locus-tag	class	description
IXO1088_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO1088_RS00020	COG0187	DNA topoisomerase II activity
IXO1088_RS00030	COG0501	Belongs to the peptidase M48B family
IXO1088_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO1088_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO1088_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO1088_RS00095	COG4772	TonB-dependent receptor
IXO1088_RS00110	COG3039	Transposase
IXO1088_RS00115	COG1304	FMN binding
IXO1088_RS00135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO1088_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO1088_RS00240	COG2826	transposase and inactivated derivatives, IS30 family
IXO1088_RS00265	COG3039	Transposase
IXO1088_RS00275	COG1090	epimerase
IXO1088_RS00285	COG0642	Histidine kinase
IXO1088_RS00295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO1088_RS00405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO1088_RS00480	COG3264	Mechanosensitive ion channel
IXO1088_RS00480	COG1511	domain protein
IXO1088_RS00495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO1088_RS00500	COG2354	Protein conserved in bacteria
IXO1088_RS00515	COG0297	glycogen (starch) synthase activity
IXO1088_RS00525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO1088_RS00550	COG0702	epimerase
IXO1088_RS00565	COG1858	cytochrome C peroxidase
IXO1088_RS00630	COG0513	Belongs to the DEAD box helicase family
IXO1088_RS00640	COG3039	Transposase
IXO1088_RS00680	COG1272	protein, Hemolysin III
IXO1088_RS00685	COG1111	helicase
IXO1088_RS00685	COG1205	dead DEAH box helicase
IXO1088_RS00745	COG0067	glutamate synthase
IXO1088_RS00745	COG0069	glutamate synthase activity
IXO1088_RS00745	COG0070	glutamate synthase
IXO1088_RS00750	COG0493	'glutamate synthase
IXO1088_RS00790	COG1609	Transcriptional regulator
IXO1088_RS00820	COG0366	Alpha amylase catalytic
IXO1088_RS00825	COG0366	Alpha amylase catalytic
IXO1088_RS00850	COG3039	Transposase
IXO1088_RS00880	COG0606	chelatase, subunit chli
IXO1088_RS00925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO1088_RS00930	COG1166	arginine decarboxylase activity
IXO1088_RS00940	COG3501	Rhs element vgr protein
IXO1088_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS01025	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO1088_RS01040	COG0210	DNA helicase
IXO1088_RS01055	COG3132	Protein of unknown function, DUF480
IXO1088_RS01060	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO1088_RS01065	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO1088_RS01140	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO1088_RS01150	COG1119	ATPase activity
IXO1088_RS01165	COG1125	glycine betaine transport
IXO1088_RS01165	COG0517	IMP dehydrogenase activity
IXO1088_RS01180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO1088_RS01185	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO1088_RS01190	COG3550	peptidyl-serine autophosphorylation
IXO1088_RS01195	COG1396	sequence-specific DNA binding
IXO1088_RS01220	COG0489	protein tyrosine kinase activity
IXO1088_RS01225	COG2062	phosphohistidine phosphatase, SixA
IXO1088_RS01235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO1088_RS01280	COG1968	undecaprenyl-diphosphatase activity
IXO1088_RS01285	COG0174	glutamine synthetase
IXO1088_RS01290	COG0347	Belongs to the P(II) protein family
IXO1088_RS01295	COG0004	ammonium transporteR
IXO1088_RS01300	COG3852	Histidine kinase
IXO1088_RS01305	COG2204	response regulator
IXO1088_RS01310	COG2032	superoxide dismutase activity
IXO1088_RS01315	COG2032	superoxide dismutase activity
IXO1088_RS01380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO1088_RS01385	COG1074	ATP-dependent DNA helicase activity
IXO1088_RS01395	COG3549	Plasmid maintenance system killer
IXO1088_RS01470	COG1764	response to oxidative stress
IXO1088_RS01475	COG1846	Transcriptional regulator
IXO1088_RS01520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO1088_RS01560	COG2211	Major facilitator Superfamily
IXO1088_RS01580	COG3693	PFAM glycoside hydrolase, family 10
IXO1088_RS01605	COG0246	Mannitol dehydrogenase
IXO1088_RS01610	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO1088_RS01620	COG4948	Mandelate Racemase Muconate Lactonizing
IXO1088_RS01630	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO1088_RS01645	COG0037	tRNA processing
IXO1088_RS01650	COG2974	May be involved in recombination
IXO1088_RS01675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO1088_RS01685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO1088_RS01695	COG0805	protein transport
IXO1088_RS01705	COG0519	Catalyzes the synthesis of GMP from XMP
IXO1088_RS01705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO1088_RS01720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO1088_RS01725	COG0752	glycyl-tRNA synthetase alpha subunit
IXO1088_RS01735	COG0457	Tetratricopeptide repeat
IXO1088_RS01740	COG4771	TonB-dependent receptor
IXO1088_RS01755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO1088_RS01765	COG0697	spore germination
IXO1088_RS01775	COG0523	cobalamin synthesis protein
IXO1088_RS01830	COG1960	acyl-CoA dehydrogenase activity
IXO1088_RS01835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO1088_RS01840	COG4770	biotin carboxylase activity
IXO1088_RS01885	COG2072	flavoprotein involved in K transport
IXO1088_RS01905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO1088_RS01950	COG0084	hydrolase, TatD family'
IXO1088_RS01965	COG0583	DNA-binding transcription factor activity
IXO1088_RS01970	COG2814	Major facilitator Superfamily
IXO1088_RS01980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO1088_RS01985	COG1902	pentaerythritol trinitrate reductase activity
IXO1088_RS02015	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS02035	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO1088_RS02040	COG0583	DNA-binding transcription factor activity
IXO1088_RS02070	COG0702	epimerase
IXO1088_RS02075	COG1733	regulation of RNA biosynthetic process
IXO1088_RS02125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO1088_RS02140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO1088_RS02175	COG2911	Protein conserved in bacteria
IXO1088_RS02180	COG0729	surface antigen
IXO1088_RS02195	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO1088_RS02200	COG3118	belongs to the thioredoxin family
IXO1088_RS02210	COG2884	Cell division ATP-binding protein ftsE
IXO1088_RS02215	COG2177	Part of the ABC transporter FtsEX involved in
IXO1088_RS02220	COG2201	protein-glutamate methylesterase activity
IXO1088_RS02225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO1088_RS02230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO1088_RS02240	COG1252	NADH dehydrogenase
IXO1088_RS02265	COG0459	protein refolding
IXO1088_RS02275	COG4771	TonB-dependent receptor
IXO1088_RS02290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO1088_RS02335	COG3386	PFAM SMP-30 Gluconolaconase
IXO1088_RS02350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO1088_RS02375	COG0778	Nitroreductase
IXO1088_RS02380	COG2353	YceI-like domain
IXO1088_RS02475	COG0408	coproporphyrinogen oxidase activity
IXO1088_RS02485	COG3039	Transposase
IXO1088_RS02505	COG0129	dihydroxy-acid dehydratase activity
IXO1088_RS02515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO1088_RS02545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO1088_RS02550	COG0318	PFAM AMP-dependent synthetase and ligase
IXO1088_RS02555	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO1088_RS02560	COG0596	Alpha beta hydrolase
IXO1088_RS02575	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IXO1088_RS02580	COG3177	Filamentation induced by cAMP protein fic
IXO1088_RS02585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO1088_RS02600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO1088_RS02625	COG4191	Histidine kinase
IXO1088_RS02645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO1088_RS02650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO1088_RS02675	COG5383	Protein conserved in bacteria
IXO1088_RS02690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO1088_RS02695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO1088_RS02700	COG1473	amidohydrolase
IXO1088_RS02710	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO1088_RS02710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO1088_RS02800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO1088_RS02815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO1088_RS02820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO1088_RS02830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO1088_RS02835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO1088_RS02840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO1088_RS02890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO1088_RS02905	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO1088_RS02980	COG3039	Transposase
IXO1088_RS03000	COG1294	oxidase, subunit
IXO1088_RS03005	COG1271	oxidase subunit
IXO1088_RS03060	COG2972	Histidine kinase
IXO1088_RS03075	COG0531	amino acid
IXO1088_RS03095	COG3590	peptidase
IXO1088_RS03105	COG0667	Aldo Keto reductase
IXO1088_RS03120	COG3384	dioxygenase
IXO1088_RS03130	COG1573	uracil-dna glycosylase
IXO1088_RS03140	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO1088_RS03155	COG0025	NhaP-type Na H and K H
IXO1088_RS03160	COG1131	(ABC) transporter
IXO1088_RS03165	COG0842	Transport permease protein
IXO1088_RS03180	COG1404	Belongs to the peptidase S8 family
IXO1088_RS03195	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS03245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO1088_RS03270	COG2202	Pas domain
IXO1088_RS03270	COG2205	protein histidine kinase activity
IXO1088_RS03300	COG2813	Specifically methylates the guanine in position
IXO1088_RS03305	COG1187	pseudouridine synthase activity
IXO1088_RS03310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO1088_RS03345	COG0697	spore germination
IXO1088_RS03355	COG2011	ABC-type metal ion transport system permease component
IXO1088_RS03385	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO1088_RS03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO1088_RS03415	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO1088_RS03425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO1088_RS03435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO1088_RS03440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO1088_RS03445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO1088_RS03450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO1088_RS03500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO1088_RS03505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO1088_RS03555	COG0339	signal peptide processing
IXO1088_RS03590	COG1956	GAF domain-containing protein
IXO1088_RS03595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO1088_RS03605	COG0720	synthase
IXO1088_RS03610	COG0513	Belongs to the DEAD box helicase family
IXO1088_RS03625	COG0625	glutathione transferase activity
IXO1088_RS03655	COG0626	cystathionine gamma-synthase activity
IXO1088_RS03700	COG3328	transposase activity
IXO1088_RS03725	COG2086	electron transfer activity
IXO1088_RS03750	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO1088_RS03750	COG0662	Cupin 2, conserved barrel domain protein
IXO1088_RS03755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO1088_RS03790	COG3218	ABC-type transport auxiliary lipoprotein component
IXO1088_RS03790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO1088_RS03795	COG1127	ABC transporter
IXO1088_RS03800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO1088_RS03815	COG0442	prolyl-tRNA aminoacylation
IXO1088_RS03825	COG1183	phosphatidylcholine synthase activity
IXO1088_RS03855	COG3039	Transposase
IXO1088_RS03880	COG3039	Transposase
IXO1088_RS03910	COG0525	valine-tRNA ligase activity
IXO1088_RS03925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO1088_RS03935	COG0795	lipopolysaccharide-transporting ATPase activity
IXO1088_RS03950	COG4974	Belongs to the 'phage' integrase family
IXO1088_RS03955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO1088_RS03960	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO1088_RS03960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO1088_RS03965	COG5295	Hep Hag repeat protein
IXO1088_RS03975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO1088_RS03985	COG1459	type II secretion system
IXO1088_RS03990	COG2165	general secretion pathway protein
IXO1088_RS03995	COG4970	Tfp pilus assembly protein FimT
IXO1088_RS04000	COG2165	general secretion pathway protein
IXO1088_RS04005	COG4795	General secretion pathway protein
IXO1088_RS04010	COG3156	type II secretion system protein K
IXO1088_RS04015	COG3166	PFAM Fimbrial assembly family protein
IXO1088_RS04030	COG1450	Type ii and iii secretion system protein
IXO1088_RS04040	COG2188	Transcriptional regulator
IXO1088_RS04090	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO1088_RS04095	COG1518	maintenance of DNA repeat elements
IXO1088_RS04140	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO1088_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS04170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO1088_RS04180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO1088_RS04185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO1088_RS04215	COG3829	transcription factor binding
IXO1088_RS04315	COG2826	transposase and inactivated derivatives, IS30 family
IXO1088_RS04325	COG0678	peroxiredoxin activity
IXO1088_RS04345	COG0330	HflC and HflK could
IXO1088_RS04350	COG0330	HflC and HflK could
IXO1088_RS04360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO1088_RS04365	COG0308	aminopeptidase N
IXO1088_RS04410	COG1560	Kdo2-lipid A biosynthetic process
IXO1088_RS04415	COG1519	Transferase
IXO1088_RS04420	COG1538	Outer membrane efflux protein
IXO1088_RS04425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO1088_RS04455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO1088_RS04460	COG0066	3-isopropylmalate dehydratase activity
IXO1088_RS04495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO1088_RS04505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO1088_RS04510	COG3710	Transcriptional regulator
IXO1088_RS04535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO1088_RS04545	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO1088_RS04555	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO1088_RS04585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO1088_RS04595	COG3781	membrane
IXO1088_RS04750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO1088_RS04775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO1088_RS04810	COG3039	Transposase
IXO1088_RS04830	COG0584	glycerophosphoryl diester phosphodiesterase
IXO1088_RS04860	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO1088_RS04860	COG1902	pentaerythritol trinitrate reductase activity
IXO1088_RS04865	COG0604	alcohol dehydrogenase
IXO1088_RS04890	COG0156	8-amino-7-oxononanoate synthase activity
IXO1088_RS04895	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO1088_RS04900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO1088_RS04905	COG4208	sulfate ABC transporter
IXO1088_RS04910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO1088_RS04940	COG0588	phosphoglycerate mutase activity
IXO1088_RS04950	COG0285	dihydrofolate synthase activity
IXO1088_RS04970	COG2833	Protein of unknown function (DUF455)
IXO1088_RS04990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO1088_RS04995	COG0671	phosphoesterase, PA-phosphatase related
IXO1088_RS05000	COG0438	transferase activity, transferring glycosyl groups
IXO1088_RS05010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO1088_RS05025	COG4783	chaperone-mediated protein folding
IXO1088_RS05050	COG0473	3-isopropylmalate dehydrogenase activity
IXO1088_RS05100	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO1088_RS05140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO1088_RS05165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO1088_RS05175	COG0631	protein serine/threonine phosphatase activity
IXO1088_RS05200	COG3501	Rhs element vgr protein
IXO1088_RS05230	COG0582	viral genome integration into host DNA
IXO1088_RS05240	COG0859	PFAM glycosyl transferase family 9
IXO1088_RS05245	COG3642	lipopolysaccharide core region biosynthetic process
IXO1088_RS05250	COG1234	tRNA 3'-trailer cleavage
IXO1088_RS05255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO1088_RS05265	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO1088_RS05270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO1088_RS05275	COG0314	molybdopterin synthase activity
IXO1088_RS05305	COG0537	adenosine 5'-monophosphoramidase activity
IXO1088_RS05325	COG0714	Associated with various cellular activities
IXO1088_RS05345	COG0242	peptide deformylase activity
IXO1088_RS05395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO1088_RS05400	COG0726	polysaccharide deacetylase
IXO1088_RS05425	COG1162	GTPase activity
IXO1088_RS05460	COG1609	Transcriptional regulator
IXO1088_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS05470	COG2851	Citrate transporter
IXO1088_RS05485	COG0642	Histidine kinase
IXO1088_RS05495	COG2197	response regulator
IXO1088_RS05510	COG0583	DNA-binding transcription factor activity
IXO1088_RS05525	COG4191	Histidine kinase
IXO1088_RS05545	COG0281	malic enzyme
IXO1088_RS05545	COG0280	phosphate acetyltransferase
IXO1088_RS05605	COG0352	thiamine-phosphate diphosphorylase activity
IXO1088_RS05610	COG1773	rubredoxin
IXO1088_RS05615	COG2912	Transglutaminase-like superfamily
IXO1088_RS05625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO1088_RS05635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO1088_RS05660	COG0006	proline dipeptidase activity
IXO1088_RS05695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO1088_RS05705	COG0346	lactoylglutathione lyase activity
IXO1088_RS05710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO1088_RS05715	COG1561	YicC-like family, N-terminal region
IXO1088_RS05740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO1088_RS05750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO1088_RS05775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO1088_RS05815	COG0714	Associated with various cellular activities
IXO1088_RS05835	COG2304	oxidoreductase activity
IXO1088_RS05855	COG1301	dicarboxylic acid transport
IXO1088_RS05860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO1088_RS05870	COG0739	heme binding
IXO1088_RS05875	COG1376	ErfK ybiS ycfS ynhG family protein
IXO1088_RS05900	COG1022	Amp-dependent synthetase and ligase
IXO1088_RS05910	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS05920	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS05925	COG0642	Histidine kinase
IXO1088_RS05945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO1088_RS05950	COG4149	molybdate abc transporter
IXO1088_RS05955	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO1088_RS05960	COG3453	Protein conserved in bacteria
IXO1088_RS05960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO1088_RS06000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO1088_RS06020	COG2205	protein histidine kinase activity
IXO1088_RS06025	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS06045	COG3039	Transposase
IXO1088_RS06080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO1088_RS06085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO1088_RS06140	COG3039	Transposase
IXO1088_RS06145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO1088_RS06170	COG2201	protein-glutamate methylesterase activity
IXO1088_RS06250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO1088_RS06260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO1088_RS06265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO1088_RS06280	COG1842	Phage shock protein A
IXO1088_RS06305	COG0754	glutathionylspermidine amidase activity
IXO1088_RS06365	COG0531	amino acid
IXO1088_RS06370	COG2197	response regulator
IXO1088_RS06385	COG1113	amino acid transport
IXO1088_RS06400	COG1271	oxidase subunit
IXO1088_RS06405	COG1294	oxidase, subunit
IXO1088_RS06415	COG2239	Acts as a magnesium transporter
IXO1088_RS06420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO1088_RS06425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO1088_RS06435	COG1660	Displays ATPase and GTPase activities
IXO1088_RS06440	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO1088_RS06445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO1088_RS06460	COG1137	ATPase activity
IXO1088_RS06465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO1088_RS06475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO1088_RS06485	COG0271	Belongs to the BolA IbaG family
IXO1088_RS06490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO1088_RS06510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO1088_RS06525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO1088_RS06535	COG0628	permease
IXO1088_RS06545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO1088_RS06550	COG3178	'Phosphotransferase
IXO1088_RS06565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO1088_RS06570	COG1555	photosystem II stabilization
IXO1088_RS06585	COG3039	Transposase
IXO1088_RS06625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO1088_RS06635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO1088_RS06655	COG0228	four-way junction DNA binding
IXO1088_RS06660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO1088_RS06665	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO1088_RS06680	COG0534	Mate efflux family protein
IXO1088_RS06715	COG0542	response to heat
IXO1088_RS06750	COG4206	TonB-dependent receptor
IXO1088_RS06815	COG0019	diaminopimelate decarboxylase activity
IXO1088_RS06825	COG2814	Major facilitator Superfamily
IXO1088_RS06830	COG4264	IucA IucC family
IXO1088_RS06840	COG4772	TonB-dependent receptor
IXO1088_RS06855	COG4651	solute:proton antiporter activity
IXO1088_RS06855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO1088_RS06880	COG0488	(ABC) transporter
IXO1088_RS06905	COG2755	lipolytic protein G-D-S-L family
IXO1088_RS06905	COG0657	acetylesterase activity
IXO1088_RS06930	COG2207	Transcriptional regulator
IXO1088_RS06935	COG0326	Molecular chaperone. Has ATPase activity
IXO1088_RS06960	COG3328	transposase activity
IXO1088_RS06965	COG0174	glutamine synthetase
IXO1088_RS06970	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO1088_RS06980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO1088_RS06995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO1088_RS07030	COG2146	nitrite reductase [NAD(P)H] activity
IXO1088_RS07040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO1088_RS07045	COG0719	Fe-S assembly protein
IXO1088_RS07050	COG0396	ATPase activity
IXO1088_RS07055	COG0719	Fe-S assembly protein
IXO1088_RS07060	COG1959	2 iron, 2 sulfur cluster binding
IXO1088_RS07080	COG0693	protein deglycase activity
IXO1088_RS07120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO1088_RS07150	COG0519	Catalyzes the synthesis of GMP from XMP
IXO1088_RS07160	COG1678	Uncharacterized ACR, COG1678
IXO1088_RS07165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO1088_RS07180	COG1764	response to oxidative stress
IXO1088_RS07190	COG0384	phenazine biosynthesis protein PhzF
IXO1088_RS07200	COG0527	aspartate kinase activity
IXO1088_RS07225	COG0142	geranyltranstransferase activity
IXO1088_RS07230	COG0629	single-stranded DNA binding
IXO1088_RS07285	COG2879	small protein
IXO1088_RS07290	COG1966	Carbon starvation protein
IXO1088_RS07295	COG1741	Belongs to the pirin family
IXO1088_RS07305	COG3501	Rhs element vgr protein
IXO1088_RS07350	COG3179	chitinase
IXO1088_RS07355	COG3501	Rhs element vgr protein
IXO1088_RS07365	COG3328	transposase activity
IXO1088_RS07380	COG3179	chitinase
IXO1088_RS07420	COG3501	Rhs element vgr protein
IXO1088_RS07485	COG3501	Rhs element vgr protein
IXO1088_RS07570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO1088_RS07580	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO1088_RS07615	COG0732	type I restriction modification DNA specificity domain
IXO1088_RS07700	COG0587	DNA-directed DNA polymerase activity
IXO1088_RS07715	COG1297	OPT oligopeptide transporter protein
IXO1088_RS07735	COG0823	Involved in the tonB-independent uptake of proteins
IXO1088_RS07735	COG1506	peptidase
IXO1088_RS07755	COG1917	Cupin 2, conserved barrel domain protein
IXO1088_RS07755	COG2207	Transcriptional regulator
IXO1088_RS07780	COG0753	catalase activity
IXO1088_RS07810	COG0126	phosphoglycerate kinase activity
IXO1088_RS07820	COG0469	pyruvate kinase activity
IXO1088_RS07825	COG3588	fructose-bisphosphate aldolase
IXO1088_RS07830	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO1088_RS07875	COG0784	Response regulator, receiver
IXO1088_RS07875	COG2205	protein histidine kinase activity
IXO1088_RS07875	COG2198	Histidine kinase
IXO1088_RS07895	COG0175	sulfate reduction
IXO1088_RS07900	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO1088_RS07905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO1088_RS07910	COG0175	sulfate reduction
IXO1088_RS07915	COG0529	Catalyzes the synthesis of activated sulfate
IXO1088_RS07915	COG2895	sulfate adenylyltransferase (ATP) activity
IXO1088_RS07925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO1088_RS07930	COG0308	aminopeptidase N
IXO1088_RS07950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO1088_RS07975	COG1970	mechanosensitive ion channel activity
IXO1088_RS08005	COG0471	metal ion transport
IXO1088_RS08005	COG3273	potassium ion transport
IXO1088_RS08015	COG2022	thiamine diphosphate biosynthetic process
IXO1088_RS08180	COG0632	four-way junction helicase activity
IXO1088_RS08190	COG2255	four-way junction helicase activity
IXO1088_RS08195	COG0824	Thioesterase
IXO1088_RS08205	COG0848	biopolymer transport protein
IXO1088_RS08220	COG2885	chlorophyll binding
IXO1088_RS08230	COG0602	queuosine metabolic process
IXO1088_RS08255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO1088_RS08275	COG0514	ATP-dependent DNA helicase (RecQ)
IXO1088_RS08280	COG0783	Belongs to the Dps family
IXO1088_RS08285	COG1643	Atp-dependent helicase
IXO1088_RS08310	COG0535	radical SAM domain protein
IXO1088_RS08315	COG0535	radical SAM domain protein
IXO1088_RS08320	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IXO1088_RS08335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO1088_RS08345	COG1215	transferase activity, transferring glycosyl groups
IXO1088_RS08350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO1088_RS08360	COG1199	ATP-dependent helicase activity
IXO1088_RS08370	COG1397	ADP-ribosylglycohydrolase
IXO1088_RS08380	COG0189	ligase activity
IXO1088_RS08395	COG0835	chemotaxis
IXO1088_RS08400	COG0840	transmembrane signaling receptor activity
IXO1088_RS08405	COG0643	Histidine kinase
IXO1088_RS08405	COG0784	Response regulator, receiver
IXO1088_RS08405	COG2198	Histidine kinase
IXO1088_RS08445	COG1446	asparaginase
IXO1088_RS08490	COG3537	Alpha-1,2-mannosidase
IXO1088_RS08550	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO1088_RS08560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO1088_RS08570	COG1388	LysM domain
IXO1088_RS08570	COG3858	chitin binding
IXO1088_RS08585	COG0837	glucose binding
IXO1088_RS08590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO1088_RS08600	COG0494	nUDIX hydrolase
IXO1088_RS08610	COG3956	TIGRFAM MazG family protein
IXO1088_RS08625	COG0330	HflC and HflK could
IXO1088_RS08640	COG0509	glycine decarboxylation via glycine cleavage system
IXO1088_RS08675	COG1960	acyl-CoA dehydrogenase activity
IXO1088_RS08685	COG1309	transcriptional regulator
IXO1088_RS08690	COG4771	TonB-dependent receptor
IXO1088_RS08700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO1088_RS08710	COG0463	Glycosyl transferase, family 2
IXO1088_RS08730	COG1272	protein, Hemolysin III
IXO1088_RS08735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IXO1088_RS08740	COG0739	heme binding
IXO1088_RS08745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO1088_RS08750	COG0626	cystathionine gamma-synthase activity
IXO1088_RS08760	COG1760	l-serine dehydratase
IXO1088_RS08775	COG2353	YceI-like domain
IXO1088_RS08785	COG2353	YceI-like domain
IXO1088_RS08855	COG1960	acyl-CoA dehydrogenase activity
IXO1088_RS08860	COG1024	Enoyl-CoA hydratase
IXO1088_RS08880	COG1024	Enoyl-CoA hydratase
IXO1088_RS08880	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO1088_RS08895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO1088_RS08900	COG0481	GTPase activity
IXO1088_RS08925	COG1381	Involved in DNA repair and RecF pathway recombination
IXO1088_RS08940	COG2954	triphosphatase activity
IXO1088_RS08955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO1088_RS08960	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO1088_RS08965	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO1088_RS08980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO1088_RS08985	COG1278	Cold shock
IXO1088_RS09005	COG1201	RNA secondary structure unwinding
IXO1088_RS09010	COG1793	dna ligase
IXO1088_RS09020	COG1793	dna ligase
IXO1088_RS09020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO1088_RS09050	COG0183	Belongs to the thiolase family
IXO1088_RS09070	COG1451	nucleotide metabolic process
IXO1088_RS09090	COG3039	Transposase
IXO1088_RS09095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO1088_RS09150	COG1047	Peptidyl-prolyl cis-trans
IXO1088_RS09165	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO1088_RS09175	COG1902	pentaerythritol trinitrate reductase activity
IXO1088_RS09180	COG2814	Major facilitator Superfamily
IXO1088_RS09215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO1088_RS09215	COG0392	lysyltransferase activity
IXO1088_RS09225	COG0251	oxidation-reduction process
IXO1088_RS09230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO1088_RS09245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO1088_RS09270	COG1595	DNA-templated transcription, initiation
IXO1088_RS09285	COG2878	Part of a membrane complex involved in electron transport
IXO1088_RS09295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO1088_RS09295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO1088_RS09315	COG0833	amino acid
IXO1088_RS09320	COG2040	homocysteine
IXO1088_RS09335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO1088_RS09370	COG0529	Catalyzes the synthesis of activated sulfate
IXO1088_RS09370	COG2895	sulfate adenylyltransferase (ATP) activity
IXO1088_RS09445	COG4771	TonB-dependent receptor
IXO1088_RS09455	COG0825	malonyl-CoA metabolic process
IXO1088_RS09475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO1088_RS09480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO1088_RS09500	COG0750	zinc metalloprotease
IXO1088_RS09510	COG0575	Belongs to the CDS family
IXO1088_RS09520	COG0233	cytoplasmic translational termination
IXO1088_RS09535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO1088_RS09595	COG1393	Belongs to the ArsC family
IXO1088_RS09610	COG0367	asparagine synthase
IXO1088_RS09620	COG4774	siderophore transport
IXO1088_RS09645	COG2207	Transcriptional regulator
IXO1088_RS09660	COG1566	PFAM secretion protein HlyD family protein
IXO1088_RS09665	COG2814	Major facilitator Superfamily
IXO1088_RS09710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO1088_RS09720	COG1960	acyl-CoA dehydrogenase activity
IXO1088_RS09735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO1088_RS09745	COG2914	Belongs to the UPF0125 (RnfH) family
IXO1088_RS09750	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO1088_RS09760	COG0497	DNA recombination
IXO1088_RS09770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO1088_RS09775	COG0443	Heat shock 70 kDa protein
IXO1088_RS09780	COG0484	heat shock protein binding
IXO1088_RS09785	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO1088_RS09805	COG0583	DNA-binding transcription factor activity
IXO1088_RS09820	COG1132	(ABC) transporter
IXO1088_RS09855	COG2850	peptidyl-arginine hydroxylation
IXO1088_RS09935	COG1131	(ABC) transporter
IXO1088_RS09940	COG1725	Transcriptional regulator
IXO1088_RS09950	COG0386	Belongs to the glutathione peroxidase family
IXO1088_RS09965	COG2900	Belongs to the SlyX family
IXO1088_RS09990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO1088_RS10005	COG0646	methionine synthase
IXO1088_RS10005	COG1410	methionine synthase
IXO1088_RS10010	COG0646	methionine synthase
IXO1088_RS10010	COG1410	methionine synthase
IXO1088_RS10015	COG2226	methyltransferase
IXO1088_RS10020	COG1960	acyl-CoA dehydrogenase activity
IXO1088_RS10045	COG0557	exoribonuclease II activity
IXO1088_RS10060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO1088_RS10070	COG3039	Transposase
IXO1088_RS10100	COG1278	Cold shock
IXO1088_RS10180	COG3039	Transposase
IXO1088_RS10190	COG0583	DNA-binding transcription factor activity
IXO1088_RS10255	COG0742	ribosomal rna small subunit methyltransferase
IXO1088_RS10260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO1088_RS10275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO1088_RS10280	COG0405	Gamma-glutamyltransferase
IXO1088_RS10350	COG3501	Rhs element vgr protein
IXO1088_RS10370	COG3501	Rhs element vgr protein
IXO1088_RS10395	COG3039	Transposase
IXO1088_RS10435	COG0343	queuine tRNA-ribosyltransferase activity
IXO1088_RS10440	COG1862	Preprotein translocase
IXO1088_RS10445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO1088_RS10450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO1088_RS10480	COG3328	transposase activity
IXO1088_RS10495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO1088_RS10505	COG0704	Plays a role in the regulation of phosphate uptake
IXO1088_RS10520	COG0573	inorganic phosphate transmembrane transporter activity
IXO1088_RS10525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO1088_RS10560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO1088_RS10570	COG1024	Enoyl-CoA hydratase
IXO1088_RS10585	COG0494	nUDIX hydrolase
IXO1088_RS10630	COG0116	Belongs to the methyltransferase superfamily
IXO1088_RS10630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO1088_RS10655	COG0667	Aldo Keto reductase
IXO1088_RS10665	COG2925	Exonuclease
IXO1088_RS10700	COG0288	reversible hydration of carbon dioxide
IXO1088_RS10730	COG0316	Belongs to the HesB IscA family
IXO1088_RS10735	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO1088_RS10745	COG0359	binds to the 23S rRNA
IXO1088_RS10755	COG3115	cell septum assembly
IXO1088_RS10775	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO1088_RS10790	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO1088_RS10815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO1088_RS10825	COG2986	histidine ammonia-lyase
IXO1088_RS10830	COG1228	amidohydrolase
IXO1088_RS10870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO1088_RS10880	COG1605	Chorismate mutase
IXO1088_RS10880	COG0077	Prephenate dehydratase
IXO1088_RS10885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO1088_RS10915	COG4566	intracellular signal transduction
IXO1088_RS10960	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO1088_RS10965	COG1469	GTP cyclohydrolase I activity
IXO1088_RS10975	COG0617	tRNA 3'-terminal CCA addition
IXO1088_RS10985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO1088_RS10990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO1088_RS11020	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO1088_RS11040	COG5001	Diguanylate cyclase
IXO1088_RS11040	COG4251	negative regulation of phosphorylation
IXO1088_RS11040	COG3706	GGDEF domain
IXO1088_RS11040	COG2203	Gaf domain
IXO1088_RS11125	COG0386	Belongs to the glutathione peroxidase family
IXO1088_RS11190	COG3706	GGDEF domain
IXO1088_RS11215	COG1247	-acetyltransferase
IXO1088_RS11235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IXO1088_RS11240	COG3039	Transposase
IXO1088_RS11250	COG3039	Transposase
IXO1088_RS11275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO1088_RS11290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO1088_RS11295	COG1393	Belongs to the ArsC family
IXO1088_RS11300	COG0431	NADPH-dependent FMN reductase
IXO1088_RS11305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IXO1088_RS11310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO1088_RS11330	COG5002	protein histidine kinase activity
IXO1088_RS11330	COG2205	protein histidine kinase activity
IXO1088_RS11330	COG0784	Response regulator, receiver
IXO1088_RS11370	COG0800	Aldolase
IXO1088_RS11375	COG0129	dihydroxy-acid dehydratase activity
IXO1088_RS11380	COG0363	glucosamine-6-phosphate deaminase activity
IXO1088_RS11390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO1088_RS11405	COG0354	folic acid binding
IXO1088_RS11420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO1088_RS11435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO1088_RS11450	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO1088_RS11475	COG0811	peptide transport
IXO1088_RS11490	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO1088_RS11500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO1088_RS11510	COG0322	excinuclease ABC activity
IXO1088_RS11560	COG2801	Transposase and inactivated derivatives
IXO1088_RS11600	COG0653	protein targeting
IXO1088_RS11745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO1088_RS11745	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO1088_RS11755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO1088_RS11765	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO1088_RS11765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO1088_RS11780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO1088_RS11810	COG0124	histidyl-tRNA synthetase
IXO1088_RS11825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO1088_RS11860	COG1012	belongs to the aldehyde dehydrogenase family
IXO1088_RS11890	COG0697	spore germination
IXO1088_RS11895	COG1794	racemase activity, acting on amino acids and derivatives
IXO1088_RS11920	COG0671	phosphoesterase, PA-phosphatase related
IXO1088_RS11935	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO1088_RS11950	COG2183	response to ionizing radiation
IXO1088_RS11960	COG0723	plastoquinol--plastocyanin reductase activity
IXO1088_RS11960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO1088_RS11975	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO1088_RS11985	COG1183	phosphatidylcholine synthase activity
IXO1088_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS12005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IXO1088_RS12015	COG0668	transmembrane transport
IXO1088_RS12035	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO1088_RS12080	COG0583	DNA-binding transcription factor activity
IXO1088_RS12085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO1088_RS12090	COG3002	Belongs to the UPF0753 family
IXO1088_RS12105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO1088_RS12125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO1088_RS12135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO1088_RS12140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO1088_RS12150	COG0776	regulation of translation
IXO1088_RS12155	COG0539	negative regulation of cytoplasmic translation
IXO1088_RS12160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO1088_RS12175	COG2957	Belongs to the agmatine deiminase family
IXO1088_RS12185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO1088_RS12210	COG0395	ABC-type sugar transport system, permease component
IXO1088_RS12215	COG1175	transmembrane transport
IXO1088_RS12255	COG2350	Protein conserved in bacteria
IXO1088_RS12260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO1088_RS12265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO1088_RS12270	COG1187	pseudouridine synthase activity
IXO1088_RS12295	COG0436	Aminotransferase
IXO1088_RS12300	COG4133	protoheme IX ABC transporter activity
IXO1088_RS12360	COG0277	FAD linked oxidase domain protein
IXO1088_RS12365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO1088_RS12375	COG0531	amino acid
IXO1088_RS12380	COG0531	amino acid
IXO1088_RS12390	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO1088_RS12420	COG3039	Transposase
IXO1088_RS12435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO1088_RS12505	COG0303	'Molybdopterin
IXO1088_RS12510	COG1160	GTP binding
IXO1088_RS12515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO1088_RS12525	COG1426	Protein conserved in bacteria
IXO1088_RS12535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO1088_RS12550	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO1088_RS12550	COG1024	Enoyl-CoA hydratase
IXO1088_RS12555	COG0183	Belongs to the thiolase family
IXO1088_RS12565	COG0038	chloride channel
IXO1088_RS12585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO1088_RS12605	COG1674	ftsk spoiiie
IXO1088_RS12610	COG0492	ferredoxin-NADP+ reductase activity
IXO1088_RS12635	COG0542	response to heat
IXO1088_RS12650	COG0482	sulfurtransferase activity
IXO1088_RS12675	COG5001	Diguanylate cyclase
IXO1088_RS12680	COG4585	Histidine kinase
IXO1088_RS12690	COG5002	protein histidine kinase activity
IXO1088_RS12710	COG0835	chemotaxis
IXO1088_RS12710	COG0784	Response regulator, receiver
IXO1088_RS12720	COG1558	bacterial-type flagellum-dependent cell motility
IXO1088_RS12725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO1088_RS12735	COG4787	bacterial-type flagellum-dependent cell motility
IXO1088_RS12775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO1088_RS12780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO1088_RS12810	COG2201	protein-glutamate methylesterase activity
IXO1088_RS12830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO1088_RS12840	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS12870	COG1677	Flagellar hook-basal body complex protein FliE
IXO1088_RS12920	COG3190	flagellar
IXO1088_RS12935	COG1684	flagellar biosynthetic protein fliR
IXO1088_RS12940	COG5001	Diguanylate cyclase
IXO1088_RS12940	COG3300	MHYT domain
IXO1088_RS12945	COG5001	Diguanylate cyclase
IXO1088_RS12945	COG3300	MHYT domain
IXO1088_RS12990	COG2198	Histidine kinase
IXO1088_RS12990	COG0643	Histidine kinase
IXO1088_RS12990	COG0784	Response regulator, receiver
IXO1088_RS13020	COG3209	COG3209 Rhs family protein
IXO1088_RS13120	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO1088_RS13125	COG4988	ABC transporter
IXO1088_RS13135	COG1271	oxidase subunit
IXO1088_RS13165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO1088_RS13185	COG0165	Argininosuccinate lyase
IXO1088_RS13200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO1088_RS13205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO1088_RS13215	COG0137	argininosuccinate synthase activity
IXO1088_RS13220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO1088_RS13235	COG2166	iron-sulfur cluster assembly
IXO1088_RS13260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO1088_RS13290	COG3039	Transposase
IXO1088_RS13310	COG4677	pectinesterase activity
IXO1088_RS13335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO1088_RS13340	COG0402	S-adenosylhomocysteine deaminase activity
IXO1088_RS13355	COG1509	lysine 2,3-aminomutase activity
IXO1088_RS13360	COG5001	Diguanylate cyclase
IXO1088_RS13360	COG3300	MHYT domain
IXO1088_RS13375	COG0483	inositol monophosphate 1-phosphatase activity
IXO1088_RS13380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO1088_RS13405	COG0513	Belongs to the DEAD box helicase family
IXO1088_RS13410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO1088_RS13425	COG0625	glutathione transferase activity
IXO1088_RS13430	COG1278	Cold shock
IXO1088_RS13435	COG1671	Belongs to the UPF0178 family
IXO1088_RS13440	COG4681	YaeQ
IXO1088_RS13445	COG2081	HI0933 family
IXO1088_RS13455	COG0501	Belongs to the peptidase M48B family
IXO1088_RS13465	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS13485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO1088_RS13490	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO1088_RS13495	COG0802	atpase or kinase
IXO1088_RS13500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO1088_RS13500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO1088_RS13505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO1088_RS13525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO1088_RS13605	COG3328	transposase activity
IXO1088_RS13640	COG2969	positive regulation of protein catabolic process
IXO1088_RS13645	COG0625	glutathione transferase activity
IXO1088_RS13650	COG2857	Cytochrome c1
IXO1088_RS13655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO1088_RS13660	COG0723	plastoquinol--plastocyanin reductase activity
IXO1088_RS13665	COG0741	lytic transglycosylase activity
IXO1088_RS13685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IXO1088_RS13690	COG1702	phosphate starvation-inducible protein PhoH
IXO1088_RS13710	COG4535	Mg2 and Co2 transporter CorC
IXO1088_RS13725	COG1012	belongs to the aldehyde dehydrogenase family
IXO1088_RS13735	COG1177	transmembrane transport
IXO1088_RS13745	COG3842	ATPase activity
IXO1088_RS13780	COG0174	glutamine synthetase
IXO1088_RS13785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO1088_RS13795	COG0477	Major facilitator Superfamily
IXO1088_RS13805	COG0243	molybdopterin cofactor binding
IXO1088_RS13815	COG2223	nitrite transmembrane transporter activity
IXO1088_RS13825	COG1121	(ABC) transporter
IXO1088_RS13835	COG2733	membrane
IXO1088_RS13840	COG5002	protein histidine kinase activity
IXO1088_RS13840	COG2205	protein histidine kinase activity
IXO1088_RS13840	COG0784	Response regulator, receiver
IXO1088_RS13850	COG3039	Transposase
IXO1088_RS13855	COG2902	Dehydrogenase
IXO1088_RS13865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO1088_RS13870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO1088_RS13890	COG1609	Transcriptional regulator
IXO1088_RS13895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO1088_RS13895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO1088_RS13900	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO1088_RS13905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO1088_RS13905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO1088_RS13920	COG3039	Transposase
IXO1088_RS13940	COG3039	Transposase
IXO1088_RS13995	COG3501	Rhs element vgr protein
IXO1088_RS14030	COG3039	Transposase
IXO1088_RS14080	COG4771	TonB-dependent receptor
IXO1088_RS14090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO1088_RS14110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO1088_RS14115	COG1360	Flagellar Motor Protein
IXO1088_RS14125	COG0835	chemotaxis
IXO1088_RS14135	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS14165	COG0840	transmembrane signaling receptor activity
IXO1088_RS14175	COG0840	transmembrane signaling receptor activity
IXO1088_RS14185	COG0840	transmembrane signaling receptor activity
IXO1088_RS14195	COG0840	transmembrane signaling receptor activity
IXO1088_RS14200	COG0840	transmembrane signaling receptor activity
IXO1088_RS14205	COG0840	transmembrane signaling receptor activity
IXO1088_RS14210	COG0840	transmembrane signaling receptor activity
IXO1088_RS14225	COG0835	chemotaxis
IXO1088_RS14285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO1088_RS14315	COG0318	PFAM AMP-dependent synthetase and ligase
IXO1088_RS14320	COG1024	Enoyl-CoA hydratase
IXO1088_RS14325	COG2198	Histidine kinase
IXO1088_RS14325	COG2205	protein histidine kinase activity
IXO1088_RS14325	COG0784	Response regulator, receiver
IXO1088_RS14395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO1088_RS14405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO1088_RS14410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO1088_RS14420	COG0505	Belongs to the CarA family
IXO1088_RS14425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO1088_RS14435	COG2258	MOSC domain
IXO1088_RS14440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO1088_RS14490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO1088_RS14510	COG0477	Major facilitator Superfamily
IXO1088_RS14520	COG1070	Carbohydrate kinase
IXO1088_RS14530	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO1088_RS14545	COG0800	Aldolase
IXO1088_RS14550	COG4948	Mandelate Racemase Muconate Lactonizing
IXO1088_RS14560	COG3734	2-keto-3-deoxy-galactonokinase
IXO1088_RS14565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO1088_RS14575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO1088_RS14590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO1088_RS14595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO1088_RS14605	COG0351	phosphomethylpyrimidine kinase
IXO1088_RS14635	COG0583	DNA-binding transcription factor activity
IXO1088_RS14640	COG1741	Belongs to the pirin family
IXO1088_RS14665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO1088_RS14670	COG0305	Participates in initiation and elongation during chromosome replication
IXO1088_RS14690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO1088_RS14695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO1088_RS14700	COG2137	regulation of response to DNA damage stimulus
IXO1088_RS14705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO1088_RS14720	COG1546	Belongs to the CinA family
IXO1088_RS14725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO1088_RS14735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO1088_RS14740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO1088_RS14750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO1088_RS14755	COG1534	Rna-binding protein
IXO1088_RS14770	COG1238	metal cluster binding
IXO1088_RS14775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO1088_RS14780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO1088_RS14785	COG2840	Smr protein MutS2
IXO1088_RS14795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO1088_RS14805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO1088_RS14810	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO1088_RS14815	COG0148	phosphopyruvate hydratase activity
IXO1088_RS14825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO1088_RS14830	COG0504	CTP synthase activity
IXO1088_RS14855	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IXO1088_RS14860	COG0306	phosphate transporter
IXO1088_RS14870	COG1253	flavin adenine dinucleotide binding
IXO1088_RS14885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO1088_RS14895	COG0477	Major facilitator Superfamily
IXO1088_RS14905	COG1132	(ABC) transporter
IXO1088_RS14910	COG1136	(ABC) transporter
IXO1088_RS14925	COG0438	transferase activity, transferring glycosyl groups
IXO1088_RS14935	COG2264	protein methyltransferase activity
IXO1088_RS14965	COG2244	polysaccharide biosynthetic process
IXO1088_RS15015	COG1595	DNA-templated transcription, initiation
IXO1088_RS15030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO1088_RS15050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO1088_RS15110	COG2201	protein-glutamate methylesterase activity
IXO1088_RS15130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO1088_RS15135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO1088_RS15185	COG1858	cytochrome C peroxidase
IXO1088_RS15215	COG0515	serine threonine protein kinase
IXO1088_RS15220	COG0631	protein serine/threonine phosphatase activity
IXO1088_RS15255	COG3501	Rhs element vgr protein
IXO1088_RS15330	COG3039	Transposase
IXO1088_RS15360	COG3039	Transposase
IXO1088_RS15365	COG3039	Transposase
IXO1088_RS15390	COG0316	Belongs to the HesB IscA family
IXO1088_RS15390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO1088_RS15395	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO1088_RS15405	COG0428	transporter
IXO1088_RS15410	COG0428	transporter
IXO1088_RS15415	COG3064	Membrane
IXO1088_RS15425	COG1530	ribonuclease E activity
IXO1088_RS15465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO1088_RS15500	COG3039	Transposase
IXO1088_RS15535	COG1648	precorrin-2 dehydrogenase activity
IXO1088_RS15535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO1088_RS15560	COG0746	molybdenum cofactor guanylyltransferase activity
IXO1088_RS15585	COG3039	Transposase
IXO1088_RS15635	COG4206	TonB-dependent receptor
IXO1088_RS15665	COG0531	amino acid
IXO1088_RS15680	COG0006	proline dipeptidase activity
IXO1088_RS15690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO1088_RS15705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO1088_RS15710	COG3938	Belongs to the proline racemase family
IXO1088_RS15720	COG0552	protein localization to endoplasmic reticulum
IXO1088_RS15740	COG0784	Response regulator, receiver
IXO1088_RS15740	COG4191	Histidine kinase
IXO1088_RS15830	COG3040	lipid binding
IXO1088_RS15870	COG0438	transferase activity, transferring glycosyl groups
IXO1088_RS15880	COG0438	transferase activity, transferring glycosyl groups
IXO1088_RS15885	COG0438	transferase activity, transferring glycosyl groups
IXO1088_RS15940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO1088_RS15945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IXO1088_RS15955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO1088_RS15995	COG0556	nucleotide-excision repair
IXO1088_RS16000	COG4969	Belongs to the N-Me-Phe pilin family
IXO1088_RS16065	COG4695	Portal protein
IXO1088_RS16110	COG3179	chitinase
IXO1088_RS16310	COG1611	Belongs to the LOG family
IXO1088_RS16325	COG2095	MarC family integral membrane protein
IXO1088_RS16335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO1088_RS16370	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO1088_RS16375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO1088_RS16395	COG0195	Participates in both transcription termination and antitermination
IXO1088_RS16400	COG0779	Required for maturation of 30S ribosomal subunits
IXO1088_RS16410	COG1007	ATP synthesis coupled electron transport
IXO1088_RS16440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO1088_RS16445	COG1034	ATP synthesis coupled electron transport
IXO1088_RS16450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO1088_RS16455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO1088_RS16460	COG0649	NAD binding
IXO1088_RS16465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO1088_RS16475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO1088_RS16490	COG0149	triose-phosphate isomerase activity
IXO1088_RS16540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO1088_RS16545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO1088_RS16550	COG0159	tryptophan synthase activity
IXO1088_RS16560	COG0133	tryptophan synthase activity
IXO1088_RS16570	COG0135	phosphoribosylanthranilate isomerase activity
IXO1088_RS16575	COG0101	tRNA pseudouridine synthase activity
IXO1088_RS16595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO1088_RS16600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO1088_RS16605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO1088_RS16610	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO1088_RS16660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO1088_RS16665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IXO1088_RS16680	COG3039	Transposase
IXO1088_RS16845	COG3179	chitinase
IXO1088_RS16890	COG4695	Portal protein
IXO1088_RS16935	COG3039	Transposase
IXO1088_RS16945	COG0412	Dienelactone hydrolase
IXO1088_RS16965	COG0717	Belongs to the dCTP deaminase family
IXO1088_RS16970	COG0489	protein tyrosine kinase activity
IXO1088_RS17010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO1088_RS17015	COG2311	Membrane
IXO1088_RS17020	COG1047	Peptidyl-prolyl cis-trans
IXO1088_RS17025	COG0791	NLP P60 protein
IXO1088_RS17030	COG0791	NLP P60 protein
IXO1088_RS17050	COG1301	dicarboxylic acid transport
IXO1088_RS17055	COG1785	Belongs to the alkaline phosphatase family
IXO1088_RS17060	COG0037	tRNA processing
IXO1088_RS17065	COG1722	exodeoxyribonuclease VII activity
IXO1088_RS17070	COG0142	geranyltranstransferase activity
IXO1088_RS17095	COG0312	modulator of DNA gyrase
IXO1088_RS17100	COG3028	Belongs to the UPF0307 family
IXO1088_RS17105	COG0312	modulator of DNA gyrase
IXO1088_RS17115	COG3164	Protein of unknown function
IXO1088_RS17120	COG1530	ribonuclease E activity
IXO1088_RS17130	COG2968	Membrane
IXO1088_RS17135	COG3039	Transposase
IXO1088_RS17165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO1088_RS17190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO1088_RS17215	COG3118	belongs to the thioredoxin family
IXO1088_RS17275	COG3039	Transposase
IXO1088_RS17305	COG3039	Transposase
IXO1088_RS17335	COG3501	Rhs element vgr protein
IXO1088_RS17345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO1088_RS17350	COG1845	cytochrome c oxidase, subunit III
IXO1088_RS17355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO1088_RS17370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO1088_RS17375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO1088_RS17385	COG0196	riboflavin kinase activity
IXO1088_RS17390	COG0728	peptidoglycan biosynthetic process
IXO1088_RS17395	COG0268	Binds directly to 16S ribosomal RNA
IXO1088_RS17400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO1088_RS17405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO1088_RS17415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO1088_RS17420	COG0824	Thioesterase
IXO1088_RS17435	COG1946	Acyl-CoA thioesterase
IXO1088_RS17445	COG1595	DNA-templated transcription, initiation
IXO1088_RS17460	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO1088_RS17500	COG1877	trehalose-phosphatase activity
IXO1088_RS17505	COG3387	PFAM Glycoside hydrolase 15-related
IXO1088_RS17530	COG0564	pseudouridine synthase activity
IXO1088_RS17535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO1088_RS17540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO1088_RS17540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO1088_RS17550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO1088_RS17555	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO1088_RS17595	COG2194	sulfuric ester hydrolase activity
IXO1088_RS17600	COG4969	Belongs to the N-Me-Phe pilin family
IXO1088_RS17610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO1088_RS17650	COG3209	COG3209 Rhs family protein
IXO1088_RS17665	COG3039	Transposase
IXO1088_RS17680	COG3039	Transposase
IXO1088_RS17715	COG1132	(ABC) transporter
IXO1088_RS17745	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS17750	COG5002	protein histidine kinase activity
IXO1088_RS17750	COG5000	phosphorelay sensor kinase activity
IXO1088_RS17755	COG0475	glutathione-regulated potassium exporter activity
IXO1088_RS17765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO1088_RS17785	COG1187	pseudouridine synthase activity
IXO1088_RS17790	COG5002	protein histidine kinase activity
IXO1088_RS17790	COG5001	Diguanylate cyclase
IXO1088_RS17910	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS17930	COG0415	Belongs to the DNA photolyase family
IXO1088_RS17935	COG0305	Participates in initiation and elongation during chromosome replication
IXO1088_RS17945	COG0367	asparagine synthase
IXO1088_RS17985	COG0084	hydrolase, TatD family'
IXO1088_RS17990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO1088_RS18050	COG0735	belongs to the Fur family
IXO1088_RS18055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO1088_RS18080	COG3039	Transposase
IXO1088_RS18125	COG2205	protein histidine kinase activity
IXO1088_RS18140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO1088_RS18150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO1088_RS18165	COG2198	Histidine kinase
IXO1088_RS18165	COG0643	Histidine kinase
IXO1088_RS18170	COG0840	transmembrane signaling receptor activity
IXO1088_RS18175	COG0835	chemotaxis
IXO1088_RS18180	COG2200	EAL domain
IXO1088_RS18180	COG2202	Pas domain
IXO1088_RS18180	COG2199	diguanylate cyclase activity
IXO1088_RS18185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO1088_RS18200	COG3590	peptidase
IXO1088_RS18215	COG0588	phosphoglycerate mutase activity
IXO1088_RS18220	COG1515	deoxyribonuclease V activity
IXO1088_RS18230	COG1741	Belongs to the pirin family
IXO1088_RS18265	COG3501	Rhs element vgr protein
IXO1088_RS18285	COG3501	Rhs element vgr protein
IXO1088_RS18290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO1088_RS18340	COG3501	Rhs element vgr protein
IXO1088_RS18425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO1088_RS18440	COG2197	response regulator
IXO1088_RS18445	COG4585	Histidine kinase
IXO1088_RS18465	COG2894	cell division
IXO1088_RS18470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO1088_RS18480	COG0642	Histidine kinase
IXO1088_RS18485	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS18490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO1088_RS18500	COG2194	sulfuric ester hydrolase activity
IXO1088_RS18530	COG3551	Protein conserved in bacteria
IXO1088_RS18590	COG0203	ribosomal protein L17
IXO1088_RS18600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO1088_RS18605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO1088_RS18615	COG0201	protein transport
IXO1088_RS18625	COG1841	ribosomal large subunit assembly
IXO1088_RS18655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO1088_RS18665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO1088_RS18670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO1088_RS18675	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO1088_RS18680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO1088_RS18690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO1088_RS18705	COG0089	rRNA binding
IXO1088_RS18710	COG0088	Forms part of the polypeptide exit tunnel
IXO1088_RS18715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO1088_RS18720	COG0051	transcription antitermination factor activity, RNA binding
IXO1088_RS18740	COG0049	tRNA binding
IXO1088_RS18745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO1088_RS18750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO1088_RS18755	COG0085	RNA polymerase activity
IXO1088_RS18760	COG0222	ribosome binding
IXO1088_RS18765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO1088_RS18775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO1088_RS18780	COG0250	Participates in transcription elongation, termination and antitermination
IXO1088_RS18785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO1088_RS18815	COG0012	GTP binding
IXO1088_RS18820	COG0193	aminoacyl-tRNA hydrolase activity
IXO1088_RS18830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO1088_RS18845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO1088_RS18855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO1088_RS18860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO1088_RS18870	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO1088_RS18890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO1088_RS18895	COG1295	ribonuclease BN
IXO1088_RS18925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO1088_RS18930	COG1404	Belongs to the peptidase S8 family
IXO1088_RS18935	COG1404	Belongs to the peptidase S8 family
IXO1088_RS18945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO1088_RS18970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO1088_RS18995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO1088_RS19010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO1088_RS19010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO1088_RS19050	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO1088_RS19060	COG3634	alkyl hydroperoxide reductase activity
IXO1088_RS19065	COG0583	DNA-binding transcription factor activity
IXO1088_RS19070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO1088_RS19075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO1088_RS19120	COG2197	response regulator
IXO1088_RS19230	COG3386	PFAM SMP-30 Gluconolaconase
IXO1088_RS19250	COG1024	Enoyl-CoA hydratase
IXO1088_RS19260	COG0318	PFAM AMP-dependent synthetase and ligase
IXO1088_RS19265	COG0583	DNA-binding transcription factor activity
IXO1088_RS19305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO1088_RS19310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO1088_RS19320	COG2096	Adenosyltransferase
IXO1088_RS19325	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO1088_RS19340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO1088_RS19350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO1088_RS19355	COG2967	ApaG domain
IXO1088_RS19360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IXO1088_RS19385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO1088_RS19405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO1088_RS19430	COG0642	Histidine kinase
IXO1088_RS19445	COG4181	ATPase activity
IXO1088_RS19455	COG2175	clavaminate synthase activity
IXO1088_RS19505	COG0667	Aldo Keto reductase
IXO1088_RS19515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO1088_RS19520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO1088_RS19530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO1088_RS19545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO1088_RS19580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO1088_RS19585	COG2226	methyltransferase
IXO1088_RS19630	COG3321	synthase
IXO1088_RS19630	COG0604	alcohol dehydrogenase
IXO1088_RS19630	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS19640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO1088_RS19655	COG0494	nUDIX hydrolase
IXO1088_RS19665	COG0653	protein targeting
IXO1088_RS19670	COG4942	peptidase
IXO1088_RS19670	COG1388	LysM domain
IXO1088_RS19680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO1088_RS19695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO1088_RS19700	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO1088_RS19705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO1088_RS19720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO1088_RS19725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO1088_RS19740	COG3116	cell division
IXO1088_RS19745	COG0275	rRNA processing
IXO1088_RS19780	COG0792	nuclease activity
IXO1088_RS19785	COG1988	membrane-bound metal-dependent
IXO1088_RS19790	COG0277	FAD linked oxidase domain protein
IXO1088_RS19795	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS19800	COG2205	protein histidine kinase activity
IXO1088_RS19810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO1088_RS19815	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO1088_RS19835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO1088_RS19840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO1088_RS19845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO1088_RS19865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO1088_RS19865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO1088_RS19885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO1088_RS19905	COG0488	(ABC) transporter
IXO1088_RS19950	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS19955	COG2205	protein histidine kinase activity
IXO1088_RS19990	COG2205	protein histidine kinase activity
IXO1088_RS20005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO1088_RS20130	COG1649	PFAM Uncharacterised BCR, COG1649
IXO1088_RS20130	COG0726	polysaccharide deacetylase
IXO1088_RS20135	COG1215	transferase activity, transferring glycosyl groups
IXO1088_RS20145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO1088_RS20150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO1088_RS20155	COG1609	Transcriptional regulator
IXO1088_RS20165	COG2188	Transcriptional regulator
IXO1088_RS20180	COG3250	beta-galactosidase activity
IXO1088_RS20230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO1088_RS20235	COG4191	Histidine kinase
IXO1088_RS20240	COG0784	Response regulator, receiver
IXO1088_RS20245	COG4251	negative regulation of phosphorylation
IXO1088_RS20250	COG2823	Periplasmic or secreted lipoprotein
IXO1088_RS20255	COG0673	inositol 2-dehydrogenase activity
IXO1088_RS20260	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO1088_RS20295	COG1056	cytidyltransferase-related domain
IXO1088_RS20295	COG1051	belongs to the nudix hydrolase family
IXO1088_RS20320	COG2921	Belongs to the UPF0250 family
IXO1088_RS20335	COG1686	Belongs to the peptidase S11 family
IXO1088_RS20340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO1088_RS20345	COG2951	lytic endotransglycosylase activity
IXO1088_RS20365	COG0772	Belongs to the SEDS family
IXO1088_RS20380	COG1792	Involved in formation and maintenance of cell shape
IXO1088_RS20385	COG1077	Cell shape determining protein MreB Mrl
IXO1088_RS20390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO1088_RS20435	COG2199	diguanylate cyclase activity
IXO1088_RS20440	COG0308	aminopeptidase N
IXO1088_RS20470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO1088_RS20515	COG1505	serine-type exopeptidase activity
IXO1088_RS20540	COG0181	hydroxymethylbilane synthase activity
IXO1088_RS20550	COG3275	phosphorelay sensor kinase activity
IXO1088_RS20595	COG0659	secondary active sulfate transmembrane transporter activity
IXO1088_RS20600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO1088_RS20600	COG5297	Belongs to the glycosyl hydrolase family 6
IXO1088_RS20610	COG0840	transmembrane signaling receptor activity
IXO1088_RS20665	COG3039	Transposase
IXO1088_RS20685	COG0598	Magnesium transport protein CorA
IXO1088_RS20695	COG1113	amino acid transport
IXO1088_RS20705	COG5297	Belongs to the glycosyl hydrolase family 6
IXO1088_RS20710	COG4305	rare lipoprotein A
IXO1088_RS20715	COG0697	spore germination
IXO1088_RS20770	COG4221	oxidoreductase activity
IXO1088_RS20800	COG0456	acetyltransferase
IXO1088_RS20810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO1088_RS20855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO1088_RS20855	COG2111	Na H antiporter
IXO1088_RS20860	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO1088_RS20865	COG0651	ATP synthesis coupled electron transport
IXO1088_RS20875	COG2212	antiporter activity
IXO1088_RS20880	COG1320	monovalent cation:proton antiporter activity
IXO1088_RS20890	COG3039	Transposase
IXO1088_RS20895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO1088_RS20915	COG3104	oligopeptide transport
IXO1088_RS20920	COG3483	tryptophan 2,3-dioxygenase activity
IXO1088_RS20930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO1088_RS20965	COG0183	Belongs to the thiolase family
IXO1088_RS21035	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO1088_RS21040	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO1088_RS21050	COG4948	Mandelate Racemase Muconate Lactonizing
IXO1088_RS21075	COG0531	amino acid
IXO1088_RS21100	COG4682	membrane
IXO1088_RS21105	COG2133	pyrroloquinoline quinone binding
IXO1088_RS21160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO1088_RS21165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO1088_RS21175	COG1610	YqeY-like protein
IXO1088_RS21195	COG1295	ribonuclease BN
IXO1088_RS21200	COG0358	DNA primase activity
IXO1088_RS21245	COG3039	Transposase
IXO1088_RS21375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO1088_RS21385	COG1560	Kdo2-lipid A biosynthetic process
IXO1088_RS21435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO1088_RS21435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO1088_RS21440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO1088_RS21445	COG0242	peptide deformylase activity
IXO1088_RS21450	COG1652	LysM domain
IXO1088_RS21455	COG0758	DNA mediated transformation
IXO1088_RS21460	COG2922	Belongs to the Smg family
IXO1088_RS21475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO1088_RS21475	COG1754	DNA topoisomerase type I activity
IXO1088_RS21480	COG0009	L-threonylcarbamoyladenylate synthase
IXO1088_RS21495	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS21505	COG0616	signal peptide processing
IXO1088_RS21510	COG0534	Mate efflux family protein
IXO1088_RS21530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO1088_RS21565	COG1324	tolerance protein
IXO1088_RS21575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO1088_RS21580	COG0511	ligase activity, forming carbon-carbon bonds
IXO1088_RS21590	COG0439	Biotin carboxylase
IXO1088_RS21635	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO1088_RS21700	COG3210	domain, Protein
IXO1088_RS21730	COG3210	domain, Protein
IXO1088_RS21735	COG2831	hemolysin activation secretion protein
IXO1088_RS21765	COG2267	carboxylic ester hydrolase activity
IXO1088_RS21770	COG2267	carboxylic ester hydrolase activity
IXO1088_RS21775	COG2267	carboxylic ester hydrolase activity
IXO1088_RS21790	COG0419	ATPase involved in DNA repair
IXO1088_RS21800	COG0151	Belongs to the GarS family
IXO1088_RS21820	COG1289	transmembrane transporter activity
IXO1088_RS21835	COG2814	Major facilitator Superfamily
IXO1088_RS21850	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO1088_RS21885	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS21930	COG0739	heme binding
IXO1088_RS21945	COG2211	Major facilitator Superfamily
IXO1088_RS21950	COG0708	Exodeoxyribonuclease III
IXO1088_RS21965	COG1192	Involved in chromosome partitioning
IXO1088_RS21970	COG1475	DNA binding
IXO1088_RS21985	COG0463	Glycosyl transferase, family 2
IXO1088_RS22010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO1088_RS22035	COG4221	oxidoreductase activity
IXO1088_RS22060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO1088_RS22065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO1088_RS22080	COG3485	protocatechuate 3,4-dioxygenase
IXO1088_RS22085	COG3485	protocatechuate 3,4-dioxygenase
IXO1088_RS22125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO1088_RS22130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO1088_RS22140	COG1042	CoA-binding domain protein
IXO1088_RS22140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO1088_RS22140	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO1088_RS22150	COG2239	Acts as a magnesium transporter
IXO1088_RS22165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO1088_RS22170	COG3387	PFAM Glycoside hydrolase 15-related
IXO1088_RS22185	COG3100	YcgL domain-containing protein
IXO1088_RS22190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO1088_RS22200	COG0463	Glycosyl transferase, family 2
IXO1088_RS22215	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS22225	COG0156	8-amino-7-oxononanoate synthase activity
IXO1088_RS22230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO1088_RS22235	COG1040	competence protein
IXO1088_RS22240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO1088_RS22250	COG0582	viral genome integration into host DNA
IXO1088_RS22305	COG0464	growth
IXO1088_RS22320	COG0628	permease
IXO1088_RS22330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO1088_RS22340	COG1595	DNA-templated transcription, initiation
IXO1088_RS22345	COG0753	catalase activity
IXO1088_RS22395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO1088_RS22400	COG0180	Tryptophanyl-tRNA synthetase
IXO1088_RS22405	COG3237	CsbD-like
IXO1088_RS22440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO1088_RS22455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO1088_RS22460	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO1088_RS22460	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO1088_RS22485	COG2205	protein histidine kinase activity
IXO1088_RS22490	COG0745	RESPONSE REGULATOR receiver
IXO1088_RS22500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO1088_RS22520	COG1566	PFAM secretion protein HlyD family protein
IXO1088_RS22535	COG1199	ATP-dependent helicase activity
IXO1088_RS22575	COG0583	DNA-binding transcription factor activity
IXO1088_RS22620	COG0625	glutathione transferase activity
IXO1088_RS22655	COG4555	ABC transporter
IXO1088_RS22665	COG1476	TRANSCRIPTIONal
IXO1088_RS22695	COG1131	(ABC) transporter
IXO1088_RS22700	COG0842	Transport permease protein
IXO1088_RS22795	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO1088_RS22805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO1088_RS22815	COG0564	pseudouridine synthase activity
IXO1088_RS22845	COG0339	signal peptide processing
IXO1088_RS22875	COG3254	rhamnose metabolic process
IXO1088_RS22880	COG0738	Major facilitator superfamily
IXO1088_RS22885	COG1414	Transcriptional regulator
IXO1088_RS22900	COG2205	protein histidine kinase activity
IXO1088_RS22910	COG3459	Glycosyltransferase 36 associated
IXO1088_RS22915	COG2211	Major facilitator Superfamily
IXO1088_RS22920	COG3265	gluconokinase activity
IXO1088_RS22925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO1088_RS22965	COG3039	Transposase
IXO1088_RS23025	COG1127	ABC transporter
IXO1088_RS23030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO1088_RS23035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO1088_RS23050	COG2853	Lipoprotein
IXO1088_RS23075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO1088_RS23140	COG0676	glucose-6-phosphate 1-epimerase activity
IXO1088_RS23165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO1088_RS23175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO1088_RS23185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO1088_RS23190	COG1064	alcohol dehydrogenase
IXO1088_RS23240	COG1522	sequence-specific DNA binding
IXO1088_RS23245	COG3186	Phenylalanine-4-hydroxylase
IXO1088_RS23285	COG0656	L-ascorbic acid biosynthetic process
IXO1088_RS23290	COG2130	NADP-dependent
IXO1088_RS23295	COG0667	Aldo Keto reductase
IXO1088_RS23305	COG1187	pseudouridine synthase activity
IXO1088_RS23315	COG1643	Atp-dependent helicase
IXO1088_RS23320	COG4807	Protein conserved in bacteria
IXO1088_RS23325	COG4948	Mandelate Racemase Muconate Lactonizing
IXO1088_RS23330	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO1088_RS23335	COG1028	Short-chain dehydrogenase reductase Sdr
IXO1088_RS23355	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO1088_RS23395	COG3162	membrane
IXO1088_RS23400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO1088_RS23415	COG0708	Exodeoxyribonuclease III
IXO1088_RS23430	COG2091	lysine biosynthetic process via aminoadipic acid
IXO1088_RS23440	COG3540	Alkaline phosphatase
IXO1088_RS23445	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO1088_RS23470	COG2159	amidohydrolase
IXO1088_RS23485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO1088_RS23490	COG0583	DNA-binding transcription factor activity
IXO1088_RS23495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO1088_RS23510	COG0210	DNA helicase
IXO1088_RS23530	COG0531	amino acid
IXO1088_RS23540	COG1322	Protein conserved in bacteria
IXO1088_RS23550	COG0386	Belongs to the glutathione peroxidase family
IXO1088_RS23600	COG0793	Belongs to the peptidase S41A family
IXO1088_RS23605	COG4942	peptidase
IXO1088_RS23615	COG2234	aminopeptidase activity
IXO1088_RS23670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO1088_RS23675	COG0302	gtp cyclohydrolase
IXO1088_RS23705	COG0477	Major facilitator Superfamily
IXO1088_RS23775	COG1192	Involved in chromosome partitioning
IXO1088_RS23805	COG1929	Belongs to the glycerate kinase type-1 family
IXO1088_RS23810	COG2271	Major facilitator Superfamily
IXO1088_RS23825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO1088_RS23830	COG0861	Integral membrane protein TerC family
IXO1088_RS23840	COG0584	glycerophosphoryl diester phosphodiesterase
IXO1088_RS23850	COG0671	phosphoesterase, PA-phosphatase related
IXO1088_RS23860	COG0726	polysaccharide deacetylase
IXO1088_RS23865	COG0706	membrane insertase activity