locus-tag	class	description
BRM60_RS00030	COG0187	DNA topoisomerase II activity
BRM60_RS00040	COG0501	Belongs to the peptidase M48B family
BRM60_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM60_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRM60_RS00100	COG4772	TonB-dependent receptor
BRM60_RS00115	COG3039	Transposase
BRM60_RS00120	COG1304	FMN binding
BRM60_RS00125	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRM60_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM60_RS00160	COG3039	Transposase
BRM60_RS00170	COG3039	Transposase
BRM60_RS00175	COG1116	anion transmembrane transporter activity
BRM60_RS00225	COG3039	Transposase
BRM60_RS00235	COG0513	Belongs to the DEAD box helicase family
BRM60_RS00290	COG3039	Transposase
BRM60_RS00340	COG1858	cytochrome C peroxidase
BRM60_RS00350	COG0702	epimerase
BRM60_RS00375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRM60_RS00395	COG1649	PFAM Uncharacterised BCR, COG1649
BRM60_RS00400	COG2354	Protein conserved in bacteria
BRM60_RS00410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM60_RS00425	COG3264	Mechanosensitive ion channel
BRM60_RS00425	COG1511	domain protein
BRM60_RS00505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRM60_RS00610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM60_RS00620	COG0642	Histidine kinase
BRM60_RS00630	COG1090	epimerase
BRM60_RS00640	COG3039	Transposase
BRM60_RS00665	COG2826	transposase and inactivated derivatives, IS30 family
BRM60_RS00720	COG1136	(ABC) transporter
BRM60_RS00765	COG1272	protein, Hemolysin III
BRM60_RS00770	COG1205	dead DEAH box helicase
BRM60_RS00770	COG1111	helicase
BRM60_RS00830	COG0069	glutamate synthase activity
BRM60_RS00830	COG0067	glutamate synthase
BRM60_RS00830	COG0070	glutamate synthase
BRM60_RS00835	COG0493	'glutamate synthase
BRM60_RS00885	COG1609	Transcriptional regulator
BRM60_RS00920	COG0366	Alpha amylase catalytic
BRM60_RS00925	COG0366	Alpha amylase catalytic
BRM60_RS00980	COG0606	chelatase, subunit chli
BRM60_RS01025	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRM60_RS01030	COG1166	arginine decarboxylase activity
BRM60_RS01095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM60_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS01145	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRM60_RS01160	COG0210	DNA helicase
BRM60_RS01175	COG3132	Protein of unknown function, DUF480
BRM60_RS01180	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRM60_RS01185	COG0284	orotidine-5'-phosphate decarboxylase activity
BRM60_RS01220	COG2937	Belongs to the GPAT DAPAT family
BRM60_RS01250	COG2755	lipolytic protein G-D-S-L family
BRM60_RS01265	COG3186	Phenylalanine-4-hydroxylase
BRM60_RS01270	COG1522	sequence-specific DNA binding
BRM60_RS01320	COG1064	alcohol dehydrogenase
BRM60_RS01330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM60_RS01340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM60_RS01350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM60_RS01375	COG3039	Transposase
BRM60_RS01380	COG0676	glucose-6-phosphate 1-epimerase activity
BRM60_RS01445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRM60_RS01470	COG2853	Lipoprotein
BRM60_RS01485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM60_RS01490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM60_RS01495	COG1127	ABC transporter
BRM60_RS01570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM60_RS01580	COG3265	gluconokinase activity
BRM60_RS01585	COG2211	Major facilitator Superfamily
BRM60_RS01590	COG3459	Glycosyltransferase 36 associated
BRM60_RS01605	COG2205	protein histidine kinase activity
BRM60_RS01615	COG1414	Transcriptional regulator
BRM60_RS01620	COG0738	Major facilitator superfamily
BRM60_RS01625	COG3254	rhamnose metabolic process
BRM60_RS01655	COG0339	signal peptide processing
BRM60_RS01685	COG0564	pseudouridine synthase activity
BRM60_RS01695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM60_RS01795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRM60_RS01805	COG0842	Transport permease protein
BRM60_RS01810	COG1131	(ABC) transporter
BRM60_RS01815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM60_RS01835	COG1476	TRANSCRIPTIONal
BRM60_RS01845	COG4555	ABC transporter
BRM60_RS01880	COG0625	glutathione transferase activity
BRM60_RS01930	COG0583	DNA-binding transcription factor activity
BRM60_RS01965	COG1199	ATP-dependent helicase activity
BRM60_RS01985	COG1566	PFAM secretion protein HlyD family protein
BRM60_RS02015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM60_RS02055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRM60_RS02055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRM60_RS02060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRM60_RS02075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRM60_RS02115	COG3237	CsbD-like
BRM60_RS02120	COG0180	Tryptophanyl-tRNA synthetase
BRM60_RS02125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM60_RS02175	COG0753	catalase activity
BRM60_RS02180	COG1595	DNA-templated transcription, initiation
BRM60_RS02190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM60_RS02200	COG0628	permease
BRM60_RS02215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRM60_RS02220	COG1040	competence protein
BRM60_RS02225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRM60_RS02230	COG0156	8-amino-7-oxononanoate synthase activity
BRM60_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS02260	COG0463	Glycosyl transferase, family 2
BRM60_RS02270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRM60_RS02275	COG3100	YcgL domain-containing protein
BRM60_RS02295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM60_RS02315	COG2239	Acts as a magnesium transporter
BRM60_RS02325	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM60_RS02325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRM60_RS02325	COG1042	CoA-binding domain protein
BRM60_RS02335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM60_RS02345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM60_RS02380	COG3485	protocatechuate 3,4-dioxygenase
BRM60_RS02385	COG3485	protocatechuate 3,4-dioxygenase
BRM60_RS02395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BRM60_RS02400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM60_RS02405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRM60_RS02430	COG4221	oxidoreductase activity
BRM60_RS02445	COG0018	arginyl-trna synthetase
BRM60_RS02450	COG2003	Belongs to the UPF0758 family
BRM60_RS02455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRM60_RS02480	COG0463	Glycosyl transferase, family 2
BRM60_RS02495	COG1475	DNA binding
BRM60_RS02500	COG1192	Involved in chromosome partitioning
BRM60_RS02515	COG0708	Exodeoxyribonuclease III
BRM60_RS02520	COG2211	Major facilitator Superfamily
BRM60_RS02535	COG0739	heme binding
BRM60_RS02580	COG0745	RESPONSE REGULATOR receiver
BRM60_RS02625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRM60_RS02650	COG2814	Major facilitator Superfamily
BRM60_RS02665	COG1289	transmembrane transporter activity
BRM60_RS02675	COG1136	(ABC) transporter
BRM60_RS02675	COG0577	efflux transmembrane transporter activity
BRM60_RS02680	COG0151	Belongs to the GarS family
BRM60_RS02690	COG0419	ATPase involved in DNA repair
BRM60_RS02705	COG2267	carboxylic ester hydrolase activity
BRM60_RS02715	COG2267	carboxylic ester hydrolase activity
BRM60_RS02720	COG2453	phosphatase
BRM60_RS02720	COG0671	phosphoesterase, PA-phosphatase related
BRM60_RS02735	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRM60_RS02795	COG0439	Biotin carboxylase
BRM60_RS02805	COG0511	ligase activity, forming carbon-carbon bonds
BRM60_RS02810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRM60_RS02830	COG1324	tolerance protein
BRM60_RS02865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRM60_RS02895	COG0534	Mate efflux family protein
BRM60_RS02900	COG0616	signal peptide processing
BRM60_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS02925	COG0009	L-threonylcarbamoyladenylate synthase
BRM60_RS02930	COG1754	DNA topoisomerase type I activity
BRM60_RS02930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRM60_RS02945	COG2922	Belongs to the Smg family
BRM60_RS02950	COG0758	DNA mediated transformation
BRM60_RS02955	COG1652	LysM domain
BRM60_RS02960	COG0242	peptide deformylase activity
BRM60_RS02965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRM60_RS02970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM60_RS02970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRM60_RS03020	COG1560	Kdo2-lipid A biosynthetic process
BRM60_RS03030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM60_RS03275	COG1294	oxidase, subunit
BRM60_RS03280	COG1271	oxidase subunit
BRM60_RS03295	COG2204	response regulator
BRM60_RS03325	COG2972	Histidine kinase
BRM60_RS03340	COG0531	amino acid
BRM60_RS03360	COG3590	peptidase
BRM60_RS03375	COG0667	Aldo Keto reductase
BRM60_RS03390	COG3384	dioxygenase
BRM60_RS03400	COG1573	uracil-dna glycosylase
BRM60_RS03410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRM60_RS03425	COG0025	NhaP-type Na H and K H
BRM60_RS03430	COG1131	(ABC) transporter
BRM60_RS03435	COG0842	Transport permease protein
BRM60_RS03455	COG1404	Belongs to the peptidase S8 family
BRM60_RS03470	COG0745	RESPONSE REGULATOR receiver
BRM60_RS03520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM60_RS03545	COG2202	Pas domain
BRM60_RS03545	COG2205	protein histidine kinase activity
BRM60_RS03580	COG2813	Specifically methylates the guanine in position
BRM60_RS03585	COG1187	pseudouridine synthase activity
BRM60_RS03590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRM60_RS03625	COG0697	spore germination
BRM60_RS03635	COG2011	ABC-type metal ion transport system permease component
BRM60_RS03665	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRM60_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRM60_RS03695	COG0356	it plays a direct role in the translocation of protons across the membrane
BRM60_RS03705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRM60_RS03715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRM60_RS03720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRM60_RS03725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRM60_RS03730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BRM60_RS03785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM60_RS03790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM60_RS03855	COG0339	signal peptide processing
BRM60_RS03895	COG1956	GAF domain-containing protein
BRM60_RS03900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRM60_RS03910	COG0720	synthase
BRM60_RS03920	COG0513	Belongs to the DEAD box helicase family
BRM60_RS03965	COG0626	cystathionine gamma-synthase activity
BRM60_RS04015	COG3328	transposase activity
BRM60_RS04040	COG2086	electron transfer activity
BRM60_RS04065	COG0662	Cupin 2, conserved barrel domain protein
BRM60_RS04065	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRM60_RS04070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM60_RS04110	COG3218	ABC-type transport auxiliary lipoprotein component
BRM60_RS04110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM60_RS04115	COG1127	ABC transporter
BRM60_RS04120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM60_RS04135	COG0442	prolyl-tRNA aminoacylation
BRM60_RS04145	COG1183	phosphatidylcholine synthase activity
BRM60_RS04175	COG3039	Transposase
BRM60_RS04245	COG0525	valine-tRNA ligase activity
BRM60_RS04260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM60_RS04270	COG0795	lipopolysaccharide-transporting ATPase activity
BRM60_RS04285	COG4974	Belongs to the 'phage' integrase family
BRM60_RS04290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRM60_RS04295	COG0047	phosphoribosylformylglycinamidine synthase activity
BRM60_RS04295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRM60_RS04305	COG5295	Hep Hag repeat protein
BRM60_RS04325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM60_RS04335	COG1459	type II secretion system
BRM60_RS04340	COG2165	general secretion pathway protein
BRM60_RS04345	COG4970	Tfp pilus assembly protein FimT
BRM60_RS04350	COG2165	general secretion pathway protein
BRM60_RS04355	COG4795	General secretion pathway protein
BRM60_RS04360	COG3156	type II secretion system protein K
BRM60_RS04365	COG3166	PFAM Fimbrial assembly family protein
BRM60_RS04380	COG1450	Type ii and iii secretion system protein
BRM60_RS04395	COG2188	Transcriptional regulator
BRM60_RS04450	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRM60_RS04455	COG1518	maintenance of DNA repeat elements
BRM60_RS04500	COG1399	metal-binding, possibly nucleic acid-binding protein
BRM60_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS04530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM60_RS04540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRM60_RS04545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRM60_RS04570	COG3829	transcription factor binding
BRM60_RS04605	COG3039	Transposase
BRM60_RS04655	COG2826	transposase and inactivated derivatives, IS30 family
BRM60_RS04665	COG0678	peroxiredoxin activity
BRM60_RS04685	COG0330	HflC and HflK could
BRM60_RS04690	COG0330	HflC and HflK could
BRM60_RS04705	COG0308	aminopeptidase N
BRM60_RS04745	COG3039	Transposase
BRM60_RS04765	COG1560	Kdo2-lipid A biosynthetic process
BRM60_RS04770	COG1519	Transferase
BRM60_RS04775	COG1538	Outer membrane efflux protein
BRM60_RS04780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM60_RS04805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRM60_RS04810	COG0066	3-isopropylmalate dehydratase activity
BRM60_RS04845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRM60_RS04855	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRM60_RS04860	COG3710	Transcriptional regulator
BRM60_RS04885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRM60_RS04905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRM60_RS04935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM60_RS04945	COG3781	membrane
BRM60_RS04965	COG0625	glutathione transferase activity
BRM60_RS04975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRM60_RS04980	COG1217	gtp-binding protein TYPA
BRM60_RS05000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRM60_RS05135	COG3039	Transposase
BRM60_RS05160	COG0584	glycerophosphoryl diester phosphodiesterase
BRM60_RS05185	COG0473	3-isopropylmalate dehydrogenase activity
BRM60_RS05240	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRM60_RS05280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRM60_RS05305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM60_RS05315	COG0631	protein serine/threonine phosphatase activity
BRM60_RS05385	COG0582	viral genome integration into host DNA
BRM60_RS05395	COG0859	PFAM glycosyl transferase family 9
BRM60_RS05400	COG3642	lipopolysaccharide core region biosynthetic process
BRM60_RS05405	COG1234	tRNA 3'-trailer cleavage
BRM60_RS05410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRM60_RS05420	COG0315	cyclic pyranopterin monophosphate synthase activity
BRM60_RS05425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRM60_RS05430	COG0314	molybdopterin synthase activity
BRM60_RS05460	COG0537	adenosine 5'-monophosphoramidase activity
BRM60_RS05480	COG0714	Associated with various cellular activities
BRM60_RS05500	COG0242	peptide deformylase activity
BRM60_RS05550	COG3039	Transposase
BRM60_RS05580	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM60_RS05585	COG0726	polysaccharide deacetylase
BRM60_RS05635	COG2211	Major facilitator Superfamily
BRM60_RS05645	COG1609	Transcriptional regulator
BRM60_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS05655	COG2851	Citrate transporter
BRM60_RS05675	COG0642	Histidine kinase
BRM60_RS05685	COG2197	response regulator
BRM60_RS05705	COG0583	DNA-binding transcription factor activity
BRM60_RS05720	COG4191	Histidine kinase
BRM60_RS05740	COG0281	malic enzyme
BRM60_RS05740	COG0280	phosphate acetyltransferase
BRM60_RS05775	COG0352	thiamine-phosphate diphosphorylase activity
BRM60_RS05780	COG1773	rubredoxin
BRM60_RS05785	COG2912	Transglutaminase-like superfamily
BRM60_RS05805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRM60_RS05830	COG0006	proline dipeptidase activity
BRM60_RS05865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRM60_RS05880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRM60_RS05885	COG1561	YicC-like family, N-terminal region
BRM60_RS05910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM60_RS05920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRM60_RS05950	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRM60_RS06000	COG0714	Associated with various cellular activities
BRM60_RS06020	COG2304	oxidoreductase activity
BRM60_RS06040	COG1301	dicarboxylic acid transport
BRM60_RS06045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRM60_RS06055	COG0739	heme binding
BRM60_RS06060	COG1376	ErfK ybiS ycfS ynhG family protein
BRM60_RS06085	COG1022	Amp-dependent synthetase and ligase
BRM60_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS06110	COG0642	Histidine kinase
BRM60_RS06130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRM60_RS06135	COG4149	molybdate abc transporter
BRM60_RS06140	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRM60_RS06145	COG3453	Protein conserved in bacteria
BRM60_RS06145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM60_RS06175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRM60_RS06195	COG2205	protein histidine kinase activity
BRM60_RS06200	COG0745	RESPONSE REGULATOR receiver
BRM60_RS06250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM60_RS06255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRM60_RS06300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BRM60_RS06385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BRM60_RS06400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRM60_RS06415	COG1842	Phage shock protein A
BRM60_RS06440	COG0754	glutathionylspermidine amidase activity
BRM60_RS06510	COG0531	amino acid
BRM60_RS06515	COG2197	response regulator
BRM60_RS06530	COG1113	amino acid transport
BRM60_RS06550	COG1271	oxidase subunit
BRM60_RS06555	COG1294	oxidase, subunit
BRM60_RS06565	COG2239	Acts as a magnesium transporter
BRM60_RS06575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM60_RS06580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM60_RS06590	COG1660	Displays ATPase and GTPase activities
BRM60_RS06595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRM60_RS06600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM60_RS06615	COG1137	ATPase activity
BRM60_RS06620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRM60_RS06630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRM60_RS06640	COG0271	Belongs to the BolA IbaG family
BRM60_RS06650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRM60_RS06670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRM60_RS06685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRM60_RS06695	COG0628	permease
BRM60_RS06705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRM60_RS06710	COG3178	'Phosphotransferase
BRM60_RS06725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM60_RS06730	COG1555	photosystem II stabilization
BRM60_RS06780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM60_RS06790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRM60_RS06815	COG0228	four-way junction DNA binding
BRM60_RS06820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRM60_RS06825	COG0336	Belongs to the RNA methyltransferase TrmD family
BRM60_RS06840	COG0534	Mate efflux family protein
BRM60_RS06880	COG0542	response to heat
BRM60_RS06920	COG4206	TonB-dependent receptor
BRM60_RS06980	COG0019	diaminopimelate decarboxylase activity
BRM60_RS06990	COG2814	Major facilitator Superfamily
BRM60_RS06995	COG4264	IucA IucC family
BRM60_RS07005	COG4772	TonB-dependent receptor
BRM60_RS07020	COG4651	solute:proton antiporter activity
BRM60_RS07020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRM60_RS07055	COG0488	(ABC) transporter
BRM60_RS07080	COG0657	acetylesterase activity
BRM60_RS07080	COG2755	lipolytic protein G-D-S-L family
BRM60_RS07100	COG2207	Transcriptional regulator
BRM60_RS07105	COG0326	Molecular chaperone. Has ATPase activity
BRM60_RS07135	COG3328	transposase activity
BRM60_RS07140	COG0174	glutamine synthetase
BRM60_RS07145	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRM60_RS07155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRM60_RS07170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM60_RS07200	COG2146	nitrite reductase [NAD(P)H] activity
BRM60_RS07210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRM60_RS07215	COG0719	Fe-S assembly protein
BRM60_RS07220	COG0396	ATPase activity
BRM60_RS07225	COG0719	Fe-S assembly protein
BRM60_RS07230	COG1959	2 iron, 2 sulfur cluster binding
BRM60_RS07250	COG0693	protein deglycase activity
BRM60_RS07295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRM60_RS07335	COG0519	Catalyzes the synthesis of GMP from XMP
BRM60_RS07345	COG1678	Uncharacterized ACR, COG1678
BRM60_RS07350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRM60_RS07365	COG1764	response to oxidative stress
BRM60_RS07375	COG0384	phenazine biosynthesis protein PhzF
BRM60_RS07385	COG0527	aspartate kinase activity
BRM60_RS07415	COG0142	geranyltranstransferase activity
BRM60_RS07420	COG0629	single-stranded DNA binding
BRM60_RS07425	COG3706	GGDEF domain
BRM60_RS07425	COG4251	negative regulation of phosphorylation
BRM60_RS07425	COG5001	Diguanylate cyclase
BRM60_RS07425	COG2203	Gaf domain
BRM60_RS07465	COG2879	small protein
BRM60_RS07470	COG1966	Carbon starvation protein
BRM60_RS07475	COG1741	Belongs to the pirin family
BRM60_RS07570	COG1741	Belongs to the pirin family
BRM60_RS07580	COG1515	deoxyribonuclease V activity
BRM60_RS07600	COG3590	peptidase
BRM60_RS07615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRM60_RS07620	COG2199	diguanylate cyclase activity
BRM60_RS07620	COG2202	Pas domain
BRM60_RS07620	COG2200	EAL domain
BRM60_RS07625	COG0835	chemotaxis
BRM60_RS07630	COG0840	transmembrane signaling receptor activity
BRM60_RS07635	COG0643	Histidine kinase
BRM60_RS07635	COG2198	Histidine kinase
BRM60_RS07645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRM60_RS07655	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRM60_RS07675	COG2205	protein histidine kinase activity
BRM60_RS07700	COG3039	Transposase
BRM60_RS07725	COG3039	Transposase
BRM60_RS07760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRM60_RS07765	COG0735	belongs to the Fur family
BRM60_RS07825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRM60_RS07830	COG0084	hydrolase, TatD family'
BRM60_RS07845	COG1960	acyl-CoA dehydrogenase activity
BRM60_RS07860	COG0367	asparagine synthase
BRM60_RS07870	COG0305	Participates in initiation and elongation during chromosome replication
BRM60_RS07875	COG0415	Belongs to the DNA photolyase family
BRM60_RS07995	COG5002	protein histidine kinase activity
BRM60_RS07995	COG5001	Diguanylate cyclase
BRM60_RS08000	COG1187	pseudouridine synthase activity
BRM60_RS08025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM60_RS08035	COG0475	glutathione-regulated potassium exporter activity
BRM60_RS08040	COG5000	phosphorelay sensor kinase activity
BRM60_RS08040	COG5002	protein histidine kinase activity
BRM60_RS08045	COG0745	RESPONSE REGULATOR receiver
BRM60_RS08075	COG1132	(ABC) transporter
BRM60_RS08100	COG3039	Transposase
BRM60_RS08115	COG3039	Transposase
BRM60_RS08160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRM60_RS08170	COG4969	Belongs to the N-Me-Phe pilin family
BRM60_RS08175	COG2194	sulfuric ester hydrolase activity
BRM60_RS08215	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM60_RS08220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRM60_RS08235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRM60_RS08235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM60_RS08240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM60_RS08245	COG0564	pseudouridine synthase activity
BRM60_RS08270	COG3387	PFAM Glycoside hydrolase 15-related
BRM60_RS08275	COG1877	trehalose-phosphatase activity
BRM60_RS08315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BRM60_RS08335	COG1595	DNA-templated transcription, initiation
BRM60_RS08345	COG1946	Acyl-CoA thioesterase
BRM60_RS08360	COG0824	Thioesterase
BRM60_RS08365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRM60_RS08375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRM60_RS08380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRM60_RS08385	COG0268	Binds directly to 16S ribosomal RNA
BRM60_RS08390	COG0728	peptidoglycan biosynthetic process
BRM60_RS08395	COG0196	riboflavin kinase activity
BRM60_RS08405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRM60_RS08410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRM60_RS08425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRM60_RS08430	COG1845	cytochrome c oxidase, subunit III
BRM60_RS08435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRM60_RS08455	COG3209	COG3209 Rhs family protein
BRM60_RS08490	COG3209	COG3209 Rhs family protein
BRM60_RS08610	COG0632	four-way junction helicase activity
BRM60_RS08620	COG2255	four-way junction helicase activity
BRM60_RS08625	COG0824	Thioesterase
BRM60_RS08635	COG0848	biopolymer transport protein
BRM60_RS08650	COG2885	chlorophyll binding
BRM60_RS08660	COG0602	queuosine metabolic process
BRM60_RS08670	COG1187	pseudouridine synthase activity
BRM60_RS08730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRM60_RS08755	COG0514	ATP-dependent DNA helicase (RecQ)
BRM60_RS08765	COG0783	Belongs to the Dps family
BRM60_RS08770	COG1643	Atp-dependent helicase
BRM60_RS08825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM60_RS08835	COG1215	transferase activity, transferring glycosyl groups
BRM60_RS08840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRM60_RS08850	COG1199	ATP-dependent helicase activity
BRM60_RS08860	COG1397	ADP-ribosylglycohydrolase
BRM60_RS08870	COG0189	ligase activity
BRM60_RS08885	COG0835	chemotaxis
BRM60_RS08890	COG0840	transmembrane signaling receptor activity
BRM60_RS08895	COG0643	Histidine kinase
BRM60_RS08895	COG0784	Response regulator, receiver
BRM60_RS08895	COG2198	Histidine kinase
BRM60_RS08940	COG1446	asparaginase
BRM60_RS08945	COG3142	Participates in the control of copper homeostasis
BRM60_RS09005	COG3537	Alpha-1,2-mannosidase
BRM60_RS09075	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM60_RS09095	COG3858	chitin binding
BRM60_RS09095	COG1388	LysM domain
BRM60_RS09110	COG0837	glucose binding
BRM60_RS09115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRM60_RS09125	COG0494	nUDIX hydrolase
BRM60_RS09135	COG3956	TIGRFAM MazG family protein
BRM60_RS09150	COG0330	HflC and HflK could
BRM60_RS09165	COG0509	glycine decarboxylation via glycine cleavage system
BRM60_RS09200	COG1960	acyl-CoA dehydrogenase activity
BRM60_RS09210	COG1309	transcriptional regulator
BRM60_RS09215	COG4771	TonB-dependent receptor
BRM60_RS09225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRM60_RS09235	COG0463	Glycosyl transferase, family 2
BRM60_RS09255	COG1272	protein, Hemolysin III
BRM60_RS09265	COG0739	heme binding
BRM60_RS09270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM60_RS09275	COG0626	cystathionine gamma-synthase activity
BRM60_RS09285	COG1760	l-serine dehydratase
BRM60_RS09300	COG2353	YceI-like domain
BRM60_RS09310	COG2353	YceI-like domain
BRM60_RS09360	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BRM60_RS09380	COG1960	acyl-CoA dehydrogenase activity
BRM60_RS09405	COG1024	Enoyl-CoA hydratase
BRM60_RS09405	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM60_RS09420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM60_RS09450	COG1381	Involved in DNA repair and RecF pathway recombination
BRM60_RS09465	COG2954	triphosphatase activity
BRM60_RS09480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRM60_RS09485	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRM60_RS09490	COG3046	protein related to deoxyribodipyrimidine photolyase
BRM60_RS09500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BRM60_RS09505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRM60_RS09510	COG1278	Cold shock
BRM60_RS09530	COG1201	RNA secondary structure unwinding
BRM60_RS09535	COG1793	dna ligase
BRM60_RS09545	COG1793	dna ligase
BRM60_RS09545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRM60_RS09575	COG0183	Belongs to the thiolase family
BRM60_RS09600	COG1451	nucleotide metabolic process
BRM60_RS09615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRM60_RS09660	COG1047	Peptidyl-prolyl cis-trans
BRM60_RS09675	COG2824	Alkylphosphonate utilization operon protein PhnA
BRM60_RS09690	COG1902	pentaerythritol trinitrate reductase activity
BRM60_RS09695	COG2814	Major facilitator Superfamily
BRM60_RS09750	COG0392	lysyltransferase activity
BRM60_RS09750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRM60_RS09760	COG0251	oxidation-reduction process
BRM60_RS09765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM60_RS09780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM60_RS09805	COG1595	DNA-templated transcription, initiation
BRM60_RS09825	COG2878	Part of a membrane complex involved in electron transport
BRM60_RS09835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM60_RS09835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM60_RS09855	COG0833	amino acid
BRM60_RS09860	COG2040	homocysteine
BRM60_RS09875	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM60_RS09910	COG2895	sulfate adenylyltransferase (ATP) activity
BRM60_RS09910	COG0529	Catalyzes the synthesis of activated sulfate
BRM60_RS09955	COG1981	membrane
BRM60_RS09980	COG1131	(ABC) transporter
BRM60_RS09985	COG4771	TonB-dependent receptor
BRM60_RS09995	COG0825	malonyl-CoA metabolic process
BRM60_RS10015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM60_RS10020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM60_RS10040	COG0750	zinc metalloprotease
BRM60_RS10050	COG0575	Belongs to the CDS family
BRM60_RS10060	COG0233	cytoplasmic translational termination
BRM60_RS10075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRM60_RS10135	COG1393	Belongs to the ArsC family
BRM60_RS10150	COG0367	asparagine synthase
BRM60_RS10165	COG4774	siderophore transport
BRM60_RS10205	COG1566	PFAM secretion protein HlyD family protein
BRM60_RS10210	COG2814	Major facilitator Superfamily
BRM60_RS10255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRM60_RS10265	COG1960	acyl-CoA dehydrogenase activity
BRM60_RS10290	COG2914	Belongs to the UPF0125 (RnfH) family
BRM60_RS10300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM60_RS10310	COG0497	DNA recombination
BRM60_RS10320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRM60_RS10325	COG0443	Heat shock 70 kDa protein
BRM60_RS10330	COG0484	heat shock protein binding
BRM60_RS10340	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRM60_RS10345	COG1605	Chorismate mutase
BRM60_RS10345	COG0287	Prephenate dehydrogenase
BRM60_RS10365	COG0583	DNA-binding transcription factor activity
BRM60_RS10380	COG1132	(ABC) transporter
BRM60_RS10415	COG2850	peptidyl-arginine hydroxylation
BRM60_RS10495	COG1131	(ABC) transporter
BRM60_RS10500	COG1725	Transcriptional regulator
BRM60_RS10510	COG0386	Belongs to the glutathione peroxidase family
BRM60_RS10525	COG2900	Belongs to the SlyX family
BRM60_RS10540	COG1609	Transcriptional regulator
BRM60_RS10550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM60_RS10560	COG0646	methionine synthase
BRM60_RS10560	COG1410	methionine synthase
BRM60_RS10565	COG1410	methionine synthase
BRM60_RS10565	COG0646	methionine synthase
BRM60_RS10570	COG2226	methyltransferase
BRM60_RS10575	COG1960	acyl-CoA dehydrogenase activity
BRM60_RS10605	COG0557	exoribonuclease II activity
BRM60_RS10620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM60_RS10635	COG3039	Transposase
BRM60_RS10660	COG3328	transposase activity
BRM60_RS10670	COG1278	Cold shock
BRM60_RS10685	COG3039	Transposase
BRM60_RS10690	COG3039	Transposase
BRM60_RS10750	COG3039	Transposase
BRM60_RS10800	COG3039	Transposase
BRM60_RS10810	COG0583	DNA-binding transcription factor activity
BRM60_RS10870	COG2201	protein-glutamate methylesterase activity
BRM60_RS10905	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BRM60_RS10915	COG0531	amino acid
BRM60_RS10920	COG0531	amino acid
BRM60_RS10930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRM60_RS10935	COG0277	FAD linked oxidase domain protein
BRM60_RS11000	COG0436	Aminotransferase
BRM60_RS11025	COG1187	pseudouridine synthase activity
BRM60_RS11030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRM60_RS11035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRM60_RS11040	COG2350	Protein conserved in bacteria
BRM60_RS11070	COG1175	transmembrane transport
BRM60_RS11075	COG0395	ABC-type sugar transport system, permease component
BRM60_RS11100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM60_RS11110	COG2957	Belongs to the agmatine deiminase family
BRM60_RS11125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRM60_RS11130	COG0539	negative regulation of cytoplasmic translation
BRM60_RS11135	COG0776	regulation of translation
BRM60_RS11145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRM60_RS11150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRM60_RS11160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRM60_RS11180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRM60_RS11195	COG3002	Belongs to the UPF0753 family
BRM60_RS11200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM60_RS11205	COG0583	DNA-binding transcription factor activity
BRM60_RS11235	COG0583	DNA-binding transcription factor activity
BRM60_RS11240	COG0583	DNA-binding transcription factor activity
BRM60_RS11260	COG1914	H( )-stimulated, divalent metal cation uptake system
BRM60_RS11280	COG0668	transmembrane transport
BRM60_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS11340	COG1183	phosphatidylcholine synthase activity
BRM60_RS11350	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRM60_RS11365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM60_RS11365	COG0723	plastoquinol--plastocyanin reductase activity
BRM60_RS11375	COG2183	response to ionizing radiation
BRM60_RS11390	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRM60_RS11405	COG0671	phosphoesterase, PA-phosphatase related
BRM60_RS11435	COG1794	racemase activity, acting on amino acids and derivatives
BRM60_RS11440	COG0697	spore germination
BRM60_RS11445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BRM60_RS11465	COG1012	belongs to the aldehyde dehydrogenase family
BRM60_RS11500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRM60_RS11515	COG0124	histidyl-tRNA synthetase
BRM60_RS11535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRM60_RS11550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BRM60_RS11550	COG0131	Imidazoleglycerol-phosphate dehydratase
BRM60_RS11560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRM60_RS11570	COG0140	phosphoribosyl-ATP diphosphatase activity
BRM60_RS11570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRM60_RS11625	COG0653	protein targeting
BRM60_RS11790	COG2201	protein-glutamate methylesterase activity
BRM60_RS11800	COG2801	Transposase and inactivated derivatives
BRM60_RS11815	COG3039	Transposase
BRM60_RS11840	COG3328	transposase activity
BRM60_RS11875	COG0322	excinuclease ABC activity
BRM60_RS11885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRM60_RS11895	COG1663	tetraacyldisaccharide 4'-kinase activity
BRM60_RS11910	COG0811	peptide transport
BRM60_RS11940	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRM60_RS11955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRM60_RS11970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRM60_RS11985	COG0354	folic acid binding
BRM60_RS12000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM60_RS12010	COG0363	glucosamine-6-phosphate deaminase activity
BRM60_RS12015	COG0129	dihydroxy-acid dehydratase activity
BRM60_RS12020	COG0800	Aldolase
BRM60_RS12050	COG0784	Response regulator, receiver
BRM60_RS12050	COG2205	protein histidine kinase activity
BRM60_RS12050	COG5002	protein histidine kinase activity
BRM60_RS12145	COG0386	Belongs to the glutathione peroxidase family
BRM60_RS12235	COG5001	Diguanylate cyclase
BRM60_RS12235	COG4251	negative regulation of phosphorylation
BRM60_RS12235	COG3706	GGDEF domain
BRM60_RS12235	COG2203	Gaf domain
BRM60_RS12255	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM60_RS12305	COG0617	tRNA 3'-terminal CCA addition
BRM60_RS12315	COG1469	GTP cyclohydrolase I activity
BRM60_RS12320	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM60_RS12370	COG4566	intracellular signal transduction
BRM60_RS12400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRM60_RS12405	COG1605	Chorismate mutase
BRM60_RS12405	COG0077	Prephenate dehydratase
BRM60_RS12415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRM60_RS12460	COG1228	amidohydrolase
BRM60_RS12465	COG2986	histidine ammonia-lyase
BRM60_RS12475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRM60_RS12500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRM60_RS12515	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRM60_RS12530	COG3115	cell septum assembly
BRM60_RS12540	COG0359	binds to the 23S rRNA
BRM60_RS12550	COG0360	Binds together with S18 to 16S ribosomal RNA
BRM60_RS12555	COG0316	Belongs to the HesB IscA family
BRM60_RS12590	COG0288	reversible hydration of carbon dioxide
BRM60_RS12615	COG2925	Exonuclease
BRM60_RS12625	COG0667	Aldo Keto reductase
BRM60_RS12650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM60_RS12650	COG0116	Belongs to the methyltransferase superfamily
BRM60_RS12695	COG0494	nUDIX hydrolase
BRM60_RS12705	COG1024	Enoyl-CoA hydratase
BRM60_RS12715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRM60_RS12730	COG3039	Transposase
BRM60_RS12770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRM60_RS12775	COG0573	inorganic phosphate transmembrane transporter activity
BRM60_RS12790	COG0704	Plays a role in the regulation of phosphate uptake
BRM60_RS12800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM60_RS12815	COG3328	transposase activity
BRM60_RS12850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM60_RS12855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM60_RS12860	COG1862	Preprotein translocase
BRM60_RS12865	COG0343	queuine tRNA-ribosyltransferase activity
BRM60_RS12945	COG0405	Gamma-glutamyltransferase
BRM60_RS12950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRM60_RS12965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRM60_RS12970	COG0742	ribosomal rna small subunit methyltransferase
BRM60_RS12990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRM60_RS13025	COG3039	Transposase
BRM60_RS13055	COG0303	'Molybdopterin
BRM60_RS13065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM60_RS13075	COG1426	Protein conserved in bacteria
BRM60_RS13085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRM60_RS13100	COG1024	Enoyl-CoA hydratase
BRM60_RS13100	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM60_RS13105	COG0183	Belongs to the thiolase family
BRM60_RS13110	COG0038	chloride channel
BRM60_RS13130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRM60_RS13155	COG1674	ftsk spoiiie
BRM60_RS13160	COG0492	ferredoxin-NADP+ reductase activity
BRM60_RS13185	COG0542	response to heat
BRM60_RS13200	COG0482	sulfurtransferase activity
BRM60_RS13225	COG5001	Diguanylate cyclase
BRM60_RS13230	COG4585	Histidine kinase
BRM60_RS13240	COG5002	protein histidine kinase activity
BRM60_RS13260	COG0784	Response regulator, receiver
BRM60_RS13260	COG0835	chemotaxis
BRM60_RS13270	COG1558	bacterial-type flagellum-dependent cell motility
BRM60_RS13275	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRM60_RS13285	COG4787	bacterial-type flagellum-dependent cell motility
BRM60_RS13325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRM60_RS13330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRM60_RS13360	COG2201	protein-glutamate methylesterase activity
BRM60_RS13380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM60_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS13425	COG1677	Flagellar hook-basal body complex protein FliE
BRM60_RS13475	COG3190	flagellar
BRM60_RS13495	COG1684	flagellar biosynthetic protein fliR
BRM60_RS13550	COG2198	Histidine kinase
BRM60_RS13550	COG0784	Response regulator, receiver
BRM60_RS13550	COG0643	Histidine kinase
BRM60_RS13665	COG3039	Transposase
BRM60_RS13675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRM60_RS13680	COG4988	ABC transporter
BRM60_RS13690	COG1271	oxidase subunit
BRM60_RS13720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRM60_RS13740	COG0165	Argininosuccinate lyase
BRM60_RS13755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRM60_RS13760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM60_RS13770	COG0137	argininosuccinate synthase activity
BRM60_RS13775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRM60_RS13790	COG2166	iron-sulfur cluster assembly
BRM60_RS13815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRM60_RS13855	COG3039	Transposase
BRM60_RS13870	COG4677	pectinesterase activity
BRM60_RS13900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRM60_RS13905	COG0402	S-adenosylhomocysteine deaminase activity
BRM60_RS13920	COG1509	lysine 2,3-aminomutase activity
BRM60_RS13940	COG0483	inositol monophosphate 1-phosphatase activity
BRM60_RS13945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM60_RS13970	COG0488	(ABC) transporter
BRM60_RS13975	COG0513	Belongs to the DEAD box helicase family
BRM60_RS13995	COG0625	glutathione transferase activity
BRM60_RS14005	COG1671	Belongs to the UPF0178 family
BRM60_RS14010	COG4681	YaeQ
BRM60_RS14015	COG2081	HI0933 family
BRM60_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS14060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRM60_RS14065	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM60_RS14070	COG0802	atpase or kinase
BRM60_RS14075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRM60_RS14075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRM60_RS14080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM60_RS14105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM60_RS14190	COG3328	transposase activity
BRM60_RS14235	COG2969	positive regulation of protein catabolic process
BRM60_RS14240	COG0625	glutathione transferase activity
BRM60_RS14245	COG2857	Cytochrome c1
BRM60_RS14250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRM60_RS14255	COG0723	plastoquinol--plastocyanin reductase activity
BRM60_RS14265	COG0741	lytic transglycosylase activity
BRM60_RS14290	COG1702	phosphate starvation-inducible protein PhoH
BRM60_RS14310	COG4535	Mg2 and Co2 transporter CorC
BRM60_RS14325	COG1012	belongs to the aldehyde dehydrogenase family
BRM60_RS14335	COG1177	transmembrane transport
BRM60_RS14345	COG3842	ATPase activity
BRM60_RS14385	COG0174	glutamine synthetase
BRM60_RS14390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM60_RS14400	COG0477	Major facilitator Superfamily
BRM60_RS14410	COG0243	molybdopterin cofactor binding
BRM60_RS14420	COG2223	nitrite transmembrane transporter activity
BRM60_RS14430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRM60_RS14435	COG1121	(ABC) transporter
BRM60_RS14445	COG2733	membrane
BRM60_RS14450	COG2205	protein histidine kinase activity
BRM60_RS14450	COG0784	Response regulator, receiver
BRM60_RS14450	COG5002	protein histidine kinase activity
BRM60_RS14460	COG3039	Transposase
BRM60_RS14470	COG2902	Dehydrogenase
BRM60_RS14480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM60_RS14485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM60_RS14505	COG1609	Transcriptional regulator
BRM60_RS14510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM60_RS14510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM60_RS14515	COG1105	Belongs to the carbohydrate kinase PfkB family
BRM60_RS14520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM60_RS14520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM60_RS14535	COG3039	Transposase
BRM60_RS14695	COG3039	Transposase
BRM60_RS14725	COG4771	TonB-dependent receptor
BRM60_RS14735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM60_RS14755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRM60_RS14760	COG1360	Flagellar Motor Protein
BRM60_RS14770	COG0835	chemotaxis
BRM60_RS14780	COG0745	RESPONSE REGULATOR receiver
BRM60_RS14805	COG0840	transmembrane signaling receptor activity
BRM60_RS14820	COG0840	transmembrane signaling receptor activity
BRM60_RS14830	COG0840	transmembrane signaling receptor activity
BRM60_RS14840	COG0840	transmembrane signaling receptor activity
BRM60_RS14845	COG0840	transmembrane signaling receptor activity
BRM60_RS14850	COG0840	transmembrane signaling receptor activity
BRM60_RS14855	COG0840	transmembrane signaling receptor activity
BRM60_RS14875	COG0835	chemotaxis
BRM60_RS14900	COG0840	transmembrane signaling receptor activity
BRM60_RS14935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM60_RS14965	COG0318	PFAM AMP-dependent synthetase and ligase
BRM60_RS14970	COG1024	Enoyl-CoA hydratase
BRM60_RS14975	COG2205	protein histidine kinase activity
BRM60_RS14975	COG2198	Histidine kinase
BRM60_RS14975	COG0784	Response regulator, receiver
BRM60_RS15045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRM60_RS15055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM60_RS15060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRM60_RS15070	COG0505	Belongs to the CarA family
BRM60_RS15075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRM60_RS15085	COG2258	MOSC domain
BRM60_RS15090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRM60_RS15140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRM60_RS15160	COG0477	Major facilitator Superfamily
BRM60_RS15170	COG1070	Carbohydrate kinase
BRM60_RS15180	COG1501	Belongs to the glycosyl hydrolase 31 family
BRM60_RS15195	COG0800	Aldolase
BRM60_RS15200	COG4948	Mandelate Racemase Muconate Lactonizing
BRM60_RS15210	COG3734	2-keto-3-deoxy-galactonokinase
BRM60_RS15215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRM60_RS15225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM60_RS15240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRM60_RS15245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRM60_RS15255	COG0351	phosphomethylpyrimidine kinase
BRM60_RS15285	COG0583	DNA-binding transcription factor activity
BRM60_RS15290	COG1741	Belongs to the pirin family
BRM60_RS15310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRM60_RS15315	COG0305	Participates in initiation and elongation during chromosome replication
BRM60_RS15340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRM60_RS15345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRM60_RS15350	COG2137	regulation of response to DNA damage stimulus
BRM60_RS15360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRM60_RS15375	COG1546	Belongs to the CinA family
BRM60_RS15380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRM60_RS15395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRM60_RS15405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRM60_RS15410	COG1534	Rna-binding protein
BRM60_RS15425	COG1238	metal cluster binding
BRM60_RS15430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM60_RS15435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRM60_RS15440	COG2840	Smr protein MutS2
BRM60_RS15450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRM60_RS15460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BRM60_RS15465	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRM60_RS15470	COG0148	phosphopyruvate hydratase activity
BRM60_RS15480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRM60_RS15485	COG0504	CTP synthase activity
BRM60_RS15515	COG0306	phosphate transporter
BRM60_RS15530	COG1253	flavin adenine dinucleotide binding
BRM60_RS15545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRM60_RS15565	COG0477	Major facilitator Superfamily
BRM60_RS15575	COG1132	(ABC) transporter
BRM60_RS15580	COG1136	(ABC) transporter
BRM60_RS15600	COG0438	transferase activity, transferring glycosyl groups
BRM60_RS15610	COG2264	protein methyltransferase activity
BRM60_RS15640	COG2244	polysaccharide biosynthetic process
BRM60_RS15690	COG1595	DNA-templated transcription, initiation
BRM60_RS15705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM60_RS15725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM60_RS15800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM60_RS15805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM60_RS15860	COG1858	cytochrome C peroxidase
BRM60_RS15895	COG0515	serine threonine protein kinase
BRM60_RS15900	COG0631	protein serine/threonine phosphatase activity
BRM60_RS16010	COG3039	Transposase
BRM60_RS16030	COG3039	Transposase
BRM60_RS16075	COG0316	Belongs to the HesB IscA family
BRM60_RS16075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRM60_RS16080	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRM60_RS16090	COG0428	transporter
BRM60_RS16095	COG0428	transporter
BRM60_RS16100	COG3064	Membrane
BRM60_RS16110	COG1530	ribonuclease E activity
BRM60_RS16130	COG1054	Belongs to the UPF0176 family
BRM60_RS16135	COG3039	Transposase
BRM60_RS16155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRM60_RS16195	COG3039	Transposase
BRM60_RS16200	COG3039	Transposase
BRM60_RS16235	COG1648	precorrin-2 dehydrogenase activity
BRM60_RS16235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRM60_RS16260	COG0746	molybdenum cofactor guanylyltransferase activity
BRM60_RS16340	COG4206	TonB-dependent receptor
BRM60_RS16370	COG4206	TonB-dependent receptor
BRM60_RS16420	COG0531	amino acid
BRM60_RS16435	COG0006	proline dipeptidase activity
BRM60_RS16445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM60_RS16460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM60_RS16465	COG3938	Belongs to the proline racemase family
BRM60_RS16475	COG0552	protein localization to endoplasmic reticulum
BRM60_RS16500	COG4191	Histidine kinase
BRM60_RS16500	COG0784	Response regulator, receiver
BRM60_RS16590	COG3040	lipid binding
BRM60_RS16630	COG0438	transferase activity, transferring glycosyl groups
BRM60_RS16640	COG0438	transferase activity, transferring glycosyl groups
BRM60_RS16645	COG0438	transferase activity, transferring glycosyl groups
BRM60_RS16715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRM60_RS16745	COG0556	nucleotide-excision repair
BRM60_RS16750	COG4969	Belongs to the N-Me-Phe pilin family
BRM60_RS16790	COG1611	Belongs to the LOG family
BRM60_RS16805	COG2095	MarC family integral membrane protein
BRM60_RS16815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM60_RS16850	COG1185	polyribonucleotide nucleotidyltransferase activity
BRM60_RS16855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRM60_RS16875	COG0195	Participates in both transcription termination and antitermination
BRM60_RS16880	COG0779	Required for maturation of 30S ribosomal subunits
BRM60_RS16890	COG1007	ATP synthesis coupled electron transport
BRM60_RS16920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BRM60_RS16925	COG1034	ATP synthesis coupled electron transport
BRM60_RS16930	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRM60_RS16935	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRM60_RS16940	COG0649	NAD binding
BRM60_RS16945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM60_RS16955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM60_RS16970	COG0149	triose-phosphate isomerase activity
BRM60_RS17020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM60_RS17025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRM60_RS17040	COG0133	tryptophan synthase activity
BRM60_RS17050	COG0135	phosphoribosylanthranilate isomerase activity
BRM60_RS17055	COG0101	tRNA pseudouridine synthase activity
BRM60_RS17075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRM60_RS17080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRM60_RS17085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRM60_RS17090	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM60_RS17120	COG0433	COG0433 Predicted ATPase
BRM60_RS17125	COG2826	transposase and inactivated derivatives, IS30 family
BRM60_RS17145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM60_RS17155	COG0412	Dienelactone hydrolase
BRM60_RS17175	COG0717	Belongs to the dCTP deaminase family
BRM60_RS17180	COG0489	protein tyrosine kinase activity
BRM60_RS17225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM60_RS17230	COG2311	Membrane
BRM60_RS17235	COG1047	Peptidyl-prolyl cis-trans
BRM60_RS17240	COG0791	NLP P60 protein
BRM60_RS17245	COG0791	NLP P60 protein
BRM60_RS17260	COG1301	dicarboxylic acid transport
BRM60_RS17265	COG1785	Belongs to the alkaline phosphatase family
BRM60_RS17270	COG0037	tRNA processing
BRM60_RS17275	COG1722	exodeoxyribonuclease VII activity
BRM60_RS17280	COG0142	geranyltranstransferase activity
BRM60_RS17305	COG0312	modulator of DNA gyrase
BRM60_RS17310	COG3028	Belongs to the UPF0307 family
BRM60_RS17315	COG0312	modulator of DNA gyrase
BRM60_RS17325	COG3164	Protein of unknown function
BRM60_RS17340	COG2968	Membrane
BRM60_RS17365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRM60_RS17390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRM60_RS17420	COG3118	belongs to the thioredoxin family
BRM60_RS17505	COG3039	Transposase
BRM60_RS17600	COG2022	thiamine diphosphate biosynthetic process
BRM60_RS17615	COG0471	metal ion transport
BRM60_RS17615	COG3273	potassium ion transport
BRM60_RS17645	COG1970	mechanosensitive ion channel activity
BRM60_RS17670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM60_RS17700	COG0308	aminopeptidase N
BRM60_RS17705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM60_RS17720	COG2895	sulfate adenylyltransferase (ATP) activity
BRM60_RS17720	COG0529	Catalyzes the synthesis of activated sulfate
BRM60_RS17725	COG0175	sulfate reduction
BRM60_RS17730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM60_RS17735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRM60_RS17740	COG0175	sulfate reduction
BRM60_RS17760	COG0784	Response regulator, receiver
BRM60_RS17760	COG2198	Histidine kinase
BRM60_RS17760	COG2205	protein histidine kinase activity
BRM60_RS17805	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRM60_RS17810	COG3588	fructose-bisphosphate aldolase
BRM60_RS17815	COG0469	pyruvate kinase activity
BRM60_RS17860	COG0753	catalase activity
BRM60_RS17885	COG3039	Transposase
BRM60_RS17905	COG2207	Transcriptional regulator
BRM60_RS17905	COG1917	Cupin 2, conserved barrel domain protein
BRM60_RS17935	COG0823	Involved in the tonB-independent uptake of proteins
BRM60_RS17935	COG1506	peptidase
BRM60_RS17960	COG3039	Transposase
BRM60_RS17965	COG1297	OPT oligopeptide transporter protein
BRM60_RS18070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRM60_RS18085	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRM60_RS18090	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRM60_RS18095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRM60_RS18115	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRM60_RS18295	COG3179	chitinase
BRM60_RS18390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM60_RS18455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM60_RS18465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM60_RS18555	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRM60_RS18570	COG2197	response regulator
BRM60_RS18575	COG4585	Histidine kinase
BRM60_RS18595	COG2894	cell division
BRM60_RS18600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRM60_RS18610	COG0642	Histidine kinase
BRM60_RS18615	COG0745	RESPONSE REGULATOR receiver
BRM60_RS18620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRM60_RS18630	COG2194	sulfuric ester hydrolase activity
BRM60_RS18660	COG3551	Protein conserved in bacteria
BRM60_RS18725	COG0203	ribosomal protein L17
BRM60_RS18735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRM60_RS18740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRM60_RS18750	COG0201	protein transport
BRM60_RS18760	COG1841	ribosomal large subunit assembly
BRM60_RS18790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRM60_RS18800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRM60_RS18805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRM60_RS18810	COG0255	Belongs to the universal ribosomal protein uL29 family
BRM60_RS18815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRM60_RS18825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRM60_RS18840	COG0089	rRNA binding
BRM60_RS18845	COG0088	Forms part of the polypeptide exit tunnel
BRM60_RS18850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRM60_RS18855	COG0051	transcription antitermination factor activity, RNA binding
BRM60_RS18875	COG0049	tRNA binding
BRM60_RS18880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRM60_RS18885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRM60_RS18890	COG0085	RNA polymerase activity
BRM60_RS18895	COG0222	ribosome binding
BRM60_RS18900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRM60_RS18910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRM60_RS18920	COG0250	Participates in transcription elongation, termination and antitermination
BRM60_RS18925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRM60_RS18955	COG0012	GTP binding
BRM60_RS18960	COG0193	aminoacyl-tRNA hydrolase activity
BRM60_RS18970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRM60_RS18985	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BRM60_RS19000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRM60_RS19010	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRM60_RS19030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM60_RS19035	COG1295	ribonuclease BN
BRM60_RS19065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRM60_RS19075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRM60_RS19105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRM60_RS19130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRM60_RS19145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM60_RS19145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM60_RS19195	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM60_RS19205	COG3634	alkyl hydroperoxide reductase activity
BRM60_RS19210	COG0583	DNA-binding transcription factor activity
BRM60_RS19220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM60_RS19300	COG4783	chaperone-mediated protein folding
BRM60_RS19315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRM60_RS19325	COG0438	transferase activity, transferring glycosyl groups
BRM60_RS19330	COG0671	phosphoesterase, PA-phosphatase related
BRM60_RS19335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM60_RS19355	COG2833	Protein of unknown function (DUF455)
BRM60_RS19375	COG0285	dihydrofolate synthase activity
BRM60_RS19385	COG0406	alpha-ribazole phosphatase activity
BRM60_RS19430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRM60_RS19435	COG4208	sulfate ABC transporter
BRM60_RS19440	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRM60_RS19445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRM60_RS19450	COG0156	8-amino-7-oxononanoate synthase activity
BRM60_RS19480	COG0604	alcohol dehydrogenase
BRM60_RS19485	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRM60_RS19485	COG1902	pentaerythritol trinitrate reductase activity
BRM60_RS19620	COG3386	PFAM SMP-30 Gluconolaconase
BRM60_RS19640	COG1024	Enoyl-CoA hydratase
BRM60_RS19650	COG0318	PFAM AMP-dependent synthetase and ligase
BRM60_RS19655	COG0583	DNA-binding transcription factor activity
BRM60_RS19695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM60_RS19700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM60_RS19710	COG2096	Adenosyltransferase
BRM60_RS19715	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRM60_RS19730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRM60_RS19740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRM60_RS19745	COG2967	ApaG domain
BRM60_RS19770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRM60_RS19790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRM60_RS19805	COG0642	Histidine kinase
BRM60_RS19820	COG4181	ATPase activity
BRM60_RS19830	COG2175	clavaminate synthase activity
BRM60_RS19840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BRM60_RS19880	COG0667	Aldo Keto reductase
BRM60_RS19890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRM60_RS19895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM60_RS19915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM60_RS19930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRM60_RS19985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRM60_RS19990	COG2226	methyltransferase
BRM60_RS20045	COG0604	alcohol dehydrogenase
BRM60_RS20045	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS20045	COG3321	synthase
BRM60_RS20060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRM60_RS20080	COG0494	nUDIX hydrolase
BRM60_RS20095	COG4942	peptidase
BRM60_RS20095	COG1388	LysM domain
BRM60_RS20105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRM60_RS20120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRM60_RS20125	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRM60_RS20130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM60_RS20150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRM60_RS20165	COG3116	cell division
BRM60_RS20170	COG0275	rRNA processing
BRM60_RS20205	COG0792	nuclease activity
BRM60_RS20210	COG1988	membrane-bound metal-dependent
BRM60_RS20215	COG0277	FAD linked oxidase domain protein
BRM60_RS20220	COG0745	RESPONSE REGULATOR receiver
BRM60_RS20225	COG2205	protein histidine kinase activity
BRM60_RS20235	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRM60_RS20240	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRM60_RS20265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRM60_RS20270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM60_RS20275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRM60_RS20295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM60_RS20295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM60_RS20315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRM60_RS20335	COG0488	(ABC) transporter
BRM60_RS20385	COG2205	protein histidine kinase activity
BRM60_RS20420	COG2205	protein histidine kinase activity
BRM60_RS20440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRM60_RS20475	COG3039	Transposase
BRM60_RS20480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM60_RS20495	COG3039	Transposase
BRM60_RS20550	COG3039	Transposase
BRM60_RS20600	COG0726	polysaccharide deacetylase
BRM60_RS20600	COG1649	PFAM Uncharacterised BCR, COG1649
BRM60_RS20605	COG1215	transferase activity, transferring glycosyl groups
BRM60_RS20615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRM60_RS20620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM60_RS20625	COG1609	Transcriptional regulator
BRM60_RS20635	COG2188	Transcriptional regulator
BRM60_RS20650	COG3250	beta-galactosidase activity
BRM60_RS20690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRM60_RS20695	COG4191	Histidine kinase
BRM60_RS20700	COG0784	Response regulator, receiver
BRM60_RS20705	COG4251	negative regulation of phosphorylation
BRM60_RS20710	COG2823	Periplasmic or secreted lipoprotein
BRM60_RS20715	COG0673	inositol 2-dehydrogenase activity
BRM60_RS20720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRM60_RS20755	COG1056	cytidyltransferase-related domain
BRM60_RS20755	COG1051	belongs to the nudix hydrolase family
BRM60_RS20800	COG2921	Belongs to the UPF0250 family
BRM60_RS20815	COG1686	Belongs to the peptidase S11 family
BRM60_RS20825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRM60_RS20830	COG2951	lytic endotransglycosylase activity
BRM60_RS20875	COG0772	Belongs to the SEDS family
BRM60_RS20890	COG1792	Involved in formation and maintenance of cell shape
BRM60_RS20895	COG1077	Cell shape determining protein MreB Mrl
BRM60_RS20900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM60_RS20945	COG2199	diguanylate cyclase activity
BRM60_RS20950	COG0308	aminopeptidase N
BRM60_RS20980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRM60_RS21010	COG0436	Aminotransferase
BRM60_RS21025	COG1505	serine-type exopeptidase activity
BRM60_RS21050	COG0181	hydroxymethylbilane synthase activity
BRM60_RS21060	COG3275	phosphorelay sensor kinase activity
BRM60_RS21105	COG0659	secondary active sulfate transmembrane transporter activity
BRM60_RS21110	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM60_RS21110	COG5297	Belongs to the glycosyl hydrolase family 6
BRM60_RS21185	COG0598	Magnesium transport protein CorA
BRM60_RS21195	COG1113	amino acid transport
BRM60_RS21205	COG5297	Belongs to the glycosyl hydrolase family 6
BRM60_RS21210	COG4305	rare lipoprotein A
BRM60_RS21215	COG0697	spore germination
BRM60_RS21275	COG4221	oxidoreductase activity
BRM60_RS21305	COG0456	acetyltransferase
BRM60_RS21315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRM60_RS21350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM60_RS21350	COG2111	Na H antiporter
BRM60_RS21355	COG1006	Multisubunit Na H antiporter MnhC subunit
BRM60_RS21360	COG0651	ATP synthesis coupled electron transport
BRM60_RS21370	COG2212	antiporter activity
BRM60_RS21375	COG1320	monovalent cation:proton antiporter activity
BRM60_RS21390	COG3039	Transposase
BRM60_RS21395	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BRM60_RS21415	COG3104	oligopeptide transport
BRM60_RS21420	COG3483	tryptophan 2,3-dioxygenase activity
BRM60_RS21430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRM60_RS21470	COG0183	Belongs to the thiolase family
BRM60_RS21525	COG3039	Transposase
BRM60_RS21555	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRM60_RS21560	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRM60_RS21570	COG4948	Mandelate Racemase Muconate Lactonizing
BRM60_RS21610	COG0531	amino acid
BRM60_RS21645	COG4682	membrane
BRM60_RS21650	COG2133	pyrroloquinoline quinone binding
BRM60_RS21690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRM60_RS21695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRM60_RS21705	COG1610	YqeY-like protein
BRM60_RS21720	COG1295	ribonuclease BN
BRM60_RS21725	COG0358	DNA primase activity
BRM60_RS21790	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRM60_RS21805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRM60_RS21855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRM60_RS21860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRM60_RS21865	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BRM60_RS21875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BRM60_RS21880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM60_RS21895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRM60_RS21995	COG3039	Transposase
BRM60_RS22010	COG3328	transposase activity
BRM60_RS22025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM60_RS22025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM60_RS22035	COG1473	amidohydrolase
BRM60_RS22040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM60_RS22045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM60_RS22060	COG5383	Protein conserved in bacteria
BRM60_RS22090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRM60_RS22095	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRM60_RS22110	COG0028	Belongs to the TPP enzyme family
BRM60_RS22115	COG4191	Histidine kinase
BRM60_RS22140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRM60_RS22155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM60_RS22160	COG3177	Filamentation induced by cAMP protein fic
BRM60_RS22175	COG0596	Alpha beta hydrolase
BRM60_RS22180	COG0727	PFAM Uncharacterised protein family (UPF0153)
BRM60_RS22185	COG0318	PFAM AMP-dependent synthetase and ligase
BRM60_RS22190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRM60_RS22245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRM60_RS22255	COG0129	dihydroxy-acid dehydratase activity
BRM60_RS22285	COG3039	Transposase
BRM60_RS22295	COG0408	coproporphyrinogen oxidase activity
BRM60_RS22395	COG2353	YceI-like domain
BRM60_RS22425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM60_RS22440	COG3386	PFAM SMP-30 Gluconolaconase
BRM60_RS22485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRM60_RS22500	COG4771	TonB-dependent receptor
BRM60_RS22510	COG0459	protein refolding
BRM60_RS22535	COG1252	NADH dehydrogenase
BRM60_RS22545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM60_RS22550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRM60_RS22555	COG3437	response regulator, receiver
BRM60_RS22560	COG2177	Part of the ABC transporter FtsEX involved in
BRM60_RS22565	COG2884	Cell division ATP-binding protein ftsE
BRM60_RS22575	COG3118	belongs to the thioredoxin family
BRM60_RS22580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRM60_RS22595	COG0729	surface antigen
BRM60_RS22600	COG2911	Protein conserved in bacteria
BRM60_RS22635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM60_RS22650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM60_RS22710	COG1733	regulation of RNA biosynthetic process
BRM60_RS22715	COG0702	epimerase
BRM60_RS22750	COG0583	DNA-binding transcription factor activity
BRM60_RS22755	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM60_RS22775	COG0745	RESPONSE REGULATOR receiver
BRM60_RS22805	COG1902	pentaerythritol trinitrate reductase activity
BRM60_RS22810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRM60_RS22820	COG2814	Major facilitator Superfamily
BRM60_RS22825	COG0583	DNA-binding transcription factor activity
BRM60_RS22845	COG0084	hydrolase, TatD family'
BRM60_RS22895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM60_RS22915	COG2072	flavoprotein involved in K transport
BRM60_RS22965	COG4770	biotin carboxylase activity
BRM60_RS22970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRM60_RS22975	COG1960	acyl-CoA dehydrogenase activity
BRM60_RS23030	COG0523	cobalamin synthesis protein
BRM60_RS23040	COG0697	spore germination
BRM60_RS23050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRM60_RS23065	COG4771	TonB-dependent receptor
BRM60_RS23070	COG0457	Tetratricopeptide repeat
BRM60_RS23085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM60_RS23110	COG0519	Catalyzes the synthesis of GMP from XMP
BRM60_RS23110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRM60_RS23120	COG0805	protein transport
BRM60_RS23130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRM60_RS23140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRM60_RS23195	COG3661	Belongs to the glycosyl hydrolase 67 family
BRM60_RS23205	COG4948	Mandelate Racemase Muconate Lactonizing
BRM60_RS23215	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM60_RS23220	COG0246	Mannitol dehydrogenase
BRM60_RS23245	COG3693	PFAM glycoside hydrolase, family 10
BRM60_RS23270	COG2211	Major facilitator Superfamily
BRM60_RS23315	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRM60_RS23365	COG1846	Transcriptional regulator
BRM60_RS23370	COG1764	response to oxidative stress
BRM60_RS23480	COG3549	Plasmid maintenance system killer
BRM60_RS23490	COG1074	ATP-dependent DNA helicase activity
BRM60_RS23495	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRM60_RS23535	COG2032	superoxide dismutase activity
BRM60_RS23540	COG2032	superoxide dismutase activity
BRM60_RS23545	COG2204	response regulator
BRM60_RS23550	COG3852	Histidine kinase
BRM60_RS23555	COG0004	ammonium transporteR
BRM60_RS23560	COG0347	Belongs to the P(II) protein family
BRM60_RS23565	COG0174	glutamine synthetase
BRM60_RS23570	COG1968	undecaprenyl-diphosphatase activity
BRM60_RS23615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM60_RS23625	COG2062	phosphohistidine phosphatase, SixA
BRM60_RS23630	COG0489	protein tyrosine kinase activity
BRM60_RS23650	COG1396	sequence-specific DNA binding
BRM60_RS23655	COG3550	peptidyl-serine autophosphorylation
BRM60_RS23660	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRM60_RS23665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM60_RS23680	COG1125	glycine betaine transport
BRM60_RS23680	COG0517	IMP dehydrogenase activity
BRM60_RS23695	COG1119	ATPase activity
BRM60_RS23705	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRM60_RS23720	COG3039	Transposase
BRM60_RS23745	COG0656	L-ascorbic acid biosynthetic process
BRM60_RS23750	COG2130	NADP-dependent
BRM60_RS23755	COG0667	Aldo Keto reductase
BRM60_RS23765	COG1187	pseudouridine synthase activity
BRM60_RS23780	COG1643	Atp-dependent helicase
BRM60_RS23785	COG4807	Protein conserved in bacteria
BRM60_RS23790	COG4948	Mandelate Racemase Muconate Lactonizing
BRM60_RS23800	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRM60_RS23805	COG1028	Short-chain dehydrogenase reductase Sdr
BRM60_RS23825	COG3507	Belongs to the glycosyl hydrolase 43 family
BRM60_RS23870	COG3162	membrane
BRM60_RS23875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRM60_RS23890	COG0708	Exodeoxyribonuclease III
BRM60_RS23905	COG2091	lysine biosynthetic process via aminoadipic acid
BRM60_RS23915	COG3540	Alkaline phosphatase
BRM60_RS23945	COG2159	amidohydrolase
BRM60_RS23970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM60_RS23975	COG0583	DNA-binding transcription factor activity
BRM60_RS23980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM60_RS24000	COG0210	DNA helicase
BRM60_RS24015	COG0531	amino acid
BRM60_RS24025	COG1322	Protein conserved in bacteria
BRM60_RS24035	COG0386	Belongs to the glutathione peroxidase family
BRM60_RS24090	COG0793	Belongs to the peptidase S41A family
BRM60_RS24095	COG4942	peptidase
BRM60_RS24105	COG2234	aminopeptidase activity
BRM60_RS24155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRM60_RS24160	COG0302	gtp cyclohydrolase
BRM60_RS24185	COG0477	Major facilitator Superfamily
BRM60_RS24290	COG1929	Belongs to the glycerate kinase type-1 family
BRM60_RS24295	COG2271	Major facilitator Superfamily
BRM60_RS24310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM60_RS24320	COG0861	Integral membrane protein TerC family
BRM60_RS24330	COG0584	glycerophosphoryl diester phosphodiesterase
BRM60_RS24340	COG0671	phosphoesterase, PA-phosphatase related
BRM60_RS24350	COG0726	polysaccharide deacetylase