locus-tag	class	description
DZA53_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DZA53_RS00030	COG0187	DNA topoisomerase II activity
DZA53_RS00040	COG0501	Belongs to the peptidase M48B family
DZA53_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DZA53_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DZA53_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DZA53_RS00100	COG4772	TonB-dependent receptor
DZA53_RS00115	COG3039	Transposase
DZA53_RS00120	COG1304	FMN binding
DZA53_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DZA53_RS00255	COG2826	transposase and inactivated derivatives, IS30 family
DZA53_RS00280	COG3039	Transposase
DZA53_RS00290	COG1090	epimerase
DZA53_RS00300	COG0642	Histidine kinase
DZA53_RS00310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DZA53_RS00420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DZA53_RS00500	COG1511	domain protein
DZA53_RS00500	COG3264	Mechanosensitive ion channel
DZA53_RS00525	COG3039	Transposase
DZA53_RS00545	COG3039	Transposase
DZA53_RS00550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DZA53_RS00560	COG2354	Protein conserved in bacteria
DZA53_RS00565	COG1649	PFAM Uncharacterised BCR, COG1649
DZA53_RS00585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DZA53_RS00610	COG0702	epimerase
DZA53_RS00625	COG1858	cytochrome C peroxidase
DZA53_RS00715	COG0513	Belongs to the DEAD box helicase family
DZA53_RS00725	COG3039	Transposase
DZA53_RS00775	COG1136	(ABC) transporter
DZA53_RS00790	COG3039	Transposase
DZA53_RS00800	COG3039	Transposase
DZA53_RS00815	COG1136	(ABC) transporter
DZA53_RS00860	COG1272	protein, Hemolysin III
DZA53_RS00865	COG1111	helicase
DZA53_RS00865	COG1205	dead DEAH box helicase
DZA53_RS00930	COG0069	glutamate synthase activity
DZA53_RS00930	COG0070	glutamate synthase
DZA53_RS00930	COG0067	glutamate synthase
DZA53_RS00935	COG0493	'glutamate synthase
DZA53_RS00990	COG1609	Transcriptional regulator
DZA53_RS01025	COG0366	Alpha amylase catalytic
DZA53_RS01030	COG0366	Alpha amylase catalytic
DZA53_RS01100	COG0606	chelatase, subunit chli
DZA53_RS01155	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DZA53_RS01160	COG1166	arginine decarboxylase activity
DZA53_RS01225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DZA53_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS01275	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DZA53_RS01290	COG0210	DNA helicase
DZA53_RS01305	COG3132	Protein of unknown function, DUF480
DZA53_RS01310	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DZA53_RS01315	COG0284	orotidine-5'-phosphate decarboxylase activity
DZA53_RS01350	COG2937	Belongs to the GPAT DAPAT family
DZA53_RS01420	COG1752	Esterase of the alpha-beta hydrolase superfamily
DZA53_RS01430	COG1119	ATPase activity
DZA53_RS01445	COG1125	glycine betaine transport
DZA53_RS01445	COG0517	IMP dehydrogenase activity
DZA53_RS01460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DZA53_RS01465	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DZA53_RS01470	COG3550	peptidyl-serine autophosphorylation
DZA53_RS01475	COG1396	sequence-specific DNA binding
DZA53_RS01495	COG0489	protein tyrosine kinase activity
DZA53_RS01500	COG2062	phosphohistidine phosphatase, SixA
DZA53_RS01510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DZA53_RS01555	COG1968	undecaprenyl-diphosphatase activity
DZA53_RS01560	COG0174	glutamine synthetase
DZA53_RS01565	COG0347	Belongs to the P(II) protein family
DZA53_RS01570	COG0004	ammonium transporteR
DZA53_RS01575	COG3852	Histidine kinase
DZA53_RS01580	COG2204	response regulator
DZA53_RS01585	COG2032	superoxide dismutase activity
DZA53_RS01590	COG2032	superoxide dismutase activity
DZA53_RS01625	COG1196	nuclear chromosome segregation
DZA53_RS01635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DZA53_RS01640	COG1074	ATP-dependent DNA helicase activity
DZA53_RS01650	COG3549	Plasmid maintenance system killer
DZA53_RS01750	COG1764	response to oxidative stress
DZA53_RS01755	COG1846	Transcriptional regulator
DZA53_RS01805	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DZA53_RS01850	COG2211	Major facilitator Superfamily
DZA53_RS01875	COG3693	PFAM glycoside hydrolase, family 10
DZA53_RS01900	COG0246	Mannitol dehydrogenase
DZA53_RS01905	COG1472	Belongs to the glycosyl hydrolase 3 family
DZA53_RS01915	COG4948	Mandelate Racemase Muconate Lactonizing
DZA53_RS01925	COG3661	Belongs to the glycosyl hydrolase 67 family
DZA53_RS01945	COG0037	tRNA processing
DZA53_RS01950	COG2974	May be involved in recombination
DZA53_RS01975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DZA53_RS01985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DZA53_RS01995	COG0805	protein transport
DZA53_RS02005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DZA53_RS02005	COG0519	Catalyzes the synthesis of GMP from XMP
DZA53_RS02030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DZA53_RS02035	COG0752	glycyl-tRNA synthetase alpha subunit
DZA53_RS02045	COG0457	Tetratricopeptide repeat
DZA53_RS02050	COG4771	TonB-dependent receptor
DZA53_RS02065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DZA53_RS02085	COG0523	cobalamin synthesis protein
DZA53_RS02140	COG1960	acyl-CoA dehydrogenase activity
DZA53_RS02145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DZA53_RS02150	COG4770	biotin carboxylase activity
DZA53_RS02220	COG2072	flavoprotein involved in K transport
DZA53_RS02240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DZA53_RS02295	COG0084	hydrolase, TatD family'
DZA53_RS02315	COG0583	DNA-binding transcription factor activity
DZA53_RS02320	COG2814	Major facilitator Superfamily
DZA53_RS02330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DZA53_RS02335	COG1902	pentaerythritol trinitrate reductase activity
DZA53_RS02365	COG0745	RESPONSE REGULATOR receiver
DZA53_RS02385	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DZA53_RS02390	COG0583	DNA-binding transcription factor activity
DZA53_RS02420	COG0702	epimerase
DZA53_RS02425	COG1733	regulation of RNA biosynthetic process
DZA53_RS02485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DZA53_RS02500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DZA53_RS02535	COG2911	Protein conserved in bacteria
DZA53_RS02540	COG0729	surface antigen
DZA53_RS02555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DZA53_RS02560	COG3118	belongs to the thioredoxin family
DZA53_RS02570	COG2884	Cell division ATP-binding protein ftsE
DZA53_RS02575	COG2177	Part of the ABC transporter FtsEX involved in
DZA53_RS02580	COG3437	response regulator, receiver
DZA53_RS02585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DZA53_RS02590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DZA53_RS02600	COG1252	NADH dehydrogenase
DZA53_RS02625	COG0459	protein refolding
DZA53_RS02635	COG4771	TonB-dependent receptor
DZA53_RS02650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DZA53_RS02695	COG3386	PFAM SMP-30 Gluconolaconase
DZA53_RS02710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DZA53_RS02745	COG0778	Nitroreductase
DZA53_RS02750	COG2353	YceI-like domain
DZA53_RS02845	COG0408	coproporphyrinogen oxidase activity
DZA53_RS02855	COG3039	Transposase
DZA53_RS02880	COG0129	dihydroxy-acid dehydratase activity
DZA53_RS02890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DZA53_RS02930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DZA53_RS02935	COG0318	PFAM AMP-dependent synthetase and ligase
DZA53_RS02940	COG0727	PFAM Uncharacterised protein family (UPF0153)
DZA53_RS02945	COG0596	Alpha beta hydrolase
DZA53_RS02960	COG3177	Filamentation induced by cAMP protein fic
DZA53_RS02965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DZA53_RS02980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DZA53_RS03005	COG4191	Histidine kinase
DZA53_RS03010	COG0028	Belongs to the TPP enzyme family
DZA53_RS03025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DZA53_RS03030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DZA53_RS03070	COG5383	Protein conserved in bacteria
DZA53_RS03085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DZA53_RS03090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DZA53_RS03095	COG1473	amidohydrolase
DZA53_RS03105	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DZA53_RS03105	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DZA53_RS03185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DZA53_RS03200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DZA53_RS03205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DZA53_RS03215	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DZA53_RS03220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DZA53_RS03225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DZA53_RS03275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DZA53_RS03290	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DZA53_RS03355	COG3039	Transposase
DZA53_RS03380	COG1271	oxidase subunit
DZA53_RS03445	COG2972	Histidine kinase
DZA53_RS03470	COG0531	amino acid
DZA53_RS03490	COG3590	peptidase
DZA53_RS03500	COG0667	Aldo Keto reductase
DZA53_RS03515	COG3384	dioxygenase
DZA53_RS03525	COG1573	uracil-dna glycosylase
DZA53_RS03535	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DZA53_RS03545	COG0025	NhaP-type Na H and K H
DZA53_RS03550	COG1131	(ABC) transporter
DZA53_RS03555	COG0842	Transport permease protein
DZA53_RS03570	COG1404	Belongs to the peptidase S8 family
DZA53_RS03585	COG0745	RESPONSE REGULATOR receiver
DZA53_RS03635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DZA53_RS03660	COG2205	protein histidine kinase activity
DZA53_RS03660	COG2202	Pas domain
DZA53_RS03690	COG2813	Specifically methylates the guanine in position
DZA53_RS03695	COG1187	pseudouridine synthase activity
DZA53_RS03700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DZA53_RS03740	COG0697	spore germination
DZA53_RS03750	COG2011	ABC-type metal ion transport system permease component
DZA53_RS03780	COG0508	dehydrogenase complex catalyzes the overall conversion of
DZA53_RS03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DZA53_RS03810	COG0356	it plays a direct role in the translocation of protons across the membrane
DZA53_RS03820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DZA53_RS03830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DZA53_RS03835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DZA53_RS03840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DZA53_RS03845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DZA53_RS03900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DZA53_RS03905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DZA53_RS03955	COG0339	signal peptide processing
DZA53_RS03995	COG1956	GAF domain-containing protein
DZA53_RS04000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DZA53_RS04010	COG0720	synthase
DZA53_RS04020	COG0513	Belongs to the DEAD box helicase family
DZA53_RS04035	COG0625	glutathione transferase activity
DZA53_RS04065	COG0626	cystathionine gamma-synthase activity
DZA53_RS04085	COG1216	Glycosyl transferase, family 2
DZA53_RS04085	COG0438	transferase activity, transferring glycosyl groups
DZA53_RS04120	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DZA53_RS04125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DZA53_RS04140	COG0277	FAD linked oxidase domain protein
DZA53_RS04145	COG0546	phosphoglycolate phosphatase activity
DZA53_RS04145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DZA53_RS04160	COG2086	electron transfer activity
DZA53_RS04185	COG0662	Cupin 2, conserved barrel domain protein
DZA53_RS04185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DZA53_RS04190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DZA53_RS04230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DZA53_RS04230	COG3218	ABC-type transport auxiliary lipoprotein component
DZA53_RS04235	COG1127	ABC transporter
DZA53_RS04240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DZA53_RS04255	COG0442	prolyl-tRNA aminoacylation
DZA53_RS04265	COG1183	phosphatidylcholine synthase activity
DZA53_RS04300	COG3039	Transposase
DZA53_RS04340	COG3039	Transposase
DZA53_RS04380	COG0525	valine-tRNA ligase activity
DZA53_RS04395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DZA53_RS04405	COG0795	lipopolysaccharide-transporting ATPase activity
DZA53_RS04420	COG4974	Belongs to the 'phage' integrase family
DZA53_RS04425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DZA53_RS04430	COG0047	phosphoribosylformylglycinamidine synthase activity
DZA53_RS04430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DZA53_RS04440	COG5295	Hep Hag repeat protein
DZA53_RS04450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DZA53_RS04460	COG1459	type II secretion system
DZA53_RS04465	COG2165	general secretion pathway protein
DZA53_RS04470	COG4970	Tfp pilus assembly protein FimT
DZA53_RS04475	COG2165	general secretion pathway protein
DZA53_RS04480	COG4795	General secretion pathway protein
DZA53_RS04485	COG3156	type II secretion system protein K
DZA53_RS04490	COG3166	PFAM Fimbrial assembly family protein
DZA53_RS04505	COG1450	Type ii and iii secretion system protein
DZA53_RS04520	COG2188	Transcriptional regulator
DZA53_RS04575	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DZA53_RS04580	COG1518	maintenance of DNA repeat elements
DZA53_RS04625	COG1399	metal-binding, possibly nucleic acid-binding protein
DZA53_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS04655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DZA53_RS04665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DZA53_RS04670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DZA53_RS04705	COG3829	transcription factor binding
DZA53_RS04820	COG2826	transposase and inactivated derivatives, IS30 family
DZA53_RS04830	COG0678	peroxiredoxin activity
DZA53_RS04850	COG0330	HflC and HflK could
DZA53_RS04855	COG0330	HflC and HflK could
DZA53_RS04865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DZA53_RS04870	COG0308	aminopeptidase N
DZA53_RS04920	COG1560	Kdo2-lipid A biosynthetic process
DZA53_RS04925	COG1519	Transferase
DZA53_RS04930	COG1538	Outer membrane efflux protein
DZA53_RS04935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DZA53_RS04965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DZA53_RS04970	COG0066	3-isopropylmalate dehydratase activity
DZA53_RS04975	COG2226	methyltransferase
DZA53_RS05005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DZA53_RS05015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DZA53_RS05020	COG3710	Transcriptional regulator
DZA53_RS05045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DZA53_RS05065	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DZA53_RS05095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DZA53_RS05105	COG3781	membrane
DZA53_RS05265	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DZA53_RS05285	COG1217	gtp-binding protein TYPA
DZA53_RS05290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DZA53_RS05295	COG0039	L-malate dehydrogenase activity
DZA53_RS05300	COG0625	glutathione transferase activity
DZA53_RS05320	COG3039	Transposase
DZA53_RS05350	COG0584	glycerophosphoryl diester phosphodiesterase
DZA53_RS05380	COG0446	pyridine nucleotide-disulphide oxidoreductase
DZA53_RS05380	COG1902	pentaerythritol trinitrate reductase activity
DZA53_RS05385	COG0604	alcohol dehydrogenase
DZA53_RS05415	COG0156	8-amino-7-oxononanoate synthase activity
DZA53_RS05420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DZA53_RS05425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DZA53_RS05430	COG4208	sulfate ABC transporter
DZA53_RS05435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DZA53_RS05480	COG0406	alpha-ribazole phosphatase activity
DZA53_RS05490	COG0285	dihydrofolate synthase activity
DZA53_RS05510	COG2833	Protein of unknown function (DUF455)
DZA53_RS05530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DZA53_RS05535	COG0671	phosphoesterase, PA-phosphatase related
DZA53_RS05540	COG0438	transferase activity, transferring glycosyl groups
DZA53_RS05550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DZA53_RS05565	COG4783	chaperone-mediated protein folding
DZA53_RS05590	COG0473	3-isopropylmalate dehydrogenase activity
DZA53_RS05645	COG0544	peptidyl-prolyl cis-trans isomerase activity
DZA53_RS05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DZA53_RS05720	COG0631	protein serine/threonine phosphatase activity
DZA53_RS05825	COG0582	viral genome integration into host DNA
DZA53_RS05835	COG0859	PFAM glycosyl transferase family 9
DZA53_RS05840	COG3642	lipopolysaccharide core region biosynthetic process
DZA53_RS05845	COG1234	tRNA 3'-trailer cleavage
DZA53_RS05850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DZA53_RS05860	COG0315	cyclic pyranopterin monophosphate synthase activity
DZA53_RS05865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DZA53_RS05870	COG0314	molybdopterin synthase activity
DZA53_RS05900	COG0537	adenosine 5'-monophosphoramidase activity
DZA53_RS05920	COG0714	Associated with various cellular activities
DZA53_RS05940	COG0242	peptide deformylase activity
DZA53_RS05990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DZA53_RS05995	COG0726	polysaccharide deacetylase
DZA53_RS06020	COG1162	GTPase activity
DZA53_RS06045	COG2211	Major facilitator Superfamily
DZA53_RS06055	COG1609	Transcriptional regulator
DZA53_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS06065	COG2851	Citrate transporter
DZA53_RS06085	COG0642	Histidine kinase
DZA53_RS06095	COG2197	response regulator
DZA53_RS06120	COG0583	DNA-binding transcription factor activity
DZA53_RS06135	COG4191	Histidine kinase
DZA53_RS06155	COG0281	malic enzyme
DZA53_RS06155	COG0280	phosphate acetyltransferase
DZA53_RS06190	COG0352	thiamine-phosphate diphosphorylase activity
DZA53_RS06195	COG1773	rubredoxin
DZA53_RS06200	COG2912	Transglutaminase-like superfamily
DZA53_RS06210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DZA53_RS06245	COG0006	proline dipeptidase activity
DZA53_RS06275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DZA53_RS06290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DZA53_RS06295	COG1561	YicC-like family, N-terminal region
DZA53_RS06320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DZA53_RS06330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DZA53_RS06355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DZA53_RS06395	COG0714	Associated with various cellular activities
DZA53_RS06415	COG2304	oxidoreductase activity
DZA53_RS06435	COG1301	dicarboxylic acid transport
DZA53_RS06440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DZA53_RS06450	COG0739	heme binding
DZA53_RS06455	COG1376	ErfK ybiS ycfS ynhG family protein
DZA53_RS06480	COG1022	Amp-dependent synthetase and ligase
DZA53_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS06505	COG0642	Histidine kinase
DZA53_RS06525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DZA53_RS06530	COG4149	molybdate abc transporter
DZA53_RS06535	COG0725	ABC transporter, periplasmic molybdate-binding protein
DZA53_RS06540	COG3453	Protein conserved in bacteria
DZA53_RS06540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DZA53_RS06580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DZA53_RS06600	COG2205	protein histidine kinase activity
DZA53_RS06605	COG3039	Transposase
DZA53_RS06610	COG0745	RESPONSE REGULATOR receiver
DZA53_RS06625	COG3039	Transposase
DZA53_RS06660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DZA53_RS06665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DZA53_RS06725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DZA53_RS06755	COG2201	protein-glutamate methylesterase activity
DZA53_RS06840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DZA53_RS06850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DZA53_RS06855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DZA53_RS06870	COG1842	Phage shock protein A
DZA53_RS06895	COG0754	glutathionylspermidine amidase activity
DZA53_RS06965	COG0531	amino acid
DZA53_RS06970	COG2197	response regulator
DZA53_RS06985	COG1113	amino acid transport
DZA53_RS07005	COG1271	oxidase subunit
DZA53_RS07010	COG1294	oxidase, subunit
DZA53_RS07020	COG2239	Acts as a magnesium transporter
DZA53_RS07030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DZA53_RS07035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DZA53_RS07045	COG1660	Displays ATPase and GTPase activities
DZA53_RS07050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DZA53_RS07055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DZA53_RS07070	COG1137	ATPase activity
DZA53_RS07075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DZA53_RS07085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DZA53_RS07095	COG0271	Belongs to the BolA IbaG family
DZA53_RS07100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DZA53_RS07120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DZA53_RS07135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DZA53_RS07145	COG0628	permease
DZA53_RS07155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DZA53_RS07160	COG3178	'Phosphotransferase
DZA53_RS07175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DZA53_RS07180	COG1555	photosystem II stabilization
DZA53_RS07230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DZA53_RS07240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DZA53_RS07265	COG0228	four-way junction DNA binding
DZA53_RS07270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DZA53_RS07275	COG0336	Belongs to the RNA methyltransferase TrmD family
DZA53_RS07290	COG0534	Mate efflux family protein
DZA53_RS07335	COG0542	response to heat
DZA53_RS07375	COG4206	TonB-dependent receptor
DZA53_RS07435	COG0019	diaminopimelate decarboxylase activity
DZA53_RS07450	COG4264	IucA IucC family
DZA53_RS07460	COG4772	TonB-dependent receptor
DZA53_RS07475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DZA53_RS07475	COG4651	solute:proton antiporter activity
DZA53_RS07505	COG0488	(ABC) transporter
DZA53_RS07530	COG0657	acetylesterase activity
DZA53_RS07530	COG2755	lipolytic protein G-D-S-L family
DZA53_RS07550	COG2207	Transcriptional regulator
DZA53_RS07555	COG0326	Molecular chaperone. Has ATPase activity
DZA53_RS07590	COG0174	glutamine synthetase
DZA53_RS07595	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DZA53_RS07605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DZA53_RS07620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DZA53_RS07650	COG2146	nitrite reductase [NAD(P)H] activity
DZA53_RS07665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DZA53_RS07670	COG0719	Fe-S assembly protein
DZA53_RS07675	COG0396	ATPase activity
DZA53_RS07680	COG0719	Fe-S assembly protein
DZA53_RS07685	COG1959	2 iron, 2 sulfur cluster binding
DZA53_RS07705	COG0693	protein deglycase activity
DZA53_RS07750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DZA53_RS07785	COG0519	Catalyzes the synthesis of GMP from XMP
DZA53_RS07795	COG1678	Uncharacterized ACR, COG1678
DZA53_RS07800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DZA53_RS07815	COG1764	response to oxidative stress
DZA53_RS07825	COG0384	phenazine biosynthesis protein PhzF
DZA53_RS07835	COG0527	aspartate kinase activity
DZA53_RS07865	COG0142	geranyltranstransferase activity
DZA53_RS07870	COG0629	single-stranded DNA binding
DZA53_RS07875	COG3706	GGDEF domain
DZA53_RS07875	COG5001	Diguanylate cyclase
DZA53_RS07875	COG4251	negative regulation of phosphorylation
DZA53_RS07875	COG2203	Gaf domain
DZA53_RS07925	COG2879	small protein
DZA53_RS07930	COG1966	Carbon starvation protein
DZA53_RS07935	COG1741	Belongs to the pirin family
DZA53_RS08005	COG3179	chitinase
DZA53_RS08140	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DZA53_RS08175	COG0732	type I restriction modification DNA specificity domain
DZA53_RS08260	COG0587	DNA-directed DNA polymerase activity
DZA53_RS08280	COG1297	OPT oligopeptide transporter protein
DZA53_RS08305	COG1506	peptidase
DZA53_RS08305	COG0823	Involved in the tonB-independent uptake of proteins
DZA53_RS08325	COG2207	Transcriptional regulator
DZA53_RS08325	COG1917	Cupin 2, conserved barrel domain protein
DZA53_RS08355	COG0753	catalase activity
DZA53_RS08390	COG0126	phosphoglycerate kinase activity
DZA53_RS08400	COG0469	pyruvate kinase activity
DZA53_RS08410	COG3588	fructose-bisphosphate aldolase
DZA53_RS08415	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DZA53_RS08465	COG0784	Response regulator, receiver
DZA53_RS08465	COG2198	Histidine kinase
DZA53_RS08465	COG2205	protein histidine kinase activity
DZA53_RS08490	COG0175	sulfate reduction
DZA53_RS08495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DZA53_RS08500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DZA53_RS08505	COG0175	sulfate reduction
DZA53_RS08510	COG0529	Catalyzes the synthesis of activated sulfate
DZA53_RS08510	COG2895	sulfate adenylyltransferase (ATP) activity
DZA53_RS08515	COG3039	Transposase
DZA53_RS08530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DZA53_RS08535	COG0308	aminopeptidase N
DZA53_RS08565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DZA53_RS08590	COG1970	mechanosensitive ion channel activity
DZA53_RS08620	COG0471	metal ion transport
DZA53_RS08620	COG3273	potassium ion transport
DZA53_RS08635	COG2022	thiamine diphosphate biosynthetic process
DZA53_RS08730	COG3039	Transposase
DZA53_RS08830	COG3118	belongs to the thioredoxin family
DZA53_RS08840	COG0495	leucyl-tRNA aminoacylation
DZA53_RS08860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DZA53_RS08885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DZA53_RS08915	COG2968	Membrane
DZA53_RS08930	COG3164	Protein of unknown function
DZA53_RS08940	COG0312	modulator of DNA gyrase
DZA53_RS08945	COG3028	Belongs to the UPF0307 family
DZA53_RS08950	COG0312	modulator of DNA gyrase
DZA53_RS08975	COG0142	geranyltranstransferase activity
DZA53_RS08980	COG1722	exodeoxyribonuclease VII activity
DZA53_RS08985	COG0037	tRNA processing
DZA53_RS08990	COG1785	Belongs to the alkaline phosphatase family
DZA53_RS08995	COG1301	dicarboxylic acid transport
DZA53_RS09015	COG0791	NLP P60 protein
DZA53_RS09020	COG0791	NLP P60 protein
DZA53_RS09025	COG1047	Peptidyl-prolyl cis-trans
DZA53_RS09030	COG2311	Membrane
DZA53_RS09035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DZA53_RS09080	COG0489	protein tyrosine kinase activity
DZA53_RS09085	COG0717	Belongs to the dCTP deaminase family
DZA53_RS09105	COG0412	Dienelactone hydrolase
DZA53_RS09115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DZA53_RS09170	COG2890	protein-(glutamine-N5) methyltransferase activity
DZA53_RS09175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DZA53_RS09180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DZA53_RS09185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DZA53_RS09205	COG0101	tRNA pseudouridine synthase activity
DZA53_RS09210	COG0135	phosphoribosylanthranilate isomerase activity
DZA53_RS09220	COG0133	tryptophan synthase activity
DZA53_RS09230	COG0159	tryptophan synthase activity
DZA53_RS09240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DZA53_RS09245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DZA53_RS09300	COG0149	triose-phosphate isomerase activity
DZA53_RS09315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DZA53_RS09325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DZA53_RS09330	COG0649	NAD binding
DZA53_RS09335	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DZA53_RS09340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DZA53_RS09345	COG1034	ATP synthesis coupled electron transport
DZA53_RS09350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DZA53_RS09380	COG1007	ATP synthesis coupled electron transport
DZA53_RS09390	COG0779	Required for maturation of 30S ribosomal subunits
DZA53_RS09395	COG0195	Participates in both transcription termination and antitermination
DZA53_RS09400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DZA53_RS09415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DZA53_RS09420	COG1185	polyribonucleotide nucleotidyltransferase activity
DZA53_RS09455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DZA53_RS09465	COG2095	MarC family integral membrane protein
DZA53_RS09480	COG1611	Belongs to the LOG family
DZA53_RS09520	COG4969	Belongs to the N-Me-Phe pilin family
DZA53_RS09525	COG0556	nucleotide-excision repair
DZA53_RS09565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DZA53_RS09575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DZA53_RS09580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DZA53_RS09635	COG0438	transferase activity, transferring glycosyl groups
DZA53_RS09640	COG0438	transferase activity, transferring glycosyl groups
DZA53_RS09650	COG0438	transferase activity, transferring glycosyl groups
DZA53_RS09690	COG3040	lipid binding
DZA53_RS09785	COG4191	Histidine kinase
DZA53_RS09785	COG0784	Response regulator, receiver
DZA53_RS09810	COG0552	protein localization to endoplasmic reticulum
DZA53_RS09820	COG3938	Belongs to the proline racemase family
DZA53_RS09825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DZA53_RS09840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DZA53_RS09850	COG0006	proline dipeptidase activity
DZA53_RS09865	COG0531	amino acid
DZA53_RS09915	COG4206	TonB-dependent receptor
DZA53_RS10005	COG0746	molybdenum cofactor guanylyltransferase activity
DZA53_RS10030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DZA53_RS10030	COG1648	precorrin-2 dehydrogenase activity
DZA53_RS10075	COG3039	Transposase
DZA53_RS10080	COG3039	Transposase
DZA53_RS10125	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DZA53_RS10145	COG1054	Belongs to the UPF0176 family
DZA53_RS10165	COG1530	ribonuclease E activity
DZA53_RS10175	COG3064	Membrane
DZA53_RS10180	COG0428	transporter
DZA53_RS10185	COG0428	transporter
DZA53_RS10195	COG2154	pterin-4-alpha-carbinolamine dehydratase
DZA53_RS10200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DZA53_RS10200	COG0316	Belongs to the HesB IscA family
DZA53_RS10350	COG0632	four-way junction helicase activity
DZA53_RS10360	COG2255	four-way junction helicase activity
DZA53_RS10365	COG0824	Thioesterase
DZA53_RS10375	COG0848	biopolymer transport protein
DZA53_RS10385	COG0823	Involved in the tonB-independent uptake of proteins
DZA53_RS10390	COG2885	chlorophyll binding
DZA53_RS10400	COG0602	queuosine metabolic process
DZA53_RS10425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DZA53_RS10450	COG0514	ATP-dependent DNA helicase (RecQ)
DZA53_RS10460	COG0783	Belongs to the Dps family
DZA53_RS10465	COG1643	Atp-dependent helicase
DZA53_RS10490	COG0535	radical SAM domain protein
DZA53_RS10495	COG0535	radical SAM domain protein
DZA53_RS10500	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DZA53_RS10515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DZA53_RS10525	COG1215	transferase activity, transferring glycosyl groups
DZA53_RS10530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DZA53_RS10540	COG1199	ATP-dependent helicase activity
DZA53_RS10550	COG1397	ADP-ribosylglycohydrolase
DZA53_RS10560	COG0189	ligase activity
DZA53_RS10575	COG0835	chemotaxis
DZA53_RS10580	COG0840	transmembrane signaling receptor activity
DZA53_RS10585	COG0643	Histidine kinase
DZA53_RS10585	COG0784	Response regulator, receiver
DZA53_RS10585	COG2198	Histidine kinase
DZA53_RS10640	COG1446	asparaginase
DZA53_RS10690	COG3537	Alpha-1,2-mannosidase
DZA53_RS10765	COG1472	Belongs to the glycosyl hydrolase 3 family
DZA53_RS10785	COG3858	chitin binding
DZA53_RS10785	COG1388	LysM domain
DZA53_RS10800	COG0837	glucose binding
DZA53_RS10805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DZA53_RS10815	COG0494	nUDIX hydrolase
DZA53_RS10825	COG3956	TIGRFAM MazG family protein
DZA53_RS10840	COG0330	HflC and HflK could
DZA53_RS10855	COG0509	glycine decarboxylation via glycine cleavage system
DZA53_RS10890	COG1960	acyl-CoA dehydrogenase activity
DZA53_RS10900	COG1309	transcriptional regulator
DZA53_RS10905	COG4771	TonB-dependent receptor
DZA53_RS10915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DZA53_RS10925	COG0463	Glycosyl transferase, family 2
DZA53_RS10955	COG1272	protein, Hemolysin III
DZA53_RS10960	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DZA53_RS10965	COG0739	heme binding
DZA53_RS10970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DZA53_RS10975	COG0626	cystathionine gamma-synthase activity
DZA53_RS10985	COG1760	l-serine dehydratase
DZA53_RS11000	COG2353	YceI-like domain
DZA53_RS11010	COG2353	YceI-like domain
DZA53_RS11080	COG1960	acyl-CoA dehydrogenase activity
DZA53_RS11085	COG1024	Enoyl-CoA hydratase
DZA53_RS11105	COG1024	Enoyl-CoA hydratase
DZA53_RS11105	COG1250	3-hydroxyacyl-CoA dehydrogenase
DZA53_RS11120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DZA53_RS11150	COG1381	Involved in DNA repair and RecF pathway recombination
DZA53_RS11165	COG2954	triphosphatase activity
DZA53_RS11185	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DZA53_RS11190	COG3046	protein related to deoxyribodipyrimidine photolyase
DZA53_RS11200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DZA53_RS11205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DZA53_RS11210	COG1278	Cold shock
DZA53_RS11230	COG1201	RNA secondary structure unwinding
DZA53_RS11235	COG1793	dna ligase
DZA53_RS11245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DZA53_RS11245	COG1793	dna ligase
DZA53_RS11275	COG0183	Belongs to the thiolase family
DZA53_RS11300	COG1451	nucleotide metabolic process
DZA53_RS11315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DZA53_RS11320	COG3039	Transposase
DZA53_RS11355	COG1047	Peptidyl-prolyl cis-trans
DZA53_RS11370	COG2824	Alkylphosphonate utilization operon protein PhnA
DZA53_RS11385	COG1902	pentaerythritol trinitrate reductase activity
DZA53_RS11390	COG2814	Major facilitator Superfamily
DZA53_RS11435	COG0392	lysyltransferase activity
DZA53_RS11435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DZA53_RS11445	COG0251	oxidation-reduction process
DZA53_RS11450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DZA53_RS11465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DZA53_RS11490	COG1595	DNA-templated transcription, initiation
DZA53_RS11510	COG2878	Part of a membrane complex involved in electron transport
DZA53_RS11520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DZA53_RS11520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DZA53_RS11540	COG0833	amino acid
DZA53_RS11545	COG2040	homocysteine
DZA53_RS11565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DZA53_RS11610	COG2895	sulfate adenylyltransferase (ATP) activity
DZA53_RS11610	COG0529	Catalyzes the synthesis of activated sulfate
DZA53_RS11655	COG1981	membrane
DZA53_RS11680	COG1131	(ABC) transporter
DZA53_RS11685	COG4771	TonB-dependent receptor
DZA53_RS11695	COG0825	malonyl-CoA metabolic process
DZA53_RS11715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DZA53_RS11720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DZA53_RS11740	COG0750	zinc metalloprotease
DZA53_RS11750	COG0575	Belongs to the CDS family
DZA53_RS11760	COG0233	cytoplasmic translational termination
DZA53_RS11775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DZA53_RS11835	COG1393	Belongs to the ArsC family
DZA53_RS11845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DZA53_RS11850	COG0367	asparagine synthase
DZA53_RS11860	COG4774	siderophore transport
DZA53_RS11890	COG2207	Transcriptional regulator
DZA53_RS11905	COG1566	PFAM secretion protein HlyD family protein
DZA53_RS11910	COG2814	Major facilitator Superfamily
DZA53_RS11955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DZA53_RS11965	COG1960	acyl-CoA dehydrogenase activity
DZA53_RS11980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DZA53_RS11990	COG2914	Belongs to the UPF0125 (RnfH) family
DZA53_RS12000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DZA53_RS12010	COG0497	DNA recombination
DZA53_RS12020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DZA53_RS12030	COG0484	heat shock protein binding
DZA53_RS12040	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DZA53_RS12045	COG0287	Prephenate dehydrogenase
DZA53_RS12045	COG1605	Chorismate mutase
DZA53_RS12065	COG0583	DNA-binding transcription factor activity
DZA53_RS12080	COG1132	(ABC) transporter
DZA53_RS12115	COG2850	peptidyl-arginine hydroxylation
DZA53_RS12160	COG3039	Transposase
DZA53_RS12200	COG1131	(ABC) transporter
DZA53_RS12205	COG1725	Transcriptional regulator
DZA53_RS12215	COG0386	Belongs to the glutathione peroxidase family
DZA53_RS12230	COG2900	Belongs to the SlyX family
DZA53_RS12245	COG1609	Transcriptional regulator
DZA53_RS12255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DZA53_RS12265	COG0646	methionine synthase
DZA53_RS12265	COG1410	methionine synthase
DZA53_RS12270	COG1410	methionine synthase
DZA53_RS12270	COG0646	methionine synthase
DZA53_RS12275	COG2226	methyltransferase
DZA53_RS12280	COG1960	acyl-CoA dehydrogenase activity
DZA53_RS12320	COG0557	exoribonuclease II activity
DZA53_RS12335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DZA53_RS12350	COG3039	Transposase
DZA53_RS12390	COG3328	transposase activity
DZA53_RS12400	COG1278	Cold shock
DZA53_RS12485	COG3039	Transposase
DZA53_RS12495	COG0583	DNA-binding transcription factor activity
DZA53_RS12560	COG3209	COG3209 Rhs family protein
DZA53_RS12630	COG0643	Histidine kinase
DZA53_RS12630	COG0784	Response regulator, receiver
DZA53_RS12630	COG2198	Histidine kinase
DZA53_RS12685	COG1684	flagellar biosynthetic protein fliR
DZA53_RS12705	COG3190	flagellar
DZA53_RS12755	COG1677	Flagellar hook-basal body complex protein FliE
DZA53_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS12815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DZA53_RS12835	COG2201	protein-glutamate methylesterase activity
DZA53_RS12865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DZA53_RS12870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DZA53_RS12910	COG4787	bacterial-type flagellum-dependent cell motility
DZA53_RS12920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DZA53_RS12925	COG1558	bacterial-type flagellum-dependent cell motility
DZA53_RS12935	COG0835	chemotaxis
DZA53_RS12935	COG0784	Response regulator, receiver
DZA53_RS12955	COG5002	protein histidine kinase activity
DZA53_RS12965	COG4585	Histidine kinase
DZA53_RS12970	COG5001	Diguanylate cyclase
DZA53_RS12995	COG0482	sulfurtransferase activity
DZA53_RS13010	COG0542	response to heat
DZA53_RS13035	COG0492	ferredoxin-NADP+ reductase activity
DZA53_RS13040	COG1674	ftsk spoiiie
DZA53_RS13065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DZA53_RS13085	COG0038	chloride channel
DZA53_RS13090	COG0183	Belongs to the thiolase family
DZA53_RS13095	COG1250	3-hydroxyacyl-CoA dehydrogenase
DZA53_RS13095	COG1024	Enoyl-CoA hydratase
DZA53_RS13110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DZA53_RS13120	COG1426	Protein conserved in bacteria
DZA53_RS13130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DZA53_RS13140	COG0303	'Molybdopterin
DZA53_RS13220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DZA53_RS13230	COG3039	Transposase
DZA53_RS13260	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DZA53_RS13265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DZA53_RS13270	COG0235	Class ii aldolase
DZA53_RS13275	COG0531	amino acid
DZA53_RS13280	COG0531	amino acid
DZA53_RS13290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DZA53_RS13295	COG0277	FAD linked oxidase domain protein
DZA53_RS13360	COG0436	Aminotransferase
DZA53_RS13385	COG1187	pseudouridine synthase activity
DZA53_RS13390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DZA53_RS13395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DZA53_RS13400	COG2350	Protein conserved in bacteria
DZA53_RS13430	COG1175	transmembrane transport
DZA53_RS13435	COG0395	ABC-type sugar transport system, permease component
DZA53_RS13460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DZA53_RS13470	COG2957	Belongs to the agmatine deiminase family
DZA53_RS13485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DZA53_RS13490	COG0539	negative regulation of cytoplasmic translation
DZA53_RS13495	COG0776	regulation of translation
DZA53_RS13505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DZA53_RS13510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DZA53_RS13520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DZA53_RS13540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DZA53_RS13555	COG3002	Belongs to the UPF0753 family
DZA53_RS13560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DZA53_RS13565	COG0583	DNA-binding transcription factor activity
DZA53_RS13595	COG0583	DNA-binding transcription factor activity
DZA53_RS13620	COG1914	H( )-stimulated, divalent metal cation uptake system
DZA53_RS13640	COG0668	transmembrane transport
DZA53_RS13665	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS13670	COG1183	phosphatidylcholine synthase activity
DZA53_RS13680	COG3243	poly(R)-hydroxyalkanoic acid synthase
DZA53_RS13695	COG0723	plastoquinol--plastocyanin reductase activity
DZA53_RS13695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DZA53_RS13705	COG2183	response to ionizing radiation
DZA53_RS13720	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DZA53_RS13735	COG0671	phosphoesterase, PA-phosphatase related
DZA53_RS13760	COG1794	racemase activity, acting on amino acids and derivatives
DZA53_RS13770	COG0697	spore germination
DZA53_RS13795	COG1012	belongs to the aldehyde dehydrogenase family
DZA53_RS13840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DZA53_RS13860	COG0124	histidyl-tRNA synthetase
DZA53_RS13890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DZA53_RS13905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DZA53_RS13905	COG0131	Imidazoleglycerol-phosphate dehydratase
DZA53_RS13915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DZA53_RS13925	COG0140	phosphoribosyl-ATP diphosphatase activity
DZA53_RS13925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DZA53_RS14020	COG0653	protein targeting
DZA53_RS14060	COG2801	Transposase and inactivated derivatives
DZA53_RS14080	COG3328	transposase activity
DZA53_RS14115	COG0322	excinuclease ABC activity
DZA53_RS14125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DZA53_RS14135	COG1663	tetraacyldisaccharide 4'-kinase activity
DZA53_RS14150	COG0811	peptide transport
DZA53_RS14175	COG4591	ABC-type transport system involved in lipoprotein release permease component
DZA53_RS14190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DZA53_RS14205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DZA53_RS14220	COG0354	folic acid binding
DZA53_RS14235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DZA53_RS14245	COG0363	glucosamine-6-phosphate deaminase activity
DZA53_RS14250	COG0129	dihydroxy-acid dehydratase activity
DZA53_RS14255	COG0800	Aldolase
DZA53_RS14290	COG0784	Response regulator, receiver
DZA53_RS14290	COG2205	protein histidine kinase activity
DZA53_RS14290	COG5002	protein histidine kinase activity
DZA53_RS14335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DZA53_RS14340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DZA53_RS14345	COG0431	NADPH-dependent FMN reductase
DZA53_RS14350	COG1393	Belongs to the ArsC family
DZA53_RS14355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DZA53_RS14370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DZA53_RS14400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DZA53_RS14425	COG1247	-acetyltransferase
DZA53_RS14505	COG0386	Belongs to the glutathione peroxidase family
DZA53_RS14595	COG5001	Diguanylate cyclase
DZA53_RS14595	COG4251	negative regulation of phosphorylation
DZA53_RS14595	COG3706	GGDEF domain
DZA53_RS14595	COG2203	Gaf domain
DZA53_RS14615	COG1472	Belongs to the glycosyl hydrolase 3 family
DZA53_RS14640	COG0166	Belongs to the GPI family
DZA53_RS14650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DZA53_RS14655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DZA53_RS14665	COG0617	tRNA 3'-terminal CCA addition
DZA53_RS14675	COG1469	GTP cyclohydrolase I activity
DZA53_RS14680	COG0860	N-Acetylmuramoyl-L-alanine amidase
DZA53_RS14735	COG4566	intracellular signal transduction
DZA53_RS14775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DZA53_RS14780	COG1605	Chorismate mutase
DZA53_RS14780	COG0077	Prephenate dehydratase
DZA53_RS14785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DZA53_RS14790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DZA53_RS14835	COG1228	amidohydrolase
DZA53_RS14840	COG2986	histidine ammonia-lyase
DZA53_RS14850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DZA53_RS14875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DZA53_RS14890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DZA53_RS14905	COG3115	cell septum assembly
DZA53_RS14915	COG0359	binds to the 23S rRNA
DZA53_RS14925	COG0360	Binds together with S18 to 16S ribosomal RNA
DZA53_RS14930	COG0316	Belongs to the HesB IscA family
DZA53_RS14965	COG0288	reversible hydration of carbon dioxide
DZA53_RS14985	COG3844	kynureninase activity
DZA53_RS14995	COG2925	Exonuclease
DZA53_RS15005	COG0667	Aldo Keto reductase
DZA53_RS15030	COG0116	Belongs to the methyltransferase superfamily
DZA53_RS15030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DZA53_RS15075	COG0494	nUDIX hydrolase
DZA53_RS15085	COG1024	Enoyl-CoA hydratase
DZA53_RS15095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DZA53_RS15130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DZA53_RS15135	COG0573	inorganic phosphate transmembrane transporter activity
DZA53_RS15150	COG0704	Plays a role in the regulation of phosphate uptake
DZA53_RS15160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DZA53_RS15180	COG3328	transposase activity
DZA53_RS15210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DZA53_RS15215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DZA53_RS15220	COG1862	Preprotein translocase
DZA53_RS15225	COG0343	queuine tRNA-ribosyltransferase activity
DZA53_RS15265	COG3039	Transposase
DZA53_RS15340	COG0405	Gamma-glutamyltransferase
DZA53_RS15345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DZA53_RS15360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DZA53_RS15365	COG0742	ribosomal rna small subunit methyltransferase
DZA53_RS15470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DZA53_RS15475	COG4988	ABC transporter
DZA53_RS15485	COG1271	oxidase subunit
DZA53_RS15515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DZA53_RS15535	COG0165	Argininosuccinate lyase
DZA53_RS15550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DZA53_RS15555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DZA53_RS15565	COG0137	argininosuccinate synthase activity
DZA53_RS15570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DZA53_RS15585	COG2166	iron-sulfur cluster assembly
DZA53_RS15610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DZA53_RS15645	COG3039	Transposase
DZA53_RS15670	COG4677	pectinesterase activity
DZA53_RS15695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DZA53_RS15700	COG0402	S-adenosylhomocysteine deaminase activity
DZA53_RS15715	COG1509	lysine 2,3-aminomutase activity
DZA53_RS15720	COG3300	MHYT domain
DZA53_RS15720	COG5001	Diguanylate cyclase
DZA53_RS15735	COG0483	inositol monophosphate 1-phosphatase activity
DZA53_RS15740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DZA53_RS15765	COG0488	(ABC) transporter
DZA53_RS15770	COG0513	Belongs to the DEAD box helicase family
DZA53_RS15775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DZA53_RS15790	COG0625	glutathione transferase activity
DZA53_RS15800	COG1671	Belongs to the UPF0178 family
DZA53_RS15805	COG4681	YaeQ
DZA53_RS15810	COG2081	HI0933 family
DZA53_RS15820	COG0501	Belongs to the peptidase M48B family
DZA53_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS15855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DZA53_RS15860	COG0860	N-Acetylmuramoyl-L-alanine amidase
DZA53_RS15865	COG0802	atpase or kinase
DZA53_RS15870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DZA53_RS15870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DZA53_RS15875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DZA53_RS15895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DZA53_RS15980	COG3328	transposase activity
DZA53_RS16025	COG2969	positive regulation of protein catabolic process
DZA53_RS16030	COG0625	glutathione transferase activity
DZA53_RS16035	COG2857	Cytochrome c1
DZA53_RS16040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DZA53_RS16045	COG0723	plastoquinol--plastocyanin reductase activity
DZA53_RS16055	COG0741	lytic transglycosylase activity
DZA53_RS16080	COG1702	phosphate starvation-inducible protein PhoH
DZA53_RS16100	COG4535	Mg2 and Co2 transporter CorC
DZA53_RS16115	COG1012	belongs to the aldehyde dehydrogenase family
DZA53_RS16125	COG1177	transmembrane transport
DZA53_RS16180	COG0174	glutamine synthetase
DZA53_RS16185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DZA53_RS16195	COG0477	Major facilitator Superfamily
DZA53_RS16210	COG0243	molybdopterin cofactor binding
DZA53_RS16220	COG2223	nitrite transmembrane transporter activity
DZA53_RS16230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DZA53_RS16235	COG1121	(ABC) transporter
DZA53_RS16245	COG2733	membrane
DZA53_RS16250	COG5002	protein histidine kinase activity
DZA53_RS16250	COG2205	protein histidine kinase activity
DZA53_RS16250	COG0784	Response regulator, receiver
DZA53_RS16260	COG3039	Transposase
DZA53_RS16270	COG2902	Dehydrogenase
DZA53_RS16280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DZA53_RS16285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DZA53_RS16305	COG1609	Transcriptional regulator
DZA53_RS16310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DZA53_RS16310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DZA53_RS16315	COG1105	Belongs to the carbohydrate kinase PfkB family
DZA53_RS16320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DZA53_RS16320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DZA53_RS16335	COG3039	Transposase
DZA53_RS16345	COG3039	Transposase
DZA53_RS16370	COG3039	Transposase
DZA53_RS16480	COG4771	TonB-dependent receptor
DZA53_RS16490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DZA53_RS16510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DZA53_RS16515	COG1360	Flagellar Motor Protein
DZA53_RS16525	COG0835	chemotaxis
DZA53_RS16535	COG0745	RESPONSE REGULATOR receiver
DZA53_RS16560	COG0840	transmembrane signaling receptor activity
DZA53_RS16575	COG0840	transmembrane signaling receptor activity
DZA53_RS16585	COG0840	transmembrane signaling receptor activity
DZA53_RS16595	COG0840	transmembrane signaling receptor activity
DZA53_RS16600	COG0840	transmembrane signaling receptor activity
DZA53_RS16605	COG0840	transmembrane signaling receptor activity
DZA53_RS16610	COG0840	transmembrane signaling receptor activity
DZA53_RS16635	COG0835	chemotaxis
DZA53_RS16660	COG0840	transmembrane signaling receptor activity
DZA53_RS16695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DZA53_RS16725	COG0318	PFAM AMP-dependent synthetase and ligase
DZA53_RS16730	COG1024	Enoyl-CoA hydratase
DZA53_RS16735	COG2198	Histidine kinase
DZA53_RS16735	COG2205	protein histidine kinase activity
DZA53_RS16735	COG0784	Response regulator, receiver
DZA53_RS16750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DZA53_RS16810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DZA53_RS16820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DZA53_RS16825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DZA53_RS16835	COG0505	Belongs to the CarA family
DZA53_RS16840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DZA53_RS16850	COG2258	MOSC domain
DZA53_RS16855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DZA53_RS16905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DZA53_RS16925	COG0477	Major facilitator Superfamily
DZA53_RS16935	COG1070	Carbohydrate kinase
DZA53_RS16945	COG1501	Belongs to the glycosyl hydrolase 31 family
DZA53_RS16960	COG0800	Aldolase
DZA53_RS16965	COG4948	Mandelate Racemase Muconate Lactonizing
DZA53_RS16975	COG3734	2-keto-3-deoxy-galactonokinase
DZA53_RS16980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DZA53_RS16990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DZA53_RS17005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DZA53_RS17010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DZA53_RS17020	COG0351	phosphomethylpyrimidine kinase
DZA53_RS17050	COG0583	DNA-binding transcription factor activity
DZA53_RS17055	COG1741	Belongs to the pirin family
DZA53_RS17080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DZA53_RS17085	COG0305	Participates in initiation and elongation during chromosome replication
DZA53_RS17105	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DZA53_RS17110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DZA53_RS17115	COG2137	regulation of response to DNA damage stimulus
DZA53_RS17120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DZA53_RS17135	COG1546	Belongs to the CinA family
DZA53_RS17140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DZA53_RS17150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DZA53_RS17155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DZA53_RS17165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DZA53_RS17170	COG1534	Rna-binding protein
DZA53_RS17185	COG1238	metal cluster binding
DZA53_RS17190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DZA53_RS17195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DZA53_RS17200	COG2840	Smr protein MutS2
DZA53_RS17215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DZA53_RS17225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DZA53_RS17230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DZA53_RS17235	COG0148	phosphopyruvate hydratase activity
DZA53_RS17245	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DZA53_RS17250	COG0504	CTP synthase activity
DZA53_RS17280	COG0306	phosphate transporter
DZA53_RS17295	COG1253	flavin adenine dinucleotide binding
DZA53_RS17310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DZA53_RS17330	COG0477	Major facilitator Superfamily
DZA53_RS17340	COG1132	(ABC) transporter
DZA53_RS17345	COG1136	(ABC) transporter
DZA53_RS17360	COG0438	transferase activity, transferring glycosyl groups
DZA53_RS17370	COG2264	protein methyltransferase activity
DZA53_RS17400	COG2244	polysaccharide biosynthetic process
DZA53_RS17450	COG1595	DNA-templated transcription, initiation
DZA53_RS17465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DZA53_RS17485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DZA53_RS17535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DZA53_RS17540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DZA53_RS17595	COG1858	cytochrome C peroxidase
DZA53_RS17625	COG0515	serine threonine protein kinase
DZA53_RS17630	COG0631	protein serine/threonine phosphatase activity
DZA53_RS17730	COG3039	Transposase
DZA53_RS17780	COG3039	Transposase
DZA53_RS17805	COG3039	Transposase
DZA53_RS17830	COG3039	Transposase
DZA53_RS17835	COG3209	COG3209 Rhs family protein
DZA53_RS17835	COG3209	COG3209 Rhs family protein
DZA53_RS17875	COG3209	COG3209 Rhs family protein
DZA53_RS17875	COG3209	COG3209 Rhs family protein
DZA53_RS17895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DZA53_RS17900	COG1845	cytochrome c oxidase, subunit III
DZA53_RS17905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DZA53_RS17920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DZA53_RS17925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DZA53_RS17935	COG0196	riboflavin kinase activity
DZA53_RS17940	COG0728	peptidoglycan biosynthetic process
DZA53_RS17945	COG0268	Binds directly to 16S ribosomal RNA
DZA53_RS17950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DZA53_RS17955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DZA53_RS17965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DZA53_RS17970	COG0824	Thioesterase
DZA53_RS17985	COG1946	Acyl-CoA thioesterase
DZA53_RS17995	COG1595	DNA-templated transcription, initiation
DZA53_RS18010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DZA53_RS18050	COG1877	trehalose-phosphatase activity
DZA53_RS18055	COG3387	PFAM Glycoside hydrolase 15-related
DZA53_RS18080	COG0564	pseudouridine synthase activity
DZA53_RS18085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DZA53_RS18090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DZA53_RS18090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DZA53_RS18100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DZA53_RS18105	COG0045	succinate-CoA ligase (ADP-forming) activity
DZA53_RS18125	COG2184	nucleotidyltransferase activity
DZA53_RS18145	COG2194	sulfuric ester hydrolase activity
DZA53_RS18150	COG4969	Belongs to the N-Me-Phe pilin family
DZA53_RS18160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DZA53_RS18215	COG3039	Transposase
DZA53_RS18225	COG3209	COG3209 Rhs family protein
DZA53_RS18265	COG1132	(ABC) transporter
DZA53_RS18295	COG0745	RESPONSE REGULATOR receiver
DZA53_RS18300	COG5000	phosphorelay sensor kinase activity
DZA53_RS18300	COG5002	protein histidine kinase activity
DZA53_RS18305	COG0475	glutathione-regulated potassium exporter activity
DZA53_RS18315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DZA53_RS18340	COG1187	pseudouridine synthase activity
DZA53_RS18345	COG5001	Diguanylate cyclase
DZA53_RS18345	COG5002	protein histidine kinase activity
DZA53_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS18465	COG0415	Belongs to the DNA photolyase family
DZA53_RS18470	COG0305	Participates in initiation and elongation during chromosome replication
DZA53_RS18480	COG0367	asparagine synthase
DZA53_RS18495	COG1960	acyl-CoA dehydrogenase activity
DZA53_RS18510	COG0084	hydrolase, TatD family'
DZA53_RS18515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DZA53_RS18575	COG0735	belongs to the Fur family
DZA53_RS18580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DZA53_RS18595	COG3039	Transposase
DZA53_RS18620	COG3039	Transposase
DZA53_RS18660	COG3039	Transposase
DZA53_RS18700	COG2205	protein histidine kinase activity
DZA53_RS18715	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DZA53_RS18725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DZA53_RS18740	COG0643	Histidine kinase
DZA53_RS18740	COG2198	Histidine kinase
DZA53_RS18750	COG0840	transmembrane signaling receptor activity
DZA53_RS18755	COG0835	chemotaxis
DZA53_RS18760	COG2199	diguanylate cyclase activity
DZA53_RS18760	COG2200	EAL domain
DZA53_RS18760	COG2202	Pas domain
DZA53_RS18765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DZA53_RS18780	COG3590	peptidase
DZA53_RS18795	COG0588	phosphoglycerate mutase activity
DZA53_RS18800	COG1515	deoxyribonuclease V activity
DZA53_RS18810	COG1741	Belongs to the pirin family
DZA53_RS18835	COG3039	Transposase
DZA53_RS18850	COG3039	Transposase
DZA53_RS18885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DZA53_RS18965	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DZA53_RS18990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DZA53_RS19005	COG2197	response regulator
DZA53_RS19010	COG4585	Histidine kinase
DZA53_RS19030	COG2894	cell division
DZA53_RS19035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DZA53_RS19045	COG0642	Histidine kinase
DZA53_RS19050	COG0745	RESPONSE REGULATOR receiver
DZA53_RS19055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DZA53_RS19065	COG2194	sulfuric ester hydrolase activity
DZA53_RS19095	COG3551	Protein conserved in bacteria
DZA53_RS19160	COG0203	ribosomal protein L17
DZA53_RS19170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DZA53_RS19175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DZA53_RS19185	COG0201	protein transport
DZA53_RS19195	COG1841	ribosomal large subunit assembly
DZA53_RS19205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DZA53_RS19225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DZA53_RS19230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DZA53_RS19235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DZA53_RS19240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DZA53_RS19245	COG0255	Belongs to the universal ribosomal protein uL29 family
DZA53_RS19250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DZA53_RS19260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DZA53_RS19275	COG0089	rRNA binding
DZA53_RS19280	COG0088	Forms part of the polypeptide exit tunnel
DZA53_RS19285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DZA53_RS19290	COG0051	transcription antitermination factor activity, RNA binding
DZA53_RS19310	COG0049	tRNA binding
DZA53_RS19315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DZA53_RS19320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DZA53_RS19325	COG0085	RNA polymerase activity
DZA53_RS19330	COG0222	ribosome binding
DZA53_RS19335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DZA53_RS19340	COG0081	regulation of translation
DZA53_RS19345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DZA53_RS19355	COG0250	Participates in transcription elongation, termination and antitermination
DZA53_RS19360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DZA53_RS19390	COG0012	GTP binding
DZA53_RS19395	COG0193	aminoacyl-tRNA hydrolase activity
DZA53_RS19405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DZA53_RS19420	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DZA53_RS19430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DZA53_RS19435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DZA53_RS19445	COG0521	Mo-molybdopterin cofactor biosynthetic process
DZA53_RS19465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DZA53_RS19470	COG1295	ribonuclease BN
DZA53_RS19500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DZA53_RS19505	COG1404	Belongs to the peptidase S8 family
DZA53_RS19520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DZA53_RS19550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DZA53_RS19575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DZA53_RS19590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DZA53_RS19590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DZA53_RS19630	COG2890	protein-(glutamine-N5) methyltransferase activity
DZA53_RS19640	COG3634	alkyl hydroperoxide reductase activity
DZA53_RS19645	COG0583	DNA-binding transcription factor activity
DZA53_RS19655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DZA53_RS19660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DZA53_RS19690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DZA53_RS19810	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DZA53_RS19820	COG3386	PFAM SMP-30 Gluconolaconase
DZA53_RS19840	COG1024	Enoyl-CoA hydratase
DZA53_RS19850	COG0318	PFAM AMP-dependent synthetase and ligase
DZA53_RS19855	COG0583	DNA-binding transcription factor activity
DZA53_RS19895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DZA53_RS19900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DZA53_RS19910	COG2096	Adenosyltransferase
DZA53_RS19915	COG0123	including yeast histone deacetylase and acetoin utilization protein
DZA53_RS19930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DZA53_RS19940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DZA53_RS19945	COG2967	ApaG domain
DZA53_RS19970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DZA53_RS19990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DZA53_RS20010	COG0642	Histidine kinase
DZA53_RS20025	COG4181	ATPase activity
DZA53_RS20035	COG2175	clavaminate synthase activity
DZA53_RS20085	COG0667	Aldo Keto reductase
DZA53_RS20095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DZA53_RS20100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DZA53_RS20115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DZA53_RS20130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DZA53_RS20180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DZA53_RS20185	COG2226	methyltransferase
DZA53_RS20240	COG0604	alcohol dehydrogenase
DZA53_RS20240	COG3321	synthase
DZA53_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS20255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DZA53_RS20270	COG0494	nUDIX hydrolase
DZA53_RS20280	COG0653	protein targeting
DZA53_RS20285	COG1388	LysM domain
DZA53_RS20285	COG4942	peptidase
DZA53_RS20295	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DZA53_RS20310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DZA53_RS20315	COG1181	Belongs to the D-alanine--D-alanine ligase family
DZA53_RS20320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DZA53_RS20335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DZA53_RS20340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DZA53_RS20355	COG3116	cell division
DZA53_RS20360	COG0275	rRNA processing
DZA53_RS20395	COG0792	nuclease activity
DZA53_RS20400	COG1988	membrane-bound metal-dependent
DZA53_RS20405	COG0277	FAD linked oxidase domain protein
DZA53_RS20410	COG0745	RESPONSE REGULATOR receiver
DZA53_RS20415	COG2205	protein histidine kinase activity
DZA53_RS20425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DZA53_RS20430	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DZA53_RS20455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DZA53_RS20460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DZA53_RS20465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DZA53_RS20485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DZA53_RS20485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DZA53_RS20505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DZA53_RS20525	COG0488	(ABC) transporter
DZA53_RS20580	COG2205	protein histidine kinase activity
DZA53_RS20625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DZA53_RS20660	COG3039	Transposase
DZA53_RS20675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DZA53_RS20760	COG3039	Transposase
DZA53_RS20815	COG1649	PFAM Uncharacterised BCR, COG1649
DZA53_RS20815	COG0726	polysaccharide deacetylase
DZA53_RS20820	COG1215	transferase activity, transferring glycosyl groups
DZA53_RS20830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DZA53_RS20835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DZA53_RS20840	COG1609	Transcriptional regulator
DZA53_RS20850	COG2188	Transcriptional regulator
DZA53_RS20865	COG3250	beta-galactosidase activity
DZA53_RS20915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DZA53_RS20920	COG4191	Histidine kinase
DZA53_RS20925	COG0784	Response regulator, receiver
DZA53_RS20930	COG4251	negative regulation of phosphorylation
DZA53_RS20935	COG2823	Periplasmic or secreted lipoprotein
DZA53_RS20940	COG0673	inositol 2-dehydrogenase activity
DZA53_RS20945	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DZA53_RS20980	COG1051	belongs to the nudix hydrolase family
DZA53_RS20980	COG1056	cytidyltransferase-related domain
DZA53_RS21005	COG2921	Belongs to the UPF0250 family
DZA53_RS21020	COG1686	Belongs to the peptidase S11 family
DZA53_RS21025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DZA53_RS21030	COG2951	lytic endotransglycosylase activity
DZA53_RS21050	COG3409	Peptidoglycan-binding domain 1 protein
DZA53_RS21050	COG5632	N-Acetylmuramoyl-L-alanine amidase
DZA53_RS21050	COG1388	LysM domain
DZA53_RS21080	COG0772	Belongs to the SEDS family
DZA53_RS21095	COG1792	Involved in formation and maintenance of cell shape
DZA53_RS21100	COG1077	Cell shape determining protein MreB Mrl
DZA53_RS21105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DZA53_RS21150	COG2199	diguanylate cyclase activity
DZA53_RS21155	COG0308	aminopeptidase N
DZA53_RS21185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DZA53_RS21215	COG0436	Aminotransferase
DZA53_RS21230	COG1505	serine-type exopeptidase activity
DZA53_RS21255	COG0181	hydroxymethylbilane synthase activity
DZA53_RS21265	COG3275	phosphorelay sensor kinase activity
DZA53_RS21320	COG0659	secondary active sulfate transmembrane transporter activity
DZA53_RS21325	COG5297	Belongs to the glycosyl hydrolase family 6
DZA53_RS21325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DZA53_RS21390	COG3039	Transposase
DZA53_RS21410	COG0598	Magnesium transport protein CorA
DZA53_RS21420	COG1113	amino acid transport
DZA53_RS21430	COG5297	Belongs to the glycosyl hydrolase family 6
DZA53_RS21435	COG4305	rare lipoprotein A
DZA53_RS21440	COG0697	spore germination
DZA53_RS21500	COG4221	oxidoreductase activity
DZA53_RS21530	COG0456	acetyltransferase
DZA53_RS21540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DZA53_RS21585	COG2111	Na H antiporter
DZA53_RS21585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DZA53_RS21590	COG1006	Multisubunit Na H antiporter MnhC subunit
DZA53_RS21595	COG0651	ATP synthesis coupled electron transport
DZA53_RS21605	COG2212	antiporter activity
DZA53_RS21610	COG1320	monovalent cation:proton antiporter activity
DZA53_RS21625	COG3039	Transposase
DZA53_RS21630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DZA53_RS21650	COG3104	oligopeptide transport
DZA53_RS21655	COG3483	tryptophan 2,3-dioxygenase activity
DZA53_RS21665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DZA53_RS21700	COG0183	Belongs to the thiolase family
DZA53_RS21775	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DZA53_RS21780	COG3023	N-Acetylmuramoyl-L-alanine amidase
DZA53_RS21790	COG4948	Mandelate Racemase Muconate Lactonizing
DZA53_RS21825	COG0531	amino acid
DZA53_RS21855	COG4682	membrane
DZA53_RS21860	COG2133	pyrroloquinoline quinone binding
DZA53_RS21900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DZA53_RS21905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DZA53_RS21915	COG1610	YqeY-like protein
DZA53_RS21935	COG1295	ribonuclease BN
DZA53_RS21940	COG0358	DNA primase activity
DZA53_RS22095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DZA53_RS22105	COG1560	Kdo2-lipid A biosynthetic process
DZA53_RS22155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DZA53_RS22155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DZA53_RS22160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DZA53_RS22165	COG0242	peptide deformylase activity
DZA53_RS22170	COG1652	LysM domain
DZA53_RS22175	COG0758	DNA mediated transformation
DZA53_RS22180	COG2922	Belongs to the Smg family
DZA53_RS22195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DZA53_RS22195	COG1754	DNA topoisomerase type I activity
DZA53_RS22200	COG0009	L-threonylcarbamoyladenylate synthase
DZA53_RS22215	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS22225	COG0616	signal peptide processing
DZA53_RS22230	COG0534	Mate efflux family protein
DZA53_RS22255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DZA53_RS22290	COG1324	tolerance protein
DZA53_RS22310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DZA53_RS22315	COG0511	ligase activity, forming carbon-carbon bonds
DZA53_RS22325	COG0439	Biotin carboxylase
DZA53_RS22385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DZA53_RS22470	COG2831	hemolysin activation secretion protein
DZA53_RS22500	COG2267	carboxylic ester hydrolase activity
DZA53_RS22510	COG2267	carboxylic ester hydrolase activity
DZA53_RS22520	COG0138	bifunctional purine biosynthesis protein purh
DZA53_RS22530	COG0151	Belongs to the GarS family
DZA53_RS22535	COG0577	efflux transmembrane transporter activity
DZA53_RS22535	COG1136	(ABC) transporter
DZA53_RS22545	COG1289	transmembrane transporter activity
DZA53_RS22560	COG2814	Major facilitator Superfamily
DZA53_RS22585	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DZA53_RS22620	COG0745	RESPONSE REGULATOR receiver
DZA53_RS22670	COG0739	heme binding
DZA53_RS22690	COG2211	Major facilitator Superfamily
DZA53_RS22695	COG0708	Exodeoxyribonuclease III
DZA53_RS22710	COG1192	Involved in chromosome partitioning
DZA53_RS22715	COG1475	DNA binding
DZA53_RS22730	COG0463	Glycosyl transferase, family 2
DZA53_RS22750	COG0756	dUTP diphosphatase activity
DZA53_RS22755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DZA53_RS22760	COG2003	Belongs to the UPF0758 family
DZA53_RS22765	COG0018	arginyl-trna synthetase
DZA53_RS22780	COG4221	oxidoreductase activity
DZA53_RS22805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DZA53_RS22810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DZA53_RS22825	COG3485	protocatechuate 3,4-dioxygenase
DZA53_RS22830	COG3485	protocatechuate 3,4-dioxygenase
DZA53_RS22870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DZA53_RS22880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DZA53_RS22895	COG0045	succinate-CoA ligase (ADP-forming) activity
DZA53_RS22895	COG1042	CoA-binding domain protein
DZA53_RS22895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DZA53_RS22905	COG2239	Acts as a magnesium transporter
DZA53_RS22925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DZA53_RS22945	COG3100	YcgL domain-containing protein
DZA53_RS22950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DZA53_RS22960	COG0463	Glycosyl transferase, family 2
DZA53_RS22975	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS22990	COG0156	8-amino-7-oxononanoate synthase activity
DZA53_RS22995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DZA53_RS23000	COG1040	competence protein
DZA53_RS23005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DZA53_RS23020	COG0628	permease
DZA53_RS23030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DZA53_RS23040	COG1595	DNA-templated transcription, initiation
DZA53_RS23045	COG0753	catalase activity
DZA53_RS23095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DZA53_RS23100	COG0180	Tryptophanyl-tRNA synthetase
DZA53_RS23105	COG3237	CsbD-like
DZA53_RS23145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DZA53_RS23160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DZA53_RS23165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DZA53_RS23165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DZA53_RS23205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DZA53_RS23235	COG1566	PFAM secretion protein HlyD family protein
DZA53_RS23255	COG1199	ATP-dependent helicase activity
DZA53_RS23290	COG0583	DNA-binding transcription factor activity
DZA53_RS23340	COG0625	glutathione transferase activity
DZA53_RS23375	COG4555	ABC transporter
DZA53_RS23385	COG1476	TRANSCRIPTIONal
DZA53_RS23410	COG1131	(ABC) transporter
DZA53_RS23415	COG0842	Transport permease protein
DZA53_RS23425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DZA53_RS23510	COG1181	Belongs to the D-alanine--D-alanine ligase family
DZA53_RS23525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DZA53_RS23535	COG0564	pseudouridine synthase activity
DZA53_RS23565	COG0339	signal peptide processing
DZA53_RS23595	COG3254	rhamnose metabolic process
DZA53_RS23600	COG0738	Major facilitator superfamily
DZA53_RS23605	COG1414	Transcriptional regulator
DZA53_RS23620	COG2205	protein histidine kinase activity
DZA53_RS23630	COG3459	Glycosyltransferase 36 associated
DZA53_RS23635	COG2211	Major facilitator Superfamily
DZA53_RS23640	COG3265	gluconokinase activity
DZA53_RS23650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DZA53_RS23740	COG1127	ABC transporter
DZA53_RS23745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DZA53_RS23750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DZA53_RS23765	COG2853	Lipoprotein
DZA53_RS23790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DZA53_RS23855	COG0676	glucose-6-phosphate 1-epimerase activity
DZA53_RS23880	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DZA53_RS23890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DZA53_RS23900	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DZA53_RS23910	COG1064	alcohol dehydrogenase
DZA53_RS23955	COG1522	sequence-specific DNA binding
DZA53_RS23960	COG3186	Phenylalanine-4-hydroxylase
DZA53_RS23975	COG2755	lipolytic protein G-D-S-L family
DZA53_RS24000	COG0656	L-ascorbic acid biosynthetic process
DZA53_RS24005	COG2130	NADP-dependent
DZA53_RS24010	COG0667	Aldo Keto reductase
DZA53_RS24020	COG1187	pseudouridine synthase activity
DZA53_RS24035	COG1643	Atp-dependent helicase
DZA53_RS24040	COG4807	Protein conserved in bacteria
DZA53_RS24045	COG4948	Mandelate Racemase Muconate Lactonizing
DZA53_RS24055	COG0179	Fumarylacetoacetate (FAA) hydrolase
DZA53_RS24060	COG1028	Short-chain dehydrogenase reductase Sdr
DZA53_RS24080	COG3507	Belongs to the glycosyl hydrolase 43 family
DZA53_RS24120	COG3162	membrane
DZA53_RS24125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DZA53_RS24140	COG0708	Exodeoxyribonuclease III
DZA53_RS24155	COG2091	lysine biosynthetic process via aminoadipic acid
DZA53_RS24165	COG3540	Alkaline phosphatase
DZA53_RS24170	COG0357	Ribosomal RNA small subunit methyltransferase G
DZA53_RS24190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DZA53_RS24195	COG2159	amidohydrolase
DZA53_RS24210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DZA53_RS24215	COG0583	DNA-binding transcription factor activity
DZA53_RS24220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DZA53_RS24240	COG0210	DNA helicase
DZA53_RS24255	COG0531	amino acid
DZA53_RS24270	COG1322	Protein conserved in bacteria
DZA53_RS24285	COG0386	Belongs to the glutathione peroxidase family
DZA53_RS24340	COG0793	Belongs to the peptidase S41A family
DZA53_RS24345	COG4942	peptidase
DZA53_RS24355	COG2234	aminopeptidase activity
DZA53_RS24405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DZA53_RS24410	COG0302	gtp cyclohydrolase
DZA53_RS24430	COG0477	Major facilitator Superfamily
DZA53_RS24440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DZA53_RS24515	COG1192	Involved in chromosome partitioning
DZA53_RS24550	COG1929	Belongs to the glycerate kinase type-1 family
DZA53_RS24555	COG2271	Major facilitator Superfamily
DZA53_RS24570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DZA53_RS24580	COG0861	Integral membrane protein TerC family
DZA53_RS24590	COG0584	glycerophosphoryl diester phosphodiesterase
DZA53_RS24600	COG0671	phosphoesterase, PA-phosphatase related
DZA53_RS24605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DZA53_RS24610	COG0726	polysaccharide deacetylase
DZA53_RS24615	COG0706	membrane insertase activity