locus-tag	class	description
LNP58_RS00040	COG2353	YceI-like domain
LNP58_RS00050	COG2353	YceI-like domain
LNP58_RS00065	COG1760	l-serine dehydratase
LNP58_RS00075	COG0626	cystathionine gamma-synthase activity
LNP58_RS00080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LNP58_RS00085	COG0739	heme binding
LNP58_RS00095	COG1272	protein, Hemolysin III
LNP58_RS00120	COG0463	Glycosyl transferase, family 2
LNP58_RS00130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LNP58_RS00140	COG4771	TonB-dependent receptor
LNP58_RS00145	COG1309	transcriptional regulator
LNP58_RS00155	COG1960	acyl-CoA dehydrogenase activity
LNP58_RS00190	COG0509	glycine decarboxylation via glycine cleavage system
LNP58_RS00205	COG0330	HflC and HflK could
LNP58_RS00220	COG3956	TIGRFAM MazG family protein
LNP58_RS00230	COG0494	nUDIX hydrolase
LNP58_RS00240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LNP58_RS00245	COG0837	glucose binding
LNP58_RS00260	COG1388	LysM domain
LNP58_RS00260	COG3858	chitin binding
LNP58_RS00270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LNP58_RS00280	COG1472	Belongs to the glycosyl hydrolase 3 family
LNP58_RS00360	COG3537	Alpha-1,2-mannosidase
LNP58_RS00410	COG3142	Participates in the control of copper homeostasis
LNP58_RS00415	COG1446	asparaginase
LNP58_RS00425	COG2304	oxidoreductase activity
LNP58_RS00430	COG2304	oxidoreductase activity
LNP58_RS00455	COG2198	Histidine kinase
LNP58_RS00455	COG0784	Response regulator, receiver
LNP58_RS00455	COG0643	Histidine kinase
LNP58_RS00460	COG0840	transmembrane signaling receptor activity
LNP58_RS00465	COG0835	chemotaxis
LNP58_RS00480	COG0189	ligase activity
LNP58_RS00490	COG1397	ADP-ribosylglycohydrolase
LNP58_RS00500	COG1199	ATP-dependent helicase activity
LNP58_RS00510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LNP58_RS00515	COG1215	transferase activity, transferring glycosyl groups
LNP58_RS00525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LNP58_RS00580	COG1643	Atp-dependent helicase
LNP58_RS00585	COG0783	Belongs to the Dps family
LNP58_RS00590	COG0514	ATP-dependent DNA helicase (RecQ)
LNP58_RS00615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LNP58_RS00660	COG4695	Portal protein
LNP58_RS00705	COG3179	chitinase
LNP58_RS00735	COG3039	Transposase
LNP58_RS00895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LNP58_RS00950	COG1187	pseudouridine synthase activity
LNP58_RS00955	COG0602	queuosine metabolic process
LNP58_RS00965	COG2885	chlorophyll binding
LNP58_RS00980	COG0848	biopolymer transport protein
LNP58_RS00990	COG0824	Thioesterase
LNP58_RS00995	COG2255	four-way junction helicase activity
LNP58_RS01005	COG0632	four-way junction helicase activity
LNP58_RS01110	COG3209	COG3209 Rhs family protein
LNP58_RS01130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LNP58_RS01135	COG1845	cytochrome c oxidase, subunit III
LNP58_RS01140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LNP58_RS01155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LNP58_RS01160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LNP58_RS01170	COG0196	riboflavin kinase activity
LNP58_RS01175	COG0728	peptidoglycan biosynthetic process
LNP58_RS01180	COG0268	Binds directly to 16S ribosomal RNA
LNP58_RS01185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LNP58_RS01190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LNP58_RS01200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LNP58_RS01205	COG0824	Thioesterase
LNP58_RS01220	COG1946	Acyl-CoA thioesterase
LNP58_RS01250	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LNP58_RS01290	COG1877	trehalose-phosphatase activity
LNP58_RS01295	COG3387	PFAM Glycoside hydrolase 15-related
LNP58_RS01320	COG0564	pseudouridine synthase activity
LNP58_RS01325	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LNP58_RS01330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LNP58_RS01330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LNP58_RS01345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LNP58_RS01350	COG0045	succinate-CoA ligase (ADP-forming) activity
LNP58_RS01375	COG2184	nucleotidyltransferase activity
LNP58_RS01395	COG2194	sulfuric ester hydrolase activity
LNP58_RS01400	COG4969	Belongs to the N-Me-Phe pilin family
LNP58_RS01410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LNP58_RS01445	COG3039	Transposase
LNP58_RS01450	COG3039	Transposase
LNP58_RS01475	COG3039	Transposase
LNP58_RS01505	COG1132	(ABC) transporter
LNP58_RS01535	COG0745	RESPONSE REGULATOR receiver
LNP58_RS01540	COG5000	phosphorelay sensor kinase activity
LNP58_RS01540	COG5002	protein histidine kinase activity
LNP58_RS01545	COG0475	glutathione-regulated potassium exporter activity
LNP58_RS01555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LNP58_RS01575	COG1187	pseudouridine synthase activity
LNP58_RS01580	COG5001	Diguanylate cyclase
LNP58_RS01580	COG5002	protein histidine kinase activity
LNP58_RS01700	COG0415	Belongs to the DNA photolyase family
LNP58_RS01705	COG0305	Participates in initiation and elongation during chromosome replication
LNP58_RS01715	COG0367	asparagine synthase
LNP58_RS01730	COG1960	acyl-CoA dehydrogenase activity
LNP58_RS01745	COG0084	hydrolase, TatD family'
LNP58_RS01750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LNP58_RS01810	COG0735	belongs to the Fur family
LNP58_RS01815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LNP58_RS01910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LNP58_RS01920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LNP58_RS01935	COG2198	Histidine kinase
LNP58_RS01935	COG0643	Histidine kinase
LNP58_RS01940	COG0840	transmembrane signaling receptor activity
LNP58_RS01945	COG0835	chemotaxis
LNP58_RS01950	COG2202	Pas domain
LNP58_RS01950	COG2200	EAL domain
LNP58_RS01950	COG2199	diguanylate cyclase activity
LNP58_RS01955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LNP58_RS01970	COG3590	peptidase
LNP58_RS01990	COG1515	deoxyribonuclease V activity
LNP58_RS02000	COG1741	Belongs to the pirin family
LNP58_RS02050	COG3039	Transposase
LNP58_RS02095	COG3039	Transposase
LNP58_RS02130	COG1741	Belongs to the pirin family
LNP58_RS02135	COG1966	Carbon starvation protein
LNP58_RS02140	COG2879	small protein
LNP58_RS02175	COG2203	Gaf domain
LNP58_RS02175	COG3706	GGDEF domain
LNP58_RS02175	COG4251	negative regulation of phosphorylation
LNP58_RS02175	COG5001	Diguanylate cyclase
LNP58_RS02180	COG0629	single-stranded DNA binding
LNP58_RS02185	COG0142	geranyltranstransferase activity
LNP58_RS02210	COG0527	aspartate kinase activity
LNP58_RS02220	COG0384	phenazine biosynthesis protein PhzF
LNP58_RS02230	COG1764	response to oxidative stress
LNP58_RS02245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LNP58_RS02250	COG1678	Uncharacterized ACR, COG1678
LNP58_RS02260	COG0519	Catalyzes the synthesis of GMP from XMP
LNP58_RS02290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LNP58_RS02350	COG1959	2 iron, 2 sulfur cluster binding
LNP58_RS02355	COG0719	Fe-S assembly protein
LNP58_RS02360	COG0396	ATPase activity
LNP58_RS02365	COG0719	Fe-S assembly protein
LNP58_RS02370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LNP58_RS02380	COG2146	nitrite reductase [NAD(P)H] activity
LNP58_RS02415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LNP58_RS02430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LNP58_RS02440	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LNP58_RS02445	COG0174	glutamine synthetase
LNP58_RS02450	COG3328	transposase activity
LNP58_RS02475	COG0326	Molecular chaperone. Has ATPase activity
LNP58_RS02480	COG2207	Transcriptional regulator
LNP58_RS02510	COG0657	acetylesterase activity
LNP58_RS02510	COG2755	lipolytic protein G-D-S-L family
LNP58_RS02535	COG0488	(ABC) transporter
LNP58_RS02570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LNP58_RS02570	COG4651	solute:proton antiporter activity
LNP58_RS02585	COG4772	TonB-dependent receptor
LNP58_RS02595	COG4264	IucA IucC family
LNP58_RS02600	COG2814	Major facilitator Superfamily
LNP58_RS02610	COG0019	diaminopimelate decarboxylase activity
LNP58_RS02675	COG4206	TonB-dependent receptor
LNP58_RS02710	COG0542	response to heat
LNP58_RS02745	COG0534	Mate efflux family protein
LNP58_RS02760	COG0336	Belongs to the RNA methyltransferase TrmD family
LNP58_RS02765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LNP58_RS02770	COG0228	four-way junction DNA binding
LNP58_RS02790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LNP58_RS02800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LNP58_RS02840	COG1555	photosystem II stabilization
LNP58_RS02845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LNP58_RS02860	COG3178	'Phosphotransferase
LNP58_RS02865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LNP58_RS02875	COG0628	permease
LNP58_RS02885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LNP58_RS02900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LNP58_RS02925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LNP58_RS02930	COG0271	Belongs to the BolA IbaG family
LNP58_RS02940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LNP58_RS02950	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LNP58_RS02955	COG1137	ATPase activity
LNP58_RS02970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LNP58_RS02975	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LNP58_RS02980	COG1660	Displays ATPase and GTPase activities
LNP58_RS02990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LNP58_RS02995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LNP58_RS03000	COG2239	Acts as a magnesium transporter
LNP58_RS03010	COG1294	oxidase, subunit
LNP58_RS03015	COG1271	oxidase subunit
LNP58_RS03030	COG1113	amino acid transport
LNP58_RS03045	COG2197	response regulator
LNP58_RS03050	COG0531	amino acid
LNP58_RS03110	COG0754	glutathionylspermidine amidase activity
LNP58_RS03135	COG1842	Phage shock protein A
LNP58_RS03150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LNP58_RS03155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LNP58_RS03165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LNP58_RS03195	COG2201	protein-glutamate methylesterase activity
LNP58_RS03245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LNP58_RS03290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LNP58_RS03295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LNP58_RS03340	COG0745	RESPONSE REGULATOR receiver
LNP58_RS03345	COG2205	protein histidine kinase activity
LNP58_RS03365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LNP58_RS03395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LNP58_RS03395	COG3453	Protein conserved in bacteria
LNP58_RS03400	COG0725	ABC transporter, periplasmic molybdate-binding protein
LNP58_RS03405	COG4149	molybdate abc transporter
LNP58_RS03410	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LNP58_RS03430	COG0642	Histidine kinase
LNP58_RS03445	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS03455	COG1022	Amp-dependent synthetase and ligase
LNP58_RS03480	COG1376	ErfK ybiS ycfS ynhG family protein
LNP58_RS03485	COG0739	heme binding
LNP58_RS03495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LNP58_RS03500	COG1301	dicarboxylic acid transport
LNP58_RS03520	COG2304	oxidoreductase activity
LNP58_RS03540	COG0714	Associated with various cellular activities
LNP58_RS03590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LNP58_RS03620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LNP58_RS03630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LNP58_RS03655	COG1561	YicC-like family, N-terminal region
LNP58_RS03660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LNP58_RS03675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LNP58_RS03715	COG0006	proline dipeptidase activity
LNP58_RS03740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LNP58_RS03760	COG2912	Transglutaminase-like superfamily
LNP58_RS03765	COG1773	rubredoxin
LNP58_RS03770	COG0352	thiamine-phosphate diphosphorylase activity
LNP58_RS03800	COG0281	malic enzyme
LNP58_RS03800	COG0280	phosphate acetyltransferase
LNP58_RS03820	COG4191	Histidine kinase
LNP58_RS03835	COG0583	DNA-binding transcription factor activity
LNP58_RS03855	COG2197	response regulator
LNP58_RS03865	COG0642	Histidine kinase
LNP58_RS03880	COG2851	Citrate transporter
LNP58_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS03890	COG1609	Transcriptional regulator
LNP58_RS03900	COG2211	Major facilitator Superfamily
LNP58_RS03950	COG0726	polysaccharide deacetylase
LNP58_RS03955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LNP58_RS03980	COG3039	Transposase
LNP58_RS04025	COG0242	peptide deformylase activity
LNP58_RS04045	COG0714	Associated with various cellular activities
LNP58_RS04065	COG0537	adenosine 5'-monophosphoramidase activity
LNP58_RS04095	COG0314	molybdopterin synthase activity
LNP58_RS04100	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LNP58_RS04105	COG0315	cyclic pyranopterin monophosphate synthase activity
LNP58_RS04115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LNP58_RS04120	COG1234	tRNA 3'-trailer cleavage
LNP58_RS04125	COG3642	lipopolysaccharide core region biosynthetic process
LNP58_RS04130	COG0859	PFAM glycosyl transferase family 9
LNP58_RS04140	COG0582	viral genome integration into host DNA
LNP58_RS04200	COG0631	protein serine/threonine phosphatase activity
LNP58_RS04210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LNP58_RS04235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LNP58_RS04275	COG0544	peptidyl-prolyl cis-trans isomerase activity
LNP58_RS04330	COG0473	3-isopropylmalate dehydrogenase activity
LNP58_RS04355	COG0584	glycerophosphoryl diester phosphodiesterase
LNP58_RS04375	COG3039	Transposase
LNP58_RS04510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LNP58_RS04530	COG1217	gtp-binding protein TYPA
LNP58_RS04535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LNP58_RS04545	COG0625	glutathione transferase activity
LNP58_RS04560	COG3781	membrane
LNP58_RS04570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LNP58_RS04600	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LNP58_RS04620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LNP58_RS04645	COG3710	Transcriptional regulator
LNP58_RS04650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LNP58_RS04660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LNP58_RS04695	COG0066	3-isopropylmalate dehydratase activity
LNP58_RS04700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LNP58_RS04720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LNP58_RS04725	COG1538	Outer membrane efflux protein
LNP58_RS04730	COG1519	Transferase
LNP58_RS04735	COG1560	Kdo2-lipid A biosynthetic process
LNP58_RS04755	COG3039	Transposase
LNP58_RS04790	COG0308	aminopeptidase N
LNP58_RS04805	COG0330	HflC and HflK could
LNP58_RS04810	COG0330	HflC and HflK could
LNP58_RS04830	COG0678	peroxiredoxin activity
LNP58_RS04840	COG2826	transposase and inactivated derivatives, IS30 family
LNP58_RS04870	COG3039	Transposase
LNP58_RS04895	COG3039	Transposase
LNP58_RS04925	COG3829	transcription factor binding
LNP58_RS04960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LNP58_RS04965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LNP58_RS04975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LNP58_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS05005	COG1399	metal-binding, possibly nucleic acid-binding protein
LNP58_RS05045	COG1518	maintenance of DNA repeat elements
LNP58_RS05050	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LNP58_RS05095	COG2188	Transcriptional regulator
LNP58_RS05110	COG1450	Type ii and iii secretion system protein
LNP58_RS05125	COG3166	PFAM Fimbrial assembly family protein
LNP58_RS05130	COG3156	type II secretion system protein K
LNP58_RS05135	COG4795	General secretion pathway protein
LNP58_RS05140	COG2165	general secretion pathway protein
LNP58_RS05145	COG4970	Tfp pilus assembly protein FimT
LNP58_RS05150	COG2165	general secretion pathway protein
LNP58_RS05155	COG1459	type II secretion system
LNP58_RS05165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LNP58_RS05185	COG5295	Hep Hag repeat protein
LNP58_RS05190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LNP58_RS05190	COG0047	phosphoribosylformylglycinamidine synthase activity
LNP58_RS05195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LNP58_RS05200	COG4974	Belongs to the 'phage' integrase family
LNP58_RS05215	COG0795	lipopolysaccharide-transporting ATPase activity
LNP58_RS05225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LNP58_RS05240	COG0525	valine-tRNA ligase activity
LNP58_RS05280	COG3039	Transposase
LNP58_RS05305	COG3039	Transposase
LNP58_RS05330	COG1183	phosphatidylcholine synthase activity
LNP58_RS05340	COG0442	prolyl-tRNA aminoacylation
LNP58_RS05355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LNP58_RS05360	COG1127	ABC transporter
LNP58_RS05365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LNP58_RS05365	COG3218	ABC-type transport auxiliary lipoprotein component
LNP58_RS05400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LNP58_RS05405	COG0662	Cupin 2, conserved barrel domain protein
LNP58_RS05405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LNP58_RS05430	COG2086	electron transfer activity
LNP58_RS05455	COG3328	transposase activity
LNP58_RS05495	COG0626	cystathionine gamma-synthase activity
LNP58_RS05535	COG0513	Belongs to the DEAD box helicase family
LNP58_RS05540	COG0720	synthase
LNP58_RS05550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LNP58_RS05555	COG1956	GAF domain-containing protein
LNP58_RS05590	COG0339	signal peptide processing
LNP58_RS05645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LNP58_RS05650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LNP58_RS05700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LNP58_RS05705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LNP58_RS05710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LNP58_RS05715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LNP58_RS05725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LNP58_RS05735	COG0356	it plays a direct role in the translocation of protons across the membrane
LNP58_RS05755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LNP58_RS05765	COG0508	dehydrogenase complex catalyzes the overall conversion of
LNP58_RS05795	COG2011	ABC-type metal ion transport system permease component
LNP58_RS05805	COG0697	spore germination
LNP58_RS05845	COG1187	pseudouridine synthase activity
LNP58_RS05850	COG2813	Specifically methylates the guanine in position
LNP58_RS05880	COG2205	protein histidine kinase activity
LNP58_RS05880	COG2202	Pas domain
LNP58_RS05905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LNP58_RS05955	COG0745	RESPONSE REGULATOR receiver
LNP58_RS05970	COG1404	Belongs to the peptidase S8 family
LNP58_RS05990	COG0842	Transport permease protein
LNP58_RS05995	COG1131	(ABC) transporter
LNP58_RS06000	COG0025	NhaP-type Na H and K H
LNP58_RS06010	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LNP58_RS06020	COG1573	uracil-dna glycosylase
LNP58_RS06030	COG3384	dioxygenase
LNP58_RS06045	COG0667	Aldo Keto reductase
LNP58_RS06060	COG3590	peptidase
LNP58_RS06080	COG0531	amino acid
LNP58_RS06095	COG2972	Histidine kinase
LNP58_RS06120	COG2204	response regulator
LNP58_RS06130	COG1271	oxidase subunit
LNP58_RS06135	COG1294	oxidase, subunit
LNP58_RS06290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LNP58_RS06300	COG1560	Kdo2-lipid A biosynthetic process
LNP58_RS06350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LNP58_RS06350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LNP58_RS06355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LNP58_RS06360	COG0242	peptide deformylase activity
LNP58_RS06365	COG1652	LysM domain
LNP58_RS06370	COG0758	DNA mediated transformation
LNP58_RS06375	COG2922	Belongs to the Smg family
LNP58_RS06390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LNP58_RS06390	COG1754	DNA topoisomerase type I activity
LNP58_RS06395	COG0009	L-threonylcarbamoyladenylate synthase
LNP58_RS06410	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS06420	COG0616	signal peptide processing
LNP58_RS06425	COG0534	Mate efflux family protein
LNP58_RS06445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LNP58_RS06480	COG1324	tolerance protein
LNP58_RS06490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LNP58_RS06495	COG0511	ligase activity, forming carbon-carbon bonds
LNP58_RS06505	COG0439	Biotin carboxylase
LNP58_RS06545	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LNP58_RS06580	COG0419	ATPase involved in DNA repair
LNP58_RS06590	COG0151	Belongs to the GarS family
LNP58_RS06595	COG0577	efflux transmembrane transporter activity
LNP58_RS06595	COG1136	(ABC) transporter
LNP58_RS06605	COG1289	transmembrane transporter activity
LNP58_RS06620	COG2814	Major facilitator Superfamily
LNP58_RS06635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LNP58_RS06675	COG0745	RESPONSE REGULATOR receiver
LNP58_RS06720	COG0739	heme binding
LNP58_RS06735	COG2211	Major facilitator Superfamily
LNP58_RS06745	COG0708	Exodeoxyribonuclease III
LNP58_RS06760	COG1192	Involved in chromosome partitioning
LNP58_RS06765	COG1475	DNA binding
LNP58_RS06780	COG0463	Glycosyl transferase, family 2
LNP58_RS06805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LNP58_RS06810	COG2003	Belongs to the UPF0758 family
LNP58_RS06815	COG0018	arginyl-trna synthetase
LNP58_RS06830	COG4221	oxidoreductase activity
LNP58_RS06855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LNP58_RS06860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LNP58_RS06865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LNP58_RS06875	COG3485	protocatechuate 3,4-dioxygenase
LNP58_RS06880	COG3485	protocatechuate 3,4-dioxygenase
LNP58_RS06915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LNP58_RS06920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LNP58_RS06930	COG0045	succinate-CoA ligase (ADP-forming) activity
LNP58_RS06930	COG1042	CoA-binding domain protein
LNP58_RS06930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LNP58_RS06940	COG2239	Acts as a magnesium transporter
LNP58_RS06955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LNP58_RS06960	COG3387	PFAM Glycoside hydrolase 15-related
LNP58_RS06975	COG3100	YcgL domain-containing protein
LNP58_RS06980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LNP58_RS06990	COG0463	Glycosyl transferase, family 2
LNP58_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS07015	COG0156	8-amino-7-oxononanoate synthase activity
LNP58_RS07020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LNP58_RS07025	COG1040	competence protein
LNP58_RS07030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LNP58_RS07040	COG0628	permease
LNP58_RS07050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LNP58_RS07060	COG1595	DNA-templated transcription, initiation
LNP58_RS07065	COG0753	catalase activity
LNP58_RS07110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LNP58_RS07115	COG0180	Tryptophanyl-tRNA synthetase
LNP58_RS07120	COG3237	CsbD-like
LNP58_RS07155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LNP58_RS07170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LNP58_RS07175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LNP58_RS07175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LNP58_RS07185	COG3228	Belongs to the MtfA family
LNP58_RS07215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LNP58_RS07255	COG1199	ATP-dependent helicase activity
LNP58_RS07295	COG0583	DNA-binding transcription factor activity
LNP58_RS07340	COG0625	glutathione transferase activity
LNP58_RS07375	COG4555	ABC transporter
LNP58_RS07385	COG1476	TRANSCRIPTIONal
LNP58_RS07410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LNP58_RS07415	COG1131	(ABC) transporter
LNP58_RS07420	COG0842	Transport permease protein
LNP58_RS07430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LNP58_RS07510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LNP58_RS07520	COG0564	pseudouridine synthase activity
LNP58_RS07550	COG0339	signal peptide processing
LNP58_RS07585	COG3254	rhamnose metabolic process
LNP58_RS07590	COG0738	Major facilitator superfamily
LNP58_RS07595	COG1414	Transcriptional regulator
LNP58_RS07605	COG2205	protein histidine kinase activity
LNP58_RS07615	COG3459	Glycosyltransferase 36 associated
LNP58_RS07620	COG2211	Major facilitator Superfamily
LNP58_RS07625	COG3265	gluconokinase activity
LNP58_RS07635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LNP58_RS07710	COG1127	ABC transporter
LNP58_RS07715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LNP58_RS07720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LNP58_RS07735	COG2853	Lipoprotein
LNP58_RS07755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LNP58_RS07820	COG0676	glucose-6-phosphate 1-epimerase activity
LNP58_RS07825	COG3039	Transposase
LNP58_RS07850	COG3039	Transposase
LNP58_RS07855	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LNP58_RS07865	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LNP58_RS07875	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LNP58_RS07880	COG1064	alcohol dehydrogenase
LNP58_RS07925	COG1522	sequence-specific DNA binding
LNP58_RS07930	COG3186	Phenylalanine-4-hydroxylase
LNP58_RS07970	COG2937	Belongs to the GPAT DAPAT family
LNP58_RS08005	COG0284	orotidine-5'-phosphate decarboxylase activity
LNP58_RS08010	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LNP58_RS08015	COG3132	Protein of unknown function, DUF480
LNP58_RS08030	COG0210	DNA helicase
LNP58_RS08045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LNP58_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS08095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LNP58_RS08160	COG1166	arginine decarboxylase activity
LNP58_RS08165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LNP58_RS08205	COG0606	chelatase, subunit chli
LNP58_RS08250	COG0366	Alpha amylase catalytic
LNP58_RS08255	COG0366	Alpha amylase catalytic
LNP58_RS08280	COG1609	Transcriptional regulator
LNP58_RS08330	COG0493	'glutamate synthase
LNP58_RS08335	COG0067	glutamate synthase
LNP58_RS08335	COG0069	glutamate synthase activity
LNP58_RS08335	COG0070	glutamate synthase
LNP58_RS08395	COG1111	helicase
LNP58_RS08395	COG1205	dead DEAH box helicase
LNP58_RS08400	COG1272	protein, Hemolysin III
LNP58_RS08440	COG1136	(ABC) transporter
LNP58_RS08500	COG2826	transposase and inactivated derivatives, IS30 family
LNP58_RS08525	COG3039	Transposase
LNP58_RS08535	COG1090	epimerase
LNP58_RS08555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LNP58_RS08665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LNP58_RS08740	COG3264	Mechanosensitive ion channel
LNP58_RS08740	COG1511	domain protein
LNP58_RS08765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LNP58_RS08770	COG2354	Protein conserved in bacteria
LNP58_RS08775	COG1649	PFAM Uncharacterised BCR, COG1649
LNP58_RS08795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LNP58_RS08820	COG0702	epimerase
LNP58_RS08835	COG1858	cytochrome C peroxidase
LNP58_RS08880	COG3039	Transposase
LNP58_RS08930	COG0513	Belongs to the DEAD box helicase family
LNP58_RS08935	COG3039	Transposase
LNP58_RS08975	COG1136	(ABC) transporter
LNP58_RS08985	COG3039	Transposase
LNP58_RS08995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LNP58_RS09020	COG1755	Isoprenylcysteine carboxyl methyltransferase
LNP58_RS09025	COG1304	FMN binding
LNP58_RS09030	COG3039	Transposase
LNP58_RS09045	COG4772	TonB-dependent receptor
LNP58_RS09055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LNP58_RS09065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LNP58_RS09105	COG0501	Belongs to the peptidase M48B family
LNP58_RS09115	COG0187	DNA topoisomerase II activity
LNP58_RS09130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LNP58_RS09150	COG0726	polysaccharide deacetylase
LNP58_RS09160	COG0671	phosphoesterase, PA-phosphatase related
LNP58_RS09170	COG0584	glycerophosphoryl diester phosphodiesterase
LNP58_RS09180	COG0861	Integral membrane protein TerC family
LNP58_RS09185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LNP58_RS09200	COG2271	Major facilitator Superfamily
LNP58_RS09205	COG1929	Belongs to the glycerate kinase type-1 family
LNP58_RS09300	COG0477	Major facilitator Superfamily
LNP58_RS09335	COG0302	gtp cyclohydrolase
LNP58_RS09340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LNP58_RS09385	COG2234	aminopeptidase activity
LNP58_RS09395	COG4942	peptidase
LNP58_RS09400	COG0793	Belongs to the peptidase S41A family
LNP58_RS09450	COG0386	Belongs to the glutathione peroxidase family
LNP58_RS09460	COG1322	Protein conserved in bacteria
LNP58_RS09470	COG0531	amino acid
LNP58_RS09485	COG0210	DNA helicase
LNP58_RS09500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LNP58_RS09505	COG0583	DNA-binding transcription factor activity
LNP58_RS09510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LNP58_RS09560	COG3540	Alkaline phosphatase
LNP58_RS09570	COG2091	lysine biosynthetic process via aminoadipic acid
LNP58_RS09585	COG0708	Exodeoxyribonuclease III
LNP58_RS09600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LNP58_RS09605	COG3162	membrane
LNP58_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS09670	COG0179	Fumarylacetoacetate (FAA) hydrolase
LNP58_RS09675	COG4948	Mandelate Racemase Muconate Lactonizing
LNP58_RS09680	COG4807	Protein conserved in bacteria
LNP58_RS09685	COG1643	Atp-dependent helicase
LNP58_RS09695	COG1187	pseudouridine synthase activity
LNP58_RS09705	COG0667	Aldo Keto reductase
LNP58_RS09710	COG2130	NADP-dependent
LNP58_RS09715	COG0656	L-ascorbic acid biosynthetic process
LNP58_RS09740	COG3039	Transposase
LNP58_RS09755	COG1752	Esterase of the alpha-beta hydrolase superfamily
LNP58_RS09765	COG1119	ATPase activity
LNP58_RS09780	COG0517	IMP dehydrogenase activity
LNP58_RS09780	COG1125	glycine betaine transport
LNP58_RS09795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LNP58_RS09800	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LNP58_RS09805	COG3550	peptidyl-serine autophosphorylation
LNP58_RS09810	COG1396	sequence-specific DNA binding
LNP58_RS09830	COG0489	protein tyrosine kinase activity
LNP58_RS09835	COG2062	phosphohistidine phosphatase, SixA
LNP58_RS09845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LNP58_RS09885	COG1968	undecaprenyl-diphosphatase activity
LNP58_RS09890	COG0174	glutamine synthetase
LNP58_RS09895	COG0347	Belongs to the P(II) protein family
LNP58_RS09900	COG0004	ammonium transporteR
LNP58_RS09905	COG3852	Histidine kinase
LNP58_RS09910	COG2204	response regulator
LNP58_RS09915	COG2032	superoxide dismutase activity
LNP58_RS09920	COG2032	superoxide dismutase activity
LNP58_RS09960	COG1196	nuclear chromosome segregation
LNP58_RS09975	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LNP58_RS09980	COG1074	ATP-dependent DNA helicase activity
LNP58_RS09990	COG3549	Plasmid maintenance system killer
LNP58_RS10075	COG1764	response to oxidative stress
LNP58_RS10080	COG1846	Transcriptional regulator
LNP58_RS10170	COG2211	Major facilitator Superfamily
LNP58_RS10195	COG3693	PFAM glycoside hydrolase, family 10
LNP58_RS10220	COG0246	Mannitol dehydrogenase
LNP58_RS10225	COG1472	Belongs to the glycosyl hydrolase 3 family
LNP58_RS10235	COG4948	Mandelate Racemase Muconate Lactonizing
LNP58_RS10245	COG3661	Belongs to the glycosyl hydrolase 67 family
LNP58_RS10295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LNP58_RS10305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LNP58_RS10315	COG0805	protein transport
LNP58_RS10325	COG0519	Catalyzes the synthesis of GMP from XMP
LNP58_RS10325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LNP58_RS10340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LNP58_RS10355	COG0457	Tetratricopeptide repeat
LNP58_RS10360	COG4771	TonB-dependent receptor
LNP58_RS10380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LNP58_RS10400	COG0523	cobalamin synthesis protein
LNP58_RS10455	COG1960	acyl-CoA dehydrogenase activity
LNP58_RS10460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LNP58_RS10465	COG4770	biotin carboxylase activity
LNP58_RS10540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LNP58_RS10590	COG0084	hydrolase, TatD family'
LNP58_RS10605	COG0583	DNA-binding transcription factor activity
LNP58_RS10610	COG2814	Major facilitator Superfamily
LNP58_RS10620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LNP58_RS10625	COG1902	pentaerythritol trinitrate reductase activity
LNP58_RS10655	COG0745	RESPONSE REGULATOR receiver
LNP58_RS10675	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LNP58_RS10680	COG0583	DNA-binding transcription factor activity
LNP58_RS10710	COG0702	epimerase
LNP58_RS10715	COG1733	regulation of RNA biosynthetic process
LNP58_RS10770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LNP58_RS10820	COG2911	Protein conserved in bacteria
LNP58_RS10825	COG0729	surface antigen
LNP58_RS10845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LNP58_RS10850	COG3118	belongs to the thioredoxin family
LNP58_RS10860	COG2884	Cell division ATP-binding protein ftsE
LNP58_RS10865	COG2177	Part of the ABC transporter FtsEX involved in
LNP58_RS10870	COG2201	protein-glutamate methylesterase activity
LNP58_RS10875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LNP58_RS10880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LNP58_RS10890	COG1252	NADH dehydrogenase
LNP58_RS10920	COG0459	protein refolding
LNP58_RS10940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LNP58_RS10965	COG3386	PFAM SMP-30 Gluconolaconase
LNP58_RS10980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LNP58_RS11010	COG2353	YceI-like domain
LNP58_RS11100	COG0408	coproporphyrinogen oxidase activity
LNP58_RS11110	COG3039	Transposase
LNP58_RS11135	COG0129	dihydroxy-acid dehydratase activity
LNP58_RS11145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LNP58_RS11195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LNP58_RS11200	COG0318	PFAM AMP-dependent synthetase and ligase
LNP58_RS11205	COG0727	PFAM Uncharacterised protein family (UPF0153)
LNP58_RS11210	COG0596	Alpha beta hydrolase
LNP58_RS11225	COG3177	Filamentation induced by cAMP protein fic
LNP58_RS11230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LNP58_RS11245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LNP58_RS11270	COG4191	Histidine kinase
LNP58_RS11275	COG0028	Belongs to the TPP enzyme family
LNP58_RS11290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LNP58_RS11295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LNP58_RS11330	COG5383	Protein conserved in bacteria
LNP58_RS11340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LNP58_RS11345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LNP58_RS11350	COG1473	amidohydrolase
LNP58_RS11360	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LNP58_RS11360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LNP58_RS11370	COG3328	transposase activity
LNP58_RS11460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LNP58_RS11475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LNP58_RS11480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LNP58_RS11490	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LNP58_RS11495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LNP58_RS11500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LNP58_RS11550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LNP58_RS11565	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LNP58_RS11630	COG0358	DNA primase activity
LNP58_RS11635	COG1295	ribonuclease BN
LNP58_RS11645	COG1610	YqeY-like protein
LNP58_RS11655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LNP58_RS11660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LNP58_RS11695	COG2133	pyrroloquinoline quinone binding
LNP58_RS11700	COG4682	membrane
LNP58_RS11735	COG0531	amino acid
LNP58_RS11770	COG4948	Mandelate Racemase Muconate Lactonizing
LNP58_RS11780	COG3023	N-Acetylmuramoyl-L-alanine amidase
LNP58_RS11785	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LNP58_RS11815	COG3039	Transposase
LNP58_RS11865	COG0183	Belongs to the thiolase family
LNP58_RS11915	COG3483	tryptophan 2,3-dioxygenase activity
LNP58_RS11920	COG3104	oligopeptide transport
LNP58_RS11940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LNP58_RS11945	COG3039	Transposase
LNP58_RS11955	COG1320	monovalent cation:proton antiporter activity
LNP58_RS11960	COG2212	antiporter activity
LNP58_RS11970	COG0651	ATP synthesis coupled electron transport
LNP58_RS11975	COG1006	Multisubunit Na H antiporter MnhC subunit
LNP58_RS11980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LNP58_RS11980	COG2111	Na H antiporter
LNP58_RS12010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LNP58_RS12020	COG0456	acetyltransferase
LNP58_RS12050	COG4221	oxidoreductase activity
LNP58_RS12110	COG0697	spore germination
LNP58_RS12115	COG4305	rare lipoprotein A
LNP58_RS12120	COG5297	Belongs to the glycosyl hydrolase family 6
LNP58_RS12130	COG1113	amino acid transport
LNP58_RS12140	COG0598	Magnesium transport protein CorA
LNP58_RS12210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LNP58_RS12210	COG5297	Belongs to the glycosyl hydrolase family 6
LNP58_RS12215	COG0659	secondary active sulfate transmembrane transporter activity
LNP58_RS12250	COG3275	phosphorelay sensor kinase activity
LNP58_RS12260	COG0181	hydroxymethylbilane synthase activity
LNP58_RS12285	COG1505	serine-type exopeptidase activity
LNP58_RS12300	COG0436	Aminotransferase
LNP58_RS12330	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LNP58_RS12360	COG0308	aminopeptidase N
LNP58_RS12365	COG2199	diguanylate cyclase activity
LNP58_RS12410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LNP58_RS12415	COG1077	Cell shape determining protein MreB Mrl
LNP58_RS12420	COG1792	Involved in formation and maintenance of cell shape
LNP58_RS12435	COG0772	Belongs to the SEDS family
LNP58_RS12480	COG2951	lytic endotransglycosylase activity
LNP58_RS12485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LNP58_RS12490	COG1686	Belongs to the peptidase S11 family
LNP58_RS12505	COG2921	Belongs to the UPF0250 family
LNP58_RS12555	COG1056	cytidyltransferase-related domain
LNP58_RS12555	COG1051	belongs to the nudix hydrolase family
LNP58_RS12590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LNP58_RS12595	COG0673	inositol 2-dehydrogenase activity
LNP58_RS12600	COG2823	Periplasmic or secreted lipoprotein
LNP58_RS12605	COG4251	negative regulation of phosphorylation
LNP58_RS12610	COG0784	Response regulator, receiver
LNP58_RS12615	COG4191	Histidine kinase
LNP58_RS12620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LNP58_RS12660	COG3250	beta-galactosidase activity
LNP58_RS12675	COG2188	Transcriptional regulator
LNP58_RS12685	COG1609	Transcriptional regulator
LNP58_RS12690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LNP58_RS12695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LNP58_RS12705	COG1215	transferase activity, transferring glycosyl groups
LNP58_RS12710	COG0726	polysaccharide deacetylase
LNP58_RS12710	COG1649	PFAM Uncharacterised BCR, COG1649
LNP58_RS12750	COG3039	Transposase
LNP58_RS12805	COG3039	Transposase
LNP58_RS12820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LNP58_RS12825	COG3039	Transposase
LNP58_RS12860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LNP58_RS12915	COG2205	protein histidine kinase activity
LNP58_RS12940	COG3791	Glutathione-dependent formaldehyde-activating
LNP58_RS12965	COG0488	(ABC) transporter
LNP58_RS12985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LNP58_RS13005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LNP58_RS13005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LNP58_RS13025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LNP58_RS13030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LNP58_RS13035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LNP58_RS13055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LNP58_RS13060	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LNP58_RS13070	COG2205	protein histidine kinase activity
LNP58_RS13075	COG0745	RESPONSE REGULATOR receiver
LNP58_RS13080	COG0277	FAD linked oxidase domain protein
LNP58_RS13085	COG1988	membrane-bound metal-dependent
LNP58_RS13090	COG0792	nuclease activity
LNP58_RS13125	COG0275	rRNA processing
LNP58_RS13130	COG3116	cell division
LNP58_RS13145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LNP58_RS13165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LNP58_RS13170	COG1181	Belongs to the D-alanine--D-alanine ligase family
LNP58_RS13175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LNP58_RS13190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LNP58_RS13200	COG1388	LysM domain
LNP58_RS13200	COG4942	peptidase
LNP58_RS13215	COG0494	nUDIX hydrolase
LNP58_RS13230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LNP58_RS13240	COG3321	synthase
LNP58_RS13240	COG0604	alcohol dehydrogenase
LNP58_RS13240	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS13295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LNP58_RS13345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LNP58_RS13360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LNP58_RS13370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LNP58_RS13375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LNP58_RS13385	COG0667	Aldo Keto reductase
LNP58_RS13435	COG2175	clavaminate synthase activity
LNP58_RS13445	COG4181	ATPase activity
LNP58_RS13460	COG0642	Histidine kinase
LNP58_RS13475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LNP58_RS13495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LNP58_RS13520	COG2967	ApaG domain
LNP58_RS13525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LNP58_RS13535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LNP58_RS13550	COG0123	including yeast histone deacetylase and acetoin utilization protein
LNP58_RS13555	COG2096	Adenosyltransferase
LNP58_RS13565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LNP58_RS13570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LNP58_RS13610	COG0583	DNA-binding transcription factor activity
LNP58_RS13615	COG0318	PFAM AMP-dependent synthetase and ligase
LNP58_RS13625	COG1024	Enoyl-CoA hydratase
LNP58_RS13645	COG3386	PFAM SMP-30 Gluconolaconase
LNP58_RS13775	COG0446	pyridine nucleotide-disulphide oxidoreductase
LNP58_RS13775	COG1902	pentaerythritol trinitrate reductase activity
LNP58_RS13780	COG0604	alcohol dehydrogenase
LNP58_RS13805	COG0156	8-amino-7-oxononanoate synthase activity
LNP58_RS13810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LNP58_RS13815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LNP58_RS13820	COG4208	sulfate ABC transporter
LNP58_RS13825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LNP58_RS13855	COG0406	alpha-ribazole phosphatase activity
LNP58_RS13865	COG0285	dihydrofolate synthase activity
LNP58_RS13885	COG2833	Protein of unknown function (DUF455)
LNP58_RS13905	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LNP58_RS13910	COG0671	phosphoesterase, PA-phosphatase related
LNP58_RS13915	COG0438	transferase activity, transferring glycosyl groups
LNP58_RS13925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LNP58_RS13940	COG4783	chaperone-mediated protein folding
LNP58_RS14000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LNP58_RS14005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LNP58_RS14010	COG0583	DNA-binding transcription factor activity
LNP58_RS14015	COG3634	alkyl hydroperoxide reductase activity
LNP58_RS14025	COG2890	protein-(glutamine-N5) methyltransferase activity
LNP58_RS14075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LNP58_RS14075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LNP58_RS14090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LNP58_RS14115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LNP58_RS14140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LNP58_RS14150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LNP58_RS14180	COG1295	ribonuclease BN
LNP58_RS14185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LNP58_RS14205	COG0521	Mo-molybdopterin cofactor biosynthetic process
LNP58_RS14215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LNP58_RS14230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LNP58_RS14245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LNP58_RS14255	COG0193	aminoacyl-tRNA hydrolase activity
LNP58_RS14260	COG0012	GTP binding
LNP58_RS14290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LNP58_RS14295	COG0250	Participates in transcription elongation, termination and antitermination
LNP58_RS14300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LNP58_RS14310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LNP58_RS14315	COG0222	ribosome binding
LNP58_RS14320	COG0085	RNA polymerase activity
LNP58_RS14325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LNP58_RS14330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LNP58_RS14335	COG0049	tRNA binding
LNP58_RS14355	COG0051	transcription antitermination factor activity, RNA binding
LNP58_RS14360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LNP58_RS14365	COG0088	Forms part of the polypeptide exit tunnel
LNP58_RS14370	COG0089	rRNA binding
LNP58_RS14385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LNP58_RS14395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LNP58_RS14400	COG0255	Belongs to the universal ribosomal protein uL29 family
LNP58_RS14405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LNP58_RS14410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LNP58_RS14420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LNP58_RS14450	COG1841	ribosomal large subunit assembly
LNP58_RS14460	COG0201	protein transport
LNP58_RS14470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LNP58_RS14475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LNP58_RS14485	COG0203	ribosomal protein L17
LNP58_RS14545	COG3551	Protein conserved in bacteria
LNP58_RS14575	COG2194	sulfuric ester hydrolase activity
LNP58_RS14585	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LNP58_RS14590	COG0745	RESPONSE REGULATOR receiver
LNP58_RS14595	COG0642	Histidine kinase
LNP58_RS14605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LNP58_RS14610	COG2894	cell division
LNP58_RS14625	COG4585	Histidine kinase
LNP58_RS14630	COG2197	response regulator
LNP58_RS14645	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LNP58_RS14740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LNP58_RS14750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LNP58_RS14815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LNP58_RS14890	COG3039	Transposase
LNP58_RS14945	COG3179	chitinase
LNP58_RS15120	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LNP58_RS15140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LNP58_RS15145	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
LNP58_RS15150	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
LNP58_RS15165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LNP58_RS15205	COG3039	Transposase
LNP58_RS15265	COG1297	OPT oligopeptide transporter protein
LNP58_RS15270	COG3039	Transposase
LNP58_RS15290	COG0823	Involved in the tonB-independent uptake of proteins
LNP58_RS15290	COG1506	peptidase
LNP58_RS15320	COG1917	Cupin 2, conserved barrel domain protein
LNP58_RS15320	COG2207	Transcriptional regulator
LNP58_RS15370	COG0753	catalase activity
LNP58_RS15410	COG0469	pyruvate kinase activity
LNP58_RS15415	COG3588	fructose-bisphosphate aldolase
LNP58_RS15420	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LNP58_RS15465	COG0784	Response regulator, receiver
LNP58_RS15465	COG2198	Histidine kinase
LNP58_RS15465	COG2205	protein histidine kinase activity
LNP58_RS15485	COG0175	sulfate reduction
LNP58_RS15490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LNP58_RS15495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LNP58_RS15500	COG0175	sulfate reduction
LNP58_RS15505	COG0529	Catalyzes the synthesis of activated sulfate
LNP58_RS15505	COG2895	sulfate adenylyltransferase (ATP) activity
LNP58_RS15515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LNP58_RS15520	COG0308	aminopeptidase N
LNP58_RS15540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LNP58_RS15545	COG2272	Belongs to the type-B carboxylesterase lipase family
LNP58_RS15565	COG1970	mechanosensitive ion channel activity
LNP58_RS15595	COG3273	potassium ion transport
LNP58_RS15595	COG0471	metal ion transport
LNP58_RS15605	COG2022	thiamine diphosphate biosynthetic process
LNP58_RS15755	COG3118	belongs to the thioredoxin family
LNP58_RS15780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LNP58_RS15805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LNP58_RS15830	COG2968	Membrane
LNP58_RS15845	COG3164	Protein of unknown function
LNP58_RS15855	COG0312	modulator of DNA gyrase
LNP58_RS15860	COG3028	Belongs to the UPF0307 family
LNP58_RS15865	COG0312	modulator of DNA gyrase
LNP58_RS15890	COG0142	geranyltranstransferase activity
LNP58_RS15895	COG1722	exodeoxyribonuclease VII activity
LNP58_RS15900	COG0037	tRNA processing
LNP58_RS15905	COG1785	Belongs to the alkaline phosphatase family
LNP58_RS15930	COG0791	NLP P60 protein
LNP58_RS15935	COG0791	NLP P60 protein
LNP58_RS15940	COG1047	Peptidyl-prolyl cis-trans
LNP58_RS15945	COG2311	Membrane
LNP58_RS15950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LNP58_RS15990	COG0489	protein tyrosine kinase activity
LNP58_RS15995	COG0717	Belongs to the dCTP deaminase family
LNP58_RS16025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LNP58_RS16070	COG2890	protein-(glutamine-N5) methyltransferase activity
LNP58_RS16075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LNP58_RS16080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LNP58_RS16085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LNP58_RS16105	COG0101	tRNA pseudouridine synthase activity
LNP58_RS16110	COG0135	phosphoribosylanthranilate isomerase activity
LNP58_RS16120	COG0133	tryptophan synthase activity
LNP58_RS16135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LNP58_RS16140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LNP58_RS16190	COG0149	triose-phosphate isomerase activity
LNP58_RS16205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LNP58_RS16215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LNP58_RS16220	COG0649	NAD binding
LNP58_RS16225	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LNP58_RS16230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LNP58_RS16235	COG1034	ATP synthesis coupled electron transport
LNP58_RS16240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LNP58_RS16270	COG1007	ATP synthesis coupled electron transport
LNP58_RS16280	COG0779	Required for maturation of 30S ribosomal subunits
LNP58_RS16285	COG0195	Participates in both transcription termination and antitermination
LNP58_RS16305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LNP58_RS16310	COG1185	polyribonucleotide nucleotidyltransferase activity
LNP58_RS16345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LNP58_RS16355	COG2095	MarC family integral membrane protein
LNP58_RS16370	COG1611	Belongs to the LOG family
LNP58_RS16410	COG4969	Belongs to the N-Me-Phe pilin family
LNP58_RS16415	COG0556	nucleotide-excision repair
LNP58_RS16450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LNP58_RS16520	COG0438	transferase activity, transferring glycosyl groups
LNP58_RS16525	COG0438	transferase activity, transferring glycosyl groups
LNP58_RS16535	COG0438	transferase activity, transferring glycosyl groups
LNP58_RS16575	COG3040	lipid binding
LNP58_RS16660	COG4191	Histidine kinase
LNP58_RS16660	COG0784	Response regulator, receiver
LNP58_RS16680	COG0552	protein localization to endoplasmic reticulum
LNP58_RS16690	COG3938	Belongs to the proline racemase family
LNP58_RS16695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LNP58_RS16710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LNP58_RS16720	COG0006	proline dipeptidase activity
LNP58_RS16735	COG0531	amino acid
LNP58_RS16765	COG4206	TonB-dependent receptor
LNP58_RS16855	COG0746	molybdenum cofactor guanylyltransferase activity
LNP58_RS16885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LNP58_RS16885	COG1648	precorrin-2 dehydrogenase activity
LNP58_RS16920	COG3039	Transposase
LNP58_RS16925	COG3039	Transposase
LNP58_RS16960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LNP58_RS16980	COG3039	Transposase
LNP58_RS16985	COG1054	Belongs to the UPF0176 family
LNP58_RS17000	COG1530	ribonuclease E activity
LNP58_RS17010	COG3064	Membrane
LNP58_RS17025	COG2154	pterin-4-alpha-carbinolamine dehydratase
LNP58_RS17030	COG0316	Belongs to the HesB IscA family
LNP58_RS17030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LNP58_RS17080	COG3039	Transposase
LNP58_RS17095	COG3039	Transposase
LNP58_RS17200	COG0631	protein serine/threonine phosphatase activity
LNP58_RS17205	COG0515	serine threonine protein kinase
LNP58_RS17240	COG1858	cytochrome C peroxidase
LNP58_RS17295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LNP58_RS17365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LNP58_RS17385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LNP58_RS17400	COG1595	DNA-templated transcription, initiation
LNP58_RS17450	COG2244	polysaccharide biosynthetic process
LNP58_RS17480	COG2264	protein methyltransferase activity
LNP58_RS17490	COG0438	transferase activity, transferring glycosyl groups
LNP58_RS17510	COG1136	(ABC) transporter
LNP58_RS17515	COG1132	(ABC) transporter
LNP58_RS17525	COG0477	Major facilitator Superfamily
LNP58_RS17535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LNP58_RS17550	COG1253	flavin adenine dinucleotide binding
LNP58_RS17560	COG0306	phosphate transporter
LNP58_RS17565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LNP58_RS17590	COG0504	CTP synthase activity
LNP58_RS17595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LNP58_RS17605	COG0148	phosphopyruvate hydratase activity
LNP58_RS17610	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LNP58_RS17625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LNP58_RS17635	COG2840	Smr protein MutS2
LNP58_RS17640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LNP58_RS17645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LNP58_RS17650	COG1238	metal cluster binding
LNP58_RS17665	COG1534	Rna-binding protein
LNP58_RS17670	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LNP58_RS17680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LNP58_RS17695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LNP58_RS17700	COG1546	Belongs to the CinA family
LNP58_RS17715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LNP58_RS17720	COG2137	regulation of response to DNA damage stimulus
LNP58_RS17725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LNP58_RS17730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LNP58_RS17750	COG0305	Participates in initiation and elongation during chromosome replication
LNP58_RS17755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LNP58_RS17770	COG1741	Belongs to the pirin family
LNP58_RS17775	COG0583	DNA-binding transcription factor activity
LNP58_RS17800	COG0351	phosphomethylpyrimidine kinase
LNP58_RS17810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LNP58_RS17815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LNP58_RS17830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LNP58_RS17840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LNP58_RS17845	COG3734	2-keto-3-deoxy-galactonokinase
LNP58_RS17855	COG4948	Mandelate Racemase Muconate Lactonizing
LNP58_RS17860	COG0800	Aldolase
LNP58_RS17875	COG1501	Belongs to the glycosyl hydrolase 31 family
LNP58_RS17885	COG1070	Carbohydrate kinase
LNP58_RS17895	COG0477	Major facilitator Superfamily
LNP58_RS17915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LNP58_RS17960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LNP58_RS17965	COG2258	MOSC domain
LNP58_RS17975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LNP58_RS17980	COG0505	Belongs to the CarA family
LNP58_RS17990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LNP58_RS17995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LNP58_RS18005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LNP58_RS18065	COG0784	Response regulator, receiver
LNP58_RS18065	COG2198	Histidine kinase
LNP58_RS18065	COG2205	protein histidine kinase activity
LNP58_RS18070	COG1024	Enoyl-CoA hydratase
LNP58_RS18075	COG0318	PFAM AMP-dependent synthetase and ligase
LNP58_RS18105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LNP58_RS18135	COG0840	transmembrane signaling receptor activity
LNP58_RS18155	COG0835	chemotaxis
LNP58_RS18170	COG0840	transmembrane signaling receptor activity
LNP58_RS18175	COG0840	transmembrane signaling receptor activity
LNP58_RS18180	COG0840	transmembrane signaling receptor activity
LNP58_RS18185	COG0840	transmembrane signaling receptor activity
LNP58_RS18195	COG0840	transmembrane signaling receptor activity
LNP58_RS18205	COG0840	transmembrane signaling receptor activity
LNP58_RS18235	COG0745	RESPONSE REGULATOR receiver
LNP58_RS18245	COG0835	chemotaxis
LNP58_RS18255	COG1360	Flagellar Motor Protein
LNP58_RS18260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LNP58_RS18280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LNP58_RS18290	COG4771	TonB-dependent receptor
LNP58_RS18315	COG3039	Transposase
LNP58_RS18360	COG3501	Rhs element vgr protein
LNP58_RS18360	COG3409	Peptidoglycan-binding domain 1 protein
LNP58_RS18425	COG3039	Transposase
LNP58_RS18440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LNP58_RS18440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LNP58_RS18445	COG1105	Belongs to the carbohydrate kinase PfkB family
LNP58_RS18450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LNP58_RS18450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LNP58_RS18455	COG1609	Transcriptional regulator
LNP58_RS18475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LNP58_RS18480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LNP58_RS18490	COG2902	Dehydrogenase
LNP58_RS18495	COG3039	Transposase
LNP58_RS18505	COG0784	Response regulator, receiver
LNP58_RS18505	COG2205	protein histidine kinase activity
LNP58_RS18505	COG5002	protein histidine kinase activity
LNP58_RS18510	COG2733	membrane
LNP58_RS18520	COG1121	(ABC) transporter
LNP58_RS18525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LNP58_RS18530	COG2223	nitrite transmembrane transporter activity
LNP58_RS18540	COG0243	molybdopterin cofactor binding
LNP58_RS18550	COG0477	Major facilitator Superfamily
LNP58_RS18560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LNP58_RS18565	COG0174	glutamine synthetase
LNP58_RS18600	COG3842	ATPase activity
LNP58_RS18620	COG1012	belongs to the aldehyde dehydrogenase family
LNP58_RS18635	COG4535	Mg2 and Co2 transporter CorC
LNP58_RS18655	COG1702	phosphate starvation-inducible protein PhoH
LNP58_RS18685	COG0741	lytic transglycosylase activity
LNP58_RS18690	COG0723	plastoquinol--plastocyanin reductase activity
LNP58_RS18695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LNP58_RS18700	COG2857	Cytochrome c1
LNP58_RS18705	COG0625	glutathione transferase activity
LNP58_RS18710	COG2969	positive regulation of protein catabolic process
LNP58_RS18735	COG2094	Belongs to the DNA glycosylase MPG family
LNP58_RS18745	COG3328	transposase activity
LNP58_RS18810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LNP58_RS18835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LNP58_RS18840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LNP58_RS18840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LNP58_RS18845	COG0802	atpase or kinase
LNP58_RS18850	COG0860	N-Acetylmuramoyl-L-alanine amidase
LNP58_RS18855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LNP58_RS18875	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS18895	COG2081	HI0933 family
LNP58_RS18900	COG4681	YaeQ
LNP58_RS18905	COG1671	Belongs to the UPF0178 family
LNP58_RS18915	COG0625	glutathione transferase activity
LNP58_RS18935	COG0513	Belongs to the DEAD box helicase family
LNP58_RS18940	COG0488	(ABC) transporter
LNP58_RS18960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LNP58_RS18965	COG0483	inositol monophosphate 1-phosphatase activity
LNP58_RS18980	COG3300	MHYT domain
LNP58_RS18980	COG5001	Diguanylate cyclase
LNP58_RS18985	COG1509	lysine 2,3-aminomutase activity
LNP58_RS19000	COG0402	S-adenosylhomocysteine deaminase activity
LNP58_RS19005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LNP58_RS19030	COG4677	pectinesterase activity
LNP58_RS19040	COG3039	Transposase
LNP58_RS19075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LNP58_RS19100	COG2166	iron-sulfur cluster assembly
LNP58_RS19115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LNP58_RS19120	COG0137	argininosuccinate synthase activity
LNP58_RS19130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LNP58_RS19135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LNP58_RS19150	COG0165	Argininosuccinate lyase
LNP58_RS19170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LNP58_RS19205	COG4988	ABC transporter
LNP58_RS19210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LNP58_RS19285	COG3039	Transposase
LNP58_RS19295	COG3039	Transposase
LNP58_RS19305	COG3209	COG3209 Rhs family protein
LNP58_RS19315	COG3039	Transposase
LNP58_RS19345	COG0643	Histidine kinase
LNP58_RS19345	COG2198	Histidine kinase
LNP58_RS19345	COG0784	Response regulator, receiver
LNP58_RS19400	COG1684	flagellar biosynthetic protein fliR
LNP58_RS19415	COG3190	flagellar
LNP58_RS19465	COG1677	Flagellar hook-basal body complex protein FliE
LNP58_RS19495	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS19505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LNP58_RS19525	COG2201	protein-glutamate methylesterase activity
LNP58_RS19560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LNP58_RS19565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LNP58_RS19600	COG4787	bacterial-type flagellum-dependent cell motility
LNP58_RS19610	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LNP58_RS19615	COG1558	bacterial-type flagellum-dependent cell motility
LNP58_RS19625	COG0835	chemotaxis
LNP58_RS19625	COG0784	Response regulator, receiver
LNP58_RS19645	COG5002	protein histidine kinase activity
LNP58_RS19655	COG4585	Histidine kinase
LNP58_RS19660	COG5001	Diguanylate cyclase
LNP58_RS19685	COG0482	sulfurtransferase activity
LNP58_RS19700	COG0542	response to heat
LNP58_RS19735	COG0492	ferredoxin-NADP+ reductase activity
LNP58_RS19740	COG1674	ftsk spoiiie
LNP58_RS19760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LNP58_RS19780	COG0038	chloride channel
LNP58_RS19785	COG0183	Belongs to the thiolase family
LNP58_RS19790	COG1024	Enoyl-CoA hydratase
LNP58_RS19790	COG1250	3-hydroxyacyl-CoA dehydrogenase
LNP58_RS19805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LNP58_RS19815	COG1426	Protein conserved in bacteria
LNP58_RS19825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LNP58_RS19835	COG0303	'Molybdopterin
LNP58_RS19870	COG3039	Transposase
LNP58_RS19905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LNP58_RS19925	COG0742	ribosomal rna small subunit methyltransferase
LNP58_RS19930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LNP58_RS19940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LNP58_RS19945	COG0405	Gamma-glutamyltransferase
LNP58_RS20020	COG0343	queuine tRNA-ribosyltransferase activity
LNP58_RS20025	COG1862	Preprotein translocase
LNP58_RS20030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LNP58_RS20035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LNP58_RS20045	COG3039	Transposase
LNP58_RS20080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LNP58_RS20090	COG0704	Plays a role in the regulation of phosphate uptake
LNP58_RS20105	COG0573	inorganic phosphate transmembrane transporter activity
LNP58_RS20110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LNP58_RS20150	COG3039	Transposase
LNP58_RS20170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LNP58_RS20180	COG1024	Enoyl-CoA hydratase
LNP58_RS20195	COG0494	nUDIX hydrolase
LNP58_RS20240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LNP58_RS20240	COG0116	Belongs to the methyltransferase superfamily
LNP58_RS20265	COG0667	Aldo Keto reductase
LNP58_RS20275	COG2925	Exonuclease
LNP58_RS20300	COG0288	reversible hydration of carbon dioxide
LNP58_RS20330	COG0316	Belongs to the HesB IscA family
LNP58_RS20335	COG0360	Binds together with S18 to 16S ribosomal RNA
LNP58_RS20345	COG0359	binds to the 23S rRNA
LNP58_RS20355	COG3115	cell septum assembly
LNP58_RS20375	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LNP58_RS20390	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LNP58_RS20415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LNP58_RS20425	COG2986	histidine ammonia-lyase
LNP58_RS20430	COG1228	amidohydrolase
LNP58_RS20470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LNP58_RS20480	COG0077	Prephenate dehydratase
LNP58_RS20480	COG1605	Chorismate mutase
LNP58_RS20485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LNP58_RS20515	COG4566	intracellular signal transduction
LNP58_RS20560	COG0860	N-Acetylmuramoyl-L-alanine amidase
LNP58_RS20565	COG1469	GTP cyclohydrolase I activity
LNP58_RS20575	COG0617	tRNA 3'-terminal CCA addition
LNP58_RS20590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LNP58_RS20620	COG1472	Belongs to the glycosyl hydrolase 3 family
LNP58_RS20635	COG2203	Gaf domain
LNP58_RS20635	COG3706	GGDEF domain
LNP58_RS20635	COG4251	negative regulation of phosphorylation
LNP58_RS20635	COG5001	Diguanylate cyclase
LNP58_RS20720	COG0386	Belongs to the glutathione peroxidase family
LNP58_RS20795	COG5002	protein histidine kinase activity
LNP58_RS20795	COG2205	protein histidine kinase activity
LNP58_RS20795	COG0784	Response regulator, receiver
LNP58_RS20825	COG0800	Aldolase
LNP58_RS20830	COG0129	dihydroxy-acid dehydratase activity
LNP58_RS20835	COG0363	glucosamine-6-phosphate deaminase activity
LNP58_RS20845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LNP58_RS20860	COG0354	folic acid binding
LNP58_RS20875	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LNP58_RS20890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LNP58_RS20905	COG4591	ABC-type transport system involved in lipoprotein release permease component
LNP58_RS20930	COG0811	peptide transport
LNP58_RS20945	COG1663	tetraacyldisaccharide 4'-kinase activity
LNP58_RS20955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LNP58_RS20965	COG0322	excinuclease ABC activity
LNP58_RS21000	COG3328	transposase activity
LNP58_RS21015	COG2201	protein-glutamate methylesterase activity
LNP58_RS21245	COG0140	phosphoribosyl-ATP diphosphatase activity
LNP58_RS21245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LNP58_RS21255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LNP58_RS21265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LNP58_RS21265	COG0131	Imidazoleglycerol-phosphate dehydratase
LNP58_RS21280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LNP58_RS21300	COG0124	histidyl-tRNA synthetase
LNP58_RS21315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LNP58_RS21350	COG1012	belongs to the aldehyde dehydrogenase family
LNP58_RS21380	COG0697	spore germination
LNP58_RS21405	COG0671	phosphoesterase, PA-phosphatase related
LNP58_RS21420	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LNP58_RS21435	COG2183	response to ionizing radiation
LNP58_RS21445	COG0723	plastoquinol--plastocyanin reductase activity
LNP58_RS21445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LNP58_RS21460	COG3243	poly(R)-hydroxyalkanoic acid synthase
LNP58_RS21470	COG1183	phosphatidylcholine synthase activity
LNP58_RS21475	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS21525	COG0668	transmembrane transport
LNP58_RS21545	COG1914	H( )-stimulated, divalent metal cation uptake system
LNP58_RS21580	COG1028	Short-chain dehydrogenase reductase Sdr
LNP58_RS21595	COG0583	DNA-binding transcription factor activity
LNP58_RS21600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LNP58_RS21605	COG3002	Belongs to the UPF0753 family
LNP58_RS21620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LNP58_RS21640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LNP58_RS21650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LNP58_RS21655	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LNP58_RS21665	COG0776	regulation of translation
LNP58_RS21670	COG0539	negative regulation of cytoplasmic translation
LNP58_RS21675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LNP58_RS21690	COG2957	Belongs to the agmatine deiminase family
LNP58_RS21700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LNP58_RS21725	COG0395	ABC-type sugar transport system, permease component
LNP58_RS21730	COG1175	transmembrane transport
LNP58_RS21760	COG2350	Protein conserved in bacteria
LNP58_RS21765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LNP58_RS21770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LNP58_RS21775	COG1187	pseudouridine synthase activity
LNP58_RS21800	COG0436	Aminotransferase
LNP58_RS21865	COG0277	FAD linked oxidase domain protein
LNP58_RS21870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LNP58_RS21880	COG0531	amino acid
LNP58_RS21885	COG0531	amino acid
LNP58_RS21895	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LNP58_RS21925	COG2201	protein-glutamate methylesterase activity
LNP58_RS21975	COG0583	DNA-binding transcription factor activity
LNP58_RS21985	COG3039	Transposase
LNP58_RS22035	COG3039	Transposase
LNP58_RS22085	COG3039	Transposase
LNP58_RS22095	COG3039	Transposase
LNP58_RS22120	COG3328	transposase activity
LNP58_RS22140	COG3039	Transposase
LNP58_RS22150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LNP58_RS22170	COG0557	exoribonuclease II activity
LNP58_RS22195	COG1960	acyl-CoA dehydrogenase activity
LNP58_RS22200	COG2226	methyltransferase
LNP58_RS22205	COG0646	methionine synthase
LNP58_RS22205	COG1410	methionine synthase
LNP58_RS22210	COG1410	methionine synthase
LNP58_RS22210	COG0646	methionine synthase
LNP58_RS22220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LNP58_RS22230	COG1609	Transcriptional regulator
LNP58_RS22245	COG2900	Belongs to the SlyX family
LNP58_RS22260	COG0386	Belongs to the glutathione peroxidase family
LNP58_RS22270	COG1725	Transcriptional regulator
LNP58_RS22275	COG1131	(ABC) transporter
LNP58_RS22350	COG2850	peptidyl-arginine hydroxylation
LNP58_RS22385	COG1132	(ABC) transporter
LNP58_RS22410	COG1605	Chorismate mutase
LNP58_RS22410	COG0287	Prephenate dehydrogenase
LNP58_RS22415	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LNP58_RS22420	COG0484	heat shock protein binding
LNP58_RS22425	COG0443	Heat shock 70 kDa protein
LNP58_RS22430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LNP58_RS22440	COG0497	DNA recombination
LNP58_RS22450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LNP58_RS22455	COG2914	Belongs to the UPF0125 (RnfH) family
LNP58_RS22480	COG1960	acyl-CoA dehydrogenase activity
LNP58_RS22490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LNP58_RS22535	COG2814	Major facilitator Superfamily
LNP58_RS22540	COG1566	PFAM secretion protein HlyD family protein
LNP58_RS22575	COG4774	siderophore transport
LNP58_RS22585	COG0367	asparagine synthase
LNP58_RS22600	COG1393	Belongs to the ArsC family
LNP58_RS22660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LNP58_RS22675	COG0233	cytoplasmic translational termination
LNP58_RS22685	COG0575	Belongs to the CDS family
LNP58_RS22695	COG0750	zinc metalloprotease
LNP58_RS22715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LNP58_RS22720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LNP58_RS22740	COG0825	malonyl-CoA metabolic process
LNP58_RS22750	COG4771	TonB-dependent receptor
LNP58_RS22755	COG1131	(ABC) transporter
LNP58_RS22780	COG1981	membrane
LNP58_RS22825	COG2895	sulfate adenylyltransferase (ATP) activity
LNP58_RS22825	COG0529	Catalyzes the synthesis of activated sulfate
LNP58_RS22860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LNP58_RS22875	COG2040	homocysteine
LNP58_RS22880	COG0833	amino acid
LNP58_RS22900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LNP58_RS22900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LNP58_RS22910	COG2878	Part of a membrane complex involved in electron transport
LNP58_RS22925	COG1595	DNA-templated transcription, initiation
LNP58_RS22950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LNP58_RS22965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LNP58_RS22970	COG0251	oxidation-reduction process
LNP58_RS22980	COG0392	lysyltransferase activity
LNP58_RS22980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LNP58_RS23025	COG2814	Major facilitator Superfamily
LNP58_RS23030	COG1902	pentaerythritol trinitrate reductase activity
LNP58_RS23040	COG2824	Alkylphosphonate utilization operon protein PhnA
LNP58_RS23055	COG1047	Peptidyl-prolyl cis-trans
LNP58_RS23090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LNP58_RS23130	COG0183	Belongs to the thiolase family
LNP58_RS23160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LNP58_RS23160	COG1793	dna ligase
LNP58_RS23170	COG1793	dna ligase
LNP58_RS23175	COG1201	RNA secondary structure unwinding
LNP58_RS23205	COG1278	Cold shock
LNP58_RS23210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LNP58_RS23215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LNP58_RS23225	COG3046	protein related to deoxyribodipyrimidine photolyase
LNP58_RS23230	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LNP58_RS23235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LNP58_RS23250	COG2954	triphosphatase activity
LNP58_RS23265	COG1381	Involved in DNA repair and RecF pathway recombination
LNP58_RS23295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LNP58_RS23310	COG1250	3-hydroxyacyl-CoA dehydrogenase
LNP58_RS23310	COG1024	Enoyl-CoA hydratase
LNP58_RS23330	COG1024	Enoyl-CoA hydratase
LNP58_RS23335	COG1960	acyl-CoA dehydrogenase activity