locus-tag	class	description
EYR03_RS00025	COG0187	DNA topoisomerase II activity
EYR03_RS00035	COG0501	Belongs to the peptidase M48B family
EYR03_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EYR03_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EYR03_RS00095	COG3039	Transposase
EYR03_RS00145	COG0793	Belongs to the peptidase S41A family
EYR03_RS00150	COG4942	peptidase
EYR03_RS00160	COG2234	aminopeptidase activity
EYR03_RS00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EYR03_RS00185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EYR03_RS00195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EYR03_RS00205	COG1064	alcohol dehydrogenase
EYR03_RS00235	COG0493	'glutamate synthase
EYR03_RS00240	COG0067	glutamate synthase
EYR03_RS00240	COG0069	glutamate synthase activity
EYR03_RS00240	COG0070	glutamate synthase
EYR03_RS00310	COG1205	dead DEAH box helicase
EYR03_RS00310	COG1111	helicase
EYR03_RS00315	COG1272	protein, Hemolysin III
EYR03_RS00345	COG2032	superoxide dismutase activity
EYR03_RS00350	COG2204	response regulator
EYR03_RS00355	COG3852	Histidine kinase
EYR03_RS00360	COG0004	ammonium transporteR
EYR03_RS00365	COG0347	Belongs to the P(II) protein family
EYR03_RS00370	COG0174	glutamine synthetase
EYR03_RS00375	COG1968	undecaprenyl-diphosphatase activity
EYR03_RS00425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EYR03_RS00435	COG2062	phosphohistidine phosphatase, SixA
EYR03_RS00440	COG0489	protein tyrosine kinase activity
EYR03_RS00460	COG1396	sequence-specific DNA binding
EYR03_RS00465	COG3550	peptidyl-serine autophosphorylation
EYR03_RS00470	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EYR03_RS00475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYR03_RS00490	COG1125	glycine betaine transport
EYR03_RS00505	COG1119	ATPase activity
EYR03_RS00520	COG1752	Esterase of the alpha-beta hydrolase superfamily
EYR03_RS00530	COG1522	sequence-specific DNA binding
EYR03_RS00535	COG3186	Phenylalanine-4-hydroxylase
EYR03_RS00565	COG1609	Transcriptional regulator
EYR03_RS00605	COG0366	Alpha amylase catalytic
EYR03_RS00610	COG0366	Alpha amylase catalytic
EYR03_RS00620	COG3039	Transposase
EYR03_RS00670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EYR03_RS00675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EYR03_RS00690	COG0028	Belongs to the TPP enzyme family
EYR03_RS00695	COG4191	Histidine kinase
EYR03_RS00720	COG3039	Transposase
EYR03_RS00730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EYR03_RS00745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EYR03_RS00750	COG3177	Filamentation induced by cAMP protein fic
EYR03_RS00755	COG0596	Alpha beta hydrolase
EYR03_RS00765	COG0727	PFAM Uncharacterised protein family (UPF0153)
EYR03_RS00770	COG0318	PFAM AMP-dependent synthetase and ligase
EYR03_RS00775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYR03_RS00790	COG1181	Belongs to the D-alanine--D-alanine ligase family
EYR03_RS00805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EYR03_RS00820	COG0564	pseudouridine synthase activity
EYR03_RS00850	COG0339	signal peptide processing
EYR03_RS00895	COG4770	biotin carboxylase activity
EYR03_RS00900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EYR03_RS00905	COG1960	acyl-CoA dehydrogenase activity
EYR03_RS00960	COG0697	spore germination
EYR03_RS00970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EYR03_RS00975	COG1846	Transcriptional regulator
EYR03_RS00980	COG1764	response to oxidative stress
EYR03_RS01030	COG0656	L-ascorbic acid biosynthetic process
EYR03_RS01045	COG2130	NADP-dependent
EYR03_RS01060	COG1187	pseudouridine synthase activity
EYR03_RS01075	COG1643	Atp-dependent helicase
EYR03_RS01085	COG4807	Protein conserved in bacteria
EYR03_RS01090	COG2072	flavoprotein involved in K transport
EYR03_RS01110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EYR03_RS01115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYR03_RS01155	COG3039	Transposase
EYR03_RS01200	COG0084	hydrolase, TatD family'
EYR03_RS01220	COG0583	DNA-binding transcription factor activity
EYR03_RS01225	COG2814	Major facilitator Superfamily
EYR03_RS01235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EYR03_RS01240	COG1902	pentaerythritol trinitrate reductase activity
EYR03_RS01270	COG0745	RESPONSE REGULATOR receiver
EYR03_RS01290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EYR03_RS01295	COG0583	DNA-binding transcription factor activity
EYR03_RS01325	COG0702	epimerase
EYR03_RS01330	COG1733	regulation of RNA biosynthetic process
EYR03_RS01365	COG3039	Transposase
EYR03_RS01400	COG0129	dihydroxy-acid dehydratase activity
EYR03_RS01410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EYR03_RS01480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EYR03_RS01485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EYR03_RS01495	COG3485	protocatechuate 3,4-dioxygenase
EYR03_RS01500	COG3485	protocatechuate 3,4-dioxygenase
EYR03_RS01515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EYR03_RS01520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EYR03_RS01535	COG1414	Transcriptional regulator
EYR03_RS01575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EYR03_RS01615	COG0156	8-amino-7-oxononanoate synthase activity
EYR03_RS01620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EYR03_RS01625	COG1040	competence protein
EYR03_RS01630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EYR03_RS01735	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EYR03_RS01810	COG3264	Mechanosensitive ion channel
EYR03_RS01810	COG1511	domain protein
EYR03_RS01820	COG3039	Transposase
EYR03_RS01825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EYR03_RS01835	COG2354	Protein conserved in bacteria
EYR03_RS01860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EYR03_RS01885	COG0702	epimerase
EYR03_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS01940	COG0513	Belongs to the DEAD box helicase family
EYR03_RS01950	COG3039	Transposase
EYR03_RS01980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EYR03_RS01990	COG3483	tryptophan 2,3-dioxygenase activity
EYR03_RS01995	COG3104	oligopeptide transport
EYR03_RS02015	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EYR03_RS02025	COG1320	monovalent cation:proton antiporter activity
EYR03_RS02030	COG2212	antiporter activity
EYR03_RS02040	COG0651	ATP synthesis coupled electron transport
EYR03_RS02045	COG1006	Multisubunit Na H antiporter MnhC subunit
EYR03_RS02050	COG2111	Na H antiporter
EYR03_RS02050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EYR03_RS02085	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EYR03_RS02095	COG0456	acetyltransferase
EYR03_RS02135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EYR03_RS02140	COG0134	indole-3-glycerol-phosphate synthase activity
EYR03_RS02150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EYR03_RS02155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EYR03_RS02165	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EYR03_RS02170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EYR03_RS02175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EYR03_RS02245	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EYR03_RS02265	COG2814	Major facilitator Superfamily
EYR03_RS02275	COG2814	Major facilitator Superfamily
EYR03_RS02280	COG1289	transmembrane transporter activity
EYR03_RS02290	COG0151	Belongs to the GarS family
EYR03_RS02300	COG0138	bifunctional purine biosynthesis protein purh
EYR03_RS02305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EYR03_RS02315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EYR03_RS02370	COG0439	Biotin carboxylase
EYR03_RS02380	COG0511	ligase activity, forming carbon-carbon bonds
EYR03_RS02385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EYR03_RS02400	COG1324	tolerance protein
EYR03_RS02420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EYR03_RS02440	COG0534	Mate efflux family protein
EYR03_RS02445	COG0616	signal peptide processing
EYR03_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS02470	COG0009	L-threonylcarbamoyladenylate synthase
EYR03_RS02475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EYR03_RS02475	COG1754	DNA topoisomerase type I activity
EYR03_RS02495	COG0758	DNA mediated transformation
EYR03_RS02500	COG1652	LysM domain
EYR03_RS02505	COG0242	peptide deformylase activity
EYR03_RS02515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EYR03_RS02515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EYR03_RS02565	COG1560	Kdo2-lipid A biosynthetic process
EYR03_RS02575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EYR03_RS02605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EYR03_RS02610	COG3118	belongs to the thioredoxin family
EYR03_RS02620	COG2884	Cell division ATP-binding protein ftsE
EYR03_RS02625	COG2177	Part of the ABC transporter FtsEX involved in
EYR03_RS02630	COG3437	response regulator, receiver
EYR03_RS02635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EYR03_RS02640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EYR03_RS02645	COG2860	membrane
EYR03_RS02650	COG1252	NADH dehydrogenase
EYR03_RS02675	COG0459	protein refolding
EYR03_RS02690	COG3039	Transposase
EYR03_RS02700	COG3039	Transposase
EYR03_RS02710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EYR03_RS02725	COG3386	PFAM SMP-30 Gluconolaconase
EYR03_RS02740	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EYR03_RS02785	COG2353	YceI-like domain
EYR03_RS02895	COG4221	oxidoreductase activity
EYR03_RS02955	COG0697	spore germination
EYR03_RS02960	COG4305	rare lipoprotein A
EYR03_RS02965	COG5297	Belongs to the glycosyl hydrolase family 6
EYR03_RS02975	COG1113	amino acid transport
EYR03_RS02985	COG0598	Magnesium transport protein CorA
EYR03_RS03070	COG3300	MHYT domain
EYR03_RS03070	COG5001	Diguanylate cyclase
EYR03_RS03095	COG5297	Belongs to the glycosyl hydrolase family 6
EYR03_RS03095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EYR03_RS03100	COG0659	secondary active sulfate transmembrane transporter activity
EYR03_RS03125	COG2943	transferase activity, transferring hexosyl groups
EYR03_RS03135	COG3275	phosphorelay sensor kinase activity
EYR03_RS03145	COG0181	hydroxymethylbilane synthase activity
EYR03_RS03170	COG1505	serine-type exopeptidase activity
EYR03_RS03180	COG0436	Aminotransferase
EYR03_RS03190	COG2832	Protein of unknown function (DUF454)
EYR03_RS03210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EYR03_RS03220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EYR03_RS03255	COG5001	Diguanylate cyclase
EYR03_RS03255	COG3300	MHYT domain
EYR03_RS03260	COG0308	aminopeptidase N
EYR03_RS03275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYR03_RS03280	COG1077	Cell shape determining protein MreB Mrl
EYR03_RS03285	COG1792	Involved in formation and maintenance of cell shape
EYR03_RS03300	COG0772	Belongs to the SEDS family
EYR03_RS03325	COG2951	lytic endotransglycosylase activity
EYR03_RS03330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EYR03_RS03335	COG1686	Belongs to the peptidase S11 family
EYR03_RS03350	COG2921	Belongs to the UPF0250 family
EYR03_RS03375	COG1056	cytidyltransferase-related domain
EYR03_RS03375	COG1051	belongs to the nudix hydrolase family
EYR03_RS03410	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EYR03_RS03415	COG0673	inositol 2-dehydrogenase activity
EYR03_RS03420	COG2823	Periplasmic or secreted lipoprotein
EYR03_RS03425	COG4251	negative regulation of phosphorylation
EYR03_RS03430	COG0784	Response regulator, receiver
EYR03_RS03435	COG4191	Histidine kinase
EYR03_RS03440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EYR03_RS03465	COG3039	Transposase
EYR03_RS03485	COG3250	beta-galactosidase activity
EYR03_RS03500	COG2188	Transcriptional regulator
EYR03_RS03510	COG1609	Transcriptional regulator
EYR03_RS03515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EYR03_RS03520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EYR03_RS03535	COG1215	transferase activity, transferring glycosyl groups
EYR03_RS03540	COG0726	polysaccharide deacetylase
EYR03_RS03540	COG1649	PFAM Uncharacterised BCR, COG1649
EYR03_RS03560	COG3039	Transposase
EYR03_RS03605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EYR03_RS03645	COG2205	protein histidine kinase activity
EYR03_RS03675	COG3791	Glutathione-dependent formaldehyde-activating
EYR03_RS03690	COG3039	Transposase
EYR03_RS03705	COG0488	(ABC) transporter
EYR03_RS03725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EYR03_RS03735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EYR03_RS03745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EYR03_RS03745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EYR03_RS03770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EYR03_RS03775	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EYR03_RS03800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EYR03_RS03805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EYR03_RS03815	COG2205	protein histidine kinase activity
EYR03_RS03820	COG0745	RESPONSE REGULATOR receiver
EYR03_RS03850	COG0277	FAD linked oxidase domain protein
EYR03_RS03860	COG0792	nuclease activity
EYR03_RS03900	COG0275	rRNA processing
EYR03_RS03905	COG3116	cell division
EYR03_RS03920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EYR03_RS03925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EYR03_RS03940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EYR03_RS03945	COG1181	Belongs to the D-alanine--D-alanine ligase family
EYR03_RS03950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EYR03_RS03965	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EYR03_RS03975	COG0741	lytic transglycosylase activity
EYR03_RS03975	COG0739	heme binding
EYR03_RS03975	COG1196	nuclear chromosome segregation
EYR03_RS03990	COG0494	nUDIX hydrolase
EYR03_RS04005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EYR03_RS04020	COG0604	alcohol dehydrogenase
EYR03_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS04020	COG3321	synthase
EYR03_RS04080	COG2226	methyltransferase
EYR03_RS04085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EYR03_RS04110	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS04135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EYR03_RS04150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EYR03_RS04160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYR03_RS04165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EYR03_RS04175	COG0667	Aldo Keto reductase
EYR03_RS04200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EYR03_RS04210	COG2175	clavaminate synthase activity
EYR03_RS04220	COG4181	ATPase activity
EYR03_RS04235	COG0642	Histidine kinase
EYR03_RS04250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EYR03_RS04270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EYR03_RS04290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EYR03_RS04295	COG2967	ApaG domain
EYR03_RS04300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EYR03_RS04315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EYR03_RS04330	COG0123	including yeast histone deacetylase and acetoin utilization protein
EYR03_RS04335	COG2096	Adenosyltransferase
EYR03_RS04350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EYR03_RS04355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EYR03_RS04375	COG1802	Transcriptional regulator
EYR03_RS04385	COG3384	dioxygenase
EYR03_RS04390	COG0583	DNA-binding transcription factor activity
EYR03_RS04395	COG0318	PFAM AMP-dependent synthetase and ligase
EYR03_RS04405	COG1024	Enoyl-CoA hydratase
EYR03_RS04425	COG3386	PFAM SMP-30 Gluconolaconase
EYR03_RS04475	COG2197	response regulator
EYR03_RS04485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EYR03_RS04495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EYR03_RS04505	COG0583	DNA-binding transcription factor activity
EYR03_RS04510	COG3634	alkyl hydroperoxide reductase activity
EYR03_RS04520	COG2890	protein-(glutamine-N5) methyltransferase activity
EYR03_RS04555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EYR03_RS04555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EYR03_RS04570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EYR03_RS04625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EYR03_RS04635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EYR03_RS04665	COG1295	ribonuclease BN
EYR03_RS04670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EYR03_RS04675	COG1254	Belongs to the acylphosphatase family
EYR03_RS04690	COG0521	Mo-molybdopterin cofactor biosynthetic process
EYR03_RS04700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EYR03_RS04705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EYR03_RS04715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EYR03_RS04730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EYR03_RS04740	COG0193	aminoacyl-tRNA hydrolase activity
EYR03_RS04745	COG0012	GTP binding
EYR03_RS04780	COG0250	Participates in transcription elongation, termination and antitermination
EYR03_RS04790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EYR03_RS04795	COG0081	regulation of translation
EYR03_RS04800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EYR03_RS04810	COG0085	RNA polymerase activity
EYR03_RS04815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EYR03_RS04820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EYR03_RS04825	COG0049	tRNA binding
EYR03_RS04855	COG0088	Forms part of the polypeptide exit tunnel
EYR03_RS04860	COG0089	rRNA binding
EYR03_RS04865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EYR03_RS04875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EYR03_RS04885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EYR03_RS04890	COG0255	Belongs to the universal ribosomal protein uL29 family
EYR03_RS04895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EYR03_RS04900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EYR03_RS04905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EYR03_RS04940	COG1841	ribosomal large subunit assembly
EYR03_RS04945	COG0200	Binds to the 23S rRNA
EYR03_RS04950	COG0201	protein transport
EYR03_RS04960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EYR03_RS04965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EYR03_RS04975	COG0203	ribosomal protein L17
EYR03_RS04995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EYR03_RS05015	COG1217	gtp-binding protein TYPA
EYR03_RS05020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EYR03_RS05030	COG0625	glutathione transferase activity
EYR03_RS05060	COG3039	Transposase
EYR03_RS05080	COG0446	pyridine nucleotide-disulphide oxidoreductase
EYR03_RS05080	COG1902	pentaerythritol trinitrate reductase activity
EYR03_RS05085	COG0604	alcohol dehydrogenase
EYR03_RS05115	COG0156	8-amino-7-oxononanoate synthase activity
EYR03_RS05120	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EYR03_RS05125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EYR03_RS05130	COG4208	sulfate ABC transporter
EYR03_RS05135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EYR03_RS05170	COG0406	alpha-ribazole phosphatase activity
EYR03_RS05180	COG0285	dihydrofolate synthase activity
EYR03_RS05200	COG2833	Protein of unknown function (DUF455)
EYR03_RS05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYR03_RS05230	COG0671	phosphoesterase, PA-phosphatase related
EYR03_RS05235	COG0438	transferase activity, transferring glycosyl groups
EYR03_RS05245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EYR03_RS05250	COG5002	protein histidine kinase activity
EYR03_RS05260	COG4783	chaperone-mediated protein folding
EYR03_RS05275	COG0473	3-isopropylmalate dehydrogenase activity
EYR03_RS05315	COG3039	Transposase
EYR03_RS05340	COG0544	peptidyl-prolyl cis-trans isomerase activity
EYR03_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EYR03_RS05405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EYR03_RS05420	COG0631	protein serine/threonine phosphatase activity
EYR03_RS05455	COG0859	PFAM glycosyl transferase family 9
EYR03_RS05460	COG3642	lipopolysaccharide core region biosynthetic process
EYR03_RS05465	COG1234	tRNA 3'-trailer cleavage
EYR03_RS05470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EYR03_RS05480	COG0315	cyclic pyranopterin monophosphate synthase activity
EYR03_RS05485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EYR03_RS05490	COG0314	molybdopterin synthase activity
EYR03_RS05530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EYR03_RS05540	COG0537	adenosine 5'-monophosphoramidase activity
EYR03_RS05560	COG0714	Associated with various cellular activities
EYR03_RS05580	COG1399	metal-binding, possibly nucleic acid-binding protein
EYR03_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS05610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EYR03_RS05620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EYR03_RS05625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EYR03_RS05660	COG3829	transcription factor binding
EYR03_RS05695	COG3039	Transposase
EYR03_RS05775	COG0330	HflC and HflK could
EYR03_RS05780	COG0330	HflC and HflK could
EYR03_RS05790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EYR03_RS05795	COG0308	aminopeptidase N
EYR03_RS05810	COG0732	type I restriction modification DNA specificity domain
EYR03_RS05825	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EYR03_RS05910	COG0587	DNA-directed DNA polymerase activity
EYR03_RS05930	COG1297	OPT oligopeptide transporter protein
EYR03_RS05950	COG1506	peptidase
EYR03_RS05950	COG0823	Involved in the tonB-independent uptake of proteins
EYR03_RS05960	COG2207	Transcriptional regulator
EYR03_RS05960	COG1917	Cupin 2, conserved barrel domain protein
EYR03_RS06005	COG0753	catalase activity
EYR03_RS06045	COG3551	Protein conserved in bacteria
EYR03_RS06075	COG2194	sulfuric ester hydrolase activity
EYR03_RS06085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EYR03_RS06090	COG0745	RESPONSE REGULATOR receiver
EYR03_RS06095	COG0642	Histidine kinase
EYR03_RS06105	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EYR03_RS06110	COG2894	cell division
EYR03_RS06125	COG4585	Histidine kinase
EYR03_RS06130	COG2197	response regulator
EYR03_RS06170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EYR03_RS06245	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS06270	COG3039	Transposase
EYR03_RS06295	COG3179	chitinase
EYR03_RS06450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EYR03_RS06465	COG1842	Phage shock protein A
EYR03_RS06490	COG0754	glutathionylspermidine amidase activity
EYR03_RS06570	COG0531	amino acid
EYR03_RS06575	COG2197	response regulator
EYR03_RS06580	COG2267	carboxylic ester hydrolase activity
EYR03_RS06590	COG1113	amino acid transport
EYR03_RS06620	COG3039	Transposase
EYR03_RS06630	COG1294	oxidase, subunit
EYR03_RS06640	COG2239	Acts as a magnesium transporter
EYR03_RS06650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EYR03_RS06655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EYR03_RS06670	COG3039	Transposase
EYR03_RS06685	COG1660	Displays ATPase and GTPase activities
EYR03_RS06695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EYR03_RS06710	COG1137	ATPase activity
EYR03_RS06715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EYR03_RS06725	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EYR03_RS06735	COG0271	Belongs to the BolA IbaG family
EYR03_RS06740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EYR03_RS06765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EYR03_RS06780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EYR03_RS06790	COG0628	permease
EYR03_RS06800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EYR03_RS06805	COG3178	'Phosphotransferase
EYR03_RS06815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYR03_RS06820	COG1555	photosystem II stabilization
EYR03_RS06840	COG3039	Transposase
EYR03_RS06850	COG2146	nitrite reductase [NAD(P)H] activity
EYR03_RS06860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EYR03_RS06865	COG0719	Fe-S assembly protein
EYR03_RS06870	COG0396	ATPase activity
EYR03_RS06875	COG0719	Fe-S assembly protein
EYR03_RS06880	COG1959	2 iron, 2 sulfur cluster binding
EYR03_RS06935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EYR03_RS06970	COG0519	Catalyzes the synthesis of GMP from XMP
EYR03_RS06985	COG1678	Uncharacterized ACR, COG1678
EYR03_RS06990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EYR03_RS07005	COG1764	response to oxidative stress
EYR03_RS07015	COG0384	phenazine biosynthesis protein PhzF
EYR03_RS07025	COG0527	aspartate kinase activity
EYR03_RS07055	COG3039	Transposase
EYR03_RS07065	COG0142	geranyltranstransferase activity
EYR03_RS07070	COG0629	single-stranded DNA binding
EYR03_RS07075	COG2203	Gaf domain
EYR03_RS07075	COG5001	Diguanylate cyclase
EYR03_RS07075	COG4251	negative regulation of phosphorylation
EYR03_RS07075	COG3706	GGDEF domain
EYR03_RS07120	COG2879	small protein
EYR03_RS07125	COG1966	Carbon starvation protein
EYR03_RS07130	COG1741	Belongs to the pirin family
EYR03_RS07225	COG1515	deoxyribonuclease V activity
EYR03_RS07245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EYR03_RS07250	COG2202	Pas domain
EYR03_RS07250	COG2200	EAL domain
EYR03_RS07250	COG2199	diguanylate cyclase activity
EYR03_RS07255	COG0835	chemotaxis
EYR03_RS07260	COG0840	transmembrane signaling receptor activity
EYR03_RS07270	COG2198	Histidine kinase
EYR03_RS07270	COG0643	Histidine kinase
EYR03_RS07285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EYR03_RS07295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EYR03_RS07330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EYR03_RS07335	COG0735	belongs to the Fur family
EYR03_RS07365	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS07455	COG3039	Transposase
EYR03_RS07515	COG5001	Diguanylate cyclase
EYR03_RS07515	COG5002	protein histidine kinase activity
EYR03_RS07520	COG1187	pseudouridine synthase activity
EYR03_RS07540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EYR03_RS07550	COG0475	glutathione-regulated potassium exporter activity
EYR03_RS07555	COG5002	protein histidine kinase activity
EYR03_RS07555	COG5000	phosphorelay sensor kinase activity
EYR03_RS07560	COG0745	RESPONSE REGULATOR receiver
EYR03_RS07565	COG1538	Outer membrane efflux protein
EYR03_RS07590	COG1132	(ABC) transporter
EYR03_RS07615	COG3039	Transposase
EYR03_RS07660	COG3118	belongs to the thioredoxin family
EYR03_RS07690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EYR03_RS07710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EYR03_RS07735	COG2968	Membrane
EYR03_RS07750	COG3164	Protein of unknown function
EYR03_RS07760	COG0312	modulator of DNA gyrase
EYR03_RS07765	COG3028	Belongs to the UPF0307 family
EYR03_RS07770	COG0312	modulator of DNA gyrase
EYR03_RS07785	COG4104	PAAR repeat-containing protein
EYR03_RS07795	COG0142	geranyltranstransferase activity
EYR03_RS07800	COG1722	exodeoxyribonuclease VII activity
EYR03_RS07805	COG0037	tRNA processing
EYR03_RS07810	COG1785	Belongs to the alkaline phosphatase family
EYR03_RS07815	COG1301	dicarboxylic acid transport
EYR03_RS07820	COG4106	trans-aconitate 2-methyltransferase activity
EYR03_RS07835	COG0791	NLP P60 protein
EYR03_RS07840	COG0791	NLP P60 protein
EYR03_RS07845	COG1047	Peptidyl-prolyl cis-trans
EYR03_RS07850	COG2311	Membrane
EYR03_RS07855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYR03_RS07885	COG3039	Transposase
EYR03_RS07895	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS07920	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS07925	COG3039	Transposase
EYR03_RS07940	COG0489	protein tyrosine kinase activity
EYR03_RS07950	COG0717	Belongs to the dCTP deaminase family
EYR03_RS07965	COG3039	Transposase
EYR03_RS07985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EYR03_RS07995	COG3039	Transposase
EYR03_RS08005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EYR03_RS08020	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS08030	COG0433	COG0433 Predicted ATPase
EYR03_RS08060	COG2890	protein-(glutamine-N5) methyltransferase activity
EYR03_RS08065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EYR03_RS08070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EYR03_RS08075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EYR03_RS08095	COG0101	tRNA pseudouridine synthase activity
EYR03_RS08100	COG0135	phosphoribosylanthranilate isomerase activity
EYR03_RS08110	COG0133	tryptophan synthase activity
EYR03_RS08130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EYR03_RS08135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EYR03_RS08190	COG0149	triose-phosphate isomerase activity
EYR03_RS08205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYR03_RS08215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYR03_RS08220	COG0649	NAD binding
EYR03_RS08225	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EYR03_RS08230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EYR03_RS08235	COG1034	ATP synthesis coupled electron transport
EYR03_RS08240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EYR03_RS08245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYR03_RS08270	COG1007	ATP synthesis coupled electron transport
EYR03_RS08280	COG0779	Required for maturation of 30S ribosomal subunits
EYR03_RS08285	COG0195	Participates in both transcription termination and antitermination
EYR03_RS08290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EYR03_RS08305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EYR03_RS08310	COG1185	polyribonucleotide nucleotidyltransferase activity
EYR03_RS08345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EYR03_RS08355	COG2095	MarC family integral membrane protein
EYR03_RS08370	COG3039	Transposase
EYR03_RS08375	COG1611	Belongs to the LOG family
EYR03_RS08415	COG4969	Belongs to the N-Me-Phe pilin family
EYR03_RS08420	COG0556	nucleotide-excision repair
EYR03_RS08450	COG3723	Recombinational DNA repair protein, rece pathway
EYR03_RS08550	COG0270	DNA (cytosine-5-)-methyltransferase activity
EYR03_RS08765	COG3723	Recombinational DNA repair protein, rece pathway
EYR03_RS09050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EYR03_RS09060	COG2986	histidine ammonia-lyase
EYR03_RS09065	COG1228	amidohydrolase
EYR03_RS09110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EYR03_RS09115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EYR03_RS09120	COG1605	Chorismate mutase
EYR03_RS09120	COG0077	Prephenate dehydratase
EYR03_RS09125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EYR03_RS09150	COG3039	Transposase
EYR03_RS09160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EYR03_RS09175	COG0583	DNA-binding transcription factor activity
EYR03_RS09190	COG2336	PFAM SpoVT AbrB
EYR03_RS09230	COG0840	transmembrane signaling receptor activity
EYR03_RS09255	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EYR03_RS09260	COG4191	Histidine kinase
EYR03_RS09260	COG0784	Response regulator, receiver
EYR03_RS09275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EYR03_RS09295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EYR03_RS09310	COG1595	DNA-templated transcription, initiation
EYR03_RS09360	COG2244	polysaccharide biosynthetic process
EYR03_RS09390	COG2264	protein methyltransferase activity
EYR03_RS09400	COG0438	transferase activity, transferring glycosyl groups
EYR03_RS09415	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EYR03_RS09420	COG1132	(ABC) transporter
EYR03_RS09430	COG0477	Major facilitator Superfamily
EYR03_RS09450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EYR03_RS09465	COG1253	flavin adenine dinucleotide binding
EYR03_RS09480	COG0306	phosphate transporter
EYR03_RS09510	COG0504	CTP synthase activity
EYR03_RS09515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EYR03_RS09520	COG0148	phosphopyruvate hydratase activity
EYR03_RS09525	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EYR03_RS09540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EYR03_RS09550	COG2840	Smr protein MutS2
EYR03_RS09555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EYR03_RS09560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EYR03_RS09565	COG1238	metal cluster binding
EYR03_RS09580	COG1534	Rna-binding protein
EYR03_RS09585	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EYR03_RS09595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EYR03_RS09610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EYR03_RS09615	COG1546	Belongs to the CinA family
EYR03_RS09630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EYR03_RS09640	COG2137	regulation of response to DNA damage stimulus
EYR03_RS09645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EYR03_RS09650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EYR03_RS09700	COG1741	Belongs to the pirin family
EYR03_RS09705	COG0583	DNA-binding transcription factor activity
EYR03_RS09730	COG0351	phosphomethylpyrimidine kinase
EYR03_RS09730	COG0352	thiamine-phosphate diphosphorylase activity
EYR03_RS09740	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EYR03_RS09745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EYR03_RS09760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYR03_RS09770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EYR03_RS09775	COG3734	2-keto-3-deoxy-galactonokinase
EYR03_RS09785	COG4948	Mandelate Racemase Muconate Lactonizing
EYR03_RS09790	COG0800	Aldolase
EYR03_RS09815	COG1070	Carbohydrate kinase
EYR03_RS09845	COG0860	N-Acetylmuramoyl-L-alanine amidase
EYR03_RS09850	COG1469	GTP cyclohydrolase I activity
EYR03_RS09860	COG0617	tRNA 3'-terminal CCA addition
EYR03_RS09880	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EYR03_RS09910	COG1472	Belongs to the glycosyl hydrolase 3 family
EYR03_RS09930	COG2203	Gaf domain
EYR03_RS09930	COG5001	Diguanylate cyclase
EYR03_RS09930	COG4251	negative regulation of phosphorylation
EYR03_RS09930	COG3706	GGDEF domain
EYR03_RS09940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EYR03_RS09950	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EYR03_RS09965	COG0671	phosphoesterase, PA-phosphatase related
EYR03_RS09985	COG1794	racemase activity, acting on amino acids and derivatives
EYR03_RS09995	COG0697	spore germination
EYR03_RS10000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EYR03_RS10025	COG1012	belongs to the aldehyde dehydrogenase family
EYR03_RS10090	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EYR03_RS10105	COG0124	histidyl-tRNA synthetase
EYR03_RS10125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EYR03_RS10140	COG0131	Imidazoleglycerol-phosphate dehydratase
EYR03_RS10140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EYR03_RS10150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EYR03_RS10160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EYR03_RS10160	COG0140	phosphoribosyl-ATP diphosphatase activity
EYR03_RS10180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EYR03_RS10185	COG0235	Class ii aldolase
EYR03_RS10190	COG0531	amino acid
EYR03_RS10195	COG0531	amino acid
EYR03_RS10205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EYR03_RS10210	COG0277	FAD linked oxidase domain protein
EYR03_RS10235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EYR03_RS10290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EYR03_RS10295	COG2258	MOSC domain
EYR03_RS10300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EYR03_RS10305	COG0505	Belongs to the CarA family
EYR03_RS10315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EYR03_RS10320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EYR03_RS10330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EYR03_RS10345	COG3279	Response regulator of the LytR AlgR family
EYR03_RS10370	COG2198	Histidine kinase
EYR03_RS10370	COG2205	protein histidine kinase activity
EYR03_RS10370	COG0784	Response regulator, receiver
EYR03_RS10375	COG1024	Enoyl-CoA hydratase
EYR03_RS10380	COG0318	PFAM AMP-dependent synthetase and ligase
EYR03_RS10410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EYR03_RS10440	COG0840	transmembrane signaling receptor activity
EYR03_RS10450	COG0835	chemotaxis
EYR03_RS10465	COG0840	transmembrane signaling receptor activity
EYR03_RS10470	COG0840	transmembrane signaling receptor activity
EYR03_RS10475	COG0840	transmembrane signaling receptor activity
EYR03_RS10490	COG0840	transmembrane signaling receptor activity
EYR03_RS10500	COG0840	transmembrane signaling receptor activity
EYR03_RS10505	COG0840	transmembrane signaling receptor activity
EYR03_RS10535	COG0840	transmembrane signaling receptor activity
EYR03_RS10540	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS10560	COG0745	RESPONSE REGULATOR receiver
EYR03_RS10570	COG0835	chemotaxis
EYR03_RS10575	COG1192	Involved in chromosome partitioning
EYR03_RS10580	COG1360	Flagellar Motor Protein
EYR03_RS10585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EYR03_RS10610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EYR03_RS10650	COG3039	Transposase
EYR03_RS10715	COG0643	Histidine kinase
EYR03_RS10715	COG2198	Histidine kinase
EYR03_RS10715	COG0784	Response regulator, receiver
EYR03_RS10770	COG1684	flagellar biosynthetic protein fliR
EYR03_RS10785	COG3190	flagellar
EYR03_RS10835	COG1677	Flagellar hook-basal body complex protein FliE
EYR03_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS10880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EYR03_RS10900	COG2201	protein-glutamate methylesterase activity
EYR03_RS10930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EYR03_RS10935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EYR03_RS10950	COG1705	Flagellar rod assembly protein muramidase FlgJ
EYR03_RS10950	COG3951	Flagellar rod assembly protein muramidase FlgJ
EYR03_RS10955	COG1706	bacterial-type flagellum-dependent cell motility
EYR03_RS10960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EYR03_RS10975	COG4787	bacterial-type flagellum-dependent cell motility
EYR03_RS10985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EYR03_RS10990	COG1558	bacterial-type flagellum-dependent cell motility
EYR03_RS11000	COG0784	Response regulator, receiver
EYR03_RS11000	COG0835	chemotaxis
EYR03_RS11020	COG5002	protein histidine kinase activity
EYR03_RS11030	COG4585	Histidine kinase
EYR03_RS11065	COG0482	sulfurtransferase activity
EYR03_RS11080	COG0542	response to heat
EYR03_RS11105	COG0492	ferredoxin-NADP+ reductase activity
EYR03_RS11110	COG1674	ftsk spoiiie
EYR03_RS11135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EYR03_RS11155	COG0038	chloride channel
EYR03_RS11160	COG0183	Belongs to the thiolase family
EYR03_RS11165	COG1024	Enoyl-CoA hydratase
EYR03_RS11165	COG1250	3-hydroxyacyl-CoA dehydrogenase
EYR03_RS11180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EYR03_RS11200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EYR03_RS11205	COG1160	GTP binding
EYR03_RS11210	COG0303	'Molybdopterin
EYR03_RS11220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EYR03_RS11230	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS11255	COG0746	molybdenum cofactor guanylyltransferase activity
EYR03_RS11280	COG1648	precorrin-2 dehydrogenase activity
EYR03_RS11280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EYR03_RS11320	COG3039	Transposase
EYR03_RS11345	COG5001	Diguanylate cyclase
EYR03_RS11355	COG4566	intracellular signal transduction
EYR03_RS11500	COG1024	Enoyl-CoA hydratase
EYR03_RS11505	COG1024	Enoyl-CoA hydratase
EYR03_RS11515	COG1024	Enoyl-CoA hydratase
EYR03_RS11530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EYR03_RS11560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYR03_RS11565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYR03_RS11615	COG1858	cytochrome C peroxidase
EYR03_RS11645	COG0515	serine threonine protein kinase
EYR03_RS11650	COG0631	protein serine/threonine phosphatase activity
EYR03_RS11710	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS11725	COG3039	Transposase
EYR03_RS11810	COG3039	Transposase
EYR03_RS11825	COG2154	pterin-4-alpha-carbinolamine dehydratase
EYR03_RS11840	COG3064	Membrane
EYR03_RS11850	COG1530	ribonuclease E activity
EYR03_RS11865	COG1054	Belongs to the UPF0176 family
EYR03_RS11885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EYR03_RS11925	COG0322	excinuclease ABC activity
EYR03_RS11935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EYR03_RS11945	COG1663	tetraacyldisaccharide 4'-kinase activity
EYR03_RS11960	COG0811	peptide transport
EYR03_RS11985	COG4591	ABC-type transport system involved in lipoprotein release permease component
EYR03_RS12000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EYR03_RS12015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EYR03_RS12030	COG0354	folic acid binding
EYR03_RS12045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EYR03_RS12055	COG0363	glucosamine-6-phosphate deaminase activity
EYR03_RS12060	COG0129	dihydroxy-acid dehydratase activity
EYR03_RS12065	COG0800	Aldolase
EYR03_RS12145	COG0784	Response regulator, receiver
EYR03_RS12145	COG2205	protein histidine kinase activity
EYR03_RS12160	COG2183	response to ionizing radiation
EYR03_RS12170	COG0723	plastoquinol--plastocyanin reductase activity
EYR03_RS12170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYR03_RS12185	COG3243	poly(R)-hydroxyalkanoic acid synthase
EYR03_RS12195	COG1183	phosphatidylcholine synthase activity
EYR03_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS12215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EYR03_RS12225	COG0668	transmembrane transport
EYR03_RS12245	COG1914	H( )-stimulated, divalent metal cation uptake system
EYR03_RS12275	COG0583	DNA-binding transcription factor activity
EYR03_RS12300	COG0583	DNA-binding transcription factor activity
EYR03_RS12305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EYR03_RS12310	COG3002	Belongs to the UPF0753 family
EYR03_RS12315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EYR03_RS12315	COG0519	Catalyzes the synthesis of GMP from XMP
EYR03_RS12325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EYR03_RS12340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EYR03_RS12350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EYR03_RS12355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EYR03_RS12365	COG0776	regulation of translation
EYR03_RS12370	COG0539	negative regulation of cytoplasmic translation
EYR03_RS12375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EYR03_RS12390	COG2957	Belongs to the agmatine deiminase family
EYR03_RS12400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EYR03_RS12425	COG0395	ABC-type sugar transport system, permease component
EYR03_RS12430	COG1175	transmembrane transport
EYR03_RS12460	COG2350	Protein conserved in bacteria
EYR03_RS12465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EYR03_RS12470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EYR03_RS12475	COG1187	pseudouridine synthase activity
EYR03_RS12495	COG0436	Aminotransferase
EYR03_RS12500	COG4133	protoheme IX ABC transporter activity
EYR03_RS12560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EYR03_RS12565	COG4988	ABC transporter
EYR03_RS12575	COG1271	oxidase subunit
EYR03_RS12630	COG0165	Argininosuccinate lyase
EYR03_RS12645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EYR03_RS12650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYR03_RS12655	COG0137	argininosuccinate synthase activity
EYR03_RS12660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EYR03_RS12675	COG2166	iron-sulfur cluster assembly
EYR03_RS12700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EYR03_RS12715	COG4302	ethanolamine ammonia-lyase activity
EYR03_RS12730	COG4677	pectinesterase activity
EYR03_RS12755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EYR03_RS12760	COG0402	S-adenosylhomocysteine deaminase activity
EYR03_RS12780	COG1509	lysine 2,3-aminomutase activity
EYR03_RS12785	COG5001	Diguanylate cyclase
EYR03_RS12785	COG3300	MHYT domain
EYR03_RS12800	COG0483	inositol monophosphate 1-phosphatase activity
EYR03_RS12805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EYR03_RS12830	COG0488	(ABC) transporter
EYR03_RS12835	COG0513	Belongs to the DEAD box helicase family
EYR03_RS12845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EYR03_RS12855	COG0625	glutathione transferase activity
EYR03_RS12865	COG1671	Belongs to the UPF0178 family
EYR03_RS12870	COG4681	YaeQ
EYR03_RS12875	COG2081	HI0933 family
EYR03_RS12880	COG1716	ATPase activity
EYR03_RS12880	COG5001	Diguanylate cyclase
EYR03_RS12885	COG0501	Belongs to the peptidase M48B family
EYR03_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS12915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EYR03_RS12920	COG0860	N-Acetylmuramoyl-L-alanine amidase
EYR03_RS12925	COG0802	atpase or kinase
EYR03_RS12930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EYR03_RS12930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EYR03_RS12935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EYR03_RS12955	COG3039	Transposase
EYR03_RS12965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYR03_RS13010	COG0835	chemotaxis
EYR03_RS13015	COG0840	transmembrane signaling receptor activity
EYR03_RS13045	COG2969	positive regulation of protein catabolic process
EYR03_RS13050	COG0625	glutathione transferase activity
EYR03_RS13055	COG2857	Cytochrome c1
EYR03_RS13060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EYR03_RS13065	COG0723	plastoquinol--plastocyanin reductase activity
EYR03_RS13075	COG0741	lytic transglycosylase activity
EYR03_RS13105	COG1702	phosphate starvation-inducible protein PhoH
EYR03_RS13125	COG4535	Mg2 and Co2 transporter CorC
EYR03_RS13140	COG1012	belongs to the aldehyde dehydrogenase family
EYR03_RS13145	COG1177	transmembrane transport
EYR03_RS13150	COG1176	ABC-type spermidine putrescine transport system, permease component I
EYR03_RS13160	COG3842	ATPase activity
EYR03_RS13190	COG3039	Transposase
EYR03_RS13215	COG0174	glutamine synthetase
EYR03_RS13220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYR03_RS13230	COG0477	Major facilitator Superfamily
EYR03_RS13240	COG0243	molybdopterin cofactor binding
EYR03_RS13250	COG2223	nitrite transmembrane transporter activity
EYR03_RS13260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EYR03_RS13265	COG1121	(ABC) transporter
EYR03_RS13275	COG2733	membrane
EYR03_RS13290	COG3039	Transposase
EYR03_RS13300	COG0477	Major facilitator Superfamily
EYR03_RS13340	COG3039	Transposase
EYR03_RS13350	COG2902	Dehydrogenase
EYR03_RS13360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYR03_RS13365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYR03_RS13380	COG1609	Transcriptional regulator
EYR03_RS13385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EYR03_RS13385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EYR03_RS13390	COG1105	Belongs to the carbohydrate kinase PfkB family
EYR03_RS13395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EYR03_RS13395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EYR03_RS13445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EYR03_RS13455	COG1862	Preprotein translocase
EYR03_RS13460	COG0343	queuine tRNA-ribosyltransferase activity
EYR03_RS13525	COG0405	Gamma-glutamyltransferase
EYR03_RS13530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EYR03_RS13545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EYR03_RS13550	COG0742	ribosomal rna small subunit methyltransferase
EYR03_RS13555	COG0326	Molecular chaperone. Has ATPase activity
EYR03_RS13600	COG4206	TonB-dependent receptor
EYR03_RS13655	COG3039	Transposase
EYR03_RS13660	COG3039	Transposase
EYR03_RS13670	COG0531	amino acid
EYR03_RS13685	COG0006	proline dipeptidase activity
EYR03_RS13695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYR03_RS13710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYR03_RS13715	COG3938	Belongs to the proline racemase family
EYR03_RS13725	COG0552	protein localization to endoplasmic reticulum
EYR03_RS13740	COG1194	a g-specific adenine glycosylase
EYR03_RS13750	COG0784	Response regulator, receiver
EYR03_RS13750	COG4191	Histidine kinase
EYR03_RS13755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EYR03_RS13780	COG3040	lipid binding
EYR03_RS13790	COG1960	acyl-CoA dehydrogenase activity
EYR03_RS13800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EYR03_RS13830	COG0438	transferase activity, transferring glycosyl groups
EYR03_RS13840	COG0438	transferase activity, transferring glycosyl groups
EYR03_RS13845	COG0438	transferase activity, transferring glycosyl groups
EYR03_RS13900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EYR03_RS13915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EYR03_RS13940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EYR03_RS13955	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EYR03_RS13960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EYR03_RS13965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EYR03_RS13970	COG3115	cell septum assembly
EYR03_RS13990	COG0360	Binds together with S18 to 16S ribosomal RNA
EYR03_RS13995	COG0316	Belongs to the HesB IscA family
EYR03_RS14030	COG0288	reversible hydration of carbon dioxide
EYR03_RS14055	COG3844	kynureninase activity
EYR03_RS14065	COG2925	Exonuclease
EYR03_RS14075	COG0667	Aldo Keto reductase
EYR03_RS14105	COG0116	Belongs to the methyltransferase superfamily
EYR03_RS14105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EYR03_RS14150	COG0494	nUDIX hydrolase
EYR03_RS14160	COG1024	Enoyl-CoA hydratase
EYR03_RS14170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EYR03_RS14175	COG0659	secondary active sulfate transmembrane transporter activity
EYR03_RS14200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EYR03_RS14205	COG0573	inorganic phosphate transmembrane transporter activity
EYR03_RS14220	COG0704	Plays a role in the regulation of phosphate uptake
EYR03_RS14230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EYR03_RS14240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EYR03_RS14255	COG0557	exoribonuclease II activity
EYR03_RS14285	COG1960	acyl-CoA dehydrogenase activity
EYR03_RS14290	COG2226	methyltransferase
EYR03_RS14295	COG1410	methionine synthase
EYR03_RS14295	COG0646	methionine synthase
EYR03_RS14300	COG1410	methionine synthase
EYR03_RS14300	COG0646	methionine synthase
EYR03_RS14310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYR03_RS14320	COG1609	Transcriptional regulator
EYR03_RS14335	COG2900	Belongs to the SlyX family
EYR03_RS14350	COG0386	Belongs to the glutathione peroxidase family
EYR03_RS14360	COG1725	Transcriptional regulator
EYR03_RS14365	COG1131	(ABC) transporter
EYR03_RS14405	COG3039	Transposase
EYR03_RS14435	COG2850	peptidyl-arginine hydroxylation
EYR03_RS14470	COG1132	(ABC) transporter
EYR03_RS14500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EYR03_RS14510	COG0484	heat shock protein binding
EYR03_RS14515	COG0443	Heat shock 70 kDa protein
EYR03_RS14520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EYR03_RS14530	COG0497	DNA recombination
EYR03_RS14540	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EYR03_RS14550	COG2914	Belongs to the UPF0125 (RnfH) family
EYR03_RS14560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EYR03_RS14585	COG3039	Transposase
EYR03_RS14630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EYR03_RS14645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EYR03_RS14655	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EYR03_RS14660	COG0174	glutamine synthetase
EYR03_RS14725	COG0415	Belongs to the DNA photolyase family
EYR03_RS14730	COG0305	Participates in initiation and elongation during chromosome replication
EYR03_RS14740	COG0367	asparagine synthase
EYR03_RS14770	COG0084	hydrolase, TatD family'
EYR03_RS14775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EYR03_RS14815	COG0840	transmembrane signaling receptor activity
EYR03_RS14830	COG3039	Transposase
EYR03_RS14845	COG3039	Transposase
EYR03_RS14875	COG0386	Belongs to the glutathione peroxidase family
EYR03_RS14975	COG2814	Major facilitator Superfamily
EYR03_RS14980	COG1566	PFAM secretion protein HlyD family protein
EYR03_RS14995	COG2207	Transcriptional regulator
EYR03_RS15025	COG4774	siderophore transport
EYR03_RS15035	COG0367	asparagine synthase
EYR03_RS15040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYR03_RS15050	COG1393	Belongs to the ArsC family
EYR03_RS15110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EYR03_RS15125	COG0233	cytoplasmic translational termination
EYR03_RS15135	COG0575	Belongs to the CDS family
EYR03_RS15140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EYR03_RS15165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EYR03_RS15170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYR03_RS15190	COG0825	malonyl-CoA metabolic process
EYR03_RS15215	COG1981	membrane
EYR03_RS15265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EYR03_RS15280	COG2040	homocysteine
EYR03_RS15285	COG0833	amino acid
EYR03_RS15290	COG0346	lactoylglutathione lyase activity
EYR03_RS15300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYR03_RS15300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYR03_RS15310	COG2878	Part of a membrane complex involved in electron transport
EYR03_RS15330	COG1595	DNA-templated transcription, initiation
EYR03_RS15355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EYR03_RS15370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EYR03_RS15375	COG0251	oxidation-reduction process
EYR03_RS15385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EYR03_RS15385	COG0392	lysyltransferase activity
EYR03_RS15425	COG2814	Major facilitator Superfamily
EYR03_RS15430	COG1902	pentaerythritol trinitrate reductase activity
EYR03_RS15445	COG2824	Alkylphosphonate utilization operon protein PhnA
EYR03_RS15455	COG1047	Peptidyl-prolyl cis-trans
EYR03_RS15495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EYR03_RS15510	COG1451	nucleotide metabolic process
EYR03_RS15530	COG0183	Belongs to the thiolase family
EYR03_RS15560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EYR03_RS15560	COG1793	dna ligase
EYR03_RS15570	COG1793	dna ligase
EYR03_RS15575	COG1201	RNA secondary structure unwinding
EYR03_RS15595	COG1278	Cold shock
EYR03_RS15600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EYR03_RS15615	COG3046	protein related to deoxyribodipyrimidine photolyase
EYR03_RS15620	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
EYR03_RS15630	COG2954	triphosphatase activity
EYR03_RS15645	COG1381	Involved in DNA repair and RecF pathway recombination
EYR03_RS15675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYR03_RS15690	COG1250	3-hydroxyacyl-CoA dehydrogenase
EYR03_RS15690	COG1024	Enoyl-CoA hydratase
EYR03_RS15710	COG1024	Enoyl-CoA hydratase
EYR03_RS15715	COG1960	acyl-CoA dehydrogenase activity
EYR03_RS15790	COG2353	YceI-like domain
EYR03_RS15815	COG1760	l-serine dehydratase
EYR03_RS15825	COG0626	cystathionine gamma-synthase activity
EYR03_RS15830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EYR03_RS15835	COG0739	heme binding
EYR03_RS15845	COG1272	protein, Hemolysin III
EYR03_RS15865	COG0517	IMP dehydrogenase activity
EYR03_RS15865	COG0516	GMP reductase activity
EYR03_RS15870	COG0463	Glycosyl transferase, family 2
EYR03_RS15880	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EYR03_RS15890	COG4771	TonB-dependent receptor
EYR03_RS15895	COG1309	transcriptional regulator
EYR03_RS15905	COG1960	acyl-CoA dehydrogenase activity
EYR03_RS15935	COG0509	glycine decarboxylation via glycine cleavage system
EYR03_RS15950	COG0330	HflC and HflK could
EYR03_RS15960	COG1742	UPF0060 membrane protein
EYR03_RS15965	COG3956	TIGRFAM MazG family protein
EYR03_RS15975	COG0494	nUDIX hydrolase
EYR03_RS15985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EYR03_RS15990	COG0837	glucose binding
EYR03_RS16005	COG1388	LysM domain
EYR03_RS16005	COG3858	chitin binding
EYR03_RS16025	COG1472	Belongs to the glycosyl hydrolase 3 family
EYR03_RS16055	COG3039	Transposase
EYR03_RS16105	COG3537	Alpha-1,2-mannosidase
EYR03_RS16150	COG3142	Participates in the control of copper homeostasis
EYR03_RS16155	COG1446	asparaginase
EYR03_RS16165	COG2304	oxidoreductase activity
EYR03_RS16190	COG0643	Histidine kinase
EYR03_RS16190	COG2198	Histidine kinase
EYR03_RS16190	COG0784	Response regulator, receiver
EYR03_RS16195	COG0840	transmembrane signaling receptor activity
EYR03_RS16200	COG0835	chemotaxis
EYR03_RS16215	COG0189	ligase activity
EYR03_RS16225	COG1397	ADP-ribosylglycohydrolase
EYR03_RS16235	COG1199	ATP-dependent helicase activity
EYR03_RS16245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EYR03_RS16250	COG1215	transferase activity, transferring glycosyl groups
EYR03_RS16310	COG1643	Atp-dependent helicase
EYR03_RS16315	COG0783	Belongs to the Dps family
EYR03_RS16325	COG0514	ATP-dependent DNA helicase (RecQ)
EYR03_RS16340	COG3039	Transposase
EYR03_RS16355	COG1187	pseudouridine synthase activity
EYR03_RS16395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EYR03_RS16405	COG0602	queuosine metabolic process
EYR03_RS16415	COG2885	chlorophyll binding
EYR03_RS16420	COG0823	Involved in the tonB-independent uptake of proteins
EYR03_RS16430	COG0848	biopolymer transport protein
EYR03_RS16440	COG0824	Thioesterase
EYR03_RS16445	COG2255	four-way junction helicase activity
EYR03_RS16460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EYR03_RS16485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EYR03_RS16500	COG0477	Major facilitator Superfamily
EYR03_RS16535	COG0488	(ABC) transporter
EYR03_RS16565	COG4651	solute:proton antiporter activity
EYR03_RS16565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EYR03_RS16610	COG4772	TonB-dependent receptor
EYR03_RS16620	COG4264	IucA IucC family
EYR03_RS16625	COG2814	Major facilitator Superfamily
EYR03_RS16635	COG0019	diaminopimelate decarboxylase activity
EYR03_RS16690	COG4206	TonB-dependent receptor
EYR03_RS16725	COG0542	response to heat
EYR03_RS16750	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EYR03_RS16760	COG0534	Mate efflux family protein
EYR03_RS16775	COG0336	Belongs to the RNA methyltransferase TrmD family
EYR03_RS16780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EYR03_RS16785	COG0228	four-way junction DNA binding
EYR03_RS16810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EYR03_RS16820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EYR03_RS16860	COG2172	sigma factor antagonist activity
EYR03_RS16865	COG1366	Belongs to the anti-sigma-factor antagonist family
EYR03_RS16870	COG1366	Belongs to the anti-sigma-factor antagonist family
EYR03_RS16880	COG0326	Molecular chaperone. Has ATPase activity
EYR03_RS16885	COG2207	Transcriptional regulator
EYR03_RS16940	COG3209	COG3209 Rhs family protein
EYR03_RS16955	COG3209	COG3209 Rhs family protein
EYR03_RS16975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EYR03_RS16980	COG1845	cytochrome c oxidase, subunit III
EYR03_RS16985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EYR03_RS17000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EYR03_RS17005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EYR03_RS17020	COG0728	peptidoglycan biosynthetic process
EYR03_RS17025	COG0268	Binds directly to 16S ribosomal RNA
EYR03_RS17030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EYR03_RS17035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EYR03_RS17045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EYR03_RS17050	COG0824	Thioesterase
EYR03_RS17065	COG1946	Acyl-CoA thioesterase
EYR03_RS17075	COG1595	DNA-templated transcription, initiation
EYR03_RS17090	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EYR03_RS17130	COG1877	trehalose-phosphatase activity
EYR03_RS17135	COG3387	PFAM Glycoside hydrolase 15-related
EYR03_RS17170	COG0564	pseudouridine synthase activity
EYR03_RS17175	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EYR03_RS17180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EYR03_RS17180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EYR03_RS17195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EYR03_RS17200	COG0045	succinate-CoA ligase (ADP-forming) activity
EYR03_RS17240	COG2194	sulfuric ester hydrolase activity
EYR03_RS17245	COG4969	Belongs to the N-Me-Phe pilin family
EYR03_RS17255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EYR03_RS17260	COG0237	dephospho-CoA kinase activity
EYR03_RS17265	COG2205	protein histidine kinase activity
EYR03_RS17270	COG0745	RESPONSE REGULATOR receiver
EYR03_RS17290	COG3039	Transposase
EYR03_RS17315	COG3039	Transposase
EYR03_RS17330	COG2801	Transposase and inactivated derivatives
EYR03_RS17340	COG3039	Transposase
EYR03_RS17365	COG2022	thiamine diphosphate biosynthetic process
EYR03_RS17380	COG3273	potassium ion transport
EYR03_RS17380	COG0471	metal ion transport
EYR03_RS17410	COG1970	mechanosensitive ion channel activity
EYR03_RS17445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EYR03_RS17460	COG0308	aminopeptidase N
EYR03_RS17465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYR03_RS17475	COG0529	Catalyzes the synthesis of activated sulfate
EYR03_RS17475	COG2895	sulfate adenylyltransferase (ATP) activity
EYR03_RS17480	COG0175	sulfate reduction
EYR03_RS17485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EYR03_RS17490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EYR03_RS17495	COG0175	sulfate reduction
EYR03_RS17515	COG2198	Histidine kinase
EYR03_RS17515	COG2205	protein histidine kinase activity
EYR03_RS17515	COG0784	Response regulator, receiver
EYR03_RS17560	COG3588	fructose-bisphosphate aldolase
EYR03_RS17570	COG0469	pyruvate kinase activity
EYR03_RS17595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EYR03_RS17605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EYR03_RS17605	COG3453	Protein conserved in bacteria
EYR03_RS17610	COG0725	ABC transporter, periplasmic molybdate-binding protein
EYR03_RS17615	COG4149	molybdate abc transporter
EYR03_RS17620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EYR03_RS17640	COG0642	Histidine kinase
EYR03_RS17655	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS17665	COG1022	Amp-dependent synthetase and ligase
EYR03_RS17690	COG1376	ErfK ybiS ycfS ynhG family protein
EYR03_RS17695	COG0739	heme binding
EYR03_RS17710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EYR03_RS17715	COG1301	dicarboxylic acid transport
EYR03_RS17735	COG2304	oxidoreductase activity
EYR03_RS17755	COG0714	Associated with various cellular activities
EYR03_RS17790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EYR03_RS17825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EYR03_RS17835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EYR03_RS17855	COG1561	YicC-like family, N-terminal region
EYR03_RS17860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EYR03_RS17875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EYR03_RS17905	COG0006	proline dipeptidase activity
EYR03_RS17950	COG2912	Transglutaminase-like superfamily
EYR03_RS17955	COG1773	rubredoxin
EYR03_RS17960	COG0352	thiamine-phosphate diphosphorylase activity
EYR03_RS17970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EYR03_RS17985	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EYR03_RS18030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EYR03_RS18055	COG0671	phosphoesterase, PA-phosphatase related
EYR03_RS18070	COG3781	membrane
EYR03_RS18080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EYR03_RS18100	COG3039	Transposase
EYR03_RS18115	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EYR03_RS18125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EYR03_RS18150	COG3710	Transcriptional regulator
EYR03_RS18155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EYR03_RS18165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EYR03_RS18195	COG2226	methyltransferase
EYR03_RS18200	COG0066	3-isopropylmalate dehydratase activity
EYR03_RS18205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EYR03_RS18225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EYR03_RS18230	COG1538	Outer membrane efflux protein
EYR03_RS18235	COG1519	Transferase
EYR03_RS18240	COG1560	Kdo2-lipid A biosynthetic process
EYR03_RS18260	COG3039	Transposase
EYR03_RS18335	COG3039	Transposase
EYR03_RS18350	COG0280	phosphate acetyltransferase
EYR03_RS18350	COG0281	malic enzyme
EYR03_RS18370	COG4191	Histidine kinase
EYR03_RS18385	COG0583	DNA-binding transcription factor activity
EYR03_RS18410	COG2197	response regulator
EYR03_RS18420	COG0642	Histidine kinase
EYR03_RS18440	COG2851	Citrate transporter
EYR03_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS18455	COG1609	Transcriptional regulator
EYR03_RS18465	COG2211	Major facilitator Superfamily
EYR03_RS18495	COG0436	Aminotransferase
EYR03_RS18515	COG0726	polysaccharide deacetylase
EYR03_RS18520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EYR03_RS18540	COG0402	S-adenosylhomocysteine deaminase activity
EYR03_RS18590	COG0242	peptide deformylase activity
EYR03_RS18595	COG3039	Transposase
EYR03_RS18630	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EYR03_RS18690	COG2188	Transcriptional regulator
EYR03_RS18705	COG1450	Type ii and iii secretion system protein
EYR03_RS18720	COG3166	PFAM Fimbrial assembly family protein
EYR03_RS18725	COG3156	type II secretion system protein K
EYR03_RS18730	COG4795	General secretion pathway protein
EYR03_RS18735	COG2165	general secretion pathway protein
EYR03_RS18740	COG4970	Tfp pilus assembly protein FimT
EYR03_RS18745	COG2165	general secretion pathway protein
EYR03_RS18750	COG1459	type II secretion system
EYR03_RS18760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EYR03_RS18765	COG1404	Belongs to the peptidase S8 family
EYR03_RS18770	COG5295	Hep Hag repeat protein
EYR03_RS18780	COG0047	phosphoribosylformylglycinamidine synthase activity
EYR03_RS18780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EYR03_RS18790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EYR03_RS18795	COG4974	Belongs to the 'phage' integrase family
EYR03_RS18810	COG0795	lipopolysaccharide-transporting ATPase activity
EYR03_RS18820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EYR03_RS18845	COG0525	valine-tRNA ligase activity
EYR03_RS18875	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS18885	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS18905	COG1183	phosphatidylcholine synthase activity
EYR03_RS18915	COG0442	prolyl-tRNA aminoacylation
EYR03_RS18930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EYR03_RS18935	COG1127	ABC transporter
EYR03_RS18940	COG3218	ABC-type transport auxiliary lipoprotein component
EYR03_RS18940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EYR03_RS18985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EYR03_RS18990	COG0662	Cupin 2, conserved barrel domain protein
EYR03_RS18990	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EYR03_RS19020	COG2086	electron transfer activity
EYR03_RS19095	COG0626	cystathionine gamma-synthase activity
EYR03_RS19125	COG0625	glutathione transferase activity
EYR03_RS19140	COG0513	Belongs to the DEAD box helicase family
EYR03_RS19150	COG0720	synthase
EYR03_RS19160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EYR03_RS19165	COG1956	GAF domain-containing protein
EYR03_RS19175	COG0546	phosphoglycolate phosphatase activity
EYR03_RS19205	COG0339	signal peptide processing
EYR03_RS19255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EYR03_RS19320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EYR03_RS19325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EYR03_RS19330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EYR03_RS19340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EYR03_RS19350	COG0356	it plays a direct role in the translocation of protons across the membrane
EYR03_RS19370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EYR03_RS19380	COG0508	dehydrogenase complex catalyzes the overall conversion of
EYR03_RS19415	COG2011	ABC-type metal ion transport system permease component
EYR03_RS19425	COG0697	spore germination
EYR03_RS19460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EYR03_RS19465	COG1187	pseudouridine synthase activity
EYR03_RS19470	COG2813	Specifically methylates the guanine in position
EYR03_RS19500	COG2205	protein histidine kinase activity
EYR03_RS19500	COG2202	Pas domain
EYR03_RS19525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYR03_RS19575	COG0745	RESPONSE REGULATOR receiver
EYR03_RS19590	COG1404	Belongs to the peptidase S8 family
EYR03_RS19605	COG0842	Transport permease protein
EYR03_RS19610	COG1131	(ABC) transporter
EYR03_RS19615	COG0025	NhaP-type Na H and K H
EYR03_RS19625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EYR03_RS19635	COG1573	uracil-dna glycosylase
EYR03_RS19645	COG3384	dioxygenase
EYR03_RS19670	COG3590	peptidase
EYR03_RS19690	COG0531	amino acid
EYR03_RS19715	COG3685	Protein conserved in bacteria
EYR03_RS19720	COG3546	catalase activity
EYR03_RS19745	COG3039	Transposase
EYR03_RS19775	COG1271	oxidase subunit
EYR03_RS19780	COG1294	oxidase, subunit
EYR03_RS19810	COG1063	alcohol dehydrogenase
EYR03_RS19905	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EYR03_RS19905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EYR03_RS19915	COG1473	amidohydrolase
EYR03_RS19920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYR03_RS19925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYR03_RS19950	COG5383	Protein conserved in bacteria
EYR03_RS20005	COG3023	N-Acetylmuramoyl-L-alanine amidase
EYR03_RS20015	COG4948	Mandelate Racemase Muconate Lactonizing
EYR03_RS20045	COG0531	amino acid
EYR03_RS20065	COG4682	membrane
EYR03_RS20070	COG2133	pyrroloquinoline quinone binding
EYR03_RS20090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EYR03_RS20095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EYR03_RS20110	COG1610	YqeY-like protein
EYR03_RS20130	COG1295	ribonuclease BN
EYR03_RS20135	COG0358	DNA primase activity
EYR03_RS20200	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EYR03_RS20215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EYR03_RS20280	COG0739	heme binding
EYR03_RS20295	COG2211	Major facilitator Superfamily
EYR03_RS20300	COG0708	Exodeoxyribonuclease III
EYR03_RS20315	COG1192	Involved in chromosome partitioning
EYR03_RS20320	COG1475	DNA binding
EYR03_RS20340	COG0463	Glycosyl transferase, family 2
EYR03_RS20365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EYR03_RS20390	COG4221	oxidoreductase activity
EYR03_RS20435	COG1166	arginine decarboxylase activity
EYR03_RS20440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EYR03_RS20485	COG0606	chelatase, subunit chli
EYR03_RS20530	COG3039	Transposase
EYR03_RS20590	COG1090	epimerase
EYR03_RS20600	COG0642	Histidine kinase
EYR03_RS20615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYR03_RS20650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EYR03_RS20660	COG1595	DNA-templated transcription, initiation
EYR03_RS20665	COG0753	catalase activity
EYR03_RS20690	COG0697	spore germination
EYR03_RS20715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EYR03_RS20720	COG0180	Tryptophanyl-tRNA synthetase
EYR03_RS20725	COG3237	CsbD-like
EYR03_RS20740	COG0010	Belongs to the arginase family
EYR03_RS20760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EYR03_RS20775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EYR03_RS20780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EYR03_RS20780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EYR03_RS20790	COG3228	Belongs to the MtfA family
EYR03_RS20820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EYR03_RS20875	COG3039	Transposase
EYR03_RS20880	COG1566	PFAM secretion protein HlyD family protein
EYR03_RS20895	COG1199	ATP-dependent helicase activity
EYR03_RS20940	COG0583	DNA-binding transcription factor activity
EYR03_RS20985	COG0625	glutathione transferase activity
EYR03_RS20995	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS21025	COG4555	ABC transporter
EYR03_RS21035	COG1476	TRANSCRIPTIONal
EYR03_RS21055	COG1230	cation diffusion facilitator family transporter
EYR03_RS21060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EYR03_RS21065	COG1131	(ABC) transporter
EYR03_RS21070	COG0842	Transport permease protein
EYR03_RS21080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EYR03_RS21115	COG2951	lytic endotransglycosylase activity
EYR03_RS21130	COG1196	nuclear chromosome segregation
EYR03_RS21135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EYR03_RS21145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EYR03_RS21160	COG0045	succinate-CoA ligase (ADP-forming) activity
EYR03_RS21160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EYR03_RS21160	COG1042	CoA-binding domain protein
EYR03_RS21170	COG2239	Acts as a magnesium transporter
EYR03_RS21195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EYR03_RS21200	COG3387	PFAM Glycoside hydrolase 15-related
EYR03_RS21215	COG3100	YcgL domain-containing protein
EYR03_RS21220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EYR03_RS21230	COG0463	Glycosyl transferase, family 2
EYR03_RS21240	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS21270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EYR03_RS21285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EYR03_RS21335	COG0408	coproporphyrinogen oxidase activity
EYR03_RS21415	COG0210	DNA helicase
EYR03_RS21435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EYR03_RS21450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EYR03_RS21465	COG2159	amidohydrolase
EYR03_RS21500	COG3540	Alkaline phosphatase
EYR03_RS21510	COG2091	lysine biosynthetic process via aminoadipic acid
EYR03_RS21525	COG0708	Exodeoxyribonuclease III
EYR03_RS21545	COG3162	membrane
EYR03_RS21600	COG1028	Short-chain dehydrogenase reductase Sdr
EYR03_RS21605	COG0179	Fumarylacetoacetate (FAA) hydrolase
EYR03_RS21615	COG4948	Mandelate Racemase Muconate Lactonizing
EYR03_RS21620	COG3254	rhamnose metabolic process
EYR03_RS21625	COG0738	Major facilitator superfamily
EYR03_RS21630	COG1414	Transcriptional regulator
EYR03_RS21640	COG2205	protein histidine kinase activity
EYR03_RS21650	COG3459	Glycosyltransferase 36 associated
EYR03_RS21655	COG2211	Major facilitator Superfamily
EYR03_RS21660	COG3265	gluconokinase activity
EYR03_RS21665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EYR03_RS21690	COG2801	Transposase and inactivated derivatives
EYR03_RS21695	COG3039	Transposase
EYR03_RS21705	COG3039	Transposase
EYR03_RS21710	COG2911	Protein conserved in bacteria
EYR03_RS21715	COG0729	surface antigen
EYR03_RS21725	COG0457	Tetratricopeptide repeat
EYR03_RS21740	COG0752	glycyl-tRNA synthetase alpha subunit
EYR03_RS21745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EYR03_RS21765	COG0805	protein transport
EYR03_RS21770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EYR03_RS21775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EYR03_RS21785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EYR03_RS21815	COG2974	May be involved in recombination
EYR03_RS21820	COG0037	tRNA processing
EYR03_RS21845	COG3661	Belongs to the glycosyl hydrolase 67 family
EYR03_RS21855	COG4948	Mandelate Racemase Muconate Lactonizing
EYR03_RS21865	COG1472	Belongs to the glycosyl hydrolase 3 family
EYR03_RS21870	COG0246	Mannitol dehydrogenase
EYR03_RS21905	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS21930	COG3693	PFAM glycoside hydrolase, family 10
EYR03_RS21955	COG2211	Major facilitator Superfamily
EYR03_RS21970	COG3039	Transposase
EYR03_RS22000	COG2937	Belongs to the GPAT DAPAT family
EYR03_RS22035	COG0284	orotidine-5'-phosphate decarboxylase activity
EYR03_RS22040	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EYR03_RS22045	COG3132	Protein of unknown function, DUF480
EYR03_RS22060	COG0210	DNA helicase
EYR03_RS22075	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EYR03_RS22085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EYR03_RS22140	COG0676	glucose-6-phosphate 1-epimerase activity
EYR03_RS22155	COG0730	response to heat
EYR03_RS22190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EYR03_RS22195	COG0302	gtp cyclohydrolase
EYR03_RS22225	COG2826	transposase and inactivated derivatives, IS30 family
EYR03_RS22235	COG0477	Major facilitator Superfamily
EYR03_RS22250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EYR03_RS22295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EYR03_RS22345	COG3237	CsbD-like
EYR03_RS22370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYR03_RS22400	COG1304	FMN binding
EYR03_RS22425	COG4772	TonB-dependent receptor
EYR03_RS22435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EYR03_RS22465	COG3039	Transposase
EYR03_RS22520	COG0564	pseudouridine synthase activity
EYR03_RS22535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EYR03_RS22550	COG3039	Transposase
EYR03_RS22570	COG3039	Transposase
EYR03_RS22595	COG3039	Transposase
EYR03_RS22675	COG1074	ATP-dependent DNA helicase activity
EYR03_RS22680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EYR03_RS22685	COG1116	anion transmembrane transporter activity
EYR03_RS22695	COG3039	Transposase
EYR03_RS22700	COG3039	Transposase
EYR03_RS22710	COG1136	(ABC) transporter
EYR03_RS22730	COG1127	ABC transporter
EYR03_RS22735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EYR03_RS22740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EYR03_RS22755	COG2853	Lipoprotein
EYR03_RS22775	COG0386	Belongs to the glutathione peroxidase family
EYR03_RS22785	COG1322	Protein conserved in bacteria
EYR03_RS22790	COG3039	Transposase
EYR03_RS22815	COG1929	Belongs to the glycerate kinase type-1 family
EYR03_RS22820	COG2271	Major facilitator Superfamily
EYR03_RS22835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EYR03_RS22845	COG0861	Integral membrane protein TerC family
EYR03_RS22855	COG0584	glycerophosphoryl diester phosphodiesterase
EYR03_RS22865	COG0671	phosphoesterase, PA-phosphatase related
EYR03_RS22870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EYR03_RS22875	COG0726	polysaccharide deacetylase