locus-tag	class	description
IXO134_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO134_RS00020	COG0187	DNA topoisomerase II activity
IXO134_RS00030	COG0501	Belongs to the peptidase M48B family
IXO134_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO134_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO134_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO134_RS00090	COG4772	TonB-dependent receptor
IXO134_RS00105	COG3039	Transposase
IXO134_RS00110	COG1304	FMN binding
IXO134_RS00130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO134_RS00140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_RS00215	COG3039	Transposase
IXO134_RS00235	COG2826	transposase and inactivated derivatives, IS30 family
IXO134_RS00260	COG3039	Transposase
IXO134_RS00270	COG1090	epimerase
IXO134_RS00290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO134_RS00400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO134_RS00475	COG1511	domain protein
IXO134_RS00475	COG3264	Mechanosensitive ion channel
IXO134_RS00490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO134_RS00495	COG2354	Protein conserved in bacteria
IXO134_RS00500	COG1649	PFAM Uncharacterised BCR, COG1649
IXO134_RS00520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO134_RS00545	COG0702	epimerase
IXO134_RS00560	COG1858	cytochrome C peroxidase
IXO134_RS00630	COG0513	Belongs to the DEAD box helicase family
IXO134_RS00635	COG3039	Transposase
IXO134_RS00685	COG1131	(ABC) transporter
IXO134_RS00720	COG1136	(ABC) transporter
IXO134_RS00760	COG1272	protein, Hemolysin III
IXO134_RS00765	COG1205	dead DEAH box helicase
IXO134_RS00765	COG1111	helicase
IXO134_RS00825	COG0069	glutamate synthase activity
IXO134_RS00825	COG0067	glutamate synthase
IXO134_RS00825	COG0070	glutamate synthase
IXO134_RS00830	COG0493	'glutamate synthase
IXO134_RS00875	COG1609	Transcriptional regulator
IXO134_RS00900	COG0366	Alpha amylase catalytic
IXO134_RS00905	COG0366	Alpha amylase catalytic
IXO134_RS00950	COG0606	chelatase, subunit chli
IXO134_RS00990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO134_RS00995	COG1166	arginine decarboxylase activity
IXO134_RS01055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO134_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS01105	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO134_RS01125	COG0210	DNA helicase
IXO134_RS01140	COG3132	Protein of unknown function, DUF480
IXO134_RS01145	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO134_RS01150	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO134_RS01185	COG2937	Belongs to the GPAT DAPAT family
IXO134_RS01225	COG3186	Phenylalanine-4-hydroxylase
IXO134_RS01230	COG1522	sequence-specific DNA binding
IXO134_RS01275	COG1064	alcohol dehydrogenase
IXO134_RS01280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_RS01290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_RS01300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_RS01320	COG0676	glucose-6-phosphate 1-epimerase activity
IXO134_RS01385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO134_RS01410	COG2853	Lipoprotein
IXO134_RS01425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO134_RS01430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO134_RS01435	COG1127	ABC transporter
IXO134_RS01510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_RS01520	COG3039	Transposase
IXO134_RS01525	COG3265	gluconokinase activity
IXO134_RS01530	COG2211	Major facilitator Superfamily
IXO134_RS01535	COG3459	Glycosyltransferase 36 associated
IXO134_RS01545	COG2205	protein histidine kinase activity
IXO134_RS01555	COG1414	Transcriptional regulator
IXO134_RS01560	COG0738	Major facilitator superfamily
IXO134_RS01565	COG3254	rhamnose metabolic process
IXO134_RS01600	COG0339	signal peptide processing
IXO134_RS01630	COG0564	pseudouridine synthase activity
IXO134_RS01640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO134_RS01650	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO134_RS01715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO134_RS01725	COG0842	Transport permease protein
IXO134_RS01730	COG1131	(ABC) transporter
IXO134_RS01760	COG1476	TRANSCRIPTIONal
IXO134_RS01770	COG4555	ABC transporter
IXO134_RS01810	COG0625	glutathione transferase activity
IXO134_RS01855	COG0583	DNA-binding transcription factor activity
IXO134_RS01895	COG1199	ATP-dependent helicase activity
IXO134_RS01930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO134_RS01960	COG3228	Belongs to the MtfA family
IXO134_RS01970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO134_RS01970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO134_RS01975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO134_RS01990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO134_RS02025	COG3237	CsbD-like
IXO134_RS02030	COG0180	Tryptophanyl-tRNA synthetase
IXO134_RS02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO134_RS02080	COG0753	catalase activity
IXO134_RS02095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO134_RS02105	COG0628	permease
IXO134_RS02115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO134_RS02120	COG1040	competence protein
IXO134_RS02125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO134_RS02130	COG0156	8-amino-7-oxononanoate synthase activity
IXO134_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS02155	COG0463	Glycosyl transferase, family 2
IXO134_RS02165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO134_RS02170	COG3100	YcgL domain-containing protein
IXO134_RS02185	COG3387	PFAM Glycoside hydrolase 15-related
IXO134_RS02190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO134_RS02205	COG2239	Acts as a magnesium transporter
IXO134_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO134_RS02220	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO134_RS02220	COG1042	CoA-binding domain protein
IXO134_RS02230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO134_RS02235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO134_RS02270	COG3485	protocatechuate 3,4-dioxygenase
IXO134_RS02290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO134_RS02295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO134_RS02320	COG4221	oxidoreductase activity
IXO134_RS02345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO134_RS02370	COG0463	Glycosyl transferase, family 2
IXO134_RS02385	COG1475	DNA binding
IXO134_RS02390	COG1192	Involved in chromosome partitioning
IXO134_RS02405	COG0708	Exodeoxyribonuclease III
IXO134_RS02410	COG2211	Major facilitator Superfamily
IXO134_RS02425	COG0739	heme binding
IXO134_RS02470	COG0745	RESPONSE REGULATOR receiver
IXO134_RS02505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO134_RS02520	COG2814	Major facilitator Superfamily
IXO134_RS02535	COG1289	transmembrane transporter activity
IXO134_RS02555	COG1136	(ABC) transporter
IXO134_RS02555	COG0577	efflux transmembrane transporter activity
IXO134_RS02560	COG0151	Belongs to the GarS family
IXO134_RS02570	COG0138	bifunctional purine biosynthesis protein purh
IXO134_RS02600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO134_RS02640	COG0439	Biotin carboxylase
IXO134_RS02650	COG0511	ligase activity, forming carbon-carbon bonds
IXO134_RS02655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO134_RS02665	COG1324	tolerance protein
IXO134_RS02700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO134_RS02720	COG0534	Mate efflux family protein
IXO134_RS02725	COG0616	signal peptide processing
IXO134_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS02750	COG0009	L-threonylcarbamoyladenylate synthase
IXO134_RS02755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO134_RS02755	COG1754	DNA topoisomerase type I activity
IXO134_RS02770	COG2922	Belongs to the Smg family
IXO134_RS02775	COG0758	DNA mediated transformation
IXO134_RS02780	COG1652	LysM domain
IXO134_RS02785	COG0242	peptide deformylase activity
IXO134_RS02790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO134_RS02795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO134_RS02795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO134_RS02845	COG1560	Kdo2-lipid A biosynthetic process
IXO134_RS02855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO134_RS03005	COG3039	Transposase
IXO134_RS03015	COG1271	oxidase subunit
IXO134_RS03080	COG0531	amino acid
IXO134_RS03100	COG3590	peptidase
IXO134_RS03110	COG0667	Aldo Keto reductase
IXO134_RS03125	COG3384	dioxygenase
IXO134_RS03135	COG1573	uracil-dna glycosylase
IXO134_RS03145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO134_RS03155	COG0025	NhaP-type Na H and K H
IXO134_RS03160	COG1131	(ABC) transporter
IXO134_RS03165	COG0842	Transport permease protein
IXO134_RS03180	COG1404	Belongs to the peptidase S8 family
IXO134_RS03195	COG0745	RESPONSE REGULATOR receiver
IXO134_RS03245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_RS03270	COG2202	Pas domain
IXO134_RS03270	COG2205	protein histidine kinase activity
IXO134_RS03300	COG2813	Specifically methylates the guanine in position
IXO134_RS03305	COG1187	pseudouridine synthase activity
IXO134_RS03310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO134_RS03345	COG0697	spore germination
IXO134_RS03355	COG2011	ABC-type metal ion transport system permease component
IXO134_RS03385	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO134_RS03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO134_RS03415	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO134_RS03425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO134_RS03435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO134_RS03440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO134_RS03445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO134_RS03450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO134_RS03500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_RS03505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO134_RS03555	COG0339	signal peptide processing
IXO134_RS03590	COG1956	GAF domain-containing protein
IXO134_RS03595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO134_RS03605	COG0720	synthase
IXO134_RS03610	COG0513	Belongs to the DEAD box helicase family
IXO134_RS03620	COG0625	glutathione transferase activity
IXO134_RS03650	COG0626	cystathionine gamma-synthase activity
IXO134_RS03690	COG3328	transposase activity
IXO134_RS03715	COG2086	electron transfer activity
IXO134_RS03740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO134_RS03740	COG0662	Cupin 2, conserved barrel domain protein
IXO134_RS03745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO134_RS03780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO134_RS03780	COG3218	ABC-type transport auxiliary lipoprotein component
IXO134_RS03785	COG1127	ABC transporter
IXO134_RS03790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO134_RS03810	COG0442	prolyl-tRNA aminoacylation
IXO134_RS03820	COG1183	phosphatidylcholine synthase activity
IXO134_RS03850	COG3039	Transposase
IXO134_RS03885	COG3039	Transposase
IXO134_RS03915	COG0525	valine-tRNA ligase activity
IXO134_RS03930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO134_RS03940	COG0795	lipopolysaccharide-transporting ATPase activity
IXO134_RS03955	COG4974	Belongs to the 'phage' integrase family
IXO134_RS03960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO134_RS03965	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO134_RS03965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO134_RS03970	COG5295	Hep Hag repeat protein
IXO134_RS03980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO134_RS03990	COG1459	type II secretion system
IXO134_RS03995	COG2165	general secretion pathway protein
IXO134_RS04000	COG4970	Tfp pilus assembly protein FimT
IXO134_RS04005	COG2165	general secretion pathway protein
IXO134_RS04010	COG4795	General secretion pathway protein
IXO134_RS04015	COG3156	type II secretion system protein K
IXO134_RS04020	COG3166	PFAM Fimbrial assembly family protein
IXO134_RS04035	COG1450	Type ii and iii secretion system protein
IXO134_RS04050	COG2188	Transcriptional regulator
IXO134_RS04095	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO134_RS04100	COG1518	maintenance of DNA repeat elements
IXO134_RS04135	COG3039	Transposase
IXO134_RS04150	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO134_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS04180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO134_RS04190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO134_RS04195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO134_RS04230	COG3829	transcription factor binding
IXO134_RS04310	COG2826	transposase and inactivated derivatives, IS30 family
IXO134_RS04320	COG0678	peroxiredoxin activity
IXO134_RS04340	COG0330	HflC and HflK could
IXO134_RS04345	COG0330	HflC and HflK could
IXO134_RS04355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO134_RS04360	COG0308	aminopeptidase N
IXO134_RS04420	COG1560	Kdo2-lipid A biosynthetic process
IXO134_RS04425	COG1519	Transferase
IXO134_RS04430	COG1538	Outer membrane efflux protein
IXO134_RS04435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO134_RS04465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO134_RS04470	COG0066	3-isopropylmalate dehydratase activity
IXO134_RS04475	COG2226	methyltransferase
IXO134_RS04505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO134_RS04515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO134_RS04520	COG3710	Transcriptional regulator
IXO134_RS04545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO134_RS04565	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO134_RS04600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO134_RS04610	COG3781	membrane
IXO134_RS04750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO134_RS04770	COG1217	gtp-binding protein TYPA
IXO134_RS04775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO134_RS04780	COG0039	L-malate dehydrogenase activity
IXO134_RS04785	COG0625	glutathione transferase activity
IXO134_RS04800	COG3039	Transposase
IXO134_RS04825	COG0584	glycerophosphoryl diester phosphodiesterase
IXO134_RS04860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO134_RS04895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO134_RS04900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO134_RS04905	COG0583	DNA-binding transcription factor activity
IXO134_RS04910	COG3634	alkyl hydroperoxide reductase activity
IXO134_RS04920	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO134_RS04960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO134_RS04960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO134_RS04975	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO134_RS05000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO134_RS05025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO134_RS05035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO134_RS05065	COG1295	ribonuclease BN
IXO134_RS05070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO134_RS05090	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO134_RS05100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO134_RS05105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO134_RS05115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO134_RS05130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO134_RS05140	COG0193	aminoacyl-tRNA hydrolase activity
IXO134_RS05145	COG0012	GTP binding
IXO134_RS05175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO134_RS05180	COG0250	Participates in transcription elongation, termination and antitermination
IXO134_RS05185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO134_RS05195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO134_RS05200	COG0222	ribosome binding
IXO134_RS05205	COG0085	RNA polymerase activity
IXO134_RS05210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO134_RS05215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO134_RS05220	COG0049	tRNA binding
IXO134_RS05240	COG0051	transcription antitermination factor activity, RNA binding
IXO134_RS05245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO134_RS05250	COG0088	Forms part of the polypeptide exit tunnel
IXO134_RS05255	COG0089	rRNA binding
IXO134_RS05270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO134_RS05280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO134_RS05285	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO134_RS05290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO134_RS05295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO134_RS05305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO134_RS05335	COG1841	ribosomal large subunit assembly
IXO134_RS05345	COG0201	protein transport
IXO134_RS05355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO134_RS05360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO134_RS05370	COG0203	ribosomal protein L17
IXO134_RS05430	COG3551	Protein conserved in bacteria
IXO134_RS05460	COG2194	sulfuric ester hydrolase activity
IXO134_RS05470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO134_RS05475	COG0745	RESPONSE REGULATOR receiver
IXO134_RS05480	COG0642	Histidine kinase
IXO134_RS05490	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO134_RS05495	COG2894	cell division
IXO134_RS05510	COG4585	Histidine kinase
IXO134_RS05515	COG2197	response regulator
IXO134_RS05530	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO134_RS05555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO134_RS05670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_RS05680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_RS05690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_RS05735	COG3328	transposase activity
IXO134_RS05750	COG3179	chitinase
IXO134_RS05865	COG3039	Transposase
IXO134_RS05880	COG3039	Transposase
IXO134_RS05940	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO134_RS05960	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO134_RS05965	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO134_RS05970	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO134_RS05985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO134_RS06060	COG0587	DNA-directed DNA polymerase activity
IXO134_RS06075	COG1297	OPT oligopeptide transporter protein
IXO134_RS06095	COG1506	peptidase
IXO134_RS06095	COG0823	Involved in the tonB-independent uptake of proteins
IXO134_RS06115	COG2207	Transcriptional regulator
IXO134_RS06115	COG1917	Cupin 2, conserved barrel domain protein
IXO134_RS06140	COG0753	catalase activity
IXO134_RS06180	COG0469	pyruvate kinase activity
IXO134_RS06185	COG3588	fructose-bisphosphate aldolase
IXO134_RS06190	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO134_RS06240	COG0784	Response regulator, receiver
IXO134_RS06240	COG2198	Histidine kinase
IXO134_RS06240	COG2205	protein histidine kinase activity
IXO134_RS06260	COG0175	sulfate reduction
IXO134_RS06265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO134_RS06270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO134_RS06275	COG0175	sulfate reduction
IXO134_RS06280	COG0529	Catalyzes the synthesis of activated sulfate
IXO134_RS06280	COG2895	sulfate adenylyltransferase (ATP) activity
IXO134_RS06290	COG3039	Transposase
IXO134_RS06300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO134_RS06305	COG0308	aminopeptidase N
IXO134_RS06325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO134_RS06345	COG1970	mechanosensitive ion channel activity
IXO134_RS06375	COG0471	metal ion transport
IXO134_RS06375	COG3273	potassium ion transport
IXO134_RS06385	COG2022	thiamine diphosphate biosynthetic process
IXO134_RS06500	COG3118	belongs to the thioredoxin family
IXO134_RS06525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO134_RS06545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO134_RS06575	COG2968	Membrane
IXO134_RS06590	COG3164	Protein of unknown function
IXO134_RS06600	COG0312	modulator of DNA gyrase
IXO134_RS06605	COG3028	Belongs to the UPF0307 family
IXO134_RS06610	COG0312	modulator of DNA gyrase
IXO134_RS06635	COG0142	geranyltranstransferase activity
IXO134_RS06640	COG1722	exodeoxyribonuclease VII activity
IXO134_RS06645	COG0037	tRNA processing
IXO134_RS06650	COG1785	Belongs to the alkaline phosphatase family
IXO134_RS06670	COG0791	NLP P60 protein
IXO134_RS06675	COG0791	NLP P60 protein
IXO134_RS06680	COG1047	Peptidyl-prolyl cis-trans
IXO134_RS06685	COG2311	Membrane
IXO134_RS06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_RS06730	COG0489	protein tyrosine kinase activity
IXO134_RS06735	COG0717	Belongs to the dCTP deaminase family
IXO134_RS06765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO134_RS06805	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO134_RS06810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO134_RS06815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO134_RS06820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO134_RS06840	COG0101	tRNA pseudouridine synthase activity
IXO134_RS06845	COG0135	phosphoribosylanthranilate isomerase activity
IXO134_RS06865	COG0159	tryptophan synthase activity
IXO134_RS06870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO134_RS06875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO134_RS06925	COG0149	triose-phosphate isomerase activity
IXO134_RS06940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO134_RS06950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO134_RS06955	COG0649	NAD binding
IXO134_RS06960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO134_RS06965	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO134_RS06970	COG1034	ATP synthesis coupled electron transport
IXO134_RS06975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO134_RS07005	COG1007	ATP synthesis coupled electron transport
IXO134_RS07015	COG0779	Required for maturation of 30S ribosomal subunits
IXO134_RS07020	COG0195	Participates in both transcription termination and antitermination
IXO134_RS07025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO134_RS07040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO134_RS07045	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO134_RS07080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO134_RS07090	COG2095	MarC family integral membrane protein
IXO134_RS07105	COG1611	Belongs to the LOG family
IXO134_RS07140	COG3039	Transposase
IXO134_RS07320	COG3179	chitinase
IXO134_RS07365	COG4695	Portal protein
IXO134_RS07385	COG0758	DNA mediated transformation
IXO134_RS07385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IXO134_RS07415	COG4969	Belongs to the N-Me-Phe pilin family
IXO134_RS07420	COG0556	nucleotide-excision repair
IXO134_RS07460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO134_RS07475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO134_RS07530	COG0438	transferase activity, transferring glycosyl groups
IXO134_RS07535	COG0438	transferase activity, transferring glycosyl groups
IXO134_RS07545	COG0438	transferase activity, transferring glycosyl groups
IXO134_RS07585	COG3040	lipid binding
IXO134_RS07660	COG4191	Histidine kinase
IXO134_RS07660	COG0784	Response regulator, receiver
IXO134_RS07680	COG0552	protein localization to endoplasmic reticulum
IXO134_RS07690	COG3938	Belongs to the proline racemase family
IXO134_RS07695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_RS07710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO134_RS07720	COG0006	proline dipeptidase activity
IXO134_RS07735	COG0531	amino acid
IXO134_RS07765	COG4206	TonB-dependent receptor
IXO134_RS07790	COG3328	transposase activity
IXO134_RS07850	COG0746	molybdenum cofactor guanylyltransferase activity
IXO134_RS07875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO134_RS07875	COG1648	precorrin-2 dehydrogenase activity
IXO134_RS07905	COG3039	Transposase
IXO134_RS07910	COG3039	Transposase
IXO134_RS07940	COG3039	Transposase
IXO134_RS07955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO134_RS07975	COG1054	Belongs to the UPF0176 family
IXO134_RS07990	COG1530	ribonuclease E activity
IXO134_RS08000	COG3064	Membrane
IXO134_RS08015	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO134_RS08065	COG3039	Transposase
IXO134_RS08190	COG0631	protein serine/threonine phosphatase activity
IXO134_RS08195	COG0515	serine threonine protein kinase
IXO134_RS08225	COG1858	cytochrome C peroxidase
IXO134_RS08285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_RS08310	COG2201	protein-glutamate methylesterase activity
IXO134_RS08355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO134_RS08375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO134_RS08390	COG1595	DNA-templated transcription, initiation
IXO134_RS08440	COG2244	polysaccharide biosynthetic process
IXO134_RS08470	COG2264	protein methyltransferase activity
IXO134_RS08480	COG0438	transferase activity, transferring glycosyl groups
IXO134_RS08495	COG1136	(ABC) transporter
IXO134_RS08500	COG1132	(ABC) transporter
IXO134_RS08510	COG0477	Major facilitator Superfamily
IXO134_RS08520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO134_RS08535	COG1253	flavin adenine dinucleotide binding
IXO134_RS08545	COG0306	phosphate transporter
IXO134_RS08575	COG0504	CTP synthase activity
IXO134_RS08580	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO134_RS08590	COG0148	phosphopyruvate hydratase activity
IXO134_RS08595	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO134_RS08600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO134_RS08610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO134_RS08620	COG2840	Smr protein MutS2
IXO134_RS08625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO134_RS08630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO134_RS08635	COG1238	metal cluster binding
IXO134_RS08650	COG1534	Rna-binding protein
IXO134_RS08655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO134_RS08665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO134_RS08680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO134_RS08685	COG1546	Belongs to the CinA family
IXO134_RS08700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO134_RS08705	COG2137	regulation of response to DNA damage stimulus
IXO134_RS08710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO134_RS08715	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO134_RS08740	COG0305	Participates in initiation and elongation during chromosome replication
IXO134_RS08745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO134_RS08770	COG1741	Belongs to the pirin family
IXO134_RS08775	COG0583	DNA-binding transcription factor activity
IXO134_RS08800	COG0351	phosphomethylpyrimidine kinase
IXO134_RS08810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO134_RS08815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO134_RS08835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO134_RS08845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO134_RS08850	COG3734	2-keto-3-deoxy-galactonokinase
IXO134_RS08860	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_RS08865	COG0800	Aldolase
IXO134_RS08880	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO134_RS08890	COG1070	Carbohydrate kinase
IXO134_RS08900	COG0477	Major facilitator Superfamily
IXO134_RS08920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO134_RS08965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO134_RS08970	COG2258	MOSC domain
IXO134_RS08980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO134_RS08985	COG0505	Belongs to the CarA family
IXO134_RS08995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO134_RS09000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO134_RS09010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO134_RS09070	COG2198	Histidine kinase
IXO134_RS09070	COG0784	Response regulator, receiver
IXO134_RS09070	COG2205	protein histidine kinase activity
IXO134_RS09075	COG1024	Enoyl-CoA hydratase
IXO134_RS09080	COG0318	PFAM AMP-dependent synthetase and ligase
IXO134_RS09110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO134_RS09140	COG0840	transmembrane signaling receptor activity
IXO134_RS09160	COG3039	Transposase
IXO134_RS09175	COG0835	chemotaxis
IXO134_RS09190	COG0840	transmembrane signaling receptor activity
IXO134_RS09195	COG0840	transmembrane signaling receptor activity
IXO134_RS09200	COG0840	transmembrane signaling receptor activity
IXO134_RS09205	COG0840	transmembrane signaling receptor activity
IXO134_RS09215	COG0840	transmembrane signaling receptor activity
IXO134_RS09225	COG0840	transmembrane signaling receptor activity
IXO134_RS09255	COG0745	RESPONSE REGULATOR receiver
IXO134_RS09265	COG0835	chemotaxis
IXO134_RS09280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO134_RS09300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO134_RS09310	COG4771	TonB-dependent receptor
IXO134_RS09345	COG3039	Transposase
IXO134_RS09415	COG3501	Rhs element vgr protein
IXO134_RS09415	COG3409	Peptidoglycan-binding domain 1 protein
IXO134_RS09435	COG3409	Peptidoglycan-binding domain 1 protein
IXO134_RS09435	COG3501	Rhs element vgr protein
IXO134_RS09455	COG3409	Peptidoglycan-binding domain 1 protein
IXO134_RS09455	COG3501	Rhs element vgr protein
IXO134_RS09500	COG3039	Transposase
IXO134_RS09505	COG3039	Transposase
IXO134_RS09520	COG3039	Transposase
IXO134_RS09550	COG3039	Transposase
IXO134_RS09560	COG3039	Transposase
IXO134_RS09570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO134_RS09570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO134_RS09575	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO134_RS09580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO134_RS09580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO134_RS09585	COG1609	Transcriptional regulator
IXO134_RS09610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO134_RS09615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_RS09625	COG2902	Dehydrogenase
IXO134_RS09630	COG3039	Transposase
IXO134_RS09640	COG5002	protein histidine kinase activity
IXO134_RS09640	COG2205	protein histidine kinase activity
IXO134_RS09640	COG0784	Response regulator, receiver
IXO134_RS09645	COG2733	membrane
IXO134_RS09655	COG1121	(ABC) transporter
IXO134_RS09660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO134_RS09665	COG2223	nitrite transmembrane transporter activity
IXO134_RS09675	COG0243	molybdopterin cofactor binding
IXO134_RS09685	COG0477	Major facilitator Superfamily
IXO134_RS09695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_RS09700	COG0174	glutamine synthetase
IXO134_RS09735	COG3842	ATPase activity
IXO134_RS09755	COG1012	belongs to the aldehyde dehydrogenase family
IXO134_RS09770	COG4535	Mg2 and Co2 transporter CorC
IXO134_RS09790	COG1702	phosphate starvation-inducible protein PhoH
IXO134_RS09815	COG0741	lytic transglycosylase activity
IXO134_RS09820	COG0723	plastoquinol--plastocyanin reductase activity
IXO134_RS09825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO134_RS09830	COG2857	Cytochrome c1
IXO134_RS09835	COG0625	glutathione transferase activity
IXO134_RS09840	COG2969	positive regulation of protein catabolic process
IXO134_RS09865	COG2094	Belongs to the DNA glycosylase MPG family
IXO134_RS09875	COG3328	transposase activity
IXO134_RS09880	COG3039	Transposase
IXO134_RS09955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_RS09975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO134_RS09980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO134_RS09980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO134_RS09985	COG0802	atpase or kinase
IXO134_RS09990	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO134_RS09995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO134_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS10025	COG0501	Belongs to the peptidase M48B family
IXO134_RS10035	COG2081	HI0933 family
IXO134_RS10040	COG4681	YaeQ
IXO134_RS10045	COG1671	Belongs to the UPF0178 family
IXO134_RS10055	COG0625	glutathione transferase activity
IXO134_RS10065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO134_RS10070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO134_RS10075	COG0513	Belongs to the DEAD box helicase family
IXO134_RS10080	COG0488	(ABC) transporter
IXO134_RS10100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO134_RS10105	COG0483	inositol monophosphate 1-phosphatase activity
IXO134_RS10120	COG3300	MHYT domain
IXO134_RS10120	COG5001	Diguanylate cyclase
IXO134_RS10125	COG1509	lysine 2,3-aminomutase activity
IXO134_RS10140	COG0402	S-adenosylhomocysteine deaminase activity
IXO134_RS10145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO134_RS10170	COG4677	pectinesterase activity
IXO134_RS10195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO134_RS10225	COG2166	iron-sulfur cluster assembly
IXO134_RS10240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO134_RS10245	COG0137	argininosuccinate synthase activity
IXO134_RS10255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO134_RS10260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO134_RS10275	COG0165	Argininosuccinate lyase
IXO134_RS10295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO134_RS10330	COG3039	Transposase
IXO134_RS10345	COG4988	ABC transporter
IXO134_RS10350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO134_RS10360	COG3039	Transposase
IXO134_RS10455	COG3039	Transposase
IXO134_RS10470	COG3209	COG3209 Rhs family protein
IXO134_RS10480	COG3039	Transposase
IXO134_RS10515	COG0784	Response regulator, receiver
IXO134_RS10515	COG2198	Histidine kinase
IXO134_RS10515	COG0643	Histidine kinase
IXO134_RS10570	COG1684	flagellar biosynthetic protein fliR
IXO134_RS10585	COG3190	flagellar
IXO134_RS10635	COG1677	Flagellar hook-basal body complex protein FliE
IXO134_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS10675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO134_RS10695	COG2201	protein-glutamate methylesterase activity
IXO134_RS10730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO134_RS10735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO134_RS10770	COG4787	bacterial-type flagellum-dependent cell motility
IXO134_RS10780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO134_RS10785	COG1558	bacterial-type flagellum-dependent cell motility
IXO134_RS10795	COG0784	Response regulator, receiver
IXO134_RS10795	COG0835	chemotaxis
IXO134_RS10815	COG5002	protein histidine kinase activity
IXO134_RS10825	COG4585	Histidine kinase
IXO134_RS10830	COG5001	Diguanylate cyclase
IXO134_RS10855	COG0482	sulfurtransferase activity
IXO134_RS10870	COG0542	response to heat
IXO134_RS10905	COG0492	ferredoxin-NADP+ reductase activity
IXO134_RS10910	COG1674	ftsk spoiiie
IXO134_RS10930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO134_RS10950	COG0038	chloride channel
IXO134_RS10955	COG0183	Belongs to the thiolase family
IXO134_RS10960	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO134_RS10960	COG1024	Enoyl-CoA hydratase
IXO134_RS10975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO134_RS10985	COG1426	Protein conserved in bacteria
IXO134_RS10995	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_RS11005	COG0303	'Molybdopterin
IXO134_RS11060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO134_RS11110	COG0742	ribosomal rna small subunit methyltransferase
IXO134_RS11115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO134_RS11130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO134_RS11135	COG0405	Gamma-glutamyltransferase
IXO134_RS11160	COG3039	Transposase
IXO134_RS11230	COG0343	queuine tRNA-ribosyltransferase activity
IXO134_RS11235	COG1862	Preprotein translocase
IXO134_RS11240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO134_RS11245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO134_RS11255	COG3039	Transposase
IXO134_RS11285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO134_RS11295	COG0704	Plays a role in the regulation of phosphate uptake
IXO134_RS11310	COG0573	inorganic phosphate transmembrane transporter activity
IXO134_RS11315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO134_RS11365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO134_RS11375	COG1024	Enoyl-CoA hydratase
IXO134_RS11390	COG0494	nUDIX hydrolase
IXO134_RS11435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO134_RS11435	COG0116	Belongs to the methyltransferase superfamily
IXO134_RS11460	COG0667	Aldo Keto reductase
IXO134_RS11470	COG2925	Exonuclease
IXO134_RS11495	COG0288	reversible hydration of carbon dioxide
IXO134_RS11525	COG0316	Belongs to the HesB IscA family
IXO134_RS11530	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO134_RS11540	COG0359	binds to the 23S rRNA
IXO134_RS11550	COG3115	cell septum assembly
IXO134_RS11570	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO134_RS11590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO134_RS11615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO134_RS11625	COG2986	histidine ammonia-lyase
IXO134_RS11630	COG1228	amidohydrolase
IXO134_RS11670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO134_RS11680	COG0077	Prephenate dehydratase
IXO134_RS11680	COG1605	Chorismate mutase
IXO134_RS11685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO134_RS11715	COG4566	intracellular signal transduction
IXO134_RS11760	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO134_RS11765	COG1469	GTP cyclohydrolase I activity
IXO134_RS11775	COG0617	tRNA 3'-terminal CCA addition
IXO134_RS11785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO134_RS11790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO134_RS11820	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO134_RS11835	COG2203	Gaf domain
IXO134_RS11835	COG3706	GGDEF domain
IXO134_RS11835	COG4251	negative regulation of phosphorylation
IXO134_RS11835	COG5001	Diguanylate cyclase
IXO134_RS11895	COG1595	DNA-templated transcription, initiation
IXO134_RS11920	COG0386	Belongs to the glutathione peroxidase family
IXO134_RS11995	COG3039	Transposase
IXO134_RS12010	COG5002	protein histidine kinase activity
IXO134_RS12010	COG0784	Response regulator, receiver
IXO134_RS12010	COG2205	protein histidine kinase activity
IXO134_RS12050	COG0800	Aldolase
IXO134_RS12055	COG0129	dihydroxy-acid dehydratase activity
IXO134_RS12060	COG0363	glucosamine-6-phosphate deaminase activity
IXO134_RS12070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO134_RS12085	COG0354	folic acid binding
IXO134_RS12100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO134_RS12115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO134_RS12130	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO134_RS12155	COG0811	peptide transport
IXO134_RS12170	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO134_RS12180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO134_RS12190	COG0322	excinuclease ABC activity
IXO134_RS12225	COG3328	transposase activity
IXO134_RS12245	COG3039	Transposase
IXO134_RS12595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO134_RS12595	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO134_RS12605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO134_RS12615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO134_RS12615	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO134_RS12630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO134_RS12650	COG0124	histidyl-tRNA synthetase
IXO134_RS12665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO134_RS12700	COG1012	belongs to the aldehyde dehydrogenase family
IXO134_RS12720	COG0167	dihydroorotate dehydrogenase activity
IXO134_RS12725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO134_RS12730	COG0697	spore germination
IXO134_RS12755	COG0671	phosphoesterase, PA-phosphatase related
IXO134_RS12770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO134_RS12785	COG2183	response to ionizing radiation
IXO134_RS12795	COG0723	plastoquinol--plastocyanin reductase activity
IXO134_RS12795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_RS12810	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO134_RS12820	COG1183	phosphatidylcholine synthase activity
IXO134_RS12825	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS12850	COG0668	transmembrane transport
IXO134_RS12870	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO134_RS12905	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS12920	COG0583	DNA-binding transcription factor activity
IXO134_RS12925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO134_RS12930	COG3002	Belongs to the UPF0753 family
IXO134_RS12945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO134_RS12965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO134_RS12975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO134_RS12980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO134_RS12990	COG0776	regulation of translation
IXO134_RS12995	COG0539	negative regulation of cytoplasmic translation
IXO134_RS13000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO134_RS13015	COG2957	Belongs to the agmatine deiminase family
IXO134_RS13025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO134_RS13050	COG0395	ABC-type sugar transport system, permease component
IXO134_RS13055	COG1175	transmembrane transport
IXO134_RS13085	COG2350	Protein conserved in bacteria
IXO134_RS13090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO134_RS13095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO134_RS13100	COG1187	pseudouridine synthase activity
IXO134_RS13125	COG0436	Aminotransferase
IXO134_RS13190	COG0277	FAD linked oxidase domain protein
IXO134_RS13195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO134_RS13205	COG0531	amino acid
IXO134_RS13210	COG0531	amino acid
IXO134_RS13215	COG0235	Class ii aldolase
IXO134_RS13220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO134_RS13250	COG2201	protein-glutamate methylesterase activity
IXO134_RS13295	COG0583	DNA-binding transcription factor activity
IXO134_RS13305	COG3039	Transposase
IXO134_RS13405	COG3039	Transposase
IXO134_RS13415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO134_RS13435	COG0557	exoribonuclease II activity
IXO134_RS13460	COG1960	acyl-CoA dehydrogenase activity
IXO134_RS13465	COG2226	methyltransferase
IXO134_RS13470	COG0646	methionine synthase
IXO134_RS13470	COG1410	methionine synthase
IXO134_RS13475	COG0646	methionine synthase
IXO134_RS13475	COG1410	methionine synthase
IXO134_RS13485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_RS13495	COG1609	Transcriptional regulator
IXO134_RS13510	COG2900	Belongs to the SlyX family
IXO134_RS13525	COG0386	Belongs to the glutathione peroxidase family
IXO134_RS13535	COG1725	Transcriptional regulator
IXO134_RS13540	COG1131	(ABC) transporter
IXO134_RS13600	COG2850	peptidyl-arginine hydroxylation
IXO134_RS13635	COG1132	(ABC) transporter
IXO134_RS13660	COG0287	Prephenate dehydrogenase
IXO134_RS13660	COG1605	Chorismate mutase
IXO134_RS13665	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO134_RS13670	COG0484	heat shock protein binding
IXO134_RS13675	COG0443	Heat shock 70 kDa protein
IXO134_RS13680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO134_RS13690	COG0497	DNA recombination
IXO134_RS13700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_RS13705	COG2914	Belongs to the UPF0125 (RnfH) family
IXO134_RS13715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO134_RS13730	COG1960	acyl-CoA dehydrogenase activity
IXO134_RS13740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO134_RS13795	COG2814	Major facilitator Superfamily
IXO134_RS13800	COG1566	PFAM secretion protein HlyD family protein
IXO134_RS13815	COG2207	Transcriptional regulator
IXO134_RS13840	COG4774	siderophore transport
IXO134_RS13850	COG0367	asparagine synthase
IXO134_RS13865	COG1393	Belongs to the ArsC family
IXO134_RS13880	COG3039	Transposase
IXO134_RS13930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO134_RS13945	COG0233	cytoplasmic translational termination
IXO134_RS13955	COG0575	Belongs to the CDS family
IXO134_RS13965	COG0750	zinc metalloprotease
IXO134_RS13985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO134_RS13990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO134_RS14010	COG0825	malonyl-CoA metabolic process
IXO134_RS14020	COG4771	TonB-dependent receptor
IXO134_RS14025	COG1131	(ABC) transporter
IXO134_RS14050	COG1981	membrane
IXO134_RS14095	COG2895	sulfate adenylyltransferase (ATP) activity
IXO134_RS14095	COG0529	Catalyzes the synthesis of activated sulfate
IXO134_RS14130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO134_RS14145	COG2040	homocysteine
IXO134_RS14150	COG0833	amino acid
IXO134_RS14170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO134_RS14170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO134_RS14180	COG2878	Part of a membrane complex involved in electron transport
IXO134_RS14195	COG1595	DNA-templated transcription, initiation
IXO134_RS14220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO134_RS14235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO134_RS14240	COG0251	oxidation-reduction process
IXO134_RS14250	COG0392	lysyltransferase activity
IXO134_RS14250	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO134_RS14280	COG3039	Transposase
IXO134_RS14290	COG2814	Major facilitator Superfamily
IXO134_RS14295	COG1902	pentaerythritol trinitrate reductase activity
IXO134_RS14305	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO134_RS14320	COG1047	Peptidyl-prolyl cis-trans
IXO134_RS14360	COG3039	Transposase
IXO134_RS14365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO134_RS14380	COG1451	nucleotide metabolic process
IXO134_RS14400	COG0183	Belongs to the thiolase family
IXO134_RS14430	COG1793	dna ligase
IXO134_RS14430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO134_RS14440	COG1793	dna ligase
IXO134_RS14445	COG1201	RNA secondary structure unwinding
IXO134_RS14465	COG1278	Cold shock
IXO134_RS14470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO134_RS14475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO134_RS14485	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO134_RS14495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO134_RS14520	COG3039	Transposase
IXO134_RS14530	COG2954	triphosphatase activity
IXO134_RS14545	COG1381	Involved in DNA repair and RecF pathway recombination
IXO134_RS14575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO134_RS14590	COG1024	Enoyl-CoA hydratase
IXO134_RS14590	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO134_RS14610	COG1024	Enoyl-CoA hydratase
IXO134_RS14615	COG1960	acyl-CoA dehydrogenase activity
IXO134_RS14685	COG2353	YceI-like domain
IXO134_RS14695	COG2353	YceI-like domain
IXO134_RS14710	COG1760	l-serine dehydratase
IXO134_RS14720	COG0626	cystathionine gamma-synthase activity
IXO134_RS14725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO134_RS14730	COG0739	heme binding
IXO134_RS14740	COG1272	protein, Hemolysin III
IXO134_RS14765	COG0463	Glycosyl transferase, family 2
IXO134_RS14775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO134_RS14785	COG4771	TonB-dependent receptor
IXO134_RS14790	COG1309	transcriptional regulator
IXO134_RS14800	COG1960	acyl-CoA dehydrogenase activity
IXO134_RS14830	COG0509	glycine decarboxylation via glycine cleavage system
IXO134_RS14845	COG0330	HflC and HflK could
IXO134_RS14860	COG3956	TIGRFAM MazG family protein
IXO134_RS14870	COG0494	nUDIX hydrolase
IXO134_RS14880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO134_RS14885	COG0837	glucose binding
IXO134_RS14900	COG1388	LysM domain
IXO134_RS14900	COG3858	chitin binding
IXO134_RS14910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO134_RS14920	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO134_RS14960	COG3537	Alpha-1,2-mannosidase
IXO134_RS15000	COG3142	Participates in the control of copper homeostasis
IXO134_RS15005	COG1446	asparaginase
IXO134_RS15015	COG2304	oxidoreductase activity
IXO134_RS15020	COG2304	oxidoreductase activity
IXO134_RS15060	COG2198	Histidine kinase
IXO134_RS15060	COG0784	Response regulator, receiver
IXO134_RS15060	COG0643	Histidine kinase
IXO134_RS15065	COG0840	transmembrane signaling receptor activity
IXO134_RS15070	COG0835	chemotaxis
IXO134_RS15085	COG0189	ligase activity
IXO134_RS15095	COG1397	ADP-ribosylglycohydrolase
IXO134_RS15105	COG1199	ATP-dependent helicase activity
IXO134_RS15115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO134_RS15120	COG1215	transferase activity, transferring glycosyl groups
IXO134_RS15130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO134_RS15145	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IXO134_RS15150	COG0535	radical SAM domain protein
IXO134_RS15155	COG0535	radical SAM domain protein
IXO134_RS15190	COG1643	Atp-dependent helicase
IXO134_RS15195	COG0783	Belongs to the Dps family
IXO134_RS15200	COG0514	ATP-dependent DNA helicase (RecQ)
IXO134_RS15225	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO134_RS15280	COG1187	pseudouridine synthase activity
IXO134_RS15285	COG0602	queuosine metabolic process
IXO134_RS15295	COG2885	chlorophyll binding
IXO134_RS15310	COG0848	biopolymer transport protein
IXO134_RS15320	COG0824	Thioesterase
IXO134_RS15325	COG2255	four-way junction helicase activity
IXO134_RS15335	COG0632	four-way junction helicase activity
IXO134_RS15470	COG3209	COG3209 Rhs family protein
IXO134_RS15495	COG3209	COG3209 Rhs family protein
IXO134_RS15495	COG3209	COG3209 Rhs family protein
IXO134_RS15520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO134_RS15525	COG1845	cytochrome c oxidase, subunit III
IXO134_RS15530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO134_RS15545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO134_RS15550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO134_RS15560	COG0196	riboflavin kinase activity
IXO134_RS15565	COG0728	peptidoglycan biosynthetic process
IXO134_RS15570	COG0268	Binds directly to 16S ribosomal RNA
IXO134_RS15575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO134_RS15580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO134_RS15590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO134_RS15595	COG0824	Thioesterase
IXO134_RS15610	COG1946	Acyl-CoA thioesterase
IXO134_RS15635	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO134_RS15675	COG1877	trehalose-phosphatase activity
IXO134_RS15680	COG3387	PFAM Glycoside hydrolase 15-related
IXO134_RS15705	COG0564	pseudouridine synthase activity
IXO134_RS15710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_RS15715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO134_RS15715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO134_RS15725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO134_RS15730	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO134_RS15755	COG2184	nucleotidyltransferase activity
IXO134_RS15775	COG2194	sulfuric ester hydrolase activity
IXO134_RS15780	COG4969	Belongs to the N-Me-Phe pilin family
IXO134_RS15790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO134_RS15810	COG3039	Transposase
IXO134_RS15860	COG1132	(ABC) transporter
IXO134_RS15890	COG0745	RESPONSE REGULATOR receiver
IXO134_RS15895	COG5000	phosphorelay sensor kinase activity
IXO134_RS15895	COG5002	protein histidine kinase activity
IXO134_RS15900	COG0475	glutathione-regulated potassium exporter activity
IXO134_RS15910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO134_RS15930	COG1187	pseudouridine synthase activity
IXO134_RS15935	COG5001	Diguanylate cyclase
IXO134_RS15935	COG5002	protein histidine kinase activity
IXO134_RS16050	COG0415	Belongs to the DNA photolyase family
IXO134_RS16055	COG0305	Participates in initiation and elongation during chromosome replication
IXO134_RS16065	COG0367	asparagine synthase
IXO134_RS16080	COG1960	acyl-CoA dehydrogenase activity
IXO134_RS16095	COG0084	hydrolase, TatD family'
IXO134_RS16100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO134_RS16160	COG0735	belongs to the Fur family
IXO134_RS16165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO134_RS16185	COG3039	Transposase
IXO134_RS16195	COG3039	Transposase
IXO134_RS16265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO134_RS16275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO134_RS16290	COG2198	Histidine kinase
IXO134_RS16290	COG0643	Histidine kinase
IXO134_RS16300	COG0835	chemotaxis
IXO134_RS16305	COG2199	diguanylate cyclase activity
IXO134_RS16305	COG2200	EAL domain
IXO134_RS16305	COG2202	Pas domain
IXO134_RS16310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO134_RS16325	COG3590	peptidase
IXO134_RS16340	COG0588	phosphoglycerate mutase activity
IXO134_RS16345	COG1515	deoxyribonuclease V activity
IXO134_RS16355	COG1741	Belongs to the pirin family
IXO134_RS16420	COG1741	Belongs to the pirin family
IXO134_RS16425	COG1966	Carbon starvation protein
IXO134_RS16430	COG2879	small protein
IXO134_RS16470	COG5001	Diguanylate cyclase
IXO134_RS16470	COG3706	GGDEF domain
IXO134_RS16470	COG2203	Gaf domain
IXO134_RS16470	COG4251	negative regulation of phosphorylation
IXO134_RS16475	COG0629	single-stranded DNA binding
IXO134_RS16480	COG0142	geranyltranstransferase activity
IXO134_RS16505	COG0527	aspartate kinase activity
IXO134_RS16515	COG0384	phenazine biosynthesis protein PhzF
IXO134_RS16525	COG1764	response to oxidative stress
IXO134_RS16540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO134_RS16545	COG1678	Uncharacterized ACR, COG1678
IXO134_RS16560	COG0519	Catalyzes the synthesis of GMP from XMP
IXO134_RS16590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO134_RS16650	COG1959	2 iron, 2 sulfur cluster binding
IXO134_RS16655	COG0719	Fe-S assembly protein
IXO134_RS16660	COG0396	ATPase activity
IXO134_RS16665	COG0719	Fe-S assembly protein
IXO134_RS16670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO134_RS16680	COG2146	nitrite reductase [NAD(P)H] activity
IXO134_RS16705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO134_RS16720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO134_RS16730	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO134_RS16735	COG0174	glutamine synthetase
IXO134_RS16740	COG3328	transposase activity
IXO134_RS16765	COG0326	Molecular chaperone. Has ATPase activity
IXO134_RS16770	COG2207	Transcriptional regulator
IXO134_RS16790	COG0657	acetylesterase activity
IXO134_RS16790	COG2755	lipolytic protein G-D-S-L family
IXO134_RS16815	COG0488	(ABC) transporter
IXO134_RS16850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO134_RS16850	COG4651	solute:proton antiporter activity
IXO134_RS16865	COG4772	TonB-dependent receptor
IXO134_RS16875	COG4264	IucA IucC family
IXO134_RS16880	COG2814	Major facilitator Superfamily
IXO134_RS16890	COG0019	diaminopimelate decarboxylase activity
IXO134_RS16955	COG4206	TonB-dependent receptor
IXO134_RS16990	COG0542	response to heat
IXO134_RS17030	COG0534	Mate efflux family protein
IXO134_RS17045	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO134_RS17050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO134_RS17055	COG0228	four-way junction DNA binding
IXO134_RS17075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO134_RS17085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO134_RS17130	COG1555	photosystem II stabilization
IXO134_RS17135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO134_RS17150	COG3178	'Phosphotransferase
IXO134_RS17155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO134_RS17165	COG0628	permease
IXO134_RS17175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO134_RS17190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO134_RS17215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO134_RS17220	COG0271	Belongs to the BolA IbaG family
IXO134_RS17230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO134_RS17240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO134_RS17245	COG1137	ATPase activity
IXO134_RS17260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO134_RS17265	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO134_RS17270	COG1660	Displays ATPase and GTPase activities
IXO134_RS17285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO134_RS17290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO134_RS17295	COG2239	Acts as a magnesium transporter
IXO134_RS17305	COG1294	oxidase, subunit
IXO134_RS17310	COG1271	oxidase subunit
IXO134_RS17325	COG1113	amino acid transport
IXO134_RS17340	COG2197	response regulator
IXO134_RS17345	COG0531	amino acid
IXO134_RS17405	COG0754	glutathionylspermidine amidase activity
IXO134_RS17430	COG1842	Phage shock protein A
IXO134_RS17445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO134_RS17450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO134_RS17460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO134_RS17545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO134_RS17595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO134_RS17600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO134_RS17630	COG3039	Transposase
IXO134_RS17645	COG0745	RESPONSE REGULATOR receiver
IXO134_RS17650	COG2205	protein histidine kinase activity
IXO134_RS17670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO134_RS17700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO134_RS17700	COG3453	Protein conserved in bacteria
IXO134_RS17705	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO134_RS17710	COG4149	molybdate abc transporter
IXO134_RS17715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO134_RS17735	COG0642	Histidine kinase
IXO134_RS17750	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS17760	COG1022	Amp-dependent synthetase and ligase
IXO134_RS17785	COG1376	ErfK ybiS ycfS ynhG family protein
IXO134_RS17790	COG0739	heme binding
IXO134_RS17800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO134_RS17805	COG1301	dicarboxylic acid transport
IXO134_RS17825	COG2304	oxidoreductase activity
IXO134_RS17845	COG0714	Associated with various cellular activities
IXO134_RS17890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO134_RS17915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO134_RS17925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO134_RS17950	COG1561	YicC-like family, N-terminal region
IXO134_RS17955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO134_RS17970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO134_RS18005	COG0006	proline dipeptidase activity
IXO134_RS18030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO134_RS18040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO134_RS18050	COG2912	Transglutaminase-like superfamily
IXO134_RS18055	COG1773	rubredoxin
IXO134_RS18060	COG0352	thiamine-phosphate diphosphorylase activity
IXO134_RS18130	COG0280	phosphate acetyltransferase
IXO134_RS18130	COG0281	malic enzyme
IXO134_RS18150	COG4191	Histidine kinase
IXO134_RS18165	COG0583	DNA-binding transcription factor activity
IXO134_RS18185	COG2197	response regulator
IXO134_RS18195	COG0642	Histidine kinase
IXO134_RS18210	COG2851	Citrate transporter
IXO134_RS18215	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS18220	COG1609	Transcriptional regulator
IXO134_RS18230	COG2211	Major facilitator Superfamily
IXO134_RS18255	COG1162	GTPase activity
IXO134_RS18280	COG0726	polysaccharide deacetylase
IXO134_RS18285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO134_RS18310	COG3039	Transposase
IXO134_RS18320	COG3039	Transposase
IXO134_RS18365	COG0242	peptide deformylase activity
IXO134_RS18385	COG0714	Associated with various cellular activities
IXO134_RS18405	COG0537	adenosine 5'-monophosphoramidase activity
IXO134_RS18435	COG0314	molybdopterin synthase activity
IXO134_RS18440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO134_RS18445	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO134_RS18455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO134_RS18460	COG1234	tRNA 3'-trailer cleavage
IXO134_RS18465	COG3642	lipopolysaccharide core region biosynthetic process
IXO134_RS18470	COG0859	PFAM glycosyl transferase family 9
IXO134_RS18480	COG0582	viral genome integration into host DNA
IXO134_RS18540	COG0631	protein serine/threonine phosphatase activity
IXO134_RS18550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO134_RS18575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO134_RS18615	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO134_RS18665	COG0473	3-isopropylmalate dehydrogenase activity
IXO134_RS18690	COG4783	chaperone-mediated protein folding
IXO134_RS18705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO134_RS18715	COG0438	transferase activity, transferring glycosyl groups
IXO134_RS18720	COG0671	phosphoesterase, PA-phosphatase related
IXO134_RS18725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO134_RS18745	COG2833	Protein of unknown function (DUF455)
IXO134_RS18765	COG0285	dihydrofolate synthase activity
IXO134_RS18775	COG0588	phosphoglycerate mutase activity
IXO134_RS18805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO134_RS18810	COG4208	sulfate ABC transporter
IXO134_RS18815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO134_RS18820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO134_RS18825	COG0156	8-amino-7-oxononanoate synthase activity
IXO134_RS18850	COG0604	alcohol dehydrogenase
IXO134_RS18855	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO134_RS18855	COG1902	pentaerythritol trinitrate reductase activity
IXO134_RS18980	COG3386	PFAM SMP-30 Gluconolaconase
IXO134_RS19000	COG1024	Enoyl-CoA hydratase
IXO134_RS19010	COG0318	PFAM AMP-dependent synthetase and ligase
IXO134_RS19015	COG0583	DNA-binding transcription factor activity
IXO134_RS19055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO134_RS19060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO134_RS19070	COG2096	Adenosyltransferase
IXO134_RS19075	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO134_RS19090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO134_RS19100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO134_RS19105	COG2967	ApaG domain
IXO134_RS19130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO134_RS19150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO134_RS19170	COG0642	Histidine kinase
IXO134_RS19185	COG4181	ATPase activity
IXO134_RS19195	COG2175	clavaminate synthase activity
IXO134_RS19250	COG0667	Aldo Keto reductase
IXO134_RS19260	COG3039	Transposase
IXO134_RS19270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO134_RS19275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_RS19285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO134_RS19300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO134_RS19345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO134_RS19350	COG2226	methyltransferase
IXO134_RS19395	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS19395	COG0604	alcohol dehydrogenase
IXO134_RS19395	COG3321	synthase
IXO134_RS19405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO134_RS19420	COG0494	nUDIX hydrolase
IXO134_RS19435	COG1388	LysM domain
IXO134_RS19435	COG4942	peptidase
IXO134_RS19445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO134_RS19460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO134_RS19465	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO134_RS19470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO134_RS19485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO134_RS19490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO134_RS19505	COG3116	cell division
IXO134_RS19510	COG0275	rRNA processing
IXO134_RS19545	COG0792	nuclease activity
IXO134_RS19550	COG1988	membrane-bound metal-dependent
IXO134_RS19555	COG0277	FAD linked oxidase domain protein
IXO134_RS19560	COG0745	RESPONSE REGULATOR receiver
IXO134_RS19565	COG2205	protein histidine kinase activity
IXO134_RS19575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO134_RS19580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO134_RS19600	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO134_RS19605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO134_RS19610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO134_RS19630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO134_RS19630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO134_RS19650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO134_RS19670	COG0488	(ABC) transporter
IXO134_RS19695	COG3791	Glutathione-dependent formaldehyde-activating
IXO134_RS19725	COG2205	protein histidine kinase activity
IXO134_RS19785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO134_RS19820	COG3039	Transposase
IXO134_RS19845	COG3039	Transposase
IXO134_RS19930	COG0726	polysaccharide deacetylase
IXO134_RS19930	COG1649	PFAM Uncharacterised BCR, COG1649
IXO134_RS19935	COG1215	transferase activity, transferring glycosyl groups
IXO134_RS19945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO134_RS19950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO134_RS19955	COG1609	Transcriptional regulator
IXO134_RS19965	COG2188	Transcriptional regulator
IXO134_RS19980	COG3250	beta-galactosidase activity
IXO134_RS20030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO134_RS20035	COG4191	Histidine kinase
IXO134_RS20040	COG0784	Response regulator, receiver
IXO134_RS20045	COG4251	negative regulation of phosphorylation
IXO134_RS20050	COG2823	Periplasmic or secreted lipoprotein
IXO134_RS20055	COG0673	inositol 2-dehydrogenase activity
IXO134_RS20060	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO134_RS20095	COG1056	cytidyltransferase-related domain
IXO134_RS20095	COG1051	belongs to the nudix hydrolase family
IXO134_RS20120	COG2921	Belongs to the UPF0250 family
IXO134_RS20135	COG1686	Belongs to the peptidase S11 family
IXO134_RS20140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO134_RS20145	COG2951	lytic endotransglycosylase activity
IXO134_RS20215	COG0772	Belongs to the SEDS family
IXO134_RS20230	COG1792	Involved in formation and maintenance of cell shape
IXO134_RS20235	COG1077	Cell shape determining protein MreB Mrl
IXO134_RS20240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_RS20290	COG2199	diguanylate cyclase activity
IXO134_RS20295	COG0308	aminopeptidase N
IXO134_RS20325	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO134_RS20355	COG0436	Aminotransferase
IXO134_RS20360	COG3039	Transposase
IXO134_RS20365	COG3039	Transposase
IXO134_RS20385	COG1505	serine-type exopeptidase activity
IXO134_RS20410	COG0181	hydroxymethylbilane synthase activity
IXO134_RS20420	COG3275	phosphorelay sensor kinase activity
IXO134_RS20455	COG0659	secondary active sulfate transmembrane transporter activity
IXO134_RS20460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_RS20460	COG5297	Belongs to the glycosyl hydrolase family 6
IXO134_RS20535	COG0598	Magnesium transport protein CorA
IXO134_RS20545	COG1113	amino acid transport
IXO134_RS20555	COG5297	Belongs to the glycosyl hydrolase family 6
IXO134_RS20560	COG4305	rare lipoprotein A
IXO134_RS20565	COG0697	spore germination
IXO134_RS20625	COG4221	oxidoreductase activity
IXO134_RS20655	COG0456	acetyltransferase
IXO134_RS20665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO134_RS20705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO134_RS20705	COG2111	Na H antiporter
IXO134_RS20710	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO134_RS20715	COG0651	ATP synthesis coupled electron transport
IXO134_RS20725	COG2212	antiporter activity
IXO134_RS20730	COG1320	monovalent cation:proton antiporter activity
IXO134_RS20745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO134_RS20765	COG3104	oligopeptide transport
IXO134_RS20770	COG3483	tryptophan 2,3-dioxygenase activity
IXO134_RS20815	COG0183	Belongs to the thiolase family
IXO134_RS20860	COG3039	Transposase
IXO134_RS20895	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO134_RS20915	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_RS20940	COG0531	amino acid
IXO134_RS20965	COG4682	membrane
IXO134_RS20975	COG2133	pyrroloquinoline quinone binding
IXO134_RS21015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO134_RS21020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO134_RS21030	COG1610	YqeY-like protein
IXO134_RS21040	COG1295	ribonuclease BN
IXO134_RS21045	COG0358	DNA primase activity
IXO134_RS21110	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO134_RS21125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO134_RS21175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO134_RS21180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO134_RS21185	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO134_RS21195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO134_RS21200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO134_RS21210	COG0134	indole-3-glycerol-phosphate synthase activity
IXO134_RS21215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO134_RS21280	COG3039	Transposase
IXO134_RS21295	COG3039	Transposase
IXO134_RS21305	COG3328	transposase activity
IXO134_RS21315	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO134_RS21315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO134_RS21325	COG1473	amidohydrolase
IXO134_RS21330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_RS21335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO134_RS21345	COG5383	Protein conserved in bacteria
IXO134_RS21380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO134_RS21385	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO134_RS21400	COG0028	Belongs to the TPP enzyme family
IXO134_RS21405	COG4191	Histidine kinase
IXO134_RS21430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO134_RS21445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO134_RS21450	COG3177	Filamentation induced by cAMP protein fic
IXO134_RS21465	COG0596	Alpha beta hydrolase
IXO134_RS21470	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO134_RS21475	COG0318	PFAM AMP-dependent synthetase and ligase
IXO134_RS21480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO134_RS21530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO134_RS21540	COG0129	dihydroxy-acid dehydratase activity
IXO134_RS21560	COG3039	Transposase
IXO134_RS21570	COG0408	coproporphyrinogen oxidase activity
IXO134_RS21610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO134_RS21685	COG2353	YceI-like domain
IXO134_RS21715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO134_RS21730	COG3386	PFAM SMP-30 Gluconolaconase
IXO134_RS21755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO134_RS21775	COG0459	protein refolding
IXO134_RS21800	COG1252	NADH dehydrogenase
IXO134_RS21810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO134_RS21815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO134_RS21820	COG2201	protein-glutamate methylesterase activity
IXO134_RS21825	COG2177	Part of the ABC transporter FtsEX involved in
IXO134_RS21830	COG2884	Cell division ATP-binding protein ftsE
IXO134_RS21840	COG3118	belongs to the thioredoxin family
IXO134_RS21845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO134_RS21860	COG0729	surface antigen
IXO134_RS21865	COG2911	Protein conserved in bacteria
IXO134_RS21915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO134_RS21965	COG1733	regulation of RNA biosynthetic process
IXO134_RS21970	COG0702	epimerase
IXO134_RS22000	COG0583	DNA-binding transcription factor activity
IXO134_RS22005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO134_RS22025	COG0745	RESPONSE REGULATOR receiver
IXO134_RS22055	COG1902	pentaerythritol trinitrate reductase activity
IXO134_RS22060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO134_RS22070	COG2814	Major facilitator Superfamily
IXO134_RS22075	COG0583	DNA-binding transcription factor activity
IXO134_RS22090	COG0084	hydrolase, TatD family'
IXO134_RS22135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO134_RS22160	COG2351	hydroxyisourate hydrolase activity
IXO134_RS22220	COG4770	biotin carboxylase activity
IXO134_RS22225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO134_RS22230	COG1960	acyl-CoA dehydrogenase activity
IXO134_RS22280	COG0523	cobalamin synthesis protein
IXO134_RS22300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO134_RS22320	COG4771	TonB-dependent receptor
IXO134_RS22325	COG0457	Tetratricopeptide repeat
IXO134_RS22335	COG0752	glycyl-tRNA synthetase alpha subunit
IXO134_RS22340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO134_RS22355	COG0519	Catalyzes the synthesis of GMP from XMP
IXO134_RS22355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO134_RS22365	COG0805	protein transport
IXO134_RS22375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO134_RS22385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO134_RS22410	COG2974	May be involved in recombination
IXO134_RS22415	COG0037	tRNA processing
IXO134_RS22435	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO134_RS22445	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_RS22455	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO134_RS22460	COG0246	Mannitol dehydrogenase
IXO134_RS22485	COG3693	PFAM glycoside hydrolase, family 10
IXO134_RS22510	COG2211	Major facilitator Superfamily
IXO134_RS22595	COG1846	Transcriptional regulator
IXO134_RS22600	COG1764	response to oxidative stress
IXO134_RS22680	COG3549	Plasmid maintenance system killer
IXO134_RS22690	COG1074	ATP-dependent DNA helicase activity
IXO134_RS22695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO134_RS22710	COG1196	nuclear chromosome segregation
IXO134_RS22745	COG2032	superoxide dismutase activity
IXO134_RS22750	COG2032	superoxide dismutase activity
IXO134_RS22755	COG2204	response regulator
IXO134_RS22760	COG3852	Histidine kinase
IXO134_RS22765	COG0004	ammonium transporteR
IXO134_RS22770	COG0347	Belongs to the P(II) protein family
IXO134_RS22775	COG0174	glutamine synthetase
IXO134_RS22780	COG1968	undecaprenyl-diphosphatase activity
IXO134_RS22820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO134_RS22830	COG2062	phosphohistidine phosphatase, SixA
IXO134_RS22835	COG0489	protein tyrosine kinase activity
IXO134_RS22855	COG1396	sequence-specific DNA binding
IXO134_RS22860	COG3550	peptidyl-serine autophosphorylation
IXO134_RS22865	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO134_RS22870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_RS22885	COG0517	IMP dehydrogenase activity
IXO134_RS22885	COG1125	glycine betaine transport
IXO134_RS22900	COG1119	ATPase activity
IXO134_RS22910	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO134_RS22925	COG3039	Transposase
IXO134_RS22950	COG0656	L-ascorbic acid biosynthetic process
IXO134_RS22955	COG2130	NADP-dependent
IXO134_RS22960	COG0667	Aldo Keto reductase
IXO134_RS22970	COG1187	pseudouridine synthase activity
IXO134_RS22980	COG1643	Atp-dependent helicase
IXO134_RS22985	COG4807	Protein conserved in bacteria
IXO134_RS22990	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_RS22995	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO134_RS23000	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_RS23060	COG3162	membrane
IXO134_RS23065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO134_RS23080	COG0708	Exodeoxyribonuclease III
IXO134_RS23095	COG2091	lysine biosynthetic process via aminoadipic acid
IXO134_RS23105	COG3540	Alkaline phosphatase
IXO134_RS23110	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO134_RS23130	COG2159	amidohydrolase
IXO134_RS23140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO134_RS23145	COG0583	DNA-binding transcription factor activity
IXO134_RS23150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO134_RS23165	COG0210	DNA helicase
IXO134_RS23180	COG0531	amino acid
IXO134_RS23190	COG1322	Protein conserved in bacteria
IXO134_RS23200	COG0386	Belongs to the glutathione peroxidase family
IXO134_RS23255	COG0793	Belongs to the peptidase S41A family
IXO134_RS23260	COG4942	peptidase
IXO134_RS23270	COG2234	aminopeptidase activity
IXO134_RS23315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO134_RS23320	COG0302	gtp cyclohydrolase
IXO134_RS23340	COG0477	Major facilitator Superfamily
IXO134_RS23435	COG1929	Belongs to the glycerate kinase type-1 family
IXO134_RS23440	COG2271	Major facilitator Superfamily
IXO134_RS23455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO134_RS23460	COG0861	Integral membrane protein TerC family
IXO134_RS23470	COG0584	glycerophosphoryl diester phosphodiesterase
IXO134_RS23480	COG0671	phosphoesterase, PA-phosphatase related
IXO134_RS23490	COG0726	polysaccharide deacetylase
IXO134_RS23610	COG0489	protein tyrosine kinase activity
IXO134_RS23640	COG3039	Transposase
IXO134_RS23700	COG3704	protein secretion by the type IV secretion system
IXO134_RS23710	COG3504	Conjugal transfer protein