locus-tag	class	description
FZ025_RS00010	COG0668	transmembrane transport
FZ025_RS00020	COG0590	tRNA wobble adenosine to inosine editing
FZ025_RS00025	COG1321	iron dependent repressor
FZ025_RS00030	COG1914	H( )-stimulated, divalent metal cation uptake system
FZ025_RS00040	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FZ025_RS00045	COG0166	Belongs to the GPI family
FZ025_RS00060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FZ025_RS00070	COG0617	tRNA 3'-terminal CCA addition
FZ025_RS00080	COG0860	N-Acetylmuramoyl-L-alanine amidase
FZ025_RS00085	COG0477	Major facilitator Superfamily
FZ025_RS00090	COG2115	Belongs to the xylose isomerase family
FZ025_RS00095	COG1070	Carbohydrate kinase
FZ025_RS00105	COG1501	Belongs to the glycosyl hydrolase 31 family
FZ025_RS00125	COG0800	Aldolase
FZ025_RS00140	COG3734	2-keto-3-deoxy-galactonokinase
FZ025_RS00145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FZ025_RS00150	COG0287	Prephenate dehydrogenase
FZ025_RS00150	COG1605	Chorismate mutase
FZ025_RS00155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FZ025_RS00160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FZ025_RS00165	COG2867	negative regulation of translational initiation
FZ025_RS00175	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FZ025_RS00180	COG0735	belongs to the Fur family
FZ025_RS00185	COG0497	DNA recombination
FZ025_RS00190	COG1420	regulation of RNA biosynthetic process
FZ025_RS00195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FZ025_RS00200	COG0443	Heat shock 70 kDa protein
FZ025_RS00205	COG0484	heat shock protein binding
FZ025_RS00230	COG0531	amino acid
FZ025_RS00235	COG0531	amino acid
FZ025_RS00240	COG0235	Class ii aldolase
FZ025_RS00245	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FZ025_RS00250	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FZ025_RS00265	COG0140	phosphoribosyl-ATP diphosphatase activity
FZ025_RS00265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FZ025_RS00280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FZ025_RS00295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FZ025_RS00300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FZ025_RS00310	COG0124	histidyl-tRNA synthetase
FZ025_RS00315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FZ025_RS00325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FZ025_RS00330	COG0083	homoserine kinase activity
FZ025_RS00335	COG0460	homoserine dehydrogenase
FZ025_RS00335	COG0527	aspartate kinase activity
FZ025_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
FZ025_RS00365	COG0167	dihydroorotate dehydrogenase activity
FZ025_RS00370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FZ025_RS00380	COG1794	racemase activity, acting on amino acids and derivatives
FZ025_RS00385	COG0671	phosphoesterase, PA-phosphatase related
FZ025_RS00400	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FZ025_RS00410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FZ025_RS00495	COG3702	type iv secretory pathway
FZ025_RS00560	COG0556	nucleotide-excision repair
FZ025_RS00710	COG1611	Belongs to the LOG family
FZ025_RS00725	COG2095	MarC family integral membrane protein
FZ025_RS00735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FZ025_RS00775	COG2969	positive regulation of protein catabolic process
FZ025_RS00780	COG0625	glutathione transferase activity
FZ025_RS00785	COG2857	Cytochrome c1
FZ025_RS00790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FZ025_RS00795	COG0723	plastoquinol--plastocyanin reductase activity
FZ025_RS00800	COG0741	lytic transglycosylase activity
FZ025_RS00825	COG1702	phosphate starvation-inducible protein PhoH
FZ025_RS00830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FZ025_RS00840	COG4535	Mg2 and Co2 transporter CorC
FZ025_RS00855	COG1012	belongs to the aldehyde dehydrogenase family
FZ025_RS00860	COG1177	transmembrane transport
FZ025_RS00865	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZ025_RS00870	COG3842	ATPase activity
FZ025_RS00895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FZ025_RS00900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FZ025_RS00910	COG0174	glutamine synthetase
FZ025_RS00915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FZ025_RS00920	COG0174	glutamine synthetase
FZ025_RS00925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZ025_RS00930	COG0477	Major facilitator Superfamily
FZ025_RS00985	COG1012	belongs to the aldehyde dehydrogenase family
FZ025_RS00990	COG1917	Cupin 2, conserved barrel domain protein
FZ025_RS00990	COG1396	sequence-specific DNA binding
FZ025_RS01005	COG0686	Belongs to the AlaDH PNT family
FZ025_RS01025	COG2733	membrane
FZ025_RS01030	COG2205	protein histidine kinase activity
FZ025_RS01030	COG0784	Response regulator, receiver
FZ025_RS01030	COG5002	protein histidine kinase activity
FZ025_RS01075	COG0494	nUDIX hydrolase
FZ025_RS01085	COG1024	Enoyl-CoA hydratase
FZ025_RS01095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FZ025_RS01100	COG0659	secondary active sulfate transmembrane transporter activity
FZ025_RS01120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FZ025_RS01125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FZ025_RS01130	COG0573	inorganic phosphate transmembrane transporter activity
FZ025_RS01135	COG0581	inorganic phosphate transmembrane transporter activity
FZ025_RS01145	COG0704	Plays a role in the regulation of phosphate uptake
FZ025_RS01170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FZ025_RS01195	COG3039	Transposase
FZ025_RS01200	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS01220	COG3668	Plasmid stabilization system
FZ025_RS01225	COG3706	GGDEF domain
FZ025_RS01225	COG0745	RESPONSE REGULATOR receiver
FZ025_RS01230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FZ025_RS01240	COG0557	exoribonuclease II activity
FZ025_RS01305	COG2977	Belongs to the P-Pant transferase superfamily
FZ025_RS01320	COG2822	iron ion transport
FZ025_RS01330	COG0477	Major facilitator Superfamily
FZ025_RS01340	COG4372	Transposase
FZ025_RS01355	COG0583	DNA-binding transcription factor activity
FZ025_RS01380	COG1605	Chorismate mutase
FZ025_RS01380	COG0077	Prephenate dehydratase
FZ025_RS01385	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FZ025_RS01390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FZ025_RS01395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FZ025_RS01430	COG4221	oxidoreductase activity
FZ025_RS01460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FZ025_RS01535	COG0069	glutamate synthase activity
FZ025_RS01540	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FZ025_RS01550	COG1609	Transcriptional regulator
FZ025_RS01555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FZ025_RS01555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FZ025_RS01560	COG1105	Belongs to the carbohydrate kinase PfkB family
FZ025_RS01565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FZ025_RS01565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FZ025_RS01580	COG0745	RESPONSE REGULATOR receiver
FZ025_RS01600	COG1136	(ABC) transporter
FZ025_RS01600	COG0577	efflux transmembrane transporter activity
FZ025_RS01640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FZ025_RS01655	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
FZ025_RS01660	COG0583	DNA-binding transcription factor activity
FZ025_RS01665	COG0604	alcohol dehydrogenase
FZ025_RS01670	COG0596	Alpha beta hydrolase
FZ025_RS01690	COG1335	isochorismatase
FZ025_RS01720	COG1733	regulation of RNA biosynthetic process
FZ025_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS01760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FZ025_RS01770	COG0348	domain, Protein
FZ025_RS01820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FZ025_RS01835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FZ025_RS01840	COG3291	Pkd domain containing protein
FZ025_RS01845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZ025_RS01850	COG0405	Gamma-glutamyltransferase
FZ025_RS01855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FZ025_RS01885	COG0717	Belongs to the dCTP deaminase family
FZ025_RS01890	COG0489	protein tyrosine kinase activity
FZ025_RS01900	COG4771	TonB-dependent receptor
FZ025_RS01920	COG0514	ATP-dependent DNA helicase (RecQ)
FZ025_RS01950	COG0602	queuosine metabolic process
FZ025_RS01960	COG2885	chlorophyll binding
FZ025_RS01965	COG0823	Involved in the tonB-independent uptake of proteins
FZ025_RS01975	COG0848	biopolymer transport protein
FZ025_RS01985	COG0824	Thioesterase
FZ025_RS01990	COG2255	four-way junction helicase activity
FZ025_RS02000	COG0632	four-way junction helicase activity
FZ025_RS02010	COG0217	transcriptional regulatory protein
FZ025_RS02025	COG2207	Transcriptional regulator
FZ025_RS02035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FZ025_RS02070	COG0488	(ABC) transporter
FZ025_RS02125	COG4651	solute:proton antiporter activity
FZ025_RS02125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FZ025_RS02135	COG4772	TonB-dependent receptor
FZ025_RS02145	COG4264	IucA IucC family
FZ025_RS02150	COG2814	Major facilitator Superfamily
FZ025_RS02155	COG4264	IucA IucC family
FZ025_RS02160	COG0019	diaminopimelate decarboxylase activity
FZ025_RS02165	COG2223	nitrite transmembrane transporter activity
FZ025_RS02200	COG0542	response to heat
FZ025_RS02220	COG0454	-acetyltransferase
FZ025_RS02260	COG0742	ribosomal rna small subunit methyltransferase
FZ025_RS02265	COG0326	Molecular chaperone. Has ATPase activity
FZ025_RS02275	COG3345	alpha-galactosidase
FZ025_RS02285	COG4771	TonB-dependent receptor
FZ025_RS02295	COG3507	Belongs to the glycosyl hydrolase 43 family
FZ025_RS02305	COG4206	TonB-dependent receptor
FZ025_RS02330	COG0531	amino acid
FZ025_RS02345	COG0006	proline dipeptidase activity
FZ025_RS02355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZ025_RS02370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZ025_RS02375	COG3938	Belongs to the proline racemase family
FZ025_RS02385	COG0552	protein localization to endoplasmic reticulum
FZ025_RS02390	COG1194	a g-specific adenine glycosylase
FZ025_RS02470	COG3300	MHYT domain
FZ025_RS02470	COG5001	Diguanylate cyclase
FZ025_RS02475	COG1185	polyribonucleotide nucleotidyltransferase activity
FZ025_RS02485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FZ025_RS02500	COG0195	Participates in both transcription termination and antitermination
FZ025_RS02515	COG1007	ATP synthesis coupled electron transport
FZ025_RS02555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FZ025_RS02560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FZ025_RS02570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FZ025_RS02580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FZ025_RS02595	COG0149	triose-phosphate isomerase activity
FZ025_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS02615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FZ025_RS02645	COG0101	tRNA pseudouridine synthase activity
FZ025_RS02680	COG2890	protein-(glutamine-N5) methyltransferase activity
FZ025_RS02690	COG0688	phosphatidylethanolamine metabolic process
FZ025_RS02700	COG0741	lytic transglycosylase activity
FZ025_RS02705	COG0433	COG0433 Predicted ATPase
FZ025_RS02715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FZ025_RS02730	COG0629	single-stranded DNA binding
FZ025_RS02735	COG0142	geranyltranstransferase activity
FZ025_RS02755	COG0527	aspartate kinase activity
FZ025_RS02760	COG0384	phenazine biosynthesis protein PhzF
FZ025_RS02770	COG1764	response to oxidative stress
FZ025_RS02815	COG0719	Fe-S assembly protein
FZ025_RS02820	COG0396	ATPase activity
FZ025_RS02825	COG0719	Fe-S assembly protein
FZ025_RS02830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FZ025_RS02840	COG2146	nitrite reductase [NAD(P)H] activity
FZ025_RS02845	COG4774	siderophore transport
FZ025_RS02870	COG1477	protein flavinylation
FZ025_RS02875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FZ025_RS02910	COG1555	photosystem II stabilization
FZ025_RS02925	COG3178	'Phosphotransferase
FZ025_RS02930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FZ025_RS02935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FZ025_RS02940	COG0628	permease
FZ025_RS02965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FZ025_RS03000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FZ025_RS03015	COG1137	ATPase activity
FZ025_RS03030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FZ025_RS03040	COG1660	Displays ATPase and GTPase activities
FZ025_RS03050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FZ025_RS03055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FZ025_RS03060	COG2239	Acts as a magnesium transporter
FZ025_RS03075	COG1113	amino acid transport
FZ025_RS03080	COG0840	transmembrane signaling receptor activity
FZ025_RS03120	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS03140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FZ025_RS03155	COG0519	Catalyzes the synthesis of GMP from XMP
FZ025_RS03180	COG1192	Involved in chromosome partitioning
FZ025_RS03195	COG4959	Type IV secretory pathway protease TraF
FZ025_RS03215	COG1566	PFAM secretion protein HlyD family protein
FZ025_RS03220	COG2814	Major facilitator Superfamily
FZ025_RS03310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FZ025_RS03335	COG0754	glutathionylspermidine amidase activity
FZ025_RS03340	COG5463	Belongs to the UPF0441 family
FZ025_RS03360	COG1842	Phage shock protein A
FZ025_RS03400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FZ025_RS03405	COG2814	Major facilitator Superfamily
FZ025_RS03425	COG3038	cytochrome b561
FZ025_RS03445	COG1760	l-serine dehydratase
FZ025_RS03450	COG3706	GGDEF domain
FZ025_RS03460	COG0527	aspartate kinase activity
FZ025_RS03460	COG0460	homoserine dehydrogenase
FZ025_RS03465	COG0626	cystathionine gamma-synthase activity
FZ025_RS03470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZ025_RS03475	COG0739	heme binding
FZ025_RS03480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FZ025_RS03485	COG1272	protein, Hemolysin III
FZ025_RS03490	COG2982	Protein involved in outer membrane biogenesis
FZ025_RS03495	COG0517	IMP dehydrogenase activity
FZ025_RS03500	COG0463	Glycosyl transferase, family 2
FZ025_RS03505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FZ025_RS03510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FZ025_RS03540	COG1960	acyl-CoA dehydrogenase activity
FZ025_RS03575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FZ025_RS03580	COG1216	Glycosyl transferase, family 2
FZ025_RS03590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FZ025_RS03630	COG3279	Response regulator of the LytR AlgR family
FZ025_RS03635	COG3275	phosphorelay sensor kinase activity
FZ025_RS03650	COG1643	Atp-dependent helicase
FZ025_RS03655	COG0783	Belongs to the Dps family
FZ025_RS03665	COG0039	L-malate dehydrogenase activity
FZ025_RS03675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FZ025_RS03700	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FZ025_RS03710	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FZ025_RS03715	COG0203	ribosomal protein L17
FZ025_RS03720	COG0202	RNA polymerase activity
FZ025_RS03725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FZ025_RS03730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FZ025_RS03735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FZ025_RS03740	COG0201	protein transport
FZ025_RS03750	COG1841	ribosomal large subunit assembly
FZ025_RS03755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FZ025_RS03775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FZ025_RS03780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FZ025_RS03785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FZ025_RS03790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FZ025_RS03795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FZ025_RS03800	COG0255	Belongs to the universal ribosomal protein uL29 family
FZ025_RS03815	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FZ025_RS03825	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FZ025_RS03830	COG0089	rRNA binding
FZ025_RS03845	COG0051	transcription antitermination factor activity, RNA binding
FZ025_RS03850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FZ025_RS03855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FZ025_RS03870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FZ025_RS03880	COG0222	ribosome binding
FZ025_RS03895	COG0081	regulation of translation
FZ025_RS03900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FZ025_RS03905	COG0250	Participates in transcription elongation, termination and antitermination
FZ025_RS03910	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FZ025_RS03920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FZ025_RS03940	COG0012	GTP binding
FZ025_RS03945	COG0193	aminoacyl-tRNA hydrolase activity
FZ025_RS03955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FZ025_RS03980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FZ025_RS03985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FZ025_RS04000	COG0521	Mo-molybdopterin cofactor biosynthetic process
FZ025_RS04015	COG1254	Belongs to the acylphosphatase family
FZ025_RS04020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FZ025_RS04025	COG1295	ribonuclease BN
FZ025_RS04045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FZ025_RS04050	COG0473	3-isopropylmalate dehydrogenase activity
FZ025_RS04065	COG4783	chaperone-mediated protein folding
FZ025_RS04080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FZ025_RS04085	COG0248	Ppx GppA phosphatase
FZ025_RS04090	COG0438	transferase activity, transferring glycosyl groups
FZ025_RS04110	COG2833	Protein of unknown function (DUF455)
FZ025_RS04130	COG0285	dihydrofolate synthase activity
FZ025_RS04135	COG0588	phosphoglycerate mutase activity
FZ025_RS04155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FZ025_RS04160	COG4208	sulfate ABC transporter
FZ025_RS04165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FZ025_RS04170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FZ025_RS04175	COG0156	8-amino-7-oxononanoate synthase activity
FZ025_RS04180	COG1187	pseudouridine synthase activity
FZ025_RS04190	COG2885	chlorophyll binding
FZ025_RS04195	COG0583	DNA-binding transcription factor activity
FZ025_RS04200	COG2814	Major facilitator Superfamily
FZ025_RS04210	COG0667	Aldo Keto reductase
FZ025_RS04220	COG0446	pyridine nucleotide-disulphide oxidoreductase
FZ025_RS04220	COG1902	pentaerythritol trinitrate reductase activity
FZ025_RS04240	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FZ025_RS04270	COG1073	alpha beta
FZ025_RS04290	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FZ025_RS04310	COG4585	Histidine kinase
FZ025_RS04320	COG0850	regulation of cytokinetic process
FZ025_RS04325	COG2894	cell division
FZ025_RS04330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FZ025_RS04340	COG2205	protein histidine kinase activity
FZ025_RS04345	COG0745	RESPONSE REGULATOR receiver
FZ025_RS04355	COG2194	sulfuric ester hydrolase activity
FZ025_RS04375	COG2814	Major facilitator Superfamily
FZ025_RS04380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FZ025_RS04380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FZ025_RS04390	COG0753	catalase activity
FZ025_RS04395	COG1063	alcohol dehydrogenase
FZ025_RS04405	COG3459	Glycosyltransferase 36 associated
FZ025_RS04410	COG2186	Transcriptional regulator
FZ025_RS04430	COG2271	Major facilitator Superfamily
FZ025_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS04495	COG1877	trehalose-phosphatase activity
FZ025_RS04500	COG3387	PFAM Glycoside hydrolase 15-related
FZ025_RS04515	COG0840	transmembrane signaling receptor activity
FZ025_RS04530	COG0564	pseudouridine synthase activity
FZ025_RS04535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FZ025_RS04540	COG1125	glycine betaine transport
FZ025_RS04545	COG1174	glycine betaine transport
FZ025_RS04560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FZ025_RS04570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FZ025_RS04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FZ025_RS04575	COG4993	Dehydrogenase
FZ025_RS04600	COG3657	addiction module killer protein
FZ025_RS04605	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FZ025_RS04640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FZ025_RS04655	COG0745	RESPONSE REGULATOR receiver
FZ025_RS04665	COG0189	ligase activity
FZ025_RS04675	COG3511	phospholipase C
FZ025_RS04680	COG5001	Diguanylate cyclase
FZ025_RS04680	COG2203	Gaf domain
FZ025_RS04680	COG3706	GGDEF domain
FZ025_RS04680	COG4251	negative regulation of phosphorylation
FZ025_RS04685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FZ025_RS04690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZ025_RS04700	COG3485	protocatechuate 3,4-dioxygenase
FZ025_RS04705	COG3485	protocatechuate 3,4-dioxygenase
FZ025_RS04715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FZ025_RS04790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FZ025_RS04810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FZ025_RS04810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FZ025_RS04850	COG3634	alkyl hydroperoxide reductase activity
FZ025_RS04855	COG0583	DNA-binding transcription factor activity
FZ025_RS04865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FZ025_RS04890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FZ025_RS04905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FZ025_RS04915	COG0697	spore germination
FZ025_RS04955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZ025_RS04960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZ025_RS04970	COG2096	Adenosyltransferase
FZ025_RS04985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FZ025_RS04990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FZ025_RS04995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FZ025_RS05000	COG2967	ApaG domain
FZ025_RS05005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FZ025_RS05035	COG1704	LemA family
FZ025_RS05040	COG0861	Integral membrane protein TerC family
FZ025_RS05045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FZ025_RS05055	COG0642	Histidine kinase
FZ025_RS05070	COG4181	ATPase activity
FZ025_RS05075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FZ025_RS05080	COG2175	clavaminate synthase activity
FZ025_RS05090	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FZ025_RS05095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZ025_RS05115	COG4771	TonB-dependent receptor
FZ025_RS05125	COG0667	Aldo Keto reductase
FZ025_RS05130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FZ025_RS05140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FZ025_RS05150	COG0242	peptide deformylase activity
FZ025_RS05155	COG0457	Tetratricopeptide repeat
FZ025_RS05160	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FZ025_RS05165	COG1215	transferase activity, transferring glycosyl groups
FZ025_RS05170	COG1215	transferase activity, transferring glycosyl groups
FZ025_RS05185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FZ025_RS05240	COG2188	Transcriptional regulator
FZ025_RS05250	COG1450	Type ii and iii secretion system protein
FZ025_RS05265	COG3166	PFAM Fimbrial assembly family protein
FZ025_RS05270	COG3156	type II secretion system protein K
FZ025_RS05275	COG4795	General secretion pathway protein
FZ025_RS05280	COG2165	general secretion pathway protein
FZ025_RS05285	COG4970	Tfp pilus assembly protein FimT
FZ025_RS05290	COG2165	general secretion pathway protein
FZ025_RS05295	COG1459	type II secretion system
FZ025_RS05300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FZ025_RS05310	COG0047	phosphoribosylformylglycinamidine synthase activity
FZ025_RS05310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FZ025_RS05315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FZ025_RS05320	COG4974	Belongs to the 'phage' integrase family
FZ025_RS05340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FZ025_RS05345	COG2927	DNA polymerase III (CHI subunit)
FZ025_RS05360	COG0525	valine-tRNA ligase activity
FZ025_RS05380	COG1183	phosphatidylcholine synthase activity
FZ025_RS05390	COG0442	prolyl-tRNA aminoacylation
FZ025_RS05405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FZ025_RS05410	COG1127	ABC transporter
FZ025_RS05415	COG3218	ABC-type transport auxiliary lipoprotein component
FZ025_RS05415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FZ025_RS05455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FZ025_RS05460	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FZ025_RS05460	COG0662	Cupin 2, conserved barrel domain protein
FZ025_RS05485	COG2086	electron transfer activity
FZ025_RS05500	COG0463	Glycosyl transferase, family 2
FZ025_RS05510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZ025_RS05520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZ025_RS05525	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FZ025_RS05535	COG0438	transferase activity, transferring glycosyl groups
FZ025_RS05560	COG0626	cystathionine gamma-synthase activity
FZ025_RS05590	COG0625	glutathione transferase activity
FZ025_RS05600	COG0513	Belongs to the DEAD box helicase family
FZ025_RS05610	COG4771	TonB-dependent receptor
FZ025_RS05615	COG0720	synthase
FZ025_RS05625	COG3039	Transposase
FZ025_RS05640	COG0583	DNA-binding transcription factor activity
FZ025_RS05650	COG2814	Major facilitator Superfamily
FZ025_RS05660	COG0583	DNA-binding transcription factor activity
FZ025_RS05665	COG2814	Major facilitator Superfamily
FZ025_RS05670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZ025_RS05680	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS05685	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS05730	COG0583	DNA-binding transcription factor activity
FZ025_RS05735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FZ025_RS05740	COG1956	GAF domain-containing protein
FZ025_RS05750	COG4206	TonB-dependent receptor
FZ025_RS05755	COG0583	DNA-binding transcription factor activity
FZ025_RS05770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZ025_RS05775	COG0546	phosphoglycolate phosphatase activity
FZ025_RS05800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FZ025_RS05815	COG0339	signal peptide processing
FZ025_RS05820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FZ025_RS05830	COG2217	Heavy metal translocating P-type atpase
FZ025_RS05845	COG2132	Multicopper oxidase
FZ025_RS05880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FZ025_RS05890	COG1136	(ABC) transporter
FZ025_RS05890	COG0577	efflux transmembrane transporter activity
FZ025_RS05895	COG0577	efflux transmembrane transporter activity
FZ025_RS05895	COG1136	(ABC) transporter
FZ025_RS05900	COG0577	efflux transmembrane transporter activity
FZ025_RS05900	COG1136	(ABC) transporter
FZ025_RS05905	COG1136	(ABC) transporter
FZ025_RS05905	COG0577	efflux transmembrane transporter activity
FZ025_RS05910	COG0577	efflux transmembrane transporter activity
FZ025_RS05920	COG2204	response regulator
FZ025_RS05925	COG4191	Histidine kinase
FZ025_RS05935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FZ025_RS05950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FZ025_RS05960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FZ025_RS05975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FZ025_RS05985	COG0356	it plays a direct role in the translocation of protons across the membrane
FZ025_RS06000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FZ025_RS06005	COG0508	dehydrogenase complex catalyzes the overall conversion of
FZ025_RS06045	COG0697	spore germination
FZ025_RS06050	COG1666	GTP binding
FZ025_RS06060	COG1187	pseudouridine synthase activity
FZ025_RS06065	COG2813	Specifically methylates the guanine in position
FZ025_RS06085	COG2205	protein histidine kinase activity
FZ025_RS06085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZ025_RS06105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZ025_RS06175	COG0842	Transport permease protein
FZ025_RS06180	COG1131	(ABC) transporter
FZ025_RS06185	COG0025	NhaP-type Na H and K H
FZ025_RS06195	COG1573	uracil-dna glycosylase
FZ025_RS06205	COG3384	dioxygenase
FZ025_RS06230	COG0667	Aldo Keto reductase
FZ025_RS06235	COG0667	Aldo Keto reductase
FZ025_RS06245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FZ025_RS06250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZ025_RS06275	COG5001	Diguanylate cyclase
FZ025_RS06320	COG3039	Transposase
FZ025_RS06345	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS06360	COG0366	Alpha amylase catalytic
FZ025_RS06365	COG0366	Alpha amylase catalytic
FZ025_RS06370	COG3537	Alpha-1,2-mannosidase
FZ025_RS06375	COG1609	Transcriptional regulator
FZ025_RS06390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FZ025_RS06395	COG1490	D-aminoacyl-tRNA deacylase activity
FZ025_RS06405	COG1247	-acetyltransferase
FZ025_RS06410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FZ025_RS06425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FZ025_RS06435	COG0318	PFAM AMP-dependent synthetase and ligase
FZ025_RS06440	COG3268	Saccharopine dehydrogenase
FZ025_RS06460	COG1215	transferase activity, transferring glycosyl groups
FZ025_RS06475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FZ025_RS06480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FZ025_RS06480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FZ025_RS06485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FZ025_RS06490	COG0242	peptide deformylase activity
FZ025_RS06495	COG1652	LysM domain
FZ025_RS06500	COG0758	DNA mediated transformation
FZ025_RS06515	COG1714	RDD family
FZ025_RS06520	COG1754	DNA topoisomerase type I activity
FZ025_RS06520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FZ025_RS06525	COG0009	L-threonylcarbamoyladenylate synthase
FZ025_RS06540	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS06550	COG0616	signal peptide processing
FZ025_RS06555	COG0534	Mate efflux family protein
FZ025_RS06570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FZ025_RS06580	COG1252	NADH dehydrogenase
FZ025_RS06585	COG2860	membrane
FZ025_RS06590	COG1396	sequence-specific DNA binding
FZ025_RS06605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FZ025_RS06610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FZ025_RS06615	COG3437	response regulator, receiver
FZ025_RS06620	COG2177	Part of the ABC transporter FtsEX involved in
FZ025_RS06625	COG2884	Cell division ATP-binding protein ftsE
FZ025_RS06635	COG3118	belongs to the thioredoxin family
FZ025_RS06640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FZ025_RS06650	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FZ025_RS06695	COG1518	maintenance of DNA repeat elements
FZ025_RS06700	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FZ025_RS06710	COG1652	LysM domain
FZ025_RS06725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZ025_RS06730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZ025_RS06745	COG5383	Protein conserved in bacteria
FZ025_RS06795	COG4152	abc transporter atp-binding protein
FZ025_RS06825	COG3409	Peptidoglycan-binding domain 1 protein
FZ025_RS06860	COG4771	TonB-dependent receptor
FZ025_RS06870	COG4948	Mandelate Racemase Muconate Lactonizing
FZ025_RS06880	COG0531	amino acid
FZ025_RS06890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FZ025_RS06905	COG2133	pyrroloquinoline quinone binding
FZ025_RS06920	COG2308	Evidence 4 Homologs of previously reported genes of
FZ025_RS06925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FZ025_RS06935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FZ025_RS06945	COG1295	ribonuclease BN
FZ025_RS06950	COG0358	DNA primase activity
FZ025_RS06965	COG0109	protoheme IX farnesyltransferase activity
FZ025_RS06970	COG1612	heme a metabolic process
FZ025_RS06995	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FZ025_RS07035	COG0793	Belongs to the peptidase S41A family
FZ025_RS07040	COG4942	peptidase
FZ025_RS07050	COG2234	aminopeptidase activity
FZ025_RS07055	COG1064	alcohol dehydrogenase
FZ025_RS07085	COG3135	benzoate transporter
FZ025_RS07105	COG0676	glucose-6-phosphate 1-epimerase activity
FZ025_RS07110	COG3706	GGDEF domain
FZ025_RS07115	COG3012	SEC-C Motif Domain Protein
FZ025_RS07120	COG0730	response to heat
FZ025_RS07150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FZ025_RS07155	COG0302	gtp cyclohydrolase
FZ025_RS07160	COG0477	Major facilitator Superfamily
FZ025_RS07185	COG1396	sequence-specific DNA binding
FZ025_RS07185	COG3800	Transcriptional regulator
FZ025_RS07210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FZ025_RS07215	COG1074	ATP-dependent DNA helicase activity
FZ025_RS07220	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FZ025_RS07230	COG0459	protein refolding
FZ025_RS07235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FZ025_RS07240	COG2356	endonuclease I
FZ025_RS07245	COG1324	tolerance protein
FZ025_RS07255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FZ025_RS07270	COG1733	regulation of RNA biosynthetic process
FZ025_RS07275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FZ025_RS07280	COG0511	ligase activity, forming carbon-carbon bonds
FZ025_RS07290	COG0439	Biotin carboxylase
FZ025_RS07305	COG2264	protein methyltransferase activity
FZ025_RS07320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FZ025_RS07340	COG0151	Belongs to the GarS family
FZ025_RS07410	COG2814	Major facilitator Superfamily
FZ025_RS07415	COG1289	transmembrane transporter activity
FZ025_RS07435	COG4771	TonB-dependent receptor
FZ025_RS07455	COG1051	belongs to the nudix hydrolase family
FZ025_RS07475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FZ025_RS07480	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FZ025_RS07495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FZ025_RS07500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FZ025_RS07505	COG0730	response to heat
FZ025_RS07515	COG0134	indole-3-glycerol-phosphate synthase activity
FZ025_RS07520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FZ025_RS07535	COG1127	ABC transporter
FZ025_RS07540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FZ025_RS07545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FZ025_RS07560	COG2853	Lipoprotein
FZ025_RS07570	COG0386	Belongs to the glutathione peroxidase family
FZ025_RS07575	COG1322	Protein conserved in bacteria
FZ025_RS07580	COG0625	glutathione transferase activity
FZ025_RS07590	COG1285	pathogenesis
FZ025_RS07595	COG4191	Histidine kinase
FZ025_RS07600	COG4566	intracellular signal transduction
FZ025_RS07605	COG0531	amino acid
FZ025_RS07610	COG2814	Major facilitator Superfamily
FZ025_RS07620	COG1929	Belongs to the glycerate kinase type-1 family
FZ025_RS07625	COG0823	Involved in the tonB-independent uptake of proteins
FZ025_RS07625	COG1506	peptidase
FZ025_RS07625	COG4946	Tricorn protease homolog
FZ025_RS07635	COG4771	TonB-dependent receptor
FZ025_RS07645	COG1522	sequence-specific DNA binding
FZ025_RS07670	COG1126	abc transporter atp-binding protein
FZ025_RS07680	COG1473	amidohydrolase
FZ025_RS07685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZ025_RS07690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZ025_RS07700	COG0431	NADPH-dependent FMN reductase
FZ025_RS07705	COG4206	TonB-dependent receptor
FZ025_RS07715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FZ025_RS07735	COG0671	phosphoesterase, PA-phosphatase related
FZ025_RS07745	COG1752	Esterase of the alpha-beta hydrolase superfamily
FZ025_RS07750	COG1522	sequence-specific DNA binding
FZ025_RS07755	COG3186	Phenylalanine-4-hydroxylase
FZ025_RS07780	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS07785	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FZ025_RS07795	COG1609	Transcriptional regulator
FZ025_RS07800	COG3507	Belongs to the glycosyl hydrolase 43 family
FZ025_RS07815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FZ025_RS07825	COG2755	lipolytic protein G-D-S-L family
FZ025_RS07825	COG0657	acetylesterase activity
FZ025_RS07860	COG4772	TonB-dependent receptor
FZ025_RS07935	COG0681	Belongs to the peptidase S26 family
FZ025_RS07950	COG0339	signal peptide processing
FZ025_RS07955	COG1446	asparaginase
FZ025_RS08000	COG2197	response regulator
FZ025_RS08005	COG4585	Histidine kinase
FZ025_RS08040	COG4771	TonB-dependent receptor
FZ025_RS08055	COG1902	pentaerythritol trinitrate reductase activity
FZ025_RS08070	COG1309	transcriptional regulator
FZ025_RS08075	COG2814	Major facilitator Superfamily
FZ025_RS08085	COG0789	Transcriptional regulator
FZ025_RS08105	COG0640	Transcriptional regulator
FZ025_RS08135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FZ025_RS08155	COG2814	Major facilitator Superfamily
FZ025_RS08165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FZ025_RS08180	COG0756	dUTP diphosphatase activity
FZ025_RS08185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FZ025_RS08190	COG2003	Belongs to the UPF0758 family
FZ025_RS08205	COG4221	oxidoreductase activity
FZ025_RS08215	COG2755	lipolytic protein G-D-S-L family
FZ025_RS08215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FZ025_RS08220	COG1166	arginine decarboxylase activity
FZ025_RS08235	COG2960	long-chain fatty acid transporting porin activity
FZ025_RS08240	COG0606	chelatase, subunit chli
FZ025_RS08260	COG4773	Receptor
FZ025_RS08305	COG0840	transmembrane signaling receptor activity
FZ025_RS08360	COG0584	glycerophosphoryl diester phosphodiesterase
FZ025_RS08405	COG0577	efflux transmembrane transporter activity
FZ025_RS08405	COG1136	(ABC) transporter
FZ025_RS08410	COG4591	ABC-type transport system involved in lipoprotein release permease component
FZ025_RS08440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FZ025_RS08465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FZ025_RS08480	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS08500	COG4807	Protein conserved in bacteria
FZ025_RS08515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FZ025_RS08565	COG1181	Belongs to the D-alanine--D-alanine ligase family
FZ025_RS08575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZ025_RS08585	COG0318	PFAM AMP-dependent synthetase and ligase
FZ025_RS08595	COG0583	DNA-binding transcription factor activity
FZ025_RS08610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FZ025_RS08615	COG0596	Alpha beta hydrolase
FZ025_RS08630	COG3177	Filamentation induced by cAMP protein fic
FZ025_RS08635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FZ025_RS08645	COG0612	Peptidase, M16
FZ025_RS08655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FZ025_RS08670	COG1119	ATPase activity
FZ025_RS08685	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FZ025_RS08695	COG1335	isochorismatase
FZ025_RS08710	COG1733	regulation of RNA biosynthetic process
FZ025_RS08720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FZ025_RS08740	COG0594	ribonuclease P activity
FZ025_RS08745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FZ025_RS08755	COG0592	DNA-directed DNA polymerase activity
FZ025_RS08760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FZ025_RS08765	COG0187	DNA topoisomerase II activity
FZ025_RS08770	COG1266	CAAX protease self-immunity
FZ025_RS08775	COG0501	Belongs to the peptidase M48B family
FZ025_RS08805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FZ025_RS08815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FZ025_RS08830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FZ025_RS08835	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FZ025_RS08840	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FZ025_RS08845	COG0493	'glutamate synthase
FZ025_RS08850	COG0067	glutamate synthase
FZ025_RS08850	COG0070	glutamate synthase
FZ025_RS08850	COG0069	glutamate synthase activity
FZ025_RS08880	COG1205	dead DEAH box helicase
FZ025_RS08880	COG1111	helicase
FZ025_RS08925	COG2271	Major facilitator Superfamily
FZ025_RS08985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FZ025_RS09020	COG0183	Belongs to the thiolase family
FZ025_RS09030	COG2032	superoxide dismutase activity
FZ025_RS09035	COG2032	superoxide dismutase activity
FZ025_RS09060	COG2204	response regulator
FZ025_RS09065	COG3852	Histidine kinase
FZ025_RS09070	COG0004	ammonium transporteR
FZ025_RS09075	COG0347	Belongs to the P(II) protein family
FZ025_RS09080	COG0174	glutamine synthetase
FZ025_RS09085	COG1968	undecaprenyl-diphosphatase activity
FZ025_RS09110	COG2050	protein possibly involved in aromatic compounds catabolism
FZ025_RS09115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FZ025_RS09125	COG2062	phosphohistidine phosphatase, SixA
FZ025_RS09130	COG1192	Involved in chromosome partitioning
FZ025_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS09190	COG2207	Transcriptional regulator
FZ025_RS09195	COG4221	oxidoreductase activity
FZ025_RS09205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FZ025_RS09215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FZ025_RS09225	COG1435	thymidine kinase activity
FZ025_RS09230	COG0210	DNA helicase
FZ025_RS09240	COG0752	glycyl-tRNA synthetase alpha subunit
FZ025_RS09245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FZ025_RS09250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FZ025_RS09250	COG0519	Catalyzes the synthesis of GMP from XMP
FZ025_RS09260	COG0805	protein transport
FZ025_RS09270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FZ025_RS09300	COG0180	Tryptophanyl-tRNA synthetase
FZ025_RS09325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FZ025_RS09365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FZ025_RS09370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FZ025_RS09370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FZ025_RS09380	COG3228	Belongs to the MtfA family
FZ025_RS09390	COG2814	Major facilitator Superfamily
FZ025_RS09405	COG1902	pentaerythritol trinitrate reductase activity
FZ025_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS09465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FZ025_RS09475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZ025_RS09480	COG0179	Fumarylacetoacetate (FAA) hydrolase
FZ025_RS09495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FZ025_RS09505	COG0745	RESPONSE REGULATOR receiver
FZ025_RS09510	COG2205	protein histidine kinase activity
FZ025_RS09545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FZ025_RS09550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FZ025_RS09555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FZ025_RS09570	COG1764	response to oxidative stress
FZ025_RS09575	COG1846	Transcriptional regulator
FZ025_RS09580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FZ025_RS09595	COG0523	cobalamin synthesis protein
FZ025_RS09610	COG3245	cytochrome
FZ025_RS09620	COG1960	acyl-CoA dehydrogenase activity
FZ025_RS09625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FZ025_RS09650	COG0697	spore germination
FZ025_RS09670	COG0577	efflux transmembrane transporter activity
FZ025_RS09675	COG1136	(ABC) transporter
FZ025_RS09690	COG4773	Receptor
FZ025_RS09700	COG0753	catalase activity
FZ025_RS09715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FZ025_RS09745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZ025_RS09810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FZ025_RS09815	COG2224	Isocitrate lyase
FZ025_RS09820	COG2963	transposase activity
FZ025_RS09845	COG3706	GGDEF domain
FZ025_RS09870	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS09890	COG0659	secondary active sulfate transmembrane transporter activity
FZ025_RS09920	COG0656	L-ascorbic acid biosynthetic process
FZ025_RS09930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZ025_RS09935	COG2130	NADP-dependent
FZ025_RS09950	COG1187	pseudouridine synthase activity
FZ025_RS09970	COG0084	hydrolase, TatD family'
FZ025_RS09990	COG2323	membrane
FZ025_RS10000	COG0408	coproporphyrinogen oxidase activity
FZ025_RS10015	COG1271	oxidase subunit
FZ025_RS10020	COG1294	oxidase, subunit
FZ025_RS10050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FZ025_RS10065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FZ025_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS10100	COG0463	Glycosyl transferase, family 2
FZ025_RS10110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FZ025_RS10115	COG3100	YcgL domain-containing protein
FZ025_RS10125	COG3387	PFAM Glycoside hydrolase 15-related
FZ025_RS10130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FZ025_RS10145	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS10175	COG0583	DNA-binding transcription factor activity
FZ025_RS10180	COG0667	Aldo Keto reductase
FZ025_RS10200	COG2937	Belongs to the GPAT DAPAT family
FZ025_RS10215	COG1609	Transcriptional regulator
FZ025_RS10235	COG0284	orotidine-5'-phosphate decarboxylase activity
FZ025_RS10245	COG1252	NADH dehydrogenase
FZ025_RS10260	COG3132	Protein of unknown function, DUF480
FZ025_RS10280	COG0729	surface antigen
FZ025_RS10285	COG2911	Protein conserved in bacteria
FZ025_RS10295	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS10395	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS10415	COG4974	Belongs to the 'phage' integrase family
FZ025_RS10440	COG3265	gluconokinase activity
FZ025_RS10455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FZ025_RS10460	COG5001	Diguanylate cyclase
FZ025_RS10470	COG2205	protein histidine kinase activity
FZ025_RS10475	COG0457	Tetratricopeptide repeat
FZ025_RS10495	COG1971	Probably functions as a manganese efflux pump
FZ025_RS10515	COG0477	Major facilitator Superfamily
FZ025_RS10520	COG1011	Hydrolase
FZ025_RS10535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FZ025_RS10545	COG4948	Mandelate Racemase Muconate Lactonizing
FZ025_RS10550	COG2808	Putative FMN-binding domain
FZ025_RS10555	COG1917	Cupin 2, conserved barrel domain protein
FZ025_RS10555	COG4977	sequence-specific DNA binding
FZ025_RS10560	COG0154	amidase activity
FZ025_RS10585	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FZ025_RS10590	COG1012	belongs to the aldehyde dehydrogenase family
FZ025_RS10595	COG0583	DNA-binding transcription factor activity
FZ025_RS10600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FZ025_RS10605	COG0277	FAD linked oxidase domain protein
FZ025_RS10605	COG0247	lactate metabolic process
FZ025_RS10610	COG5383	Protein conserved in bacteria
FZ025_RS10630	COG2091	lysine biosynthetic process via aminoadipic acid
FZ025_RS10635	COG0357	Ribosomal RNA small subunit methyltransferase G
FZ025_RS10640	COG1192	Involved in chromosome partitioning
FZ025_RS10645	COG1475	DNA binding
FZ025_RS10655	COG0463	Glycosyl transferase, family 2
FZ025_RS10680	COG0589	response to stress
FZ025_RS10715	COG0210	DNA helicase
FZ025_RS10720	COG0583	DNA-binding transcription factor activity
FZ025_RS10725	COG0477	Major facilitator Superfamily
FZ025_RS10740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FZ025_RS10745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FZ025_RS10760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZ025_RS10780	COG0037	tRNA processing
FZ025_RS10785	COG2974	May be involved in recombination
FZ025_RS10795	COG0842	Transport permease protein
FZ025_RS10800	COG1131	(ABC) transporter
FZ025_RS10805	COG0633	Ferredoxin
FZ025_RS10805	COG0543	2 iron, 2 sulfur cluster binding
FZ025_RS10815	COG4555	ABC transporter
FZ025_RS10835	COG0625	glutathione transferase activity
FZ025_RS10870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FZ025_RS10890	COG1199	ATP-dependent helicase activity
FZ025_RS10935	COG0628	permease
FZ025_RS10995	COG0714	Associated with various cellular activities
FZ025_RS11030	COG1522	sequence-specific DNA binding
FZ025_RS11035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FZ025_RS11050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZ025_RS11055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZ025_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS11115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FZ025_RS11140	COG2207	Transcriptional regulator
FZ025_RS11150	COG4773	Receptor
FZ025_RS11155	COG2814	Major facilitator Superfamily
FZ025_RS11160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FZ025_RS11170	COG0531	amino acid
FZ025_RS11255	COG0697	spore germination
FZ025_RS11260	COG1113	amino acid transport
FZ025_RS11275	COG2207	Transcriptional regulator
FZ025_RS11300	COG0513	Belongs to the DEAD box helicase family
FZ025_RS11325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FZ025_RS11335	COG3483	tryptophan 2,3-dioxygenase activity
FZ025_RS11340	COG3104	oligopeptide transport
FZ025_RS11360	COG2852	Protein conserved in bacteria
FZ025_RS11385	COG1320	monovalent cation:proton antiporter activity
FZ025_RS11390	COG2212	antiporter activity
FZ025_RS11395	COG1863	multisubunit Na H antiporter MnhE subunit
FZ025_RS11400	COG0651	ATP synthesis coupled electron transport
FZ025_RS11405	COG1006	Multisubunit Na H antiporter MnhC subunit
FZ025_RS11410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FZ025_RS11410	COG2111	Na H antiporter
FZ025_RS11415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZ025_RS11440	COG2814	Major facilitator Superfamily
FZ025_RS11445	COG4942	peptidase
FZ025_RS11470	COG0484	heat shock protein binding
FZ025_RS11485	COG1597	lipid kinase activity
FZ025_RS11505	COG3264	Mechanosensitive ion channel
FZ025_RS11505	COG1196	nuclear chromosome segregation
FZ025_RS11535	COG2354	Protein conserved in bacteria
FZ025_RS11540	COG3706	GGDEF domain
FZ025_RS11545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZ025_RS11565	COG0741	lytic transglycosylase activity
FZ025_RS11580	COG0612	Peptidase, M16
FZ025_RS11595	COG0531	amino acid
FZ025_RS11610	COG3275	phosphorelay sensor kinase activity
FZ025_RS11615	COG3279	Response regulator of the LytR AlgR family
FZ025_RS11640	COG2124	cytochrome p450
FZ025_RS11640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FZ025_RS11660	COG0745	RESPONSE REGULATOR receiver
FZ025_RS11675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FZ025_RS11675	COG2885	chlorophyll binding
FZ025_RS11695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FZ025_RS11715	COG0028	Belongs to the TPP enzyme family
FZ025_RS11720	COG1648	precorrin-2 dehydrogenase activity
FZ025_RS11720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FZ025_RS11730	COG1116	anion transmembrane transporter activity
FZ025_RS11730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FZ025_RS11750	COG2223	nitrite transmembrane transporter activity
FZ025_RS11755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FZ025_RS11760	COG2146	nitrite reductase [NAD(P)H] activity
FZ025_RS11765	COG0243	molybdopterin cofactor binding
FZ025_RS11790	COG1640	4-alpha-glucanotransferase
FZ025_RS11795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FZ025_RS11815	COG0745	RESPONSE REGULATOR receiver
FZ025_RS11840	COG0181	hydroxymethylbilane synthase activity
FZ025_RS11855	COG1733	regulation of RNA biosynthetic process
FZ025_RS11870	COG1505	serine-type exopeptidase activity
FZ025_RS11895	COG2832	Protein of unknown function (DUF454)
FZ025_RS11925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FZ025_RS11945	COG2226	methyltransferase
FZ025_RS11950	COG0308	aminopeptidase N
FZ025_RS11955	COG0508	dehydrogenase complex catalyzes the overall conversion of
FZ025_RS11955	COG0596	Alpha beta hydrolase
FZ025_RS11980	COG2010	Cytochrome c
FZ025_RS11990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FZ025_RS12010	COG0730	response to heat
FZ025_RS12015	COG1012	belongs to the aldehyde dehydrogenase family
FZ025_RS12025	COG1213	nucleotidyl transferase
FZ025_RS12035	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
FZ025_RS12035	COG0028	Belongs to the TPP enzyme family
FZ025_RS12050	COG3284	Transcriptional regulator
FZ025_RS12060	COG1077	Cell shape determining protein MreB Mrl
FZ025_RS12065	COG1792	Involved in formation and maintenance of cell shape
FZ025_RS12080	COG0772	Belongs to the SEDS family
FZ025_RS12090	COG5434	Belongs to the glycosyl hydrolase 28 family
FZ025_RS12095	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FZ025_RS12100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FZ025_RS12105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FZ025_RS12110	COG1012	belongs to the aldehyde dehydrogenase family
FZ025_RS12115	COG2951	lytic endotransglycosylase activity
FZ025_RS12125	COG1686	Belongs to the peptidase S11 family
FZ025_RS12150	COG2921	Belongs to the UPF0250 family
FZ025_RS12160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FZ025_RS12195	COG1090	epimerase
FZ025_RS12205	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FZ025_RS12210	COG0673	inositol 2-dehydrogenase activity
FZ025_RS12215	COG2823	Periplasmic or secreted lipoprotein
FZ025_RS12225	COG2202	Pas domain
FZ025_RS12225	COG2205	protein histidine kinase activity
FZ025_RS12230	COG0784	Response regulator, receiver
FZ025_RS12235	COG4191	Histidine kinase
FZ025_RS12245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FZ025_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS12270	COG3250	beta-galactosidase activity
FZ025_RS12285	COG2188	Transcriptional regulator
FZ025_RS12290	COG0738	Major facilitator superfamily
FZ025_RS12295	COG1609	Transcriptional regulator
FZ025_RS12300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FZ025_RS12305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FZ025_RS12365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FZ025_RS12375	COG2207	Transcriptional regulator
FZ025_RS12405	COG2205	protein histidine kinase activity
FZ025_RS12410	COG0745	RESPONSE REGULATOR receiver
FZ025_RS12425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FZ025_RS12430	COG3791	Glutathione-dependent formaldehyde-activating
FZ025_RS12440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZ025_RS12450	COG0697	spore germination
FZ025_RS12460	COG1307	EDD domain protein, DegV family
FZ025_RS12500	COG3459	Glycosyltransferase 36 associated
FZ025_RS12505	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS12510	COG3459	Glycosyltransferase 36 associated
FZ025_RS12525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FZ025_RS12540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FZ025_RS12545	COG0726	polysaccharide deacetylase
FZ025_RS12605	COG1162	GTPase activity
FZ025_RS12625	COG4206	TonB-dependent receptor
FZ025_RS12630	COG2211	Major facilitator Superfamily
FZ025_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS12645	COG2851	Citrate transporter
FZ025_RS12660	COG0642	Histidine kinase
FZ025_RS12665	COG1840	ABC-type Fe3 transport system, periplasmic component
FZ025_RS12685	COG4191	Histidine kinase
FZ025_RS12700	COG1301	dicarboxylic acid transport
FZ025_RS12755	COG1560	Kdo2-lipid A biosynthetic process
FZ025_RS12760	COG1519	Transferase
FZ025_RS12765	COG1538	Outer membrane efflux protein
FZ025_RS12770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FZ025_RS12780	COG3706	GGDEF domain
FZ025_RS12785	COG0473	3-isopropylmalate dehydrogenase activity
FZ025_RS12790	COG0066	3-isopropylmalate dehydratase activity
FZ025_RS12805	COG4106	trans-aconitate 2-methyltransferase activity
FZ025_RS12810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FZ025_RS12835	COG0405	Gamma-glutamyltransferase
FZ025_RS12840	COG0823	Involved in the tonB-independent uptake of proteins
FZ025_RS12840	COG1506	peptidase
FZ025_RS12840	COG4946	Tricorn protease homolog
FZ025_RS12845	COG0840	transmembrane signaling receptor activity
FZ025_RS12870	COG4206	TonB-dependent receptor
FZ025_RS12880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FZ025_RS12890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FZ025_RS12915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FZ025_RS12940	COG0586	Pfam SNARE associated Golgi protein
FZ025_RS12950	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS12955	COG1940	carbohydrate kinase activity
FZ025_RS12960	COG0346	lactoylglutathione lyase activity
FZ025_RS12975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FZ025_RS12985	COG4206	TonB-dependent receptor
FZ025_RS12995	COG2010	Cytochrome c
FZ025_RS13005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FZ025_RS13020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FZ025_RS13035	COG1773	rubredoxin
FZ025_RS13040	COG2912	Transglutaminase-like superfamily
FZ025_RS13050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FZ025_RS13060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FZ025_RS13090	COG3079	Belongs to the UPF0149 family
FZ025_RS13095	COG0006	proline dipeptidase activity
FZ025_RS13100	COG0006	proline dipeptidase activity
FZ025_RS13115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FZ025_RS13120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FZ025_RS13125	COG0346	lactoylglutathione lyase activity
FZ025_RS13130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FZ025_RS13135	COG1561	YicC-like family, N-terminal region
FZ025_RS13145	COG0848	biopolymer transport protein
FZ025_RS13160	COG2832	Protein of unknown function (DUF454)
FZ025_RS13185	COG3712	iron ion homeostasis
FZ025_RS13195	COG0194	GDP metabolic process
FZ025_RS13200	COG1758	RNA polymerase activity
FZ025_RS13205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FZ025_RS13215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FZ025_RS13225	COG0254	rRNA binding
FZ025_RS13250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FZ025_RS13295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FZ025_RS13300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FZ025_RS13310	COG2205	protein histidine kinase activity
FZ025_RS13315	COG0745	RESPONSE REGULATOR receiver
FZ025_RS13330	COG0277	FAD linked oxidase domain protein
FZ025_RS13335	COG1988	membrane-bound metal-dependent
FZ025_RS13375	COG2001	Belongs to the MraZ family
FZ025_RS13380	COG0275	rRNA processing
FZ025_RS13385	COG3116	cell division
FZ025_RS13400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FZ025_RS13420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FZ025_RS13425	COG1181	Belongs to the D-alanine--D-alanine ligase family
FZ025_RS13430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FZ025_RS13440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FZ025_RS13445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FZ025_RS13455	COG0739	heme binding
FZ025_RS13460	COG0653	protein targeting
FZ025_RS13470	COG0494	nUDIX hydrolase
FZ025_RS13480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FZ025_RS13540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FZ025_RS13565	COG0515	serine threonine protein kinase
FZ025_RS13580	COG0488	(ABC) transporter
FZ025_RS13595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FZ025_RS13605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FZ025_RS13605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FZ025_RS13620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FZ025_RS13625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FZ025_RS13635	COG0714	Associated with various cellular activities
FZ025_RS13665	COG1301	dicarboxylic acid transport
FZ025_RS13670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FZ025_RS13720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FZ025_RS13725	COG4149	molybdate abc transporter
FZ025_RS13730	COG0725	ABC transporter, periplasmic molybdate-binding protein
FZ025_RS13740	COG0640	Transcriptional regulator
FZ025_RS13765	COG3047	cAMP biosynthetic process
FZ025_RS13775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FZ025_RS13785	COG3657	addiction module killer protein
FZ025_RS13795	COG0210	DNA helicase
FZ025_RS13800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FZ025_RS13805	COG0736	holo-[acyl-carrier-protein] synthase activity
FZ025_RS13850	COG1475	DNA binding
FZ025_RS13855	COG5489	Protein of unknown function (DUF736)
FZ025_RS13890	COG1192	Involved in chromosome partitioning
FZ025_RS13915	COG0583	DNA-binding transcription factor activity
FZ025_RS13920	COG2814	Major facilitator Superfamily
FZ025_RS13925	COG1902	pentaerythritol trinitrate reductase activity
FZ025_RS13930	COG0583	DNA-binding transcription factor activity
FZ025_RS13940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZ025_RS13955	COG0583	DNA-binding transcription factor activity
FZ025_RS13975	COG4962	Type ii secretion system protein e
FZ025_RS13980	COG3838	Conjugal transfer protein Trbc
FZ025_RS13990	COG3451	type IV secretory pathway VirB4
FZ025_RS14005	COG3846	protein secretion by the type IV secretion system
FZ025_RS14015	COG3504	Conjugal transfer protein
FZ025_RS14050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZ025_RS14055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZ025_RS14090	COG0469	pyruvate kinase activity
FZ025_RS14095	COG3588	fructose-bisphosphate aldolase
FZ025_RS14100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FZ025_RS14105	COG2252	PERMEase
FZ025_RS14115	COG1957	nucleoside hydrolase
FZ025_RS14150	COG4771	TonB-dependent receptor
FZ025_RS14160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FZ025_RS14175	COG0277	FAD linked oxidase domain protein
FZ025_RS14180	COG1132	(ABC) transporter
FZ025_RS14185	COG2897	thiosulfate sulfurtransferase activity
FZ025_RS14205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FZ025_RS14225	COG2072	flavoprotein involved in K transport
FZ025_RS14230	COG2351	hydroxyisourate hydrolase activity
FZ025_RS14240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FZ025_RS14285	COG0840	transmembrane signaling receptor activity
FZ025_RS14290	COG0431	NADPH-dependent FMN reductase
FZ025_RS14320	COG0175	sulfate reduction
FZ025_RS14325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FZ025_RS14330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FZ025_RS14340	COG2895	sulfate adenylyltransferase (ATP) activity
FZ025_RS14340	COG0529	Catalyzes the synthesis of activated sulfate
FZ025_RS14345	COG0438	transferase activity, transferring glycosyl groups
FZ025_RS14365	COG1115	amino acid carrier protein
FZ025_RS14375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FZ025_RS14385	COG1609	Transcriptional regulator
FZ025_RS14400	COG0179	Fumarylacetoacetate (FAA) hydrolase
FZ025_RS14415	COG3273	potassium ion transport
FZ025_RS14415	COG0471	metal ion transport
FZ025_RS14420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FZ025_RS14460	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FZ025_RS14465	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FZ025_RS14480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FZ025_RS14485	COG1404	Belongs to the peptidase S8 family
FZ025_RS14520	COG0544	peptidyl-prolyl cis-trans isomerase activity
FZ025_RS14525	COG0740	serine-type endopeptidase activity
FZ025_RS14530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FZ025_RS14570	COG2801	Transposase and inactivated derivatives
FZ025_RS14575	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS14665	COG3942	CHAP domain
FZ025_RS14665	COG1388	LysM domain
FZ025_RS14670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZ025_RS14680	COG0328	RNA-DNA hybrid ribonuclease activity
FZ025_RS14685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FZ025_RS14690	COG0631	protein serine/threonine phosphatase activity
FZ025_RS14700	COG0583	DNA-binding transcription factor activity
FZ025_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS14730	COG0859	PFAM glycosyl transferase family 9
FZ025_RS14740	COG1234	tRNA 3'-trailer cleavage
FZ025_RS14745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FZ025_RS14760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FZ025_RS14765	COG0314	molybdopterin synthase activity
FZ025_RS14775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FZ025_RS14785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FZ025_RS14795	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FZ025_RS14835	COG4680	protein conserved in bacteria
FZ025_RS14860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FZ025_RS14870	COG0537	adenosine 5'-monophosphoramidase activity
FZ025_RS14890	COG0714	Associated with various cellular activities
FZ025_RS14915	COG1399	metal-binding, possibly nucleic acid-binding protein
FZ025_RS14920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FZ025_RS14925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FZ025_RS14930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FZ025_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS14950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FZ025_RS14955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FZ025_RS14960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FZ025_RS14985	COG4115	mRNA cleavage
FZ025_RS14990	COG2161	toxin-antitoxin pair type II binding
FZ025_RS15000	COG0640	Transcriptional regulator
FZ025_RS15035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FZ025_RS15040	COG0372	Belongs to the citrate synthase family
FZ025_RS15065	COG3609	addiction module antidote protein, CC2985 family
FZ025_RS15085	COG4771	TonB-dependent receptor
FZ025_RS15095	COG2373	Large extracellular alpha-helical protein
FZ025_RS15120	COG1136	(ABC) transporter
FZ025_RS15160	COG0641	radical SAM
FZ025_RS15200	COG1136	(ABC) transporter
FZ025_RS15200	COG0577	efflux transmembrane transporter activity
FZ025_RS15220	COG2204	response regulator
FZ025_RS15230	COG4953	penicillin-binding protein 1C
FZ025_RS15240	COG0678	peroxiredoxin activity
FZ025_RS15250	COG0484	heat shock protein binding
FZ025_RS15255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZ025_RS15275	COG1199	ATP-dependent helicase activity
FZ025_RS15305	COG0189	ligase activity
FZ025_RS15320	COG0835	chemotaxis
FZ025_RS15325	COG0840	transmembrane signaling receptor activity
FZ025_RS15335	COG2201	protein-glutamate methylesterase activity
FZ025_RS15355	COG1446	asparaginase
FZ025_RS15405	COG3537	Alpha-1,2-mannosidase
FZ025_RS15415	COG1472	Belongs to the glycosyl hydrolase 3 family
FZ025_RS15425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FZ025_RS15430	COG3858	chitin binding
FZ025_RS15430	COG1388	LysM domain
FZ025_RS15445	COG0837	glucose binding
FZ025_RS15450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FZ025_RS15460	COG0494	nUDIX hydrolase
FZ025_RS15470	COG3956	TIGRFAM MazG family protein
FZ025_RS15475	COG1742	UPF0060 membrane protein
FZ025_RS15485	COG0330	HflC and HflK could
FZ025_RS15500	COG0604	alcohol dehydrogenase
FZ025_RS15505	COG0330	HflC and HflK could
FZ025_RS15510	COG0330	HflC and HflK could
FZ025_RS15520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FZ025_RS15570	COG1187	pseudouridine synthase activity
FZ025_RS15625	COG1132	(ABC) transporter
FZ025_RS15685	COG0825	malonyl-CoA metabolic process
FZ025_RS15695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FZ025_RS15705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FZ025_RS15715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FZ025_RS15725	COG0750	zinc metalloprotease
FZ025_RS15730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FZ025_RS15735	COG0575	Belongs to the CDS family
FZ025_RS15740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FZ025_RS15755	COG3706	GGDEF domain
FZ025_RS15760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FZ025_RS15765	COG0052	Belongs to the universal ribosomal protein uS2 family
FZ025_RS15800	COG0024	Methionine aminopeptidase
FZ025_RS15815	COG1393	Belongs to the ArsC family
FZ025_RS15820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FZ025_RS15825	COG0367	asparagine synthase
FZ025_RS15865	COG1566	PFAM secretion protein HlyD family protein
FZ025_RS15870	COG2814	Major facilitator Superfamily
FZ025_RS15895	COG3590	peptidase
FZ025_RS15930	COG0745	RESPONSE REGULATOR receiver
FZ025_RS15965	COG4794	Type iii secretion
FZ025_RS15990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FZ025_RS16015	COG1317	bacterial-type flagellum organization
FZ025_RS16035	COG2207	Transcriptional regulator
FZ025_RS16065	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS16085	COG0625	glutathione transferase activity
FZ025_RS16095	COG0475	glutathione-regulated potassium exporter activity
FZ025_RS16105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FZ025_RS16130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FZ025_RS16135	COG2070	2-Nitropropane dioxygenase
FZ025_RS16145	COG0228	four-way junction DNA binding
FZ025_RS16150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FZ025_RS16160	COG0335	large ribosomal subunit rRNA binding
FZ025_RS16165	COG0534	Mate efflux family protein
FZ025_RS16180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FZ025_RS16190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FZ025_RS16205	COG3250	beta-galactosidase activity
FZ025_RS16210	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FZ025_RS16225	COG2855	membrane
FZ025_RS16235	COG1024	Enoyl-CoA hydratase
FZ025_RS16235	COG1250	3-hydroxyacyl-CoA dehydrogenase
FZ025_RS16250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZ025_RS16260	COG0681	Belongs to the peptidase S26 family
FZ025_RS16275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FZ025_RS16285	COG2198	Histidine kinase
FZ025_RS16285	COG5002	protein histidine kinase activity
FZ025_RS16285	COG0784	Response regulator, receiver
FZ025_RS16305	COG1472	Belongs to the glycosyl hydrolase 3 family
FZ025_RS16315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FZ025_RS16320	COG1278	Cold shock
FZ025_RS16355	COG0438	transferase activity, transferring glycosyl groups
FZ025_RS16360	COG0438	transferase activity, transferring glycosyl groups
FZ025_RS16395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FZ025_RS16405	COG1960	acyl-CoA dehydrogenase activity
FZ025_RS16450	COG1570	exodeoxyribonuclease VII activity
FZ025_RS16455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FZ025_RS16460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FZ025_RS16460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FZ025_RS16465	COG0802	atpase or kinase
FZ025_RS16470	COG0860	N-Acetylmuramoyl-L-alanine amidase
FZ025_RS16475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FZ025_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS16515	COG2081	HI0933 family
FZ025_RS16520	COG4681	YaeQ
FZ025_RS16525	COG0564	pseudouridine synthase activity
FZ025_RS16535	COG0625	glutathione transferase activity
FZ025_RS16545	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FZ025_RS16570	COG0513	Belongs to the DEAD box helicase family
FZ025_RS16595	COG2207	Transcriptional regulator
FZ025_RS16605	COG4585	Histidine kinase
FZ025_RS16610	COG2197	response regulator
FZ025_RS16655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FZ025_RS16660	COG1846	Transcriptional regulator
FZ025_RS16665	COG0339	signal peptide processing
FZ025_RS16675	COG0386	Belongs to the glutathione peroxidase family
FZ025_RS16730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FZ025_RS16735	COG0084	hydrolase, TatD family'
FZ025_RS16750	COG1960	acyl-CoA dehydrogenase activity
FZ025_RS16765	COG0305	Participates in initiation and elongation during chromosome replication
FZ025_RS16775	COG4191	Histidine kinase
FZ025_RS16775	COG0784	Response regulator, receiver
FZ025_RS16780	COG2204	response regulator
FZ025_RS16785	COG2204	response regulator
FZ025_RS16790	COG0415	Belongs to the DNA photolyase family
FZ025_RS16805	COG0583	DNA-binding transcription factor activity
FZ025_RS16820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZ025_RS16845	COG3706	GGDEF domain
FZ025_RS16860	COG1404	Belongs to the peptidase S8 family
FZ025_RS16870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FZ025_RS16875	COG1862	Preprotein translocase
FZ025_RS16885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FZ025_RS16910	COG1509	lysine 2,3-aminomutase activity
FZ025_RS16925	COG0402	S-adenosylhomocysteine deaminase activity
FZ025_RS16945	COG5434	Belongs to the glycosyl hydrolase 28 family
FZ025_RS16950	COG4677	pectinesterase activity
FZ025_RS16965	COG4302	ethanolamine ammonia-lyase activity
FZ025_RS16970	COG4303	Ethanolamine ammonia lyase large subunit
FZ025_RS16985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FZ025_RS16995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FZ025_RS17010	COG2166	iron-sulfur cluster assembly
FZ025_RS17025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FZ025_RS17030	COG0137	argininosuccinate synthase activity
FZ025_RS17045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FZ025_RS17055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FZ025_RS17060	COG0165	Argininosuccinate lyase
FZ025_RS17075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FZ025_RS17095	COG1136	(ABC) transporter
FZ025_RS17110	COG1668	transmembrane transport
FZ025_RS17115	COG4555	ABC transporter
FZ025_RS17165	COG1294	oxidase, subunit
FZ025_RS17175	COG4988	ABC transporter
FZ025_RS17180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FZ025_RS17185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZ025_RS17210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FZ025_RS17230	COG4133	protoheme IX ABC transporter activity
FZ025_RS17235	COG0436	Aminotransferase
FZ025_RS17255	COG1187	pseudouridine synthase activity
FZ025_RS17260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FZ025_RS17265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FZ025_RS17270	COG2350	Protein conserved in bacteria
FZ025_RS17295	COG2182	Extracellular solute-binding protein
FZ025_RS17305	COG0395	ABC-type sugar transport system, permease component
FZ025_RS17315	COG0800	Aldolase
FZ025_RS17320	COG0129	dihydroxy-acid dehydratase activity
FZ025_RS17335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FZ025_RS17340	COG3842	ATPase activity
FZ025_RS17355	COG2009	succinate dehydrogenase
FZ025_RS17360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FZ025_RS17385	COG4591	ABC-type transport system involved in lipoprotein release permease component
FZ025_RS17400	COG1289	transmembrane transporter activity
FZ025_RS17415	COG2333	competence protein COMEC
FZ025_RS17415	COG0658	competence protein
FZ025_RS17420	COG0811	peptide transport
FZ025_RS17430	COG1132	(ABC) transporter
FZ025_RS17460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FZ025_RS17460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZ025_RS17470	COG4191	Histidine kinase
FZ025_RS17470	COG0784	Response regulator, receiver
FZ025_RS17475	COG2183	response to ionizing radiation
FZ025_RS17480	COG0784	Response regulator, receiver
FZ025_RS17480	COG2205	protein histidine kinase activity
FZ025_RS17495	COG0604	alcohol dehydrogenase
FZ025_RS17515	COG3246	L-lysine catabolic process to acetate
FZ025_RS17520	COG0583	DNA-binding transcription factor activity
FZ025_RS17525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZ025_RS17535	COG1024	Enoyl-CoA hydratase
FZ025_RS17545	COG1454	alcohol dehydrogenase
FZ025_RS17555	COG2124	cytochrome p450
FZ025_RS17640	COG5000	phosphorelay sensor kinase activity
FZ025_RS17640	COG5002	protein histidine kinase activity
FZ025_RS17650	COG1132	(ABC) transporter
FZ025_RS17670	COG5001	Diguanylate cyclase
FZ025_RS17695	COG2850	peptidyl-arginine hydroxylation
FZ025_RS17735	COG1131	(ABC) transporter
FZ025_RS17740	COG1725	Transcriptional regulator
FZ025_RS17750	COG0386	Belongs to the glutathione peroxidase family
FZ025_RS17765	COG2900	Belongs to the SlyX family
FZ025_RS17775	COG2755	lipolytic protein G-D-S-L family
FZ025_RS17775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FZ025_RS17785	COG0646	methionine synthase
FZ025_RS17785	COG1410	methionine synthase
FZ025_RS17790	COG1410	methionine synthase
FZ025_RS17790	COG0646	methionine synthase
FZ025_RS17800	COG1960	acyl-CoA dehydrogenase activity
FZ025_RS17805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZ025_RS17820	COG2902	Dehydrogenase
FZ025_RS17870	COG2925	Exonuclease
FZ025_RS17880	COG3844	kynureninase activity
FZ025_RS17895	COG0288	reversible hydration of carbon dioxide
FZ025_RS17920	COG0316	Belongs to the HesB IscA family
FZ025_RS17925	COG0582	viral genome integration into host DNA
FZ025_RS17930	COG0582	viral genome integration into host DNA
FZ025_RS17950	COG3177	Filamentation induced by cAMP protein fic
FZ025_RS17960	COG0583	DNA-binding transcription factor activity
FZ025_RS17965	COG2814	Major facilitator Superfamily
FZ025_RS18010	COG0359	binds to the 23S rRNA
FZ025_RS18020	COG3115	cell septum assembly
FZ025_RS18025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FZ025_RS18030	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FZ025_RS18050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZ025_RS18060	COG1253	flavin adenine dinucleotide binding
FZ025_RS18070	COG0306	phosphate transporter
FZ025_RS18090	COG0504	CTP synthase activity
FZ025_RS18110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FZ025_RS18115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FZ025_RS18130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FZ025_RS18140	COG1238	metal cluster binding
FZ025_RS18155	COG1534	Rna-binding protein
FZ025_RS18165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FZ025_RS18170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FZ025_RS18180	COG1923	regulation of RNA biosynthetic process
FZ025_RS18185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FZ025_RS18190	COG0477	Major facilitator Superfamily
FZ025_RS18195	COG1546	Belongs to the CinA family
FZ025_RS18200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FZ025_RS18205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FZ025_RS18210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FZ025_RS18215	COG2137	regulation of response to DNA damage stimulus
FZ025_RS18220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FZ025_RS18225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FZ025_RS18275	COG1741	Belongs to the pirin family
FZ025_RS18280	COG0583	DNA-binding transcription factor activity
FZ025_RS18305	COG0352	thiamine-phosphate diphosphorylase activity
FZ025_RS18305	COG0351	phosphomethylpyrimidine kinase
FZ025_RS18320	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FZ025_RS18325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FZ025_RS18335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZ025_RS18350	COG0366	Alpha amylase catalytic
FZ025_RS18360	COG1082	Xylose isomerase domain protein TIM barrel
FZ025_RS18370	COG2211	Major facilitator Superfamily
FZ025_RS18370	COG2190	(PTS) system
FZ025_RS18405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FZ025_RS18410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FZ025_RS18415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FZ025_RS18425	COG0072	phenylalanine-tRNA ligase activity
FZ025_RS18425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FZ025_RS18430	COG0776	regulation of translation
FZ025_RS18450	COG1530	ribonuclease E activity
FZ025_RS18480	COG0316	Belongs to the HesB IscA family
FZ025_RS18480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FZ025_RS18500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZ025_RS18520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FZ025_RS18525	COG2957	Belongs to the agmatine deiminase family
FZ025_RS18535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FZ025_RS18540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FZ025_RS18545	COG0539	negative regulation of cytoplasmic translation
FZ025_RS18550	COG0776	regulation of translation
FZ025_RS18560	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FZ025_RS18565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FZ025_RS18575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FZ025_RS18580	COG0183	Belongs to the thiolase family
FZ025_RS18585	COG1024	Enoyl-CoA hydratase
FZ025_RS18585	COG1250	3-hydroxyacyl-CoA dehydrogenase
FZ025_RS18595	COG0105	UTP biosynthetic process
FZ025_RS18610	COG1426	Protein conserved in bacteria
FZ025_RS18620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FZ025_RS18630	COG0746	molybdenum cofactor guanylyltransferase activity
FZ025_RS18640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FZ025_RS18645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FZ025_RS18645	COG0475	glutathione-regulated potassium exporter activity
FZ025_RS18660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FZ025_RS18670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FZ025_RS18670	COG0519	Catalyzes the synthesis of GMP from XMP
FZ025_RS18690	COG0736	holo-[acyl-carrier-protein] synthase activity
FZ025_RS18725	COG3039	Transposase
FZ025_RS18755	COG1335	isochorismatase
FZ025_RS18770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FZ025_RS18780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FZ025_RS18785	COG0277	FAD linked oxidase domain protein
FZ025_RS18805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FZ025_RS18820	COG1024	Enoyl-CoA hydratase
FZ025_RS18855	COG0505	Belongs to the CarA family
FZ025_RS18865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FZ025_RS18870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FZ025_RS18885	COG4676	Protein conserved in bacteria
FZ025_RS18890	COG3279	Response regulator of the LytR AlgR family
FZ025_RS18910	COG0784	Response regulator, receiver
FZ025_RS18910	COG2198	Histidine kinase
FZ025_RS18910	COG2205	protein histidine kinase activity
FZ025_RS18915	COG1024	Enoyl-CoA hydratase
FZ025_RS18925	COG0318	PFAM AMP-dependent synthetase and ligase
FZ025_RS18960	COG2201	protein-glutamate methylesterase activity
FZ025_RS18975	COG0840	transmembrane signaling receptor activity
FZ025_RS18980	COG0840	transmembrane signaling receptor activity
FZ025_RS18980	COG0840	transmembrane signaling receptor activity
FZ025_RS18985	COG0840	transmembrane signaling receptor activity
FZ025_RS18995	COG0835	chemotaxis
FZ025_RS19005	COG0840	transmembrane signaling receptor activity
FZ025_RS19015	COG0840	transmembrane signaling receptor activity
FZ025_RS19025	COG0840	transmembrane signaling receptor activity
FZ025_RS19035	COG0745	RESPONSE REGULATOR receiver
FZ025_RS19050	COG1192	Involved in chromosome partitioning
FZ025_RS19060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FZ025_RS19065	COG2198	Histidine kinase
FZ025_RS19065	COG0643	Histidine kinase
FZ025_RS19070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FZ025_RS19085	COG0455	bacterial-type flagellum organization
FZ025_RS19105	COG1684	flagellar biosynthetic protein fliR
FZ025_RS19110	COG1987	bacterial-type flagellum assembly
FZ025_RS19120	COG3190	flagellar
FZ025_RS19170	COG1677	Flagellar hook-basal body complex protein FliE
FZ025_RS19200	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS19205	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS19210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FZ025_RS19225	COG2204	response regulator
FZ025_RS19230	COG2201	protein-glutamate methylesterase activity
FZ025_RS19240	COG2197	response regulator
FZ025_RS19260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FZ025_RS19265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FZ025_RS19275	COG1256	bacterial-type flagellum assembly
FZ025_RS19275	COG4786	Flagellar basal body rod
FZ025_RS19275	COG1256	bacterial-type flagellum assembly
FZ025_RS19275	COG4786	Flagellar basal body rod
FZ025_RS19290	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FZ025_RS19295	COG4786	Flagellar basal body rod
FZ025_RS19305	COG1749	Flagellar hook protein flgE
FZ025_RS19310	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FZ025_RS19315	COG1558	bacterial-type flagellum-dependent cell motility
FZ025_RS19325	COG0784	Response regulator, receiver
FZ025_RS19325	COG0835	chemotaxis
FZ025_RS19370	COG1116	anion transmembrane transporter activity
FZ025_RS19385	COG2915	High frequency lysogenization protein hflD homolog
FZ025_RS19390	COG0482	sulfurtransferase activity
FZ025_RS19410	COG0542	response to heat
FZ025_RS19415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FZ025_RS19420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FZ025_RS19430	COG0492	ferredoxin-NADP+ reductase activity
FZ025_RS19435	COG1674	ftsk spoiiie
FZ025_RS19460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FZ025_RS19465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FZ025_RS19530	COG1595	DNA-templated transcription, initiation
FZ025_RS19580	COG2244	polysaccharide biosynthetic process
FZ025_RS19600	COG4106	trans-aconitate 2-methyltransferase activity
FZ025_RS19620	COG0297	glycogen (starch) synthase activity
FZ025_RS19625	COG0438	transferase activity, transferring glycosyl groups
FZ025_RS19645	COG1132	(ABC) transporter
FZ025_RS19725	COG4942	peptidase
FZ025_RS19760	COG0583	DNA-binding transcription factor activity
FZ025_RS19775	COG3504	Conjugal transfer protein
FZ025_RS19800	COG3451	type IV secretory pathway VirB4
FZ025_RS19810	COG3838	Conjugal transfer protein Trbc
FZ025_RS19815	COG4962	Type ii secretion system protein e
FZ025_RS19865	COG1566	PFAM secretion protein HlyD family protein
FZ025_RS19880	COG0583	DNA-binding transcription factor activity
FZ025_RS19925	COG0583	DNA-binding transcription factor activity
FZ025_RS19930	COG2807	transmembrane transport
FZ025_RS19955	COG0477	Major facilitator Superfamily
FZ025_RS19960	COG1309	transcriptional regulator
FZ025_RS19975	COG0640	Transcriptional regulator
FZ025_RS19985	COG2814	Major facilitator Superfamily
FZ025_RS19990	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS19995	COG0583	DNA-binding transcription factor activity
FZ025_RS20010	COG4959	Type IV secretory pathway protease TraF
FZ025_RS20025	COG1192	Involved in chromosome partitioning
FZ025_RS20035	COG5489	Protein of unknown function (DUF736)
FZ025_RS20040	COG1309	transcriptional regulator
FZ025_RS20045	COG2814	Major facilitator Superfamily
FZ025_RS20080	COG2003	Belongs to the UPF0758 family
FZ025_RS20265	COG1074	ATP-dependent DNA helicase activity
FZ025_RS20275	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS20320	COG2165	general secretion pathway protein
FZ025_RS20325	COG1450	Type ii and iii secretion system protein
FZ025_RS20355	COG1459	type II secretion system
FZ025_RS20375	COG3209	COG3209 Rhs family protein
FZ025_RS20425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZ025_RS20430	COG2311	Membrane
FZ025_RS20435	COG1047	Peptidyl-prolyl cis-trans
FZ025_RS20440	COG0791	NLP P60 protein
FZ025_RS20445	COG0791	NLP P60 protein
FZ025_RS20450	COG1607	acyl-coa hydrolase
FZ025_RS20460	COG1301	dicarboxylic acid transport
FZ025_RS20465	COG1785	Belongs to the alkaline phosphatase family
FZ025_RS20475	COG0037	tRNA processing
FZ025_RS20480	COG1722	exodeoxyribonuclease VII activity
FZ025_RS20485	COG0142	geranyltranstransferase activity
FZ025_RS20505	COG0312	modulator of DNA gyrase
FZ025_RS20515	COG0312	modulator of DNA gyrase
FZ025_RS20525	COG1530	ribonuclease E activity
FZ025_RS20535	COG2968	Membrane
FZ025_RS20545	COG4206	TonB-dependent receptor
FZ025_RS20565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FZ025_RS20580	COG0495	leucyl-tRNA aminoacylation
FZ025_RS20590	COG3118	belongs to the thioredoxin family
FZ025_RS20600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FZ025_RS20620	COG0346	lactoylglutathione lyase activity
FZ025_RS20640	COG2878	Part of a membrane complex involved in electron transport
FZ025_RS20655	COG1595	DNA-templated transcription, initiation
FZ025_RS20690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FZ025_RS20710	COG0251	oxidation-reduction process
FZ025_RS20720	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FZ025_RS20720	COG0392	lysyltransferase activity
FZ025_RS20750	COG2814	Major facilitator Superfamily
FZ025_RS20755	COG0583	DNA-binding transcription factor activity
FZ025_RS20770	COG2824	Alkylphosphonate utilization operon protein PhnA
FZ025_RS20780	COG1047	Peptidyl-prolyl cis-trans
FZ025_RS20785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FZ025_RS20810	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS20840	COG2826	transposase and inactivated derivatives, IS30 family
FZ025_RS20900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FZ025_RS20915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FZ025_RS20950	COG1451	nucleotide metabolic process
FZ025_RS20980	COG1703	isobutyryl-CoA mutase activity
FZ025_RS20980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZ025_RS20980	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZ025_RS21010	COG0745	RESPONSE REGULATOR receiver
FZ025_RS21010	COG3706	GGDEF domain
FZ025_RS21025	COG1960	acyl-CoA dehydrogenase activity
FZ025_RS21030	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FZ025_RS21030	COG1793	dna ligase
FZ025_RS21035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FZ025_RS21035	COG1793	dna ligase
FZ025_RS21040	COG1201	RNA secondary structure unwinding
FZ025_RS21090	COG2080	2 iron, 2 sulfur cluster binding
FZ025_RS21095	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FZ025_RS21100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FZ025_RS21105	COG0746	molybdenum cofactor guanylyltransferase activity
FZ025_RS21120	COG3214	Protein conserved in bacteria
FZ025_RS21130	COG1538	Outer membrane efflux protein
FZ025_RS21135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZ025_RS21145	COG1309	transcriptional regulator
FZ025_RS21155	COG0735	belongs to the Fur family
FZ025_RS21185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FZ025_RS21195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FZ025_RS21205	COG0643	Histidine kinase
FZ025_RS21205	COG2198	Histidine kinase
FZ025_RS21210	COG0840	transmembrane signaling receptor activity
FZ025_RS21215	COG0835	chemotaxis
FZ025_RS21220	COG3706	GGDEF domain
FZ025_RS21220	COG5001	Diguanylate cyclase
FZ025_RS21220	COG4251	negative regulation of phosphorylation
FZ025_RS21220	COG2203	Gaf domain
FZ025_RS21255	COG1741	Belongs to the pirin family
FZ025_RS21270	COG1966	Carbon starvation protein
FZ025_RS21275	COG2879	small protein
FZ025_RS21280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FZ025_RS21300	COG0823	Involved in the tonB-independent uptake of proteins
FZ025_RS21300	COG1506	peptidase
FZ025_RS21305	COG1297	OPT oligopeptide transporter protein
FZ025_RS21310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZ025_RS21330	COG3152	Membrane
FZ025_RS21345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FZ025_RS21350	COG1845	cytochrome c oxidase, subunit III
FZ025_RS21355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FZ025_RS21365	COG2964	Protein conserved in bacteria
FZ025_RS21375	COG4771	TonB-dependent receptor
FZ025_RS21400	COG0251	oxidation-reduction process
FZ025_RS21410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZ025_RS21425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FZ025_RS21440	COG0196	riboflavin kinase activity
FZ025_RS21445	COG0728	peptidoglycan biosynthetic process
FZ025_RS21460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FZ025_RS21465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FZ025_RS21470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FZ025_RS21475	COG0824	Thioesterase
FZ025_RS21485	COG1946	Acyl-CoA thioesterase
FZ025_RS21500	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FZ025_RS21510	COG3243	poly(R)-hydroxyalkanoic acid synthase
FZ025_RS21520	COG1183	phosphatidylcholine synthase activity
FZ025_RS21525	COG1028	Short-chain dehydrogenase reductase Sdr
FZ025_RS21540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FZ025_RS21565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FZ025_RS21680	COG3701	Conjugal transfer protein
FZ025_RS21685	COG3451	type IV secretory pathway VirB4
FZ025_RS21690	COG5268	conjugation
FZ025_RS21695	COG3838	Conjugal transfer protein Trbc
FZ025_RS21700	COG4962	Type ii secretion system protein e