locus-tag	class	description
EBA18_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EBA18_RS00030	COG0187	DNA topoisomerase II activity
EBA18_RS00040	COG0501	Belongs to the peptidase M48B family
EBA18_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EBA18_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA18_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EBA18_RS00100	COG4772	TonB-dependent receptor
EBA18_RS00115	COG3039	Transposase
EBA18_RS00120	COG1304	FMN binding
EBA18_RS00140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EBA18_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA18_RS00245	COG2826	transposase and inactivated derivatives, IS30 family
EBA18_RS00270	COG3039	Transposase
EBA18_RS00280	COG1090	epimerase
EBA18_RS00290	COG0642	Histidine kinase
EBA18_RS00300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBA18_RS00405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EBA18_RS00495	COG3264	Mechanosensitive ion channel
EBA18_RS00495	COG1511	domain protein
EBA18_RS00510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EBA18_RS00520	COG2354	Protein conserved in bacteria
EBA18_RS00525	COG1649	PFAM Uncharacterised BCR, COG1649
EBA18_RS00545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EBA18_RS00570	COG0702	epimerase
EBA18_RS00585	COG1858	cytochrome C peroxidase
EBA18_RS00670	COG0513	Belongs to the DEAD box helicase family
EBA18_RS00680	COG3039	Transposase
EBA18_RS00730	COG1136	(ABC) transporter
EBA18_RS00765	COG1136	(ABC) transporter
EBA18_RS00810	COG1272	protein, Hemolysin III
EBA18_RS00815	COG1111	helicase
EBA18_RS00815	COG1205	dead DEAH box helicase
EBA18_RS00875	COG0067	glutamate synthase
EBA18_RS00875	COG0069	glutamate synthase activity
EBA18_RS00875	COG0070	glutamate synthase
EBA18_RS00880	COG0493	'glutamate synthase
EBA18_RS00925	COG1609	Transcriptional regulator
EBA18_RS00960	COG0366	Alpha amylase catalytic
EBA18_RS00965	COG0366	Alpha amylase catalytic
EBA18_RS01015	COG0606	chelatase, subunit chli
EBA18_RS01065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EBA18_RS01070	COG1166	arginine decarboxylase activity
EBA18_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EBA18_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS01175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EBA18_RS01190	COG0210	DNA helicase
EBA18_RS01205	COG3132	Protein of unknown function, DUF480
EBA18_RS01210	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EBA18_RS01215	COG0284	orotidine-5'-phosphate decarboxylase activity
EBA18_RS01250	COG2937	Belongs to the GPAT DAPAT family
EBA18_RS01290	COG1752	Esterase of the alpha-beta hydrolase superfamily
EBA18_RS01300	COG1119	ATPase activity
EBA18_RS01315	COG1125	glycine betaine transport
EBA18_RS01315	COG0517	IMP dehydrogenase activity
EBA18_RS01330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EBA18_RS01335	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EBA18_RS01340	COG3550	peptidyl-serine autophosphorylation
EBA18_RS01345	COG1396	sequence-specific DNA binding
EBA18_RS01365	COG0489	protein tyrosine kinase activity
EBA18_RS01370	COG2062	phosphohistidine phosphatase, SixA
EBA18_RS01380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA18_RS01425	COG1968	undecaprenyl-diphosphatase activity
EBA18_RS01430	COG0174	glutamine synthetase
EBA18_RS01435	COG0347	Belongs to the P(II) protein family
EBA18_RS01440	COG0004	ammonium transporteR
EBA18_RS01445	COG3852	Histidine kinase
EBA18_RS01450	COG2204	response regulator
EBA18_RS01455	COG2032	superoxide dismutase activity
EBA18_RS01460	COG2032	superoxide dismutase activity
EBA18_RS01495	COG1196	nuclear chromosome segregation
EBA18_RS01505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EBA18_RS01510	COG1074	ATP-dependent DNA helicase activity
EBA18_RS01520	COG3549	Plasmid maintenance system killer
EBA18_RS01610	COG1764	response to oxidative stress
EBA18_RS01615	COG1846	Transcriptional regulator
EBA18_RS01655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EBA18_RS01695	COG2211	Major facilitator Superfamily
EBA18_RS01720	COG3693	PFAM glycoside hydrolase, family 10
EBA18_RS01745	COG0246	Mannitol dehydrogenase
EBA18_RS01750	COG1472	Belongs to the glycosyl hydrolase 3 family
EBA18_RS01760	COG4948	Mandelate Racemase Muconate Lactonizing
EBA18_RS01770	COG3661	Belongs to the glycosyl hydrolase 67 family
EBA18_RS01790	COG0037	tRNA processing
EBA18_RS01795	COG2974	May be involved in recombination
EBA18_RS01820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EBA18_RS01830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBA18_RS01840	COG0805	protein transport
EBA18_RS01850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EBA18_RS01850	COG0519	Catalyzes the synthesis of GMP from XMP
EBA18_RS01875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EBA18_RS01880	COG0752	glycyl-tRNA synthetase alpha subunit
EBA18_RS01890	COG0457	Tetratricopeptide repeat
EBA18_RS01895	COG4771	TonB-dependent receptor
EBA18_RS01920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EBA18_RS01930	COG0697	spore germination
EBA18_RS01940	COG0523	cobalamin synthesis protein
EBA18_RS01990	COG1960	acyl-CoA dehydrogenase activity
EBA18_RS01995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EBA18_RS02000	COG4770	biotin carboxylase activity
EBA18_RS02055	COG2072	flavoprotein involved in K transport
EBA18_RS02075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EBA18_RS02120	COG0084	hydrolase, TatD family'
EBA18_RS02140	COG0583	DNA-binding transcription factor activity
EBA18_RS02165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EBA18_RS02170	COG1902	pentaerythritol trinitrate reductase activity
EBA18_RS02200	COG0745	RESPONSE REGULATOR receiver
EBA18_RS02220	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EBA18_RS02225	COG0583	DNA-binding transcription factor activity
EBA18_RS02255	COG0702	epimerase
EBA18_RS02260	COG1733	regulation of RNA biosynthetic process
EBA18_RS02310	COG3039	Transposase
EBA18_RS02340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EBA18_RS02355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBA18_RS02390	COG2911	Protein conserved in bacteria
EBA18_RS02395	COG0729	surface antigen
EBA18_RS02410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EBA18_RS02415	COG3118	belongs to the thioredoxin family
EBA18_RS02425	COG2884	Cell division ATP-binding protein ftsE
EBA18_RS02430	COG2177	Part of the ABC transporter FtsEX involved in
EBA18_RS02435	COG3437	response regulator, receiver
EBA18_RS02440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EBA18_RS02445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EBA18_RS02455	COG1252	NADH dehydrogenase
EBA18_RS02480	COG0459	protein refolding
EBA18_RS02490	COG4771	TonB-dependent receptor
EBA18_RS02505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EBA18_RS02550	COG3386	PFAM SMP-30 Gluconolaconase
EBA18_RS02565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EBA18_RS02595	COG2353	YceI-like domain
EBA18_RS02705	COG0408	coproporphyrinogen oxidase activity
EBA18_RS02715	COG3039	Transposase
EBA18_RS02740	COG0129	dihydroxy-acid dehydratase activity
EBA18_RS02750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EBA18_RS02790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EBA18_RS02795	COG0318	PFAM AMP-dependent synthetase and ligase
EBA18_RS02800	COG0727	PFAM Uncharacterised protein family (UPF0153)
EBA18_RS02805	COG0596	Alpha beta hydrolase
EBA18_RS02820	COG3177	Filamentation induced by cAMP protein fic
EBA18_RS02825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBA18_RS02840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EBA18_RS02865	COG4191	Histidine kinase
EBA18_RS02870	COG0028	Belongs to the TPP enzyme family
EBA18_RS02885	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EBA18_RS02890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBA18_RS02920	COG5383	Protein conserved in bacteria
EBA18_RS02935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA18_RS02940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA18_RS02945	COG1473	amidohydrolase
EBA18_RS02955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EBA18_RS02955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EBA18_RS02970	COG3328	transposase activity
EBA18_RS02995	COG3039	Transposase
EBA18_RS03070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EBA18_RS03085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBA18_RS03090	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EBA18_RS03100	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EBA18_RS03105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EBA18_RS03110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EBA18_RS03160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EBA18_RS03175	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EBA18_RS03235	COG3039	Transposase
EBA18_RS03260	COG1294	oxidase, subunit
EBA18_RS03265	COG1271	oxidase subunit
EBA18_RS03280	COG2204	response regulator
EBA18_RS03330	COG2972	Histidine kinase
EBA18_RS03345	COG0531	amino acid
EBA18_RS03365	COG3590	peptidase
EBA18_RS03380	COG0667	Aldo Keto reductase
EBA18_RS03395	COG3384	dioxygenase
EBA18_RS03405	COG1573	uracil-dna glycosylase
EBA18_RS03415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EBA18_RS03425	COG0025	NhaP-type Na H and K H
EBA18_RS03430	COG1131	(ABC) transporter
EBA18_RS03435	COG0842	Transport permease protein
EBA18_RS03450	COG1404	Belongs to the peptidase S8 family
EBA18_RS03465	COG0745	RESPONSE REGULATOR receiver
EBA18_RS03515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA18_RS03540	COG2205	protein histidine kinase activity
EBA18_RS03540	COG2202	Pas domain
EBA18_RS03570	COG2813	Specifically methylates the guanine in position
EBA18_RS03575	COG1187	pseudouridine synthase activity
EBA18_RS03580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EBA18_RS03620	COG0697	spore germination
EBA18_RS03630	COG2011	ABC-type metal ion transport system permease component
EBA18_RS03660	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBA18_RS03670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBA18_RS03690	COG0356	it plays a direct role in the translocation of protons across the membrane
EBA18_RS03700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EBA18_RS03710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EBA18_RS03715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EBA18_RS03720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EBA18_RS03775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA18_RS03780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBA18_RS03830	COG0339	signal peptide processing
EBA18_RS03870	COG1956	GAF domain-containing protein
EBA18_RS03875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EBA18_RS03885	COG0720	synthase
EBA18_RS03895	COG0513	Belongs to the DEAD box helicase family
EBA18_RS03910	COG0625	glutathione transferase activity
EBA18_RS03940	COG0626	cystathionine gamma-synthase activity
EBA18_RS03960	COG1216	Glycosyl transferase, family 2
EBA18_RS03960	COG0438	transferase activity, transferring glycosyl groups
EBA18_RS03995	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EBA18_RS04000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EBA18_RS04015	COG0277	FAD linked oxidase domain protein
EBA18_RS04020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EBA18_RS04020	COG0546	phosphoglycolate phosphatase activity
EBA18_RS04035	COG2086	electron transfer activity
EBA18_RS04060	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EBA18_RS04060	COG0662	Cupin 2, conserved barrel domain protein
EBA18_RS04065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBA18_RS04105	COG3218	ABC-type transport auxiliary lipoprotein component
EBA18_RS04105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EBA18_RS04110	COG1127	ABC transporter
EBA18_RS04115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EBA18_RS04130	COG0442	prolyl-tRNA aminoacylation
EBA18_RS04140	COG1183	phosphatidylcholine synthase activity
EBA18_RS04175	COG3039	Transposase
EBA18_RS04200	COG3039	Transposase
EBA18_RS04230	COG0525	valine-tRNA ligase activity
EBA18_RS04245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EBA18_RS04255	COG0795	lipopolysaccharide-transporting ATPase activity
EBA18_RS04270	COG4974	Belongs to the 'phage' integrase family
EBA18_RS04275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EBA18_RS04280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EBA18_RS04280	COG0047	phosphoribosylformylglycinamidine synthase activity
EBA18_RS04290	COG5295	Hep Hag repeat protein
EBA18_RS04300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EBA18_RS04310	COG1459	type II secretion system
EBA18_RS04315	COG2165	general secretion pathway protein
EBA18_RS04320	COG4970	Tfp pilus assembly protein FimT
EBA18_RS04325	COG2165	general secretion pathway protein
EBA18_RS04330	COG4795	General secretion pathway protein
EBA18_RS04335	COG3156	type II secretion system protein K
EBA18_RS04340	COG3166	PFAM Fimbrial assembly family protein
EBA18_RS04355	COG1450	Type ii and iii secretion system protein
EBA18_RS04370	COG2188	Transcriptional regulator
EBA18_RS04425	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EBA18_RS04430	COG1518	maintenance of DNA repeat elements
EBA18_RS04475	COG1399	metal-binding, possibly nucleic acid-binding protein
EBA18_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS04505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EBA18_RS04515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EBA18_RS04520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EBA18_RS04555	COG3829	transcription factor binding
EBA18_RS04610	COG3039	Transposase
EBA18_RS04640	COG2826	transposase and inactivated derivatives, IS30 family
EBA18_RS04650	COG0678	peroxiredoxin activity
EBA18_RS04670	COG0330	HflC and HflK could
EBA18_RS04675	COG0330	HflC and HflK could
EBA18_RS04685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EBA18_RS04690	COG0308	aminopeptidase N
EBA18_RS04745	COG1560	Kdo2-lipid A biosynthetic process
EBA18_RS04750	COG1519	Transferase
EBA18_RS04755	COG1538	Outer membrane efflux protein
EBA18_RS04760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBA18_RS04790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EBA18_RS04795	COG0066	3-isopropylmalate dehydratase activity
EBA18_RS04830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EBA18_RS04840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EBA18_RS04845	COG3710	Transcriptional regulator
EBA18_RS04870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EBA18_RS04890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EBA18_RS04920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBA18_RS04930	COG3781	membrane
EBA18_RS05095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EBA18_RS05115	COG1217	gtp-binding protein TYPA
EBA18_RS05120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EBA18_RS05125	COG0039	L-malate dehydrogenase activity
EBA18_RS05130	COG0625	glutathione transferase activity
EBA18_RS05165	COG3039	Transposase
EBA18_RS05190	COG0584	glycerophosphoryl diester phosphodiesterase
EBA18_RS05220	COG1902	pentaerythritol trinitrate reductase activity
EBA18_RS05220	COG0446	pyridine nucleotide-disulphide oxidoreductase
EBA18_RS05225	COG0604	alcohol dehydrogenase
EBA18_RS05255	COG0156	8-amino-7-oxononanoate synthase activity
EBA18_RS05260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EBA18_RS05265	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EBA18_RS05270	COG4208	sulfate ABC transporter
EBA18_RS05275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EBA18_RS05315	COG0588	phosphoglycerate mutase activity
EBA18_RS05325	COG0285	dihydrofolate synthase activity
EBA18_RS05345	COG2833	Protein of unknown function (DUF455)
EBA18_RS05365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBA18_RS05370	COG0671	phosphoesterase, PA-phosphatase related
EBA18_RS05375	COG0438	transferase activity, transferring glycosyl groups
EBA18_RS05385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EBA18_RS05400	COG4783	chaperone-mediated protein folding
EBA18_RS05425	COG0473	3-isopropylmalate dehydrogenase activity
EBA18_RS05480	COG0544	peptidyl-prolyl cis-trans isomerase activity
EBA18_RS05520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBA18_RS05545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EBA18_RS05555	COG0631	protein serine/threonine phosphatase activity
EBA18_RS05610	COG0582	viral genome integration into host DNA
EBA18_RS05620	COG0859	PFAM glycosyl transferase family 9
EBA18_RS05625	COG3642	lipopolysaccharide core region biosynthetic process
EBA18_RS05630	COG1234	tRNA 3'-trailer cleavage
EBA18_RS05635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EBA18_RS05645	COG0315	cyclic pyranopterin monophosphate synthase activity
EBA18_RS05650	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EBA18_RS05655	COG0314	molybdopterin synthase activity
EBA18_RS05685	COG0537	adenosine 5'-monophosphoramidase activity
EBA18_RS05705	COG0714	Associated with various cellular activities
EBA18_RS05725	COG0242	peptide deformylase activity
EBA18_RS05780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EBA18_RS05785	COG0726	polysaccharide deacetylase
EBA18_RS05810	COG1162	GTPase activity
EBA18_RS05835	COG2211	Major facilitator Superfamily
EBA18_RS05845	COG1609	Transcriptional regulator
EBA18_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS05855	COG2851	Citrate transporter
EBA18_RS05875	COG0642	Histidine kinase
EBA18_RS05885	COG2197	response regulator
EBA18_RS05905	COG0583	DNA-binding transcription factor activity
EBA18_RS05920	COG4191	Histidine kinase
EBA18_RS05940	COG0281	malic enzyme
EBA18_RS05940	COG0280	phosphate acetyltransferase
EBA18_RS06005	COG0352	thiamine-phosphate diphosphorylase activity
EBA18_RS06010	COG1773	rubredoxin
EBA18_RS06015	COG2912	Transglutaminase-like superfamily
EBA18_RS06025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EBA18_RS06035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EBA18_RS06060	COG0006	proline dipeptidase activity
EBA18_RS06090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EBA18_RS06105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EBA18_RS06110	COG1561	YicC-like family, N-terminal region
EBA18_RS06135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EBA18_RS06145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EBA18_RS06170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EBA18_RS06220	COG0714	Associated with various cellular activities
EBA18_RS06240	COG2304	oxidoreductase activity
EBA18_RS06260	COG1301	dicarboxylic acid transport
EBA18_RS06265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EBA18_RS06275	COG0739	heme binding
EBA18_RS06280	COG1376	ErfK ybiS ycfS ynhG family protein
EBA18_RS06305	COG1022	Amp-dependent synthetase and ligase
EBA18_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS06330	COG0642	Histidine kinase
EBA18_RS06350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EBA18_RS06355	COG4149	molybdate abc transporter
EBA18_RS06360	COG0725	ABC transporter, periplasmic molybdate-binding protein
EBA18_RS06365	COG3453	Protein conserved in bacteria
EBA18_RS06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBA18_RS06400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EBA18_RS06420	COG2205	protein histidine kinase activity
EBA18_RS06425	COG0745	RESPONSE REGULATOR receiver
EBA18_RS06450	COG3039	Transposase
EBA18_RS06485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBA18_RS06490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EBA18_RS06535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EBA18_RS06565	COG2201	protein-glutamate methylesterase activity
EBA18_RS06640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EBA18_RS06650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EBA18_RS06655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EBA18_RS06670	COG1842	Phage shock protein A
EBA18_RS06695	COG0754	glutathionylspermidine amidase activity
EBA18_RS06765	COG0531	amino acid
EBA18_RS06770	COG2197	response regulator
EBA18_RS06785	COG1113	amino acid transport
EBA18_RS06805	COG1271	oxidase subunit
EBA18_RS06810	COG1294	oxidase, subunit
EBA18_RS06820	COG2239	Acts as a magnesium transporter
EBA18_RS06830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBA18_RS06835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBA18_RS06845	COG1660	Displays ATPase and GTPase activities
EBA18_RS06850	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EBA18_RS06855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBA18_RS06870	COG1137	ATPase activity
EBA18_RS06875	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EBA18_RS06885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EBA18_RS06895	COG0271	Belongs to the BolA IbaG family
EBA18_RS06900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EBA18_RS06920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EBA18_RS06935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EBA18_RS06945	COG0628	permease
EBA18_RS06955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EBA18_RS06960	COG3178	'Phosphotransferase
EBA18_RS06975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBA18_RS06980	COG1555	photosystem II stabilization
EBA18_RS07025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EBA18_RS07040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EBA18_RS07065	COG0228	four-way junction DNA binding
EBA18_RS07070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EBA18_RS07075	COG0336	Belongs to the RNA methyltransferase TrmD family
EBA18_RS07090	COG0534	Mate efflux family protein
EBA18_RS07110	COG3039	Transposase
EBA18_RS07140	COG0542	response to heat
EBA18_RS07180	COG4206	TonB-dependent receptor
EBA18_RS07240	COG0019	diaminopimelate decarboxylase activity
EBA18_RS07250	COG2814	Major facilitator Superfamily
EBA18_RS07255	COG4264	IucA IucC family
EBA18_RS07265	COG4772	TonB-dependent receptor
EBA18_RS07280	COG4651	solute:proton antiporter activity
EBA18_RS07280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EBA18_RS07305	COG0488	(ABC) transporter
EBA18_RS07330	COG0657	acetylesterase activity
EBA18_RS07330	COG2755	lipolytic protein G-D-S-L family
EBA18_RS07350	COG2207	Transcriptional regulator
EBA18_RS07355	COG0326	Molecular chaperone. Has ATPase activity
EBA18_RS07385	COG3328	transposase activity
EBA18_RS07390	COG0174	glutamine synthetase
EBA18_RS07395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EBA18_RS07405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EBA18_RS07420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EBA18_RS07455	COG2146	nitrite reductase [NAD(P)H] activity
EBA18_RS07470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EBA18_RS07475	COG0719	Fe-S assembly protein
EBA18_RS07480	COG0396	ATPase activity
EBA18_RS07485	COG0719	Fe-S assembly protein
EBA18_RS07490	COG1959	2 iron, 2 sulfur cluster binding
EBA18_RS07510	COG0693	protein deglycase activity
EBA18_RS07550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EBA18_RS07585	COG0519	Catalyzes the synthesis of GMP from XMP
EBA18_RS07595	COG1678	Uncharacterized ACR, COG1678
EBA18_RS07600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EBA18_RS07615	COG1764	response to oxidative stress
EBA18_RS07625	COG0384	phenazine biosynthesis protein PhzF
EBA18_RS07635	COG0527	aspartate kinase activity
EBA18_RS07665	COG0142	geranyltranstransferase activity
EBA18_RS07670	COG0629	single-stranded DNA binding
EBA18_RS07675	COG4251	negative regulation of phosphorylation
EBA18_RS07675	COG5001	Diguanylate cyclase
EBA18_RS07675	COG2203	Gaf domain
EBA18_RS07675	COG3706	GGDEF domain
EBA18_RS07715	COG2879	small protein
EBA18_RS07720	COG1966	Carbon starvation protein
EBA18_RS07725	COG1741	Belongs to the pirin family
EBA18_RS07780	COG3179	chitinase
EBA18_RS07800	COG3039	Transposase
EBA18_RS07930	COG2890	protein-(glutamine-N5) methyltransferase activity
EBA18_RS07935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EBA18_RS07940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EBA18_RS07945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EBA18_RS07965	COG0101	tRNA pseudouridine synthase activity
EBA18_RS07970	COG0135	phosphoribosylanthranilate isomerase activity
EBA18_RS07980	COG0133	tryptophan synthase activity
EBA18_RS07990	COG0159	tryptophan synthase activity
EBA18_RS08000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EBA18_RS08005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBA18_RS08055	COG0149	triose-phosphate isomerase activity
EBA18_RS08070	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBA18_RS08080	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBA18_RS08085	COG0649	NAD binding
EBA18_RS08090	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EBA18_RS08095	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EBA18_RS08100	COG1034	ATP synthesis coupled electron transport
EBA18_RS08105	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EBA18_RS08135	COG1007	ATP synthesis coupled electron transport
EBA18_RS08145	COG0779	Required for maturation of 30S ribosomal subunits
EBA18_RS08150	COG0195	Participates in both transcription termination and antitermination
EBA18_RS08170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EBA18_RS08175	COG1185	polyribonucleotide nucleotidyltransferase activity
EBA18_RS08210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EBA18_RS08220	COG2095	MarC family integral membrane protein
EBA18_RS08235	COG1611	Belongs to the LOG family
EBA18_RS08285	COG4969	Belongs to the N-Me-Phe pilin family
EBA18_RS08290	COG0556	nucleotide-excision repair
EBA18_RS08325	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EBA18_RS08335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EBA18_RS08340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EBA18_RS08395	COG0438	transferase activity, transferring glycosyl groups
EBA18_RS08400	COG0438	transferase activity, transferring glycosyl groups
EBA18_RS08410	COG0438	transferase activity, transferring glycosyl groups
EBA18_RS08450	COG3040	lipid binding
EBA18_RS08550	COG0784	Response regulator, receiver
EBA18_RS08550	COG4191	Histidine kinase
EBA18_RS08575	COG0552	protein localization to endoplasmic reticulum
EBA18_RS08585	COG3938	Belongs to the proline racemase family
EBA18_RS08590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA18_RS08605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBA18_RS08615	COG0006	proline dipeptidase activity
EBA18_RS08630	COG0531	amino acid
EBA18_RS08680	COG4206	TonB-dependent receptor
EBA18_RS08750	COG3039	Transposase
EBA18_RS08775	COG0746	molybdenum cofactor guanylyltransferase activity
EBA18_RS08800	COG1648	precorrin-2 dehydrogenase activity
EBA18_RS08800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBA18_RS08830	COG3039	Transposase
EBA18_RS08865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EBA18_RS08885	COG1054	Belongs to the UPF0176 family
EBA18_RS08905	COG1530	ribonuclease E activity
EBA18_RS08915	COG3064	Membrane
EBA18_RS08920	COG0428	transporter
EBA18_RS08925	COG0428	transporter
EBA18_RS08935	COG2154	pterin-4-alpha-carbinolamine dehydratase
EBA18_RS08940	COG0316	Belongs to the HesB IscA family
EBA18_RS08940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EBA18_RS08965	COG3039	Transposase
EBA18_RS08970	COG3039	Transposase
EBA18_RS09005	COG3039	Transposase
EBA18_RS09120	COG0631	protein serine/threonine phosphatase activity
EBA18_RS09125	COG0515	serine threonine protein kinase
EBA18_RS09155	COG1858	cytochrome C peroxidase
EBA18_RS09210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA18_RS09215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA18_RS09235	COG2201	protein-glutamate methylesterase activity
EBA18_RS09250	COG2201	protein-glutamate methylesterase activity
EBA18_RS09265	COG2201	protein-glutamate methylesterase activity
EBA18_RS09295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBA18_RS09315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EBA18_RS09330	COG1595	DNA-templated transcription, initiation
EBA18_RS09380	COG2244	polysaccharide biosynthetic process
EBA18_RS09410	COG2264	protein methyltransferase activity
EBA18_RS09420	COG0438	transferase activity, transferring glycosyl groups
EBA18_RS09435	COG1136	(ABC) transporter
EBA18_RS09440	COG1132	(ABC) transporter
EBA18_RS09450	COG0477	Major facilitator Superfamily
EBA18_RS09470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EBA18_RS09485	COG1253	flavin adenine dinucleotide binding
EBA18_RS09500	COG0306	phosphate transporter
EBA18_RS09530	COG0504	CTP synthase activity
EBA18_RS09535	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EBA18_RS09545	COG0148	phosphopyruvate hydratase activity
EBA18_RS09550	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EBA18_RS09555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EBA18_RS09565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EBA18_RS09580	COG2840	Smr protein MutS2
EBA18_RS09585	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EBA18_RS09590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBA18_RS09595	COG1238	metal cluster binding
EBA18_RS09610	COG1534	Rna-binding protein
EBA18_RS09615	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EBA18_RS09625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EBA18_RS09630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EBA18_RS09640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EBA18_RS09645	COG1546	Belongs to the CinA family
EBA18_RS09660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EBA18_RS09665	COG2137	regulation of response to DNA damage stimulus
EBA18_RS09670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EBA18_RS09675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EBA18_RS09700	COG0305	Participates in initiation and elongation during chromosome replication
EBA18_RS09705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EBA18_RS09730	COG1741	Belongs to the pirin family
EBA18_RS09735	COG0583	DNA-binding transcription factor activity
EBA18_RS09765	COG0351	phosphomethylpyrimidine kinase
EBA18_RS09775	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EBA18_RS09780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EBA18_RS09795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBA18_RS09805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EBA18_RS09810	COG3734	2-keto-3-deoxy-galactonokinase
EBA18_RS09820	COG4948	Mandelate Racemase Muconate Lactonizing
EBA18_RS09825	COG0800	Aldolase
EBA18_RS09840	COG1501	Belongs to the glycosyl hydrolase 31 family
EBA18_RS09850	COG1070	Carbohydrate kinase
EBA18_RS09860	COG0477	Major facilitator Superfamily
EBA18_RS09880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EBA18_RS09930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EBA18_RS09935	COG2258	MOSC domain
EBA18_RS09945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EBA18_RS09950	COG0505	Belongs to the CarA family
EBA18_RS09960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EBA18_RS09965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBA18_RS09975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EBA18_RS10035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EBA18_RS10050	COG2198	Histidine kinase
EBA18_RS10050	COG0784	Response regulator, receiver
EBA18_RS10050	COG2205	protein histidine kinase activity
EBA18_RS10055	COG1024	Enoyl-CoA hydratase
EBA18_RS10060	COG0318	PFAM AMP-dependent synthetase and ligase
EBA18_RS10090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EBA18_RS10150	COG0835	chemotaxis
EBA18_RS10170	COG0840	transmembrane signaling receptor activity
EBA18_RS10175	COG0840	transmembrane signaling receptor activity
EBA18_RS10180	COG0840	transmembrane signaling receptor activity
EBA18_RS10185	COG0840	transmembrane signaling receptor activity
EBA18_RS10195	COG0840	transmembrane signaling receptor activity
EBA18_RS10205	COG0840	transmembrane signaling receptor activity
EBA18_RS10220	COG0840	transmembrane signaling receptor activity
EBA18_RS10245	COG0745	RESPONSE REGULATOR receiver
EBA18_RS10255	COG0835	chemotaxis
EBA18_RS10265	COG1360	Flagellar Motor Protein
EBA18_RS10270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EBA18_RS10290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EBA18_RS10300	COG4771	TonB-dependent receptor
EBA18_RS10315	COG1192	Involved in chromosome partitioning
EBA18_RS10355	COG3039	Transposase
EBA18_RS10450	COG3039	Transposase
EBA18_RS10490	COG0343	queuine tRNA-ribosyltransferase activity
EBA18_RS10495	COG1862	Preprotein translocase
EBA18_RS10500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBA18_RS10505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBA18_RS10535	COG3328	transposase activity
EBA18_RS10550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EBA18_RS10560	COG0704	Plays a role in the regulation of phosphate uptake
EBA18_RS10575	COG0573	inorganic phosphate transmembrane transporter activity
EBA18_RS10580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EBA18_RS10615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EBA18_RS10625	COG1024	Enoyl-CoA hydratase
EBA18_RS10635	COG0494	nUDIX hydrolase
EBA18_RS10680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBA18_RS10680	COG0116	Belongs to the methyltransferase superfamily
EBA18_RS10705	COG0667	Aldo Keto reductase
EBA18_RS10715	COG2925	Exonuclease
EBA18_RS10745	COG0288	reversible hydration of carbon dioxide
EBA18_RS10780	COG0316	Belongs to the HesB IscA family
EBA18_RS10785	COG0360	Binds together with S18 to 16S ribosomal RNA
EBA18_RS10795	COG0359	binds to the 23S rRNA
EBA18_RS10805	COG3115	cell septum assembly
EBA18_RS10820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EBA18_RS10835	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EBA18_RS10860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EBA18_RS10870	COG2986	histidine ammonia-lyase
EBA18_RS10875	COG1228	amidohydrolase
EBA18_RS10925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EBA18_RS10935	COG1605	Chorismate mutase
EBA18_RS10935	COG0077	Prephenate dehydratase
EBA18_RS10940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EBA18_RS10970	COG4566	intracellular signal transduction
EBA18_RS11025	COG0860	N-Acetylmuramoyl-L-alanine amidase
EBA18_RS11030	COG1469	GTP cyclohydrolase I activity
EBA18_RS11040	COG0617	tRNA 3'-terminal CCA addition
EBA18_RS11050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EBA18_RS11055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EBA18_RS11090	COG1472	Belongs to the glycosyl hydrolase 3 family
EBA18_RS11110	COG2203	Gaf domain
EBA18_RS11110	COG3706	GGDEF domain
EBA18_RS11110	COG4251	negative regulation of phosphorylation
EBA18_RS11110	COG5001	Diguanylate cyclase
EBA18_RS11200	COG0386	Belongs to the glutathione peroxidase family
EBA18_RS11285	COG1247	-acetyltransferase
EBA18_RS11305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EBA18_RS11335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBA18_RS11350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBA18_RS11355	COG1393	Belongs to the ArsC family
EBA18_RS11360	COG0431	NADPH-dependent FMN reductase
EBA18_RS11365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EBA18_RS11370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBA18_RS11395	COG2205	protein histidine kinase activity
EBA18_RS11395	COG0784	Response regulator, receiver
EBA18_RS11395	COG5002	protein histidine kinase activity
EBA18_RS11430	COG0800	Aldolase
EBA18_RS11435	COG0129	dihydroxy-acid dehydratase activity
EBA18_RS11440	COG0363	glucosamine-6-phosphate deaminase activity
EBA18_RS11450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EBA18_RS11465	COG0354	folic acid binding
EBA18_RS11480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EBA18_RS11495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EBA18_RS11510	COG4591	ABC-type transport system involved in lipoprotein release permease component
EBA18_RS11540	COG0811	peptide transport
EBA18_RS11555	COG1663	tetraacyldisaccharide 4'-kinase activity
EBA18_RS11565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBA18_RS11575	COG0322	excinuclease ABC activity
EBA18_RS11625	COG2801	Transposase and inactivated derivatives
EBA18_RS11680	COG0653	protein targeting
EBA18_RS11845	COG0140	phosphoribosyl-ATP diphosphatase activity
EBA18_RS11845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EBA18_RS11855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EBA18_RS11865	COG0131	Imidazoleglycerol-phosphate dehydratase
EBA18_RS11865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EBA18_RS11880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EBA18_RS11910	COG0124	histidyl-tRNA synthetase
EBA18_RS11930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EBA18_RS11975	COG1012	belongs to the aldehyde dehydrogenase family
EBA18_RS12000	COG0697	spore germination
EBA18_RS12040	COG0671	phosphoesterase, PA-phosphatase related
EBA18_RS12055	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EBA18_RS12070	COG2183	response to ionizing radiation
EBA18_RS12080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA18_RS12080	COG0723	plastoquinol--plastocyanin reductase activity
EBA18_RS12095	COG3243	poly(R)-hydroxyalkanoic acid synthase
EBA18_RS12105	COG1183	phosphatidylcholine synthase activity
EBA18_RS12110	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS12135	COG0668	transmembrane transport
EBA18_RS12155	COG1914	H( )-stimulated, divalent metal cation uptake system
EBA18_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS12205	COG0583	DNA-binding transcription factor activity
EBA18_RS12210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EBA18_RS12215	COG3002	Belongs to the UPF0753 family
EBA18_RS12230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EBA18_RS12260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EBA18_RS12270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBA18_RS12275	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EBA18_RS12285	COG0776	regulation of translation
EBA18_RS12290	COG0539	negative regulation of cytoplasmic translation
EBA18_RS12295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EBA18_RS12310	COG2957	Belongs to the agmatine deiminase family
EBA18_RS12320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBA18_RS12345	COG0395	ABC-type sugar transport system, permease component
EBA18_RS12350	COG1175	transmembrane transport
EBA18_RS12380	COG2350	Protein conserved in bacteria
EBA18_RS12385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EBA18_RS12390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EBA18_RS12395	COG1187	pseudouridine synthase activity
EBA18_RS12420	COG0436	Aminotransferase
EBA18_RS12425	COG4133	protoheme IX ABC transporter activity
EBA18_RS12480	COG0277	FAD linked oxidase domain protein
EBA18_RS12485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EBA18_RS12495	COG0531	amino acid
EBA18_RS12500	COG0531	amino acid
EBA18_RS12510	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EBA18_RS12540	COG3039	Transposase
EBA18_RS12550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EBA18_RS12625	COG0303	'Molybdopterin
EBA18_RS12635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA18_RS12655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EBA18_RS12670	COG1250	3-hydroxyacyl-CoA dehydrogenase
EBA18_RS12670	COG1024	Enoyl-CoA hydratase
EBA18_RS12675	COG0183	Belongs to the thiolase family
EBA18_RS12685	COG0038	chloride channel
EBA18_RS12705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EBA18_RS12730	COG1674	ftsk spoiiie
EBA18_RS12735	COG0492	ferredoxin-NADP+ reductase activity
EBA18_RS12760	COG0542	response to heat
EBA18_RS12775	COG0482	sulfurtransferase activity
EBA18_RS12800	COG5001	Diguanylate cyclase
EBA18_RS12805	COG4585	Histidine kinase
EBA18_RS12815	COG5002	protein histidine kinase activity
EBA18_RS12835	COG0784	Response regulator, receiver
EBA18_RS12835	COG0835	chemotaxis
EBA18_RS12845	COG1558	bacterial-type flagellum-dependent cell motility
EBA18_RS12850	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EBA18_RS12860	COG4787	bacterial-type flagellum-dependent cell motility
EBA18_RS12900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EBA18_RS12905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EBA18_RS12935	COG2201	protein-glutamate methylesterase activity
EBA18_RS12955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBA18_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS13000	COG1677	Flagellar hook-basal body complex protein FliE
EBA18_RS13055	COG0643	Histidine kinase
EBA18_RS13055	COG0784	Response regulator, receiver
EBA18_RS13055	COG2198	Histidine kinase
EBA18_RS13085	COG3039	Transposase
EBA18_RS13095	COG3209	COG3209 Rhs family protein
EBA18_RS13195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EBA18_RS13200	COG4988	ABC transporter
EBA18_RS13245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EBA18_RS13265	COG0165	Argininosuccinate lyase
EBA18_RS13280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBA18_RS13285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBA18_RS13295	COG0137	argininosuccinate synthase activity
EBA18_RS13300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EBA18_RS13315	COG2166	iron-sulfur cluster assembly
EBA18_RS13340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EBA18_RS13375	COG3039	Transposase
EBA18_RS13395	COG4677	pectinesterase activity
EBA18_RS13420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EBA18_RS13425	COG0402	S-adenosylhomocysteine deaminase activity
EBA18_RS13440	COG1509	lysine 2,3-aminomutase activity
EBA18_RS13445	COG5001	Diguanylate cyclase
EBA18_RS13445	COG3300	MHYT domain
EBA18_RS13460	COG0483	inositol monophosphate 1-phosphatase activity
EBA18_RS13465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EBA18_RS13490	COG0488	(ABC) transporter
EBA18_RS13495	COG0513	Belongs to the DEAD box helicase family
EBA18_RS13500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EBA18_RS13505	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EBA18_RS13515	COG0625	glutathione transferase activity
EBA18_RS13525	COG1671	Belongs to the UPF0178 family
EBA18_RS13530	COG4681	YaeQ
EBA18_RS13535	COG2081	HI0933 family
EBA18_RS13545	COG0501	Belongs to the peptidase M48B family
EBA18_RS13555	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS13580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EBA18_RS13585	COG0860	N-Acetylmuramoyl-L-alanine amidase
EBA18_RS13590	COG0802	atpase or kinase
EBA18_RS13595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EBA18_RS13595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EBA18_RS13600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EBA18_RS13620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EBA18_RS13710	COG3328	transposase activity
EBA18_RS13755	COG2969	positive regulation of protein catabolic process
EBA18_RS13760	COG0625	glutathione transferase activity
EBA18_RS13765	COG2857	Cytochrome c1
EBA18_RS13770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EBA18_RS13775	COG0723	plastoquinol--plastocyanin reductase activity
EBA18_RS13785	COG0741	lytic transglycosylase activity
EBA18_RS13810	COG1702	phosphate starvation-inducible protein PhoH
EBA18_RS13830	COG4535	Mg2 and Co2 transporter CorC
EBA18_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
EBA18_RS13855	COG1177	transmembrane transport
EBA18_RS13865	COG3842	ATPase activity
EBA18_RS13910	COG0174	glutamine synthetase
EBA18_RS13915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA18_RS13925	COG0477	Major facilitator Superfamily
EBA18_RS13935	COG0243	molybdopterin cofactor binding
EBA18_RS13945	COG2223	nitrite transmembrane transporter activity
EBA18_RS13955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EBA18_RS13960	COG1121	(ABC) transporter
EBA18_RS13970	COG2733	membrane
EBA18_RS13975	COG2205	protein histidine kinase activity
EBA18_RS13975	COG5002	protein histidine kinase activity
EBA18_RS13975	COG0784	Response regulator, receiver
EBA18_RS13985	COG3039	Transposase
EBA18_RS13995	COG2902	Dehydrogenase
EBA18_RS14005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA18_RS14010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA18_RS14035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBA18_RS14035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBA18_RS14040	COG1105	Belongs to the carbohydrate kinase PfkB family
EBA18_RS14045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EBA18_RS14045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EBA18_RS14060	COG3039	Transposase
EBA18_RS14070	COG3039	Transposase
EBA18_RS14220	COG0405	Gamma-glutamyltransferase
EBA18_RS14225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EBA18_RS14240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EBA18_RS14245	COG0742	ribosomal rna small subunit methyltransferase
EBA18_RS14325	COG0583	DNA-binding transcription factor activity
EBA18_RS14335	COG3039	Transposase
EBA18_RS14420	COG1278	Cold shock
EBA18_RS14470	COG3039	Transposase
EBA18_RS14485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBA18_RS14500	COG0557	exoribonuclease II activity
EBA18_RS14530	COG1960	acyl-CoA dehydrogenase activity
EBA18_RS14535	COG2226	methyltransferase
EBA18_RS14540	COG1410	methionine synthase
EBA18_RS14540	COG0646	methionine synthase
EBA18_RS14545	COG0646	methionine synthase
EBA18_RS14545	COG1410	methionine synthase
EBA18_RS14555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA18_RS14565	COG1609	Transcriptional regulator
EBA18_RS14580	COG2900	Belongs to the SlyX family
EBA18_RS14595	COG0386	Belongs to the glutathione peroxidase family
EBA18_RS14605	COG1725	Transcriptional regulator
EBA18_RS14610	COG1131	(ABC) transporter
EBA18_RS14690	COG2850	peptidyl-arginine hydroxylation
EBA18_RS14725	COG1132	(ABC) transporter
EBA18_RS14740	COG0583	DNA-binding transcription factor activity
EBA18_RS14755	COG1605	Chorismate mutase
EBA18_RS14755	COG0287	Prephenate dehydrogenase
EBA18_RS14760	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EBA18_RS14770	COG0484	heat shock protein binding
EBA18_RS14780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EBA18_RS14790	COG0497	DNA recombination
EBA18_RS14800	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA18_RS14810	COG2914	Belongs to the UPF0125 (RnfH) family
EBA18_RS14820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EBA18_RS14835	COG1960	acyl-CoA dehydrogenase activity
EBA18_RS14845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EBA18_RS14890	COG2814	Major facilitator Superfamily
EBA18_RS14895	COG1566	PFAM secretion protein HlyD family protein
EBA18_RS14910	COG2207	Transcriptional regulator
EBA18_RS14945	COG4774	siderophore transport
EBA18_RS14955	COG0367	asparagine synthase
EBA18_RS14970	COG1393	Belongs to the ArsC family
EBA18_RS15030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EBA18_RS15045	COG0233	cytoplasmic translational termination
EBA18_RS15055	COG0575	Belongs to the CDS family
EBA18_RS15065	COG0750	zinc metalloprotease
EBA18_RS15090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBA18_RS15095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBA18_RS15115	COG0825	malonyl-CoA metabolic process
EBA18_RS15125	COG4771	TonB-dependent receptor
EBA18_RS15155	COG1981	membrane
EBA18_RS15200	COG0529	Catalyzes the synthesis of activated sulfate
EBA18_RS15200	COG2895	sulfate adenylyltransferase (ATP) activity
EBA18_RS15240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EBA18_RS15255	COG2040	homocysteine
EBA18_RS15260	COG0833	amino acid
EBA18_RS15280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBA18_RS15280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBA18_RS15290	COG2878	Part of a membrane complex involved in electron transport
EBA18_RS15310	COG1595	DNA-templated transcription, initiation
EBA18_RS15335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EBA18_RS15350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EBA18_RS15355	COG0251	oxidation-reduction process
EBA18_RS15365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EBA18_RS15365	COG0392	lysyltransferase activity
EBA18_RS15410	COG2814	Major facilitator Superfamily
EBA18_RS15415	COG1902	pentaerythritol trinitrate reductase activity
EBA18_RS15430	COG2824	Alkylphosphonate utilization operon protein PhnA
EBA18_RS15445	COG1047	Peptidyl-prolyl cis-trans
EBA18_RS15500	COG3039	Transposase
EBA18_RS15505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EBA18_RS15510	COG3039	Transposase
EBA18_RS15525	COG1451	nucleotide metabolic process
EBA18_RS15550	COG0183	Belongs to the thiolase family
EBA18_RS15580	COG1793	dna ligase
EBA18_RS15580	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EBA18_RS15590	COG1793	dna ligase
EBA18_RS15595	COG1201	RNA secondary structure unwinding
EBA18_RS15615	COG1278	Cold shock
EBA18_RS15620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EBA18_RS15625	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EBA18_RS15635	COG3046	protein related to deoxyribodipyrimidine photolyase
EBA18_RS15640	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
EBA18_RS15645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EBA18_RS15670	COG2954	triphosphatase activity
EBA18_RS15685	COG1381	Involved in DNA repair and RecF pathway recombination
EBA18_RS15715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBA18_RS15730	COG1250	3-hydroxyacyl-CoA dehydrogenase
EBA18_RS15730	COG1024	Enoyl-CoA hydratase
EBA18_RS15750	COG1024	Enoyl-CoA hydratase
EBA18_RS15755	COG1960	acyl-CoA dehydrogenase activity
EBA18_RS15825	COG2353	YceI-like domain
EBA18_RS15835	COG2353	YceI-like domain
EBA18_RS15850	COG1760	l-serine dehydratase
EBA18_RS15860	COG0626	cystathionine gamma-synthase activity
EBA18_RS15865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EBA18_RS15870	COG0739	heme binding
EBA18_RS15875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EBA18_RS15880	COG1272	protein, Hemolysin III
EBA18_RS15900	COG0463	Glycosyl transferase, family 2
EBA18_RS15910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EBA18_RS15920	COG4771	TonB-dependent receptor
EBA18_RS15925	COG1309	transcriptional regulator
EBA18_RS15935	COG1960	acyl-CoA dehydrogenase activity
EBA18_RS15970	COG0509	glycine decarboxylation via glycine cleavage system
EBA18_RS15985	COG0330	HflC and HflK could
EBA18_RS16000	COG3956	TIGRFAM MazG family protein
EBA18_RS16010	COG0494	nUDIX hydrolase
EBA18_RS16020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EBA18_RS16025	COG0837	glucose binding
EBA18_RS16040	COG1388	LysM domain
EBA18_RS16040	COG3858	chitin binding
EBA18_RS16060	COG1472	Belongs to the glycosyl hydrolase 3 family
EBA18_RS16125	COG3537	Alpha-1,2-mannosidase
EBA18_RS16175	COG1446	asparaginase
EBA18_RS16225	COG0784	Response regulator, receiver
EBA18_RS16225	COG0643	Histidine kinase
EBA18_RS16225	COG2198	Histidine kinase
EBA18_RS16230	COG0840	transmembrane signaling receptor activity
EBA18_RS16250	COG0189	ligase activity
EBA18_RS16260	COG1397	ADP-ribosylglycohydrolase
EBA18_RS16270	COG1199	ATP-dependent helicase activity
EBA18_RS16280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EBA18_RS16285	COG1215	transferase activity, transferring glycosyl groups
EBA18_RS16295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EBA18_RS16310	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EBA18_RS16315	COG0535	radical SAM domain protein
EBA18_RS16320	COG0535	radical SAM domain protein
EBA18_RS16355	COG1643	Atp-dependent helicase
EBA18_RS16360	COG0783	Belongs to the Dps family
EBA18_RS16370	COG0514	ATP-dependent DNA helicase (RecQ)
EBA18_RS16395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EBA18_RS16420	COG0602	queuosine metabolic process
EBA18_RS16430	COG2885	chlorophyll binding
EBA18_RS16435	COG0823	Involved in the tonB-independent uptake of proteins
EBA18_RS16445	COG0848	biopolymer transport protein
EBA18_RS16455	COG0824	Thioesterase
EBA18_RS16460	COG2255	four-way junction helicase activity
EBA18_RS16470	COG0632	four-way junction helicase activity
EBA18_RS16675	COG2022	thiamine diphosphate biosynthetic process
EBA18_RS16690	COG3273	potassium ion transport
EBA18_RS16690	COG0471	metal ion transport
EBA18_RS16720	COG1970	mechanosensitive ion channel activity
EBA18_RS16745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBA18_RS16775	COG0308	aminopeptidase N
EBA18_RS16780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA18_RS16795	COG2895	sulfate adenylyltransferase (ATP) activity
EBA18_RS16795	COG0529	Catalyzes the synthesis of activated sulfate
EBA18_RS16800	COG0175	sulfate reduction
EBA18_RS16805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EBA18_RS16810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EBA18_RS16815	COG0175	sulfate reduction
EBA18_RS16835	COG2205	protein histidine kinase activity
EBA18_RS16835	COG0784	Response regulator, receiver
EBA18_RS16835	COG2198	Histidine kinase
EBA18_RS16880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EBA18_RS16885	COG3588	fructose-bisphosphate aldolase
EBA18_RS16890	COG0469	pyruvate kinase activity
EBA18_RS16900	COG0126	phosphoglycerate kinase activity
EBA18_RS16935	COG0753	catalase activity
EBA18_RS16965	COG2207	Transcriptional regulator
EBA18_RS16965	COG1917	Cupin 2, conserved barrel domain protein
EBA18_RS16985	COG1506	peptidase
EBA18_RS16985	COG0823	Involved in the tonB-independent uptake of proteins
EBA18_RS17010	COG1297	OPT oligopeptide transporter protein
EBA18_RS17030	COG0587	DNA-directed DNA polymerase activity
EBA18_RS17130	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EBA18_RS17135	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EBA18_RS17140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EBA18_RS17160	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EBA18_RS17175	COG0732	type I restriction modification DNA specificity domain
EBA18_RS17355	COG3179	chitinase
EBA18_RS17395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBA18_RS17405	COG0412	Dienelactone hydrolase
EBA18_RS17425	COG0717	Belongs to the dCTP deaminase family
EBA18_RS17430	COG0489	protein tyrosine kinase activity
EBA18_RS17475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA18_RS17480	COG2311	Membrane
EBA18_RS17485	COG1047	Peptidyl-prolyl cis-trans
EBA18_RS17490	COG0791	NLP P60 protein
EBA18_RS17495	COG0791	NLP P60 protein
EBA18_RS17515	COG1301	dicarboxylic acid transport
EBA18_RS17520	COG1785	Belongs to the alkaline phosphatase family
EBA18_RS17525	COG0037	tRNA processing
EBA18_RS17530	COG1722	exodeoxyribonuclease VII activity
EBA18_RS17535	COG0142	geranyltranstransferase activity
EBA18_RS17560	COG0312	modulator of DNA gyrase
EBA18_RS17565	COG3028	Belongs to the UPF0307 family
EBA18_RS17570	COG0312	modulator of DNA gyrase
EBA18_RS17580	COG3164	Protein of unknown function
EBA18_RS17595	COG2968	Membrane
EBA18_RS17625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EBA18_RS17650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EBA18_RS17680	COG3118	belongs to the thioredoxin family
EBA18_RS17745	COG3039	Transposase
EBA18_RS17770	COG3039	Transposase
EBA18_RS17800	COG3209	COG3209 Rhs family protein
EBA18_RS17805	COG3039	Transposase
EBA18_RS17830	COG3209	COG3209 Rhs family protein
EBA18_RS17845	COG3039	Transposase
EBA18_RS17880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EBA18_RS17885	COG1845	cytochrome c oxidase, subunit III
EBA18_RS17890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EBA18_RS17905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EBA18_RS17910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EBA18_RS17920	COG0196	riboflavin kinase activity
EBA18_RS17925	COG0728	peptidoglycan biosynthetic process
EBA18_RS17930	COG0268	Binds directly to 16S ribosomal RNA
EBA18_RS17935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EBA18_RS17940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EBA18_RS17950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EBA18_RS17955	COG0824	Thioesterase
EBA18_RS17970	COG1946	Acyl-CoA thioesterase
EBA18_RS17980	COG1595	DNA-templated transcription, initiation
EBA18_RS17995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EBA18_RS18035	COG1877	trehalose-phosphatase activity
EBA18_RS18040	COG3387	PFAM Glycoside hydrolase 15-related
EBA18_RS18065	COG0564	pseudouridine synthase activity
EBA18_RS18070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA18_RS18075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBA18_RS18075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EBA18_RS18085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EBA18_RS18090	COG0045	succinate-CoA ligase (ADP-forming) activity
EBA18_RS18130	COG2194	sulfuric ester hydrolase activity
EBA18_RS18145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EBA18_RS18180	COG3039	Transposase
EBA18_RS18195	COG3209	COG3209 Rhs family protein
EBA18_RS18205	COG3039	Transposase
EBA18_RS18210	COG3039	Transposase
EBA18_RS18260	COG1132	(ABC) transporter
EBA18_RS18290	COG0745	RESPONSE REGULATOR receiver
EBA18_RS18295	COG5000	phosphorelay sensor kinase activity
EBA18_RS18295	COG5002	protein histidine kinase activity
EBA18_RS18300	COG0475	glutathione-regulated potassium exporter activity
EBA18_RS18310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBA18_RS18335	COG1187	pseudouridine synthase activity
EBA18_RS18340	COG5001	Diguanylate cyclase
EBA18_RS18340	COG5002	protein histidine kinase activity
EBA18_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS18475	COG0415	Belongs to the DNA photolyase family
EBA18_RS18480	COG0305	Participates in initiation and elongation during chromosome replication
EBA18_RS18490	COG0367	asparagine synthase
EBA18_RS18505	COG1960	acyl-CoA dehydrogenase activity
EBA18_RS18520	COG0084	hydrolase, TatD family'
EBA18_RS18525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EBA18_RS18585	COG0735	belongs to the Fur family
EBA18_RS18590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBA18_RS18640	COG3039	Transposase
EBA18_RS18690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EBA18_RS18700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EBA18_RS18715	COG2198	Histidine kinase
EBA18_RS18715	COG0643	Histidine kinase
EBA18_RS18725	COG0840	transmembrane signaling receptor activity
EBA18_RS18730	COG0835	chemotaxis
EBA18_RS18735	COG2202	Pas domain
EBA18_RS18735	COG2200	EAL domain
EBA18_RS18735	COG2199	diguanylate cyclase activity
EBA18_RS18740	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EBA18_RS18755	COG3590	peptidase
EBA18_RS18770	COG0588	phosphoglycerate mutase activity
EBA18_RS18775	COG1515	deoxyribonuclease V activity
EBA18_RS18785	COG1741	Belongs to the pirin family
EBA18_RS18855	COG3039	Transposase
EBA18_RS18990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EBA18_RS19005	COG2197	response regulator
EBA18_RS19010	COG4585	Histidine kinase
EBA18_RS19030	COG2894	cell division
EBA18_RS19035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EBA18_RS19045	COG0642	Histidine kinase
EBA18_RS19050	COG0745	RESPONSE REGULATOR receiver
EBA18_RS19055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EBA18_RS19065	COG2194	sulfuric ester hydrolase activity
EBA18_RS19095	COG3551	Protein conserved in bacteria
EBA18_RS19160	COG0203	ribosomal protein L17
EBA18_RS19170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EBA18_RS19175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EBA18_RS19185	COG0201	protein transport
EBA18_RS19195	COG1841	ribosomal large subunit assembly
EBA18_RS19205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EBA18_RS19225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EBA18_RS19230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EBA18_RS19235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EBA18_RS19240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EBA18_RS19245	COG0255	Belongs to the universal ribosomal protein uL29 family
EBA18_RS19250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EBA18_RS19260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EBA18_RS19275	COG0089	rRNA binding
EBA18_RS19280	COG0088	Forms part of the polypeptide exit tunnel
EBA18_RS19285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EBA18_RS19290	COG0051	transcription antitermination factor activity, RNA binding
EBA18_RS19310	COG0049	tRNA binding
EBA18_RS19315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EBA18_RS19320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EBA18_RS19325	COG0085	RNA polymerase activity
EBA18_RS19330	COG0222	ribosome binding
EBA18_RS19335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EBA18_RS19345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EBA18_RS19355	COG0250	Participates in transcription elongation, termination and antitermination
EBA18_RS19360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EBA18_RS19390	COG0012	GTP binding
EBA18_RS19395	COG0193	aminoacyl-tRNA hydrolase activity
EBA18_RS19405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EBA18_RS19420	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EBA18_RS19430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EBA18_RS19435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EBA18_RS19445	COG0521	Mo-molybdopterin cofactor biosynthetic process
EBA18_RS19465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBA18_RS19470	COG1295	ribonuclease BN
EBA18_RS19500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EBA18_RS19505	COG1404	Belongs to the peptidase S8 family
EBA18_RS19520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EBA18_RS19550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EBA18_RS19575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EBA18_RS19590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EBA18_RS19590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EBA18_RS19630	COG2890	protein-(glutamine-N5) methyltransferase activity
EBA18_RS19640	COG3634	alkyl hydroperoxide reductase activity
EBA18_RS19645	COG0583	DNA-binding transcription factor activity
EBA18_RS19655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBA18_RS19660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EBA18_RS19710	COG2197	response regulator
EBA18_RS19830	COG3386	PFAM SMP-30 Gluconolaconase
EBA18_RS19850	COG1024	Enoyl-CoA hydratase
EBA18_RS19860	COG0318	PFAM AMP-dependent synthetase and ligase
EBA18_RS19865	COG0583	DNA-binding transcription factor activity
EBA18_RS19905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EBA18_RS19910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EBA18_RS19920	COG2096	Adenosyltransferase
EBA18_RS19925	COG0123	including yeast histone deacetylase and acetoin utilization protein
EBA18_RS19940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EBA18_RS19950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EBA18_RS19955	COG2967	ApaG domain
EBA18_RS19960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EBA18_RS19980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EBA18_RS20000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EBA18_RS20025	COG0642	Histidine kinase
EBA18_RS20040	COG4181	ATPase activity
EBA18_RS20050	COG2175	clavaminate synthase activity
EBA18_RS20100	COG0667	Aldo Keto reductase
EBA18_RS20110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EBA18_RS20115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA18_RS20130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EBA18_RS20145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EBA18_RS20185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EBA18_RS20190	COG2226	methyltransferase
EBA18_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS20245	COG3321	synthase
EBA18_RS20245	COG0604	alcohol dehydrogenase
EBA18_RS20260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EBA18_RS20275	COG0494	nUDIX hydrolase
EBA18_RS20285	COG0653	protein targeting
EBA18_RS20290	COG4942	peptidase
EBA18_RS20290	COG1388	LysM domain
EBA18_RS20300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EBA18_RS20315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EBA18_RS20320	COG1181	Belongs to the D-alanine--D-alanine ligase family
EBA18_RS20325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBA18_RS20340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBA18_RS20345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EBA18_RS20360	COG3116	cell division
EBA18_RS20365	COG0275	rRNA processing
EBA18_RS20400	COG0792	nuclease activity
EBA18_RS20405	COG1988	membrane-bound metal-dependent
EBA18_RS20410	COG0277	FAD linked oxidase domain protein
EBA18_RS20415	COG0745	RESPONSE REGULATOR receiver
EBA18_RS20420	COG2205	protein histidine kinase activity
EBA18_RS20430	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EBA18_RS20435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EBA18_RS20460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EBA18_RS20465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EBA18_RS20470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EBA18_RS20490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBA18_RS20490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBA18_RS20510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EBA18_RS20530	COG0488	(ABC) transporter
EBA18_RS20585	COG2205	protein histidine kinase activity
EBA18_RS20620	COG2205	protein histidine kinase activity
EBA18_RS20635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EBA18_RS20680	COG3039	Transposase
EBA18_RS20685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EBA18_RS20795	COG1649	PFAM Uncharacterised BCR, COG1649
EBA18_RS20795	COG0726	polysaccharide deacetylase
EBA18_RS20800	COG1215	transferase activity, transferring glycosyl groups
EBA18_RS20810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EBA18_RS20815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBA18_RS20820	COG1609	Transcriptional regulator
EBA18_RS20830	COG2188	Transcriptional regulator
EBA18_RS20845	COG3250	beta-galactosidase activity
EBA18_RS20895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EBA18_RS20900	COG4191	Histidine kinase
EBA18_RS20905	COG0784	Response regulator, receiver
EBA18_RS20910	COG4251	negative regulation of phosphorylation
EBA18_RS20915	COG2823	Periplasmic or secreted lipoprotein
EBA18_RS20920	COG0673	inositol 2-dehydrogenase activity
EBA18_RS20925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EBA18_RS20960	COG1051	belongs to the nudix hydrolase family
EBA18_RS20960	COG1056	cytidyltransferase-related domain
EBA18_RS20985	COG2921	Belongs to the UPF0250 family
EBA18_RS20995	COG1686	Belongs to the peptidase S11 family
EBA18_RS21000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EBA18_RS21005	COG2951	lytic endotransglycosylase activity
EBA18_RS21040	COG3039	Transposase
EBA18_RS21070	COG0772	Belongs to the SEDS family
EBA18_RS21085	COG1792	Involved in formation and maintenance of cell shape
EBA18_RS21090	COG1077	Cell shape determining protein MreB Mrl
EBA18_RS21095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA18_RS21145	COG2199	diguanylate cyclase activity
EBA18_RS21150	COG0308	aminopeptidase N
EBA18_RS21180	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EBA18_RS21210	COG0436	Aminotransferase
EBA18_RS21225	COG1505	serine-type exopeptidase activity
EBA18_RS21250	COG0181	hydroxymethylbilane synthase activity
EBA18_RS21260	COG3275	phosphorelay sensor kinase activity
EBA18_RS21315	COG0659	secondary active sulfate transmembrane transporter activity
EBA18_RS21320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA18_RS21320	COG5297	Belongs to the glycosyl hydrolase family 6
EBA18_RS21330	COG0840	transmembrane signaling receptor activity
EBA18_RS21390	COG3039	Transposase
EBA18_RS21410	COG0598	Magnesium transport protein CorA
EBA18_RS21420	COG1113	amino acid transport
EBA18_RS21430	COG5297	Belongs to the glycosyl hydrolase family 6
EBA18_RS21435	COG4305	rare lipoprotein A
EBA18_RS21440	COG0697	spore germination
EBA18_RS21505	COG4221	oxidoreductase activity
EBA18_RS21535	COG0456	acetyltransferase
EBA18_RS21545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EBA18_RS21600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EBA18_RS21600	COG2111	Na H antiporter
EBA18_RS21605	COG1006	Multisubunit Na H antiporter MnhC subunit
EBA18_RS21610	COG0651	ATP synthesis coupled electron transport
EBA18_RS21620	COG2212	antiporter activity
EBA18_RS21625	COG1320	monovalent cation:proton antiporter activity
EBA18_RS21635	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EBA18_RS21655	COG3104	oligopeptide transport
EBA18_RS21660	COG3483	tryptophan 2,3-dioxygenase activity
EBA18_RS21670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EBA18_RS21705	COG0183	Belongs to the thiolase family
EBA18_RS21750	COG3039	Transposase
EBA18_RS21825	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EBA18_RS21830	COG3023	N-Acetylmuramoyl-L-alanine amidase
EBA18_RS21840	COG4948	Mandelate Racemase Muconate Lactonizing
EBA18_RS21870	COG0531	amino acid
EBA18_RS21895	COG4682	membrane
EBA18_RS21900	COG2133	pyrroloquinoline quinone binding
EBA18_RS21960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EBA18_RS21965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EBA18_RS21975	COG1610	YqeY-like protein
EBA18_RS21995	COG1295	ribonuclease BN
EBA18_RS22000	COG0358	DNA primase activity
EBA18_RS22045	COG3039	Transposase
EBA18_RS22105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EBA18_RS22115	COG1560	Kdo2-lipid A biosynthetic process
EBA18_RS22165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EBA18_RS22165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EBA18_RS22170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EBA18_RS22175	COG0242	peptide deformylase activity
EBA18_RS22180	COG1652	LysM domain
EBA18_RS22185	COG0758	DNA mediated transformation
EBA18_RS22190	COG2922	Belongs to the Smg family
EBA18_RS22205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EBA18_RS22205	COG1754	DNA topoisomerase type I activity
EBA18_RS22210	COG0009	L-threonylcarbamoyladenylate synthase
EBA18_RS22225	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS22235	COG0616	signal peptide processing
EBA18_RS22240	COG0534	Mate efflux family protein
EBA18_RS22265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EBA18_RS22300	COG1324	tolerance protein
EBA18_RS22320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EBA18_RS22325	COG0511	ligase activity, forming carbon-carbon bonds
EBA18_RS22335	COG0439	Biotin carboxylase
EBA18_RS22395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EBA18_RS22445	COG3210	domain, Protein
EBA18_RS22485	COG3210	domain, Protein
EBA18_RS22490	COG2831	hemolysin activation secretion protein
EBA18_RS22520	COG2267	carboxylic ester hydrolase activity
EBA18_RS22530	COG2267	carboxylic ester hydrolase activity
EBA18_RS22545	COG0419	ATPase involved in DNA repair
EBA18_RS22555	COG0151	Belongs to the GarS family
EBA18_RS22575	COG1289	transmembrane transporter activity
EBA18_RS22590	COG2814	Major facilitator Superfamily
EBA18_RS22615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EBA18_RS22650	COG0745	RESPONSE REGULATOR receiver
EBA18_RS22700	COG0739	heme binding
EBA18_RS22715	COG2211	Major facilitator Superfamily
EBA18_RS22720	COG0708	Exodeoxyribonuclease III
EBA18_RS22735	COG1192	Involved in chromosome partitioning
EBA18_RS22740	COG1475	DNA binding
EBA18_RS22760	COG0463	Glycosyl transferase, family 2
EBA18_RS22785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EBA18_RS22810	COG4221	oxidoreductase activity
EBA18_RS22835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EBA18_RS22840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EBA18_RS22855	COG3485	protocatechuate 3,4-dioxygenase
EBA18_RS22860	COG3485	protocatechuate 3,4-dioxygenase
EBA18_RS22900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EBA18_RS22910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EBA18_RS22925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EBA18_RS22925	COG1042	CoA-binding domain protein
EBA18_RS22925	COG0045	succinate-CoA ligase (ADP-forming) activity
EBA18_RS22935	COG2239	Acts as a magnesium transporter
EBA18_RS22950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EBA18_RS22970	COG3100	YcgL domain-containing protein
EBA18_RS22975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EBA18_RS22985	COG0463	Glycosyl transferase, family 2
EBA18_RS23000	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS23015	COG0156	8-amino-7-oxononanoate synthase activity
EBA18_RS23020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EBA18_RS23025	COG1040	competence protein
EBA18_RS23030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EBA18_RS23045	COG0628	permease
EBA18_RS23055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EBA18_RS23065	COG1595	DNA-templated transcription, initiation
EBA18_RS23070	COG0753	catalase activity
EBA18_RS23125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBA18_RS23130	COG0180	Tryptophanyl-tRNA synthetase
EBA18_RS23135	COG3237	CsbD-like
EBA18_RS23175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EBA18_RS23190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EBA18_RS23195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EBA18_RS23195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EBA18_RS23235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EBA18_RS23265	COG1566	PFAM secretion protein HlyD family protein
EBA18_RS23285	COG1199	ATP-dependent helicase activity
EBA18_RS23320	COG0583	DNA-binding transcription factor activity
EBA18_RS23370	COG0625	glutathione transferase activity
EBA18_RS23405	COG4555	ABC transporter
EBA18_RS23415	COG1476	TRANSCRIPTIONal
EBA18_RS23440	COG1131	(ABC) transporter
EBA18_RS23445	COG0842	Transport permease protein
EBA18_RS23560	COG1181	Belongs to the D-alanine--D-alanine ligase family
EBA18_RS23575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EBA18_RS23585	COG0564	pseudouridine synthase activity
EBA18_RS23615	COG0339	signal peptide processing
EBA18_RS23645	COG3254	rhamnose metabolic process
EBA18_RS23650	COG0738	Major facilitator superfamily
EBA18_RS23655	COG1414	Transcriptional regulator
EBA18_RS23670	COG2205	protein histidine kinase activity
EBA18_RS23680	COG3459	Glycosyltransferase 36 associated
EBA18_RS23685	COG2211	Major facilitator Superfamily
EBA18_RS23690	COG3265	gluconokinase activity
EBA18_RS23700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA18_RS23740	COG3039	Transposase
EBA18_RS23805	COG1127	ABC transporter
EBA18_RS23810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EBA18_RS23815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EBA18_RS23830	COG2853	Lipoprotein
EBA18_RS23860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EBA18_RS23930	COG0676	glucose-6-phosphate 1-epimerase activity
EBA18_RS23950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA18_RS23960	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA18_RS23970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA18_RS23980	COG1064	alcohol dehydrogenase
EBA18_RS24030	COG1522	sequence-specific DNA binding
EBA18_RS24035	COG3186	Phenylalanine-4-hydroxylase
EBA18_RS24050	COG2755	lipolytic protein G-D-S-L family
EBA18_RS24075	COG0656	L-ascorbic acid biosynthetic process
EBA18_RS24080	COG2130	NADP-dependent
EBA18_RS24085	COG0667	Aldo Keto reductase
EBA18_RS24095	COG1187	pseudouridine synthase activity
EBA18_RS24110	COG1643	Atp-dependent helicase
EBA18_RS24115	COG4807	Protein conserved in bacteria
EBA18_RS24120	COG4948	Mandelate Racemase Muconate Lactonizing
EBA18_RS24130	COG0179	Fumarylacetoacetate (FAA) hydrolase
EBA18_RS24135	COG1028	Short-chain dehydrogenase reductase Sdr
EBA18_RS24155	COG3507	Belongs to the glycosyl hydrolase 43 family
EBA18_RS24195	COG3162	membrane
EBA18_RS24200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EBA18_RS24215	COG0708	Exodeoxyribonuclease III
EBA18_RS24230	COG2091	lysine biosynthetic process via aminoadipic acid
EBA18_RS24240	COG3540	Alkaline phosphatase
EBA18_RS24245	COG0357	Ribosomal RNA small subunit methyltransferase G
EBA18_RS24270	COG2159	amidohydrolase
EBA18_RS24285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBA18_RS24290	COG0583	DNA-binding transcription factor activity
EBA18_RS24295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA18_RS24315	COG0210	DNA helicase
EBA18_RS24330	COG0531	amino acid
EBA18_RS24345	COG1322	Protein conserved in bacteria
EBA18_RS24360	COG0386	Belongs to the glutathione peroxidase family
EBA18_RS24425	COG0793	Belongs to the peptidase S41A family
EBA18_RS24430	COG4942	peptidase
EBA18_RS24440	COG2234	aminopeptidase activity
EBA18_RS24485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBA18_RS24490	COG0302	gtp cyclohydrolase
EBA18_RS24510	COG0477	Major facilitator Superfamily
EBA18_RS24520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA18_RS24595	COG1192	Involved in chromosome partitioning
EBA18_RS24625	COG1929	Belongs to the glycerate kinase type-1 family
EBA18_RS24630	COG2271	Major facilitator Superfamily
EBA18_RS24645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBA18_RS24655	COG0861	Integral membrane protein TerC family
EBA18_RS24665	COG0584	glycerophosphoryl diester phosphodiesterase
EBA18_RS24675	COG0671	phosphoesterase, PA-phosphatase related
EBA18_RS24680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EBA18_RS24690	COG0726	polysaccharide deacetylase
EBA18_RS24695	COG0706	membrane insertase activity
EBA18_RS24840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EBA18_RS24840	COG0551	DNA topoisomerase type I activity
EBA18_RS24860	COG0358	DNA primase activity
EBA18_RS24925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB