locus-tag	class	description
BXU04_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BXU04_RS00020	COG0187	DNA topoisomerase II activity
BXU04_RS00030	COG0501	Belongs to the peptidase M48B family
BXU04_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BXU04_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BXU04_RS00090	COG4772	TonB-dependent receptor
BXU04_RS00105	COG3039	Transposase
BXU04_RS00110	COG1304	FMN binding
BXU04_RS00115	COG1755	Isoprenylcysteine carboxyl methyltransferase
BXU04_RS00140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BXU04_RS00155	COG3039	Transposase
BXU04_RS00165	COG1116	anion transmembrane transporter activity
BXU04_RS00205	COG3039	Transposase
BXU04_RS00210	COG0513	Belongs to the DEAD box helicase family
BXU04_RS00260	COG3039	Transposase
BXU04_RS00305	COG1858	cytochrome C peroxidase
BXU04_RS00320	COG0702	epimerase
BXU04_RS00345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BXU04_RS00365	COG1649	PFAM Uncharacterised BCR, COG1649
BXU04_RS00370	COG2354	Protein conserved in bacteria
BXU04_RS00375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BXU04_RS00390	COG1511	domain protein
BXU04_RS00390	COG3264	Mechanosensitive ion channel
BXU04_RS00465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BXU04_RS00570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BXU04_RS00590	COG1090	epimerase
BXU04_RS00600	COG3039	Transposase
BXU04_RS00625	COG2826	transposase and inactivated derivatives, IS30 family
BXU04_RS00685	COG1136	(ABC) transporter
BXU04_RS00725	COG1272	protein, Hemolysin III
BXU04_RS00730	COG1111	helicase
BXU04_RS00730	COG1205	dead DEAH box helicase
BXU04_RS00790	COG0070	glutamate synthase
BXU04_RS00790	COG0069	glutamate synthase activity
BXU04_RS00790	COG0067	glutamate synthase
BXU04_RS00795	COG0493	'glutamate synthase
BXU04_RS00855	COG1609	Transcriptional regulator
BXU04_RS00880	COG0366	Alpha amylase catalytic
BXU04_RS00885	COG0366	Alpha amylase catalytic
BXU04_RS00930	COG0606	chelatase, subunit chli
BXU04_RS00970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BXU04_RS00975	COG1166	arginine decarboxylase activity
BXU04_RS01060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BXU04_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS01110	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BXU04_RS01125	COG0210	DNA helicase
BXU04_RS01140	COG3132	Protein of unknown function, DUF480
BXU04_RS01145	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BXU04_RS01150	COG0284	orotidine-5'-phosphate decarboxylase activity
BXU04_RS01185	COG2937	Belongs to the GPAT DAPAT family
BXU04_RS01225	COG3186	Phenylalanine-4-hydroxylase
BXU04_RS01230	COG1522	sequence-specific DNA binding
BXU04_RS01275	COG1064	alcohol dehydrogenase
BXU04_RS01280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BXU04_RS01290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BXU04_RS01300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BXU04_RS01325	COG3039	Transposase
BXU04_RS01330	COG0676	glucose-6-phosphate 1-epimerase activity
BXU04_RS01395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BXU04_RS01415	COG2853	Lipoprotein
BXU04_RS01430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BXU04_RS01435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BXU04_RS01440	COG1127	ABC transporter
BXU04_RS01515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BXU04_RS01525	COG3265	gluconokinase activity
BXU04_RS01530	COG2211	Major facilitator Superfamily
BXU04_RS01535	COG3459	Glycosyltransferase 36 associated
BXU04_RS01545	COG2205	protein histidine kinase activity
BXU04_RS01555	COG1414	Transcriptional regulator
BXU04_RS01560	COG0738	Major facilitator superfamily
BXU04_RS01565	COG3254	rhamnose metabolic process
BXU04_RS01595	COG0339	signal peptide processing
BXU04_RS01625	COG0564	pseudouridine synthase activity
BXU04_RS01635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BXU04_RS01715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BXU04_RS01725	COG0842	Transport permease protein
BXU04_RS01730	COG1131	(ABC) transporter
BXU04_RS01735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BXU04_RS01760	COG1476	TRANSCRIPTIONal
BXU04_RS01770	COG4555	ABC transporter
BXU04_RS01805	COG0625	glutathione transferase activity
BXU04_RS01850	COG0583	DNA-binding transcription factor activity
BXU04_RS01890	COG1199	ATP-dependent helicase activity
BXU04_RS01930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BXU04_RS01960	COG3228	Belongs to the MtfA family
BXU04_RS01970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BXU04_RS01970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BXU04_RS01975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BXU04_RS01990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BXU04_RS02025	COG3237	CsbD-like
BXU04_RS02030	COG0180	Tryptophanyl-tRNA synthetase
BXU04_RS02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BXU04_RS02080	COG0753	catalase activity
BXU04_RS02085	COG1595	DNA-templated transcription, initiation
BXU04_RS02095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BXU04_RS02105	COG0628	permease
BXU04_RS02115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BXU04_RS02120	COG1040	competence protein
BXU04_RS02125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BXU04_RS02130	COG0156	8-amino-7-oxononanoate synthase activity
BXU04_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS02155	COG0463	Glycosyl transferase, family 2
BXU04_RS02165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BXU04_RS02170	COG3100	YcgL domain-containing protein
BXU04_RS02185	COG3387	PFAM Glycoside hydrolase 15-related
BXU04_RS02190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BXU04_RS02205	COG2239	Acts as a magnesium transporter
BXU04_RS02215	COG0045	succinate-CoA ligase (ADP-forming) activity
BXU04_RS02215	COG1042	CoA-binding domain protein
BXU04_RS02215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BXU04_RS02225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BXU04_RS02230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BXU04_RS02265	COG3485	protocatechuate 3,4-dioxygenase
BXU04_RS02270	COG3485	protocatechuate 3,4-dioxygenase
BXU04_RS02280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BXU04_RS02285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BXU04_RS02290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BXU04_RS02315	COG4221	oxidoreductase activity
BXU04_RS02330	COG0018	arginyl-trna synthetase
BXU04_RS02335	COG2003	Belongs to the UPF0758 family
BXU04_RS02340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BXU04_RS02365	COG0463	Glycosyl transferase, family 2
BXU04_RS02380	COG1475	DNA binding
BXU04_RS02385	COG1192	Involved in chromosome partitioning
BXU04_RS02400	COG0708	Exodeoxyribonuclease III
BXU04_RS02405	COG2211	Major facilitator Superfamily
BXU04_RS02420	COG0739	heme binding
BXU04_RS02465	COG0745	RESPONSE REGULATOR receiver
BXU04_RS02505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BXU04_RS02520	COG2814	Major facilitator Superfamily
BXU04_RS02535	COG1289	transmembrane transporter activity
BXU04_RS02545	COG0577	efflux transmembrane transporter activity
BXU04_RS02545	COG1136	(ABC) transporter
BXU04_RS02550	COG0151	Belongs to the GarS family
BXU04_RS02560	COG0419	ATPase involved in DNA repair
BXU04_RS02595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BXU04_RS02635	COG0439	Biotin carboxylase
BXU04_RS02645	COG0511	ligase activity, forming carbon-carbon bonds
BXU04_RS02650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BXU04_RS02660	COG1324	tolerance protein
BXU04_RS02695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BXU04_RS02715	COG0534	Mate efflux family protein
BXU04_RS02720	COG0616	signal peptide processing
BXU04_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS02745	COG0009	L-threonylcarbamoyladenylate synthase
BXU04_RS02750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BXU04_RS02750	COG1754	DNA topoisomerase type I activity
BXU04_RS02765	COG2922	Belongs to the Smg family
BXU04_RS02770	COG0758	DNA mediated transformation
BXU04_RS02775	COG1652	LysM domain
BXU04_RS02780	COG0242	peptide deformylase activity
BXU04_RS02785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BXU04_RS02790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BXU04_RS02790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BXU04_RS02840	COG1560	Kdo2-lipid A biosynthetic process
BXU04_RS02850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BXU04_RS03075	COG1294	oxidase, subunit
BXU04_RS03080	COG1271	oxidase subunit
BXU04_RS03090	COG2204	response regulator
BXU04_RS03115	COG2972	Histidine kinase
BXU04_RS03130	COG0531	amino acid
BXU04_RS03150	COG3590	peptidase
BXU04_RS03165	COG0667	Aldo Keto reductase
BXU04_RS03180	COG3384	dioxygenase
BXU04_RS03190	COG1573	uracil-dna glycosylase
BXU04_RS03200	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BXU04_RS03215	COG0025	NhaP-type Na H and K H
BXU04_RS03220	COG1131	(ABC) transporter
BXU04_RS03225	COG0842	Transport permease protein
BXU04_RS03245	COG1404	Belongs to the peptidase S8 family
BXU04_RS03260	COG0745	RESPONSE REGULATOR receiver
BXU04_RS03310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BXU04_RS03335	COG2202	Pas domain
BXU04_RS03335	COG2205	protein histidine kinase activity
BXU04_RS03365	COG2813	Specifically methylates the guanine in position
BXU04_RS03370	COG1187	pseudouridine synthase activity
BXU04_RS03375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BXU04_RS03410	COG0697	spore germination
BXU04_RS03420	COG2011	ABC-type metal ion transport system permease component
BXU04_RS03450	COG0508	dehydrogenase complex catalyzes the overall conversion of
BXU04_RS03460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BXU04_RS03480	COG0356	it plays a direct role in the translocation of protons across the membrane
BXU04_RS03490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BXU04_RS03500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BXU04_RS03505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BXU04_RS03510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BXU04_RS03515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BXU04_RS03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BXU04_RS03570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BXU04_RS03625	COG0339	signal peptide processing
BXU04_RS03660	COG1956	GAF domain-containing protein
BXU04_RS03665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BXU04_RS03675	COG0720	synthase
BXU04_RS03680	COG0513	Belongs to the DEAD box helicase family
BXU04_RS03720	COG0626	cystathionine gamma-synthase activity
BXU04_RS03760	COG3328	transposase activity
BXU04_RS03785	COG2086	electron transfer activity
BXU04_RS03810	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BXU04_RS03810	COG0662	Cupin 2, conserved barrel domain protein
BXU04_RS03815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BXU04_RS03850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BXU04_RS03850	COG3218	ABC-type transport auxiliary lipoprotein component
BXU04_RS03855	COG1127	ABC transporter
BXU04_RS03860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BXU04_RS03875	COG0442	prolyl-tRNA aminoacylation
BXU04_RS03885	COG1183	phosphatidylcholine synthase activity
BXU04_RS03910	COG3039	Transposase
BXU04_RS03965	COG0525	valine-tRNA ligase activity
BXU04_RS03980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BXU04_RS03990	COG0795	lipopolysaccharide-transporting ATPase activity
BXU04_RS04005	COG4974	Belongs to the 'phage' integrase family
BXU04_RS04010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BXU04_RS04015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BXU04_RS04015	COG0047	phosphoribosylformylglycinamidine synthase activity
BXU04_RS04020	COG5295	Hep Hag repeat protein
BXU04_RS04040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BXU04_RS04050	COG1459	type II secretion system
BXU04_RS04055	COG2165	general secretion pathway protein
BXU04_RS04060	COG4970	Tfp pilus assembly protein FimT
BXU04_RS04065	COG2165	general secretion pathway protein
BXU04_RS04070	COG4795	General secretion pathway protein
BXU04_RS04075	COG3156	type II secretion system protein K
BXU04_RS04080	COG3166	PFAM Fimbrial assembly family protein
BXU04_RS04095	COG1450	Type ii and iii secretion system protein
BXU04_RS04110	COG2188	Transcriptional regulator
BXU04_RS04155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BXU04_RS04160	COG1518	maintenance of DNA repeat elements
BXU04_RS04200	COG1399	metal-binding, possibly nucleic acid-binding protein
BXU04_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS04230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BXU04_RS04240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BXU04_RS04245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BXU04_RS04280	COG3829	transcription factor binding
BXU04_RS04310	COG3039	Transposase
BXU04_RS04360	COG2826	transposase and inactivated derivatives, IS30 family
BXU04_RS04370	COG0678	peroxiredoxin activity
BXU04_RS04390	COG0330	HflC and HflK could
BXU04_RS04395	COG0330	HflC and HflK could
BXU04_RS04410	COG0308	aminopeptidase N
BXU04_RS04445	COG3039	Transposase
BXU04_RS04465	COG1560	Kdo2-lipid A biosynthetic process
BXU04_RS04470	COG1519	Transferase
BXU04_RS04475	COG1538	Outer membrane efflux protein
BXU04_RS04480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BXU04_RS04510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BXU04_RS04515	COG0066	3-isopropylmalate dehydratase activity
BXU04_RS04550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BXU04_RS04560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BXU04_RS04565	COG3710	Transcriptional regulator
BXU04_RS04590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BXU04_RS04610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BXU04_RS04640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BXU04_RS04650	COG3781	membrane
BXU04_RS04665	COG0625	glutathione transferase activity
BXU04_RS04675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BXU04_RS04680	COG1217	gtp-binding protein TYPA
BXU04_RS04700	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BXU04_RS04830	COG3039	Transposase
BXU04_RS04850	COG0584	glycerophosphoryl diester phosphodiesterase
BXU04_RS04875	COG0473	3-isopropylmalate dehydrogenase activity
BXU04_RS04925	COG0544	peptidyl-prolyl cis-trans isomerase activity
BXU04_RS04965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BXU04_RS04990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BXU04_RS05000	COG0631	protein serine/threonine phosphatase activity
BXU04_RS05070	COG0582	viral genome integration into host DNA
BXU04_RS05080	COG0859	PFAM glycosyl transferase family 9
BXU04_RS05085	COG3642	lipopolysaccharide core region biosynthetic process
BXU04_RS05090	COG1234	tRNA 3'-trailer cleavage
BXU04_RS05095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BXU04_RS05105	COG0315	cyclic pyranopterin monophosphate synthase activity
BXU04_RS05110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BXU04_RS05115	COG0314	molybdopterin synthase activity
BXU04_RS05145	COG0537	adenosine 5'-monophosphoramidase activity
BXU04_RS05165	COG0714	Associated with various cellular activities
BXU04_RS05185	COG0242	peptide deformylase activity
BXU04_RS05230	COG3039	Transposase
BXU04_RS05255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BXU04_RS05260	COG0726	polysaccharide deacetylase
BXU04_RS05310	COG2211	Major facilitator Superfamily
BXU04_RS05320	COG1609	Transcriptional regulator
BXU04_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS05330	COG2851	Citrate transporter
BXU04_RS05345	COG0642	Histidine kinase
BXU04_RS05355	COG2197	response regulator
BXU04_RS05375	COG0583	DNA-binding transcription factor activity
BXU04_RS05390	COG4191	Histidine kinase
BXU04_RS05410	COG0280	phosphate acetyltransferase
BXU04_RS05410	COG0281	malic enzyme
BXU04_RS05435	COG0352	thiamine-phosphate diphosphorylase activity
BXU04_RS05440	COG1773	rubredoxin
BXU04_RS05445	COG2912	Transglutaminase-like superfamily
BXU04_RS05465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BXU04_RS05490	COG0006	proline dipeptidase activity
BXU04_RS05530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BXU04_RS05545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BXU04_RS05550	COG1561	YicC-like family, N-terminal region
BXU04_RS05575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BXU04_RS05585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BXU04_RS05615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BXU04_RS05665	COG0714	Associated with various cellular activities
BXU04_RS05685	COG2304	oxidoreductase activity
BXU04_RS05705	COG1301	dicarboxylic acid transport
BXU04_RS05710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BXU04_RS05720	COG0739	heme binding
BXU04_RS05725	COG1376	ErfK ybiS ycfS ynhG family protein
BXU04_RS05750	COG1022	Amp-dependent synthetase and ligase
BXU04_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS05775	COG0642	Histidine kinase
BXU04_RS05795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BXU04_RS05800	COG4149	molybdate abc transporter
BXU04_RS05805	COG0725	ABC transporter, periplasmic molybdate-binding protein
BXU04_RS05810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BXU04_RS05810	COG3453	Protein conserved in bacteria
BXU04_RS05840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BXU04_RS05860	COG2205	protein histidine kinase activity
BXU04_RS05865	COG0745	RESPONSE REGULATOR receiver
BXU04_RS05910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BXU04_RS05915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BXU04_RS05960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BXU04_RS06010	COG2201	protein-glutamate methylesterase activity
BXU04_RS06040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BXU04_RS06050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BXU04_RS06055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BXU04_RS06070	COG1842	Phage shock protein A
BXU04_RS06095	COG0754	glutathionylspermidine amidase activity
BXU04_RS06155	COG0531	amino acid
BXU04_RS06160	COG2197	response regulator
BXU04_RS06175	COG1113	amino acid transport
BXU04_RS06190	COG1271	oxidase subunit
BXU04_RS06195	COG1294	oxidase, subunit
BXU04_RS06205	COG2239	Acts as a magnesium transporter
BXU04_RS06210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BXU04_RS06215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BXU04_RS06230	COG1660	Displays ATPase and GTPase activities
BXU04_RS06235	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BXU04_RS06240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BXU04_RS06255	COG1137	ATPase activity
BXU04_RS06260	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BXU04_RS06270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BXU04_RS06280	COG0271	Belongs to the BolA IbaG family
BXU04_RS06285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BXU04_RS06305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BXU04_RS06320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BXU04_RS06330	COG0628	permease
BXU04_RS06340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BXU04_RS06345	COG3178	'Phosphotransferase
BXU04_RS06360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BXU04_RS06365	COG1555	photosystem II stabilization
BXU04_RS06405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BXU04_RS06415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BXU04_RS06435	COG0228	four-way junction DNA binding
BXU04_RS06440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BXU04_RS06445	COG0336	Belongs to the RNA methyltransferase TrmD family
BXU04_RS06460	COG0534	Mate efflux family protein
BXU04_RS06495	COG0542	response to heat
BXU04_RS06530	COG4206	TonB-dependent receptor
BXU04_RS06595	COG0019	diaminopimelate decarboxylase activity
BXU04_RS06610	COG4264	IucA IucC family
BXU04_RS06620	COG4772	TonB-dependent receptor
BXU04_RS06635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BXU04_RS06635	COG4651	solute:proton antiporter activity
BXU04_RS06670	COG0488	(ABC) transporter
BXU04_RS06695	COG0657	acetylesterase activity
BXU04_RS06695	COG2755	lipolytic protein G-D-S-L family
BXU04_RS06725	COG2207	Transcriptional regulator
BXU04_RS06730	COG0326	Molecular chaperone. Has ATPase activity
BXU04_RS06755	COG3328	transposase activity
BXU04_RS06760	COG0174	glutamine synthetase
BXU04_RS06765	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BXU04_RS06775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BXU04_RS06790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BXU04_RS06825	COG2146	nitrite reductase [NAD(P)H] activity
BXU04_RS06840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BXU04_RS06845	COG0719	Fe-S assembly protein
BXU04_RS06850	COG0396	ATPase activity
BXU04_RS06855	COG0719	Fe-S assembly protein
BXU04_RS06860	COG1959	2 iron, 2 sulfur cluster binding
BXU04_RS06930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BXU04_RS06955	COG0519	Catalyzes the synthesis of GMP from XMP
BXU04_RS06965	COG1678	Uncharacterized ACR, COG1678
BXU04_RS06970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BXU04_RS06985	COG1764	response to oxidative stress
BXU04_RS06995	COG0384	phenazine biosynthesis protein PhzF
BXU04_RS07005	COG0527	aspartate kinase activity
BXU04_RS07030	COG0142	geranyltranstransferase activity
BXU04_RS07035	COG0629	single-stranded DNA binding
BXU04_RS07040	COG2203	Gaf domain
BXU04_RS07040	COG3706	GGDEF domain
BXU04_RS07040	COG4251	negative regulation of phosphorylation
BXU04_RS07040	COG5001	Diguanylate cyclase
BXU04_RS07075	COG2879	small protein
BXU04_RS07080	COG1966	Carbon starvation protein
BXU04_RS07085	COG1741	Belongs to the pirin family
BXU04_RS07185	COG1741	Belongs to the pirin family
BXU04_RS07195	COG1515	deoxyribonuclease V activity
BXU04_RS07215	COG3590	peptidase
BXU04_RS07230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BXU04_RS07235	COG2199	diguanylate cyclase activity
BXU04_RS07235	COG2200	EAL domain
BXU04_RS07235	COG2202	Pas domain
BXU04_RS07240	COG0835	chemotaxis
BXU04_RS07245	COG0840	transmembrane signaling receptor activity
BXU04_RS07250	COG2198	Histidine kinase
BXU04_RS07250	COG0643	Histidine kinase
BXU04_RS07265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BXU04_RS07275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BXU04_RS07360	COG3039	Transposase
BXU04_RS07375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BXU04_RS07380	COG0735	belongs to the Fur family
BXU04_RS07440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BXU04_RS07445	COG0084	hydrolase, TatD family'
BXU04_RS07460	COG1960	acyl-CoA dehydrogenase activity
BXU04_RS07475	COG0367	asparagine synthase
BXU04_RS07485	COG0305	Participates in initiation and elongation during chromosome replication
BXU04_RS07490	COG0415	Belongs to the DNA photolyase family
BXU04_RS07605	COG5002	protein histidine kinase activity
BXU04_RS07605	COG5001	Diguanylate cyclase
BXU04_RS07610	COG1187	pseudouridine synthase activity
BXU04_RS07630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BXU04_RS07640	COG0475	glutathione-regulated potassium exporter activity
BXU04_RS07645	COG5002	protein histidine kinase activity
BXU04_RS07645	COG5000	phosphorelay sensor kinase activity
BXU04_RS07650	COG0745	RESPONSE REGULATOR receiver
BXU04_RS07680	COG1132	(ABC) transporter
BXU04_RS07710	COG3039	Transposase
BXU04_RS07740	COG3039	Transposase
BXU04_RS07770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BXU04_RS07780	COG4969	Belongs to the N-Me-Phe pilin family
BXU04_RS07785	COG2194	sulfuric ester hydrolase activity
BXU04_RS07810	COG2184	nucleotidyltransferase activity
BXU04_RS07835	COG0045	succinate-CoA ligase (ADP-forming) activity
BXU04_RS07840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BXU04_RS07855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BXU04_RS07855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BXU04_RS07860	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BXU04_RS07865	COG0564	pseudouridine synthase activity
BXU04_RS07890	COG3387	PFAM Glycoside hydrolase 15-related
BXU04_RS07895	COG1877	trehalose-phosphatase activity
BXU04_RS07930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BXU04_RS07955	COG1946	Acyl-CoA thioesterase
BXU04_RS07970	COG0824	Thioesterase
BXU04_RS07975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BXU04_RS07985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BXU04_RS07990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BXU04_RS07995	COG0268	Binds directly to 16S ribosomal RNA
BXU04_RS08000	COG0728	peptidoglycan biosynthetic process
BXU04_RS08005	COG0196	riboflavin kinase activity
BXU04_RS08015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BXU04_RS08020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BXU04_RS08035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BXU04_RS08040	COG1845	cytochrome c oxidase, subunit III
BXU04_RS08045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BXU04_RS08065	COG3209	COG3209 Rhs family protein
BXU04_RS08065	COG3209	COG3209 Rhs family protein
BXU04_RS08170	COG0632	four-way junction helicase activity
BXU04_RS08180	COG2255	four-way junction helicase activity
BXU04_RS08185	COG0824	Thioesterase
BXU04_RS08195	COG0848	biopolymer transport protein
BXU04_RS08210	COG2885	chlorophyll binding
BXU04_RS08220	COG0602	queuosine metabolic process
BXU04_RS08225	COG1187	pseudouridine synthase activity
BXU04_RS08280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BXU04_RS08305	COG0514	ATP-dependent DNA helicase (RecQ)
BXU04_RS08310	COG0783	Belongs to the Dps family
BXU04_RS08315	COG1643	Atp-dependent helicase
BXU04_RS08370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BXU04_RS08380	COG1215	transferase activity, transferring glycosyl groups
BXU04_RS08385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BXU04_RS08395	COG1199	ATP-dependent helicase activity
BXU04_RS08405	COG1397	ADP-ribosylglycohydrolase
BXU04_RS08415	COG0189	ligase activity
BXU04_RS08430	COG0835	chemotaxis
BXU04_RS08435	COG0840	transmembrane signaling receptor activity
BXU04_RS08440	COG0643	Histidine kinase
BXU04_RS08440	COG0784	Response regulator, receiver
BXU04_RS08440	COG2198	Histidine kinase
BXU04_RS08465	COG2304	oxidoreductase activity
BXU04_RS08470	COG2304	oxidoreductase activity
BXU04_RS08480	COG1446	asparaginase
BXU04_RS08485	COG3142	Participates in the control of copper homeostasis
BXU04_RS08535	COG3537	Alpha-1,2-mannosidase
BXU04_RS08600	COG1472	Belongs to the glycosyl hydrolase 3 family
BXU04_RS08610	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BXU04_RS08620	COG1388	LysM domain
BXU04_RS08620	COG3858	chitin binding
BXU04_RS08635	COG0837	glucose binding
BXU04_RS08640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BXU04_RS08650	COG0494	nUDIX hydrolase
BXU04_RS08660	COG3956	TIGRFAM MazG family protein
BXU04_RS08675	COG0330	HflC and HflK could
BXU04_RS08690	COG0509	glycine decarboxylation via glycine cleavage system
BXU04_RS08725	COG1960	acyl-CoA dehydrogenase activity
BXU04_RS08735	COG1309	transcriptional regulator
BXU04_RS08740	COG4771	TonB-dependent receptor
BXU04_RS08750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BXU04_RS08760	COG0463	Glycosyl transferase, family 2
BXU04_RS08785	COG1272	protein, Hemolysin III
BXU04_RS08795	COG0739	heme binding
BXU04_RS08800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BXU04_RS08805	COG0626	cystathionine gamma-synthase activity
BXU04_RS08815	COG1760	l-serine dehydratase
BXU04_RS08830	COG2353	YceI-like domain
BXU04_RS08840	COG2353	YceI-like domain
BXU04_RS08910	COG1960	acyl-CoA dehydrogenase activity
BXU04_RS08915	COG1024	Enoyl-CoA hydratase
BXU04_RS08935	COG1250	3-hydroxyacyl-CoA dehydrogenase
BXU04_RS08935	COG1024	Enoyl-CoA hydratase
BXU04_RS08950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BXU04_RS08980	COG1381	Involved in DNA repair and RecF pathway recombination
BXU04_RS08995	COG2954	triphosphatase activity
BXU04_RS09010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BXU04_RS09015	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BXU04_RS09020	COG3046	protein related to deoxyribodipyrimidine photolyase
BXU04_RS09030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BXU04_RS09035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BXU04_RS09040	COG1278	Cold shock
BXU04_RS09070	COG1201	RNA secondary structure unwinding
BXU04_RS09075	COG1793	dna ligase
BXU04_RS09085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BXU04_RS09085	COG1793	dna ligase
BXU04_RS09115	COG0183	Belongs to the thiolase family
BXU04_RS09155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BXU04_RS09180	COG3039	Transposase
BXU04_RS09195	COG1047	Peptidyl-prolyl cis-trans
BXU04_RS09210	COG2824	Alkylphosphonate utilization operon protein PhnA
BXU04_RS09220	COG1902	pentaerythritol trinitrate reductase activity
BXU04_RS09225	COG2814	Major facilitator Superfamily
BXU04_RS09270	COG0392	lysyltransferase activity
BXU04_RS09270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BXU04_RS09280	COG0251	oxidation-reduction process
BXU04_RS09285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BXU04_RS09300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BXU04_RS09325	COG1595	DNA-templated transcription, initiation
BXU04_RS09340	COG2878	Part of a membrane complex involved in electron transport
BXU04_RS09350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BXU04_RS09350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BXU04_RS09370	COG0833	amino acid
BXU04_RS09375	COG2040	homocysteine
BXU04_RS09390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BXU04_RS09425	COG2895	sulfate adenylyltransferase (ATP) activity
BXU04_RS09425	COG0529	Catalyzes the synthesis of activated sulfate
BXU04_RS09470	COG1981	membrane
BXU04_RS09495	COG1131	(ABC) transporter
BXU04_RS09500	COG4771	TonB-dependent receptor
BXU04_RS09510	COG0825	malonyl-CoA metabolic process
BXU04_RS09530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BXU04_RS09535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BXU04_RS09555	COG0750	zinc metalloprotease
BXU04_RS09565	COG0575	Belongs to the CDS family
BXU04_RS09575	COG0233	cytoplasmic translational termination
BXU04_RS09590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BXU04_RS09650	COG1393	Belongs to the ArsC family
BXU04_RS09665	COG0367	asparagine synthase
BXU04_RS09675	COG4774	siderophore transport
BXU04_RS09710	COG1566	PFAM secretion protein HlyD family protein
BXU04_RS09715	COG2814	Major facilitator Superfamily
BXU04_RS09760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BXU04_RS09770	COG1960	acyl-CoA dehydrogenase activity
BXU04_RS09795	COG2914	Belongs to the UPF0125 (RnfH) family
BXU04_RS09800	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BXU04_RS09810	COG0497	DNA recombination
BXU04_RS09820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BXU04_RS09825	COG0443	Heat shock 70 kDa protein
BXU04_RS09830	COG0484	heat shock protein binding
BXU04_RS09835	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BXU04_RS09840	COG0287	Prephenate dehydrogenase
BXU04_RS09840	COG1605	Chorismate mutase
BXU04_RS09865	COG1132	(ABC) transporter
BXU04_RS09900	COG2850	peptidyl-arginine hydroxylation
BXU04_RS09975	COG1131	(ABC) transporter
BXU04_RS09980	COG1725	Transcriptional regulator
BXU04_RS09990	COG0386	Belongs to the glutathione peroxidase family
BXU04_RS10005	COG2900	Belongs to the SlyX family
BXU04_RS10020	COG1609	Transcriptional regulator
BXU04_RS10030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BXU04_RS10040	COG1410	methionine synthase
BXU04_RS10040	COG0646	methionine synthase
BXU04_RS10045	COG1410	methionine synthase
BXU04_RS10045	COG0646	methionine synthase
BXU04_RS10050	COG2226	methyltransferase
BXU04_RS10055	COG1960	acyl-CoA dehydrogenase activity
BXU04_RS10080	COG0557	exoribonuclease II activity
BXU04_RS10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BXU04_RS10110	COG3039	Transposase
BXU04_RS10130	COG3328	transposase activity
BXU04_RS10155	COG3039	Transposase
BXU04_RS10160	COG3039	Transposase
BXU04_RS10210	COG3039	Transposase
BXU04_RS10260	COG3039	Transposase
BXU04_RS10270	COG0583	DNA-binding transcription factor activity
BXU04_RS10320	COG2201	protein-glutamate methylesterase activity
BXU04_RS10360	COG0531	amino acid
BXU04_RS10365	COG0531	amino acid
BXU04_RS10375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BXU04_RS10380	COG0277	FAD linked oxidase domain protein
BXU04_RS10445	COG0436	Aminotransferase
BXU04_RS10470	COG1187	pseudouridine synthase activity
BXU04_RS10475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BXU04_RS10480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BXU04_RS10485	COG2350	Protein conserved in bacteria
BXU04_RS10515	COG1175	transmembrane transport
BXU04_RS10520	COG0395	ABC-type sugar transport system, permease component
BXU04_RS10545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BXU04_RS10555	COG2957	Belongs to the agmatine deiminase family
BXU04_RS10570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BXU04_RS10575	COG0539	negative regulation of cytoplasmic translation
BXU04_RS10580	COG0776	regulation of translation
BXU04_RS10590	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BXU04_RS10595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BXU04_RS10605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BXU04_RS10625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BXU04_RS10640	COG3002	Belongs to the UPF0753 family
BXU04_RS10645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BXU04_RS10650	COG0583	DNA-binding transcription factor activity
BXU04_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS10680	COG0583	DNA-binding transcription factor activity
BXU04_RS10700	COG1914	H( )-stimulated, divalent metal cation uptake system
BXU04_RS10720	COG0668	transmembrane transport
BXU04_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS10775	COG1183	phosphatidylcholine synthase activity
BXU04_RS10785	COG3243	poly(R)-hydroxyalkanoic acid synthase
BXU04_RS10800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BXU04_RS10800	COG0723	plastoquinol--plastocyanin reductase activity
BXU04_RS10810	COG2183	response to ionizing radiation
BXU04_RS10825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BXU04_RS10840	COG0671	phosphoesterase, PA-phosphatase related
BXU04_RS10870	COG0697	spore germination
BXU04_RS10875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BXU04_RS10895	COG1012	belongs to the aldehyde dehydrogenase family
BXU04_RS10930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BXU04_RS10945	COG0124	histidyl-tRNA synthetase
BXU04_RS10965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BXU04_RS10980	COG0131	Imidazoleglycerol-phosphate dehydratase
BXU04_RS10980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BXU04_RS10990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BXU04_RS11000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BXU04_RS11000	COG0140	phosphoribosyl-ATP diphosphatase activity
BXU04_RS11170	COG3039	Transposase
BXU04_RS11250	COG3039	Transposase
BXU04_RS11270	COG3328	transposase activity
BXU04_RS11305	COG0322	excinuclease ABC activity
BXU04_RS11315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BXU04_RS11325	COG1663	tetraacyldisaccharide 4'-kinase activity
BXU04_RS11340	COG0811	peptide transport
BXU04_RS11365	COG4591	ABC-type transport system involved in lipoprotein release permease component
BXU04_RS11380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BXU04_RS11395	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BXU04_RS11410	COG0354	folic acid binding
BXU04_RS11425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BXU04_RS11435	COG0363	glucosamine-6-phosphate deaminase activity
BXU04_RS11440	COG0129	dihydroxy-acid dehydratase activity
BXU04_RS11445	COG0800	Aldolase
BXU04_RS11475	COG0784	Response regulator, receiver
BXU04_RS11475	COG2205	protein histidine kinase activity
BXU04_RS11475	COG5002	protein histidine kinase activity
BXU04_RS11555	COG0386	Belongs to the glutathione peroxidase family
BXU04_RS11640	COG2203	Gaf domain
BXU04_RS11640	COG3706	GGDEF domain
BXU04_RS11640	COG4251	negative regulation of phosphorylation
BXU04_RS11640	COG5001	Diguanylate cyclase
BXU04_RS11655	COG1472	Belongs to the glycosyl hydrolase 3 family
BXU04_RS11685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BXU04_RS11700	COG0617	tRNA 3'-terminal CCA addition
BXU04_RS11710	COG1469	GTP cyclohydrolase I activity
BXU04_RS11715	COG0860	N-Acetylmuramoyl-L-alanine amidase
BXU04_RS11760	COG4566	intracellular signal transduction
BXU04_RS11790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BXU04_RS11795	COG0077	Prephenate dehydratase
BXU04_RS11795	COG1605	Chorismate mutase
BXU04_RS11805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BXU04_RS11845	COG1228	amidohydrolase
BXU04_RS11850	COG2986	histidine ammonia-lyase
BXU04_RS11860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BXU04_RS11885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BXU04_RS11900	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BXU04_RS11920	COG3115	cell septum assembly
BXU04_RS11930	COG0359	binds to the 23S rRNA
BXU04_RS11940	COG0360	Binds together with S18 to 16S ribosomal RNA
BXU04_RS11945	COG0316	Belongs to the HesB IscA family
BXU04_RS11975	COG0288	reversible hydration of carbon dioxide
BXU04_RS12000	COG2925	Exonuclease
BXU04_RS12010	COG0667	Aldo Keto reductase
BXU04_RS12035	COG0116	Belongs to the methyltransferase superfamily
BXU04_RS12035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BXU04_RS12080	COG0494	nUDIX hydrolase
BXU04_RS12095	COG1024	Enoyl-CoA hydratase
BXU04_RS12105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BXU04_RS12125	COG3039	Transposase
BXU04_RS12165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BXU04_RS12170	COG0573	inorganic phosphate transmembrane transporter activity
BXU04_RS12185	COG0704	Plays a role in the regulation of phosphate uptake
BXU04_RS12195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BXU04_RS12210	COG3328	transposase activity
BXU04_RS12230	COG3039	Transposase
BXU04_RS12240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BXU04_RS12245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BXU04_RS12250	COG1862	Preprotein translocase
BXU04_RS12255	COG0343	queuine tRNA-ribosyltransferase activity
BXU04_RS12330	COG0405	Gamma-glutamyltransferase
BXU04_RS12335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BXU04_RS12345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BXU04_RS12350	COG0742	ribosomal rna small subunit methyltransferase
BXU04_RS12370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BXU04_RS12405	COG3039	Transposase
BXU04_RS12435	COG0303	'Molybdopterin
BXU04_RS12445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BXU04_RS12455	COG1426	Protein conserved in bacteria
BXU04_RS12465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BXU04_RS12480	COG1024	Enoyl-CoA hydratase
BXU04_RS12480	COG1250	3-hydroxyacyl-CoA dehydrogenase
BXU04_RS12485	COG0183	Belongs to the thiolase family
BXU04_RS12490	COG0038	chloride channel
BXU04_RS12510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BXU04_RS12530	COG1674	ftsk spoiiie
BXU04_RS12535	COG0492	ferredoxin-NADP+ reductase activity
BXU04_RS12570	COG0542	response to heat
BXU04_RS12585	COG0482	sulfurtransferase activity
BXU04_RS12610	COG5001	Diguanylate cyclase
BXU04_RS12615	COG4585	Histidine kinase
BXU04_RS12625	COG5002	protein histidine kinase activity
BXU04_RS12645	COG0835	chemotaxis
BXU04_RS12645	COG0784	Response regulator, receiver
BXU04_RS12655	COG1558	bacterial-type flagellum-dependent cell motility
BXU04_RS12660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BXU04_RS12670	COG4787	bacterial-type flagellum-dependent cell motility
BXU04_RS12705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BXU04_RS12710	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BXU04_RS12745	COG2201	protein-glutamate methylesterase activity
BXU04_RS12765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BXU04_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS12805	COG1677	Flagellar hook-basal body complex protein FliE
BXU04_RS12855	COG3190	flagellar
BXU04_RS12870	COG1684	flagellar biosynthetic protein fliR
BXU04_RS12925	COG2198	Histidine kinase
BXU04_RS12925	COG0784	Response regulator, receiver
BXU04_RS12925	COG0643	Histidine kinase
BXU04_RS12950	COG3039	Transposase
BXU04_RS12960	COG3209	COG3209 Rhs family protein
BXU04_RS12970	COG3039	Transposase
BXU04_RS12980	COG3039	Transposase
BXU04_RS13065	COG3039	Transposase
BXU04_RS13075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BXU04_RS13080	COG4988	ABC transporter
BXU04_RS13115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BXU04_RS13135	COG0165	Argininosuccinate lyase
BXU04_RS13150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BXU04_RS13155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BXU04_RS13165	COG0137	argininosuccinate synthase activity
BXU04_RS13170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BXU04_RS13185	COG2166	iron-sulfur cluster assembly
BXU04_RS13210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BXU04_RS13245	COG3039	Transposase
BXU04_RS13255	COG4677	pectinesterase activity
BXU04_RS13280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BXU04_RS13285	COG0402	S-adenosylhomocysteine deaminase activity
BXU04_RS13300	COG1509	lysine 2,3-aminomutase activity
BXU04_RS13305	COG3300	MHYT domain
BXU04_RS13305	COG5001	Diguanylate cyclase
BXU04_RS13320	COG0483	inositol monophosphate 1-phosphatase activity
BXU04_RS13325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BXU04_RS13345	COG0488	(ABC) transporter
BXU04_RS13350	COG0513	Belongs to the DEAD box helicase family
BXU04_RS13370	COG0625	glutathione transferase activity
BXU04_RS13380	COG1671	Belongs to the UPF0178 family
BXU04_RS13385	COG4681	YaeQ
BXU04_RS13390	COG2081	HI0933 family
BXU04_RS13410	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS13430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BXU04_RS13435	COG0860	N-Acetylmuramoyl-L-alanine amidase
BXU04_RS13440	COG0802	atpase or kinase
BXU04_RS13445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BXU04_RS13445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BXU04_RS13450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BXU04_RS13475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BXU04_RS13540	COG3328	transposase activity
BXU04_RS13550	COG2094	Belongs to the DNA glycosylase MPG family
BXU04_RS13575	COG2969	positive regulation of protein catabolic process
BXU04_RS13580	COG0625	glutathione transferase activity
BXU04_RS13585	COG2857	Cytochrome c1
BXU04_RS13590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BXU04_RS13595	COG0723	plastoquinol--plastocyanin reductase activity
BXU04_RS13600	COG0741	lytic transglycosylase activity
BXU04_RS13625	COG1702	phosphate starvation-inducible protein PhoH
BXU04_RS13645	COG4535	Mg2 and Co2 transporter CorC
BXU04_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
BXU04_RS13680	COG3842	ATPase activity
BXU04_RS13715	COG0174	glutamine synthetase
BXU04_RS13720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BXU04_RS13730	COG0477	Major facilitator Superfamily
BXU04_RS13740	COG0243	molybdopterin cofactor binding
BXU04_RS13750	COG2223	nitrite transmembrane transporter activity
BXU04_RS13755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BXU04_RS13760	COG1121	(ABC) transporter
BXU04_RS13770	COG2733	membrane
BXU04_RS13775	COG0784	Response regulator, receiver
BXU04_RS13775	COG5002	protein histidine kinase activity
BXU04_RS13775	COG2205	protein histidine kinase activity
BXU04_RS13785	COG3039	Transposase
BXU04_RS13790	COG2902	Dehydrogenase
BXU04_RS13800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BXU04_RS13805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BXU04_RS13825	COG1609	Transcriptional regulator
BXU04_RS13830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BXU04_RS13830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BXU04_RS13835	COG1105	Belongs to the carbohydrate kinase PfkB family
BXU04_RS13840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BXU04_RS13840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BXU04_RS13850	COG3039	Transposase
BXU04_RS13920	COG3409	Peptidoglycan-binding domain 1 protein
BXU04_RS13920	COG3501	Rhs element vgr protein
BXU04_RS13940	COG3409	Peptidoglycan-binding domain 1 protein
BXU04_RS13940	COG3501	Rhs element vgr protein
BXU04_RS13975	COG4771	TonB-dependent receptor
BXU04_RS13985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BXU04_RS14005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BXU04_RS14010	COG1360	Flagellar Motor Protein
BXU04_RS14020	COG0835	chemotaxis
BXU04_RS14030	COG0745	RESPONSE REGULATOR receiver
BXU04_RS14060	COG0840	transmembrane signaling receptor activity
BXU04_RS14070	COG0840	transmembrane signaling receptor activity
BXU04_RS14080	COG0840	transmembrane signaling receptor activity
BXU04_RS14085	COG0840	transmembrane signaling receptor activity
BXU04_RS14090	COG0840	transmembrane signaling receptor activity
BXU04_RS14095	COG0840	transmembrane signaling receptor activity
BXU04_RS14110	COG0835	chemotaxis
BXU04_RS14130	COG0840	transmembrane signaling receptor activity
BXU04_RS14160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BXU04_RS14190	COG0318	PFAM AMP-dependent synthetase and ligase
BXU04_RS14195	COG1024	Enoyl-CoA hydratase
BXU04_RS14200	COG2198	Histidine kinase
BXU04_RS14200	COG2205	protein histidine kinase activity
BXU04_RS14200	COG0784	Response regulator, receiver
BXU04_RS14260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BXU04_RS14270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BXU04_RS14275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BXU04_RS14285	COG0505	Belongs to the CarA family
BXU04_RS14290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BXU04_RS14300	COG2258	MOSC domain
BXU04_RS14305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BXU04_RS14350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BXU04_RS14370	COG0477	Major facilitator Superfamily
BXU04_RS14380	COG1070	Carbohydrate kinase
BXU04_RS14390	COG1501	Belongs to the glycosyl hydrolase 31 family
BXU04_RS14405	COG0800	Aldolase
BXU04_RS14410	COG4948	Mandelate Racemase Muconate Lactonizing
BXU04_RS14420	COG3734	2-keto-3-deoxy-galactonokinase
BXU04_RS14425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BXU04_RS14435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BXU04_RS14450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BXU04_RS14455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BXU04_RS14465	COG0351	phosphomethylpyrimidine kinase
BXU04_RS14490	COG0583	DNA-binding transcription factor activity
BXU04_RS14495	COG1741	Belongs to the pirin family
BXU04_RS14510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BXU04_RS14515	COG0305	Participates in initiation and elongation during chromosome replication
BXU04_RS14535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BXU04_RS14540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BXU04_RS14545	COG2137	regulation of response to DNA damage stimulus
BXU04_RS14550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BXU04_RS14565	COG1546	Belongs to the CinA family
BXU04_RS14570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BXU04_RS14585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BXU04_RS14595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BXU04_RS14600	COG1534	Rna-binding protein
BXU04_RS14615	COG1238	metal cluster binding
BXU04_RS14620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BXU04_RS14625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BXU04_RS14630	COG2840	Smr protein MutS2
BXU04_RS14640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BXU04_RS14655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BXU04_RS14660	COG0148	phosphopyruvate hydratase activity
BXU04_RS14670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BXU04_RS14675	COG0504	CTP synthase activity
BXU04_RS14700	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BXU04_RS14705	COG0306	phosphate transporter
BXU04_RS14715	COG1253	flavin adenine dinucleotide binding
BXU04_RS14730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BXU04_RS14740	COG0477	Major facilitator Superfamily
BXU04_RS14750	COG1132	(ABC) transporter
BXU04_RS14755	COG1136	(ABC) transporter
BXU04_RS14775	COG0438	transferase activity, transferring glycosyl groups
BXU04_RS14785	COG2264	protein methyltransferase activity
BXU04_RS14815	COG2244	polysaccharide biosynthetic process
BXU04_RS14865	COG1595	DNA-templated transcription, initiation
BXU04_RS14880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BXU04_RS14900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BXU04_RS14945	COG2201	protein-glutamate methylesterase activity
BXU04_RS14970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BXU04_RS15025	COG1858	cytochrome C peroxidase
BXU04_RS15060	COG0515	serine threonine protein kinase
BXU04_RS15065	COG0631	protein serine/threonine phosphatase activity
BXU04_RS15170	COG3039	Transposase
BXU04_RS15185	COG3039	Transposase
BXU04_RS15230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BXU04_RS15230	COG0316	Belongs to the HesB IscA family
BXU04_RS15235	COG2154	pterin-4-alpha-carbinolamine dehydratase
BXU04_RS15260	COG1530	ribonuclease E activity
BXU04_RS15275	COG1054	Belongs to the UPF0176 family
BXU04_RS15280	COG3039	Transposase
BXU04_RS15300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BXU04_RS15335	COG3039	Transposase
BXU04_RS15340	COG3039	Transposase
BXU04_RS15375	COG1648	precorrin-2 dehydrogenase activity
BXU04_RS15375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BXU04_RS15400	COG0746	molybdenum cofactor guanylyltransferase activity
BXU04_RS15490	COG4206	TonB-dependent receptor
BXU04_RS15525	COG0531	amino acid
BXU04_RS15540	COG0006	proline dipeptidase activity
BXU04_RS15550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BXU04_RS15565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BXU04_RS15570	COG3938	Belongs to the proline racemase family
BXU04_RS15580	COG0552	protein localization to endoplasmic reticulum
BXU04_RS15600	COG0784	Response regulator, receiver
BXU04_RS15600	COG4191	Histidine kinase
BXU04_RS15680	COG3040	lipid binding
BXU04_RS15720	COG0438	transferase activity, transferring glycosyl groups
BXU04_RS15730	COG0438	transferase activity, transferring glycosyl groups
BXU04_RS15735	COG0438	transferase activity, transferring glycosyl groups
BXU04_RS15805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BXU04_RS15840	COG0556	nucleotide-excision repair
BXU04_RS15845	COG4969	Belongs to the N-Me-Phe pilin family
BXU04_RS15885	COG1611	Belongs to the LOG family
BXU04_RS15900	COG2095	MarC family integral membrane protein
BXU04_RS15910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BXU04_RS15945	COG1185	polyribonucleotide nucleotidyltransferase activity
BXU04_RS15950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BXU04_RS15970	COG0195	Participates in both transcription termination and antitermination
BXU04_RS15975	COG0779	Required for maturation of 30S ribosomal subunits
BXU04_RS15985	COG1007	ATP synthesis coupled electron transport
BXU04_RS16015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BXU04_RS16020	COG1034	ATP synthesis coupled electron transport
BXU04_RS16025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BXU04_RS16030	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BXU04_RS16035	COG0649	NAD binding
BXU04_RS16040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BXU04_RS16050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BXU04_RS16065	COG0149	triose-phosphate isomerase activity
BXU04_RS16115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BXU04_RS16120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BXU04_RS16145	COG0135	phosphoribosylanthranilate isomerase activity
BXU04_RS16150	COG0101	tRNA pseudouridine synthase activity
BXU04_RS16170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BXU04_RS16175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BXU04_RS16180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BXU04_RS16185	COG2890	protein-(glutamine-N5) methyltransferase activity
BXU04_RS16220	COG3039	Transposase
BXU04_RS16230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BXU04_RS16260	COG0717	Belongs to the dCTP deaminase family
BXU04_RS16265	COG0489	protein tyrosine kinase activity
BXU04_RS16305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BXU04_RS16310	COG2311	Membrane
BXU04_RS16315	COG1047	Peptidyl-prolyl cis-trans
BXU04_RS16320	COG0791	NLP P60 protein
BXU04_RS16325	COG0791	NLP P60 protein
BXU04_RS16345	COG1785	Belongs to the alkaline phosphatase family
BXU04_RS16350	COG0037	tRNA processing
BXU04_RS16355	COG1722	exodeoxyribonuclease VII activity
BXU04_RS16360	COG0142	geranyltranstransferase activity
BXU04_RS16385	COG0312	modulator of DNA gyrase
BXU04_RS16395	COG0312	modulator of DNA gyrase
BXU04_RS16405	COG3164	Protein of unknown function
BXU04_RS16420	COG2968	Membrane
BXU04_RS16445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BXU04_RS16465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BXU04_RS16490	COG3118	belongs to the thioredoxin family
BXU04_RS16555	COG3039	Transposase
BXU04_RS16560	COG3039	Transposase
BXU04_RS16645	COG2022	thiamine diphosphate biosynthetic process
BXU04_RS16655	COG0471	metal ion transport
BXU04_RS16655	COG3273	potassium ion transport
BXU04_RS16685	COG1970	mechanosensitive ion channel activity
BXU04_RS16705	COG2272	Belongs to the type-B carboxylesterase lipase family
BXU04_RS16710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BXU04_RS16730	COG0308	aminopeptidase N
BXU04_RS16735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BXU04_RS16745	COG0529	Catalyzes the synthesis of activated sulfate
BXU04_RS16745	COG2895	sulfate adenylyltransferase (ATP) activity
BXU04_RS16750	COG0175	sulfate reduction
BXU04_RS16755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BXU04_RS16760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BXU04_RS16765	COG0175	sulfate reduction
BXU04_RS16835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BXU04_RS16840	COG3588	fructose-bisphosphate aldolase
BXU04_RS16845	COG0469	pyruvate kinase activity
BXU04_RS16855	COG0126	phosphoglycerate kinase activity
BXU04_RS16885	COG0753	catalase activity
BXU04_RS16905	COG3039	Transposase
BXU04_RS16925	COG2207	Transcriptional regulator
BXU04_RS16925	COG1917	Cupin 2, conserved barrel domain protein
BXU04_RS16955	COG0823	Involved in the tonB-independent uptake of proteins
BXU04_RS16955	COG1506	peptidase
BXU04_RS16975	COG3039	Transposase
BXU04_RS16980	COG1297	OPT oligopeptide transporter protein
BXU04_RS17070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BXU04_RS17085	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BXU04_RS17090	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BXU04_RS17095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BXU04_RS17115	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BXU04_RS17280	COG3179	chitinase
BXU04_RS17380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BXU04_RS17385	COG3039	Transposase
BXU04_RS17400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BXU04_RS17500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BXU04_RS17525	COG2197	response regulator
BXU04_RS17530	COG4585	Histidine kinase
BXU04_RS17545	COG2894	cell division
BXU04_RS17550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BXU04_RS17560	COG0642	Histidine kinase
BXU04_RS17565	COG0745	RESPONSE REGULATOR receiver
BXU04_RS17570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BXU04_RS17580	COG2194	sulfuric ester hydrolase activity
BXU04_RS17610	COG3551	Protein conserved in bacteria
BXU04_RS17670	COG0203	ribosomal protein L17
BXU04_RS17680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BXU04_RS17685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BXU04_RS17695	COG0201	protein transport
BXU04_RS17705	COG1841	ribosomal large subunit assembly
BXU04_RS17735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BXU04_RS17745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BXU04_RS17750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BXU04_RS17755	COG0255	Belongs to the universal ribosomal protein uL29 family
BXU04_RS17760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BXU04_RS17770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BXU04_RS17785	COG0089	rRNA binding
BXU04_RS17790	COG0088	Forms part of the polypeptide exit tunnel
BXU04_RS17795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BXU04_RS17800	COG0051	transcription antitermination factor activity, RNA binding
BXU04_RS17820	COG0049	tRNA binding
BXU04_RS17825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BXU04_RS17830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BXU04_RS17835	COG0085	RNA polymerase activity
BXU04_RS17840	COG0222	ribosome binding
BXU04_RS17845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BXU04_RS17855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BXU04_RS17860	COG0250	Participates in transcription elongation, termination and antitermination
BXU04_RS17865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BXU04_RS17895	COG0012	GTP binding
BXU04_RS17900	COG0193	aminoacyl-tRNA hydrolase activity
BXU04_RS17910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BXU04_RS17925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BXU04_RS17940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BXU04_RS17950	COG0521	Mo-molybdopterin cofactor biosynthetic process
BXU04_RS17970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BXU04_RS17975	COG1295	ribonuclease BN
BXU04_RS18005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BXU04_RS18015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BXU04_RS18040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BXU04_RS18065	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BXU04_RS18080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BXU04_RS18080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BXU04_RS18130	COG2890	protein-(glutamine-N5) methyltransferase activity
BXU04_RS18140	COG3634	alkyl hydroperoxide reductase activity
BXU04_RS18145	COG0583	DNA-binding transcription factor activity
BXU04_RS18150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BXU04_RS18155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BXU04_RS18215	COG4783	chaperone-mediated protein folding
BXU04_RS18230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BXU04_RS18240	COG0438	transferase activity, transferring glycosyl groups
BXU04_RS18245	COG0671	phosphoesterase, PA-phosphatase related
BXU04_RS18250	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BXU04_RS18270	COG2833	Protein of unknown function (DUF455)
BXU04_RS18290	COG0285	dihydrofolate synthase activity
BXU04_RS18300	COG0406	alpha-ribazole phosphatase activity
BXU04_RS18330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BXU04_RS18335	COG4208	sulfate ABC transporter
BXU04_RS18340	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BXU04_RS18345	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BXU04_RS18350	COG0156	8-amino-7-oxononanoate synthase activity
BXU04_RS18375	COG0604	alcohol dehydrogenase
BXU04_RS18380	COG1902	pentaerythritol trinitrate reductase activity
BXU04_RS18380	COG0446	pyridine nucleotide-disulphide oxidoreductase
BXU04_RS18510	COG3386	PFAM SMP-30 Gluconolaconase
BXU04_RS18530	COG1024	Enoyl-CoA hydratase
BXU04_RS18540	COG0318	PFAM AMP-dependent synthetase and ligase
BXU04_RS18545	COG0583	DNA-binding transcription factor activity
BXU04_RS18585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BXU04_RS18590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BXU04_RS18600	COG2096	Adenosyltransferase
BXU04_RS18605	COG0123	including yeast histone deacetylase and acetoin utilization protein
BXU04_RS18620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BXU04_RS18630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BXU04_RS18635	COG2967	ApaG domain
BXU04_RS18660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BXU04_RS18680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BXU04_RS18695	COG0642	Histidine kinase
BXU04_RS18710	COG4181	ATPase activity
BXU04_RS18720	COG2175	clavaminate synthase activity
BXU04_RS18770	COG0667	Aldo Keto reductase
BXU04_RS18780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BXU04_RS18785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BXU04_RS18795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BXU04_RS18810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BXU04_RS18855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BXU04_RS18860	COG2226	methyltransferase
BXU04_RS18905	COG0604	alcohol dehydrogenase
BXU04_RS18905	COG3321	synthase
BXU04_RS18905	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS18915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BXU04_RS18930	COG0494	nUDIX hydrolase
BXU04_RS18945	COG1388	LysM domain
BXU04_RS18945	COG4942	peptidase
BXU04_RS18955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BXU04_RS18970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BXU04_RS18975	COG1181	Belongs to the D-alanine--D-alanine ligase family
BXU04_RS18980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BXU04_RS19000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BXU04_RS19015	COG3116	cell division
BXU04_RS19020	COG0275	rRNA processing
BXU04_RS19055	COG0792	nuclease activity
BXU04_RS19060	COG1988	membrane-bound metal-dependent
BXU04_RS19065	COG0277	FAD linked oxidase domain protein
BXU04_RS19070	COG0745	RESPONSE REGULATOR receiver
BXU04_RS19075	COG2205	protein histidine kinase activity
BXU04_RS19085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BXU04_RS19090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BXU04_RS19110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BXU04_RS19115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BXU04_RS19120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BXU04_RS19140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BXU04_RS19140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BXU04_RS19160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BXU04_RS19180	COG0488	(ABC) transporter
BXU04_RS19205	COG3791	Glutathione-dependent formaldehyde-activating
BXU04_RS19230	COG2205	protein histidine kinase activity
BXU04_RS19285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BXU04_RS19320	COG3039	Transposase
BXU04_RS19325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BXU04_RS19335	COG3039	Transposase
BXU04_RS19385	COG3039	Transposase
BXU04_RS19430	COG1649	PFAM Uncharacterised BCR, COG1649
BXU04_RS19430	COG0726	polysaccharide deacetylase
BXU04_RS19435	COG1215	transferase activity, transferring glycosyl groups
BXU04_RS19445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BXU04_RS19450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BXU04_RS19455	COG1609	Transcriptional regulator
BXU04_RS19465	COG2188	Transcriptional regulator
BXU04_RS19480	COG3250	beta-galactosidase activity
BXU04_RS19520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BXU04_RS19525	COG4191	Histidine kinase
BXU04_RS19530	COG0784	Response regulator, receiver
BXU04_RS19535	COG4251	negative regulation of phosphorylation
BXU04_RS19540	COG2823	Periplasmic or secreted lipoprotein
BXU04_RS19545	COG0673	inositol 2-dehydrogenase activity
BXU04_RS19550	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BXU04_RS19585	COG1051	belongs to the nudix hydrolase family
BXU04_RS19585	COG1056	cytidyltransferase-related domain
BXU04_RS19610	COG2921	Belongs to the UPF0250 family
BXU04_RS19625	COG1686	Belongs to the peptidase S11 family
BXU04_RS19630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BXU04_RS19635	COG2951	lytic endotransglycosylase activity
BXU04_RS19680	COG0772	Belongs to the SEDS family
BXU04_RS19695	COG1792	Involved in formation and maintenance of cell shape
BXU04_RS19700	COG1077	Cell shape determining protein MreB Mrl
BXU04_RS19705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BXU04_RS19750	COG2199	diguanylate cyclase activity
BXU04_RS19755	COG0308	aminopeptidase N
BXU04_RS19785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BXU04_RS19815	COG0436	Aminotransferase
BXU04_RS19830	COG1505	serine-type exopeptidase activity
BXU04_RS19855	COG0181	hydroxymethylbilane synthase activity
BXU04_RS19865	COG3275	phosphorelay sensor kinase activity
BXU04_RS19895	COG0659	secondary active sulfate transmembrane transporter activity
BXU04_RS19900	COG5297	Belongs to the glycosyl hydrolase family 6
BXU04_RS19900	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BXU04_RS19970	COG0598	Magnesium transport protein CorA
BXU04_RS19980	COG1113	amino acid transport
BXU04_RS19990	COG5297	Belongs to the glycosyl hydrolase family 6
BXU04_RS19995	COG4305	rare lipoprotein A
BXU04_RS20000	COG0697	spore germination
BXU04_RS20060	COG4221	oxidoreductase activity
BXU04_RS20090	COG0456	acetyltransferase
BXU04_RS20100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BXU04_RS20130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BXU04_RS20130	COG2111	Na H antiporter
BXU04_RS20135	COG1006	Multisubunit Na H antiporter MnhC subunit
BXU04_RS20140	COG0651	ATP synthesis coupled electron transport
BXU04_RS20150	COG2212	antiporter activity
BXU04_RS20155	COG1320	monovalent cation:proton antiporter activity
BXU04_RS20165	COG3039	Transposase
BXU04_RS20175	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BXU04_RS20195	COG3104	oligopeptide transport
BXU04_RS20200	COG3483	tryptophan 2,3-dioxygenase activity
BXU04_RS20250	COG0183	Belongs to the thiolase family
BXU04_RS20300	COG3039	Transposase
BXU04_RS20330	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BXU04_RS20335	COG3023	N-Acetylmuramoyl-L-alanine amidase
BXU04_RS20345	COG4948	Mandelate Racemase Muconate Lactonizing
BXU04_RS20380	COG0531	amino acid
BXU04_RS20415	COG4682	membrane
BXU04_RS20420	COG3039	Transposase
BXU04_RS20425	COG2133	pyrroloquinoline quinone binding
BXU04_RS20460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BXU04_RS20465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BXU04_RS20475	COG1610	YqeY-like protein
BXU04_RS20485	COG1295	ribonuclease BN
BXU04_RS20490	COG0358	DNA primase activity
BXU04_RS20555	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BXU04_RS20570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BXU04_RS20620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BXU04_RS20625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BXU04_RS20630	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BXU04_RS20640	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BXU04_RS20645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BXU04_RS20660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BXU04_RS20750	COG3039	Transposase
BXU04_RS20760	COG3328	transposase activity
BXU04_RS20770	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BXU04_RS20770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BXU04_RS20780	COG1473	amidohydrolase
BXU04_RS20785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BXU04_RS20790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BXU04_RS20800	COG5383	Protein conserved in bacteria
BXU04_RS20835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BXU04_RS20840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BXU04_RS20855	COG0028	Belongs to the TPP enzyme family
BXU04_RS20860	COG4191	Histidine kinase
BXU04_RS20885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BXU04_RS20900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BXU04_RS20905	COG3177	Filamentation induced by cAMP protein fic
BXU04_RS20920	COG0596	Alpha beta hydrolase
BXU04_RS20925	COG0727	PFAM Uncharacterised protein family (UPF0153)
BXU04_RS20930	COG0318	PFAM AMP-dependent synthetase and ligase
BXU04_RS20935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BXU04_RS20985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BXU04_RS20995	COG0129	dihydroxy-acid dehydratase activity
BXU04_RS21015	COG3039	Transposase
BXU04_RS21025	COG0408	coproporphyrinogen oxidase activity
BXU04_RS21065	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BXU04_RS21130	COG2353	YceI-like domain
BXU04_RS21160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BXU04_RS21175	COG3386	PFAM SMP-30 Gluconolaconase
BXU04_RS21200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BXU04_RS21220	COG0459	protein refolding
BXU04_RS21245	COG1252	NADH dehydrogenase
BXU04_RS21255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BXU04_RS21260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BXU04_RS21265	COG2201	protein-glutamate methylesterase activity
BXU04_RS21270	COG2177	Part of the ABC transporter FtsEX involved in
BXU04_RS21275	COG2884	Cell division ATP-binding protein ftsE
BXU04_RS21285	COG3118	belongs to the thioredoxin family
BXU04_RS21290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BXU04_RS21305	COG0729	surface antigen
BXU04_RS21310	COG2911	Protein conserved in bacteria
BXU04_RS21360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BXU04_RS21410	COG1733	regulation of RNA biosynthetic process
BXU04_RS21415	COG0702	epimerase
BXU04_RS21445	COG0583	DNA-binding transcription factor activity
BXU04_RS21450	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BXU04_RS21470	COG0745	RESPONSE REGULATOR receiver
BXU04_RS21500	COG1902	pentaerythritol trinitrate reductase activity
BXU04_RS21505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BXU04_RS21515	COG2814	Major facilitator Superfamily
BXU04_RS21520	COG0583	DNA-binding transcription factor activity
BXU04_RS21535	COG0084	hydrolase, TatD family'
BXU04_RS21585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BXU04_RS21660	COG4770	biotin carboxylase activity
BXU04_RS21665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BXU04_RS21670	COG1960	acyl-CoA dehydrogenase activity
BXU04_RS21720	COG0523	cobalamin synthesis protein
BXU04_RS21740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BXU04_RS21755	COG4771	TonB-dependent receptor
BXU04_RS21760	COG0457	Tetratricopeptide repeat
BXU04_RS21770	COG0752	glycyl-tRNA synthetase alpha subunit
BXU04_RS21775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BXU04_RS21790	COG0519	Catalyzes the synthesis of GMP from XMP
BXU04_RS21790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BXU04_RS21800	COG0805	protein transport
BXU04_RS21810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BXU04_RS21820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BXU04_RS21845	COG2974	May be involved in recombination
BXU04_RS21850	COG0037	tRNA processing
BXU04_RS21870	COG3661	Belongs to the glycosyl hydrolase 67 family
BXU04_RS21880	COG4948	Mandelate Racemase Muconate Lactonizing
BXU04_RS21890	COG1472	Belongs to the glycosyl hydrolase 3 family
BXU04_RS21895	COG0246	Mannitol dehydrogenase
BXU04_RS21920	COG3693	PFAM glycoside hydrolase, family 10
BXU04_RS21945	COG2211	Major facilitator Superfamily
BXU04_RS22035	COG1846	Transcriptional regulator
BXU04_RS22040	COG1764	response to oxidative stress
BXU04_RS22125	COG3549	Plasmid maintenance system killer
BXU04_RS22135	COG1074	ATP-dependent DNA helicase activity
BXU04_RS22140	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BXU04_RS22155	COG1196	nuclear chromosome segregation
BXU04_RS22190	COG2032	superoxide dismutase activity
BXU04_RS22195	COG2032	superoxide dismutase activity
BXU04_RS22200	COG2204	response regulator
BXU04_RS22205	COG3852	Histidine kinase
BXU04_RS22210	COG0004	ammonium transporteR
BXU04_RS22215	COG0347	Belongs to the P(II) protein family
BXU04_RS22220	COG0174	glutamine synthetase
BXU04_RS22225	COG1968	undecaprenyl-diphosphatase activity
BXU04_RS22270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BXU04_RS22280	COG2062	phosphohistidine phosphatase, SixA
BXU04_RS22285	COG0489	protein tyrosine kinase activity
BXU04_RS22305	COG1396	sequence-specific DNA binding
BXU04_RS22310	COG3550	peptidyl-serine autophosphorylation
BXU04_RS22315	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BXU04_RS22320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BXU04_RS22335	COG0517	IMP dehydrogenase activity
BXU04_RS22335	COG1125	glycine betaine transport
BXU04_RS22350	COG1119	ATPase activity
BXU04_RS22360	COG1752	Esterase of the alpha-beta hydrolase superfamily
BXU04_RS22375	COG3039	Transposase
BXU04_RS22400	COG0656	L-ascorbic acid biosynthetic process
BXU04_RS22405	COG2130	NADP-dependent
BXU04_RS22410	COG0667	Aldo Keto reductase
BXU04_RS22420	COG1187	pseudouridine synthase activity
BXU04_RS22430	COG1643	Atp-dependent helicase
BXU04_RS22435	COG4807	Protein conserved in bacteria
BXU04_RS22440	COG4948	Mandelate Racemase Muconate Lactonizing
BXU04_RS22445	COG0179	Fumarylacetoacetate (FAA) hydrolase
BXU04_RS22450	COG1028	Short-chain dehydrogenase reductase Sdr
BXU04_RS22510	COG3162	membrane
BXU04_RS22515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BXU04_RS22530	COG0708	Exodeoxyribonuclease III
BXU04_RS22545	COG2091	lysine biosynthetic process via aminoadipic acid
BXU04_RS22555	COG3540	Alkaline phosphatase
BXU04_RS22605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BXU04_RS22610	COG0583	DNA-binding transcription factor activity
BXU04_RS22615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BXU04_RS22630	COG0210	DNA helicase
BXU04_RS22645	COG0531	amino acid
BXU04_RS22655	COG1322	Protein conserved in bacteria
BXU04_RS22665	COG0386	Belongs to the glutathione peroxidase family
BXU04_RS22715	COG0793	Belongs to the peptidase S41A family
BXU04_RS22720	COG4942	peptidase
BXU04_RS22730	COG2234	aminopeptidase activity
BXU04_RS22775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BXU04_RS22780	COG0302	gtp cyclohydrolase
BXU04_RS22805	COG0477	Major facilitator Superfamily
BXU04_RS22900	COG1929	Belongs to the glycerate kinase type-1 family
BXU04_RS22905	COG2271	Major facilitator Superfamily
BXU04_RS22920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BXU04_RS22925	COG0861	Integral membrane protein TerC family
BXU04_RS22935	COG0584	glycerophosphoryl diester phosphodiesterase
BXU04_RS22945	COG0671	phosphoesterase, PA-phosphatase related
BXU04_RS22955	COG0726	polysaccharide deacetylase