1381	Involved in DNA repair and RecF pathway recombination
BI317_RS07800	COG2954	triphosphatase activity
BI317_RS07805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI317_RS07810	COG1233	COG1233 Phytoene dehydrogenase and related
BI317_RS07815	COG3046	protein related to deoxyribodipyrimidine photolyase
BI317_RS07820	COG1472	Belongs to the glycosyl hydrolase 3 family
BI317_RS07830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BI317_RS07835	COG1278	Cold shock
BI317_RS07850	COG1201	RNA secondary structure unwinding
BI317_RS07855	COG1793	dna ligase
BI317_RS07865	COG1793	dna ligase
BI317_RS07865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI317_RS07895	COG0183	Belongs to the thiolase family
BI317_RS07915	COG1451	nucleotide metabolic process
BI317_RS07920	COG5487	UPF0391 membrane protein
BI317_RS07930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI317_RS07970	COG1047	Peptidyl-prolyl cis-trans
BI317_RS07980	COG2824	Alkylphosphonate utilization operon protein PhnA
BI317_RS07995	COG1902	pentaerythritol trinitrate reductase activity
BI317_RS08035	COG0392	lysyltransferase activity
BI317_RS08035	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BI317_RS08045	COG0251	oxidation-reduction process
BI317_RS08090	COG1595	DNA-templated transcription, initiation
BI317_RS08105	COG2878	Part of a membrane complex involved in electron transport
BI317_RS08115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI317_RS08115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI317_RS08130	COG1131	(ABC) transporter
BI317_RS08135	COG0346	lactoylglutathione lyase activity
BI317_RS08140	COG0833	amino acid
BI317_RS08145	COG2040	homocysteine
BI317_RS08165	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI317_RS08205	COG1695	Transcriptional regulator
BI317_RS08250	COG0825	malonyl-CoA metabolic process
BI317_RS08265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI317_RS08270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI317_RS08275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI317_RS08280	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI317_RS08295	COG0750	zinc metalloprotease
BI317_RS08300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI317_RS08305	COG0575	Belongs to the CDS family
BI317_RS08310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BI317_RS08320	COG0528	UMP kinase activity
BI317_RS08330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI317_RS08335	COG0052	Belongs to the universal ribosomal protein uS2 family
BI317_RS08380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BI317_RS08395	COG1393	Belongs to the ArsC family
BI317_RS08400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI317_RS08405	COG0367	asparagine synthase
BI317_RS08415	COG4774	siderophore transport
BI317_RS08470	COG1566	PFAM secretion protein HlyD family protein
BI317_RS08475	COG2814	Major facilitator Superfamily
BI317_RS08505	COG3104	oligopeptide transport
BI317_RS08535	COG0339	signal peptide processing
BI317_RS08540	COG0386	Belongs to the glutathione peroxidase family
BI317_RS08570	COG0288	reversible hydration of carbon dioxide
BI317_RS08605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI317_RS08610	COG0084	hydrolase, TatD family'
BI317_RS08625	COG1960	acyl-CoA dehydrogenase activity
BI317_RS08640	COG0367	asparagine synthase
BI317_RS08650	COG0305	Participates in initiation and elongation during chromosome replication
BI317_RS08660	COG0415	Belongs to the DNA photolyase family
BI317_RS08675	COG3118	belongs to the thioredoxin family
BI317_RS08685	COG0495	leucyl-tRNA aminoacylation
BI317_RS08700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI317_RS08720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BI317_RS08740	COG1530	ribonuclease E activity
BI317_RS08745	COG3164	Protein of unknown function
BI317_RS08755	COG0312	modulator of DNA gyrase
BI317_RS08765	COG0312	modulator of DNA gyrase
BI317_RS08775	COG4104	PAAR repeat-containing protein
BI317_RS08780	COG0142	geranyltranstransferase activity
BI317_RS08785	COG1722	exodeoxyribonuclease VII activity
BI317_RS08790	COG0037	tRNA processing
BI317_RS08795	COG1785	Belongs to the alkaline phosphatase family
BI317_RS08800	COG1301	dicarboxylic acid transport
BI317_RS08815	COG0791	NLP P60 protein
BI317_RS08820	COG0791	NLP P60 protein
BI317_RS08825	COG1047	Peptidyl-prolyl cis-trans
BI317_RS08830	COG2311	Membrane
BI317_RS08835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI317_RS08860	COG3590	peptidase
BI317_RS08895	COG0489	protein tyrosine kinase activity
BI317_RS08905	COG0717	Belongs to the dCTP deaminase family
BI317_RS08930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI317_RS08950	COG1472	Belongs to the glycosyl hydrolase 3 family
BI317_RS08980	COG0494	nUDIX hydrolase
BI317_RS08990	COG0433	COG0433 Predicted ATPase
BI317_RS09000	COG0688	phosphatidylethanolamine metabolic process
BI317_RS09010	COG2890	protein-(glutamine-N5) methyltransferase activity
BI317_RS09025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI317_RS09030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI317_RS09045	COG0101	tRNA pseudouridine synthase activity
BI317_RS09050	COG0135	phosphoribosylanthranilate isomerase activity
BI317_RS09060	COG0133	tryptophan synthase activity
BI317_RS09070	COG0159	tryptophan synthase activity
BI317_RS09080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI317_RS09115	COG4221	oxidoreductase activity
BI317_RS09135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI317_RS09145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI317_RS09150	COG0649	NAD binding
BI317_RS09155	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BI317_RS09160	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BI317_RS09170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BI317_RS09180	COG0839	Belongs to the complex I subunit 6 family
BI317_RS09200	COG1007	ATP synthesis coupled electron transport
BI317_RS09210	COG0779	Required for maturation of 30S ribosomal subunits
BI317_RS09215	COG0195	Participates in both transcription termination and antitermination
BI317_RS09225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI317_RS09230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI317_RS09235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI317_RS09280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI317_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS09290	COG2095	MarC family integral membrane protein
BI317_RS09300	COG1611	Belongs to the LOG family
BI317_RS09345	COG0556	nucleotide-excision repair
BI317_RS09360	COG3505	Type IV secretory pathway VirD4
BI317_RS09380	COG2948	multi-organism process
BI317_RS09400	COG3702	type iv secretory pathway
BI317_RS09485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI317_RS09490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI317_RS09505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI317_RS09510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI317_RS09510	COG0072	phenylalanine-tRNA ligase activity
BI317_RS09560	COG0438	transferase activity, transferring glycosyl groups
BI317_RS09565	COG0438	transferase activity, transferring glycosyl groups
BI317_RS09575	COG0438	transferase activity, transferring glycosyl groups
BI317_RS09600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI317_RS09605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI317_RS09610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI317_RS09635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI317_RS09655	COG3040	lipid binding
BI317_RS09820	COG0740	serine-type endopeptidase activity
BI317_RS09990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI317_RS10025	COG1194	a g-specific adenine glycosylase
BI317_RS10030	COG0552	protein localization to endoplasmic reticulum
BI317_RS10040	COG3938	Belongs to the proline racemase family
BI317_RS10045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI317_RS10060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI317_RS10070	COG0006	proline dipeptidase activity
BI317_RS10085	COG0531	amino acid
BI317_RS10190	COG0742	ribosomal rna small subunit methyltransferase
BI317_RS10210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI317_RS10215	COG0405	Gamma-glutamyltransferase
BI317_RS10225	COG3291	Pkd domain containing protein
BI317_RS10265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI317_RS10275	COG1862	Preprotein translocase
BI317_RS10285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI317_RS10370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI317_RS10370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI317_RS10375	COG1105	Belongs to the carbohydrate kinase PfkB family
BI317_RS10380	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI317_RS10380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI317_RS10385	COG1609	Transcriptional regulator
BI317_RS10390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI317_RS10395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI317_RS10405	COG2902	Dehydrogenase
BI317_RS10445	COG1064	alcohol dehydrogenase
BI317_RS10455	COG1902	pentaerythritol trinitrate reductase activity
BI317_RS10475	COG0300	oxidoreductase activity
BI317_RS10480	COG0604	alcohol dehydrogenase
BI317_RS10490	COG0477	Major facilitator Superfamily
BI317_RS10500	COG2205	protein histidine kinase activity
BI317_RS10500	COG0784	Response regulator, receiver
BI317_RS10500	COG5002	protein histidine kinase activity
BI317_RS10505	COG2733	membrane
BI317_RS10520	COG2223	nitrite transmembrane transporter activity
BI317_RS10530	COG0243	molybdopterin cofactor binding
BI317_RS10570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI317_RS10575	COG0174	glutamine synthetase
BI317_RS10580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI317_RS10615	COG3842	ATPase activity
BI317_RS10625	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI317_RS10630	COG1177	transmembrane transport
BI317_RS10640	COG1012	belongs to the aldehyde dehydrogenase family
BI317_RS10660	COG4535	Mg2 and Co2 transporter CorC
BI317_RS10680	COG1702	phosphate starvation-inducible protein PhoH
BI317_RS10685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI317_RS10700	COG0741	lytic transglycosylase activity
BI317_RS10705	COG0723	plastoquinol--plastocyanin reductase activity
BI317_RS10710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BI317_RS10715	COG2857	Cytochrome c1
BI317_RS10725	COG0625	glutathione transferase activity
BI317_RS10730	COG2969	positive regulation of protein catabolic process
BI317_RS10740	COG1201	RNA secondary structure unwinding
BI317_RS10750	COG0840	transmembrane signaling receptor activity
BI317_RS10755	COG0835	chemotaxis
BI317_RS10760	COG2199	diguanylate cyclase activity
BI317_RS10780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI317_RS10800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI317_RS10805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI317_RS10805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI317_RS10815	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI317_RS10820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI317_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS10845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI317_RS10850	COG0501	Belongs to the peptidase M48B family
BI317_RS10860	COG3300	MHYT domain
BI317_RS10860	COG5001	Diguanylate cyclase
BI317_RS10865	COG2081	HI0933 family
BI317_RS10870	COG4681	YaeQ
BI317_RS10875	COG1671	Belongs to the UPF0178 family
BI317_RS10885	COG0625	glutathione transferase activity
BI317_RS10895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI317_RS10900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI317_RS10905	COG0513	Belongs to the DEAD box helicase family
BI317_RS10920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI317_RS10930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BI317_RS10935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI317_RS10940	COG0259	pyridoxamine-phosphate oxidase activity
BI317_RS10955	COG1842	Phage shock protein A
BI317_RS10980	COG0754	glutathionylspermidine amidase activity
BI317_RS10985	COG2814	Major facilitator Superfamily
BI317_RS11040	COG0531	amino acid
BI317_RS11045	COG2197	response regulator
BI317_RS11060	COG1113	amino acid transport
BI317_RS11070	COG1271	oxidase subunit
BI317_RS11075	COG1294	oxidase, subunit
BI317_RS11085	COG2239	Acts as a magnesium transporter
BI317_RS11090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI317_RS11095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI317_RS11115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI317_RS11130	COG1137	ATPase activity
BI317_RS11135	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI317_RS11145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BI317_RS11155	COG0271	Belongs to the BolA IbaG family
BI317_RS11160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI317_RS11190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI317_RS11205	COG0628	permease
BI317_RS11230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BI317_RS11235	COG0483	inositol monophosphate 1-phosphatase activity
BI317_RS11250	COG5001	Diguanylate cyclase
BI317_RS11250	COG3300	MHYT domain
BI317_RS11255	COG1509	lysine 2,3-aminomutase activity
BI317_RS11270	COG0402	S-adenosylhomocysteine deaminase activity
BI317_RS11275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI317_RS11340	COG4302	ethanolamine ammonia-lyase activity
BI317_RS11345	COG4303	Ethanolamine ammonia lyase large subunit
BI317_RS11360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI317_RS11380	COG2166	iron-sulfur cluster assembly
BI317_RS11400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI317_RS11405	COG0137	argininosuccinate synthase activity
BI317_RS11410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI317_RS11415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI317_RS11430	COG0165	Argininosuccinate lyase
BI317_RS11445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BI317_RS11490	COG4988	ABC transporter
BI317_RS11495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI317_RS11535	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI317_RS11560	COG0436	Aminotransferase
BI317_RS11565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI317_RS11580	COG1187	pseudouridine synthase activity
BI317_RS11585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI317_RS11590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI317_RS11595	COG2350	Protein conserved in bacteria
BI317_RS11620	COG1653	transport
BI317_RS11625	COG1175	transmembrane transport
BI317_RS11630	COG0395	ABC-type sugar transport system, permease component
BI317_RS11655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI317_RS11660	COG2957	Belongs to the agmatine deiminase family
BI317_RS11685	COG0776	regulation of translation
BI317_RS11695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI317_RS11700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI317_RS11715	COG0475	glutathione-regulated potassium exporter activity
BI317_RS11715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI317_RS11725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI317_RS11785	COG1914	H( )-stimulated, divalent metal cation uptake system
BI317_RS11800	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI317_RS11805	COG0668	transmembrane transport
BI317_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS11835	COG1183	phosphatidylcholine synthase activity
BI317_RS11845	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI317_RS11870	COG2183	response to ionizing radiation
BI317_RS11875	COG0784	Response regulator, receiver
BI317_RS11875	COG2205	protein histidine kinase activity
BI317_RS11875	COG5002	protein histidine kinase activity
BI317_RS11950	COG0800	Aldolase
BI317_RS11955	COG0129	dihydroxy-acid dehydratase activity
BI317_RS11960	COG0363	glucosamine-6-phosphate deaminase activity
BI317_RS11965	COG0837	glucose binding
BI317_RS11970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI317_RS11980	COG0354	folic acid binding
BI317_RS11990	COG2009	succinate dehydrogenase
BI317_RS11995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI317_RS12010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI317_RS12015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI317_RS12025	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI317_RS12030	COG1136	(ABC) transporter
BI317_RS12045	COG0811	peptide transport
BI317_RS12055	COG1132	(ABC) transporter
BI317_RS12060	COG1663	tetraacyldisaccharide 4'-kinase activity
BI317_RS12070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI317_RS12075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI317_RS12085	COG0322	excinuclease ABC activity
BI317_RS12090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI317_RS12115	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BI317_RS12145	COG1530	ribonuclease E activity
BI317_RS12240	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI317_RS12420	COG2197	response regulator
BI317_RS12425	COG4191	Histidine kinase
BI317_RS12430	COG3781	membrane
BI317_RS12460	COG2205	protein histidine kinase activity
BI317_RS12465	COG0784	Response regulator, receiver
BI317_RS12465	COG4191	Histidine kinase
BI317_RS12535	COG5001	Diguanylate cyclase
BI317_RS12550	COG3685	Protein conserved in bacteria
BI317_RS12560	COG0579	oxidoreductase
BI317_RS12570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI317_RS12580	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BI317_RS12600	COG0243	molybdopterin cofactor binding
BI317_RS12610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI317_RS12615	COG2223	nitrite transmembrane transporter activity
BI317_RS12625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI317_RS12635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI317_RS12635	COG1648	precorrin-2 dehydrogenase activity
BI317_RS12645	COG0746	molybdenum cofactor guanylyltransferase activity
BI317_RS12650	COG0303	'Molybdopterin
BI317_RS12660	COG0708	Exodeoxyribonuclease III
BI317_RS12670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI317_RS12675	COG0303	'Molybdopterin
BI317_RS12680	COG1160	GTP binding
BI317_RS12685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI317_RS12705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI317_RS12720	COG1024	Enoyl-CoA hydratase
BI317_RS12720	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI317_RS12725	COG0183	Belongs to the thiolase family
BI317_RS12730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI317_RS12735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI317_RS12750	COG1674	ftsk spoiiie
BI317_RS12755	COG0492	ferredoxin-NADP+ reductase activity
BI317_RS12765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BI317_RS12775	COG0542	response to heat
BI317_RS12790	COG0482	sulfurtransferase activity
BI317_RS12850	COG4191	Histidine kinase
BI317_RS12870	COG0835	chemotaxis
BI317_RS12870	COG0784	Response regulator, receiver
BI317_RS12880	COG1558	bacterial-type flagellum-dependent cell motility
BI317_RS12885	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI317_RS12895	COG4787	bacterial-type flagellum-dependent cell motility
BI317_RS12925	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI317_RS12925	COG3951	Flagellar rod assembly protein muramidase FlgJ
BI317_RS12940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI317_RS12945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI317_RS12975	COG2201	protein-glutamate methylesterase activity
BI317_RS12995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI317_RS13000	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS13060	COG1677	Flagellar hook-basal body complex protein FliE
BI317_RS13110	COG3190	flagellar
BI317_RS13130	COG3300	MHYT domain
BI317_RS13130	COG5001	Diguanylate cyclase
BI317_RS13180	COG0643	Histidine kinase
BI317_RS13180	COG0784	Response regulator, receiver
BI317_RS13180	COG2198	Histidine kinase
BI317_RS13195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI317_RS13205	COG1192	Involved in chromosome partitioning
BI317_RS13210	COG0835	chemotaxis
BI317_RS13220	COG0745	RESPONSE REGULATOR receiver
BI317_RS13225	COG0643	Histidine kinase
BI317_RS13225	COG2198	Histidine kinase
BI317_RS13230	COG0840	transmembrane signaling receptor activity
BI317_RS13240	COG0840	transmembrane signaling receptor activity
BI317_RS13240	COG0840	transmembrane signaling receptor activity
BI317_RS13245	COG0840	transmembrane signaling receptor activity
BI317_RS13250	COG0840	transmembrane signaling receptor activity
BI317_RS13255	COG0840	transmembrane signaling receptor activity
BI317_RS13260	COG0840	transmembrane signaling receptor activity
BI317_RS13265	COG0840	transmembrane signaling receptor activity
BI317_RS13270	COG0840	transmembrane signaling receptor activity
BI317_RS13275	COG0840	transmembrane signaling receptor activity
BI317_RS13295	COG0835	chemotaxis
BI317_RS13305	COG0840	transmembrane signaling receptor activity
BI317_RS13320	COG2201	protein-glutamate methylesterase activity
BI317_RS13335	COG2267	carboxylic ester hydrolase activity
BI317_RS13375	COG0784	Response regulator, receiver
BI317_RS13375	COG2198	Histidine kinase
BI317_RS13375	COG2205	protein histidine kinase activity
BI317_RS13380	COG2198	Histidine kinase
BI317_RS13380	COG0784	Response regulator, receiver
BI317_RS13380	COG2205	protein histidine kinase activity
BI317_RS13390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI317_RS13420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI317_RS13430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI317_RS13435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI317_RS13445	COG0505	Belongs to the CarA family
BI317_RS13455	COG2258	MOSC domain
BI317_RS13460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI317_RS13480	COG1024	Enoyl-CoA hydratase
BI317_RS13495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI317_RS13515	COG0277	FAD linked oxidase domain protein
BI317_RS13520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI317_RS13535	COG0531	amino acid
BI317_RS13540	COG0531	amino acid
BI317_RS13565	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BI317_RS13585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI317_RS13585	COG0140	phosphoribosyl-ATP diphosphatase activity
BI317_RS13590	COG0107	imidazoleglycerol-phosphate synthase activity
BI317_RS13605	COG0131	Imidazoleglycerol-phosphate dehydratase
BI317_RS13605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI317_RS13610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI317_RS13615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI317_RS13620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI317_RS13640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI317_RS13665	COG0460	homoserine dehydrogenase
BI317_RS13665	COG0527	aspartate kinase activity
BI317_RS13670	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BI317_RS13715	COG0726	polysaccharide deacetylase
BI317_RS13715	COG1649	PFAM Uncharacterised BCR, COG1649
BI317_RS13765	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BI317_RS13765	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BI317_RS13850	COG0210	DNA helicase
BI317_RS13940	COG2003	Belongs to the UPF0758 family
BI317_RS13980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI317_RS13990	COG3621	Patatin-like phospholipase
BI317_RS14025	COG1012	belongs to the aldehyde dehydrogenase family
BI317_RS14040	COG0167	dihydroorotate dehydrogenase activity
BI317_RS14045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI317_RS14050	COG0697	spore germination
BI317_RS14065	COG0671	phosphoesterase, PA-phosphatase related
BI317_RS14070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI317_RS14080	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI317_RS14090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI317_RS14095	COG3706	GGDEF domain
BI317_RS14095	COG5001	Diguanylate cyclase
BI317_RS14095	COG4251	negative regulation of phosphorylation
BI317_RS14095	COG2203	Gaf domain
BI317_RS14105	COG1472	Belongs to the glycosyl hydrolase 3 family
BI317_RS14140	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI317_RS14145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI317_RS14150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BI317_RS14155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI317_RS14175	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI317_RS14195	COG0477	Major facilitator Superfamily
BI317_RS14200	COG2115	Belongs to the xylose isomerase family
BI317_RS14205	COG1070	Carbohydrate kinase
BI317_RS14215	COG1501	Belongs to the glycosyl hydrolase 31 family
BI317_RS14250	COG0800	Aldolase
BI317_RS14255	COG4948	Mandelate Racemase Muconate Lactonizing
BI317_RS14275	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI317_RS14285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI317_RS14300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI317_RS14305	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI317_RS14320	COG0352	thiamine-phosphate diphosphorylase activity
BI317_RS14320	COG0351	phosphomethylpyrimidine kinase
BI317_RS14345	COG1741	Belongs to the pirin family
BI317_RS14360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI317_RS14365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI317_RS14370	COG2137	regulation of response to DNA damage stimulus
BI317_RS14375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI317_RS14385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI317_RS14390	COG4771	TonB-dependent receptor
BI317_RS14395	COG1546	Belongs to the CinA family
BI317_RS14400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI317_RS14410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI317_RS14415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI317_RS14425	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI317_RS14430	COG1534	Rna-binding protein
BI317_RS14445	COG1238	metal cluster binding
BI317_RS14450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI317_RS14455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI317_RS14460	COG2840	Smr protein MutS2
BI317_RS14470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI317_RS14475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BI317_RS14485	COG0148	phosphopyruvate hydratase activity
BI317_RS14500	COG0504	CTP synthase activity
BI317_RS14540	COG1253	flavin adenine dinucleotide binding
BI317_RS14555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI317_RS14560	COG0477	Major facilitator Superfamily
BI317_RS14575	COG1132	(ABC) transporter
BI317_RS14580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI317_RS14605	COG0438	transferase activity, transferring glycosyl groups
BI317_RS14610	COG0297	glycogen (starch) synthase activity
BI317_RS14615	COG2264	protein methyltransferase activity
BI317_RS14645	COG2244	polysaccharide biosynthetic process
BI317_RS14695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI317_RS14705	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI317_RS14715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI317_RS14755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI317_RS14785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BI317_RS14790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI317_RS14795	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI317_RS14800	COG2080	2 iron, 2 sulfur cluster binding
BI317_RS14820	COG0629	single-stranded DNA binding
BI317_RS14825	COG0142	geranyltranstransferase activity
BI317_RS14845	COG0527	aspartate kinase activity
BI317_RS14850	COG0384	phenazine biosynthesis protein PhzF
BI317_RS14855	COG0384	phenazine biosynthesis protein PhzF
BI317_RS14865	COG1764	response to oxidative stress
BI317_RS14875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI317_RS14880	COG1678	Uncharacterized ACR, COG1678
BI317_RS14885	COG0519	Catalyzes the synthesis of GMP from XMP
BI317_RS14910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI317_RS14925	COG4942	peptidase
BI317_RS14950	COG1959	2 iron, 2 sulfur cluster binding
BI317_RS14955	COG0719	Fe-S assembly protein
BI317_RS14960	COG0396	ATPase activity
BI317_RS14965	COG0719	Fe-S assembly protein
BI317_RS14970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI317_RS14975	COG0456	acetyltransferase
BI317_RS14990	COG4774	siderophore transport
BI317_RS14995	COG3128	pkhd-type hydroxylase
BI317_RS15020	COG1477	protein flavinylation
BI317_RS15025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI317_RS15035	COG1555	photosystem II stabilization
BI317_RS15040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI317_RS15050	COG3178	'Phosphotransferase
BI317_RS15055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI317_RS15090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BI317_RS15105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BI317_RS15110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI317_RS15115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI317_RS15120	COG3115	cell septum assembly
BI317_RS15145	COG0316	Belongs to the HesB IscA family
BI317_RS15155	COG0017	Asparaginyl-tRNA synthetase
BI317_RS15170	COG2808	Putative FMN-binding domain
BI317_RS15175	COG0288	reversible hydration of carbon dioxide
BI317_RS15195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI317_RS15200	COG2925	Exonuclease
BI317_RS15215	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI317_RS15225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI317_RS15285	COG1024	Enoyl-CoA hydratase
BI317_RS15295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI317_RS15320	COG0659	secondary active sulfate transmembrane transporter activity
BI317_RS15345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI317_RS15350	COG0573	inorganic phosphate transmembrane transporter activity
BI317_RS15355	COG0581	inorganic phosphate transmembrane transporter activity
BI317_RS15365	COG0704	Plays a role in the regulation of phosphate uptake
BI317_RS15380	COG3706	GGDEF domain
BI317_RS15385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI317_RS15395	COG0557	exoribonuclease II activity
BI317_RS15415	COG1960	acyl-CoA dehydrogenase activity
BI317_RS15420	COG2226	methyltransferase
BI317_RS15430	COG1410	methionine synthase
BI317_RS15430	COG0646	methionine synthase
BI317_RS15445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI317_RS15470	COG2900	Belongs to the SlyX family
BI317_RS15485	COG0386	Belongs to the glutathione peroxidase family
BI317_RS15495	COG1725	Transcriptional regulator
BI317_RS15500	COG1131	(ABC) transporter
BI317_RS15530	COG1253	flavin adenine dinucleotide binding
BI317_RS15550	COG2850	peptidyl-arginine hydroxylation
BI317_RS15585	COG1132	(ABC) transporter
BI317_RS15590	COG0583	DNA-binding transcription factor activity
BI317_RS15595	COG2274	protein secretion by the type I secretion system
BI317_RS15620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BI317_RS15635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI317_RS15640	COG1420	regulation of RNA biosynthetic process
BI317_RS15645	COG0497	DNA recombination
BI317_RS15655	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI317_RS15670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI317_RS15685	COG0582	viral genome integration into host DNA
BI317_RS15755	COG1196	nuclear chromosome segregation
BI317_RS15940	COG4197	protein conserved in bacteria, prophage-related
BI317_RS16085	COG3706	GGDEF domain
BI317_RS16095	COG3706	GGDEF domain
BI317_RS16115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI317_RS16130	COG0583	DNA-binding transcription factor activity
BI317_RS16140	COG2155	Conserved Protein
BI317_RS16180	COG1132	(ABC) transporter
BI317_RS16200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI317_RS16220	COG1187	pseudouridine synthase activity
BI317_RS16225	COG5001	Diguanylate cyclase
BI317_RS16225	COG5002	protein histidine kinase activity
BI317_RS16235	COG1595	DNA-templated transcription, initiation
BI317_RS16330	COG1404	Belongs to the peptidase S8 family
BI317_RS16340	COG1404	Belongs to the peptidase S8 family
BI317_RS16345	COG0667	Aldo Keto reductase
BI317_RS16350	COG2814	Major facilitator Superfamily
BI317_RS16355	COG0583	DNA-binding transcription factor activity
BI317_RS16385	COG0667	Aldo Keto reductase
BI317_RS16390	COG1309	transcriptional regulator
BI317_RS16400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI317_RS16420	COG0735	belongs to the Fur family
BI317_RS16425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI317_RS16450	COG4452	Inner membrane protein CreD
BI317_RS16460	COG2205	protein histidine kinase activity
BI317_RS16465	COG0745	RESPONSE REGULATOR receiver
BI317_RS16470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI317_RS16485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI317_RS16495	COG0643	Histidine kinase
BI317_RS16495	COG2198	Histidine kinase
BI317_RS16500	COG0840	transmembrane signaling receptor activity
BI317_RS16505	COG0835	chemotaxis
BI317_RS16515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI317_RS16525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI317_RS16530	COG3590	peptidase
BI317_RS16545	COG1515	deoxyribonuclease V activity
BI317_RS16550	COG1741	Belongs to the pirin family
BI317_RS16565	COG1741	Belongs to the pirin family
BI317_RS16570	COG1966	Carbon starvation protein
BI317_RS16575	COG2879	small protein
BI317_RS16590	COG4191	Histidine kinase
BI317_RS16590	COG0784	Response regulator, receiver
BI317_RS16595	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI317_RS16600	COG5002	protein histidine kinase activity
BI317_RS16600	COG2205	protein histidine kinase activity
BI317_RS16600	COG0784	Response regulator, receiver
BI317_RS16620	COG0840	transmembrane signaling receptor activity
BI317_RS16745	COG2003	Belongs to the UPF0758 family
BI317_RS16790	COG0758	DNA mediated transformation
BI317_RS16850	COG2815	serine threonine protein kinase
BI317_RS16850	COG0515	serine threonine protein kinase
BI317_RS16915	COG0210	DNA helicase
BI317_RS16920	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI317_RS16950	COG0583	DNA-binding transcription factor activity
BI317_RS16965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI317_RS16980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI317_RS16985	COG0077	Prephenate dehydratase
BI317_RS16985	COG1605	Chorismate mutase
BI317_RS16990	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI317_RS16995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI317_RS17000	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI317_RS17035	COG1228	amidohydrolase
BI317_RS17040	COG2986	histidine ammonia-lyase
BI317_RS17050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI317_RS17060	COG0477	Major facilitator Superfamily
BI317_RS17090	COG0784	Response regulator, receiver
BI317_RS17090	COG2198	Histidine kinase
BI317_RS17090	COG2205	protein histidine kinase activity
BI317_RS17095	COG2353	YceI-like domain
BI317_RS17100	COG3038	cytochrome b561
BI317_RS17110	COG1278	Cold shock
BI317_RS17120	COG1760	l-serine dehydratase
BI317_RS17130	COG0527	aspartate kinase activity
BI317_RS17130	COG0460	homoserine dehydrogenase
BI317_RS17135	COG0626	cystathionine gamma-synthase activity
BI317_RS17140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI317_RS17150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI317_RS17155	COG1272	protein, Hemolysin III
BI317_RS17160	COG2982	Protein involved in outer membrane biogenesis
BI317_RS17170	COG0516	GMP reductase activity
BI317_RS17170	COG0517	IMP dehydrogenase activity
BI317_RS17175	COG0463	Glycosyl transferase, family 2
BI317_RS17180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI317_RS17185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI317_RS17195	COG4206	TonB-dependent receptor
BI317_RS17200	COG1309	transcriptional regulator
BI317_RS17210	COG1960	acyl-CoA dehydrogenase activity
BI317_RS17245	COG0509	glycine decarboxylation via glycine cleavage system
BI317_RS17250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI317_RS17255	COG1742	UPF0060 membrane protein
BI317_RS17260	COG3956	TIGRFAM MazG family protein
BI317_RS17265	COG1218	3'(2'),5'-bisphosphate nucleotidase
BI317_RS17270	COG0494	nUDIX hydrolase
BI317_RS17280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI317_RS17300	COG3858	chitin binding
BI317_RS17300	COG1388	LysM domain
BI317_RS17320	COG1472	Belongs to the glycosyl hydrolase 3 family
BI317_RS17345	COG0531	amino acid
BI317_RS17355	COG1486	melibiose metabolic process
BI317_RS17365	COG3537	Alpha-1,2-mannosidase
BI317_RS17455	COG3142	Participates in the control of copper homeostasis
BI317_RS17460	COG1446	asparaginase
BI317_RS17465	COG2304	oxidoreductase activity
BI317_RS17470	COG1595	DNA-templated transcription, initiation
BI317_RS17495	COG2201	protein-glutamate methylesterase activity
BI317_RS17500	COG2198	Histidine kinase
BI317_RS17500	COG0643	Histidine kinase
BI317_RS17500	COG0784	Response regulator, receiver
BI317_RS17505	COG0840	transmembrane signaling receptor activity
BI317_RS17510	COG0835	chemotaxis
BI317_RS17525	COG0189	ligase activity
BI317_RS17540	COG1199	ATP-dependent helicase activity
BI317_RS17550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI317_RS17565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI317_RS17575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI317_RS17580	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BI317_RS17600	COG0837	glucose binding
BI317_RS17610	COG1643	Atp-dependent helicase
BI317_RS17615	COG0783	Belongs to the Dps family
BI317_RS17620	COG0514	ATP-dependent DNA helicase (RecQ)
BI317_RS17635	COG1187	pseudouridine synthase activity
BI317_RS17670	COG3920	Histidine kinase
BI317_RS17675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI317_RS17715	COG0667	Aldo Keto reductase
BI317_RS17720	COG0602	queuosine metabolic process
BI317_RS17730	COG2885	chlorophyll binding
BI317_RS17745	COG0848	biopolymer transport protein
BI317_RS17755	COG0824	Thioesterase
BI317_RS17760	COG2255	four-way junction helicase activity
BI317_RS17805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI317_RS17825	COG0477	Major facilitator Superfamily
BI317_RS17865	COG0488	(ABC) transporter
BI317_RS17895	COG4651	solute:proton antiporter activity
BI317_RS17895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI317_RS17905	COG4772	TonB-dependent receptor
BI317_RS17915	COG4264	IucA IucC family
BI317_RS17925	COG4264	IucA IucC family
BI317_RS17930	COG0019	diaminopimelate decarboxylase activity
BI317_RS17945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI317_RS17955	COG4206	TonB-dependent receptor
BI317_RS17965	COG0542	response to heat
BI317_RS17970	COG1116	anion transmembrane transporter activity
BI317_RS17975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI317_RS17980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI317_RS17985	COG0667	Aldo Keto reductase
BI317_RS17995	COG4771	TonB-dependent receptor
BI317_RS18045	COG1877	trehalose-phosphatase activity
BI317_RS18050	COG3387	PFAM Glycoside hydrolase 15-related
BI317_RS18065	COG0840	transmembrane signaling receptor activity
BI317_RS18070	COG3011	Protein conserved in bacteria
BI317_RS18085	COG0564	pseudouridine synthase activity
BI317_RS18090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI317_RS18100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI317_RS18100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI317_RS18135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI317_RS18140	COG0045	succinate-CoA ligase (ADP-forming) activity
BI317_RS18170	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI317_RS18200	COG0745	RESPONSE REGULATOR receiver
BI317_RS18205	COG0189	ligase activity
BI317_RS18240	COG0840	transmembrane signaling receptor activity
BI317_RS18245	COG1238	metal cluster binding
BI317_RS18340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BI317_RS18505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI317_RS18530	COG3077	Addiction module antitoxin, RelB DinJ family
BI317_RS18560	COG0583	DNA-binding transcription factor activity
BI317_RS18565	COG1396	sequence-specific DNA binding
BI317_RS18635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BI317_RS18640	COG0471	metal ion transport
BI317_RS18640	COG3273	potassium ion transport
BI317_RS18670	COG1609	Transcriptional regulator
BI317_RS18680	COG3250	beta-galactosidase activity
BI317_RS18685	COG4948	Mandelate Racemase Muconate Lactonizing
BI317_RS18695	COG2272	Belongs to the type-B carboxylesterase lipase family
BI317_RS18700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI317_RS18720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI317_RS18725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI317_RS18730	COG0529	Catalyzes the synthesis of activated sulfate
BI317_RS18730	COG2895	sulfate adenylyltransferase (ATP) activity
BI317_RS18745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI317_RS18750	COG0175	sulfate reduction
BI317_RS18770	COG2205	protein histidine kinase activity
BI317_RS18770	COG0784	Response regulator, receiver
BI317_RS18770	COG2198	Histidine kinase
BI317_RS18785	COG1648	precorrin-2 dehydrogenase activity
BI317_RS18785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI317_RS18800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BI317_RS18805	COG3588	fructose-bisphosphate aldolase
BI317_RS18815	COG0469	pyruvate kinase activity
BI317_RS18845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI317_RS18860	COG3047	cAMP biosynthetic process
BI317_RS18870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI317_RS18870	COG3453	Protein conserved in bacteria
BI317_RS18875	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI317_RS18880	COG4149	molybdate abc transporter
BI317_RS18885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI317_RS18900	COG3682	Transcriptional regulator
BI317_RS18920	COG1376	ErfK ybiS ycfS ynhG family protein
BI317_RS18935	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS18940	COG0583	DNA-binding transcription factor activity
BI317_RS18945	COG4773	Receptor
BI317_RS18960	COG1301	dicarboxylic acid transport
BI317_RS18995	COG0714	Associated with various cellular activities
BI317_RS19025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BI317_RS19050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI317_RS19060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI317_RS19075	COG1561	YicC-like family, N-terminal region
BI317_RS19080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI317_RS19085	COG0346	lactoylglutathione lyase activity
BI317_RS19095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI317_RS19110	COG0006	proline dipeptidase activity
BI317_RS19115	COG0006	proline dipeptidase activity
BI317_RS19140	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI317_RS19160	COG2912	Transglutaminase-like superfamily
BI317_RS19165	COG1773	rubredoxin
BI317_RS19170	COG0352	thiamine-phosphate diphosphorylase activity
BI317_RS19185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI317_RS19195	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BI317_RS19200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI317_RS19230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI317_RS19235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI317_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS19265	COG0671	phosphoesterase, PA-phosphatase related
BI317_RS19275	COG3781	membrane
BI317_RS19285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI317_RS19290	COG0563	adenylate kinase activity
BI317_RS19310	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BI317_RS19320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI317_RS19340	COG3710	Transcriptional regulator
BI317_RS19345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BI317_RS19355	COG0823	Involved in the tonB-independent uptake of proteins
BI317_RS19355	COG1506	peptidase
BI317_RS19355	COG4946	Tricorn protease homolog
BI317_RS19360	COG0840	transmembrane signaling receptor activity
BI317_RS19370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI317_RS19390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI317_RS19395	COG0473	3-isopropylmalate dehydrogenase activity
BI317_RS19400	COG2226	methyltransferase
BI317_RS19405	COG0066	3-isopropylmalate dehydratase activity
BI317_RS19410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI317_RS19430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI317_RS19435	COG1538	Outer membrane efflux protein
BI317_RS19445	COG1519	Transferase
BI317_RS19450	COG1560	Kdo2-lipid A biosynthetic process
BI317_RS19475	COG0280	phosphate acetyltransferase
BI317_RS19475	COG0281	malic enzyme
BI317_RS19490	COG4191	Histidine kinase
BI317_RS19505	COG2197	response regulator
BI317_RS19515	COG0642	Histidine kinase
BI317_RS19530	COG2851	Citrate transporter
BI317_RS19535	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS19540	COG1609	Transcriptional regulator
BI317_RS19545	COG2211	Major facilitator Superfamily
BI317_RS19675	COG4773	Receptor
BI317_RS19680	COG0726	polysaccharide deacetylase
BI317_RS19685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI317_RS19705	COG0402	S-adenosylhomocysteine deaminase activity
BI317_RS19765	COG0697	spore germination
BI317_RS19775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI317_RS19815	COG0745	RESPONSE REGULATOR receiver
BI317_RS19820	COG2205	protein histidine kinase activity
BI317_RS19830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI317_RS19845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI317_RS19855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI317_RS19865	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI317_RS19905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI317_RS19910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI317_RS19915	COG1609	Transcriptional regulator
BI317_RS19925	COG2188	Transcriptional regulator
BI317_RS19940	COG3250	beta-galactosidase activity
BI317_RS19965	COG3156	type II secretion system protein K
BI317_RS19990	COG1459	type II secretion system
BI317_RS20040	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS20045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI317_RS20050	COG4191	Histidine kinase
BI317_RS20055	COG0784	Response regulator, receiver
BI317_RS20060	COG4251	negative regulation of phosphorylation
BI317_RS20065	COG2823	Periplasmic or secreted lipoprotein
BI317_RS20070	COG0673	inositol 2-dehydrogenase activity
BI317_RS20075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BI317_RS20110	COG1051	belongs to the nudix hydrolase family
BI317_RS20110	COG1056	cytidyltransferase-related domain
BI317_RS20130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI317_RS20135	COG0321	lipoyl(octanoyl) transferase activity
BI317_RS20150	COG1686	Belongs to the peptidase S11 family
BI317_RS20155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI317_RS20160	COG2951	lytic endotransglycosylase activity
BI317_RS20170	COG0772	Belongs to the SEDS family
BI317_RS20180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BI317_RS20185	COG1792	Involved in formation and maintenance of cell shape
BI317_RS20190	COG1077	Cell shape determining protein MreB Mrl
BI317_RS20195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI317_RS20200	COG3284	Transcriptional regulator
BI317_RS20255	COG0308	aminopeptidase N
BI317_RS20260	COG3300	MHYT domain
BI317_RS20260	COG5001	Diguanylate cyclase
BI317_RS20265	COG2226	methyltransferase
BI317_RS20295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI317_RS20300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI317_RS20305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI317_RS20310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI317_RS20320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI317_RS20330	COG2832	Protein of unknown function (DUF454)
BI317_RS20365	COG1505	serine-type exopeptidase activity
BI317_RS20390	COG0181	hydroxymethylbilane synthase activity
BI317_RS20400	COG3275	phosphorelay sensor kinase activity
BI317_RS20435	COG3706	GGDEF domain
BI317_RS20440	COG0659	secondary active sulfate transmembrane transporter activity
BI317_RS20445	COG5297	Belongs to the glycosyl hydrolase family 6
BI317_RS20445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI317_RS20515	COG3507	Belongs to the glycosyl hydrolase 43 family
BI317_RS20530	COG1113	amino acid transport
BI317_RS20550	COG0697	spore germination
BI317_RS20575	COG3706	GGDEF domain
BI317_RS20620	COG0435	Glutathione S-transferase
BI317_RS20750	COG0210	DNA helicase
BI317_RS20845	COG1802	Transcriptional regulator
BI317_RS20880	COG3052	prosthetic group binding
BI317_RS20905	COG2353	YceI-like domain
BI317_RS20930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI317_RS20935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI317_RS20965	COG3712	iron ion homeostasis
BI317_RS21000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI317_RS21005	COG3550	peptidyl-serine autophosphorylation
BI317_RS21055	COG2356	endonuclease I
BI317_RS21060	COG1324	tolerance protein
BI317_RS21070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI317_RS21075	COG0511	ligase activity, forming carbon-carbon bonds
BI317_RS21085	COG0439	Biotin carboxylase
BI317_RS21100	COG2264	protein methyltransferase activity
BI317_RS21125	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI317_RS21160	COG0138	bifunctional purine biosynthesis protein purh
BI317_RS21165	COG0151	Belongs to the GarS family
BI317_RS21170	COG1289	transmembrane transporter activity
BI317_RS21175	COG2814	Major facilitator Superfamily
BI317_RS21195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI317_RS21200	COG2816	NAD+ diphosphatase activity
BI317_RS21210	COG0316	Belongs to the HesB IscA family
BI317_RS21275	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI317_RS21290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI317_RS21300	COG0134	indole-3-glycerol-phosphate synthase activity
BI317_RS21305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI317_RS21320	COG0840	transmembrane signaling receptor activity
BI317_RS21345	COG3550	peptidyl-serine autophosphorylation
BI317_RS21350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI317_RS21430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI317_RS21515	COG2267	carboxylic ester hydrolase activity
BI317_RS21555	COG1597	lipid kinase activity
BI317_RS21575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI317_RS21640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI317_RS21640	COG2111	Na H antiporter
BI317_RS21645	COG1006	Multisubunit Na H antiporter MnhC subunit
BI317_RS21650	COG0651	ATP synthesis coupled electron transport
BI317_RS21660	COG2212	antiporter activity
BI317_RS21665	COG1320	monovalent cation:proton antiporter activity
BI317_RS21685	COG2852	Protein conserved in bacteria
BI317_RS21705	COG3104	oligopeptide transport
BI317_RS21720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI317_RS21735	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI317_RS21745	COG0513	Belongs to the DEAD box helicase family
BI317_RS21755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI317_RS21795	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS21800	COG0702	epimerase
BI317_RS21825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI317_RS21830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI317_RS21835	COG0297	glycogen (starch) synthase activity
BI317_RS21850	COG2354	Protein conserved in bacteria
BI317_RS21855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI317_RS21860	COG1368	sulfuric ester hydrolase activity
BI317_RS21870	COG1511	domain protein
BI317_RS21870	COG3264	Mechanosensitive ion channel
BI317_RS21890	COG3590	peptidase
BI317_RS21930	COG1040	competence protein
BI317_RS21935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI317_RS21940	COG0156	8-amino-7-oxononanoate synthase activity
BI317_RS22010	COG1414	Transcriptional regulator
BI317_RS22020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI317_RS22025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI317_RS22040	COG3485	protocatechuate 3,4-dioxygenase
BI317_RS22050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI317_RS22055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI317_RS22085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI317_RS22090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI317_RS22145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI317_RS22155	COG0129	dihydroxy-acid dehydratase activity
BI317_RS22270	COG1733	regulation of RNA biosynthetic process
BI317_RS22275	COG0702	epimerase
BI317_RS22305	COG0583	DNA-binding transcription factor activity
BI317_RS22310	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI317_RS22315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI317_RS22350	COG1902	pentaerythritol trinitrate reductase activity
BI317_RS22355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI317_RS22390	COG2814	Major facilitator Superfamily
BI317_RS22395	COG0583	DNA-binding transcription factor activity
BI317_RS22410	COG0084	hydrolase, TatD family'
BI317_RS22430	COG2252	PERMEase
BI317_RS22680	COG4695	Portal protein
BI317_RS22750	COG1074	ATP-dependent DNA helicase activity
BI317_RS22755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI317_RS22755	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BI317_RS22765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI317_RS22765	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BI317_RS22785	COG1487	ribonuclease activity
BI317_RS22790	COG1902	pentaerythritol trinitrate reductase activity
BI317_RS22795	COG0583	DNA-binding transcription factor activity
BI317_RS22800	COG1309	transcriptional regulator
BI317_RS22815	COG4977	sequence-specific DNA binding
BI317_RS22835	COG0659	secondary active sulfate transmembrane transporter activity
BI317_RS22865	COG0251	oxidation-reduction process
BI317_RS22880	COG1131	(ABC) transporter
BI317_RS22920	COG2814	Major facilitator Superfamily
BI317_RS22925	COG0583	DNA-binding transcription factor activity
BI317_RS22945	COG1063	alcohol dehydrogenase
BI317_RS22960	COG1132	(ABC) transporter
BI317_RS22980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BI317_RS23000	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS23015	COG2204	response regulator
BI317_RS23045	COG3546	catalase activity
BI317_RS23050	COG3685	Protein conserved in bacteria
BI317_RS23070	COG2972	Histidine kinase
BI317_RS23085	COG0531	amino acid
BI317_RS23110	COG3590	peptidase
BI317_RS23120	COG0667	Aldo Keto reductase
BI317_RS23130	COG0583	DNA-binding transcription factor activity
BI317_RS23140	COG3384	dioxygenase
BI317_RS23155	COG1573	uracil-dna glycosylase
BI317_RS23160	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI317_RS23175	COG0025	NhaP-type Na H and K H
BI317_RS23180	COG1131	(ABC) transporter
BI317_RS23185	COG0842	Transport permease protein
BI317_RS23225	COG0596	Alpha beta hydrolase
BI317_RS23250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI317_RS23270	COG2072	flavoprotein involved in K transport
BI317_RS23275	COG2351	hydroxyisourate hydrolase activity
BI317_RS23280	COG4807	Protein conserved in bacteria
BI317_RS23290	COG0840	transmembrane signaling receptor activity
BI317_RS23295	COG1643	Atp-dependent helicase
BI317_RS23310	COG1187	pseudouridine synthase activity
BI317_RS23325	COG2130	NADP-dependent
BI317_RS23330	COG0656	L-ascorbic acid biosynthetic process
BI317_RS23355	COG1764	response to oxidative stress
BI317_RS23360	COG1846	Transcriptional regulator
BI317_RS23375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI317_RS23385	COG0697	spore germination
BI317_RS23400	COG0523	cobalamin synthesis protein
BI317_RS23455	COG1960	acyl-CoA dehydrogenase activity
BI317_RS23460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI317_RS23465	COG4770	biotin carboxylase activity
BI317_RS23490	COG5001	Diguanylate cyclase
BI317_RS23495	COG2224	Isocitrate lyase
BI317_RS23500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI317_RS23505	COG0583	DNA-binding transcription factor activity
BI317_RS23525	COG0339	signal peptide processing
BI317_RS23530	COG1446	asparaginase
BI317_RS23550	COG0564	pseudouridine synthase activity
BI317_RS23565	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI317_RS23575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI317_RS23595	COG0318	PFAM AMP-dependent synthetase and ligase
BI317_RS23600	COG0727	PFAM Uncharacterised protein family (UPF0153)
BI317_RS23605	COG0596	Alpha beta hydrolase
BI317_RS23610	COG3177	Filamentation induced by cAMP protein fic
BI317_RS23615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI317_RS23630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI317_RS23660	COG0028	Belongs to the TPP enzyme family
BI317_RS23670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI317_RS23680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI317_RS23720	COG0183	Belongs to the thiolase family
BI317_RS23730	COG2032	superoxide dismutase activity
BI317_RS23735	COG2032	superoxide dismutase activity
BI317_RS23740	COG2204	response regulator
BI317_RS23745	COG3852	Histidine kinase
BI317_RS23750	COG0004	ammonium transporteR
BI317_RS23755	COG0347	Belongs to the P(II) protein family
BI317_RS23760	COG0174	glutamine synthetase
BI317_RS23775	COG1881	PFAM PEBP family protein
BI317_RS23810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI317_RS23820	COG2062	phosphohistidine phosphatase, SixA
BI317_RS23825	COG0489	protein tyrosine kinase activity
BI317_RS23850	COG1396	sequence-specific DNA binding
BI317_RS23855	COG3550	peptidyl-serine autophosphorylation
BI317_RS23865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI317_RS23880	COG1125	glycine betaine transport
BI317_RS23880	COG0517	IMP dehydrogenase activity
BI317_RS23895	COG1119	ATPase activity
BI317_RS23900	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI317_RS23910	COG1522	sequence-specific DNA binding
BI317_RS23915	COG3186	Phenylalanine-4-hydroxylase
BI317_RS23935	COG2755	lipolytic protein G-D-S-L family
BI317_RS23945	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS23950	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI317_RS23960	COG1609	Transcriptional regulator
BI317_RS23965	COG3507	Belongs to the glycosyl hydrolase 43 family
BI317_RS23980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI317_RS24000	COG2755	lipolytic protein G-D-S-L family
BI317_RS24030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI317_RS24035	COG0366	Alpha amylase catalytic
BI317_RS24040	COG0366	Alpha amylase catalytic
BI317_RS24180	COG2207	Transcriptional regulator
BI317_RS24185	COG1028	Short-chain dehydrogenase reductase Sdr
BI317_RS24195	COG3549	Plasmid maintenance system killer
BI317_RS24280	COG4232	protein-disulfide reductase activity
BI317_RS24285	COG0210	DNA helicase
BI317_RS24365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI317_RS24400	COG4644	lycopene metabolic process
BI317_RS24445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BI317_RS24450	COG0431	NADPH-dependent FMN reductase
BI317_RS24455	COG1393	Belongs to the ArsC family
BI317_RS24460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI317_RS24475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI317_RS24500	COG2132	Multicopper oxidase
BI317_RS24555	COG0010	Belongs to the arginase family
BI317_RS24570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI317_RS24980	COG1199	ATP-dependent helicase activity
BI317_RS24990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BI317_RS25000	COG0745	RESPONSE REGULATOR receiver
BI317_RS25135	COG1475	DNA binding
BI317_RS25170	COG0629	single-stranded DNA binding
BI317_RS25200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI317_RS25270	COG0653	protein targeting
BI317_RS25375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI317_RS25520	COG3328	transposase activity
BI317_RS25675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI317_RS25870	COG4962	Type ii secretion system protein e
BI317_RS26170	COG5484	DNA packaging
BI317_RS26170	COG3728	DNA packaging
BI317_RS26310	COG1525	nuclease
BI317_RS27095	COG2977	Belongs to the P-Pant transferase superfamily
BI317_RS27265	COG0582	viral genome integration into host DNA
BI317_RS27290	COG5599	Phosphatase