locus-tag	class	description
IXO221_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO221_RS00020	COG0187	DNA topoisomerase II activity
IXO221_RS00030	COG0501	Belongs to the peptidase M48B family
IXO221_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO221_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO221_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO221_RS00095	COG4772	TonB-dependent receptor
IXO221_RS00110	COG3039	Transposase
IXO221_RS00115	COG1304	FMN binding
IXO221_RS00135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO221_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO221_RS00215	COG3039	Transposase
IXO221_RS00235	COG2826	transposase and inactivated derivatives, IS30 family
IXO221_RS00270	COG1090	epimerase
IXO221_RS00290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO221_RS00400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO221_RS00475	COG3264	Mechanosensitive ion channel
IXO221_RS00475	COG1511	domain protein
IXO221_RS00490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO221_RS00495	COG2354	Protein conserved in bacteria
IXO221_RS00500	COG1649	PFAM Uncharacterised BCR, COG1649
IXO221_RS00520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO221_RS00545	COG0702	epimerase
IXO221_RS00560	COG1858	cytochrome C peroxidase
IXO221_RS00640	COG0513	Belongs to the DEAD box helicase family
IXO221_RS00645	COG3039	Transposase
IXO221_RS00690	COG1136	(ABC) transporter
IXO221_RS00725	COG1136	(ABC) transporter
IXO221_RS00765	COG1272	protein, Hemolysin III
IXO221_RS00770	COG1111	helicase
IXO221_RS00770	COG1205	dead DEAH box helicase
IXO221_RS00830	COG0067	glutamate synthase
IXO221_RS00830	COG0069	glutamate synthase activity
IXO221_RS00830	COG0070	glutamate synthase
IXO221_RS00835	COG0493	'glutamate synthase
IXO221_RS00880	COG1609	Transcriptional regulator
IXO221_RS00905	COG0366	Alpha amylase catalytic
IXO221_RS00910	COG0366	Alpha amylase catalytic
IXO221_RS00955	COG0606	chelatase, subunit chli
IXO221_RS00995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO221_RS01000	COG1166	arginine decarboxylase activity
IXO221_RS01060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO221_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS01110	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO221_RS01130	COG0210	DNA helicase
IXO221_RS01145	COG3132	Protein of unknown function, DUF480
IXO221_RS01150	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO221_RS01155	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO221_RS01190	COG2937	Belongs to the GPAT DAPAT family
IXO221_RS01230	COG3186	Phenylalanine-4-hydroxylase
IXO221_RS01235	COG1522	sequence-specific DNA binding
IXO221_RS01280	COG1064	alcohol dehydrogenase
IXO221_RS01285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO221_RS01295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO221_RS01305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO221_RS01325	COG0676	glucose-6-phosphate 1-epimerase activity
IXO221_RS01390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO221_RS01415	COG2853	Lipoprotein
IXO221_RS01430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO221_RS01435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO221_RS01440	COG1127	ABC transporter
IXO221_RS01515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO221_RS01525	COG3039	Transposase
IXO221_RS01530	COG3265	gluconokinase activity
IXO221_RS01535	COG2211	Major facilitator Superfamily
IXO221_RS01540	COG3459	Glycosyltransferase 36 associated
IXO221_RS01550	COG2205	protein histidine kinase activity
IXO221_RS01565	COG1414	Transcriptional regulator
IXO221_RS01570	COG0738	Major facilitator superfamily
IXO221_RS01575	COG3254	rhamnose metabolic process
IXO221_RS01605	COG0339	signal peptide processing
IXO221_RS01635	COG0564	pseudouridine synthase activity
IXO221_RS01645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO221_RS01655	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO221_RS01720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO221_RS01730	COG0842	Transport permease protein
IXO221_RS01735	COG1131	(ABC) transporter
IXO221_RS01765	COG1476	TRANSCRIPTIONal
IXO221_RS01775	COG4555	ABC transporter
IXO221_RS01815	COG0625	glutathione transferase activity
IXO221_RS01860	COG0583	DNA-binding transcription factor activity
IXO221_RS01900	COG1199	ATP-dependent helicase activity
IXO221_RS01935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO221_RS01965	COG3228	Belongs to the MtfA family
IXO221_RS01975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO221_RS01975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO221_RS01980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO221_RS01995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO221_RS02030	COG3237	CsbD-like
IXO221_RS02035	COG0180	Tryptophanyl-tRNA synthetase
IXO221_RS02040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO221_RS02085	COG0753	catalase activity
IXO221_RS02100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO221_RS02110	COG0628	permease
IXO221_RS02120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO221_RS02125	COG1040	competence protein
IXO221_RS02130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO221_RS02135	COG0156	8-amino-7-oxononanoate synthase activity
IXO221_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS02160	COG0463	Glycosyl transferase, family 2
IXO221_RS02170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO221_RS02175	COG3100	YcgL domain-containing protein
IXO221_RS02190	COG3387	PFAM Glycoside hydrolase 15-related
IXO221_RS02195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO221_RS02210	COG2239	Acts as a magnesium transporter
IXO221_RS02220	COG1042	CoA-binding domain protein
IXO221_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO221_RS02220	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO221_RS02230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO221_RS02235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO221_RS02270	COG3485	protocatechuate 3,4-dioxygenase
IXO221_RS02290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO221_RS02295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO221_RS02320	COG4221	oxidoreductase activity
IXO221_RS02345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO221_RS02370	COG0463	Glycosyl transferase, family 2
IXO221_RS02385	COG1475	DNA binding
IXO221_RS02390	COG1192	Involved in chromosome partitioning
IXO221_RS02405	COG0708	Exodeoxyribonuclease III
IXO221_RS02410	COG2211	Major facilitator Superfamily
IXO221_RS02425	COG0739	heme binding
IXO221_RS02470	COG0745	RESPONSE REGULATOR receiver
IXO221_RS02505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO221_RS02520	COG2814	Major facilitator Superfamily
IXO221_RS02535	COG1289	transmembrane transporter activity
IXO221_RS02555	COG0577	efflux transmembrane transporter activity
IXO221_RS02555	COG1136	(ABC) transporter
IXO221_RS02560	COG0151	Belongs to the GarS family
IXO221_RS02570	COG0138	bifunctional purine biosynthesis protein purh
IXO221_RS02600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO221_RS02640	COG0439	Biotin carboxylase
IXO221_RS02650	COG0511	ligase activity, forming carbon-carbon bonds
IXO221_RS02655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO221_RS02665	COG1324	tolerance protein
IXO221_RS02700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO221_RS02720	COG0534	Mate efflux family protein
IXO221_RS02725	COG0616	signal peptide processing
IXO221_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS02750	COG0009	L-threonylcarbamoyladenylate synthase
IXO221_RS02755	COG1754	DNA topoisomerase type I activity
IXO221_RS02755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO221_RS02770	COG2922	Belongs to the Smg family
IXO221_RS02775	COG0758	DNA mediated transformation
IXO221_RS02780	COG1652	LysM domain
IXO221_RS02785	COG0242	peptide deformylase activity
IXO221_RS02790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO221_RS02855	COG1560	Kdo2-lipid A biosynthetic process
IXO221_RS02865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO221_RS03015	COG3039	Transposase
IXO221_RS03025	COG1271	oxidase subunit
IXO221_RS03090	COG0531	amino acid
IXO221_RS03110	COG3590	peptidase
IXO221_RS03120	COG0667	Aldo Keto reductase
IXO221_RS03135	COG3384	dioxygenase
IXO221_RS03145	COG1573	uracil-dna glycosylase
IXO221_RS03155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO221_RS03165	COG0025	NhaP-type Na H and K H
IXO221_RS03170	COG1131	(ABC) transporter
IXO221_RS03175	COG0842	Transport permease protein
IXO221_RS03190	COG1404	Belongs to the peptidase S8 family
IXO221_RS03205	COG0745	RESPONSE REGULATOR receiver
IXO221_RS03255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO221_RS03280	COG2202	Pas domain
IXO221_RS03280	COG2205	protein histidine kinase activity
IXO221_RS03310	COG2813	Specifically methylates the guanine in position
IXO221_RS03315	COG1187	pseudouridine synthase activity
IXO221_RS03320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO221_RS03355	COG0697	spore germination
IXO221_RS03365	COG2011	ABC-type metal ion transport system permease component
IXO221_RS03395	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO221_RS03405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO221_RS03425	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO221_RS03435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO221_RS03445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO221_RS03450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO221_RS03455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO221_RS03460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO221_RS03510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO221_RS03515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO221_RS03565	COG0339	signal peptide processing
IXO221_RS03600	COG1956	GAF domain-containing protein
IXO221_RS03605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO221_RS03615	COG0720	synthase
IXO221_RS03620	COG0513	Belongs to the DEAD box helicase family
IXO221_RS03630	COG0625	glutathione transferase activity
IXO221_RS03660	COG0626	cystathionine gamma-synthase activity
IXO221_RS03700	COG3328	transposase activity
IXO221_RS03725	COG2086	electron transfer activity
IXO221_RS03750	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO221_RS03750	COG0662	Cupin 2, conserved barrel domain protein
IXO221_RS03755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO221_RS03790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO221_RS03790	COG3218	ABC-type transport auxiliary lipoprotein component
IXO221_RS03795	COG1127	ABC transporter
IXO221_RS03800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO221_RS03820	COG0442	prolyl-tRNA aminoacylation
IXO221_RS03830	COG1183	phosphatidylcholine synthase activity
IXO221_RS03860	COG3039	Transposase
IXO221_RS03895	COG3039	Transposase
IXO221_RS03925	COG0525	valine-tRNA ligase activity
IXO221_RS03940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO221_RS03950	COG0795	lipopolysaccharide-transporting ATPase activity
IXO221_RS03965	COG4974	Belongs to the 'phage' integrase family
IXO221_RS03970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO221_RS03975	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO221_RS03975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO221_RS03980	COG5295	Hep Hag repeat protein
IXO221_RS03990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO221_RS04000	COG1459	type II secretion system
IXO221_RS04005	COG2165	general secretion pathway protein
IXO221_RS04010	COG4970	Tfp pilus assembly protein FimT
IXO221_RS04015	COG2165	general secretion pathway protein
IXO221_RS04020	COG4795	General secretion pathway protein
IXO221_RS04025	COG3156	type II secretion system protein K
IXO221_RS04030	COG3166	PFAM Fimbrial assembly family protein
IXO221_RS04045	COG1450	Type ii and iii secretion system protein
IXO221_RS04060	COG2188	Transcriptional regulator
IXO221_RS04105	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO221_RS04110	COG1518	maintenance of DNA repeat elements
IXO221_RS04145	COG3039	Transposase
IXO221_RS04160	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO221_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS04190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO221_RS04200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO221_RS04205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO221_RS04225	COG3039	Transposase
IXO221_RS04245	COG3829	transcription factor binding
IXO221_RS04325	COG2826	transposase and inactivated derivatives, IS30 family
IXO221_RS04335	COG0678	peroxiredoxin activity
IXO221_RS04355	COG0330	HflC and HflK could
IXO221_RS04360	COG0330	HflC and HflK could
IXO221_RS04370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO221_RS04375	COG0308	aminopeptidase N
IXO221_RS04435	COG1560	Kdo2-lipid A biosynthetic process
IXO221_RS04440	COG1519	Transferase
IXO221_RS04445	COG1538	Outer membrane efflux protein
IXO221_RS04450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO221_RS04480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO221_RS04485	COG0066	3-isopropylmalate dehydratase activity
IXO221_RS04490	COG2226	methyltransferase
IXO221_RS04520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO221_RS04530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO221_RS04535	COG3710	Transcriptional regulator
IXO221_RS04560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO221_RS04580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO221_RS04615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO221_RS04625	COG3781	membrane
IXO221_RS04760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO221_RS04780	COG1217	gtp-binding protein TYPA
IXO221_RS04785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO221_RS04790	COG0039	L-malate dehydrogenase activity
IXO221_RS04795	COG0625	glutathione transferase activity
IXO221_RS04810	COG3039	Transposase
IXO221_RS04845	COG0584	glycerophosphoryl diester phosphodiesterase
IXO221_RS04880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO221_RS04910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO221_RS04915	COG0583	DNA-binding transcription factor activity
IXO221_RS04920	COG3634	alkyl hydroperoxide reductase activity
IXO221_RS04930	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO221_RS04970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO221_RS04970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO221_RS04985	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO221_RS05010	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO221_RS05035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO221_RS05045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO221_RS05075	COG1295	ribonuclease BN
IXO221_RS05080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO221_RS05100	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO221_RS05110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO221_RS05115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO221_RS05125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO221_RS05140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO221_RS05150	COG0193	aminoacyl-tRNA hydrolase activity
IXO221_RS05155	COG0012	GTP binding
IXO221_RS05185	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO221_RS05190	COG0250	Participates in transcription elongation, termination and antitermination
IXO221_RS05195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO221_RS05205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO221_RS05210	COG0222	ribosome binding
IXO221_RS05215	COG0085	RNA polymerase activity
IXO221_RS05220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO221_RS05225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO221_RS05230	COG0049	tRNA binding
IXO221_RS05250	COG0051	transcription antitermination factor activity, RNA binding
IXO221_RS05255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO221_RS05260	COG0088	Forms part of the polypeptide exit tunnel
IXO221_RS05265	COG0089	rRNA binding
IXO221_RS05280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO221_RS05290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO221_RS05295	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO221_RS05300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO221_RS05305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO221_RS05315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO221_RS05345	COG1841	ribosomal large subunit assembly
IXO221_RS05355	COG0201	protein transport
IXO221_RS05365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO221_RS05370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO221_RS05380	COG0203	ribosomal protein L17
IXO221_RS05440	COG3551	Protein conserved in bacteria
IXO221_RS05470	COG2194	sulfuric ester hydrolase activity
IXO221_RS05480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO221_RS05485	COG0745	RESPONSE REGULATOR receiver
IXO221_RS05490	COG0642	Histidine kinase
IXO221_RS05500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO221_RS05505	COG2894	cell division
IXO221_RS05520	COG4585	Histidine kinase
IXO221_RS05525	COG2197	response regulator
IXO221_RS05540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO221_RS05565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO221_RS05680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO221_RS05690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO221_RS05700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO221_RS05855	COG3039	Transposase
IXO221_RS05870	COG3039	Transposase
IXO221_RS05930	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO221_RS05950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO221_RS05955	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO221_RS05960	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO221_RS05975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO221_RS06050	COG0587	DNA-directed DNA polymerase activity
IXO221_RS06065	COG1297	OPT oligopeptide transporter protein
IXO221_RS06085	COG0823	Involved in the tonB-independent uptake of proteins
IXO221_RS06085	COG1506	peptidase
IXO221_RS06105	COG1917	Cupin 2, conserved barrel domain protein
IXO221_RS06105	COG2207	Transcriptional regulator
IXO221_RS06130	COG0753	catalase activity
IXO221_RS06170	COG0469	pyruvate kinase activity
IXO221_RS06175	COG3588	fructose-bisphosphate aldolase
IXO221_RS06180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO221_RS06230	COG2198	Histidine kinase
IXO221_RS06230	COG2205	protein histidine kinase activity
IXO221_RS06230	COG0784	Response regulator, receiver
IXO221_RS06250	COG0175	sulfate reduction
IXO221_RS06255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO221_RS06260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO221_RS06265	COG0175	sulfate reduction
IXO221_RS06270	COG0529	Catalyzes the synthesis of activated sulfate
IXO221_RS06270	COG2895	sulfate adenylyltransferase (ATP) activity
IXO221_RS06280	COG3039	Transposase
IXO221_RS06290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO221_RS06295	COG0308	aminopeptidase N
IXO221_RS06315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO221_RS06335	COG1970	mechanosensitive ion channel activity
IXO221_RS06365	COG3273	potassium ion transport
IXO221_RS06365	COG0471	metal ion transport
IXO221_RS06375	COG2022	thiamine diphosphate biosynthetic process
IXO221_RS06490	COG3118	belongs to the thioredoxin family
IXO221_RS06515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO221_RS06535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO221_RS06565	COG2968	Membrane
IXO221_RS06580	COG3164	Protein of unknown function
IXO221_RS06590	COG0312	modulator of DNA gyrase
IXO221_RS06595	COG3028	Belongs to the UPF0307 family
IXO221_RS06600	COG0312	modulator of DNA gyrase
IXO221_RS06625	COG0142	geranyltranstransferase activity
IXO221_RS06630	COG1722	exodeoxyribonuclease VII activity
IXO221_RS06635	COG0037	tRNA processing
IXO221_RS06640	COG1785	Belongs to the alkaline phosphatase family
IXO221_RS06660	COG0791	NLP P60 protein
IXO221_RS06665	COG0791	NLP P60 protein
IXO221_RS06670	COG1047	Peptidyl-prolyl cis-trans
IXO221_RS06675	COG2311	Membrane
IXO221_RS06680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO221_RS06720	COG0489	protein tyrosine kinase activity
IXO221_RS06725	COG0717	Belongs to the dCTP deaminase family
IXO221_RS06755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO221_RS06795	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO221_RS06800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO221_RS06805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO221_RS06810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO221_RS06830	COG0101	tRNA pseudouridine synthase activity
IXO221_RS06835	COG0135	phosphoribosylanthranilate isomerase activity
IXO221_RS06855	COG0159	tryptophan synthase activity
IXO221_RS06860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO221_RS06865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO221_RS06915	COG0149	triose-phosphate isomerase activity
IXO221_RS06930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO221_RS06940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO221_RS06945	COG0649	NAD binding
IXO221_RS06950	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO221_RS06955	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO221_RS06960	COG1034	ATP synthesis coupled electron transport
IXO221_RS06965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO221_RS06995	COG1007	ATP synthesis coupled electron transport
IXO221_RS07005	COG0779	Required for maturation of 30S ribosomal subunits
IXO221_RS07010	COG0195	Participates in both transcription termination and antitermination
IXO221_RS07015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO221_RS07030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO221_RS07035	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO221_RS07070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO221_RS07080	COG2095	MarC family integral membrane protein
IXO221_RS07095	COG1611	Belongs to the LOG family
IXO221_RS07135	COG4969	Belongs to the N-Me-Phe pilin family
IXO221_RS07140	COG0556	nucleotide-excision repair
IXO221_RS07180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO221_RS07195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO221_RS07250	COG0438	transferase activity, transferring glycosyl groups
IXO221_RS07255	COG0438	transferase activity, transferring glycosyl groups
IXO221_RS07265	COG0438	transferase activity, transferring glycosyl groups
IXO221_RS07305	COG3040	lipid binding
IXO221_RS07380	COG0784	Response regulator, receiver
IXO221_RS07380	COG4191	Histidine kinase
IXO221_RS07400	COG0552	protein localization to endoplasmic reticulum
IXO221_RS07410	COG3938	Belongs to the proline racemase family
IXO221_RS07415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO221_RS07430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO221_RS07440	COG0006	proline dipeptidase activity
IXO221_RS07455	COG0531	amino acid
IXO221_RS07485	COG4206	TonB-dependent receptor
IXO221_RS07510	COG3328	transposase activity
IXO221_RS07570	COG0746	molybdenum cofactor guanylyltransferase activity
IXO221_RS07595	COG1648	precorrin-2 dehydrogenase activity
IXO221_RS07595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO221_RS07625	COG3039	Transposase
IXO221_RS07630	COG3039	Transposase
IXO221_RS07660	COG3039	Transposase
IXO221_RS07675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO221_RS07695	COG1054	Belongs to the UPF0176 family
IXO221_RS07710	COG1530	ribonuclease E activity
IXO221_RS07720	COG3064	Membrane
IXO221_RS07735	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO221_RS07740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO221_RS07740	COG0316	Belongs to the HesB IscA family
IXO221_RS07785	COG3039	Transposase
IXO221_RS07910	COG0631	protein serine/threonine phosphatase activity
IXO221_RS07945	COG1858	cytochrome C peroxidase
IXO221_RS08005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO221_RS08030	COG2201	protein-glutamate methylesterase activity
IXO221_RS08075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO221_RS08095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO221_RS08110	COG1595	DNA-templated transcription, initiation
IXO221_RS08160	COG2244	polysaccharide biosynthetic process
IXO221_RS08190	COG2264	protein methyltransferase activity
IXO221_RS08200	COG0438	transferase activity, transferring glycosyl groups
IXO221_RS08215	COG1136	(ABC) transporter
IXO221_RS08220	COG1132	(ABC) transporter
IXO221_RS08230	COG0477	Major facilitator Superfamily
IXO221_RS08240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO221_RS08255	COG1253	flavin adenine dinucleotide binding
IXO221_RS08265	COG0306	phosphate transporter
IXO221_RS08295	COG0504	CTP synthase activity
IXO221_RS08300	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO221_RS08310	COG0148	phosphopyruvate hydratase activity
IXO221_RS08315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO221_RS08320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO221_RS08330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO221_RS08340	COG2840	Smr protein MutS2
IXO221_RS08345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO221_RS08350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO221_RS08355	COG1238	metal cluster binding
IXO221_RS08370	COG1534	Rna-binding protein
IXO221_RS08375	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO221_RS08385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO221_RS08390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO221_RS08400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO221_RS08405	COG1546	Belongs to the CinA family
IXO221_RS08420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO221_RS08425	COG2137	regulation of response to DNA damage stimulus
IXO221_RS08430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO221_RS08435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO221_RS08460	COG0305	Participates in initiation and elongation during chromosome replication
IXO221_RS08465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO221_RS08490	COG1741	Belongs to the pirin family
IXO221_RS08495	COG0583	DNA-binding transcription factor activity
IXO221_RS08520	COG0351	phosphomethylpyrimidine kinase
IXO221_RS08530	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO221_RS08535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO221_RS08555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO221_RS08565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO221_RS08570	COG3734	2-keto-3-deoxy-galactonokinase
IXO221_RS08580	COG4948	Mandelate Racemase Muconate Lactonizing
IXO221_RS08585	COG0800	Aldolase
IXO221_RS08600	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO221_RS08610	COG1070	Carbohydrate kinase
IXO221_RS08620	COG0477	Major facilitator Superfamily
IXO221_RS08640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO221_RS08685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO221_RS08690	COG2258	MOSC domain
IXO221_RS08700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO221_RS08705	COG0505	Belongs to the CarA family
IXO221_RS08715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO221_RS08720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO221_RS08730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO221_RS08790	COG2198	Histidine kinase
IXO221_RS08790	COG2205	protein histidine kinase activity
IXO221_RS08790	COG0784	Response regulator, receiver
IXO221_RS08795	COG1024	Enoyl-CoA hydratase
IXO221_RS08800	COG0318	PFAM AMP-dependent synthetase and ligase
IXO221_RS08830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO221_RS08860	COG0840	transmembrane signaling receptor activity
IXO221_RS08880	COG3039	Transposase
IXO221_RS08895	COG0835	chemotaxis
IXO221_RS08910	COG0840	transmembrane signaling receptor activity
IXO221_RS08915	COG0840	transmembrane signaling receptor activity
IXO221_RS08920	COG0840	transmembrane signaling receptor activity
IXO221_RS08925	COG0840	transmembrane signaling receptor activity
IXO221_RS08935	COG0840	transmembrane signaling receptor activity
IXO221_RS08945	COG0840	transmembrane signaling receptor activity
IXO221_RS08975	COG0745	RESPONSE REGULATOR receiver
IXO221_RS08985	COG0835	chemotaxis
IXO221_RS09000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO221_RS09020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO221_RS09030	COG4771	TonB-dependent receptor
IXO221_RS09065	COG3039	Transposase
IXO221_RS09135	COG3409	Peptidoglycan-binding domain 1 protein
IXO221_RS09135	COG3501	Rhs element vgr protein
IXO221_RS09155	COG3501	Rhs element vgr protein
IXO221_RS09155	COG3409	Peptidoglycan-binding domain 1 protein
IXO221_RS09200	COG3039	Transposase
IXO221_RS09230	COG3039	Transposase
IXO221_RS09240	COG3039	Transposase
IXO221_RS09255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO221_RS09255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO221_RS09260	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO221_RS09265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO221_RS09265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO221_RS09270	COG1609	Transcriptional regulator
IXO221_RS09295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO221_RS09300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO221_RS09310	COG2902	Dehydrogenase
IXO221_RS09315	COG3039	Transposase
IXO221_RS09325	COG0784	Response regulator, receiver
IXO221_RS09325	COG2205	protein histidine kinase activity
IXO221_RS09325	COG5002	protein histidine kinase activity
IXO221_RS09330	COG2733	membrane
IXO221_RS09345	COG1121	(ABC) transporter
IXO221_RS09350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO221_RS09355	COG2223	nitrite transmembrane transporter activity
IXO221_RS09365	COG0243	molybdopterin cofactor binding
IXO221_RS09375	COG0477	Major facilitator Superfamily
IXO221_RS09385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO221_RS09390	COG0174	glutamine synthetase
IXO221_RS09425	COG3842	ATPase activity
IXO221_RS09455	COG1012	belongs to the aldehyde dehydrogenase family
IXO221_RS09470	COG4535	Mg2 and Co2 transporter CorC
IXO221_RS09490	COG1702	phosphate starvation-inducible protein PhoH
IXO221_RS09515	COG0741	lytic transglycosylase activity
IXO221_RS09520	COG0723	plastoquinol--plastocyanin reductase activity
IXO221_RS09525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO221_RS09530	COG2857	Cytochrome c1
IXO221_RS09535	COG0625	glutathione transferase activity
IXO221_RS09540	COG2969	positive regulation of protein catabolic process
IXO221_RS09565	COG2094	Belongs to the DNA glycosylase MPG family
IXO221_RS09575	COG3328	transposase activity
IXO221_RS09640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO221_RS09660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO221_RS09665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO221_RS09665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO221_RS09670	COG0802	atpase or kinase
IXO221_RS09675	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO221_RS09680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO221_RS09700	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS09710	COG0501	Belongs to the peptidase M48B family
IXO221_RS09720	COG2081	HI0933 family
IXO221_RS09725	COG4681	YaeQ
IXO221_RS09730	COG1671	Belongs to the UPF0178 family
IXO221_RS09740	COG0625	glutathione transferase activity
IXO221_RS09750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO221_RS09755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO221_RS09760	COG0513	Belongs to the DEAD box helicase family
IXO221_RS09765	COG0488	(ABC) transporter
IXO221_RS09785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO221_RS09790	COG0483	inositol monophosphate 1-phosphatase activity
IXO221_RS09805	COG5001	Diguanylate cyclase
IXO221_RS09805	COG3300	MHYT domain
IXO221_RS09810	COG1509	lysine 2,3-aminomutase activity
IXO221_RS09825	COG0402	S-adenosylhomocysteine deaminase activity
IXO221_RS09830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO221_RS09855	COG4677	pectinesterase activity
IXO221_RS09880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO221_RS09910	COG2166	iron-sulfur cluster assembly
IXO221_RS09925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO221_RS09930	COG0137	argininosuccinate synthase activity
IXO221_RS09940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO221_RS09945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO221_RS09960	COG0165	Argininosuccinate lyase
IXO221_RS09980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO221_RS10015	COG3039	Transposase
IXO221_RS10030	COG4988	ABC transporter
IXO221_RS10035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO221_RS10045	COG3039	Transposase
IXO221_RS10130	COG3039	Transposase
IXO221_RS10165	COG3209	COG3209 Rhs family protein
IXO221_RS10175	COG3039	Transposase
IXO221_RS10210	COG2198	Histidine kinase
IXO221_RS10210	COG0784	Response regulator, receiver
IXO221_RS10210	COG0643	Histidine kinase
IXO221_RS10265	COG1684	flagellar biosynthetic protein fliR
IXO221_RS10280	COG3190	flagellar
IXO221_RS10330	COG1677	Flagellar hook-basal body complex protein FliE
IXO221_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS10370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO221_RS10390	COG2201	protein-glutamate methylesterase activity
IXO221_RS10425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO221_RS10430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO221_RS10465	COG4787	bacterial-type flagellum-dependent cell motility
IXO221_RS10475	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO221_RS10480	COG1558	bacterial-type flagellum-dependent cell motility
IXO221_RS10490	COG0784	Response regulator, receiver
IXO221_RS10490	COG0835	chemotaxis
IXO221_RS10510	COG5002	protein histidine kinase activity
IXO221_RS10520	COG4585	Histidine kinase
IXO221_RS10525	COG5001	Diguanylate cyclase
IXO221_RS10550	COG0482	sulfurtransferase activity
IXO221_RS10565	COG0542	response to heat
IXO221_RS10600	COG0492	ferredoxin-NADP+ reductase activity
IXO221_RS10605	COG1674	ftsk spoiiie
IXO221_RS10625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO221_RS10645	COG0038	chloride channel
IXO221_RS10650	COG0183	Belongs to the thiolase family
IXO221_RS10655	COG1024	Enoyl-CoA hydratase
IXO221_RS10655	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO221_RS10670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO221_RS10680	COG1426	Protein conserved in bacteria
IXO221_RS10690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO221_RS10700	COG0303	'Molybdopterin
IXO221_RS10755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO221_RS10805	COG0742	ribosomal rna small subunit methyltransferase
IXO221_RS10810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO221_RS10825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO221_RS10830	COG0405	Gamma-glutamyltransferase
IXO221_RS10855	COG3039	Transposase
IXO221_RS10930	COG0343	queuine tRNA-ribosyltransferase activity
IXO221_RS10935	COG1862	Preprotein translocase
IXO221_RS10940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO221_RS10945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO221_RS10955	COG3039	Transposase
IXO221_RS10985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO221_RS10995	COG0704	Plays a role in the regulation of phosphate uptake
IXO221_RS11010	COG0573	inorganic phosphate transmembrane transporter activity
IXO221_RS11015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO221_RS11065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO221_RS11075	COG1024	Enoyl-CoA hydratase
IXO221_RS11090	COG0494	nUDIX hydrolase
IXO221_RS11135	COG0116	Belongs to the methyltransferase superfamily
IXO221_RS11135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO221_RS11160	COG0667	Aldo Keto reductase
IXO221_RS11170	COG2925	Exonuclease
IXO221_RS11195	COG0288	reversible hydration of carbon dioxide
IXO221_RS11225	COG0316	Belongs to the HesB IscA family
IXO221_RS11230	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO221_RS11240	COG0359	binds to the 23S rRNA
IXO221_RS11250	COG3115	cell septum assembly
IXO221_RS11270	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO221_RS11290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO221_RS11315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO221_RS11325	COG2986	histidine ammonia-lyase
IXO221_RS11330	COG1228	amidohydrolase
IXO221_RS11370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO221_RS11380	COG0077	Prephenate dehydratase
IXO221_RS11380	COG1605	Chorismate mutase
IXO221_RS11385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO221_RS11415	COG4566	intracellular signal transduction
IXO221_RS11460	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO221_RS11465	COG1469	GTP cyclohydrolase I activity
IXO221_RS11475	COG0617	tRNA 3'-terminal CCA addition
IXO221_RS11485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO221_RS11490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO221_RS11520	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO221_RS11535	COG2203	Gaf domain
IXO221_RS11535	COG3706	GGDEF domain
IXO221_RS11535	COG4251	negative regulation of phosphorylation
IXO221_RS11535	COG5001	Diguanylate cyclase
IXO221_RS11595	COG1595	DNA-templated transcription, initiation
IXO221_RS11620	COG0386	Belongs to the glutathione peroxidase family
IXO221_RS11695	COG3039	Transposase
IXO221_RS11710	COG5002	protein histidine kinase activity
IXO221_RS11710	COG2205	protein histidine kinase activity
IXO221_RS11710	COG0784	Response regulator, receiver
IXO221_RS11750	COG0800	Aldolase
IXO221_RS11755	COG0129	dihydroxy-acid dehydratase activity
IXO221_RS11760	COG0363	glucosamine-6-phosphate deaminase activity
IXO221_RS11770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO221_RS11785	COG0354	folic acid binding
IXO221_RS11800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO221_RS11815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO221_RS11830	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO221_RS11855	COG0811	peptide transport
IXO221_RS11870	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO221_RS11880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO221_RS11890	COG0322	excinuclease ABC activity
IXO221_RS11925	COG3328	transposase activity
IXO221_RS11945	COG3039	Transposase
IXO221_RS11965	COG2201	protein-glutamate methylesterase activity
IXO221_RS12230	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO221_RS12230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO221_RS12240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO221_RS12250	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO221_RS12250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO221_RS12265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO221_RS12285	COG0124	histidyl-tRNA synthetase
IXO221_RS12300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO221_RS12340	COG1012	belongs to the aldehyde dehydrogenase family
IXO221_RS12360	COG0167	dihydroorotate dehydrogenase activity
IXO221_RS12365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO221_RS12370	COG0697	spore germination
IXO221_RS12395	COG0671	phosphoesterase, PA-phosphatase related
IXO221_RS12410	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO221_RS12425	COG2183	response to ionizing radiation
IXO221_RS12435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO221_RS12435	COG0723	plastoquinol--plastocyanin reductase activity
IXO221_RS12450	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO221_RS12460	COG1183	phosphatidylcholine synthase activity
IXO221_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS12490	COG0668	transmembrane transport
IXO221_RS12510	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO221_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS12560	COG0583	DNA-binding transcription factor activity
IXO221_RS12565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO221_RS12570	COG3002	Belongs to the UPF0753 family
IXO221_RS12585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO221_RS12605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO221_RS12615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO221_RS12620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO221_RS12630	COG0776	regulation of translation
IXO221_RS12635	COG0539	negative regulation of cytoplasmic translation
IXO221_RS12640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO221_RS12655	COG2957	Belongs to the agmatine deiminase family
IXO221_RS12665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO221_RS12690	COG0395	ABC-type sugar transport system, permease component
IXO221_RS12695	COG1175	transmembrane transport
IXO221_RS12725	COG2350	Protein conserved in bacteria
IXO221_RS12730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO221_RS12735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO221_RS12740	COG1187	pseudouridine synthase activity
IXO221_RS12765	COG0436	Aminotransferase
IXO221_RS12830	COG0277	FAD linked oxidase domain protein
IXO221_RS12835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO221_RS12845	COG0531	amino acid
IXO221_RS12850	COG0531	amino acid
IXO221_RS12855	COG0235	Class ii aldolase
IXO221_RS12860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO221_RS12890	COG2201	protein-glutamate methylesterase activity
IXO221_RS12940	COG0583	DNA-binding transcription factor activity
IXO221_RS12950	COG3039	Transposase
IXO221_RS13050	COG3039	Transposase
IXO221_RS13060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO221_RS13080	COG0557	exoribonuclease II activity
IXO221_RS13105	COG1960	acyl-CoA dehydrogenase activity
IXO221_RS13110	COG2226	methyltransferase
IXO221_RS13115	COG0646	methionine synthase
IXO221_RS13115	COG1410	methionine synthase
IXO221_RS13120	COG0646	methionine synthase
IXO221_RS13120	COG1410	methionine synthase
IXO221_RS13130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO221_RS13140	COG1609	Transcriptional regulator
IXO221_RS13155	COG2900	Belongs to the SlyX family
IXO221_RS13170	COG0386	Belongs to the glutathione peroxidase family
IXO221_RS13180	COG1725	Transcriptional regulator
IXO221_RS13185	COG1131	(ABC) transporter
IXO221_RS13245	COG2850	peptidyl-arginine hydroxylation
IXO221_RS13280	COG1132	(ABC) transporter
IXO221_RS13305	COG0287	Prephenate dehydrogenase
IXO221_RS13305	COG1605	Chorismate mutase
IXO221_RS13310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO221_RS13315	COG0484	heat shock protein binding
IXO221_RS13320	COG0443	Heat shock 70 kDa protein
IXO221_RS13325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO221_RS13335	COG0497	DNA recombination
IXO221_RS13345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO221_RS13350	COG2914	Belongs to the UPF0125 (RnfH) family
IXO221_RS13360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO221_RS13375	COG1960	acyl-CoA dehydrogenase activity
IXO221_RS13385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO221_RS13440	COG2814	Major facilitator Superfamily
IXO221_RS13445	COG1566	PFAM secretion protein HlyD family protein
IXO221_RS13460	COG2207	Transcriptional regulator
IXO221_RS13485	COG4774	siderophore transport
IXO221_RS13495	COG0367	asparagine synthase
IXO221_RS13510	COG1393	Belongs to the ArsC family
IXO221_RS13525	COG3039	Transposase
IXO221_RS13575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO221_RS13590	COG0233	cytoplasmic translational termination
IXO221_RS13600	COG0575	Belongs to the CDS family
IXO221_RS13610	COG0750	zinc metalloprotease
IXO221_RS13630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO221_RS13635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO221_RS13655	COG0825	malonyl-CoA metabolic process
IXO221_RS13665	COG4771	TonB-dependent receptor
IXO221_RS13670	COG1131	(ABC) transporter
IXO221_RS13695	COG1981	membrane
IXO221_RS13740	COG2895	sulfate adenylyltransferase (ATP) activity
IXO221_RS13740	COG0529	Catalyzes the synthesis of activated sulfate
IXO221_RS13775	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO221_RS13790	COG2040	homocysteine
IXO221_RS13795	COG0833	amino acid
IXO221_RS13815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO221_RS13815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO221_RS13825	COG2878	Part of a membrane complex involved in electron transport
IXO221_RS13840	COG1595	DNA-templated transcription, initiation
IXO221_RS13865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO221_RS13880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO221_RS13885	COG0251	oxidation-reduction process
IXO221_RS13895	COG0392	lysyltransferase activity
IXO221_RS13895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO221_RS13925	COG3039	Transposase
IXO221_RS13935	COG2814	Major facilitator Superfamily
IXO221_RS13940	COG1902	pentaerythritol trinitrate reductase activity
IXO221_RS13950	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO221_RS13965	COG1047	Peptidyl-prolyl cis-trans
IXO221_RS14005	COG3039	Transposase
IXO221_RS14010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO221_RS14025	COG1451	nucleotide metabolic process
IXO221_RS14045	COG0183	Belongs to the thiolase family
IXO221_RS14075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO221_RS14075	COG1793	dna ligase
IXO221_RS14085	COG1793	dna ligase
IXO221_RS14090	COG1201	RNA secondary structure unwinding
IXO221_RS14110	COG1278	Cold shock
IXO221_RS14115	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO221_RS14120	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO221_RS14130	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO221_RS14140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO221_RS14165	COG3039	Transposase
IXO221_RS14175	COG2954	triphosphatase activity
IXO221_RS14190	COG1381	Involved in DNA repair and RecF pathway recombination
IXO221_RS14220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO221_RS14235	COG1024	Enoyl-CoA hydratase
IXO221_RS14235	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO221_RS14255	COG1024	Enoyl-CoA hydratase
IXO221_RS14260	COG1960	acyl-CoA dehydrogenase activity
IXO221_RS14330	COG2353	YceI-like domain
IXO221_RS14340	COG2353	YceI-like domain
IXO221_RS14355	COG1760	l-serine dehydratase
IXO221_RS14365	COG0626	cystathionine gamma-synthase activity
IXO221_RS14370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO221_RS14375	COG0739	heme binding
IXO221_RS14385	COG1272	protein, Hemolysin III
IXO221_RS14410	COG0463	Glycosyl transferase, family 2
IXO221_RS14420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO221_RS14430	COG4771	TonB-dependent receptor
IXO221_RS14435	COG1309	transcriptional regulator
IXO221_RS14445	COG1960	acyl-CoA dehydrogenase activity
IXO221_RS14475	COG0509	glycine decarboxylation via glycine cleavage system
IXO221_RS14490	COG0330	HflC and HflK could
IXO221_RS14505	COG3956	TIGRFAM MazG family protein
IXO221_RS14515	COG0494	nUDIX hydrolase
IXO221_RS14525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO221_RS14530	COG0837	glucose binding
IXO221_RS14545	COG1388	LysM domain
IXO221_RS14545	COG3858	chitin binding
IXO221_RS14555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO221_RS14565	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO221_RS14605	COG3537	Alpha-1,2-mannosidase
IXO221_RS14645	COG3142	Participates in the control of copper homeostasis
IXO221_RS14650	COG1446	asparaginase
IXO221_RS14660	COG2304	oxidoreductase activity
IXO221_RS14665	COG2304	oxidoreductase activity
IXO221_RS14705	COG2198	Histidine kinase
IXO221_RS14705	COG0784	Response regulator, receiver
IXO221_RS14705	COG0643	Histidine kinase
IXO221_RS14710	COG0840	transmembrane signaling receptor activity
IXO221_RS14715	COG0835	chemotaxis
IXO221_RS14730	COG0189	ligase activity
IXO221_RS14740	COG1397	ADP-ribosylglycohydrolase
IXO221_RS14750	COG1199	ATP-dependent helicase activity
IXO221_RS14760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO221_RS14765	COG1215	transferase activity, transferring glycosyl groups
IXO221_RS14775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO221_RS14795	COG0535	radical SAM domain protein
IXO221_RS14800	COG0535	radical SAM domain protein
IXO221_RS14835	COG1643	Atp-dependent helicase
IXO221_RS14840	COG0783	Belongs to the Dps family
IXO221_RS14845	COG0514	ATP-dependent DNA helicase (RecQ)
IXO221_RS14870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO221_RS14925	COG1187	pseudouridine synthase activity
IXO221_RS14930	COG0602	queuosine metabolic process
IXO221_RS14940	COG2885	chlorophyll binding
IXO221_RS14955	COG0848	biopolymer transport protein
IXO221_RS14965	COG0824	Thioesterase
IXO221_RS14970	COG2255	four-way junction helicase activity
IXO221_RS14980	COG0632	four-way junction helicase activity
IXO221_RS15115	COG3209	COG3209 Rhs family protein
IXO221_RS15135	COG3209	COG3209 Rhs family protein
IXO221_RS15135	COG3209	COG3209 Rhs family protein
IXO221_RS15160	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO221_RS15165	COG1845	cytochrome c oxidase, subunit III
IXO221_RS15170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO221_RS15185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO221_RS15190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO221_RS15200	COG0196	riboflavin kinase activity
IXO221_RS15205	COG0728	peptidoglycan biosynthetic process
IXO221_RS15210	COG0268	Binds directly to 16S ribosomal RNA
IXO221_RS15215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO221_RS15220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO221_RS15230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO221_RS15235	COG0824	Thioesterase
IXO221_RS15250	COG1946	Acyl-CoA thioesterase
IXO221_RS15275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO221_RS15315	COG1877	trehalose-phosphatase activity
IXO221_RS15320	COG3387	PFAM Glycoside hydrolase 15-related
IXO221_RS15345	COG0564	pseudouridine synthase activity
IXO221_RS15350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO221_RS15355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO221_RS15355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO221_RS15365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO221_RS15370	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO221_RS15395	COG2184	nucleotidyltransferase activity
IXO221_RS15415	COG2194	sulfuric ester hydrolase activity
IXO221_RS15420	COG4969	Belongs to the N-Me-Phe pilin family
IXO221_RS15430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO221_RS15450	COG3039	Transposase
IXO221_RS15500	COG1132	(ABC) transporter
IXO221_RS15530	COG0745	RESPONSE REGULATOR receiver
IXO221_RS15535	COG5000	phosphorelay sensor kinase activity
IXO221_RS15535	COG5002	protein histidine kinase activity
IXO221_RS15540	COG0475	glutathione-regulated potassium exporter activity
IXO221_RS15550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO221_RS15570	COG1187	pseudouridine synthase activity
IXO221_RS15575	COG5002	protein histidine kinase activity
IXO221_RS15575	COG5001	Diguanylate cyclase
IXO221_RS15690	COG0415	Belongs to the DNA photolyase family
IXO221_RS15695	COG0305	Participates in initiation and elongation during chromosome replication
IXO221_RS15705	COG0367	asparagine synthase
IXO221_RS15720	COG1960	acyl-CoA dehydrogenase activity
IXO221_RS15735	COG0084	hydrolase, TatD family'
IXO221_RS15740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO221_RS15800	COG0735	belongs to the Fur family
IXO221_RS15805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO221_RS15830	COG3039	Transposase
IXO221_RS15840	COG3039	Transposase
IXO221_RS15910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO221_RS15920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO221_RS15935	COG2198	Histidine kinase
IXO221_RS15935	COG0643	Histidine kinase
IXO221_RS15940	COG0840	transmembrane signaling receptor activity
IXO221_RS15945	COG0835	chemotaxis
IXO221_RS15950	COG2199	diguanylate cyclase activity
IXO221_RS15950	COG2200	EAL domain
IXO221_RS15950	COG2202	Pas domain
IXO221_RS15955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO221_RS15970	COG3590	peptidase
IXO221_RS15985	COG0588	phosphoglycerate mutase activity
IXO221_RS15990	COG1515	deoxyribonuclease V activity
IXO221_RS16000	COG1741	Belongs to the pirin family
IXO221_RS16065	COG1741	Belongs to the pirin family
IXO221_RS16070	COG1966	Carbon starvation protein
IXO221_RS16075	COG2879	small protein
IXO221_RS16115	COG4251	negative regulation of phosphorylation
IXO221_RS16115	COG5001	Diguanylate cyclase
IXO221_RS16115	COG3706	GGDEF domain
IXO221_RS16115	COG2203	Gaf domain
IXO221_RS16120	COG0629	single-stranded DNA binding
IXO221_RS16125	COG0142	geranyltranstransferase activity
IXO221_RS16150	COG0527	aspartate kinase activity
IXO221_RS16160	COG0384	phenazine biosynthesis protein PhzF
IXO221_RS16170	COG1764	response to oxidative stress
IXO221_RS16185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO221_RS16190	COG1678	Uncharacterized ACR, COG1678
IXO221_RS16205	COG0519	Catalyzes the synthesis of GMP from XMP
IXO221_RS16235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO221_RS16295	COG1959	2 iron, 2 sulfur cluster binding
IXO221_RS16300	COG0719	Fe-S assembly protein
IXO221_RS16305	COG0396	ATPase activity
IXO221_RS16310	COG0719	Fe-S assembly protein
IXO221_RS16315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO221_RS16325	COG2146	nitrite reductase [NAD(P)H] activity
IXO221_RS16350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO221_RS16365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO221_RS16375	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO221_RS16380	COG0174	glutamine synthetase
IXO221_RS16385	COG3328	transposase activity
IXO221_RS16410	COG0326	Molecular chaperone. Has ATPase activity
IXO221_RS16415	COG2207	Transcriptional regulator
IXO221_RS16445	COG0657	acetylesterase activity
IXO221_RS16445	COG2755	lipolytic protein G-D-S-L family
IXO221_RS16470	COG0488	(ABC) transporter
IXO221_RS16505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO221_RS16505	COG4651	solute:proton antiporter activity
IXO221_RS16520	COG4772	TonB-dependent receptor
IXO221_RS16530	COG4264	IucA IucC family
IXO221_RS16535	COG2814	Major facilitator Superfamily
IXO221_RS16545	COG0019	diaminopimelate decarboxylase activity
IXO221_RS16610	COG4206	TonB-dependent receptor
IXO221_RS16645	COG0542	response to heat
IXO221_RS16685	COG0534	Mate efflux family protein
IXO221_RS16700	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO221_RS16705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO221_RS16710	COG0228	four-way junction DNA binding
IXO221_RS16730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO221_RS16740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO221_RS16785	COG1555	photosystem II stabilization
IXO221_RS16790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO221_RS16805	COG3178	'Phosphotransferase
IXO221_RS16810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO221_RS16820	COG0628	permease
IXO221_RS16830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO221_RS16845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO221_RS16870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO221_RS16875	COG0271	Belongs to the BolA IbaG family
IXO221_RS16885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO221_RS16895	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO221_RS16900	COG1137	ATPase activity
IXO221_RS16915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO221_RS16920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO221_RS16925	COG1660	Displays ATPase and GTPase activities
IXO221_RS16940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO221_RS16945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO221_RS16950	COG2239	Acts as a magnesium transporter
IXO221_RS16960	COG1294	oxidase, subunit
IXO221_RS16965	COG1271	oxidase subunit
IXO221_RS16980	COG1113	amino acid transport
IXO221_RS16995	COG2197	response regulator
IXO221_RS17000	COG0531	amino acid
IXO221_RS17060	COG0754	glutathionylspermidine amidase activity
IXO221_RS17085	COG1842	Phage shock protein A
IXO221_RS17100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO221_RS17105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO221_RS17115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO221_RS17145	COG2201	protein-glutamate methylesterase activity
IXO221_RS17195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO221_RS17245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO221_RS17250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO221_RS17280	COG3039	Transposase
IXO221_RS17295	COG0745	RESPONSE REGULATOR receiver
IXO221_RS17300	COG2205	protein histidine kinase activity
IXO221_RS17320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO221_RS17350	COG3453	Protein conserved in bacteria
IXO221_RS17350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO221_RS17355	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO221_RS17360	COG4149	molybdate abc transporter
IXO221_RS17365	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO221_RS17385	COG0642	Histidine kinase
IXO221_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS17410	COG1022	Amp-dependent synthetase and ligase
IXO221_RS17435	COG1376	ErfK ybiS ycfS ynhG family protein
IXO221_RS17440	COG0739	heme binding
IXO221_RS17450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO221_RS17455	COG1301	dicarboxylic acid transport
IXO221_RS17475	COG2304	oxidoreductase activity
IXO221_RS17495	COG0714	Associated with various cellular activities
IXO221_RS17550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO221_RS17575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO221_RS17585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO221_RS17610	COG1561	YicC-like family, N-terminal region
IXO221_RS17615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO221_RS17630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO221_RS17665	COG0006	proline dipeptidase activity
IXO221_RS17690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO221_RS17700	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO221_RS17710	COG2912	Transglutaminase-like superfamily
IXO221_RS17715	COG1773	rubredoxin
IXO221_RS17720	COG0352	thiamine-phosphate diphosphorylase activity
IXO221_RS17790	COG0280	phosphate acetyltransferase
IXO221_RS17790	COG0281	malic enzyme
IXO221_RS17810	COG4191	Histidine kinase
IXO221_RS17825	COG0583	DNA-binding transcription factor activity
IXO221_RS17845	COG2197	response regulator
IXO221_RS17855	COG0642	Histidine kinase
IXO221_RS17870	COG2851	Citrate transporter
IXO221_RS17875	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS17880	COG1609	Transcriptional regulator
IXO221_RS17890	COG2211	Major facilitator Superfamily
IXO221_RS17915	COG1162	GTPase activity
IXO221_RS17940	COG0726	polysaccharide deacetylase
IXO221_RS17945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO221_RS17970	COG3039	Transposase
IXO221_RS17975	COG3039	Transposase
IXO221_RS18020	COG0242	peptide deformylase activity
IXO221_RS18040	COG0714	Associated with various cellular activities
IXO221_RS18060	COG0537	adenosine 5'-monophosphoramidase activity
IXO221_RS18090	COG0314	molybdopterin synthase activity
IXO221_RS18095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO221_RS18100	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO221_RS18110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO221_RS18115	COG1234	tRNA 3'-trailer cleavage
IXO221_RS18120	COG3642	lipopolysaccharide core region biosynthetic process
IXO221_RS18125	COG0859	PFAM glycosyl transferase family 9
IXO221_RS18135	COG0582	viral genome integration into host DNA
IXO221_RS18195	COG0631	protein serine/threonine phosphatase activity
IXO221_RS18205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO221_RS18230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO221_RS18270	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO221_RS18320	COG0473	3-isopropylmalate dehydrogenase activity
IXO221_RS18345	COG4783	chaperone-mediated protein folding
IXO221_RS18360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO221_RS18370	COG0438	transferase activity, transferring glycosyl groups
IXO221_RS18375	COG0671	phosphoesterase, PA-phosphatase related
IXO221_RS18380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO221_RS18400	COG2833	Protein of unknown function (DUF455)
IXO221_RS18420	COG0285	dihydrofolate synthase activity
IXO221_RS18430	COG0588	phosphoglycerate mutase activity
IXO221_RS18460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO221_RS18465	COG4208	sulfate ABC transporter
IXO221_RS18470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO221_RS18475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO221_RS18480	COG0156	8-amino-7-oxononanoate synthase activity
IXO221_RS18505	COG0604	alcohol dehydrogenase
IXO221_RS18510	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO221_RS18510	COG1902	pentaerythritol trinitrate reductase activity
IXO221_RS18635	COG3386	PFAM SMP-30 Gluconolaconase
IXO221_RS18655	COG1024	Enoyl-CoA hydratase
IXO221_RS18665	COG0318	PFAM AMP-dependent synthetase and ligase
IXO221_RS18670	COG0583	DNA-binding transcription factor activity
IXO221_RS18710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO221_RS18715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO221_RS18725	COG2096	Adenosyltransferase
IXO221_RS18730	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO221_RS18745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO221_RS18755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO221_RS18760	COG2967	ApaG domain
IXO221_RS18785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO221_RS18805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO221_RS18825	COG0642	Histidine kinase
IXO221_RS18840	COG4181	ATPase activity
IXO221_RS18850	COG2175	clavaminate synthase activity
IXO221_RS18905	COG0667	Aldo Keto reductase
IXO221_RS18915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO221_RS18920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO221_RS18930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO221_RS18945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO221_RS18990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO221_RS18995	COG2226	methyltransferase
IXO221_RS19040	COG3321	synthase
IXO221_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS19040	COG0604	alcohol dehydrogenase
IXO221_RS19050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO221_RS19065	COG0494	nUDIX hydrolase
IXO221_RS19080	COG1388	LysM domain
IXO221_RS19080	COG4942	peptidase
IXO221_RS19090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO221_RS19105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO221_RS19110	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO221_RS19115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO221_RS19130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO221_RS19135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO221_RS19150	COG3116	cell division
IXO221_RS19155	COG0275	rRNA processing
IXO221_RS19190	COG0792	nuclease activity
IXO221_RS19195	COG1988	membrane-bound metal-dependent
IXO221_RS19200	COG0277	FAD linked oxidase domain protein
IXO221_RS19205	COG0745	RESPONSE REGULATOR receiver
IXO221_RS19210	COG2205	protein histidine kinase activity
IXO221_RS19220	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO221_RS19225	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO221_RS19245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO221_RS19250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO221_RS19255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO221_RS19275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO221_RS19275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO221_RS19295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO221_RS19315	COG0488	(ABC) transporter
IXO221_RS19340	COG3791	Glutathione-dependent formaldehyde-activating
IXO221_RS19370	COG2205	protein histidine kinase activity
IXO221_RS19430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO221_RS19465	COG3039	Transposase
IXO221_RS19475	COG3039	Transposase
IXO221_RS19480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO221_RS19490	COG3039	Transposase
IXO221_RS19575	COG1649	PFAM Uncharacterised BCR, COG1649
IXO221_RS19575	COG0726	polysaccharide deacetylase
IXO221_RS19580	COG1215	transferase activity, transferring glycosyl groups
IXO221_RS19590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO221_RS19595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO221_RS19600	COG1609	Transcriptional regulator
IXO221_RS19610	COG2188	Transcriptional regulator
IXO221_RS19625	COG3250	beta-galactosidase activity
IXO221_RS19675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO221_RS19680	COG4191	Histidine kinase
IXO221_RS19685	COG0784	Response regulator, receiver
IXO221_RS19690	COG4251	negative regulation of phosphorylation
IXO221_RS19695	COG2823	Periplasmic or secreted lipoprotein
IXO221_RS19700	COG0673	inositol 2-dehydrogenase activity
IXO221_RS19705	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO221_RS19740	COG1056	cytidyltransferase-related domain
IXO221_RS19740	COG1051	belongs to the nudix hydrolase family
IXO221_RS19765	COG2921	Belongs to the UPF0250 family
IXO221_RS19780	COG1686	Belongs to the peptidase S11 family
IXO221_RS19785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO221_RS19790	COG2951	lytic endotransglycosylase activity
IXO221_RS19860	COG0772	Belongs to the SEDS family
IXO221_RS19875	COG1792	Involved in formation and maintenance of cell shape
IXO221_RS19880	COG1077	Cell shape determining protein MreB Mrl
IXO221_RS19885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO221_RS19935	COG2199	diguanylate cyclase activity
IXO221_RS19940	COG0308	aminopeptidase N
IXO221_RS19970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO221_RS20000	COG0436	Aminotransferase
IXO221_RS20005	COG3039	Transposase
IXO221_RS20025	COG1505	serine-type exopeptidase activity
IXO221_RS20050	COG0181	hydroxymethylbilane synthase activity
IXO221_RS20060	COG3275	phosphorelay sensor kinase activity
IXO221_RS20095	COG0659	secondary active sulfate transmembrane transporter activity
IXO221_RS20100	COG5297	Belongs to the glycosyl hydrolase family 6
IXO221_RS20100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO221_RS20170	COG0598	Magnesium transport protein CorA
IXO221_RS20180	COG1113	amino acid transport
IXO221_RS20190	COG5297	Belongs to the glycosyl hydrolase family 6
IXO221_RS20195	COG4305	rare lipoprotein A
IXO221_RS20200	COG0697	spore germination
IXO221_RS20260	COG4221	oxidoreductase activity
IXO221_RS20290	COG0456	acetyltransferase
IXO221_RS20300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO221_RS20340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO221_RS20340	COG2111	Na H antiporter
IXO221_RS20345	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO221_RS20350	COG0651	ATP synthesis coupled electron transport
IXO221_RS20360	COG2212	antiporter activity
IXO221_RS20365	COG1320	monovalent cation:proton antiporter activity
IXO221_RS20375	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO221_RS20395	COG3104	oligopeptide transport
IXO221_RS20400	COG3483	tryptophan 2,3-dioxygenase activity
IXO221_RS20450	COG0183	Belongs to the thiolase family
IXO221_RS20520	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO221_RS20525	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO221_RS20535	COG4948	Mandelate Racemase Muconate Lactonizing
IXO221_RS20560	COG0531	amino acid
IXO221_RS20585	COG4682	membrane
IXO221_RS20590	COG2133	pyrroloquinoline quinone binding
IXO221_RS20630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO221_RS20635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO221_RS20645	COG1610	YqeY-like protein
IXO221_RS20655	COG1295	ribonuclease BN
IXO221_RS20660	COG0358	DNA primase activity
IXO221_RS20725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO221_RS20740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO221_RS20790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO221_RS20795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO221_RS20800	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO221_RS20810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO221_RS20825	COG0134	indole-3-glycerol-phosphate synthase activity
IXO221_RS20830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO221_RS20895	COG3039	Transposase
IXO221_RS20910	COG3039	Transposase
IXO221_RS20930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO221_RS20930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO221_RS20940	COG1473	amidohydrolase
IXO221_RS20945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO221_RS20950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO221_RS20960	COG5383	Protein conserved in bacteria
IXO221_RS20995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO221_RS21000	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO221_RS21015	COG0028	Belongs to the TPP enzyme family
IXO221_RS21025	COG4191	Histidine kinase
IXO221_RS21050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO221_RS21065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO221_RS21070	COG3177	Filamentation induced by cAMP protein fic
IXO221_RS21085	COG0596	Alpha beta hydrolase
IXO221_RS21090	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO221_RS21095	COG0318	PFAM AMP-dependent synthetase and ligase
IXO221_RS21100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO221_RS21150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO221_RS21160	COG0129	dihydroxy-acid dehydratase activity
IXO221_RS21180	COG3039	Transposase
IXO221_RS21190	COG0408	coproporphyrinogen oxidase activity
IXO221_RS21230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO221_RS21295	COG2353	YceI-like domain
IXO221_RS21325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO221_RS21340	COG3386	PFAM SMP-30 Gluconolaconase
IXO221_RS21370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO221_RS21390	COG0459	protein refolding
IXO221_RS21415	COG1252	NADH dehydrogenase
IXO221_RS21425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO221_RS21430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO221_RS21435	COG2201	protein-glutamate methylesterase activity
IXO221_RS21440	COG2177	Part of the ABC transporter FtsEX involved in
IXO221_RS21445	COG2884	Cell division ATP-binding protein ftsE
IXO221_RS21455	COG3118	belongs to the thioredoxin family
IXO221_RS21460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO221_RS21475	COG0729	surface antigen
IXO221_RS21480	COG2911	Protein conserved in bacteria
IXO221_RS21530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO221_RS21580	COG1733	regulation of RNA biosynthetic process
IXO221_RS21585	COG0702	epimerase
IXO221_RS21615	COG0583	DNA-binding transcription factor activity
IXO221_RS21620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO221_RS21640	COG0745	RESPONSE REGULATOR receiver
IXO221_RS21670	COG1902	pentaerythritol trinitrate reductase activity
IXO221_RS21675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO221_RS21685	COG2814	Major facilitator Superfamily
IXO221_RS21690	COG0583	DNA-binding transcription factor activity
IXO221_RS21705	COG0084	hydrolase, TatD family'
IXO221_RS21750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO221_RS21775	COG2351	hydroxyisourate hydrolase activity
IXO221_RS21835	COG4770	biotin carboxylase activity
IXO221_RS21840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO221_RS21845	COG1960	acyl-CoA dehydrogenase activity
IXO221_RS21895	COG0523	cobalamin synthesis protein
IXO221_RS21915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO221_RS21935	COG4771	TonB-dependent receptor
IXO221_RS21940	COG0457	Tetratricopeptide repeat
IXO221_RS21950	COG0752	glycyl-tRNA synthetase alpha subunit
IXO221_RS21955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO221_RS21970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO221_RS21970	COG0519	Catalyzes the synthesis of GMP from XMP
IXO221_RS21980	COG0805	protein transport
IXO221_RS21990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO221_RS22000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO221_RS22025	COG2974	May be involved in recombination
IXO221_RS22030	COG0037	tRNA processing
IXO221_RS22050	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO221_RS22060	COG4948	Mandelate Racemase Muconate Lactonizing
IXO221_RS22070	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO221_RS22075	COG0246	Mannitol dehydrogenase
IXO221_RS22100	COG3693	PFAM glycoside hydrolase, family 10
IXO221_RS22125	COG2211	Major facilitator Superfamily
IXO221_RS22210	COG1846	Transcriptional regulator
IXO221_RS22215	COG1764	response to oxidative stress
IXO221_RS22300	COG3549	Plasmid maintenance system killer
IXO221_RS22310	COG1074	ATP-dependent DNA helicase activity
IXO221_RS22315	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO221_RS22330	COG1196	nuclear chromosome segregation
IXO221_RS22365	COG2032	superoxide dismutase activity
IXO221_RS22370	COG2032	superoxide dismutase activity
IXO221_RS22375	COG2204	response regulator
IXO221_RS22380	COG3852	Histidine kinase
IXO221_RS22385	COG0004	ammonium transporteR
IXO221_RS22390	COG0347	Belongs to the P(II) protein family
IXO221_RS22395	COG0174	glutamine synthetase
IXO221_RS22400	COG1968	undecaprenyl-diphosphatase activity
IXO221_RS22440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO221_RS22450	COG2062	phosphohistidine phosphatase, SixA
IXO221_RS22455	COG0489	protein tyrosine kinase activity
IXO221_RS22475	COG1396	sequence-specific DNA binding
IXO221_RS22480	COG3550	peptidyl-serine autophosphorylation
IXO221_RS22485	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO221_RS22490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO221_RS22505	COG0517	IMP dehydrogenase activity
IXO221_RS22505	COG1125	glycine betaine transport
IXO221_RS22520	COG1119	ATPase activity
IXO221_RS22530	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO221_RS22545	COG3039	Transposase
IXO221_RS22570	COG0656	L-ascorbic acid biosynthetic process
IXO221_RS22575	COG2130	NADP-dependent
IXO221_RS22580	COG0667	Aldo Keto reductase
IXO221_RS22590	COG1187	pseudouridine synthase activity
IXO221_RS22600	COG1643	Atp-dependent helicase
IXO221_RS22605	COG4807	Protein conserved in bacteria
IXO221_RS22610	COG4948	Mandelate Racemase Muconate Lactonizing
IXO221_RS22615	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO221_RS22620	COG1028	Short-chain dehydrogenase reductase Sdr
IXO221_RS22680	COG3162	membrane
IXO221_RS22685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO221_RS22700	COG0708	Exodeoxyribonuclease III
IXO221_RS22715	COG2091	lysine biosynthetic process via aminoadipic acid
IXO221_RS22725	COG3540	Alkaline phosphatase
IXO221_RS22730	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO221_RS22760	COG2159	amidohydrolase
IXO221_RS22770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO221_RS22775	COG0583	DNA-binding transcription factor activity
IXO221_RS22780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO221_RS22795	COG0210	DNA helicase
IXO221_RS22815	COG0531	amino acid
IXO221_RS22825	COG1322	Protein conserved in bacteria
IXO221_RS22835	COG0386	Belongs to the glutathione peroxidase family
IXO221_RS22890	COG0793	Belongs to the peptidase S41A family
IXO221_RS22895	COG4942	peptidase
IXO221_RS22905	COG2234	aminopeptidase activity
IXO221_RS22950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO221_RS22955	COG0302	gtp cyclohydrolase
IXO221_RS22980	COG0477	Major facilitator Superfamily
IXO221_RS23045	COG1929	Belongs to the glycerate kinase type-1 family
IXO221_RS23050	COG2271	Major facilitator Superfamily
IXO221_RS23065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO221_RS23070	COG0861	Integral membrane protein TerC family
IXO221_RS23085	COG0584	glycerophosphoryl diester phosphodiesterase
IXO221_RS23095	COG0671	phosphoesterase, PA-phosphatase related
IXO221_RS23100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO221_RS23105	COG0726	polysaccharide deacetylase