locus-tag	class	description
GKO49_RS00115	COG3039	Transposase
GKO49_RS00120	COG0513	Belongs to the DEAD box helicase family
GKO49_RS00185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_RS00190	COG3265	gluconokinase activity
GKO49_RS00195	COG2211	Major facilitator Superfamily
GKO49_RS00200	COG3459	Glycosyltransferase 36 associated
GKO49_RS00210	COG2205	protein histidine kinase activity
GKO49_RS00225	COG1414	Transcriptional regulator
GKO49_RS00230	COG0738	Major facilitator superfamily
GKO49_RS00235	COG3254	rhamnose metabolic process
GKO49_RS00265	COG0339	signal peptide processing
GKO49_RS00295	COG0564	pseudouridine synthase activity
GKO49_RS00305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GKO49_RS00315	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKO49_RS00380	COG3551	Protein conserved in bacteria
GKO49_RS00410	COG2194	sulfuric ester hydrolase activity
GKO49_RS00420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GKO49_RS00425	COG0745	RESPONSE REGULATOR receiver
GKO49_RS00430	COG0642	Histidine kinase
GKO49_RS00440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GKO49_RS00445	COG2894	cell division
GKO49_RS00465	COG4585	Histidine kinase
GKO49_RS00470	COG2197	response regulator
GKO49_RS00485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GKO49_RS00515	COG2963	transposase activity
GKO49_RS00630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKO49_RS00685	COG0408	coproporphyrinogen oxidase activity
GKO49_RS00705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GKO49_RS00710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GKO49_RS00715	COG2350	Protein conserved in bacteria
GKO49_RS00755	COG1175	transmembrane transport
GKO49_RS00760	COG0395	ABC-type sugar transport system, permease component
GKO49_RS00785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKO49_RS00795	COG2957	Belongs to the agmatine deiminase family
GKO49_RS00810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKO49_RS00815	COG0539	negative regulation of cytoplasmic translation
GKO49_RS00820	COG0776	regulation of translation
GKO49_RS00830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GKO49_RS00835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKO49_RS00845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GKO49_RS00865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GKO49_RS00880	COG3002	Belongs to the UPF0753 family
GKO49_RS00885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GKO49_RS00890	COG0583	DNA-binding transcription factor activity
GKO49_RS00920	COG0583	DNA-binding transcription factor activity
GKO49_RS00940	COG1914	H( )-stimulated, divalent metal cation uptake system
GKO49_RS00960	COG0668	transmembrane transport
GKO49_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS01010	COG1183	phosphatidylcholine synthase activity
GKO49_RS01020	COG3243	poly(R)-hydroxyalkanoic acid synthase
GKO49_RS01035	COG0723	plastoquinol--plastocyanin reductase activity
GKO49_RS01035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKO49_RS01045	COG2183	response to ionizing radiation
GKO49_RS01060	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GKO49_RS01075	COG0671	phosphoesterase, PA-phosphatase related
GKO49_RS01165	COG1247	-acetyltransferase
GKO49_RS01200	COG0343	queuine tRNA-ribosyltransferase activity
GKO49_RS01205	COG1862	Preprotein translocase
GKO49_RS01210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKO49_RS01215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKO49_RS01245	COG4206	TonB-dependent receptor
GKO49_RS01310	COG0019	diaminopimelate decarboxylase activity
GKO49_RS01320	COG2814	Major facilitator Superfamily
GKO49_RS01325	COG4264	IucA IucC family
GKO49_RS01335	COG4772	TonB-dependent receptor
GKO49_RS01350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GKO49_RS01350	COG4651	solute:proton antiporter activity
GKO49_RS01375	COG0488	(ABC) transporter
GKO49_RS01400	COG2755	lipolytic protein G-D-S-L family
GKO49_RS01400	COG0657	acetylesterase activity
GKO49_RS01415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GKO49_RS01430	COG2040	homocysteine
GKO49_RS01435	COG0833	amino acid
GKO49_RS01455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKO49_RS01455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKO49_RS01465	COG2878	Part of a membrane complex involved in electron transport
GKO49_RS01480	COG1595	DNA-templated transcription, initiation
GKO49_RS01505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKO49_RS01520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKO49_RS01525	COG0251	oxidation-reduction process
GKO49_RS01535	COG0392	lysyltransferase activity
GKO49_RS01535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GKO49_RS01575	COG2814	Major facilitator Superfamily
GKO49_RS01580	COG1902	pentaerythritol trinitrate reductase activity
GKO49_RS01590	COG2824	Alkylphosphonate utilization operon protein PhnA
GKO49_RS01610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKO49_RS01670	COG0303	'Molybdopterin
GKO49_RS01675	COG1160	GTP binding
GKO49_RS01680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_RS01690	COG1426	Protein conserved in bacteria
GKO49_RS01700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GKO49_RS01715	COG1024	Enoyl-CoA hydratase
GKO49_RS01715	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKO49_RS01720	COG0183	Belongs to the thiolase family
GKO49_RS01730	COG0038	chloride channel
GKO49_RS01750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GKO49_RS01770	COG1674	ftsk spoiiie
GKO49_RS01775	COG0492	ferredoxin-NADP+ reductase activity
GKO49_RS01800	COG0542	response to heat
GKO49_RS01815	COG0482	sulfurtransferase activity
GKO49_RS01840	COG5001	Diguanylate cyclase
GKO49_RS01845	COG4585	Histidine kinase
GKO49_RS01855	COG5002	protein histidine kinase activity
GKO49_RS01875	COG0835	chemotaxis
GKO49_RS01875	COG0784	Response regulator, receiver
GKO49_RS01885	COG1558	bacterial-type flagellum-dependent cell motility
GKO49_RS01890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GKO49_RS01900	COG4787	bacterial-type flagellum-dependent cell motility
GKO49_RS01940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GKO49_RS01945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GKO49_RS01975	COG2201	protein-glutamate methylesterase activity
GKO49_RS01995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKO49_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS02040	COG1677	Flagellar hook-basal body complex protein FliE
GKO49_RS02090	COG3190	flagellar
GKO49_RS02105	COG1684	flagellar biosynthetic protein fliR
GKO49_RS02160	COG0784	Response regulator, receiver
GKO49_RS02160	COG0643	Histidine kinase
GKO49_RS02160	COG2198	Histidine kinase
GKO49_RS02190	COG3209	COG3209 Rhs family protein
GKO49_RS02285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GKO49_RS02290	COG4988	ABC transporter
GKO49_RS02310	COG4677	pectinesterase activity
GKO49_RS02325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKO49_RS02335	COG1609	Transcriptional regulator
GKO49_RS02350	COG2900	Belongs to the SlyX family
GKO49_RS02365	COG0386	Belongs to the glutathione peroxidase family
GKO49_RS02375	COG1725	Transcriptional regulator
GKO49_RS02380	COG1131	(ABC) transporter
GKO49_RS02460	COG2850	peptidyl-arginine hydroxylation
GKO49_RS02495	COG1132	(ABC) transporter
GKO49_RS02510	COG0583	DNA-binding transcription factor activity
GKO49_RS02525	COG1605	Chorismate mutase
GKO49_RS02525	COG0287	Prephenate dehydrogenase
GKO49_RS02530	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GKO49_RS02535	COG0484	heat shock protein binding
GKO49_RS02545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GKO49_RS02555	COG0497	DNA recombination
GKO49_RS02565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_RS02570	COG2914	Belongs to the UPF0125 (RnfH) family
GKO49_RS02580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GKO49_RS02595	COG1960	acyl-CoA dehydrogenase activity
GKO49_RS02605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GKO49_RS02650	COG2814	Major facilitator Superfamily
GKO49_RS02655	COG1566	PFAM secretion protein HlyD family protein
GKO49_RS02695	COG4774	siderophore transport
GKO49_RS02705	COG0367	asparagine synthase
GKO49_RS02720	COG1393	Belongs to the ArsC family
GKO49_RS02785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GKO49_RS02800	COG0233	cytoplasmic translational termination
GKO49_RS02810	COG0575	Belongs to the CDS family
GKO49_RS02820	COG0750	zinc metalloprotease
GKO49_RS02845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GKO49_RS02850	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GKO49_RS02870	COG0825	malonyl-CoA metabolic process
GKO49_RS02880	COG4771	TonB-dependent receptor
GKO49_RS02910	COG1981	membrane
GKO49_RS03040	COG0745	RESPONSE REGULATOR receiver
GKO49_RS03045	COG0277	FAD linked oxidase domain protein
GKO49_RS03050	COG1988	membrane-bound metal-dependent
GKO49_RS03055	COG0792	nuclease activity
GKO49_RS03090	COG0275	rRNA processing
GKO49_RS03095	COG3116	cell division
GKO49_RS03110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GKO49_RS03115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKO49_RS03130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKO49_RS03135	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKO49_RS03140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GKO49_RS03155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GKO49_RS03165	COG4942	peptidase
GKO49_RS03165	COG1388	LysM domain
GKO49_RS03170	COG0653	protein targeting
GKO49_RS03180	COG0494	nUDIX hydrolase
GKO49_RS03195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GKO49_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS03205	COG3321	synthase
GKO49_RS03205	COG0604	alcohol dehydrogenase
GKO49_RS03260	COG2226	methyltransferase
GKO49_RS03265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GKO49_RS03300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GKO49_RS03315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GKO49_RS03325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKO49_RS03330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GKO49_RS03340	COG0667	Aldo Keto reductase
GKO49_RS03385	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GKO49_RS03395	COG2175	clavaminate synthase activity
GKO49_RS03405	COG4181	ATPase activity
GKO49_RS03420	COG0642	Histidine kinase
GKO49_RS03440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GKO49_RS03460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GKO49_RS03485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GKO49_RS03490	COG2967	ApaG domain
GKO49_RS03495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GKO49_RS03505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GKO49_RS03520	COG0123	including yeast histone deacetylase and acetoin utilization protein
GKO49_RS03525	COG2096	Adenosyltransferase
GKO49_RS03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKO49_RS03540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKO49_RS03560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKO49_RS03615	COG1966	Carbon starvation protein
GKO49_RS03620	COG2879	small protein
GKO49_RS03655	COG2203	Gaf domain
GKO49_RS03655	COG5001	Diguanylate cyclase
GKO49_RS03655	COG4251	negative regulation of phosphorylation
GKO49_RS03655	COG3706	GGDEF domain
GKO49_RS03660	COG0629	single-stranded DNA binding
GKO49_RS03665	COG0142	geranyltranstransferase activity
GKO49_RS03690	COG0527	aspartate kinase activity
GKO49_RS03700	COG0384	phenazine biosynthesis protein PhzF
GKO49_RS03705	COG3039	Transposase
GKO49_RS03715	COG1764	response to oxidative stress
GKO49_RS03730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GKO49_RS03735	COG1678	Uncharacterized ACR, COG1678
GKO49_RS03745	COG0519	Catalyzes the synthesis of GMP from XMP
GKO49_RS03775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GKO49_RS03815	COG0693	protein deglycase activity
GKO49_RS03835	COG1959	2 iron, 2 sulfur cluster binding
GKO49_RS03840	COG0719	Fe-S assembly protein
GKO49_RS03845	COG0396	ATPase activity
GKO49_RS03850	COG0719	Fe-S assembly protein
GKO49_RS03855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GKO49_RS03865	COG2146	nitrite reductase [NAD(P)H] activity
GKO49_RS03895	COG2207	Transcriptional regulator
GKO49_RS03900	COG0326	Molecular chaperone. Has ATPase activity
GKO49_RS03925	COG3328	transposase activity
GKO49_RS03935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GKO49_RS03945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GKO49_RS03960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GKO49_RS03995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GKO49_RS04035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKO49_RS04035	COG3453	Protein conserved in bacteria
GKO49_RS04040	COG0725	ABC transporter, periplasmic molybdate-binding protein
GKO49_RS04045	COG4149	molybdate abc transporter
GKO49_RS04050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GKO49_RS04070	COG0642	Histidine kinase
GKO49_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS04095	COG1022	Amp-dependent synthetase and ligase
GKO49_RS04125	COG1376	ErfK ybiS ycfS ynhG family protein
GKO49_RS04130	COG0739	heme binding
GKO49_RS04140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GKO49_RS04145	COG1301	dicarboxylic acid transport
GKO49_RS04165	COG2304	oxidoreductase activity
GKO49_RS04185	COG0714	Associated with various cellular activities
GKO49_RS04235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GKO49_RS04260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GKO49_RS04270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKO49_RS04295	COG1561	YicC-like family, N-terminal region
GKO49_RS04300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GKO49_RS04315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GKO49_RS04345	COG0006	proline dipeptidase activity
GKO49_RS04370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GKO49_RS04380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GKO49_RS04390	COG2912	Transglutaminase-like superfamily
GKO49_RS04395	COG1773	rubredoxin
GKO49_RS04400	COG0352	thiamine-phosphate diphosphorylase activity
GKO49_RS04425	COG0281	malic enzyme
GKO49_RS04425	COG0280	phosphate acetyltransferase
GKO49_RS04445	COG4191	Histidine kinase
GKO49_RS04460	COG0583	DNA-binding transcription factor activity
GKO49_RS04475	COG2197	response regulator
GKO49_RS04485	COG0642	Histidine kinase
GKO49_RS04500	COG2851	Citrate transporter
GKO49_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS04510	COG1609	Transcriptional regulator
GKO49_RS04545	COG1162	GTPase activity
GKO49_RS04570	COG0726	polysaccharide deacetylase
GKO49_RS04575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GKO49_RS04620	COG0242	peptide deformylase activity
GKO49_RS04640	COG0714	Associated with various cellular activities
GKO49_RS04660	COG0537	adenosine 5'-monophosphoramidase activity
GKO49_RS04690	COG0314	molybdopterin synthase activity
GKO49_RS04695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GKO49_RS04700	COG0315	cyclic pyranopterin monophosphate synthase activity
GKO49_RS04710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GKO49_RS04715	COG1234	tRNA 3'-trailer cleavage
GKO49_RS04720	COG3642	lipopolysaccharide core region biosynthetic process
GKO49_RS04725	COG0859	PFAM glycosyl transferase family 9
GKO49_RS04735	COG0582	viral genome integration into host DNA
GKO49_RS04770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_RS04820	COG1858	cytochrome C peroxidase
GKO49_RS04850	COG0515	serine threonine protein kinase
GKO49_RS04855	COG0631	protein serine/threonine phosphatase activity
GKO49_RS04970	COG3039	Transposase
GKO49_RS05000	COG0473	3-isopropylmalate dehydrogenase activity
GKO49_RS05005	COG1877	trehalose-phosphatase activity
GKO49_RS05010	COG3387	PFAM Glycoside hydrolase 15-related
GKO49_RS05035	COG0564	pseudouridine synthase activity
GKO49_RS05040	COG0564	pseudouridine synthase activity
GKO49_RS05065	COG3387	PFAM Glycoside hydrolase 15-related
GKO49_RS05070	COG1877	trehalose-phosphatase activity
GKO49_RS05110	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GKO49_RS05125	COG1595	DNA-templated transcription, initiation
GKO49_RS05135	COG1946	Acyl-CoA thioesterase
GKO49_RS05150	COG0824	Thioesterase
GKO49_RS05155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GKO49_RS05165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GKO49_RS05170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GKO49_RS05175	COG0268	Binds directly to 16S ribosomal RNA
GKO49_RS05180	COG0728	peptidoglycan biosynthetic process
GKO49_RS05185	COG0196	riboflavin kinase activity
GKO49_RS05195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GKO49_RS05200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GKO49_RS05215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GKO49_RS05220	COG1845	cytochrome c oxidase, subunit III
GKO49_RS05225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GKO49_RS05250	COG0137	argininosuccinate synthase activity
GKO49_RS05260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKO49_RS05265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GKO49_RS05280	COG0165	Argininosuccinate lyase
GKO49_RS05300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GKO49_RS05330	COG1271	oxidase subunit
GKO49_RS05355	COG3273	potassium ion transport
GKO49_RS05355	COG0471	metal ion transport
GKO49_RS05365	COG2022	thiamine diphosphate biosynthetic process
GKO49_RS05415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_RS05415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_RS05435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GKO49_RS05440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKO49_RS05445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GKO49_RS05465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GKO49_RS05470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKO49_RS05475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GKO49_RS05495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_RS05495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_RS05515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GKO49_RS05545	COG1846	Transcriptional regulator
GKO49_RS05550	COG1764	response to oxidative stress
GKO49_RS05635	COG3549	Plasmid maintenance system killer
GKO49_RS05645	COG1074	ATP-dependent DNA helicase activity
GKO49_RS05650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GKO49_RS05695	COG2032	superoxide dismutase activity
GKO49_RS05700	COG2032	superoxide dismutase activity
GKO49_RS05705	COG2204	response regulator
GKO49_RS05710	COG3852	Histidine kinase
GKO49_RS05715	COG0004	ammonium transporteR
GKO49_RS05720	COG0347	Belongs to the P(II) protein family
GKO49_RS05725	COG0174	glutamine synthetase
GKO49_RS05730	COG1968	undecaprenyl-diphosphatase activity
GKO49_RS05775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_RS05785	COG2062	phosphohistidine phosphatase, SixA
GKO49_RS05790	COG0489	protein tyrosine kinase activity
GKO49_RS05815	COG1396	sequence-specific DNA binding
GKO49_RS05820	COG3550	peptidyl-serine autophosphorylation
GKO49_RS05825	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GKO49_RS05830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKO49_RS05845	COG0517	IMP dehydrogenase activity
GKO49_RS05845	COG1125	glycine betaine transport
GKO49_RS05860	COG1119	ATPase activity
GKO49_RS05870	COG1752	Esterase of the alpha-beta hydrolase superfamily
GKO49_RS05910	COG2937	Belongs to the GPAT DAPAT family
GKO49_RS05945	COG0284	orotidine-5'-phosphate decarboxylase activity
GKO49_RS05950	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GKO49_RS05955	COG3132	Protein of unknown function, DUF480
GKO49_RS05970	COG0210	DNA helicase
GKO49_RS05985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GKO49_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS06035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GKO49_RS06105	COG3039	Transposase
GKO49_RS06110	COG3039	Transposase
GKO49_RS06135	COG0316	Belongs to the HesB IscA family
GKO49_RS06135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GKO49_RS06140	COG2154	pterin-4-alpha-carbinolamine dehydratase
GKO49_RS06150	COG0428	transporter
GKO49_RS06155	COG0428	transporter
GKO49_RS06160	COG3064	Membrane
GKO49_RS06170	COG1530	ribonuclease E activity
GKO49_RS06185	COG1054	Belongs to the UPF0176 family
GKO49_RS06205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GKO49_RS06240	COG3039	Transposase
GKO49_RS06275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKO49_RS06275	COG1648	precorrin-2 dehydrogenase activity
GKO49_RS06300	COG0746	molybdenum cofactor guanylyltransferase activity
GKO49_RS06325	COG3039	Transposase
GKO49_RS06375	COG4206	TonB-dependent receptor
GKO49_RS06425	COG0531	amino acid
GKO49_RS06440	COG0006	proline dipeptidase activity
GKO49_RS06450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKO49_RS06465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKO49_RS06470	COG3938	Belongs to the proline racemase family
GKO49_RS06480	COG0552	protein localization to endoplasmic reticulum
GKO49_RS06500	COG0784	Response regulator, receiver
GKO49_RS06500	COG4191	Histidine kinase
GKO49_RS06600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GKO49_RS06615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKO49_RS06650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GKO49_RS06650	COG0140	phosphoribosyl-ATP diphosphatase activity
GKO49_RS06660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GKO49_RS06670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GKO49_RS06670	COG0131	Imidazoleglycerol-phosphate dehydratase
GKO49_RS06685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GKO49_RS06715	COG0124	histidyl-tRNA synthetase
GKO49_RS06735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GKO49_RS06775	COG1012	belongs to the aldehyde dehydrogenase family
GKO49_RS06800	COG0697	spore germination
GKO49_RS06805	COG1794	racemase activity, acting on amino acids and derivatives
GKO49_RS06825	COG0386	Belongs to the glutathione peroxidase family
GKO49_RS06910	COG5001	Diguanylate cyclase
GKO49_RS06910	COG4251	negative regulation of phosphorylation
GKO49_RS06910	COG3706	GGDEF domain
GKO49_RS06910	COG2203	Gaf domain
GKO49_RS06930	COG1472	Belongs to the glycosyl hydrolase 3 family
GKO49_RS06960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKO49_RS06965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GKO49_RS06975	COG0617	tRNA 3'-terminal CCA addition
GKO49_RS06985	COG1469	GTP cyclohydrolase I activity
GKO49_RS06990	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKO49_RS07020	COG1132	(ABC) transporter
GKO49_RS07040	COG0436	Aminotransferase
GKO49_RS07045	COG4133	protoheme IX ABC transporter activity
GKO49_RS07060	COG4133	protoheme IX ABC transporter activity
GKO49_RS07065	COG0436	Aminotransferase
GKO49_RS07105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_RS07110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GKO49_RS07110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKO49_RS07120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GKO49_RS07125	COG0045	succinate-CoA ligase (ADP-forming) activity
GKO49_RS07165	COG2194	sulfuric ester hydrolase activity
GKO49_RS07170	COG4969	Belongs to the N-Me-Phe pilin family
GKO49_RS07180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GKO49_RS07200	COG0542	response to heat
GKO49_RS07235	COG0534	Mate efflux family protein
GKO49_RS07250	COG0336	Belongs to the RNA methyltransferase TrmD family
GKO49_RS07255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GKO49_RS07260	COG0228	four-way junction DNA binding
GKO49_RS07285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GKO49_RS07295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKO49_RS07340	COG1555	photosystem II stabilization
GKO49_RS07345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKO49_RS07360	COG3178	'Phosphotransferase
GKO49_RS07365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GKO49_RS07375	COG0628	permease
GKO49_RS07385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GKO49_RS07400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GKO49_RS07420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKO49_RS07430	COG0271	Belongs to the BolA IbaG family
GKO49_RS07440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GKO49_RS07450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GKO49_RS07455	COG1137	ATPase activity
GKO49_RS07470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKO49_RS07475	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GKO49_RS07480	COG1660	Displays ATPase and GTPase activities
GKO49_RS07495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKO49_RS07500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKO49_RS07505	COG2239	Acts as a magnesium transporter
GKO49_RS07515	COG1294	oxidase, subunit
GKO49_RS07520	COG1271	oxidase subunit
GKO49_RS07540	COG1113	amino acid transport
GKO49_RS07555	COG2197	response regulator
GKO49_RS07560	COG0531	amino acid
GKO49_RS07630	COG0754	glutathionylspermidine amidase activity
GKO49_RS07655	COG1842	Phage shock protein A
GKO49_RS07670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GKO49_RS07675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GKO49_RS07685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GKO49_RS07745	COG3039	Transposase
GKO49_RS07765	COG1294	oxidase, subunit
GKO49_RS07770	COG1271	oxidase subunit
GKO49_RS07820	COG2972	Histidine kinase
GKO49_RS07835	COG0531	amino acid
GKO49_RS07855	COG3590	peptidase
GKO49_RS07865	COG0667	Aldo Keto reductase
GKO49_RS07880	COG3384	dioxygenase
GKO49_RS07890	COG1573	uracil-dna glycosylase
GKO49_RS07900	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GKO49_RS07915	COG0025	NhaP-type Na H and K H
GKO49_RS07920	COG1131	(ABC) transporter
GKO49_RS07925	COG0842	Transport permease protein
GKO49_RS07945	COG1404	Belongs to the peptidase S8 family
GKO49_RS07960	COG0745	RESPONSE REGULATOR receiver
GKO49_RS08010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKO49_RS08035	COG2202	Pas domain
GKO49_RS08035	COG2205	protein histidine kinase activity
GKO49_RS08065	COG2813	Specifically methylates the guanine in position
GKO49_RS08070	COG1187	pseudouridine synthase activity
GKO49_RS08075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKO49_RS08110	COG0697	spore germination
GKO49_RS08120	COG2011	ABC-type metal ion transport system permease component
GKO49_RS08150	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKO49_RS08160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKO49_RS08180	COG0356	it plays a direct role in the translocation of protons across the membrane
GKO49_RS08190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GKO49_RS08200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GKO49_RS08205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GKO49_RS08210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GKO49_RS08260	COG1970	mechanosensitive ion channel activity
GKO49_RS08325	COG2197	response regulator
GKO49_RS08430	COG3386	PFAM SMP-30 Gluconolaconase
GKO49_RS08450	COG1024	Enoyl-CoA hydratase
GKO49_RS08460	COG0318	PFAM AMP-dependent synthetase and ligase
GKO49_RS08465	COG0583	DNA-binding transcription factor activity
GKO49_RS08515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKO49_RS08560	COG1228	amidohydrolase
GKO49_RS08565	COG2986	histidine ammonia-lyase
GKO49_RS08575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GKO49_RS08600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GKO49_RS08615	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GKO49_RS08630	COG3115	cell septum assembly
GKO49_RS08640	COG0359	binds to the 23S rRNA
GKO49_RS08650	COG0360	Binds together with S18 to 16S ribosomal RNA
GKO49_RS08655	COG0316	Belongs to the HesB IscA family
GKO49_RS08685	COG0288	reversible hydration of carbon dioxide
GKO49_RS08715	COG2925	Exonuclease
GKO49_RS08725	COG0667	Aldo Keto reductase
GKO49_RS08750	COG0116	Belongs to the methyltransferase superfamily
GKO49_RS08750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GKO49_RS08795	COG0494	nUDIX hydrolase
GKO49_RS08805	COG1024	Enoyl-CoA hydratase
GKO49_RS08815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GKO49_RS08850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GKO49_RS08855	COG0573	inorganic phosphate transmembrane transporter activity
GKO49_RS08870	COG0704	Plays a role in the regulation of phosphate uptake
GKO49_RS08880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GKO49_RS08915	COG2205	protein histidine kinase activity
GKO49_RS08930	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GKO49_RS08940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GKO49_RS08955	COG2198	Histidine kinase
GKO49_RS08955	COG0643	Histidine kinase
GKO49_RS08960	COG0840	transmembrane signaling receptor activity
GKO49_RS08965	COG0835	chemotaxis
GKO49_RS08970	COG2199	diguanylate cyclase activity
GKO49_RS08970	COG2202	Pas domain
GKO49_RS08970	COG2200	EAL domain
GKO49_RS08975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GKO49_RS08990	COG3590	peptidase
GKO49_RS09005	COG0588	phosphoglycerate mutase activity
GKO49_RS09010	COG1515	deoxyribonuclease V activity
GKO49_RS09020	COG1741	Belongs to the pirin family
GKO49_RS09060	COG1205	dead DEAH box helicase
GKO49_RS09060	COG1111	helicase
GKO49_RS09065	COG1272	protein, Hemolysin III
GKO49_RS09185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKO49_RS09205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKO49_RS09220	COG1595	DNA-templated transcription, initiation
GKO49_RS09270	COG2244	polysaccharide biosynthetic process
GKO49_RS09300	COG2226	methyltransferase
GKO49_RS09310	COG0438	transferase activity, transferring glycosyl groups
GKO49_RS09325	COG1136	(ABC) transporter
GKO49_RS09340	COG0477	Major facilitator Superfamily
GKO49_RS09350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKO49_RS09365	COG1253	flavin adenine dinucleotide binding
GKO49_RS09375	COG0306	phosphate transporter
GKO49_RS09405	COG0504	CTP synthase activity
GKO49_RS09410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GKO49_RS09420	COG0148	phosphopyruvate hydratase activity
GKO49_RS09425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GKO49_RS09430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GKO49_RS09440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GKO49_RS09450	COG2840	Smr protein MutS2
GKO49_RS09455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GKO49_RS09460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GKO49_RS09465	COG1238	metal cluster binding
GKO49_RS09480	COG1534	Rna-binding protein
GKO49_RS09485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GKO49_RS09495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GKO49_RS09500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKO49_RS09510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GKO49_RS09515	COG1546	Belongs to the CinA family
GKO49_RS09530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GKO49_RS09535	COG2137	regulation of response to DNA damage stimulus
GKO49_RS09540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GKO49_RS09545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GKO49_RS09565	COG0305	Participates in initiation and elongation during chromosome replication
GKO49_RS09570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKO49_RS09595	COG1741	Belongs to the pirin family
GKO49_RS09600	COG0583	DNA-binding transcription factor activity
GKO49_RS09630	COG0351	phosphomethylpyrimidine kinase
GKO49_RS09640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GKO49_RS09645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GKO49_RS09660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKO49_RS09670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GKO49_RS09675	COG3734	2-keto-3-deoxy-galactonokinase
GKO49_RS09685	COG4948	Mandelate Racemase Muconate Lactonizing
GKO49_RS09690	COG0800	Aldolase
GKO49_RS09725	COG3039	Transposase
GKO49_RS09735	COG3039	Transposase
GKO49_RS09825	COG2205	protein histidine kinase activity
GKO49_RS09855	COG2205	protein histidine kinase activity
GKO49_RS09870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GKO49_RS09920	COG1136	(ABC) transporter
GKO49_RS09960	COG0302	gtp cyclohydrolase
GKO49_RS09965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKO49_RS10020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKO49_RS10025	COG0302	gtp cyclohydrolase
GKO49_RS10055	COG0477	Major facilitator Superfamily
GKO49_RS10065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_RS10180	COG1929	Belongs to the glycerate kinase type-1 family
GKO49_RS10185	COG2271	Major facilitator Superfamily
GKO49_RS10200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GKO49_RS10205	COG0861	Integral membrane protein TerC family
GKO49_RS10215	COG0584	glycerophosphoryl diester phosphodiesterase
GKO49_RS10225	COG0671	phosphoesterase, PA-phosphatase related
GKO49_RS10235	COG0726	polysaccharide deacetylase
GKO49_RS10240	COG0706	membrane insertase activity
GKO49_RS10255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GKO49_RS10270	COG0187	DNA topoisomerase II activity
GKO49_RS10280	COG0501	Belongs to the peptidase M48B family
GKO49_RS10310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GKO49_RS10320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_RS10330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GKO49_RS10340	COG4772	TonB-dependent receptor
GKO49_RS10355	COG3039	Transposase
GKO49_RS10360	COG1304	FMN binding
GKO49_RS10380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GKO49_RS10390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKO49_RS10480	COG2826	transposase and inactivated derivatives, IS30 family
GKO49_RS10505	COG3039	Transposase
GKO49_RS10515	COG1090	epimerase
GKO49_RS10525	COG0642	Histidine kinase
GKO49_RS10535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKO49_RS10640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GKO49_RS10715	COG3264	Mechanosensitive ion channel
GKO49_RS10715	COG1511	domain protein
GKO49_RS10730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GKO49_RS10735	COG2354	Protein conserved in bacteria
GKO49_RS10740	COG1649	PFAM Uncharacterised BCR, COG1649
GKO49_RS10760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GKO49_RS10785	COG0702	epimerase
GKO49_RS10800	COG1858	cytochrome C peroxidase
GKO49_RS10805	COG0366	Alpha amylase catalytic
GKO49_RS10810	COG0366	Alpha amylase catalytic
GKO49_RS10840	COG1609	Transcriptional regulator
GKO49_RS10870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKO49_RS10875	COG1217	gtp-binding protein TYPA
GKO49_RS10970	COG1047	Peptidyl-prolyl cis-trans
GKO49_RS10995	COG3781	membrane
GKO49_RS11005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKO49_RS11035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKO49_RS11045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKO49_RS11055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GKO49_RS11080	COG3710	Transcriptional regulator
GKO49_RS11085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GKO49_RS11095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GKO49_RS11130	COG0066	3-isopropylmalate dehydratase activity
GKO49_RS11135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GKO49_RS11165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GKO49_RS11170	COG1538	Outer membrane efflux protein
GKO49_RS11175	COG1519	Transferase
GKO49_RS11180	COG1560	Kdo2-lipid A biosynthetic process
GKO49_RS11225	COG0308	aminopeptidase N
GKO49_RS11230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GKO49_RS11240	COG0330	HflC and HflK could
GKO49_RS11245	COG0330	HflC and HflK could
GKO49_RS11265	COG0678	peroxiredoxin activity
GKO49_RS11275	COG2826	transposase and inactivated derivatives, IS30 family
GKO49_RS11300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GKO49_RS11305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKO49_RS11310	COG0583	DNA-binding transcription factor activity
GKO49_RS11315	COG3634	alkyl hydroperoxide reductase activity
GKO49_RS11325	COG2890	protein-(glutamine-N5) methyltransferase activity
GKO49_RS11365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKO49_RS11365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKO49_RS11380	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GKO49_RS11405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GKO49_RS11430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKO49_RS11445	COG1404	Belongs to the peptidase S8 family
GKO49_RS11450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GKO49_RS11480	COG1295	ribonuclease BN
GKO49_RS11485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKO49_RS11505	COG0521	Mo-molybdopterin cofactor biosynthetic process
GKO49_RS11515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GKO49_RS11520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GKO49_RS11530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GKO49_RS11545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKO49_RS11555	COG0193	aminoacyl-tRNA hydrolase activity
GKO49_RS11560	COG0012	GTP binding
GKO49_RS11590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GKO49_RS11595	COG0250	Participates in transcription elongation, termination and antitermination
GKO49_RS11600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GKO49_RS11610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GKO49_RS11615	COG0222	ribosome binding
GKO49_RS11620	COG0085	RNA polymerase activity
GKO49_RS11625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GKO49_RS11630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GKO49_RS11635	COG0049	tRNA binding
GKO49_RS11655	COG0051	transcription antitermination factor activity, RNA binding
GKO49_RS11660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GKO49_RS11665	COG0088	Forms part of the polypeptide exit tunnel
GKO49_RS11670	COG0089	rRNA binding
GKO49_RS11685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GKO49_RS11695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GKO49_RS11700	COG0255	Belongs to the universal ribosomal protein uL29 family
GKO49_RS11705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GKO49_RS11710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GKO49_RS11720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GKO49_RS11750	COG1841	ribosomal large subunit assembly
GKO49_RS11760	COG0201	protein transport
GKO49_RS11770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GKO49_RS11775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GKO49_RS11785	COG0203	ribosomal protein L17
GKO49_RS11820	COG2234	aminopeptidase activity
GKO49_RS11830	COG4942	peptidase
GKO49_RS11835	COG0793	Belongs to the peptidase S41A family
GKO49_RS11885	COG0386	Belongs to the glutathione peroxidase family
GKO49_RS11895	COG1322	Protein conserved in bacteria
GKO49_RS11905	COG0531	amino acid
GKO49_RS11920	COG0210	DNA helicase
GKO49_RS11935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_RS11940	COG0583	DNA-binding transcription factor activity
GKO49_RS11945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKO49_RS11955	COG2159	amidohydrolase
GKO49_RS11980	COG0357	Ribosomal RNA small subunit methyltransferase G
GKO49_RS11985	COG3540	Alkaline phosphatase
GKO49_RS11995	COG2091	lysine biosynthetic process via aminoadipic acid
GKO49_RS12010	COG0708	Exodeoxyribonuclease III
GKO49_RS12025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GKO49_RS12030	COG3162	membrane
GKO49_RS12070	COG3507	Belongs to the glycosyl hydrolase 43 family
GKO49_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS12095	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKO49_RS12100	COG4948	Mandelate Racemase Muconate Lactonizing
GKO49_RS12105	COG4807	Protein conserved in bacteria
GKO49_RS12110	COG1643	Atp-dependent helicase
GKO49_RS12120	COG1187	pseudouridine synthase activity
GKO49_RS12130	COG0667	Aldo Keto reductase
GKO49_RS12135	COG2130	NADP-dependent
GKO49_RS12140	COG0656	L-ascorbic acid biosynthetic process
GKO49_RS12170	COG2755	lipolytic protein G-D-S-L family
GKO49_RS12185	COG3186	Phenylalanine-4-hydroxylase
GKO49_RS12190	COG1522	sequence-specific DNA binding
GKO49_RS12240	COG1064	alcohol dehydrogenase
GKO49_RS12245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_RS12255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_RS12265	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_RS12285	COG0676	glucose-6-phosphate 1-epimerase activity
GKO49_RS12335	COG0800	Aldolase
GKO49_RS12340	COG0129	dihydroxy-acid dehydratase activity
GKO49_RS12345	COG0363	glucosamine-6-phosphate deaminase activity
GKO49_RS12355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKO49_RS12370	COG0354	folic acid binding
GKO49_RS12385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GKO49_RS12400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GKO49_RS12415	COG4591	ABC-type transport system involved in lipoprotein release permease component
GKO49_RS12440	COG0811	peptide transport
GKO49_RS12455	COG1663	tetraacyldisaccharide 4'-kinase activity
GKO49_RS12465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKO49_RS12475	COG0322	excinuclease ABC activity
GKO49_RS12535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GKO49_RS12575	COG2211	Major facilitator Superfamily
GKO49_RS12595	COG3693	PFAM glycoside hydrolase, family 10
GKO49_RS12620	COG0246	Mannitol dehydrogenase
GKO49_RS12625	COG1472	Belongs to the glycosyl hydrolase 3 family
GKO49_RS12635	COG4948	Mandelate Racemase Muconate Lactonizing
GKO49_RS12645	COG3661	Belongs to the glycosyl hydrolase 67 family
GKO49_RS12660	COG0037	tRNA processing
GKO49_RS12665	COG2974	May be involved in recombination
GKO49_RS12690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GKO49_RS12700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKO49_RS12710	COG0805	protein transport
GKO49_RS12720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GKO49_RS12720	COG0519	Catalyzes the synthesis of GMP from XMP
GKO49_RS12735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GKO49_RS12740	COG0752	glycyl-tRNA synthetase alpha subunit
GKO49_RS12750	COG0457	Tetratricopeptide repeat
GKO49_RS12755	COG4771	TonB-dependent receptor
GKO49_RS12770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GKO49_RS12795	COG0523	cobalamin synthesis protein
GKO49_RS12850	COG1960	acyl-CoA dehydrogenase activity
GKO49_RS12855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKO49_RS12860	COG4770	biotin carboxylase activity
GKO49_RS12905	COG2072	flavoprotein involved in K transport
GKO49_RS12925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GKO49_RS12970	COG0084	hydrolase, TatD family'
GKO49_RS12985	COG0583	DNA-binding transcription factor activity
GKO49_RS12990	COG2814	Major facilitator Superfamily
GKO49_RS13000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GKO49_RS13005	COG1902	pentaerythritol trinitrate reductase activity
GKO49_RS13035	COG0745	RESPONSE REGULATOR receiver
GKO49_RS13055	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GKO49_RS13060	COG0583	DNA-binding transcription factor activity
GKO49_RS13090	COG0702	epimerase
GKO49_RS13095	COG1733	regulation of RNA biosynthetic process
GKO49_RS13145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKO49_RS13160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GKO49_RS13195	COG2911	Protein conserved in bacteria
GKO49_RS13200	COG0729	surface antigen
GKO49_RS13215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GKO49_RS13220	COG3118	belongs to the thioredoxin family
GKO49_RS13230	COG2884	Cell division ATP-binding protein ftsE
GKO49_RS13235	COG2177	Part of the ABC transporter FtsEX involved in
GKO49_RS13240	COG3437	response regulator, receiver
GKO49_RS13245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GKO49_RS13250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKO49_RS13260	COG1252	NADH dehydrogenase
GKO49_RS13285	COG0459	protein refolding
GKO49_RS13295	COG4771	TonB-dependent receptor
GKO49_RS13310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GKO49_RS13355	COG3386	PFAM SMP-30 Gluconolaconase
GKO49_RS13370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GKO49_RS13405	COG2353	YceI-like domain
GKO49_RS13475	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GKO49_RS13480	COG3023	N-Acetylmuramoyl-L-alanine amidase
GKO49_RS13490	COG4948	Mandelate Racemase Muconate Lactonizing
GKO49_RS13515	COG0531	amino acid
GKO49_RS13540	COG4682	membrane
GKO49_RS13545	COG2133	pyrroloquinoline quinone binding
GKO49_RS13600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GKO49_RS13605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GKO49_RS13615	COG1610	YqeY-like protein
GKO49_RS13630	COG1295	ribonuclease BN
GKO49_RS13635	COG0358	DNA primase activity
GKO49_RS13645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKO49_RS13650	COG0308	aminopeptidase N
GKO49_RS13695	COG0772	Belongs to the SEDS family
GKO49_RS13710	COG1792	Involved in formation and maintenance of cell shape
GKO49_RS13715	COG1077	Cell shape determining protein MreB Mrl
GKO49_RS13720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKO49_RS13765	COG2199	diguanylate cyclase activity
GKO49_RS13770	COG0308	aminopeptidase N
GKO49_RS13800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GKO49_RS13830	COG0436	Aminotransferase
GKO49_RS13845	COG1505	serine-type exopeptidase activity
GKO49_RS13870	COG0181	hydroxymethylbilane synthase activity
GKO49_RS13880	COG3275	phosphorelay sensor kinase activity
GKO49_RS13925	COG0659	secondary active sulfate transmembrane transporter activity
GKO49_RS13930	COG5297	Belongs to the glycosyl hydrolase family 6
GKO49_RS13930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_RS13935	COG0840	transmembrane signaling receptor activity
GKO49_RS13990	COG3039	Transposase
GKO49_RS14010	COG0598	Magnesium transport protein CorA
GKO49_RS14020	COG1113	amino acid transport
GKO49_RS14025	COG5297	Belongs to the glycosyl hydrolase family 6
GKO49_RS14030	COG4305	rare lipoprotein A
GKO49_RS14035	COG0697	spore germination
GKO49_RS14090	COG4221	oxidoreductase activity
GKO49_RS14120	COG0456	acetyltransferase
GKO49_RS14130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GKO49_RS14175	COG2111	Na H antiporter
GKO49_RS14175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GKO49_RS14180	COG1006	Multisubunit Na H antiporter MnhC subunit
GKO49_RS14185	COG0651	ATP synthesis coupled electron transport
GKO49_RS14195	COG2212	antiporter activity
GKO49_RS14200	COG1320	monovalent cation:proton antiporter activity
GKO49_RS14210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GKO49_RS14230	COG3104	oligopeptide transport
GKO49_RS14235	COG3483	tryptophan 2,3-dioxygenase activity
GKO49_RS14245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GKO49_RS14280	COG0183	Belongs to the thiolase family
GKO49_RS14330	COG2197	response regulator
GKO49_RS14390	COG0742	ribosomal rna small subunit methyltransferase
GKO49_RS14395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GKO49_RS14405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GKO49_RS14410	COG0405	Gamma-glutamyltransferase
GKO49_RS14470	COG1166	arginine decarboxylase activity
GKO49_RS14475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GKO49_RS14520	COG0606	chelatase, subunit chli
GKO49_RS14550	COG0726	polysaccharide deacetylase
GKO49_RS14550	COG1649	PFAM Uncharacterised BCR, COG1649
GKO49_RS14555	COG1215	transferase activity, transferring glycosyl groups
GKO49_RS14565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GKO49_RS14570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GKO49_RS14575	COG1609	Transcriptional regulator
GKO49_RS14585	COG2188	Transcriptional regulator
GKO49_RS14600	COG3250	beta-galactosidase activity
GKO49_RS14650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GKO49_RS14655	COG4191	Histidine kinase
GKO49_RS14660	COG0784	Response regulator, receiver
GKO49_RS14665	COG4251	negative regulation of phosphorylation
GKO49_RS14670	COG2823	Periplasmic or secreted lipoprotein
GKO49_RS14675	COG0673	inositol 2-dehydrogenase activity
GKO49_RS14680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GKO49_RS14715	COG1056	cytidyltransferase-related domain
GKO49_RS14715	COG1051	belongs to the nudix hydrolase family
GKO49_RS14740	COG2921	Belongs to the UPF0250 family
GKO49_RS14750	COG1686	Belongs to the peptidase S11 family
GKO49_RS14755	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GKO49_RS14760	COG2951	lytic endotransglycosylase activity
GKO49_RS14845	COG3829	transcription factor binding
GKO49_RS14855	COG3039	Transposase
GKO49_RS14885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GKO49_RS14890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GKO49_RS14900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKO49_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS14930	COG1399	metal-binding, possibly nucleic acid-binding protein
GKO49_RS14975	COG1518	maintenance of DNA repeat elements
GKO49_RS14980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GKO49_RS15020	COG2188	Transcriptional regulator
GKO49_RS15035	COG1450	Type ii and iii secretion system protein
GKO49_RS15050	COG3166	PFAM Fimbrial assembly family protein
GKO49_RS15055	COG3156	type II secretion system protein K
GKO49_RS15060	COG4795	General secretion pathway protein
GKO49_RS15065	COG2165	general secretion pathway protein
GKO49_RS15070	COG4970	Tfp pilus assembly protein FimT
GKO49_RS15075	COG2165	general secretion pathway protein
GKO49_RS15080	COG1459	type II secretion system
GKO49_RS15090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GKO49_RS15100	COG5295	Hep Hag repeat protein
GKO49_RS15105	COG0047	phosphoribosylformylglycinamidine synthase activity
GKO49_RS15105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKO49_RS15110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GKO49_RS15115	COG4974	Belongs to the 'phage' integrase family
GKO49_RS15130	COG0795	lipopolysaccharide-transporting ATPase activity
GKO49_RS15140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKO49_RS15155	COG0525	valine-tRNA ligase activity
GKO49_RS15185	COG3039	Transposase
GKO49_RS15335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKO49_RS15355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GKO49_RS15360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GKO49_RS15360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GKO49_RS15365	COG0802	atpase or kinase
GKO49_RS15370	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKO49_RS15375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GKO49_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS15405	COG0501	Belongs to the peptidase M48B family
GKO49_RS15415	COG2081	HI0933 family
GKO49_RS15420	COG4681	YaeQ
GKO49_RS15425	COG1671	Belongs to the UPF0178 family
GKO49_RS15435	COG0625	glutathione transferase activity
GKO49_RS15445	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GKO49_RS15455	COG0513	Belongs to the DEAD box helicase family
GKO49_RS15460	COG0488	(ABC) transporter
GKO49_RS15480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GKO49_RS15485	COG0483	inositol monophosphate 1-phosphatase activity
GKO49_RS15500	COG3300	MHYT domain
GKO49_RS15500	COG5001	Diguanylate cyclase
GKO49_RS15505	COG1509	lysine 2,3-aminomutase activity
GKO49_RS15520	COG0402	S-adenosylhomocysteine deaminase activity
GKO49_RS15525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKO49_RS15550	COG0646	methionine synthase
GKO49_RS15550	COG1410	methionine synthase
GKO49_RS15555	COG0646	methionine synthase
GKO49_RS15555	COG1410	methionine synthase
GKO49_RS15560	COG2226	methyltransferase
GKO49_RS15565	COG1960	acyl-CoA dehydrogenase activity
GKO49_RS15590	COG0557	exoribonuclease II activity
GKO49_RS15605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKO49_RS15620	COG1555	photosystem II stabilization
GKO49_RS15625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKO49_RS15680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GKO49_RS15685	COG3177	Filamentation induced by cAMP protein fic
GKO49_RS15690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKO49_RS15705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GKO49_RS15730	COG4191	Histidine kinase
GKO49_RS15735	COG0028	Belongs to the TPP enzyme family
GKO49_RS15750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GKO49_RS15755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKO49_RS15785	COG5383	Protein conserved in bacteria
GKO49_RS15800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKO49_RS15805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_RS15810	COG1473	amidohydrolase
GKO49_RS15820	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GKO49_RS15820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GKO49_RS15825	COG3328	transposase activity
GKO49_RS15915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GKO49_RS15930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKO49_RS15935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GKO49_RS15945	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GKO49_RS15950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GKO49_RS15955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GKO49_RS16005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKO49_RS16020	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GKO49_RS16100	COG1047	Peptidyl-prolyl cis-trans
GKO49_RS16105	COG0791	NLP P60 protein
GKO49_RS16110	COG0791	NLP P60 protein
GKO49_RS16125	COG1301	dicarboxylic acid transport
GKO49_RS16130	COG1785	Belongs to the alkaline phosphatase family
GKO49_RS16135	COG0037	tRNA processing
GKO49_RS16140	COG1722	exodeoxyribonuclease VII activity
GKO49_RS16145	COG0142	geranyltranstransferase activity
GKO49_RS16165	COG0312	modulator of DNA gyrase
GKO49_RS16170	COG3028	Belongs to the UPF0307 family
GKO49_RS16175	COG0312	modulator of DNA gyrase
GKO49_RS16185	COG3164	Protein of unknown function
GKO49_RS16200	COG2968	Membrane
GKO49_RS16205	COG3039	Transposase
GKO49_RS16235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GKO49_RS16260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GKO49_RS16285	COG3118	belongs to the thioredoxin family
GKO49_RS16315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKO49_RS16330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKO49_RS16335	COG1393	Belongs to the ArsC family
GKO49_RS16340	COG0431	NADPH-dependent FMN reductase
GKO49_RS16345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GKO49_RS16350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKO49_RS16370	COG5002	protein histidine kinase activity
GKO49_RS16370	COG2205	protein histidine kinase activity
GKO49_RS16370	COG0784	Response regulator, receiver
GKO49_RS16415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKO49_RS16435	COG0842	Transport permease protein
GKO49_RS16440	COG1131	(ABC) transporter
GKO49_RS16470	COG1476	TRANSCRIPTIONal
GKO49_RS16480	COG4555	ABC transporter
GKO49_RS16515	COG0625	glutathione transferase activity
GKO49_RS16560	COG0583	DNA-binding transcription factor activity
GKO49_RS16600	COG1199	ATP-dependent helicase activity
GKO49_RS16615	COG1566	PFAM secretion protein HlyD family protein
GKO49_RS16635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GKO49_RS16675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GKO49_RS16675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GKO49_RS16680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GKO49_RS16695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GKO49_RS16730	COG3237	CsbD-like
GKO49_RS16735	COG0180	Tryptophanyl-tRNA synthetase
GKO49_RS16740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKO49_RS16790	COG0753	catalase activity
GKO49_RS16795	COG1595	DNA-templated transcription, initiation
GKO49_RS16805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKO49_RS16815	COG0628	permease
GKO49_RS16825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GKO49_RS16830	COG1040	competence protein
GKO49_RS16835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GKO49_RS16840	COG0156	8-amino-7-oxononanoate synthase activity
GKO49_RS16850	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS16865	COG0463	Glycosyl transferase, family 2
GKO49_RS16875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GKO49_RS16880	COG3100	YcgL domain-containing protein
GKO49_RS16900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKO49_RS16915	COG2239	Acts as a magnesium transporter
GKO49_RS16925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKO49_RS16925	COG0045	succinate-CoA ligase (ADP-forming) activity
GKO49_RS16925	COG1042	CoA-binding domain protein
GKO49_RS16935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKO49_RS16940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKO49_RS16980	COG3485	protocatechuate 3,4-dioxygenase
GKO49_RS16985	COG3485	protocatechuate 3,4-dioxygenase
GKO49_RS17000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKO49_RS17005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GKO49_RS17030	COG4221	oxidoreductase activity
GKO49_RS17045	COG0018	arginyl-trna synthetase
GKO49_RS17050	COG2003	Belongs to the UPF0758 family
GKO49_RS17055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GKO49_RS17080	COG0463	Glycosyl transferase, family 2
GKO49_RS17095	COG1475	DNA binding
GKO49_RS17100	COG1192	Involved in chromosome partitioning
GKO49_RS17115	COG0708	Exodeoxyribonuclease III
GKO49_RS17120	COG2211	Major facilitator Superfamily
GKO49_RS17135	COG0739	heme binding
GKO49_RS17180	COG0745	RESPONSE REGULATOR receiver
GKO49_RS17220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GKO49_RS17235	COG2814	Major facilitator Superfamily
GKO49_RS17250	COG1289	transmembrane transporter activity
GKO49_RS17265	COG0577	efflux transmembrane transporter activity
GKO49_RS17265	COG1136	(ABC) transporter
GKO49_RS17270	COG0151	Belongs to the GarS family
GKO49_RS17280	COG0419	ATPase involved in DNA repair
GKO49_RS17295	COG2267	carboxylic ester hydrolase activity
GKO49_RS17300	COG2267	carboxylic ester hydrolase activity
GKO49_RS17305	COG2267	carboxylic ester hydrolase activity
GKO49_RS17325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GKO49_RS17370	COG0439	Biotin carboxylase
GKO49_RS17380	COG0511	ligase activity, forming carbon-carbon bonds
GKO49_RS17385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GKO49_RS17395	COG1324	tolerance protein
GKO49_RS17430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GKO49_RS17450	COG0534	Mate efflux family protein
GKO49_RS17455	COG0616	signal peptide processing
GKO49_RS17465	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS17480	COG0009	L-threonylcarbamoyladenylate synthase
GKO49_RS17485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKO49_RS17485	COG1754	DNA topoisomerase type I activity
GKO49_RS17500	COG2922	Belongs to the Smg family
GKO49_RS17505	COG0758	DNA mediated transformation
GKO49_RS17510	COG1652	LysM domain
GKO49_RS17515	COG0242	peptide deformylase activity
GKO49_RS17520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GKO49_RS17525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKO49_RS17525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GKO49_RS17575	COG1560	Kdo2-lipid A biosynthetic process
GKO49_RS17585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKO49_RS17700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKO49_RS17705	COG0735	belongs to the Fur family
GKO49_RS17765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GKO49_RS17770	COG0084	hydrolase, TatD family'
GKO49_RS17785	COG1960	acyl-CoA dehydrogenase activity
GKO49_RS17800	COG0367	asparagine synthase
GKO49_RS17810	COG0305	Participates in initiation and elongation during chromosome replication
GKO49_RS17815	COG0415	Belongs to the DNA photolyase family
GKO49_RS17830	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_RS17930	COG5001	Diguanylate cyclase
GKO49_RS17930	COG5002	protein histidine kinase activity
GKO49_RS17935	COG1187	pseudouridine synthase activity
GKO49_RS17955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKO49_RS17965	COG0475	glutathione-regulated potassium exporter activity
GKO49_RS17970	COG5002	protein histidine kinase activity
GKO49_RS17970	COG5000	phosphorelay sensor kinase activity
GKO49_RS18020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GKO49_RS18060	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GKO49_RS18070	COG0531	amino acid
GKO49_RS18075	COG0531	amino acid
GKO49_RS18085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKO49_RS18090	COG0277	FAD linked oxidase domain protein
GKO49_RS18140	COG0583	DNA-binding transcription factor activity
GKO49_RS18150	COG3039	Transposase
GKO49_RS18175	COG1451	nucleotide metabolic process
GKO49_RS18195	COG0183	Belongs to the thiolase family
GKO49_RS18225	COG1793	dna ligase
GKO49_RS18225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GKO49_RS18235	COG1793	dna ligase
GKO49_RS18240	COG1201	RNA secondary structure unwinding
GKO49_RS18260	COG1278	Cold shock
GKO49_RS18265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GKO49_RS18270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GKO49_RS18280	COG3046	protein related to deoxyribodipyrimidine photolyase
GKO49_RS18285	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GKO49_RS18290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GKO49_RS18305	COG2954	triphosphatase activity
GKO49_RS18320	COG1381	Involved in DNA repair and RecF pathway recombination
GKO49_RS18350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKO49_RS18365	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKO49_RS18365	COG1024	Enoyl-CoA hydratase
GKO49_RS18385	COG1024	Enoyl-CoA hydratase
GKO49_RS18390	COG1960	acyl-CoA dehydrogenase activity
GKO49_RS18460	COG2353	YceI-like domain
GKO49_RS18470	COG2353	YceI-like domain
GKO49_RS18485	COG1760	l-serine dehydratase
GKO49_RS18495	COG0626	cystathionine gamma-synthase activity
GKO49_RS18500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKO49_RS18505	COG0739	heme binding
GKO49_RS18510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GKO49_RS18515	COG1272	protein, Hemolysin III
GKO49_RS18535	COG0463	Glycosyl transferase, family 2
GKO49_RS18545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GKO49_RS18555	COG4771	TonB-dependent receptor
GKO49_RS18560	COG1309	transcriptional regulator
GKO49_RS18570	COG1960	acyl-CoA dehydrogenase activity
GKO49_RS18600	COG0509	glycine decarboxylation via glycine cleavage system
GKO49_RS18615	COG0330	HflC and HflK could
GKO49_RS18630	COG3956	TIGRFAM MazG family protein
GKO49_RS18640	COG0494	nUDIX hydrolase
GKO49_RS18650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GKO49_RS18655	COG0837	glucose binding
GKO49_RS18670	COG3858	chitin binding
GKO49_RS18670	COG1388	LysM domain
GKO49_RS18690	COG1472	Belongs to the glycosyl hydrolase 3 family
GKO49_RS18745	COG3537	Alpha-1,2-mannosidase
GKO49_RS18795	COG1446	asparaginase
GKO49_RS18835	COG0631	protein serine/threonine phosphatase activity
GKO49_RS18845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GKO49_RS18870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GKO49_RS18910	COG0544	peptidyl-prolyl cis-trans isomerase activity
GKO49_RS18985	COG4783	chaperone-mediated protein folding
GKO49_RS19010	COG0438	transferase activity, transferring glycosyl groups
GKO49_RS19015	COG0671	phosphoesterase, PA-phosphatase related
GKO49_RS19020	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GKO49_RS19040	COG2833	Protein of unknown function (DUF455)
GKO49_RS19060	COG0285	dihydrofolate synthase activity
GKO49_RS19070	COG0588	phosphoglycerate mutase activity
GKO49_RS19100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GKO49_RS19105	COG4208	sulfate ABC transporter
GKO49_RS19110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GKO49_RS19115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GKO49_RS19120	COG0156	8-amino-7-oxononanoate synthase activity
GKO49_RS19145	COG0604	alcohol dehydrogenase
GKO49_RS19150	COG1902	pentaerythritol trinitrate reductase activity
GKO49_RS19150	COG0446	pyridine nucleotide-disulphide oxidoreductase
GKO49_RS19180	COG0584	glycerophosphoryl diester phosphodiesterase
GKO49_RS19230	COG1278	Cold shock
GKO49_RS19235	COG0412	Dienelactone hydrolase
GKO49_RS19255	COG0717	Belongs to the dCTP deaminase family
GKO49_RS19260	COG0489	protein tyrosine kinase activity
GKO49_RS19345	COG0489	protein tyrosine kinase activity
GKO49_RS19350	COG0717	Belongs to the dCTP deaminase family
GKO49_RS19370	COG0412	Dienelactone hydrolase
GKO49_RS19380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKO49_RS19430	COG2890	protein-(glutamine-N5) methyltransferase activity
GKO49_RS19435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GKO49_RS19440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GKO49_RS19445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GKO49_RS19465	COG0101	tRNA pseudouridine synthase activity
GKO49_RS19470	COG0135	phosphoribosylanthranilate isomerase activity
GKO49_RS19480	COG0133	tryptophan synthase activity
GKO49_RS19490	COG0159	tryptophan synthase activity
GKO49_RS19495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GKO49_RS19500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKO49_RS19550	COG0149	triose-phosphate isomerase activity
GKO49_RS19565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKO49_RS19575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKO49_RS19580	COG0649	NAD binding
GKO49_RS19585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GKO49_RS19590	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GKO49_RS19595	COG1034	ATP synthesis coupled electron transport
GKO49_RS19600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GKO49_RS19640	COG0779	Required for maturation of 30S ribosomal subunits
GKO49_RS19645	COG0195	Participates in both transcription termination and antitermination
GKO49_RS19665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GKO49_RS19670	COG1185	polyribonucleotide nucleotidyltransferase activity
GKO49_RS19705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GKO49_RS19715	COG2095	MarC family integral membrane protein
GKO49_RS19735	COG1611	Belongs to the LOG family
GKO49_RS19775	COG4969	Belongs to the N-Me-Phe pilin family
GKO49_RS19780	COG0556	nucleotide-excision repair
GKO49_RS19820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GKO49_RS19830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GKO49_RS19835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GKO49_RS19890	COG0438	transferase activity, transferring glycosyl groups
GKO49_RS19895	COG0438	transferase activity, transferring glycosyl groups
GKO49_RS19905	COG0438	transferase activity, transferring glycosyl groups
GKO49_RS19950	COG3040	lipid binding
GKO49_RS20010	COG0069	glutamate synthase activity
GKO49_RS20010	COG0070	glutamate synthase
GKO49_RS20010	COG0067	glutamate synthase
GKO49_RS20015	COG0493	'glutamate synthase
GKO49_RS20035	COG0840	transmembrane signaling receptor activity
GKO49_RS20045	COG0840	transmembrane signaling receptor activity
GKO49_RS20060	COG3039	Transposase
GKO49_RS20070	COG2205	protein histidine kinase activity
GKO49_RS20075	COG0745	RESPONSE REGULATOR receiver
GKO49_RS20130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKO49_RS20135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKO49_RS20180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GKO49_RS20255	COG4771	TonB-dependent receptor
GKO49_RS20265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GKO49_RS20285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GKO49_RS20290	COG1360	Flagellar Motor Protein
GKO49_RS20300	COG0835	chemotaxis
GKO49_RS20310	COG0745	RESPONSE REGULATOR receiver
GKO49_RS20330	COG0840	transmembrane signaling receptor activity
GKO49_RS20350	COG0840	transmembrane signaling receptor activity
GKO49_RS20360	COG0840	transmembrane signaling receptor activity
GKO49_RS20365	COG0840	transmembrane signaling receptor activity
GKO49_RS20370	COG0840	transmembrane signaling receptor activity
GKO49_RS20375	COG0840	transmembrane signaling receptor activity
GKO49_RS20390	COG0835	chemotaxis
GKO49_RS20445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKO49_RS20475	COG0318	PFAM AMP-dependent synthetase and ligase
GKO49_RS20480	COG1024	Enoyl-CoA hydratase
GKO49_RS20485	COG0784	Response regulator, receiver
GKO49_RS20485	COG2198	Histidine kinase
GKO49_RS20485	COG2205	protein histidine kinase activity
GKO49_RS20560	COG1127	ABC transporter
GKO49_RS20565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKO49_RS20570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GKO49_RS20585	COG2853	Lipoprotein
GKO49_RS20605	COG2895	sulfate adenylyltransferase (ATP) activity
GKO49_RS20605	COG0529	Catalyzes the synthesis of activated sulfate
GKO49_RS20620	COG3293	Transposase
GKO49_RS20625	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKO49_RS20660	COG2969	positive regulation of protein catabolic process
GKO49_RS20665	COG0625	glutathione transferase activity
GKO49_RS20670	COG2857	Cytochrome c1
GKO49_RS20675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GKO49_RS20680	COG0723	plastoquinol--plastocyanin reductase activity
GKO49_RS20685	COG0741	lytic transglycosylase activity
GKO49_RS20705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKO49_RS20710	COG1702	phosphate starvation-inducible protein PhoH
GKO49_RS20730	COG4535	Mg2 and Co2 transporter CorC
GKO49_RS20745	COG1012	belongs to the aldehyde dehydrogenase family
GKO49_RS20755	COG1177	transmembrane transport
GKO49_RS20765	COG3842	ATPase activity
GKO49_RS20800	COG0174	glutamine synthetase
GKO49_RS20815	COG0477	Major facilitator Superfamily
GKO49_RS20825	COG0243	molybdopterin cofactor binding
GKO49_RS20835	COG2223	nitrite transmembrane transporter activity
GKO49_RS20845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GKO49_RS20855	COG3039	Transposase
GKO49_RS20870	COG2733	membrane
GKO49_RS20875	COG0784	Response regulator, receiver
GKO49_RS20875	COG2205	protein histidine kinase activity
GKO49_RS20875	COG5002	protein histidine kinase activity
GKO49_RS20885	COG3039	Transposase
GKO49_RS20890	COG2902	Dehydrogenase
GKO49_RS20900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_RS20905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKO49_RS20925	COG1609	Transcriptional regulator
GKO49_RS20930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKO49_RS20930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKO49_RS20935	COG1105	Belongs to the carbohydrate kinase PfkB family
GKO49_RS20940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKO49_RS20940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKO49_RS20955	COG3039	Transposase
GKO49_RS20975	COG3039	Transposase
GKO49_RS21060	COG0632	four-way junction helicase activity
GKO49_RS21070	COG2255	four-way junction helicase activity
GKO49_RS21075	COG0824	Thioesterase
GKO49_RS21085	COG0848	biopolymer transport protein
GKO49_RS21100	COG2885	chlorophyll binding
GKO49_RS21110	COG0602	queuosine metabolic process
GKO49_RS21135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GKO49_RS21160	COG0514	ATP-dependent DNA helicase (RecQ)
GKO49_RS21165	COG0783	Belongs to the Dps family
GKO49_RS21170	COG1643	Atp-dependent helicase
GKO49_RS21205	COG0535	radical SAM domain protein
GKO49_RS21210	COG0535	radical SAM domain protein
GKO49_RS21215	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GKO49_RS21230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKO49_RS21240	COG1215	transferase activity, transferring glycosyl groups
GKO49_RS21245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKO49_RS21255	COG1199	ATP-dependent helicase activity
GKO49_RS21265	COG1397	ADP-ribosylglycohydrolase
GKO49_RS21275	COG0189	ligase activity
GKO49_RS21295	COG0840	transmembrane signaling receptor activity
GKO49_RS21300	COG0784	Response regulator, receiver
GKO49_RS21300	COG0643	Histidine kinase
GKO49_RS21300	COG2198	Histidine kinase
GKO49_RS21345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GKO49_RS21355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKO49_RS21360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GKO49_RS21370	COG0505	Belongs to the CarA family
GKO49_RS21375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GKO49_RS21385	COG2258	MOSC domain
GKO49_RS21390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKO49_RS21440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GKO49_RS21460	COG0477	Major facilitator Superfamily
GKO49_RS21470	COG1070	Carbohydrate kinase
GKO49_RS21485	COG3209	COG3209 Rhs family protein
GKO49_RS21525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_RS21530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GKO49_RS21580	COG0339	signal peptide processing
GKO49_RS21620	COG1956	GAF domain-containing protein
GKO49_RS21625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GKO49_RS21635	COG0720	synthase
GKO49_RS21640	COG0513	Belongs to the DEAD box helicase family
GKO49_RS21655	COG0625	glutathione transferase activity
GKO49_RS21685	COG0626	cystathionine gamma-synthase activity
GKO49_RS21730	COG3328	transposase activity
GKO49_RS21755	COG2086	electron transfer activity
GKO49_RS21780	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GKO49_RS21780	COG0662	Cupin 2, conserved barrel domain protein
GKO49_RS21785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKO49_RS21820	COG3218	ABC-type transport auxiliary lipoprotein component
GKO49_RS21820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GKO49_RS21825	COG1127	ABC transporter
GKO49_RS21830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKO49_RS21845	COG0442	prolyl-tRNA aminoacylation
GKO49_RS21855	COG1183	phosphatidylcholine synthase activity
GKO49_RS21885	COG3039	Transposase
GKO49_RS21905	COG1136	(ABC) transporter
GKO49_RS21950	COG0596	Alpha beta hydrolase
GKO49_RS21955	COG0727	PFAM Uncharacterised protein family (UPF0153)
GKO49_RS21960	COG0318	PFAM AMP-dependent synthetase and ligase
GKO49_RS21965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKO49_RS21995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GKO49_RS22005	COG0129	dihydroxy-acid dehydratase activity
GKO49_RS22170	COG0732	type I restriction modification DNA specificity domain
GKO49_RS22185	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GKO49_RS22230	COG0732	type I restriction modification DNA specificity domain
GKO49_RS22305	COG0587	DNA-directed DNA polymerase activity
GKO49_RS22320	COG1297	OPT oligopeptide transporter protein
GKO49_RS22345	COG1506	peptidase
GKO49_RS22345	COG0823	Involved in the tonB-independent uptake of proteins
GKO49_RS22365	COG2207	Transcriptional regulator
GKO49_RS22365	COG1917	Cupin 2, conserved barrel domain protein
GKO49_RS22390	COG0753	catalase activity
GKO49_RS22420	COG0126	phosphoglycerate kinase activity
GKO49_RS22430	COG0469	pyruvate kinase activity
GKO49_RS22435	COG3588	fructose-bisphosphate aldolase
GKO49_RS22440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GKO49_RS22485	COG0784	Response regulator, receiver
GKO49_RS22485	COG2198	Histidine kinase
GKO49_RS22485	COG2205	protein histidine kinase activity
GKO49_RS22505	COG0175	sulfate reduction
GKO49_RS22510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKO49_RS22515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GKO49_RS22520	COG0175	sulfate reduction
GKO49_RS22525	COG0529	Catalyzes the synthesis of activated sulfate
GKO49_RS22525	COG2895	sulfate adenylyltransferase (ATP) activity