locus-tag	class	description
IXO608_RS00050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO608_RS00070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO608_RS00085	COG1595	DNA-templated transcription, initiation
IXO608_RS00135	COG2244	polysaccharide biosynthetic process
IXO608_RS00165	COG2264	protein methyltransferase activity
IXO608_RS00175	COG0438	transferase activity, transferring glycosyl groups
IXO608_RS00195	COG1136	(ABC) transporter
IXO608_RS00200	COG1132	(ABC) transporter
IXO608_RS00210	COG0477	Major facilitator Superfamily
IXO608_RS00220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO608_RS00235	COG1253	flavin adenine dinucleotide binding
IXO608_RS00245	COG0306	phosphate transporter
IXO608_RS00250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IXO608_RS00275	COG0504	CTP synthase activity
IXO608_RS00280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO608_RS00290	COG0148	phosphopyruvate hydratase activity
IXO608_RS00295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO608_RS00310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO608_RS00320	COG2840	Smr protein MutS2
IXO608_RS00325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO608_RS00330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO608_RS00335	COG1238	metal cluster binding
IXO608_RS00350	COG1534	Rna-binding protein
IXO608_RS00355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO608_RS00365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO608_RS00380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO608_RS00385	COG1546	Belongs to the CinA family
IXO608_RS00400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO608_RS00405	COG2137	regulation of response to DNA damage stimulus
IXO608_RS00410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO608_RS00415	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO608_RS00435	COG0305	Participates in initiation and elongation during chromosome replication
IXO608_RS00440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO608_RS00455	COG1741	Belongs to the pirin family
IXO608_RS00460	COG0583	DNA-binding transcription factor activity
IXO608_RS00485	COG0351	phosphomethylpyrimidine kinase
IXO608_RS00495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO608_RS00500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO608_RS00515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO608_RS00525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO608_RS00530	COG3734	2-keto-3-deoxy-galactonokinase
IXO608_RS00540	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_RS00545	COG0800	Aldolase
IXO608_RS00560	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO608_RS00570	COG1070	Carbohydrate kinase
IXO608_RS00580	COG0477	Major facilitator Superfamily
IXO608_RS00600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO608_RS00645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO608_RS00650	COG2258	MOSC domain
IXO608_RS00660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO608_RS00665	COG0505	Belongs to the CarA family
IXO608_RS00675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO608_RS00680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO608_RS00690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO608_RS00760	COG0784	Response regulator, receiver
IXO608_RS00760	COG2198	Histidine kinase
IXO608_RS00760	COG2205	protein histidine kinase activity
IXO608_RS00765	COG1024	Enoyl-CoA hydratase
IXO608_RS00770	COG0318	PFAM AMP-dependent synthetase and ligase
IXO608_RS00800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO608_RS00830	COG0840	transmembrane signaling receptor activity
IXO608_RS00850	COG0835	chemotaxis
IXO608_RS00870	COG0840	transmembrane signaling receptor activity
IXO608_RS00875	COG0840	transmembrane signaling receptor activity
IXO608_RS00880	COG0840	transmembrane signaling receptor activity
IXO608_RS00885	COG0840	transmembrane signaling receptor activity
IXO608_RS00895	COG0840	transmembrane signaling receptor activity
IXO608_RS00905	COG0840	transmembrane signaling receptor activity
IXO608_RS00935	COG0745	RESPONSE REGULATOR receiver
IXO608_RS00945	COG0835	chemotaxis
IXO608_RS00955	COG1360	Flagellar Motor Protein
IXO608_RS00960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO608_RS00980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO608_RS00990	COG4771	TonB-dependent receptor
IXO608_RS01015	COG3039	Transposase
IXO608_RS01060	COG3409	Peptidoglycan-binding domain 1 protein
IXO608_RS01060	COG3501	Rhs element vgr protein
IXO608_RS01080	COG3409	Peptidoglycan-binding domain 1 protein
IXO608_RS01080	COG3501	Rhs element vgr protein
IXO608_RS01155	COG3039	Transposase
IXO608_RS01170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO608_RS01170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO608_RS01175	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO608_RS01180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO608_RS01180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO608_RS01185	COG1609	Transcriptional regulator
IXO608_RS01205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO608_RS01210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO608_RS01220	COG2902	Dehydrogenase
IXO608_RS01225	COG3039	Transposase
IXO608_RS01235	COG5002	protein histidine kinase activity
IXO608_RS01235	COG2205	protein histidine kinase activity
IXO608_RS01235	COG0784	Response regulator, receiver
IXO608_RS01240	COG2733	membrane
IXO608_RS01250	COG1121	(ABC) transporter
IXO608_RS01255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO608_RS01265	COG2223	nitrite transmembrane transporter activity
IXO608_RS01275	COG0243	molybdopterin cofactor binding
IXO608_RS01285	COG0477	Major facilitator Superfamily
IXO608_RS01295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_RS01300	COG0174	glutamine synthetase
IXO608_RS01335	COG3842	ATPase activity
IXO608_RS01355	COG1012	belongs to the aldehyde dehydrogenase family
IXO608_RS01370	COG4535	Mg2 and Co2 transporter CorC
IXO608_RS01390	COG1702	phosphate starvation-inducible protein PhoH
IXO608_RS01420	COG0741	lytic transglycosylase activity
IXO608_RS01425	COG0723	plastoquinol--plastocyanin reductase activity
IXO608_RS01430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO608_RS01435	COG2857	Cytochrome c1
IXO608_RS01440	COG0625	glutathione transferase activity
IXO608_RS01445	COG2969	positive regulation of protein catabolic process
IXO608_RS01470	COG2094	Belongs to the DNA glycosylase MPG family
IXO608_RS01480	COG3328	transposase activity
IXO608_RS01550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO608_RS01570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO608_RS01575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO608_RS01575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO608_RS01580	COG0802	atpase or kinase
IXO608_RS01585	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO608_RS01590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO608_RS01610	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS01630	COG2081	HI0933 family
IXO608_RS01635	COG4681	YaeQ
IXO608_RS01640	COG1671	Belongs to the UPF0178 family
IXO608_RS01650	COG0625	glutathione transferase activity
IXO608_RS01670	COG0513	Belongs to the DEAD box helicase family
IXO608_RS01675	COG0488	(ABC) transporter
IXO608_RS01695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO608_RS01700	COG0483	inositol monophosphate 1-phosphatase activity
IXO608_RS01715	COG3300	MHYT domain
IXO608_RS01715	COG5001	Diguanylate cyclase
IXO608_RS01735	COG0402	S-adenosylhomocysteine deaminase activity
IXO608_RS01740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO608_RS01765	COG4677	pectinesterase activity
IXO608_RS01775	COG3039	Transposase
IXO608_RS01810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO608_RS01835	COG2166	iron-sulfur cluster assembly
IXO608_RS01850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO608_RS01855	COG0137	argininosuccinate synthase activity
IXO608_RS01865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO608_RS01870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO608_RS01885	COG0165	Argininosuccinate lyase
IXO608_RS01905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO608_RS01955	COG4988	ABC transporter
IXO608_RS01960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO608_RS02035	COG3039	Transposase
IXO608_RS02045	COG3039	Transposase
IXO608_RS02090	COG0643	Histidine kinase
IXO608_RS02090	COG0784	Response regulator, receiver
IXO608_RS02090	COG2198	Histidine kinase
IXO608_RS02145	COG1684	flagellar biosynthetic protein fliR
IXO608_RS02160	COG3190	flagellar
IXO608_RS02210	COG1677	Flagellar hook-basal body complex protein FliE
IXO608_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS02250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO608_RS02270	COG2201	protein-glutamate methylesterase activity
IXO608_RS02305	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO608_RS02310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO608_RS02345	COG4787	bacterial-type flagellum-dependent cell motility
IXO608_RS02355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO608_RS02360	COG1558	bacterial-type flagellum-dependent cell motility
IXO608_RS02370	COG0784	Response regulator, receiver
IXO608_RS02370	COG0835	chemotaxis
IXO608_RS02390	COG5002	protein histidine kinase activity
IXO608_RS02400	COG4585	Histidine kinase
IXO608_RS02405	COG5001	Diguanylate cyclase
IXO608_RS02430	COG0482	sulfurtransferase activity
IXO608_RS02445	COG0542	response to heat
IXO608_RS02480	COG0492	ferredoxin-NADP+ reductase activity
IXO608_RS02485	COG1674	ftsk spoiiie
IXO608_RS02505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO608_RS02525	COG0038	chloride channel
IXO608_RS02530	COG0183	Belongs to the thiolase family
IXO608_RS02535	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO608_RS02535	COG1024	Enoyl-CoA hydratase
IXO608_RS02550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO608_RS02560	COG1426	Protein conserved in bacteria
IXO608_RS02570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_RS02580	COG0303	'Molybdopterin
IXO608_RS02610	COG3039	Transposase
IXO608_RS02620	COG3039	Transposase
IXO608_RS02650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO608_RS02670	COG0742	ribosomal rna small subunit methyltransferase
IXO608_RS02675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO608_RS02685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO608_RS02690	COG0405	Gamma-glutamyltransferase
IXO608_RS02770	COG0343	queuine tRNA-ribosyltransferase activity
IXO608_RS02775	COG1862	Preprotein translocase
IXO608_RS02780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO608_RS02785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO608_RS02795	COG3039	Transposase
IXO608_RS02815	COG3328	transposase activity
IXO608_RS02830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO608_RS02840	COG0704	Plays a role in the regulation of phosphate uptake
IXO608_RS02855	COG0573	inorganic phosphate transmembrane transporter activity
IXO608_RS02860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO608_RS02900	COG3039	Transposase
IXO608_RS02920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO608_RS02930	COG1024	Enoyl-CoA hydratase
IXO608_RS02945	COG0494	nUDIX hydrolase
IXO608_RS02990	COG0116	Belongs to the methyltransferase superfamily
IXO608_RS02990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO608_RS03015	COG0667	Aldo Keto reductase
IXO608_RS03025	COG2925	Exonuclease
IXO608_RS03050	COG0288	reversible hydration of carbon dioxide
IXO608_RS03080	COG0316	Belongs to the HesB IscA family
IXO608_RS03085	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO608_RS03095	COG0359	binds to the 23S rRNA
IXO608_RS03105	COG3115	cell septum assembly
IXO608_RS03125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO608_RS03140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO608_RS03165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO608_RS03175	COG2986	histidine ammonia-lyase
IXO608_RS03180	COG1228	amidohydrolase
IXO608_RS03220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO608_RS03225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IXO608_RS03230	COG1605	Chorismate mutase
IXO608_RS03230	COG0077	Prephenate dehydratase
IXO608_RS03235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO608_RS03265	COG4566	intracellular signal transduction
IXO608_RS03310	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO608_RS03315	COG1469	GTP cyclohydrolase I activity
IXO608_RS03325	COG0617	tRNA 3'-terminal CCA addition
IXO608_RS03370	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO608_RS03385	COG3706	GGDEF domain
IXO608_RS03385	COG5001	Diguanylate cyclase
IXO608_RS03385	COG2203	Gaf domain
IXO608_RS03385	COG4251	negative regulation of phosphorylation
IXO608_RS03470	COG0386	Belongs to the glutathione peroxidase family
IXO608_RS03550	COG0784	Response regulator, receiver
IXO608_RS03550	COG2205	protein histidine kinase activity
IXO608_RS03550	COG5002	protein histidine kinase activity
IXO608_RS03580	COG0800	Aldolase
IXO608_RS03585	COG0129	dihydroxy-acid dehydratase activity
IXO608_RS03590	COG0363	glucosamine-6-phosphate deaminase activity
IXO608_RS03600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO608_RS03615	COG0354	folic acid binding
IXO608_RS03630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO608_RS03645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO608_RS03660	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO608_RS03685	COG0811	peptide transport
IXO608_RS03700	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO608_RS03710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO608_RS03720	COG0322	excinuclease ABC activity
IXO608_RS03755	COG3328	transposase activity
IXO608_RS03775	COG3039	Transposase
IXO608_RS03795	COG2801	Transposase and inactivated derivatives
IXO608_RS03930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO608_RS03930	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO608_RS03940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO608_RS03950	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO608_RS03950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO608_RS03965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO608_RS03985	COG0124	histidyl-tRNA synthetase
IXO608_RS04000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO608_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
IXO608_RS04060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO608_RS04065	COG0697	spore germination
IXO608_RS04090	COG0671	phosphoesterase, PA-phosphatase related
IXO608_RS04105	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO608_RS04120	COG2183	response to ionizing radiation
IXO608_RS04130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_RS04130	COG0723	plastoquinol--plastocyanin reductase activity
IXO608_RS04145	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO608_RS04155	COG1183	phosphatidylcholine synthase activity
IXO608_RS04160	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS04185	COG0668	transmembrane transport
IXO608_RS04205	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO608_RS04230	COG0583	DNA-binding transcription factor activity
IXO608_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS04260	COG0583	DNA-binding transcription factor activity
IXO608_RS04265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO608_RS04270	COG3002	Belongs to the UPF0753 family
IXO608_RS04285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO608_RS04305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO608_RS04315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO608_RS04320	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO608_RS04330	COG0776	regulation of translation
IXO608_RS04335	COG0539	negative regulation of cytoplasmic translation
IXO608_RS04340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO608_RS04355	COG2957	Belongs to the agmatine deiminase family
IXO608_RS04365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO608_RS04390	COG0395	ABC-type sugar transport system, permease component
IXO608_RS04395	COG1175	transmembrane transport
IXO608_RS04425	COG2350	Protein conserved in bacteria
IXO608_RS04430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO608_RS04435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO608_RS04440	COG1187	pseudouridine synthase activity
IXO608_RS04465	COG0436	Aminotransferase
IXO608_RS04530	COG0277	FAD linked oxidase domain protein
IXO608_RS04535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO608_RS04545	COG0531	amino acid
IXO608_RS04550	COG0531	amino acid
IXO608_RS04560	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO608_RS04590	COG2201	protein-glutamate methylesterase activity
IXO608_RS04640	COG0583	DNA-binding transcription factor activity
IXO608_RS04650	COG3039	Transposase
IXO608_RS04700	COG3039	Transposase
IXO608_RS04750	COG3039	Transposase
IXO608_RS04775	COG3328	transposase activity
IXO608_RS04795	COG3039	Transposase
IXO608_RS04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO608_RS04825	COG0557	exoribonuclease II activity
IXO608_RS04850	COG1960	acyl-CoA dehydrogenase activity
IXO608_RS04855	COG2226	methyltransferase
IXO608_RS04860	COG1410	methionine synthase
IXO608_RS04860	COG0646	methionine synthase
IXO608_RS04865	COG1410	methionine synthase
IXO608_RS04865	COG0646	methionine synthase
IXO608_RS04875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_RS04885	COG1609	Transcriptional regulator
IXO608_RS04900	COG2900	Belongs to the SlyX family
IXO608_RS04915	COG0386	Belongs to the glutathione peroxidase family
IXO608_RS04925	COG1725	Transcriptional regulator
IXO608_RS04930	COG1131	(ABC) transporter
IXO608_RS05010	COG2850	peptidyl-arginine hydroxylation
IXO608_RS05045	COG1132	(ABC) transporter
IXO608_RS05070	COG1605	Chorismate mutase
IXO608_RS05070	COG0287	Prephenate dehydrogenase
IXO608_RS05075	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO608_RS05080	COG0484	heat shock protein binding
IXO608_RS05085	COG0443	Heat shock 70 kDa protein
IXO608_RS05090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO608_RS05100	COG0497	DNA recombination
IXO608_RS05110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_RS05115	COG2914	Belongs to the UPF0125 (RnfH) family
IXO608_RS05140	COG1960	acyl-CoA dehydrogenase activity
IXO608_RS05150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO608_RS05195	COG2814	Major facilitator Superfamily
IXO608_RS05200	COG1566	PFAM secretion protein HlyD family protein
IXO608_RS05235	COG4774	siderophore transport
IXO608_RS05245	COG0367	asparagine synthase
IXO608_RS05260	COG1393	Belongs to the ArsC family
IXO608_RS05320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO608_RS05335	COG0233	cytoplasmic translational termination
IXO608_RS05345	COG0575	Belongs to the CDS family
IXO608_RS05355	COG0750	zinc metalloprotease
IXO608_RS05375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO608_RS05380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO608_RS05400	COG0825	malonyl-CoA metabolic process
IXO608_RS05410	COG4771	TonB-dependent receptor
IXO608_RS05415	COG1131	(ABC) transporter
IXO608_RS05445	COG1981	membrane
IXO608_RS05490	COG0529	Catalyzes the synthesis of activated sulfate
IXO608_RS05490	COG2895	sulfate adenylyltransferase (ATP) activity
IXO608_RS05525	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO608_RS05540	COG2040	homocysteine
IXO608_RS05545	COG0833	amino acid
IXO608_RS05565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO608_RS05565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO608_RS05575	COG2878	Part of a membrane complex involved in electron transport
IXO608_RS05590	COG1595	DNA-templated transcription, initiation
IXO608_RS05615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO608_RS05630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO608_RS05635	COG0251	oxidation-reduction process
IXO608_RS05645	COG0392	lysyltransferase activity
IXO608_RS05645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO608_RS05690	COG2814	Major facilitator Superfamily
IXO608_RS05695	COG1902	pentaerythritol trinitrate reductase activity
IXO608_RS05705	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO608_RS05720	COG1047	Peptidyl-prolyl cis-trans
IXO608_RS05755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO608_RS05800	COG0183	Belongs to the thiolase family
IXO608_RS05830	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO608_RS05830	COG1793	dna ligase
IXO608_RS05840	COG1793	dna ligase
IXO608_RS05845	COG1201	RNA secondary structure unwinding
IXO608_RS05875	COG1278	Cold shock
IXO608_RS05880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO608_RS05885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO608_RS05895	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO608_RS05900	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO608_RS05905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO608_RS05920	COG2954	triphosphatase activity
IXO608_RS05935	COG1381	Involved in DNA repair and RecF pathway recombination
IXO608_RS05965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO608_RS05980	COG1024	Enoyl-CoA hydratase
IXO608_RS05980	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO608_RS06000	COG1024	Enoyl-CoA hydratase
IXO608_RS06005	COG1960	acyl-CoA dehydrogenase activity
IXO608_RS06075	COG2353	YceI-like domain
IXO608_RS06085	COG2353	YceI-like domain
IXO608_RS06100	COG1760	l-serine dehydratase
IXO608_RS06110	COG0626	cystathionine gamma-synthase activity
IXO608_RS06115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO608_RS06120	COG0739	heme binding
IXO608_RS06130	COG1272	protein, Hemolysin III
IXO608_RS06155	COG0463	Glycosyl transferase, family 2
IXO608_RS06165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO608_RS06175	COG4771	TonB-dependent receptor
IXO608_RS06180	COG1309	transcriptional regulator
IXO608_RS06190	COG1960	acyl-CoA dehydrogenase activity
IXO608_RS06225	COG0509	glycine decarboxylation via glycine cleavage system
IXO608_RS06240	COG0330	HflC and HflK could
IXO608_RS06255	COG3956	TIGRFAM MazG family protein
IXO608_RS06265	COG0494	nUDIX hydrolase
IXO608_RS06275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO608_RS06280	COG0837	glucose binding
IXO608_RS06295	COG3858	chitin binding
IXO608_RS06295	COG1388	LysM domain
IXO608_RS06305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO608_RS06315	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO608_RS06385	COG3537	Alpha-1,2-mannosidase
IXO608_RS06435	COG3142	Participates in the control of copper homeostasis
IXO608_RS06440	COG1446	asparaginase
IXO608_RS06450	COG2304	oxidoreductase activity
IXO608_RS06455	COG2304	oxidoreductase activity
IXO608_RS06480	COG2198	Histidine kinase
IXO608_RS06480	COG0643	Histidine kinase
IXO608_RS06480	COG0784	Response regulator, receiver
IXO608_RS06485	COG0840	transmembrane signaling receptor activity
IXO608_RS06490	COG0835	chemotaxis
IXO608_RS06505	COG0189	ligase activity
IXO608_RS06515	COG1397	ADP-ribosylglycohydrolase
IXO608_RS06525	COG1199	ATP-dependent helicase activity
IXO608_RS06535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO608_RS06540	COG1215	transferase activity, transferring glycosyl groups
IXO608_RS06550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO608_RS06615	COG1643	Atp-dependent helicase
IXO608_RS06620	COG0783	Belongs to the Dps family
IXO608_RS06625	COG0514	ATP-dependent DNA helicase (RecQ)
IXO608_RS06650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO608_RS06705	COG1187	pseudouridine synthase activity
IXO608_RS06710	COG0602	queuosine metabolic process
IXO608_RS06720	COG2885	chlorophyll binding
IXO608_RS06735	COG0848	biopolymer transport protein
IXO608_RS06745	COG0824	Thioesterase
IXO608_RS06750	COG2255	four-way junction helicase activity
IXO608_RS06760	COG0632	four-way junction helicase activity
IXO608_RS06865	COG3209	COG3209 Rhs family protein
IXO608_RS06865	COG3209	COG3209 Rhs family protein
IXO608_RS06890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO608_RS06895	COG1845	cytochrome c oxidase, subunit III
IXO608_RS06900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO608_RS06915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO608_RS06920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO608_RS06930	COG0196	riboflavin kinase activity
IXO608_RS06935	COG0728	peptidoglycan biosynthetic process
IXO608_RS06940	COG0268	Binds directly to 16S ribosomal RNA
IXO608_RS06945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO608_RS06950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO608_RS06960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO608_RS06965	COG0824	Thioesterase
IXO608_RS06980	COG1946	Acyl-CoA thioesterase
IXO608_RS07005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO608_RS07045	COG1877	trehalose-phosphatase activity
IXO608_RS07050	COG3387	PFAM Glycoside hydrolase 15-related
IXO608_RS07075	COG0564	pseudouridine synthase activity
IXO608_RS07080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_RS07085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO608_RS07085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO608_RS07100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO608_RS07105	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO608_RS07130	COG2184	nucleotidyltransferase activity
IXO608_RS07150	COG2194	sulfuric ester hydrolase activity
IXO608_RS07155	COG4969	Belongs to the N-Me-Phe pilin family
IXO608_RS07165	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO608_RS07200	COG3039	Transposase
IXO608_RS07225	COG3039	Transposase
IXO608_RS07255	COG1132	(ABC) transporter
IXO608_RS07285	COG0745	RESPONSE REGULATOR receiver
IXO608_RS07290	COG5000	phosphorelay sensor kinase activity
IXO608_RS07290	COG5002	protein histidine kinase activity
IXO608_RS07295	COG0475	glutathione-regulated potassium exporter activity
IXO608_RS07305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO608_RS07325	COG1187	pseudouridine synthase activity
IXO608_RS07330	COG5002	protein histidine kinase activity
IXO608_RS07330	COG5001	Diguanylate cyclase
IXO608_RS07390	COG3039	Transposase
IXO608_RS07450	COG0415	Belongs to the DNA photolyase family
IXO608_RS07455	COG0305	Participates in initiation and elongation during chromosome replication
IXO608_RS07465	COG0367	asparagine synthase
IXO608_RS07480	COG1960	acyl-CoA dehydrogenase activity
IXO608_RS07495	COG0084	hydrolase, TatD family'
IXO608_RS07500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO608_RS07560	COG0735	belongs to the Fur family
IXO608_RS07565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO608_RS07595	COG3039	Transposase
IXO608_RS07670	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO608_RS07680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO608_RS07695	COG0643	Histidine kinase
IXO608_RS07695	COG2198	Histidine kinase
IXO608_RS07700	COG0840	transmembrane signaling receptor activity
IXO608_RS07705	COG0835	chemotaxis
IXO608_RS07710	COG2200	EAL domain
IXO608_RS07710	COG2202	Pas domain
IXO608_RS07710	COG2199	diguanylate cyclase activity
IXO608_RS07715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO608_RS07730	COG3590	peptidase
IXO608_RS07750	COG1515	deoxyribonuclease V activity
IXO608_RS07755	COG1741	Belongs to the pirin family
IXO608_RS07860	COG3039	Transposase
IXO608_RS07890	COG1741	Belongs to the pirin family
IXO608_RS07895	COG1966	Carbon starvation protein
IXO608_RS07900	COG2879	small protein
IXO608_RS07935	COG2203	Gaf domain
IXO608_RS07935	COG3706	GGDEF domain
IXO608_RS07935	COG4251	negative regulation of phosphorylation
IXO608_RS07935	COG5001	Diguanylate cyclase
IXO608_RS07940	COG0629	single-stranded DNA binding
IXO608_RS07945	COG0142	geranyltranstransferase activity
IXO608_RS07970	COG0527	aspartate kinase activity
IXO608_RS07980	COG0384	phenazine biosynthesis protein PhzF
IXO608_RS07990	COG1764	response to oxidative stress
IXO608_RS08005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO608_RS08010	COG1678	Uncharacterized ACR, COG1678
IXO608_RS08025	COG0519	Catalyzes the synthesis of GMP from XMP
IXO608_RS08055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO608_RS08115	COG1959	2 iron, 2 sulfur cluster binding
IXO608_RS08120	COG0719	Fe-S assembly protein
IXO608_RS08125	COG0396	ATPase activity
IXO608_RS08130	COG0719	Fe-S assembly protein
IXO608_RS08135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO608_RS08150	COG2146	nitrite reductase [NAD(P)H] activity
IXO608_RS08190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO608_RS08205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO608_RS08215	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO608_RS08220	COG0174	glutamine synthetase
IXO608_RS08225	COG3328	transposase activity
IXO608_RS08250	COG0326	Molecular chaperone. Has ATPase activity
IXO608_RS08255	COG2207	Transcriptional regulator
IXO608_RS08285	COG0657	acetylesterase activity
IXO608_RS08285	COG2755	lipolytic protein G-D-S-L family
IXO608_RS08310	COG0488	(ABC) transporter
IXO608_RS08345	COG4651	solute:proton antiporter activity
IXO608_RS08345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO608_RS08360	COG4772	TonB-dependent receptor
IXO608_RS08370	COG4264	IucA IucC family
IXO608_RS08375	COG2814	Major facilitator Superfamily
IXO608_RS08385	COG0019	diaminopimelate decarboxylase activity
IXO608_RS08450	COG4206	TonB-dependent receptor
IXO608_RS08485	COG0542	response to heat
IXO608_RS08525	COG0534	Mate efflux family protein
IXO608_RS08540	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO608_RS08545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO608_RS08550	COG0228	four-way junction DNA binding
IXO608_RS08570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO608_RS08580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO608_RS08585	COG3039	Transposase
IXO608_RS08630	COG1555	photosystem II stabilization
IXO608_RS08635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO608_RS08650	COG3178	'Phosphotransferase
IXO608_RS08655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO608_RS08665	COG0628	permease
IXO608_RS08675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO608_RS08690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO608_RS08710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO608_RS08715	COG0271	Belongs to the BolA IbaG family
IXO608_RS08725	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO608_RS08735	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO608_RS08740	COG1137	ATPase activity
IXO608_RS08755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO608_RS08760	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO608_RS08765	COG1660	Displays ATPase and GTPase activities
IXO608_RS08775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO608_RS08780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO608_RS08785	COG2239	Acts as a magnesium transporter
IXO608_RS08795	COG1294	oxidase, subunit
IXO608_RS08800	COG1271	oxidase subunit
IXO608_RS08815	COG1113	amino acid transport
IXO608_RS08830	COG2197	response regulator
IXO608_RS08835	COG0531	amino acid
IXO608_RS08895	COG0754	glutathionylspermidine amidase activity
IXO608_RS08920	COG1842	Phage shock protein A
IXO608_RS08935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO608_RS08980	COG2201	protein-glutamate methylesterase activity
IXO608_RS09020	COG2801	Transposase and inactivated derivatives
IXO608_RS09085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO608_RS09090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO608_RS09135	COG0745	RESPONSE REGULATOR receiver
IXO608_RS09140	COG2205	protein histidine kinase activity
IXO608_RS09160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO608_RS09190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO608_RS09190	COG3453	Protein conserved in bacteria
IXO608_RS09195	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO608_RS09200	COG4149	molybdate abc transporter
IXO608_RS09205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO608_RS09225	COG0642	Histidine kinase
IXO608_RS09240	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS09250	COG1022	Amp-dependent synthetase and ligase
IXO608_RS09275	COG1376	ErfK ybiS ycfS ynhG family protein
IXO608_RS09280	COG0739	heme binding
IXO608_RS09290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO608_RS09295	COG1301	dicarboxylic acid transport
IXO608_RS09315	COG2304	oxidoreductase activity
IXO608_RS09335	COG0714	Associated with various cellular activities
IXO608_RS09385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO608_RS09410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO608_RS09420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO608_RS09445	COG1561	YicC-like family, N-terminal region
IXO608_RS09450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO608_RS09465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO608_RS09505	COG0006	proline dipeptidase activity
IXO608_RS09530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO608_RS09550	COG2912	Transglutaminase-like superfamily
IXO608_RS09555	COG1773	rubredoxin
IXO608_RS09560	COG0352	thiamine-phosphate diphosphorylase activity
IXO608_RS09590	COG0280	phosphate acetyltransferase
IXO608_RS09590	COG0281	malic enzyme
IXO608_RS09610	COG4191	Histidine kinase
IXO608_RS09625	COG0583	DNA-binding transcription factor activity
IXO608_RS09645	COG2197	response regulator
IXO608_RS09655	COG0642	Histidine kinase
IXO608_RS09670	COG2851	Citrate transporter
IXO608_RS09675	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS09680	COG1609	Transcriptional regulator
IXO608_RS09690	COG2211	Major facilitator Superfamily
IXO608_RS09740	COG0726	polysaccharide deacetylase
IXO608_RS09745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO608_RS09770	COG3039	Transposase
IXO608_RS09815	COG0242	peptide deformylase activity
IXO608_RS09835	COG0714	Associated with various cellular activities
IXO608_RS09855	COG0537	adenosine 5'-monophosphoramidase activity
IXO608_RS09885	COG0314	molybdopterin synthase activity
IXO608_RS09890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO608_RS09895	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO608_RS09905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO608_RS09910	COG1234	tRNA 3'-trailer cleavage
IXO608_RS09915	COG3642	lipopolysaccharide core region biosynthetic process
IXO608_RS09920	COG0859	PFAM glycosyl transferase family 9
IXO608_RS09930	COG0582	viral genome integration into host DNA
IXO608_RS10020	COG0631	protein serine/threonine phosphatase activity
IXO608_RS10030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO608_RS10055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO608_RS10095	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO608_RS10145	COG0473	3-isopropylmalate dehydrogenase activity
IXO608_RS10170	COG0584	glycerophosphoryl diester phosphodiesterase
IXO608_RS10190	COG3039	Transposase
IXO608_RS10320	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO608_RS10340	COG1217	gtp-binding protein TYPA
IXO608_RS10345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO608_RS10350	COG0039	L-malate dehydrogenase activity
IXO608_RS10355	COG0625	glutathione transferase activity
IXO608_RS10370	COG3781	membrane
IXO608_RS10380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO608_RS10410	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO608_RS10430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO608_RS10455	COG3710	Transcriptional regulator
IXO608_RS10460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO608_RS10470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO608_RS10505	COG0066	3-isopropylmalate dehydratase activity
IXO608_RS10510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO608_RS10530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO608_RS10535	COG1538	Outer membrane efflux protein
IXO608_RS10540	COG1519	Transferase
IXO608_RS10545	COG1560	Kdo2-lipid A biosynthetic process
IXO608_RS10595	COG0308	aminopeptidase N
IXO608_RS10610	COG0330	HflC and HflK could
IXO608_RS10615	COG0330	HflC and HflK could
IXO608_RS10635	COG0678	peroxiredoxin activity
IXO608_RS10645	COG2826	transposase and inactivated derivatives, IS30 family
IXO608_RS10695	COG3039	Transposase
IXO608_RS10725	COG3829	transcription factor binding
IXO608_RS10760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO608_RS10765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO608_RS10775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO608_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS10805	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO608_RS10845	COG1518	maintenance of DNA repeat elements
IXO608_RS10850	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO608_RS10895	COG2188	Transcriptional regulator
IXO608_RS10910	COG1450	Type ii and iii secretion system protein
IXO608_RS10925	COG3166	PFAM Fimbrial assembly family protein
IXO608_RS10930	COG3156	type II secretion system protein K
IXO608_RS10935	COG4795	General secretion pathway protein
IXO608_RS10940	COG2165	general secretion pathway protein
IXO608_RS10945	COG4970	Tfp pilus assembly protein FimT
IXO608_RS10950	COG2165	general secretion pathway protein
IXO608_RS10955	COG1459	type II secretion system
IXO608_RS10965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO608_RS10985	COG5295	Hep Hag repeat protein
IXO608_RS10995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO608_RS11000	COG4974	Belongs to the 'phage' integrase family
IXO608_RS11015	COG0795	lipopolysaccharide-transporting ATPase activity
IXO608_RS11025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO608_RS11040	COG0525	valine-tRNA ligase activity
IXO608_RS11095	COG3039	Transposase
IXO608_RS11120	COG1183	phosphatidylcholine synthase activity
IXO608_RS11130	COG0442	prolyl-tRNA aminoacylation
IXO608_RS11145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO608_RS11150	COG1127	ABC transporter
IXO608_RS11155	COG3218	ABC-type transport auxiliary lipoprotein component
IXO608_RS11155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO608_RS11190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO608_RS11195	COG0662	Cupin 2, conserved barrel domain protein
IXO608_RS11195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO608_RS11220	COG2086	electron transfer activity
IXO608_RS11245	COG3328	transposase activity
IXO608_RS11285	COG0626	cystathionine gamma-synthase activity
IXO608_RS11325	COG0513	Belongs to the DEAD box helicase family
IXO608_RS11330	COG0720	synthase
IXO608_RS11340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO608_RS11345	COG1956	GAF domain-containing protein
IXO608_RS11380	COG0339	signal peptide processing
IXO608_RS11435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO608_RS11440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO608_RS11495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO608_RS11500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO608_RS11505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO608_RS11515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO608_RS11525	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO608_RS11545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO608_RS11555	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO608_RS11585	COG2011	ABC-type metal ion transport system permease component
IXO608_RS11595	COG0697	spore germination
IXO608_RS11630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO608_RS11635	COG1187	pseudouridine synthase activity
IXO608_RS11640	COG2813	Specifically methylates the guanine in position
IXO608_RS11670	COG2202	Pas domain
IXO608_RS11670	COG2205	protein histidine kinase activity
IXO608_RS11695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_RS11745	COG0745	RESPONSE REGULATOR receiver
IXO608_RS11760	COG1404	Belongs to the peptidase S8 family
IXO608_RS11780	COG0842	Transport permease protein
IXO608_RS11785	COG1131	(ABC) transporter
IXO608_RS11790	COG0025	NhaP-type Na H and K H
IXO608_RS11800	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO608_RS11810	COG1573	uracil-dna glycosylase
IXO608_RS11820	COG3384	dioxygenase
IXO608_RS11835	COG0667	Aldo Keto reductase
IXO608_RS11850	COG3590	peptidase
IXO608_RS11870	COG0531	amino acid
IXO608_RS11885	COG2972	Histidine kinase
IXO608_RS11915	COG2204	response regulator
IXO608_RS11925	COG1271	oxidase subunit
IXO608_RS11930	COG1294	oxidase, subunit
IXO608_RS12080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO608_RS12090	COG1560	Kdo2-lipid A biosynthetic process
IXO608_RS12140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO608_RS12140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO608_RS12145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO608_RS12150	COG0242	peptide deformylase activity
IXO608_RS12155	COG1652	LysM domain
IXO608_RS12160	COG0758	DNA mediated transformation
IXO608_RS12165	COG2922	Belongs to the Smg family
IXO608_RS12180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO608_RS12180	COG1754	DNA topoisomerase type I activity
IXO608_RS12185	COG0009	L-threonylcarbamoyladenylate synthase
IXO608_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS12210	COG0616	signal peptide processing
IXO608_RS12215	COG0534	Mate efflux family protein
IXO608_RS12235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO608_RS12270	COG1324	tolerance protein
IXO608_RS12280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO608_RS12285	COG0511	ligase activity, forming carbon-carbon bonds
IXO608_RS12295	COG0439	Biotin carboxylase
IXO608_RS12335	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO608_RS12370	COG0419	ATPase involved in DNA repair
IXO608_RS12380	COG0151	Belongs to the GarS family
IXO608_RS12385	COG0577	efflux transmembrane transporter activity
IXO608_RS12385	COG1136	(ABC) transporter
IXO608_RS12395	COG1289	transmembrane transporter activity
IXO608_RS12410	COG2814	Major facilitator Superfamily
IXO608_RS12425	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO608_RS12460	COG0745	RESPONSE REGULATOR receiver
IXO608_RS12505	COG0739	heme binding
IXO608_RS12520	COG2211	Major facilitator Superfamily
IXO608_RS12525	COG0708	Exodeoxyribonuclease III
IXO608_RS12540	COG1192	Involved in chromosome partitioning
IXO608_RS12545	COG1475	DNA binding
IXO608_RS12560	COG0463	Glycosyl transferase, family 2
IXO608_RS12585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO608_RS12610	COG4221	oxidoreductase activity
IXO608_RS12635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO608_RS12640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO608_RS12655	COG3485	protocatechuate 3,4-dioxygenase
IXO608_RS12660	COG3485	protocatechuate 3,4-dioxygenase
IXO608_RS12695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO608_RS12700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO608_RS12710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO608_RS12710	COG1042	CoA-binding domain protein
IXO608_RS12710	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO608_RS12725	COG2239	Acts as a magnesium transporter
IXO608_RS12740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO608_RS12745	COG3387	PFAM Glycoside hydrolase 15-related
IXO608_RS12760	COG3100	YcgL domain-containing protein
IXO608_RS12765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO608_RS12775	COG0463	Glycosyl transferase, family 2
IXO608_RS12790	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS12800	COG0156	8-amino-7-oxononanoate synthase activity
IXO608_RS12805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO608_RS12810	COG1040	competence protein
IXO608_RS12815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO608_RS12825	COG0628	permease
IXO608_RS12835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO608_RS12845	COG1595	DNA-templated transcription, initiation
IXO608_RS12850	COG0753	catalase activity
IXO608_RS12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO608_RS12900	COG0180	Tryptophanyl-tRNA synthetase
IXO608_RS12905	COG3237	CsbD-like
IXO608_RS12940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO608_RS12955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO608_RS12960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO608_RS12960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO608_RS12970	COG3228	Belongs to the MtfA family
IXO608_RS13000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO608_RS13035	COG1199	ATP-dependent helicase activity
IXO608_RS13075	COG0583	DNA-binding transcription factor activity
IXO608_RS13120	COG0625	glutathione transferase activity
IXO608_RS13160	COG4555	ABC transporter
IXO608_RS13170	COG1476	TRANSCRIPTIONal
IXO608_RS13190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO608_RS13195	COG1131	(ABC) transporter
IXO608_RS13200	COG0842	Transport permease protein
IXO608_RS13210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO608_RS13280	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO608_RS13290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO608_RS13300	COG0564	pseudouridine synthase activity
IXO608_RS13330	COG0339	signal peptide processing
IXO608_RS13360	COG3254	rhamnose metabolic process
IXO608_RS13365	COG0738	Major facilitator superfamily
IXO608_RS13370	COG1414	Transcriptional regulator
IXO608_RS13380	COG2205	protein histidine kinase activity
IXO608_RS13390	COG3459	Glycosyltransferase 36 associated
IXO608_RS13395	COG2211	Major facilitator Superfamily
IXO608_RS13400	COG3265	gluconokinase activity
IXO608_RS13410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_RS13485	COG1127	ABC transporter
IXO608_RS13490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO608_RS13495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO608_RS13510	COG2853	Lipoprotein
IXO608_RS13530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO608_RS13595	COG0676	glucose-6-phosphate 1-epimerase activity
IXO608_RS13600	COG3039	Transposase
IXO608_RS13625	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_RS13635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_RS13645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_RS13650	COG1064	alcohol dehydrogenase
IXO608_RS13695	COG1522	sequence-specific DNA binding
IXO608_RS13700	COG3186	Phenylalanine-4-hydroxylase
IXO608_RS13740	COG2937	Belongs to the GPAT DAPAT family
IXO608_RS13775	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO608_RS13780	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO608_RS13785	COG3132	Protein of unknown function, DUF480
IXO608_RS13800	COG0210	DNA helicase
IXO608_RS13815	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO608_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS13865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO608_RS13930	COG1166	arginine decarboxylase activity
IXO608_RS13935	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO608_RS13975	COG0606	chelatase, subunit chli
IXO608_RS14020	COG0366	Alpha amylase catalytic
IXO608_RS14025	COG0366	Alpha amylase catalytic
IXO608_RS14050	COG1609	Transcriptional regulator
IXO608_RS14095	COG2032	superoxide dismutase activity
IXO608_RS14100	COG2032	superoxide dismutase activity
IXO608_RS14105	COG2204	response regulator
IXO608_RS14110	COG3852	Histidine kinase
IXO608_RS14115	COG0004	ammonium transporteR
IXO608_RS14120	COG0347	Belongs to the P(II) protein family
IXO608_RS14125	COG0174	glutamine synthetase
IXO608_RS14130	COG1968	undecaprenyl-diphosphatase activity
IXO608_RS14170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO608_RS14180	COG2062	phosphohistidine phosphatase, SixA
IXO608_RS14185	COG0489	protein tyrosine kinase activity
IXO608_RS14205	COG1396	sequence-specific DNA binding
IXO608_RS14210	COG3550	peptidyl-serine autophosphorylation
IXO608_RS14215	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO608_RS14220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO608_RS14235	COG1125	glycine betaine transport
IXO608_RS14235	COG0517	IMP dehydrogenase activity
IXO608_RS14250	COG1119	ATPase activity
IXO608_RS14260	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO608_RS14275	COG3039	Transposase
IXO608_RS14300	COG0656	L-ascorbic acid biosynthetic process
IXO608_RS14305	COG2130	NADP-dependent
IXO608_RS14310	COG0667	Aldo Keto reductase
IXO608_RS14320	COG1187	pseudouridine synthase activity
IXO608_RS14335	COG1643	Atp-dependent helicase
IXO608_RS14340	COG4807	Protein conserved in bacteria
IXO608_RS14345	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_RS14350	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO608_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS14415	COG3162	membrane
IXO608_RS14420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO608_RS14435	COG0708	Exodeoxyribonuclease III
IXO608_RS14450	COG2091	lysine biosynthetic process via aminoadipic acid
IXO608_RS14460	COG3540	Alkaline phosphatase
IXO608_RS14510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO608_RS14515	COG0583	DNA-binding transcription factor activity
IXO608_RS14520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO608_RS14535	COG0210	DNA helicase
IXO608_RS14550	COG0531	amino acid
IXO608_RS14560	COG1322	Protein conserved in bacteria
IXO608_RS14570	COG0386	Belongs to the glutathione peroxidase family
IXO608_RS14620	COG0793	Belongs to the peptidase S41A family
IXO608_RS14625	COG4942	peptidase
IXO608_RS14635	COG2234	aminopeptidase activity
IXO608_RS14680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO608_RS14685	COG0302	gtp cyclohydrolase
IXO608_RS14710	COG0477	Major facilitator Superfamily
IXO608_RS14815	COG1929	Belongs to the glycerate kinase type-1 family
IXO608_RS14820	COG2271	Major facilitator Superfamily
IXO608_RS14835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO608_RS14840	COG0861	Integral membrane protein TerC family
IXO608_RS14850	COG0584	glycerophosphoryl diester phosphodiesterase
IXO608_RS14860	COG0671	phosphoesterase, PA-phosphatase related
IXO608_RS14870	COG0726	polysaccharide deacetylase
IXO608_RS14890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO608_RS14905	COG0187	DNA topoisomerase II activity
IXO608_RS14915	COG0501	Belongs to the peptidase M48B family
IXO608_RS14955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO608_RS14965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO608_RS14975	COG4772	TonB-dependent receptor
IXO608_RS14990	COG3039	Transposase
IXO608_RS14995	COG1304	FMN binding
IXO608_RS15000	COG1755	Isoprenylcysteine carboxyl methyltransferase
IXO608_RS15025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_RS15035	COG3039	Transposase
IXO608_RS15045	COG1136	(ABC) transporter
IXO608_RS15090	COG3039	Transposase
IXO608_RS15095	COG0513	Belongs to the DEAD box helicase family
IXO608_RS15180	COG1858	cytochrome C peroxidase
IXO608_RS15195	COG0702	epimerase
IXO608_RS15220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO608_RS15240	COG1649	PFAM Uncharacterised BCR, COG1649
IXO608_RS15245	COG2354	Protein conserved in bacteria
IXO608_RS15250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO608_RS15265	COG1511	domain protein
IXO608_RS15265	COG3264	Mechanosensitive ion channel
IXO608_RS15340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO608_RS15450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO608_RS15470	COG1090	epimerase
IXO608_RS15500	COG2826	transposase and inactivated derivatives, IS30 family
IXO608_RS15565	COG1136	(ABC) transporter
IXO608_RS15610	COG1272	protein, Hemolysin III
IXO608_RS15615	COG1111	helicase
IXO608_RS15615	COG1205	dead DEAH box helicase
IXO608_RS15675	COG0067	glutamate synthase
IXO608_RS15675	COG0069	glutamate synthase activity
IXO608_RS15675	COG0070	glutamate synthase
IXO608_RS15680	COG0493	'glutamate synthase
IXO608_RS15720	COG1196	nuclear chromosome segregation
IXO608_RS15735	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO608_RS15740	COG1074	ATP-dependent DNA helicase activity
IXO608_RS15750	COG3549	Plasmid maintenance system killer
IXO608_RS15830	COG1764	response to oxidative stress
IXO608_RS15835	COG1846	Transcriptional regulator
IXO608_RS15925	COG2211	Major facilitator Superfamily
IXO608_RS15950	COG3693	PFAM glycoside hydrolase, family 10
IXO608_RS15975	COG0246	Mannitol dehydrogenase
IXO608_RS15980	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO608_RS15990	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_RS16000	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO608_RS16050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO608_RS16060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO608_RS16070	COG0805	protein transport
IXO608_RS16080	COG0519	Catalyzes the synthesis of GMP from XMP
IXO608_RS16080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO608_RS16095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO608_RS16110	COG0457	Tetratricopeptide repeat
IXO608_RS16115	COG4771	TonB-dependent receptor
IXO608_RS16140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO608_RS16160	COG0523	cobalamin synthesis protein
IXO608_RS16215	COG1960	acyl-CoA dehydrogenase activity
IXO608_RS16220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO608_RS16225	COG4770	biotin carboxylase activity
IXO608_RS16300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO608_RS16350	COG0084	hydrolase, TatD family'
IXO608_RS16365	COG0583	DNA-binding transcription factor activity
IXO608_RS16370	COG2814	Major facilitator Superfamily
IXO608_RS16380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO608_RS16385	COG1902	pentaerythritol trinitrate reductase activity
IXO608_RS16415	COG0745	RESPONSE REGULATOR receiver
IXO608_RS16435	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO608_RS16440	COG0583	DNA-binding transcription factor activity
IXO608_RS16470	COG0702	epimerase
IXO608_RS16475	COG1733	regulation of RNA biosynthetic process
IXO608_RS16530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO608_RS16580	COG2911	Protein conserved in bacteria
IXO608_RS16585	COG0729	surface antigen
IXO608_RS16600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO608_RS16605	COG3118	belongs to the thioredoxin family
IXO608_RS16615	COG2884	Cell division ATP-binding protein ftsE
IXO608_RS16620	COG2177	Part of the ABC transporter FtsEX involved in
IXO608_RS16625	COG2201	protein-glutamate methylesterase activity
IXO608_RS16630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO608_RS16635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO608_RS16645	COG1252	NADH dehydrogenase
IXO608_RS16670	COG0459	protein refolding
IXO608_RS16690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO608_RS16720	COG3386	PFAM SMP-30 Gluconolaconase
IXO608_RS16735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO608_RS16765	COG2353	YceI-like domain
IXO608_RS16860	COG0408	coproporphyrinogen oxidase activity
IXO608_RS16870	COG3039	Transposase
IXO608_RS16890	COG0129	dihydroxy-acid dehydratase activity
IXO608_RS16900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO608_RS16950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO608_RS16955	COG0318	PFAM AMP-dependent synthetase and ligase
IXO608_RS16960	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO608_RS16965	COG0596	Alpha beta hydrolase
IXO608_RS16980	COG3177	Filamentation induced by cAMP protein fic
IXO608_RS16985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO608_RS17000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO608_RS17025	COG4191	Histidine kinase
IXO608_RS17030	COG0028	Belongs to the TPP enzyme family
IXO608_RS17045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO608_RS17050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO608_RS17085	COG5383	Protein conserved in bacteria
IXO608_RS17095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO608_RS17100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO608_RS17105	COG1473	amidohydrolase
IXO608_RS17115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO608_RS17115	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO608_RS17125	COG3328	transposase activity
IXO608_RS17135	COG3039	Transposase
IXO608_RS17210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO608_RS17225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO608_RS17230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO608_RS17240	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO608_RS17245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO608_RS17250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO608_RS17300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO608_RS17315	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO608_RS17380	COG0358	DNA primase activity
IXO608_RS17385	COG1295	ribonuclease BN
IXO608_RS17395	COG1610	YqeY-like protein
IXO608_RS17405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO608_RS17410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO608_RS17445	COG2133	pyrroloquinoline quinone binding
IXO608_RS17450	COG4682	membrane
IXO608_RS17485	COG0531	amino acid
IXO608_RS17520	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_RS17530	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO608_RS17535	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO608_RS17565	COG3039	Transposase
IXO608_RS17615	COG0183	Belongs to the thiolase family
IXO608_RS17660	COG3483	tryptophan 2,3-dioxygenase activity
IXO608_RS17665	COG3104	oligopeptide transport
IXO608_RS17685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO608_RS17700	COG1320	monovalent cation:proton antiporter activity
IXO608_RS17705	COG2212	antiporter activity
IXO608_RS17715	COG0651	ATP synthesis coupled electron transport
IXO608_RS17720	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO608_RS17725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO608_RS17725	COG2111	Na H antiporter
IXO608_RS17755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO608_RS17765	COG0456	acetyltransferase
IXO608_RS17795	COG4221	oxidoreductase activity
IXO608_RS17855	COG0697	spore germination
IXO608_RS17860	COG4305	rare lipoprotein A
IXO608_RS17865	COG5297	Belongs to the glycosyl hydrolase family 6
IXO608_RS17875	COG1113	amino acid transport
IXO608_RS17885	COG0598	Magnesium transport protein CorA
IXO608_RS17955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_RS17955	COG5297	Belongs to the glycosyl hydrolase family 6
IXO608_RS17960	COG0659	secondary active sulfate transmembrane transporter activity
IXO608_RS17995	COG3275	phosphorelay sensor kinase activity
IXO608_RS18005	COG0181	hydroxymethylbilane synthase activity
IXO608_RS18030	COG1505	serine-type exopeptidase activity
IXO608_RS18045	COG0436	Aminotransferase
IXO608_RS18075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO608_RS18105	COG0308	aminopeptidase N
IXO608_RS18110	COG2199	diguanylate cyclase activity
IXO608_RS18155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_RS18160	COG1077	Cell shape determining protein MreB Mrl
IXO608_RS18165	COG1792	Involved in formation and maintenance of cell shape
IXO608_RS18180	COG0772	Belongs to the SEDS family
IXO608_RS18220	COG1388	LysM domain
IXO608_RS18220	COG3409	Peptidoglycan-binding domain 1 protein
IXO608_RS18220	COG5632	N-Acetylmuramoyl-L-alanine amidase
IXO608_RS18240	COG2951	lytic endotransglycosylase activity
IXO608_RS18245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO608_RS18250	COG1686	Belongs to the peptidase S11 family
IXO608_RS18265	COG2921	Belongs to the UPF0250 family
IXO608_RS18305	COG1051	belongs to the nudix hydrolase family
IXO608_RS18305	COG1056	cytidyltransferase-related domain
IXO608_RS18340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO608_RS18345	COG0673	inositol 2-dehydrogenase activity
IXO608_RS18350	COG2823	Periplasmic or secreted lipoprotein
IXO608_RS18355	COG4251	negative regulation of phosphorylation
IXO608_RS18360	COG0784	Response regulator, receiver
IXO608_RS18365	COG4191	Histidine kinase
IXO608_RS18370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO608_RS18420	COG3250	beta-galactosidase activity
IXO608_RS18435	COG2188	Transcriptional regulator
IXO608_RS18445	COG1609	Transcriptional regulator
IXO608_RS18450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO608_RS18455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO608_RS18465	COG1215	transferase activity, transferring glycosyl groups
IXO608_RS18470	COG0726	polysaccharide deacetylase
IXO608_RS18470	COG1649	PFAM Uncharacterised BCR, COG1649
IXO608_RS18540	COG3039	Transposase
IXO608_RS18550	COG3039	Transposase
IXO608_RS18560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO608_RS18565	COG3039	Transposase
IXO608_RS18600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO608_RS18655	COG2205	protein histidine kinase activity
IXO608_RS18680	COG3791	Glutathione-dependent formaldehyde-activating
IXO608_RS18705	COG0488	(ABC) transporter
IXO608_RS18725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO608_RS18745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO608_RS18745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO608_RS18765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO608_RS18770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO608_RS18775	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO608_RS18795	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO608_RS18800	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO608_RS18810	COG2205	protein histidine kinase activity
IXO608_RS18815	COG0745	RESPONSE REGULATOR receiver
IXO608_RS18820	COG0277	FAD linked oxidase domain protein
IXO608_RS18825	COG1988	membrane-bound metal-dependent
IXO608_RS18830	COG0792	nuclease activity
IXO608_RS18865	COG0275	rRNA processing
IXO608_RS18870	COG3116	cell division
IXO608_RS18885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO608_RS18890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO608_RS18905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO608_RS18910	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO608_RS18915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO608_RS18930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO608_RS18940	COG1388	LysM domain
IXO608_RS18940	COG4942	peptidase
IXO608_RS18955	COG0494	nUDIX hydrolase
IXO608_RS18970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO608_RS18980	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_RS18980	COG3321	synthase
IXO608_RS18980	COG0604	alcohol dehydrogenase
IXO608_RS19035	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO608_RS19080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO608_RS19095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO608_RS19105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_RS19110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO608_RS19120	COG0667	Aldo Keto reductase
IXO608_RS19170	COG2175	clavaminate synthase activity
IXO608_RS19180	COG4181	ATPase activity
IXO608_RS19195	COG0642	Histidine kinase
IXO608_RS19215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO608_RS19235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO608_RS19260	COG2967	ApaG domain
IXO608_RS19265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO608_RS19275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO608_RS19290	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO608_RS19295	COG2096	Adenosyltransferase
IXO608_RS19305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO608_RS19310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO608_RS19350	COG0583	DNA-binding transcription factor activity
IXO608_RS19355	COG0318	PFAM AMP-dependent synthetase and ligase
IXO608_RS19365	COG1024	Enoyl-CoA hydratase
IXO608_RS19385	COG3386	PFAM SMP-30 Gluconolaconase
IXO608_RS19435	COG3039	Transposase
IXO608_RS19520	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO608_RS19520	COG1902	pentaerythritol trinitrate reductase activity
IXO608_RS19525	COG0604	alcohol dehydrogenase
IXO608_RS19550	COG0156	8-amino-7-oxononanoate synthase activity
IXO608_RS19555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO608_RS19560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO608_RS19565	COG4208	sulfate ABC transporter
IXO608_RS19570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO608_RS19600	COG0588	phosphoglycerate mutase activity
IXO608_RS19610	COG0285	dihydrofolate synthase activity
IXO608_RS19630	COG2833	Protein of unknown function (DUF455)
IXO608_RS19650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO608_RS19655	COG0671	phosphoesterase, PA-phosphatase related
IXO608_RS19660	COG0438	transferase activity, transferring glycosyl groups
IXO608_RS19670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO608_RS19685	COG4783	chaperone-mediated protein folding
IXO608_RS19750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO608_RS19755	COG0583	DNA-binding transcription factor activity
IXO608_RS19760	COG3634	alkyl hydroperoxide reductase activity
IXO608_RS19770	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO608_RS19820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO608_RS19820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO608_RS19835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO608_RS19860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO608_RS19885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO608_RS19895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO608_RS19925	COG1295	ribonuclease BN
IXO608_RS19930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO608_RS19950	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO608_RS19960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO608_RS19975	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO608_RS19990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO608_RS20000	COG0193	aminoacyl-tRNA hydrolase activity
IXO608_RS20005	COG0012	GTP binding
IXO608_RS20035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO608_RS20040	COG0250	Participates in transcription elongation, termination and antitermination
IXO608_RS20045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO608_RS20055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO608_RS20060	COG0222	ribosome binding
IXO608_RS20065	COG0085	RNA polymerase activity
IXO608_RS20070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO608_RS20075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO608_RS20080	COG0049	tRNA binding
IXO608_RS20100	COG0051	transcription antitermination factor activity, RNA binding
IXO608_RS20105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO608_RS20110	COG0088	Forms part of the polypeptide exit tunnel
IXO608_RS20115	COG0089	rRNA binding
IXO608_RS20130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO608_RS20140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO608_RS20145	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO608_RS20150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO608_RS20155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO608_RS20165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO608_RS20195	COG1841	ribosomal large subunit assembly
IXO608_RS20205	COG0201	protein transport
IXO608_RS20215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO608_RS20220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO608_RS20230	COG0203	ribosomal protein L17
IXO608_RS20290	COG3551	Protein conserved in bacteria
IXO608_RS20320	COG2194	sulfuric ester hydrolase activity
IXO608_RS20330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO608_RS20335	COG0745	RESPONSE REGULATOR receiver
IXO608_RS20340	COG0642	Histidine kinase
IXO608_RS20350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO608_RS20355	COG2894	cell division
IXO608_RS20370	COG4585	Histidine kinase
IXO608_RS20375	COG2197	response regulator
IXO608_RS20390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO608_RS20525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO608_RS20740	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO608_RS20760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO608_RS20765	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO608_RS20770	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO608_RS20780	COG0732	type I restriction modification DNA specificity domain
IXO608_RS20795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO608_RS20890	COG1297	OPT oligopeptide transporter protein
IXO608_RS20915	COG0823	Involved in the tonB-independent uptake of proteins
IXO608_RS20915	COG1506	peptidase
IXO608_RS20945	COG1917	Cupin 2, conserved barrel domain protein
IXO608_RS20945	COG2207	Transcriptional regulator
IXO608_RS20965	COG3039	Transposase
IXO608_RS20985	COG0753	catalase activity
IXO608_RS21025	COG0469	pyruvate kinase activity
IXO608_RS21030	COG3588	fructose-bisphosphate aldolase
IXO608_RS21035	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO608_RS21085	COG2205	protein histidine kinase activity
IXO608_RS21085	COG2198	Histidine kinase
IXO608_RS21085	COG0784	Response regulator, receiver
IXO608_RS21105	COG0175	sulfate reduction
IXO608_RS21110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO608_RS21115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO608_RS21120	COG0175	sulfate reduction
IXO608_RS21125	COG0529	Catalyzes the synthesis of activated sulfate
IXO608_RS21125	COG2895	sulfate adenylyltransferase (ATP) activity
IXO608_RS21135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO608_RS21140	COG0308	aminopeptidase N
IXO608_RS21160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO608_RS21165	COG2272	Belongs to the type-B carboxylesterase lipase family
IXO608_RS21185	COG1970	mechanosensitive ion channel activity
IXO608_RS21215	COG3273	potassium ion transport
IXO608_RS21215	COG0471	metal ion transport
IXO608_RS21225	COG2022	thiamine diphosphate biosynthetic process
IXO608_RS21305	COG3039	Transposase
IXO608_RS21310	COG3039	Transposase
IXO608_RS21380	COG3118	belongs to the thioredoxin family
IXO608_RS21405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO608_RS21425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO608_RS21450	COG2968	Membrane
IXO608_RS21465	COG3164	Protein of unknown function
IXO608_RS21475	COG0312	modulator of DNA gyrase
IXO608_RS21480	COG3028	Belongs to the UPF0307 family
IXO608_RS21485	COG0312	modulator of DNA gyrase
IXO608_RS21510	COG0142	geranyltranstransferase activity
IXO608_RS21515	COG1722	exodeoxyribonuclease VII activity
IXO608_RS21520	COG0037	tRNA processing
IXO608_RS21525	COG1785	Belongs to the alkaline phosphatase family
IXO608_RS21545	COG0791	NLP P60 protein
IXO608_RS21550	COG0791	NLP P60 protein
IXO608_RS21555	COG1047	Peptidyl-prolyl cis-trans
IXO608_RS21560	COG2311	Membrane
IXO608_RS21565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_RS21605	COG0489	protein tyrosine kinase activity
IXO608_RS21610	COG0717	Belongs to the dCTP deaminase family
IXO608_RS21640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO608_RS21650	COG3039	Transposase
IXO608_RS21685	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO608_RS21690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO608_RS21695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO608_RS21700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO608_RS21720	COG0101	tRNA pseudouridine synthase activity
IXO608_RS21725	COG0135	phosphoribosylanthranilate isomerase activity
IXO608_RS21750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO608_RS21755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO608_RS21805	COG0149	triose-phosphate isomerase activity
IXO608_RS21820	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO608_RS21830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO608_RS21835	COG0649	NAD binding
IXO608_RS21840	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO608_RS21845	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO608_RS21850	COG1034	ATP synthesis coupled electron transport
IXO608_RS21885	COG1007	ATP synthesis coupled electron transport
IXO608_RS21895	COG0779	Required for maturation of 30S ribosomal subunits
IXO608_RS21900	COG0195	Participates in both transcription termination and antitermination
IXO608_RS21920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO608_RS21925	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO608_RS21960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO608_RS21970	COG2095	MarC family integral membrane protein
IXO608_RS21985	COG1611	Belongs to the LOG family
IXO608_RS22025	COG4969	Belongs to the N-Me-Phe pilin family
IXO608_RS22065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO608_RS22135	COG0438	transferase activity, transferring glycosyl groups
IXO608_RS22140	COG0438	transferase activity, transferring glycosyl groups
IXO608_RS22150	COG0438	transferase activity, transferring glycosyl groups
IXO608_RS22190	COG3040	lipid binding
IXO608_RS22270	COG4191	Histidine kinase
IXO608_RS22270	COG0784	Response regulator, receiver
IXO608_RS22290	COG0552	protein localization to endoplasmic reticulum
IXO608_RS22300	COG3938	Belongs to the proline racemase family
IXO608_RS22305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_RS22320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO608_RS22330	COG0006	proline dipeptidase activity
IXO608_RS22345	COG0531	amino acid
IXO608_RS22400	COG3328	transposase activity
IXO608_RS22465	COG0746	molybdenum cofactor guanylyltransferase activity
IXO608_RS22490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO608_RS22490	COG1648	precorrin-2 dehydrogenase activity
IXO608_RS22520	COG3039	Transposase
IXO608_RS22525	COG3039	Transposase
IXO608_RS22565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO608_RS22585	COG3039	Transposase
IXO608_RS22590	COG1054	Belongs to the UPF0176 family
IXO608_RS22605	COG1530	ribonuclease E activity
IXO608_RS22615	COG3064	Membrane
IXO608_RS22630	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO608_RS22635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO608_RS22635	COG0316	Belongs to the HesB IscA family
IXO608_RS22680	COG3039	Transposase
IXO608_RS22785	COG0631	protein serine/threonine phosphatase activity
IXO608_RS22790	COG0515	serine threonine protein kinase
IXO608_RS22825	COG1858	cytochrome C peroxidase
IXO608_RS22880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family