locus-tag	class	description
IXO220_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO220_RS00020	COG0187	DNA topoisomerase II activity
IXO220_RS00030	COG0501	Belongs to the peptidase M48B family
IXO220_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO220_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO220_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO220_RS00090	COG4772	TonB-dependent receptor
IXO220_RS00105	COG3039	Transposase
IXO220_RS00110	COG1304	FMN binding
IXO220_RS00130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO220_RS00140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_RS00225	COG2826	transposase and inactivated derivatives, IS30 family
IXO220_RS00250	COG3039	Transposase
IXO220_RS00260	COG1090	epimerase
IXO220_RS00280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO220_RS00390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO220_RS00465	COG3264	Mechanosensitive ion channel
IXO220_RS00465	COG1511	domain protein
IXO220_RS00480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO220_RS00485	COG2354	Protein conserved in bacteria
IXO220_RS00490	COG1649	PFAM Uncharacterised BCR, COG1649
IXO220_RS00510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO220_RS00535	COG0702	epimerase
IXO220_RS00550	COG1858	cytochrome C peroxidase
IXO220_RS00625	COG0513	Belongs to the DEAD box helicase family
IXO220_RS00630	COG3039	Transposase
IXO220_RS00675	COG1136	(ABC) transporter
IXO220_RS00715	COG1136	(ABC) transporter
IXO220_RS00755	COG1272	protein, Hemolysin III
IXO220_RS00760	COG1111	helicase
IXO220_RS00760	COG1205	dead DEAH box helicase
IXO220_RS00820	COG0069	glutamate synthase activity
IXO220_RS00820	COG0067	glutamate synthase
IXO220_RS00820	COG0070	glutamate synthase
IXO220_RS00825	COG0493	'glutamate synthase
IXO220_RS00870	COG1609	Transcriptional regulator
IXO220_RS00895	COG0366	Alpha amylase catalytic
IXO220_RS00900	COG0366	Alpha amylase catalytic
IXO220_RS00945	COG0606	chelatase, subunit chli
IXO220_RS00985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO220_RS00990	COG1166	arginine decarboxylase activity
IXO220_RS01050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO220_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS01100	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO220_RS01115	COG0210	DNA helicase
IXO220_RS01130	COG3132	Protein of unknown function, DUF480
IXO220_RS01135	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO220_RS01140	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO220_RS01175	COG2937	Belongs to the GPAT DAPAT family
IXO220_RS01215	COG3186	Phenylalanine-4-hydroxylase
IXO220_RS01220	COG1522	sequence-specific DNA binding
IXO220_RS01265	COG1064	alcohol dehydrogenase
IXO220_RS01270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_RS01280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_RS01290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_RS01310	COG0676	glucose-6-phosphate 1-epimerase activity
IXO220_RS01375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO220_RS01400	COG2853	Lipoprotein
IXO220_RS01415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO220_RS01420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO220_RS01425	COG1127	ABC transporter
IXO220_RS01500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_RS01510	COG3039	Transposase
IXO220_RS01515	COG3265	gluconokinase activity
IXO220_RS01520	COG2211	Major facilitator Superfamily
IXO220_RS01525	COG3459	Glycosyltransferase 36 associated
IXO220_RS01535	COG2205	protein histidine kinase activity
IXO220_RS01545	COG1414	Transcriptional regulator
IXO220_RS01550	COG0738	Major facilitator superfamily
IXO220_RS01555	COG3254	rhamnose metabolic process
IXO220_RS01590	COG0339	signal peptide processing
IXO220_RS01620	COG0564	pseudouridine synthase activity
IXO220_RS01630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO220_RS01640	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO220_RS01705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO220_RS01715	COG0842	Transport permease protein
IXO220_RS01720	COG1131	(ABC) transporter
IXO220_RS01750	COG1476	TRANSCRIPTIONal
IXO220_RS01760	COG4555	ABC transporter
IXO220_RS01795	COG0625	glutathione transferase activity
IXO220_RS01840	COG0583	DNA-binding transcription factor activity
IXO220_RS01880	COG1199	ATP-dependent helicase activity
IXO220_RS01920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO220_RS01950	COG3228	Belongs to the MtfA family
IXO220_RS01960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO220_RS01960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO220_RS01965	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO220_RS01980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO220_RS02015	COG3237	CsbD-like
IXO220_RS02020	COG0180	Tryptophanyl-tRNA synthetase
IXO220_RS02025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO220_RS02070	COG0753	catalase activity
IXO220_RS02085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO220_RS02095	COG0628	permease
IXO220_RS02105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO220_RS02110	COG1040	competence protein
IXO220_RS02115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO220_RS02120	COG0156	8-amino-7-oxononanoate synthase activity
IXO220_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS02145	COG0463	Glycosyl transferase, family 2
IXO220_RS02155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO220_RS02160	COG3100	YcgL domain-containing protein
IXO220_RS02175	COG3387	PFAM Glycoside hydrolase 15-related
IXO220_RS02180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO220_RS02195	COG2239	Acts as a magnesium transporter
IXO220_RS02210	COG1042	CoA-binding domain protein
IXO220_RS02210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO220_RS02210	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO220_RS02220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO220_RS02225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO220_RS02265	COG3485	protocatechuate 3,4-dioxygenase
IXO220_RS02285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO220_RS02290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO220_RS02315	COG4221	oxidoreductase activity
IXO220_RS02340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO220_RS02365	COG0463	Glycosyl transferase, family 2
IXO220_RS02380	COG1475	DNA binding
IXO220_RS02385	COG1192	Involved in chromosome partitioning
IXO220_RS02400	COG0708	Exodeoxyribonuclease III
IXO220_RS02405	COG2211	Major facilitator Superfamily
IXO220_RS02420	COG0739	heme binding
IXO220_RS02465	COG0745	RESPONSE REGULATOR receiver
IXO220_RS02500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO220_RS02515	COG2814	Major facilitator Superfamily
IXO220_RS02530	COG1289	transmembrane transporter activity
IXO220_RS02550	COG1136	(ABC) transporter
IXO220_RS02550	COG0577	efflux transmembrane transporter activity
IXO220_RS02555	COG0151	Belongs to the GarS family
IXO220_RS02565	COG0138	bifunctional purine biosynthesis protein purh
IXO220_RS02580	COG3039	Transposase
IXO220_RS02605	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO220_RS02645	COG0439	Biotin carboxylase
IXO220_RS02655	COG0511	ligase activity, forming carbon-carbon bonds
IXO220_RS02660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO220_RS02670	COG1324	tolerance protein
IXO220_RS02710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO220_RS02730	COG0534	Mate efflux family protein
IXO220_RS02735	COG0616	signal peptide processing
IXO220_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS02760	COG0009	L-threonylcarbamoyladenylate synthase
IXO220_RS02765	COG1754	DNA topoisomerase type I activity
IXO220_RS02765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO220_RS02780	COG2922	Belongs to the Smg family
IXO220_RS02785	COG0758	DNA mediated transformation
IXO220_RS02790	COG1652	LysM domain
IXO220_RS02795	COG0242	peptide deformylase activity
IXO220_RS02800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO220_RS02805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO220_RS02805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO220_RS02855	COG1560	Kdo2-lipid A biosynthetic process
IXO220_RS02865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO220_RS03015	COG3039	Transposase
IXO220_RS03025	COG1271	oxidase subunit
IXO220_RS03090	COG0531	amino acid
IXO220_RS03110	COG3590	peptidase
IXO220_RS03120	COG0667	Aldo Keto reductase
IXO220_RS03135	COG3384	dioxygenase
IXO220_RS03145	COG1573	uracil-dna glycosylase
IXO220_RS03155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO220_RS03165	COG0025	NhaP-type Na H and K H
IXO220_RS03170	COG1131	(ABC) transporter
IXO220_RS03175	COG0842	Transport permease protein
IXO220_RS03190	COG1404	Belongs to the peptidase S8 family
IXO220_RS03205	COG0745	RESPONSE REGULATOR receiver
IXO220_RS03255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_RS03280	COG2202	Pas domain
IXO220_RS03280	COG2205	protein histidine kinase activity
IXO220_RS03310	COG2813	Specifically methylates the guanine in position
IXO220_RS03315	COG1187	pseudouridine synthase activity
IXO220_RS03320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO220_RS03355	COG0697	spore germination
IXO220_RS03365	COG2011	ABC-type metal ion transport system permease component
IXO220_RS03395	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO220_RS03405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO220_RS03425	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO220_RS03435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO220_RS03445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO220_RS03450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO220_RS03455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO220_RS03460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO220_RS03510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_RS03515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO220_RS03565	COG0339	signal peptide processing
IXO220_RS03600	COG1956	GAF domain-containing protein
IXO220_RS03605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO220_RS03615	COG0720	synthase
IXO220_RS03620	COG0513	Belongs to the DEAD box helicase family
IXO220_RS03630	COG0625	glutathione transferase activity
IXO220_RS03660	COG0626	cystathionine gamma-synthase activity
IXO220_RS03700	COG3328	transposase activity
IXO220_RS03725	COG2086	electron transfer activity
IXO220_RS03750	COG0662	Cupin 2, conserved barrel domain protein
IXO220_RS03750	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO220_RS03755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO220_RS03790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO220_RS03790	COG3218	ABC-type transport auxiliary lipoprotein component
IXO220_RS03795	COG1127	ABC transporter
IXO220_RS03800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO220_RS03820	COG0442	prolyl-tRNA aminoacylation
IXO220_RS03830	COG1183	phosphatidylcholine synthase activity
IXO220_RS03860	COG3039	Transposase
IXO220_RS03895	COG3039	Transposase
IXO220_RS03925	COG0525	valine-tRNA ligase activity
IXO220_RS03940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO220_RS03950	COG0795	lipopolysaccharide-transporting ATPase activity
IXO220_RS03965	COG4974	Belongs to the 'phage' integrase family
IXO220_RS03970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO220_RS03975	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO220_RS03975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO220_RS03980	COG5295	Hep Hag repeat protein
IXO220_RS03990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO220_RS04000	COG1459	type II secretion system
IXO220_RS04005	COG2165	general secretion pathway protein
IXO220_RS04010	COG4970	Tfp pilus assembly protein FimT
IXO220_RS04015	COG2165	general secretion pathway protein
IXO220_RS04020	COG4795	General secretion pathway protein
IXO220_RS04025	COG3156	type II secretion system protein K
IXO220_RS04030	COG3166	PFAM Fimbrial assembly family protein
IXO220_RS04045	COG1450	Type ii and iii secretion system protein
IXO220_RS04060	COG2188	Transcriptional regulator
IXO220_RS04105	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO220_RS04110	COG1518	maintenance of DNA repeat elements
IXO220_RS04145	COG3039	Transposase
IXO220_RS04160	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO220_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS04190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO220_RS04200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO220_RS04205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO220_RS04240	COG3829	transcription factor binding
IXO220_RS04320	COG2826	transposase and inactivated derivatives, IS30 family
IXO220_RS04330	COG0678	peroxiredoxin activity
IXO220_RS04350	COG0330	HflC and HflK could
IXO220_RS04355	COG0330	HflC and HflK could
IXO220_RS04365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO220_RS04370	COG0308	aminopeptidase N
IXO220_RS04430	COG1560	Kdo2-lipid A biosynthetic process
IXO220_RS04435	COG1519	Transferase
IXO220_RS04440	COG1538	Outer membrane efflux protein
IXO220_RS04445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO220_RS04475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO220_RS04480	COG0066	3-isopropylmalate dehydratase activity
IXO220_RS04485	COG2226	methyltransferase
IXO220_RS04515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO220_RS04525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO220_RS04530	COG3710	Transcriptional regulator
IXO220_RS04555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO220_RS04575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO220_RS04610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO220_RS04620	COG3781	membrane
IXO220_RS04755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO220_RS04775	COG1217	gtp-binding protein TYPA
IXO220_RS04780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO220_RS04785	COG0039	L-malate dehydrogenase activity
IXO220_RS04790	COG0625	glutathione transferase activity
IXO220_RS04805	COG3039	Transposase
IXO220_RS04830	COG0584	glycerophosphoryl diester phosphodiesterase
IXO220_RS04865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO220_RS04900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO220_RS04905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO220_RS04910	COG0583	DNA-binding transcription factor activity
IXO220_RS04915	COG3634	alkyl hydroperoxide reductase activity
IXO220_RS04925	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO220_RS04965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO220_RS04965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO220_RS04980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO220_RS05005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO220_RS05030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO220_RS05040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO220_RS05070	COG1295	ribonuclease BN
IXO220_RS05075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO220_RS05095	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO220_RS05105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO220_RS05110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO220_RS05120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO220_RS05135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO220_RS05145	COG0193	aminoacyl-tRNA hydrolase activity
IXO220_RS05150	COG0012	GTP binding
IXO220_RS05180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO220_RS05185	COG0250	Participates in transcription elongation, termination and antitermination
IXO220_RS05190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO220_RS05200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO220_RS05205	COG0222	ribosome binding
IXO220_RS05210	COG0085	RNA polymerase activity
IXO220_RS05215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO220_RS05220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO220_RS05225	COG0049	tRNA binding
IXO220_RS05245	COG0051	transcription antitermination factor activity, RNA binding
IXO220_RS05250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO220_RS05255	COG0088	Forms part of the polypeptide exit tunnel
IXO220_RS05260	COG0089	rRNA binding
IXO220_RS05275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO220_RS05285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO220_RS05290	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO220_RS05295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO220_RS05300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO220_RS05310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO220_RS05340	COG1841	ribosomal large subunit assembly
IXO220_RS05350	COG0201	protein transport
IXO220_RS05360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO220_RS05365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO220_RS05375	COG0203	ribosomal protein L17
IXO220_RS05435	COG3551	Protein conserved in bacteria
IXO220_RS05465	COG2194	sulfuric ester hydrolase activity
IXO220_RS05475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO220_RS05480	COG0745	RESPONSE REGULATOR receiver
IXO220_RS05485	COG0642	Histidine kinase
IXO220_RS05495	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO220_RS05500	COG2894	cell division
IXO220_RS05515	COG4585	Histidine kinase
IXO220_RS05520	COG2197	response regulator
IXO220_RS05535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO220_RS05560	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO220_RS05675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO220_RS05820	COG3039	Transposase
IXO220_RS05835	COG3039	Transposase
IXO220_RS05895	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO220_RS05915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO220_RS05920	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO220_RS05925	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO220_RS05940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO220_RS06015	COG0587	DNA-directed DNA polymerase activity
IXO220_RS06030	COG1297	OPT oligopeptide transporter protein
IXO220_RS06050	COG0823	Involved in the tonB-independent uptake of proteins
IXO220_RS06050	COG1506	peptidase
IXO220_RS06070	COG1917	Cupin 2, conserved barrel domain protein
IXO220_RS06070	COG2207	Transcriptional regulator
IXO220_RS06095	COG0753	catalase activity
IXO220_RS06125	COG0126	phosphoglycerate kinase activity
IXO220_RS06135	COG0469	pyruvate kinase activity
IXO220_RS06140	COG3588	fructose-bisphosphate aldolase
IXO220_RS06145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO220_RS06190	COG0784	Response regulator, receiver
IXO220_RS06190	COG2198	Histidine kinase
IXO220_RS06190	COG2205	protein histidine kinase activity
IXO220_RS06210	COG0175	sulfate reduction
IXO220_RS06215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO220_RS06220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO220_RS06225	COG0175	sulfate reduction
IXO220_RS06230	COG0529	Catalyzes the synthesis of activated sulfate
IXO220_RS06230	COG2895	sulfate adenylyltransferase (ATP) activity
IXO220_RS06240	COG3039	Transposase
IXO220_RS06250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO220_RS06255	COG0308	aminopeptidase N
IXO220_RS06275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO220_RS06295	COG1970	mechanosensitive ion channel activity
IXO220_RS06325	COG0471	metal ion transport
IXO220_RS06325	COG3273	potassium ion transport
IXO220_RS06335	COG2022	thiamine diphosphate biosynthetic process
IXO220_RS06450	COG3118	belongs to the thioredoxin family
IXO220_RS06475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO220_RS06495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO220_RS06525	COG2968	Membrane
IXO220_RS06540	COG3164	Protein of unknown function
IXO220_RS06550	COG0312	modulator of DNA gyrase
IXO220_RS06555	COG3028	Belongs to the UPF0307 family
IXO220_RS06560	COG0312	modulator of DNA gyrase
IXO220_RS06585	COG0142	geranyltranstransferase activity
IXO220_RS06590	COG1722	exodeoxyribonuclease VII activity
IXO220_RS06595	COG0037	tRNA processing
IXO220_RS06600	COG1785	Belongs to the alkaline phosphatase family
IXO220_RS06620	COG0791	NLP P60 protein
IXO220_RS06625	COG0791	NLP P60 protein
IXO220_RS06630	COG1047	Peptidyl-prolyl cis-trans
IXO220_RS06635	COG2311	Membrane
IXO220_RS06640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_RS06680	COG0489	protein tyrosine kinase activity
IXO220_RS06685	COG0717	Belongs to the dCTP deaminase family
IXO220_RS06715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO220_RS06755	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO220_RS06760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO220_RS06765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO220_RS06770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO220_RS06790	COG0101	tRNA pseudouridine synthase activity
IXO220_RS06795	COG0135	phosphoribosylanthranilate isomerase activity
IXO220_RS06815	COG0159	tryptophan synthase activity
IXO220_RS06820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO220_RS06825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO220_RS06875	COG0149	triose-phosphate isomerase activity
IXO220_RS06890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO220_RS06900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO220_RS06905	COG0649	NAD binding
IXO220_RS06910	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO220_RS06915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO220_RS06920	COG1034	ATP synthesis coupled electron transport
IXO220_RS06925	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO220_RS06955	COG1007	ATP synthesis coupled electron transport
IXO220_RS06965	COG0779	Required for maturation of 30S ribosomal subunits
IXO220_RS06970	COG0195	Participates in both transcription termination and antitermination
IXO220_RS06975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO220_RS06990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO220_RS06995	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO220_RS07030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO220_RS07040	COG2095	MarC family integral membrane protein
IXO220_RS07055	COG1611	Belongs to the LOG family
IXO220_RS07265	COG3179	chitinase
IXO220_RS07310	COG4695	Portal protein
IXO220_RS07365	COG3039	Transposase
IXO220_RS07380	COG4969	Belongs to the N-Me-Phe pilin family
IXO220_RS07385	COG0556	nucleotide-excision repair
IXO220_RS07425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO220_RS07440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO220_RS07495	COG0438	transferase activity, transferring glycosyl groups
IXO220_RS07500	COG0438	transferase activity, transferring glycosyl groups
IXO220_RS07510	COG0438	transferase activity, transferring glycosyl groups
IXO220_RS07550	COG3040	lipid binding
IXO220_RS07625	COG0784	Response regulator, receiver
IXO220_RS07625	COG4191	Histidine kinase
IXO220_RS07645	COG0552	protein localization to endoplasmic reticulum
IXO220_RS07655	COG3938	Belongs to the proline racemase family
IXO220_RS07660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_RS07675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO220_RS07685	COG0006	proline dipeptidase activity
IXO220_RS07700	COG0531	amino acid
IXO220_RS07730	COG4206	TonB-dependent receptor
IXO220_RS07755	COG3328	transposase activity
IXO220_RS07815	COG0746	molybdenum cofactor guanylyltransferase activity
IXO220_RS07840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO220_RS07840	COG1648	precorrin-2 dehydrogenase activity
IXO220_RS07870	COG3039	Transposase
IXO220_RS07875	COG3039	Transposase
IXO220_RS07910	COG3039	Transposase
IXO220_RS07925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO220_RS07945	COG1054	Belongs to the UPF0176 family
IXO220_RS07960	COG1530	ribonuclease E activity
IXO220_RS07970	COG3064	Membrane
IXO220_RS07985	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO220_RS08035	COG3039	Transposase
IXO220_RS08150	COG0631	protein serine/threonine phosphatase activity
IXO220_RS08155	COG0515	serine threonine protein kinase
IXO220_RS08185	COG1858	cytochrome C peroxidase
IXO220_RS08240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_RS08265	COG2201	protein-glutamate methylesterase activity
IXO220_RS08310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO220_RS08330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO220_RS08345	COG1595	DNA-templated transcription, initiation
IXO220_RS08395	COG2244	polysaccharide biosynthetic process
IXO220_RS08425	COG2264	protein methyltransferase activity
IXO220_RS08435	COG0438	transferase activity, transferring glycosyl groups
IXO220_RS08450	COG1136	(ABC) transporter
IXO220_RS08455	COG1132	(ABC) transporter
IXO220_RS08465	COG0477	Major facilitator Superfamily
IXO220_RS08470	COG3039	Transposase
IXO220_RS08480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO220_RS08495	COG1253	flavin adenine dinucleotide binding
IXO220_RS08505	COG0306	phosphate transporter
IXO220_RS08535	COG0504	CTP synthase activity
IXO220_RS08540	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO220_RS08550	COG0148	phosphopyruvate hydratase activity
IXO220_RS08555	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO220_RS08560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO220_RS08570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO220_RS08580	COG2840	Smr protein MutS2
IXO220_RS08585	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO220_RS08590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO220_RS08595	COG1238	metal cluster binding
IXO220_RS08610	COG1534	Rna-binding protein
IXO220_RS08615	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO220_RS08625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO220_RS08640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO220_RS08645	COG1546	Belongs to the CinA family
IXO220_RS08660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO220_RS08665	COG2137	regulation of response to DNA damage stimulus
IXO220_RS08670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO220_RS08675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO220_RS08700	COG0305	Participates in initiation and elongation during chromosome replication
IXO220_RS08705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO220_RS08730	COG1741	Belongs to the pirin family
IXO220_RS08735	COG0583	DNA-binding transcription factor activity
IXO220_RS08760	COG0351	phosphomethylpyrimidine kinase
IXO220_RS08770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO220_RS08775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO220_RS08795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO220_RS08805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO220_RS08810	COG3734	2-keto-3-deoxy-galactonokinase
IXO220_RS08820	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_RS08825	COG0800	Aldolase
IXO220_RS08840	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO220_RS08850	COG1070	Carbohydrate kinase
IXO220_RS08860	COG0477	Major facilitator Superfamily
IXO220_RS08880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO220_RS08925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO220_RS08930	COG2258	MOSC domain
IXO220_RS08940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO220_RS08945	COG0505	Belongs to the CarA family
IXO220_RS08955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO220_RS08960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO220_RS08970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO220_RS09030	COG2205	protein histidine kinase activity
IXO220_RS09030	COG2198	Histidine kinase
IXO220_RS09030	COG0784	Response regulator, receiver
IXO220_RS09035	COG1024	Enoyl-CoA hydratase
IXO220_RS09040	COG0318	PFAM AMP-dependent synthetase and ligase
IXO220_RS09070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO220_RS09100	COG0840	transmembrane signaling receptor activity
IXO220_RS09120	COG3039	Transposase
IXO220_RS09135	COG0835	chemotaxis
IXO220_RS09150	COG0840	transmembrane signaling receptor activity
IXO220_RS09155	COG0840	transmembrane signaling receptor activity
IXO220_RS09160	COG0840	transmembrane signaling receptor activity
IXO220_RS09165	COG0840	transmembrane signaling receptor activity
IXO220_RS09175	COG0840	transmembrane signaling receptor activity
IXO220_RS09185	COG0840	transmembrane signaling receptor activity
IXO220_RS09215	COG0745	RESPONSE REGULATOR receiver
IXO220_RS09225	COG0835	chemotaxis
IXO220_RS09240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO220_RS09260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO220_RS09270	COG4771	TonB-dependent receptor
IXO220_RS09305	COG3039	Transposase
IXO220_RS09380	COG3501	Rhs element vgr protein
IXO220_RS09380	COG3409	Peptidoglycan-binding domain 1 protein
IXO220_RS09400	COG3501	Rhs element vgr protein
IXO220_RS09400	COG3409	Peptidoglycan-binding domain 1 protein
IXO220_RS09445	COG3039	Transposase
IXO220_RS09470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO220_RS09490	COG3039	Transposase
IXO220_RS09500	COG3039	Transposase
IXO220_RS09515	COG3039	Transposase
IXO220_RS09525	COG3039	Transposase
IXO220_RS09540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO220_RS09540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO220_RS09545	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO220_RS09550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO220_RS09550	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO220_RS09555	COG1609	Transcriptional regulator
IXO220_RS09580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO220_RS09585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_RS09595	COG2902	Dehydrogenase
IXO220_RS09600	COG3039	Transposase
IXO220_RS09610	COG5002	protein histidine kinase activity
IXO220_RS09610	COG2205	protein histidine kinase activity
IXO220_RS09610	COG0784	Response regulator, receiver
IXO220_RS09615	COG2733	membrane
IXO220_RS09625	COG1121	(ABC) transporter
IXO220_RS09630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO220_RS09635	COG2223	nitrite transmembrane transporter activity
IXO220_RS09645	COG0243	molybdopterin cofactor binding
IXO220_RS09655	COG0477	Major facilitator Superfamily
IXO220_RS09665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_RS09670	COG0174	glutamine synthetase
IXO220_RS09675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO220_RS09705	COG3842	ATPase activity
IXO220_RS09725	COG1012	belongs to the aldehyde dehydrogenase family
IXO220_RS09740	COG4535	Mg2 and Co2 transporter CorC
IXO220_RS09760	COG1702	phosphate starvation-inducible protein PhoH
IXO220_RS09785	COG0741	lytic transglycosylase activity
IXO220_RS09790	COG0723	plastoquinol--plastocyanin reductase activity
IXO220_RS09795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO220_RS09800	COG2857	Cytochrome c1
IXO220_RS09805	COG0625	glutathione transferase activity
IXO220_RS09810	COG2969	positive regulation of protein catabolic process
IXO220_RS09835	COG2094	Belongs to the DNA glycosylase MPG family
IXO220_RS09845	COG3328	transposase activity
IXO220_RS09915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO220_RS09935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO220_RS09940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO220_RS09940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO220_RS09945	COG0802	atpase or kinase
IXO220_RS09950	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO220_RS09955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO220_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS09985	COG0501	Belongs to the peptidase M48B family
IXO220_RS09995	COG2081	HI0933 family
IXO220_RS10000	COG4681	YaeQ
IXO220_RS10005	COG1671	Belongs to the UPF0178 family
IXO220_RS10015	COG0625	glutathione transferase activity
IXO220_RS10025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO220_RS10030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO220_RS10035	COG0513	Belongs to the DEAD box helicase family
IXO220_RS10040	COG0488	(ABC) transporter
IXO220_RS10060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO220_RS10065	COG0483	inositol monophosphate 1-phosphatase activity
IXO220_RS10080	COG3300	MHYT domain
IXO220_RS10080	COG5001	Diguanylate cyclase
IXO220_RS10085	COG1509	lysine 2,3-aminomutase activity
IXO220_RS10100	COG0402	S-adenosylhomocysteine deaminase activity
IXO220_RS10105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO220_RS10130	COG4677	pectinesterase activity
IXO220_RS10155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO220_RS10185	COG2166	iron-sulfur cluster assembly
IXO220_RS10200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO220_RS10205	COG0137	argininosuccinate synthase activity
IXO220_RS10215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO220_RS10220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO220_RS10235	COG0165	Argininosuccinate lyase
IXO220_RS10255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO220_RS10290	COG3039	Transposase
IXO220_RS10305	COG4988	ABC transporter
IXO220_RS10310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO220_RS10320	COG3039	Transposase
IXO220_RS10415	COG3039	Transposase
IXO220_RS10430	COG3209	COG3209 Rhs family protein
IXO220_RS10440	COG3039	Transposase
IXO220_RS10475	COG0643	Histidine kinase
IXO220_RS10475	COG0784	Response regulator, receiver
IXO220_RS10475	COG2198	Histidine kinase
IXO220_RS10530	COG1684	flagellar biosynthetic protein fliR
IXO220_RS10545	COG3190	flagellar
IXO220_RS10595	COG1677	Flagellar hook-basal body complex protein FliE
IXO220_RS10625	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS10635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO220_RS10655	COG2201	protein-glutamate methylesterase activity
IXO220_RS10690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO220_RS10695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO220_RS10730	COG4787	bacterial-type flagellum-dependent cell motility
IXO220_RS10740	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO220_RS10745	COG1558	bacterial-type flagellum-dependent cell motility
IXO220_RS10755	COG0784	Response regulator, receiver
IXO220_RS10755	COG0835	chemotaxis
IXO220_RS10775	COG5002	protein histidine kinase activity
IXO220_RS10785	COG4585	Histidine kinase
IXO220_RS10790	COG5001	Diguanylate cyclase
IXO220_RS10815	COG0482	sulfurtransferase activity
IXO220_RS10830	COG0542	response to heat
IXO220_RS10865	COG0492	ferredoxin-NADP+ reductase activity
IXO220_RS10870	COG1674	ftsk spoiiie
IXO220_RS10890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO220_RS10910	COG0038	chloride channel
IXO220_RS10915	COG0183	Belongs to the thiolase family
IXO220_RS10920	COG1024	Enoyl-CoA hydratase
IXO220_RS10920	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO220_RS10935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO220_RS10945	COG1426	Protein conserved in bacteria
IXO220_RS10955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_RS10965	COG0303	'Molybdopterin
IXO220_RS11020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO220_RS11070	COG0742	ribosomal rna small subunit methyltransferase
IXO220_RS11075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO220_RS11090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO220_RS11095	COG0405	Gamma-glutamyltransferase
IXO220_RS11120	COG3039	Transposase
IXO220_RS11195	COG0343	queuine tRNA-ribosyltransferase activity
IXO220_RS11200	COG1862	Preprotein translocase
IXO220_RS11205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO220_RS11210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO220_RS11220	COG3039	Transposase
IXO220_RS11250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO220_RS11260	COG0704	Plays a role in the regulation of phosphate uptake
IXO220_RS11275	COG0573	inorganic phosphate transmembrane transporter activity
IXO220_RS11280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO220_RS11330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO220_RS11340	COG1024	Enoyl-CoA hydratase
IXO220_RS11355	COG0494	nUDIX hydrolase
IXO220_RS11400	COG0116	Belongs to the methyltransferase superfamily
IXO220_RS11400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO220_RS11425	COG0667	Aldo Keto reductase
IXO220_RS11435	COG2925	Exonuclease
IXO220_RS11460	COG0288	reversible hydration of carbon dioxide
IXO220_RS11490	COG0316	Belongs to the HesB IscA family
IXO220_RS11495	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO220_RS11505	COG0359	binds to the 23S rRNA
IXO220_RS11515	COG3115	cell septum assembly
IXO220_RS11535	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO220_RS11555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO220_RS11580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO220_RS11590	COG2986	histidine ammonia-lyase
IXO220_RS11595	COG1228	amidohydrolase
IXO220_RS11635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO220_RS11645	COG1605	Chorismate mutase
IXO220_RS11645	COG0077	Prephenate dehydratase
IXO220_RS11650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO220_RS11680	COG4566	intracellular signal transduction
IXO220_RS11725	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO220_RS11730	COG1469	GTP cyclohydrolase I activity
IXO220_RS11740	COG0617	tRNA 3'-terminal CCA addition
IXO220_RS11750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO220_RS11755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO220_RS11785	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO220_RS11800	COG2203	Gaf domain
IXO220_RS11800	COG3706	GGDEF domain
IXO220_RS11800	COG4251	negative regulation of phosphorylation
IXO220_RS11800	COG5001	Diguanylate cyclase
IXO220_RS11860	COG1595	DNA-templated transcription, initiation
IXO220_RS11885	COG0386	Belongs to the glutathione peroxidase family
IXO220_RS11955	COG3039	Transposase
IXO220_RS11970	COG5002	protein histidine kinase activity
IXO220_RS11970	COG2205	protein histidine kinase activity
IXO220_RS11970	COG0784	Response regulator, receiver
IXO220_RS12010	COG0800	Aldolase
IXO220_RS12015	COG0129	dihydroxy-acid dehydratase activity
IXO220_RS12020	COG0363	glucosamine-6-phosphate deaminase activity
IXO220_RS12030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO220_RS12045	COG0354	folic acid binding
IXO220_RS12060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO220_RS12075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO220_RS12090	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO220_RS12115	COG0811	peptide transport
IXO220_RS12130	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO220_RS12140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO220_RS12150	COG0322	excinuclease ABC activity
IXO220_RS12185	COG3328	transposase activity
IXO220_RS12205	COG3039	Transposase
IXO220_RS12225	COG2201	protein-glutamate methylesterase activity
IXO220_RS12555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO220_RS12555	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO220_RS12565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO220_RS12575	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO220_RS12575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO220_RS12590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO220_RS12610	COG0124	histidyl-tRNA synthetase
IXO220_RS12625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO220_RS12660	COG1012	belongs to the aldehyde dehydrogenase family
IXO220_RS12690	COG0697	spore germination
IXO220_RS12715	COG0671	phosphoesterase, PA-phosphatase related
IXO220_RS12730	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO220_RS12745	COG2183	response to ionizing radiation
IXO220_RS12755	COG0723	plastoquinol--plastocyanin reductase activity
IXO220_RS12755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_RS12770	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO220_RS12780	COG1183	phosphatidylcholine synthase activity
IXO220_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS12810	COG0668	transmembrane transport
IXO220_RS12830	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO220_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS12880	COG0583	DNA-binding transcription factor activity
IXO220_RS12885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO220_RS12890	COG3002	Belongs to the UPF0753 family
IXO220_RS12905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO220_RS12925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO220_RS12935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO220_RS12940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO220_RS12950	COG0776	regulation of translation
IXO220_RS12955	COG0539	negative regulation of cytoplasmic translation
IXO220_RS12960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO220_RS12975	COG2957	Belongs to the agmatine deiminase family
IXO220_RS12985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO220_RS13010	COG0395	ABC-type sugar transport system, permease component
IXO220_RS13015	COG1175	transmembrane transport
IXO220_RS13045	COG2350	Protein conserved in bacteria
IXO220_RS13050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO220_RS13055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO220_RS13060	COG1187	pseudouridine synthase activity
IXO220_RS13085	COG0436	Aminotransferase
IXO220_RS13150	COG0277	FAD linked oxidase domain protein
IXO220_RS13155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO220_RS13165	COG0531	amino acid
IXO220_RS13170	COG0531	amino acid
IXO220_RS13175	COG0235	Class ii aldolase
IXO220_RS13180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO220_RS13210	COG2201	protein-glutamate methylesterase activity
IXO220_RS13260	COG0583	DNA-binding transcription factor activity
IXO220_RS13270	COG3039	Transposase
IXO220_RS13375	COG3039	Transposase
IXO220_RS13385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO220_RS13405	COG0557	exoribonuclease II activity
IXO220_RS13430	COG1960	acyl-CoA dehydrogenase activity
IXO220_RS13435	COG2226	methyltransferase
IXO220_RS13440	COG0646	methionine synthase
IXO220_RS13440	COG1410	methionine synthase
IXO220_RS13445	COG0646	methionine synthase
IXO220_RS13445	COG1410	methionine synthase
IXO220_RS13455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_RS13465	COG1609	Transcriptional regulator
IXO220_RS13480	COG2900	Belongs to the SlyX family
IXO220_RS13500	COG0386	Belongs to the glutathione peroxidase family
IXO220_RS13510	COG1725	Transcriptional regulator
IXO220_RS13515	COG1131	(ABC) transporter
IXO220_RS13575	COG2850	peptidyl-arginine hydroxylation
IXO220_RS13610	COG1132	(ABC) transporter
IXO220_RS13635	COG0287	Prephenate dehydrogenase
IXO220_RS13635	COG1605	Chorismate mutase
IXO220_RS13640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO220_RS13645	COG0484	heat shock protein binding
IXO220_RS13650	COG0443	Heat shock 70 kDa protein
IXO220_RS13655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO220_RS13665	COG0497	DNA recombination
IXO220_RS13675	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_RS13680	COG2914	Belongs to the UPF0125 (RnfH) family
IXO220_RS13690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO220_RS13705	COG1960	acyl-CoA dehydrogenase activity
IXO220_RS13715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO220_RS13770	COG2814	Major facilitator Superfamily
IXO220_RS13775	COG1566	PFAM secretion protein HlyD family protein
IXO220_RS13790	COG2207	Transcriptional regulator
IXO220_RS13815	COG4774	siderophore transport
IXO220_RS13825	COG0367	asparagine synthase
IXO220_RS13840	COG1393	Belongs to the ArsC family
IXO220_RS13855	COG3039	Transposase
IXO220_RS13905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO220_RS13920	COG0233	cytoplasmic translational termination
IXO220_RS13930	COG0575	Belongs to the CDS family
IXO220_RS13940	COG0750	zinc metalloprotease
IXO220_RS13960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO220_RS13965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO220_RS13985	COG0825	malonyl-CoA metabolic process
IXO220_RS13995	COG4771	TonB-dependent receptor
IXO220_RS14000	COG1131	(ABC) transporter
IXO220_RS14025	COG1981	membrane
IXO220_RS14070	COG0529	Catalyzes the synthesis of activated sulfate
IXO220_RS14070	COG2895	sulfate adenylyltransferase (ATP) activity
IXO220_RS14105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO220_RS14120	COG2040	homocysteine
IXO220_RS14125	COG0833	amino acid
IXO220_RS14145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO220_RS14145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO220_RS14155	COG2878	Part of a membrane complex involved in electron transport
IXO220_RS14170	COG1595	DNA-templated transcription, initiation
IXO220_RS14195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO220_RS14210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO220_RS14215	COG0251	oxidation-reduction process
IXO220_RS14225	COG0392	lysyltransferase activity
IXO220_RS14225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO220_RS14255	COG3039	Transposase
IXO220_RS14270	COG2814	Major facilitator Superfamily
IXO220_RS14275	COG1902	pentaerythritol trinitrate reductase activity
IXO220_RS14285	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO220_RS14300	COG1047	Peptidyl-prolyl cis-trans
IXO220_RS14340	COG3039	Transposase
IXO220_RS14345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO220_RS14360	COG1451	nucleotide metabolic process
IXO220_RS14380	COG0183	Belongs to the thiolase family
IXO220_RS14410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO220_RS14410	COG1793	dna ligase
IXO220_RS14420	COG1793	dna ligase
IXO220_RS14425	COG1201	RNA secondary structure unwinding
IXO220_RS14445	COG1278	Cold shock
IXO220_RS14450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO220_RS14455	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO220_RS14465	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO220_RS14475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO220_RS14500	COG3039	Transposase
IXO220_RS14510	COG2954	triphosphatase activity
IXO220_RS14525	COG1381	Involved in DNA repair and RecF pathway recombination
IXO220_RS14555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO220_RS14570	COG1024	Enoyl-CoA hydratase
IXO220_RS14570	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO220_RS14590	COG1024	Enoyl-CoA hydratase
IXO220_RS14595	COG1960	acyl-CoA dehydrogenase activity
IXO220_RS14665	COG2353	YceI-like domain
IXO220_RS14675	COG2353	YceI-like domain
IXO220_RS14690	COG1760	l-serine dehydratase
IXO220_RS14700	COG0626	cystathionine gamma-synthase activity
IXO220_RS14705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO220_RS14710	COG0739	heme binding
IXO220_RS14720	COG1272	protein, Hemolysin III
IXO220_RS14745	COG0463	Glycosyl transferase, family 2
IXO220_RS14755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO220_RS14765	COG4771	TonB-dependent receptor
IXO220_RS14770	COG1309	transcriptional regulator
IXO220_RS14780	COG1960	acyl-CoA dehydrogenase activity
IXO220_RS14810	COG0509	glycine decarboxylation via glycine cleavage system
IXO220_RS14825	COG0330	HflC and HflK could
IXO220_RS14840	COG3956	TIGRFAM MazG family protein
IXO220_RS14850	COG0494	nUDIX hydrolase
IXO220_RS14860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO220_RS14865	COG0837	glucose binding
IXO220_RS14880	COG1388	LysM domain
IXO220_RS14880	COG3858	chitin binding
IXO220_RS14885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO220_RS14895	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO220_RS14955	COG3537	Alpha-1,2-mannosidase
IXO220_RS14995	COG3142	Participates in the control of copper homeostasis
IXO220_RS15000	COG1446	asparaginase
IXO220_RS15010	COG2304	oxidoreductase activity
IXO220_RS15015	COG2304	oxidoreductase activity
IXO220_RS15055	COG0643	Histidine kinase
IXO220_RS15055	COG0784	Response regulator, receiver
IXO220_RS15055	COG2198	Histidine kinase
IXO220_RS15060	COG0840	transmembrane signaling receptor activity
IXO220_RS15065	COG0835	chemotaxis
IXO220_RS15080	COG0189	ligase activity
IXO220_RS15090	COG1397	ADP-ribosylglycohydrolase
IXO220_RS15100	COG1199	ATP-dependent helicase activity
IXO220_RS15110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO220_RS15115	COG1215	transferase activity, transferring glycosyl groups
IXO220_RS15125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO220_RS15145	COG0535	radical SAM domain protein
IXO220_RS15150	COG0535	radical SAM domain protein
IXO220_RS15185	COG1643	Atp-dependent helicase
IXO220_RS15190	COG0783	Belongs to the Dps family
IXO220_RS15195	COG0514	ATP-dependent DNA helicase (RecQ)
IXO220_RS15220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO220_RS15275	COG1187	pseudouridine synthase activity
IXO220_RS15280	COG0602	queuosine metabolic process
IXO220_RS15290	COG2885	chlorophyll binding
IXO220_RS15305	COG0848	biopolymer transport protein
IXO220_RS15315	COG0824	Thioesterase
IXO220_RS15320	COG2255	four-way junction helicase activity
IXO220_RS15330	COG0632	four-way junction helicase activity
IXO220_RS15460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO220_RS15465	COG1845	cytochrome c oxidase, subunit III
IXO220_RS15470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO220_RS15485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO220_RS15490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO220_RS15500	COG0196	riboflavin kinase activity
IXO220_RS15505	COG0728	peptidoglycan biosynthetic process
IXO220_RS15510	COG0268	Binds directly to 16S ribosomal RNA
IXO220_RS15515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO220_RS15520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO220_RS15530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO220_RS15535	COG0824	Thioesterase
IXO220_RS15550	COG1946	Acyl-CoA thioesterase
IXO220_RS15575	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO220_RS15610	COG1877	trehalose-phosphatase activity
IXO220_RS15615	COG3387	PFAM Glycoside hydrolase 15-related
IXO220_RS15640	COG0564	pseudouridine synthase activity
IXO220_RS15645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_RS15650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO220_RS15650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO220_RS15660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO220_RS15665	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO220_RS15690	COG2184	nucleotidyltransferase activity
IXO220_RS15710	COG2194	sulfuric ester hydrolase activity
IXO220_RS15715	COG4969	Belongs to the N-Me-Phe pilin family
IXO220_RS15725	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO220_RS15745	COG3039	Transposase
IXO220_RS15765	COG3039	Transposase
IXO220_RS15800	COG1132	(ABC) transporter
IXO220_RS15830	COG0745	RESPONSE REGULATOR receiver
IXO220_RS15835	COG5000	phosphorelay sensor kinase activity
IXO220_RS15835	COG5002	protein histidine kinase activity
IXO220_RS15840	COG0475	glutathione-regulated potassium exporter activity
IXO220_RS15850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO220_RS15870	COG1187	pseudouridine synthase activity
IXO220_RS15875	COG5002	protein histidine kinase activity
IXO220_RS15875	COG5001	Diguanylate cyclase
IXO220_RS15995	COG0415	Belongs to the DNA photolyase family
IXO220_RS16000	COG0305	Participates in initiation and elongation during chromosome replication
IXO220_RS16010	COG0367	asparagine synthase
IXO220_RS16025	COG1960	acyl-CoA dehydrogenase activity
IXO220_RS16040	COG0084	hydrolase, TatD family'
IXO220_RS16045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO220_RS16105	COG0735	belongs to the Fur family
IXO220_RS16110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO220_RS16125	COG3039	Transposase
IXO220_RS16215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO220_RS16225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO220_RS16240	COG2198	Histidine kinase
IXO220_RS16240	COG0643	Histidine kinase
IXO220_RS16245	COG0840	transmembrane signaling receptor activity
IXO220_RS16250	COG0835	chemotaxis
IXO220_RS16255	COG2199	diguanylate cyclase activity
IXO220_RS16255	COG2200	EAL domain
IXO220_RS16255	COG2202	Pas domain
IXO220_RS16260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO220_RS16275	COG3590	peptidase
IXO220_RS16290	COG0588	phosphoglycerate mutase activity
IXO220_RS16295	COG1515	deoxyribonuclease V activity
IXO220_RS16305	COG1741	Belongs to the pirin family
IXO220_RS16370	COG1741	Belongs to the pirin family
IXO220_RS16375	COG1966	Carbon starvation protein
IXO220_RS16380	COG2879	small protein
IXO220_RS16420	COG4251	negative regulation of phosphorylation
IXO220_RS16420	COG5001	Diguanylate cyclase
IXO220_RS16420	COG3706	GGDEF domain
IXO220_RS16420	COG2203	Gaf domain
IXO220_RS16425	COG0629	single-stranded DNA binding
IXO220_RS16430	COG0142	geranyltranstransferase activity
IXO220_RS16455	COG0527	aspartate kinase activity
IXO220_RS16465	COG0384	phenazine biosynthesis protein PhzF
IXO220_RS16475	COG1764	response to oxidative stress
IXO220_RS16490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO220_RS16495	COG1678	Uncharacterized ACR, COG1678
IXO220_RS16510	COG0519	Catalyzes the synthesis of GMP from XMP
IXO220_RS16540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO220_RS16600	COG1959	2 iron, 2 sulfur cluster binding
IXO220_RS16605	COG0719	Fe-S assembly protein
IXO220_RS16610	COG0396	ATPase activity
IXO220_RS16615	COG0719	Fe-S assembly protein
IXO220_RS16620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO220_RS16630	COG2146	nitrite reductase [NAD(P)H] activity
IXO220_RS16655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO220_RS16670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO220_RS16680	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO220_RS16685	COG0174	glutamine synthetase
IXO220_RS16690	COG3328	transposase activity
IXO220_RS16715	COG0326	Molecular chaperone. Has ATPase activity
IXO220_RS16720	COG2207	Transcriptional regulator
IXO220_RS16745	COG0657	acetylesterase activity
IXO220_RS16745	COG2755	lipolytic protein G-D-S-L family
IXO220_RS16770	COG0488	(ABC) transporter
IXO220_RS16805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO220_RS16805	COG4651	solute:proton antiporter activity
IXO220_RS16830	COG4772	TonB-dependent receptor
IXO220_RS16840	COG4264	IucA IucC family
IXO220_RS16845	COG2814	Major facilitator Superfamily
IXO220_RS16855	COG0019	diaminopimelate decarboxylase activity
IXO220_RS16920	COG4206	TonB-dependent receptor
IXO220_RS16955	COG0542	response to heat
IXO220_RS16995	COG0534	Mate efflux family protein
IXO220_RS17015	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO220_RS17020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO220_RS17025	COG0228	four-way junction DNA binding
IXO220_RS17045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO220_RS17055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO220_RS17100	COG1555	photosystem II stabilization
IXO220_RS17105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO220_RS17120	COG3178	'Phosphotransferase
IXO220_RS17125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO220_RS17135	COG0628	permease
IXO220_RS17145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO220_RS17160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO220_RS17180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO220_RS17185	COG0271	Belongs to the BolA IbaG family
IXO220_RS17195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO220_RS17205	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO220_RS17210	COG1137	ATPase activity
IXO220_RS17225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO220_RS17230	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO220_RS17235	COG1660	Displays ATPase and GTPase activities
IXO220_RS17250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO220_RS17255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO220_RS17260	COG2239	Acts as a magnesium transporter
IXO220_RS17270	COG1294	oxidase, subunit
IXO220_RS17275	COG1271	oxidase subunit
IXO220_RS17290	COG1113	amino acid transport
IXO220_RS17305	COG2197	response regulator
IXO220_RS17310	COG0531	amino acid
IXO220_RS17370	COG0754	glutathionylspermidine amidase activity
IXO220_RS17395	COG1842	Phage shock protein A
IXO220_RS17410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO220_RS17415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO220_RS17425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO220_RS17455	COG2201	protein-glutamate methylesterase activity
IXO220_RS17505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO220_RS17555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO220_RS17560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO220_RS17590	COG3039	Transposase
IXO220_RS17605	COG0745	RESPONSE REGULATOR receiver
IXO220_RS17610	COG2205	protein histidine kinase activity
IXO220_RS17630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO220_RS17660	COG3453	Protein conserved in bacteria
IXO220_RS17660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO220_RS17665	COG3039	Transposase
IXO220_RS17670	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO220_RS17675	COG4149	molybdate abc transporter
IXO220_RS17680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO220_RS17700	COG0642	Histidine kinase
IXO220_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS17725	COG1022	Amp-dependent synthetase and ligase
IXO220_RS17750	COG1376	ErfK ybiS ycfS ynhG family protein
IXO220_RS17755	COG0739	heme binding
IXO220_RS17765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO220_RS17770	COG1301	dicarboxylic acid transport
IXO220_RS17790	COG2304	oxidoreductase activity
IXO220_RS17810	COG0714	Associated with various cellular activities
IXO220_RS17855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO220_RS17880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO220_RS17890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO220_RS17915	COG1561	YicC-like family, N-terminal region
IXO220_RS17920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO220_RS17935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO220_RS17970	COG0006	proline dipeptidase activity
IXO220_RS17995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO220_RS18005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO220_RS18015	COG2912	Transglutaminase-like superfamily
IXO220_RS18020	COG1773	rubredoxin
IXO220_RS18025	COG0352	thiamine-phosphate diphosphorylase activity
IXO220_RS18090	COG0280	phosphate acetyltransferase
IXO220_RS18090	COG0281	malic enzyme
IXO220_RS18110	COG4191	Histidine kinase
IXO220_RS18125	COG0583	DNA-binding transcription factor activity
IXO220_RS18145	COG2197	response regulator
IXO220_RS18155	COG0642	Histidine kinase
IXO220_RS18170	COG2851	Citrate transporter
IXO220_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS18180	COG1609	Transcriptional regulator
IXO220_RS18190	COG2211	Major facilitator Superfamily
IXO220_RS18215	COG1162	GTPase activity
IXO220_RS18240	COG0726	polysaccharide deacetylase
IXO220_RS18245	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO220_RS18270	COG3039	Transposase
IXO220_RS18275	COG3039	Transposase
IXO220_RS18320	COG0242	peptide deformylase activity
IXO220_RS18340	COG0714	Associated with various cellular activities
IXO220_RS18360	COG0537	adenosine 5'-monophosphoramidase activity
IXO220_RS18390	COG0314	molybdopterin synthase activity
IXO220_RS18395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO220_RS18400	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO220_RS18410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO220_RS18415	COG1234	tRNA 3'-trailer cleavage
IXO220_RS18420	COG3642	lipopolysaccharide core region biosynthetic process
IXO220_RS18425	COG0859	PFAM glycosyl transferase family 9
IXO220_RS18435	COG0582	viral genome integration into host DNA
IXO220_RS18495	COG0631	protein serine/threonine phosphatase activity
IXO220_RS18505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO220_RS18530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO220_RS18570	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO220_RS18620	COG0473	3-isopropylmalate dehydrogenase activity
IXO220_RS18645	COG4783	chaperone-mediated protein folding
IXO220_RS18660	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO220_RS18670	COG0438	transferase activity, transferring glycosyl groups
IXO220_RS18675	COG0671	phosphoesterase, PA-phosphatase related
IXO220_RS18680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO220_RS18700	COG2833	Protein of unknown function (DUF455)
IXO220_RS18720	COG0285	dihydrofolate synthase activity
IXO220_RS18730	COG0588	phosphoglycerate mutase activity
IXO220_RS18760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO220_RS18765	COG4208	sulfate ABC transporter
IXO220_RS18770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO220_RS18775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO220_RS18780	COG0156	8-amino-7-oxononanoate synthase activity
IXO220_RS18805	COG0604	alcohol dehydrogenase
IXO220_RS18810	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO220_RS18810	COG1902	pentaerythritol trinitrate reductase activity
IXO220_RS18935	COG3386	PFAM SMP-30 Gluconolaconase
IXO220_RS18955	COG1024	Enoyl-CoA hydratase
IXO220_RS18965	COG0318	PFAM AMP-dependent synthetase and ligase
IXO220_RS18970	COG0583	DNA-binding transcription factor activity
IXO220_RS19010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO220_RS19015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO220_RS19025	COG2096	Adenosyltransferase
IXO220_RS19030	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO220_RS19045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO220_RS19055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO220_RS19060	COG2967	ApaG domain
IXO220_RS19085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO220_RS19105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO220_RS19125	COG0642	Histidine kinase
IXO220_RS19140	COG4181	ATPase activity
IXO220_RS19150	COG2175	clavaminate synthase activity
IXO220_RS19205	COG0667	Aldo Keto reductase
IXO220_RS19215	COG3039	Transposase
IXO220_RS19225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO220_RS19230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_RS19240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO220_RS19255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO220_RS19300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO220_RS19305	COG2226	methyltransferase
IXO220_RS19350	COG3321	synthase
IXO220_RS19350	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS19350	COG0604	alcohol dehydrogenase
IXO220_RS19360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO220_RS19375	COG0494	nUDIX hydrolase
IXO220_RS19390	COG4942	peptidase
IXO220_RS19390	COG1388	LysM domain
IXO220_RS19400	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO220_RS19415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO220_RS19420	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO220_RS19425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO220_RS19440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO220_RS19445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO220_RS19460	COG3116	cell division
IXO220_RS19465	COG0275	rRNA processing
IXO220_RS19500	COG0792	nuclease activity
IXO220_RS19505	COG1988	membrane-bound metal-dependent
IXO220_RS19510	COG0277	FAD linked oxidase domain protein
IXO220_RS19515	COG0745	RESPONSE REGULATOR receiver
IXO220_RS19520	COG2205	protein histidine kinase activity
IXO220_RS19530	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO220_RS19535	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO220_RS19555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO220_RS19560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO220_RS19565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO220_RS19585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO220_RS19585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO220_RS19605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO220_RS19625	COG0488	(ABC) transporter
IXO220_RS19635	COG3039	Transposase
IXO220_RS19655	COG3791	Glutathione-dependent formaldehyde-activating
IXO220_RS19685	COG2205	protein histidine kinase activity
IXO220_RS19745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO220_RS19780	COG3039	Transposase
IXO220_RS19805	COG3039	Transposase
IXO220_RS19885	COG1649	PFAM Uncharacterised BCR, COG1649
IXO220_RS19885	COG0726	polysaccharide deacetylase
IXO220_RS19890	COG1215	transferase activity, transferring glycosyl groups
IXO220_RS19900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO220_RS19905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO220_RS19910	COG1609	Transcriptional regulator
IXO220_RS19920	COG2188	Transcriptional regulator
IXO220_RS19935	COG3250	beta-galactosidase activity
IXO220_RS19985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO220_RS19990	COG4191	Histidine kinase
IXO220_RS19995	COG0784	Response regulator, receiver
IXO220_RS20000	COG4251	negative regulation of phosphorylation
IXO220_RS20005	COG2823	Periplasmic or secreted lipoprotein
IXO220_RS20010	COG0673	inositol 2-dehydrogenase activity
IXO220_RS20015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO220_RS20050	COG1056	cytidyltransferase-related domain
IXO220_RS20050	COG1051	belongs to the nudix hydrolase family
IXO220_RS20075	COG2921	Belongs to the UPF0250 family
IXO220_RS20090	COG1686	Belongs to the peptidase S11 family
IXO220_RS20095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO220_RS20100	COG2951	lytic endotransglycosylase activity
IXO220_RS20170	COG0772	Belongs to the SEDS family
IXO220_RS20185	COG1792	Involved in formation and maintenance of cell shape
IXO220_RS20190	COG1077	Cell shape determining protein MreB Mrl
IXO220_RS20195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_RS20245	COG2199	diguanylate cyclase activity
IXO220_RS20250	COG0308	aminopeptidase N
IXO220_RS20280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO220_RS20310	COG0436	Aminotransferase
IXO220_RS20315	COG3039	Transposase
IXO220_RS20335	COG1505	serine-type exopeptidase activity
IXO220_RS20360	COG0181	hydroxymethylbilane synthase activity
IXO220_RS20370	COG3275	phosphorelay sensor kinase activity
IXO220_RS20405	COG0659	secondary active sulfate transmembrane transporter activity
IXO220_RS20410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_RS20410	COG5297	Belongs to the glycosyl hydrolase family 6
IXO220_RS20485	COG0598	Magnesium transport protein CorA
IXO220_RS20495	COG1113	amino acid transport
IXO220_RS20505	COG5297	Belongs to the glycosyl hydrolase family 6
IXO220_RS20510	COG4305	rare lipoprotein A
IXO220_RS20515	COG0697	spore germination
IXO220_RS20575	COG4221	oxidoreductase activity
IXO220_RS20605	COG0456	acetyltransferase
IXO220_RS20615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO220_RS20655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO220_RS20655	COG2111	Na H antiporter
IXO220_RS20660	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO220_RS20665	COG0651	ATP synthesis coupled electron transport
IXO220_RS20675	COG2212	antiporter activity
IXO220_RS20680	COG1320	monovalent cation:proton antiporter activity
IXO220_RS20690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO220_RS20710	COG3104	oligopeptide transport
IXO220_RS20715	COG3483	tryptophan 2,3-dioxygenase activity
IXO220_RS20765	COG0183	Belongs to the thiolase family
IXO220_RS20835	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO220_RS20840	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO220_RS20850	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_RS20875	COG0531	amino acid
IXO220_RS20905	COG4682	membrane
IXO220_RS20910	COG2133	pyrroloquinoline quinone binding
IXO220_RS20950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO220_RS20955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO220_RS20965	COG1610	YqeY-like protein
IXO220_RS20975	COG1295	ribonuclease BN
IXO220_RS20980	COG0358	DNA primase activity
IXO220_RS21045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO220_RS21060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO220_RS21110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO220_RS21115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO220_RS21120	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO220_RS21130	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO220_RS21135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO220_RS21145	COG0134	indole-3-glycerol-phosphate synthase activity
IXO220_RS21150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO220_RS21235	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO220_RS21235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO220_RS21245	COG1473	amidohydrolase
IXO220_RS21250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_RS21255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO220_RS21265	COG5383	Protein conserved in bacteria
IXO220_RS21300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO220_RS21305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO220_RS21320	COG0028	Belongs to the TPP enzyme family
IXO220_RS21325	COG4191	Histidine kinase
IXO220_RS21350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO220_RS21365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO220_RS21370	COG3177	Filamentation induced by cAMP protein fic
IXO220_RS21385	COG0596	Alpha beta hydrolase
IXO220_RS21390	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO220_RS21395	COG0318	PFAM AMP-dependent synthetase and ligase
IXO220_RS21400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO220_RS21450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO220_RS21460	COG0129	dihydroxy-acid dehydratase activity
IXO220_RS21480	COG3039	Transposase
IXO220_RS21490	COG0408	coproporphyrinogen oxidase activity
IXO220_RS21530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO220_RS21590	COG2353	YceI-like domain
IXO220_RS21595	COG0778	Nitroreductase
IXO220_RS21645	COG3386	PFAM SMP-30 Gluconolaconase
IXO220_RS21670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO220_RS21690	COG0459	protein refolding
IXO220_RS21715	COG1252	NADH dehydrogenase
IXO220_RS21725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO220_RS21730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO220_RS21735	COG2201	protein-glutamate methylesterase activity
IXO220_RS21740	COG2177	Part of the ABC transporter FtsEX involved in
IXO220_RS21745	COG2884	Cell division ATP-binding protein ftsE
IXO220_RS21755	COG3118	belongs to the thioredoxin family
IXO220_RS21760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO220_RS21775	COG0729	surface antigen
IXO220_RS21780	COG2911	Protein conserved in bacteria
IXO220_RS21830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO220_RS21880	COG1733	regulation of RNA biosynthetic process
IXO220_RS21885	COG0702	epimerase
IXO220_RS21915	COG0583	DNA-binding transcription factor activity
IXO220_RS21920	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO220_RS21940	COG0745	RESPONSE REGULATOR receiver
IXO220_RS21970	COG1902	pentaerythritol trinitrate reductase activity
IXO220_RS21975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO220_RS21985	COG2814	Major facilitator Superfamily
IXO220_RS21990	COG0583	DNA-binding transcription factor activity
IXO220_RS22005	COG0084	hydrolase, TatD family'
IXO220_RS22050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO220_RS22075	COG2351	hydroxyisourate hydrolase activity
IXO220_RS22135	COG4770	biotin carboxylase activity
IXO220_RS22140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO220_RS22145	COG1960	acyl-CoA dehydrogenase activity
IXO220_RS22195	COG0523	cobalamin synthesis protein
IXO220_RS22215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO220_RS22235	COG4771	TonB-dependent receptor
IXO220_RS22240	COG0457	Tetratricopeptide repeat
IXO220_RS22250	COG0752	glycyl-tRNA synthetase alpha subunit
IXO220_RS22255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO220_RS22270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO220_RS22270	COG0519	Catalyzes the synthesis of GMP from XMP
IXO220_RS22280	COG0805	protein transport
IXO220_RS22290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO220_RS22300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO220_RS22325	COG2974	May be involved in recombination
IXO220_RS22330	COG0037	tRNA processing
IXO220_RS22350	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO220_RS22360	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_RS22370	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO220_RS22375	COG0246	Mannitol dehydrogenase
IXO220_RS22400	COG3693	PFAM glycoside hydrolase, family 10
IXO220_RS22425	COG2211	Major facilitator Superfamily
IXO220_RS22510	COG1846	Transcriptional regulator
IXO220_RS22515	COG1764	response to oxidative stress
IXO220_RS22595	COG3549	Plasmid maintenance system killer
IXO220_RS22605	COG1074	ATP-dependent DNA helicase activity
IXO220_RS22610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO220_RS22625	COG1196	nuclear chromosome segregation
IXO220_RS22660	COG2032	superoxide dismutase activity
IXO220_RS22665	COG2032	superoxide dismutase activity
IXO220_RS22670	COG2204	response regulator
IXO220_RS22675	COG3852	Histidine kinase
IXO220_RS22680	COG0004	ammonium transporteR
IXO220_RS22685	COG0347	Belongs to the P(II) protein family
IXO220_RS22690	COG0174	glutamine synthetase
IXO220_RS22695	COG1968	undecaprenyl-diphosphatase activity
IXO220_RS22735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO220_RS22745	COG2062	phosphohistidine phosphatase, SixA
IXO220_RS22750	COG0489	protein tyrosine kinase activity
IXO220_RS22770	COG1396	sequence-specific DNA binding
IXO220_RS22775	COG3550	peptidyl-serine autophosphorylation
IXO220_RS22780	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO220_RS22785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO220_RS22800	COG0517	IMP dehydrogenase activity
IXO220_RS22800	COG1125	glycine betaine transport
IXO220_RS22815	COG1119	ATPase activity
IXO220_RS22825	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO220_RS22840	COG3039	Transposase
IXO220_RS22865	COG0656	L-ascorbic acid biosynthetic process
IXO220_RS22870	COG2130	NADP-dependent
IXO220_RS22875	COG0667	Aldo Keto reductase
IXO220_RS22885	COG1187	pseudouridine synthase activity
IXO220_RS22895	COG1643	Atp-dependent helicase
IXO220_RS22900	COG4807	Protein conserved in bacteria
IXO220_RS22905	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_RS22910	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO220_RS22915	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_RS22975	COG3162	membrane
IXO220_RS22980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO220_RS22995	COG0708	Exodeoxyribonuclease III
IXO220_RS23010	COG2091	lysine biosynthetic process via aminoadipic acid
IXO220_RS23020	COG3540	Alkaline phosphatase
IXO220_RS23025	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO220_RS23045	COG2159	amidohydrolase
IXO220_RS23055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO220_RS23060	COG0583	DNA-binding transcription factor activity
IXO220_RS23065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO220_RS23080	COG0210	DNA helicase
IXO220_RS23095	COG0531	amino acid
IXO220_RS23105	COG1322	Protein conserved in bacteria
IXO220_RS23115	COG0386	Belongs to the glutathione peroxidase family
IXO220_RS23170	COG0793	Belongs to the peptidase S41A family
IXO220_RS23175	COG4942	peptidase
IXO220_RS23185	COG2234	aminopeptidase activity
IXO220_RS23230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO220_RS23235	COG0302	gtp cyclohydrolase
IXO220_RS23255	COG0477	Major facilitator Superfamily
IXO220_RS23335	COG1929	Belongs to the glycerate kinase type-1 family
IXO220_RS23340	COG2271	Major facilitator Superfamily
IXO220_RS23355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO220_RS23360	COG0861	Integral membrane protein TerC family
IXO220_RS23375	COG0584	glycerophosphoryl diester phosphodiesterase
IXO220_RS23385	COG0671	phosphoesterase, PA-phosphatase related
IXO220_RS23390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO220_RS23395	COG0726	polysaccharide deacetylase