locus-tag	class	description
IXO639_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO639_RS00020	COG0187	DNA topoisomerase II activity
IXO639_RS00030	COG0501	Belongs to the peptidase M48B family
IXO639_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO639_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO639_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO639_RS00095	COG4772	TonB-dependent receptor
IXO639_RS00110	COG3039	Transposase
IXO639_RS00115	COG1304	FMN binding
IXO639_RS00135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO639_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_RS00230	COG2826	transposase and inactivated derivatives, IS30 family
IXO639_RS00255	COG3039	Transposase
IXO639_RS00265	COG1090	epimerase
IXO639_RS00285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO639_RS00395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO639_RS00470	COG3264	Mechanosensitive ion channel
IXO639_RS00470	COG1511	domain protein
IXO639_RS00485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO639_RS00490	COG2354	Protein conserved in bacteria
IXO639_RS00495	COG1649	PFAM Uncharacterised BCR, COG1649
IXO639_RS00515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO639_RS00540	COG0702	epimerase
IXO639_RS00555	COG1858	cytochrome C peroxidase
IXO639_RS00630	COG0513	Belongs to the DEAD box helicase family
IXO639_RS00635	COG3039	Transposase
IXO639_RS00680	COG1136	(ABC) transporter
IXO639_RS00720	COG1136	(ABC) transporter
IXO639_RS00760	COG1272	protein, Hemolysin III
IXO639_RS00765	COG1111	helicase
IXO639_RS00765	COG1205	dead DEAH box helicase
IXO639_RS00825	COG0067	glutamate synthase
IXO639_RS00825	COG0069	glutamate synthase activity
IXO639_RS00825	COG0070	glutamate synthase
IXO639_RS00830	COG0493	'glutamate synthase
IXO639_RS00880	COG1609	Transcriptional regulator
IXO639_RS00905	COG0366	Alpha amylase catalytic
IXO639_RS00910	COG0366	Alpha amylase catalytic
IXO639_RS00955	COG0606	chelatase, subunit chli
IXO639_RS00995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO639_RS01000	COG1166	arginine decarboxylase activity
IXO639_RS01060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO639_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS01110	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO639_RS01125	COG0210	DNA helicase
IXO639_RS01140	COG3132	Protein of unknown function, DUF480
IXO639_RS01145	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO639_RS01150	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO639_RS01185	COG2937	Belongs to the GPAT DAPAT family
IXO639_RS01225	COG3186	Phenylalanine-4-hydroxylase
IXO639_RS01230	COG1522	sequence-specific DNA binding
IXO639_RS01275	COG1064	alcohol dehydrogenase
IXO639_RS01280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_RS01290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_RS01300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_RS01320	COG0676	glucose-6-phosphate 1-epimerase activity
IXO639_RS01385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO639_RS01410	COG2853	Lipoprotein
IXO639_RS01425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO639_RS01430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO639_RS01435	COG1127	ABC transporter
IXO639_RS01510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_RS01520	COG3039	Transposase
IXO639_RS01525	COG3265	gluconokinase activity
IXO639_RS01530	COG2211	Major facilitator Superfamily
IXO639_RS01535	COG3459	Glycosyltransferase 36 associated
IXO639_RS01545	COG2205	protein histidine kinase activity
IXO639_RS01555	COG1414	Transcriptional regulator
IXO639_RS01560	COG0738	Major facilitator superfamily
IXO639_RS01565	COG3254	rhamnose metabolic process
IXO639_RS01595	COG0339	signal peptide processing
IXO639_RS01625	COG0564	pseudouridine synthase activity
IXO639_RS01635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO639_RS01645	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO639_RS01710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO639_RS01720	COG0842	Transport permease protein
IXO639_RS01725	COG1131	(ABC) transporter
IXO639_RS01755	COG1476	TRANSCRIPTIONal
IXO639_RS01765	COG4555	ABC transporter
IXO639_RS01800	COG0625	glutathione transferase activity
IXO639_RS01845	COG0583	DNA-binding transcription factor activity
IXO639_RS01885	COG1199	ATP-dependent helicase activity
IXO639_RS01920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO639_RS01950	COG3228	Belongs to the MtfA family
IXO639_RS01960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO639_RS01960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO639_RS01965	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO639_RS01980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO639_RS02015	COG3237	CsbD-like
IXO639_RS02020	COG0180	Tryptophanyl-tRNA synthetase
IXO639_RS02025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO639_RS02070	COG0753	catalase activity
IXO639_RS02085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO639_RS02095	COG0628	permease
IXO639_RS02110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO639_RS02115	COG1040	competence protein
IXO639_RS02120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO639_RS02125	COG0156	8-amino-7-oxononanoate synthase activity
IXO639_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS02150	COG0463	Glycosyl transferase, family 2
IXO639_RS02160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO639_RS02165	COG3100	YcgL domain-containing protein
IXO639_RS02180	COG3387	PFAM Glycoside hydrolase 15-related
IXO639_RS02185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO639_RS02200	COG2239	Acts as a magnesium transporter
IXO639_RS02215	COG1042	CoA-binding domain protein
IXO639_RS02215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO639_RS02215	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO639_RS02225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO639_RS02230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO639_RS02270	COG3485	protocatechuate 3,4-dioxygenase
IXO639_RS02290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO639_RS02295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO639_RS02320	COG4221	oxidoreductase activity
IXO639_RS02345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO639_RS02370	COG0463	Glycosyl transferase, family 2
IXO639_RS02385	COG1475	DNA binding
IXO639_RS02390	COG1192	Involved in chromosome partitioning
IXO639_RS02405	COG0708	Exodeoxyribonuclease III
IXO639_RS02410	COG2211	Major facilitator Superfamily
IXO639_RS02425	COG0739	heme binding
IXO639_RS02470	COG0745	RESPONSE REGULATOR receiver
IXO639_RS02505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO639_RS02520	COG2814	Major facilitator Superfamily
IXO639_RS02535	COG1289	transmembrane transporter activity
IXO639_RS02555	COG1136	(ABC) transporter
IXO639_RS02555	COG0577	efflux transmembrane transporter activity
IXO639_RS02560	COG0151	Belongs to the GarS family
IXO639_RS02570	COG0138	bifunctional purine biosynthesis protein purh
IXO639_RS02585	COG3039	Transposase
IXO639_RS02610	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO639_RS02650	COG0439	Biotin carboxylase
IXO639_RS02660	COG0511	ligase activity, forming carbon-carbon bonds
IXO639_RS02665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO639_RS02675	COG1324	tolerance protein
IXO639_RS02710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO639_RS02730	COG0534	Mate efflux family protein
IXO639_RS02735	COG0616	signal peptide processing
IXO639_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS02760	COG0009	L-threonylcarbamoyladenylate synthase
IXO639_RS02765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO639_RS02765	COG1754	DNA topoisomerase type I activity
IXO639_RS02780	COG2922	Belongs to the Smg family
IXO639_RS02785	COG0758	DNA mediated transformation
IXO639_RS02790	COG1652	LysM domain
IXO639_RS02795	COG0242	peptide deformylase activity
IXO639_RS02800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO639_RS02805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO639_RS02805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO639_RS02855	COG1560	Kdo2-lipid A biosynthetic process
IXO639_RS02865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO639_RS03010	COG3039	Transposase
IXO639_RS03020	COG1271	oxidase subunit
IXO639_RS03085	COG0531	amino acid
IXO639_RS03105	COG3590	peptidase
IXO639_RS03115	COG0667	Aldo Keto reductase
IXO639_RS03130	COG3384	dioxygenase
IXO639_RS03140	COG1573	uracil-dna glycosylase
IXO639_RS03150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO639_RS03160	COG0025	NhaP-type Na H and K H
IXO639_RS03165	COG1131	(ABC) transporter
IXO639_RS03170	COG0842	Transport permease protein
IXO639_RS03185	COG1404	Belongs to the peptidase S8 family
IXO639_RS03200	COG0745	RESPONSE REGULATOR receiver
IXO639_RS03250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_RS03275	COG2205	protein histidine kinase activity
IXO639_RS03275	COG2202	Pas domain
IXO639_RS03305	COG2813	Specifically methylates the guanine in position
IXO639_RS03310	COG1187	pseudouridine synthase activity
IXO639_RS03315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO639_RS03350	COG0697	spore germination
IXO639_RS03360	COG2011	ABC-type metal ion transport system permease component
IXO639_RS03390	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO639_RS03400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO639_RS03420	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO639_RS03430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO639_RS03440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO639_RS03445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO639_RS03450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO639_RS03455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO639_RS03505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_RS03510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO639_RS03560	COG0339	signal peptide processing
IXO639_RS03595	COG1956	GAF domain-containing protein
IXO639_RS03600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO639_RS03610	COG0720	synthase
IXO639_RS03615	COG0513	Belongs to the DEAD box helicase family
IXO639_RS03625	COG0625	glutathione transferase activity
IXO639_RS03655	COG0626	cystathionine gamma-synthase activity
IXO639_RS03695	COG3328	transposase activity
IXO639_RS03720	COG2086	electron transfer activity
IXO639_RS03745	COG0662	Cupin 2, conserved barrel domain protein
IXO639_RS03745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO639_RS03750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO639_RS03785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO639_RS03785	COG3218	ABC-type transport auxiliary lipoprotein component
IXO639_RS03790	COG1127	ABC transporter
IXO639_RS03795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO639_RS03815	COG0442	prolyl-tRNA aminoacylation
IXO639_RS03825	COG1183	phosphatidylcholine synthase activity
IXO639_RS03855	COG3039	Transposase
IXO639_RS03890	COG3039	Transposase
IXO639_RS03920	COG0525	valine-tRNA ligase activity
IXO639_RS03935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO639_RS03945	COG0795	lipopolysaccharide-transporting ATPase activity
IXO639_RS03960	COG4974	Belongs to the 'phage' integrase family
IXO639_RS03965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO639_RS03970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO639_RS03970	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO639_RS03975	COG5295	Hep Hag repeat protein
IXO639_RS03985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO639_RS03995	COG1459	type II secretion system
IXO639_RS04000	COG2165	general secretion pathway protein
IXO639_RS04005	COG4970	Tfp pilus assembly protein FimT
IXO639_RS04010	COG2165	general secretion pathway protein
IXO639_RS04015	COG4795	General secretion pathway protein
IXO639_RS04020	COG3156	type II secretion system protein K
IXO639_RS04025	COG3166	PFAM Fimbrial assembly family protein
IXO639_RS04040	COG1450	Type ii and iii secretion system protein
IXO639_RS04055	COG2188	Transcriptional regulator
IXO639_RS04100	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO639_RS04105	COG1518	maintenance of DNA repeat elements
IXO639_RS04140	COG3039	Transposase
IXO639_RS04155	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO639_RS04180	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS04185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO639_RS04195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO639_RS04200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO639_RS04235	COG3829	transcription factor binding
IXO639_RS04315	COG2826	transposase and inactivated derivatives, IS30 family
IXO639_RS04325	COG0678	peroxiredoxin activity
IXO639_RS04345	COG0330	HflC and HflK could
IXO639_RS04350	COG0330	HflC and HflK could
IXO639_RS04360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO639_RS04365	COG0308	aminopeptidase N
IXO639_RS04425	COG1560	Kdo2-lipid A biosynthetic process
IXO639_RS04430	COG1519	Transferase
IXO639_RS04435	COG1538	Outer membrane efflux protein
IXO639_RS04440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO639_RS04470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO639_RS04475	COG0066	3-isopropylmalate dehydratase activity
IXO639_RS04480	COG2226	methyltransferase
IXO639_RS04510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO639_RS04520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO639_RS04525	COG3710	Transcriptional regulator
IXO639_RS04550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO639_RS04570	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO639_RS04605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO639_RS04615	COG3781	membrane
IXO639_RS04750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO639_RS04770	COG1217	gtp-binding protein TYPA
IXO639_RS04775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO639_RS04780	COG0039	L-malate dehydrogenase activity
IXO639_RS04785	COG0625	glutathione transferase activity
IXO639_RS04800	COG3039	Transposase
IXO639_RS04825	COG0584	glycerophosphoryl diester phosphodiesterase
IXO639_RS04860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO639_RS04895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO639_RS04900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO639_RS04905	COG0583	DNA-binding transcription factor activity
IXO639_RS04910	COG3634	alkyl hydroperoxide reductase activity
IXO639_RS04920	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO639_RS04965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO639_RS04965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO639_RS04980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO639_RS05005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO639_RS05030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO639_RS05040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO639_RS05070	COG1295	ribonuclease BN
IXO639_RS05075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO639_RS05095	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO639_RS05105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO639_RS05110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO639_RS05120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO639_RS05135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO639_RS05145	COG0193	aminoacyl-tRNA hydrolase activity
IXO639_RS05150	COG0012	GTP binding
IXO639_RS05180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO639_RS05185	COG0250	Participates in transcription elongation, termination and antitermination
IXO639_RS05190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO639_RS05200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO639_RS05205	COG0222	ribosome binding
IXO639_RS05210	COG0085	RNA polymerase activity
IXO639_RS05215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO639_RS05220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO639_RS05225	COG0049	tRNA binding
IXO639_RS05245	COG0051	transcription antitermination factor activity, RNA binding
IXO639_RS05250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO639_RS05255	COG0088	Forms part of the polypeptide exit tunnel
IXO639_RS05260	COG0089	rRNA binding
IXO639_RS05275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO639_RS05285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO639_RS05290	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO639_RS05295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO639_RS05300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO639_RS05310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO639_RS05340	COG1841	ribosomal large subunit assembly
IXO639_RS05350	COG0201	protein transport
IXO639_RS05360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO639_RS05365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO639_RS05375	COG0203	ribosomal protein L17
IXO639_RS05435	COG3551	Protein conserved in bacteria
IXO639_RS05465	COG2194	sulfuric ester hydrolase activity
IXO639_RS05475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO639_RS05480	COG0745	RESPONSE REGULATOR receiver
IXO639_RS05485	COG0642	Histidine kinase
IXO639_RS05495	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO639_RS05500	COG2894	cell division
IXO639_RS05515	COG4585	Histidine kinase
IXO639_RS05520	COG2197	response regulator
IXO639_RS05535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO639_RS05560	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO639_RS05675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_RS05690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_RS05700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_RS05745	COG3328	transposase activity
IXO639_RS05760	COG3179	chitinase
IXO639_RS05875	COG3039	Transposase
IXO639_RS05890	COG3039	Transposase
IXO639_RS05950	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO639_RS05970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO639_RS05975	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO639_RS05980	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO639_RS05995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO639_RS06070	COG0587	DNA-directed DNA polymerase activity
IXO639_RS06085	COG1297	OPT oligopeptide transporter protein
IXO639_RS06105	COG0823	Involved in the tonB-independent uptake of proteins
IXO639_RS06105	COG1506	peptidase
IXO639_RS06125	COG1917	Cupin 2, conserved barrel domain protein
IXO639_RS06125	COG2207	Transcriptional regulator
IXO639_RS06150	COG0753	catalase activity
IXO639_RS06180	COG0126	phosphoglycerate kinase activity
IXO639_RS06190	COG0469	pyruvate kinase activity
IXO639_RS06195	COG3588	fructose-bisphosphate aldolase
IXO639_RS06200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO639_RS06245	COG2198	Histidine kinase
IXO639_RS06245	COG2205	protein histidine kinase activity
IXO639_RS06245	COG0784	Response regulator, receiver
IXO639_RS06265	COG0175	sulfate reduction
IXO639_RS06270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO639_RS06275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO639_RS06280	COG0175	sulfate reduction
IXO639_RS06285	COG2895	sulfate adenylyltransferase (ATP) activity
IXO639_RS06285	COG0529	Catalyzes the synthesis of activated sulfate
IXO639_RS06295	COG3039	Transposase
IXO639_RS06305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO639_RS06310	COG0308	aminopeptidase N
IXO639_RS06330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO639_RS06350	COG1970	mechanosensitive ion channel activity
IXO639_RS06380	COG0471	metal ion transport
IXO639_RS06380	COG3273	potassium ion transport
IXO639_RS06390	COG2022	thiamine diphosphate biosynthetic process
IXO639_RS06450	COG3039	Transposase
IXO639_RS06515	COG3118	belongs to the thioredoxin family
IXO639_RS06540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO639_RS06560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO639_RS06590	COG2968	Membrane
IXO639_RS06605	COG3164	Protein of unknown function
IXO639_RS06615	COG0312	modulator of DNA gyrase
IXO639_RS06620	COG3028	Belongs to the UPF0307 family
IXO639_RS06625	COG0312	modulator of DNA gyrase
IXO639_RS06650	COG0142	geranyltranstransferase activity
IXO639_RS06655	COG1722	exodeoxyribonuclease VII activity
IXO639_RS06660	COG0037	tRNA processing
IXO639_RS06665	COG1785	Belongs to the alkaline phosphatase family
IXO639_RS06685	COG0791	NLP P60 protein
IXO639_RS06690	COG0791	NLP P60 protein
IXO639_RS06695	COG1047	Peptidyl-prolyl cis-trans
IXO639_RS06700	COG2311	Membrane
IXO639_RS06705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_RS06745	COG0489	protein tyrosine kinase activity
IXO639_RS06750	COG0717	Belongs to the dCTP deaminase family
IXO639_RS06780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO639_RS06820	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO639_RS06825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO639_RS06830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO639_RS06835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO639_RS06855	COG0101	tRNA pseudouridine synthase activity
IXO639_RS06860	COG0135	phosphoribosylanthranilate isomerase activity
IXO639_RS06880	COG0159	tryptophan synthase activity
IXO639_RS06885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO639_RS06890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO639_RS06940	COG0149	triose-phosphate isomerase activity
IXO639_RS06955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO639_RS06965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO639_RS06970	COG0649	NAD binding
IXO639_RS06975	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO639_RS06980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO639_RS06985	COG1034	ATP synthesis coupled electron transport
IXO639_RS06990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO639_RS07020	COG1007	ATP synthesis coupled electron transport
IXO639_RS07030	COG0779	Required for maturation of 30S ribosomal subunits
IXO639_RS07035	COG0195	Participates in both transcription termination and antitermination
IXO639_RS07040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO639_RS07055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO639_RS07060	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO639_RS07095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO639_RS07105	COG2095	MarC family integral membrane protein
IXO639_RS07120	COG1611	Belongs to the LOG family
IXO639_RS07160	COG4969	Belongs to the N-Me-Phe pilin family
IXO639_RS07165	COG0556	nucleotide-excision repair
IXO639_RS07205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO639_RS07220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO639_RS07275	COG0438	transferase activity, transferring glycosyl groups
IXO639_RS07280	COG0438	transferase activity, transferring glycosyl groups
IXO639_RS07290	COG0438	transferase activity, transferring glycosyl groups
IXO639_RS07330	COG3040	lipid binding
IXO639_RS07410	COG3039	Transposase
IXO639_RS07415	COG4191	Histidine kinase
IXO639_RS07415	COG0784	Response regulator, receiver
IXO639_RS07435	COG0552	protein localization to endoplasmic reticulum
IXO639_RS07445	COG3938	Belongs to the proline racemase family
IXO639_RS07450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_RS07465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO639_RS07475	COG0006	proline dipeptidase activity
IXO639_RS07490	COG0531	amino acid
IXO639_RS07520	COG4206	TonB-dependent receptor
IXO639_RS07545	COG3328	transposase activity
IXO639_RS07605	COG0746	molybdenum cofactor guanylyltransferase activity
IXO639_RS07630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO639_RS07630	COG1648	precorrin-2 dehydrogenase activity
IXO639_RS07660	COG3039	Transposase
IXO639_RS07665	COG3039	Transposase
IXO639_RS07700	COG3039	Transposase
IXO639_RS07715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO639_RS07735	COG1054	Belongs to the UPF0176 family
IXO639_RS07750	COG1530	ribonuclease E activity
IXO639_RS07760	COG3064	Membrane
IXO639_RS07775	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO639_RS07825	COG3039	Transposase
IXO639_RS07940	COG0631	protein serine/threonine phosphatase activity
IXO639_RS07945	COG0515	serine threonine protein kinase
IXO639_RS07975	COG1858	cytochrome C peroxidase
IXO639_RS08030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_RS08055	COG2201	protein-glutamate methylesterase activity
IXO639_RS08100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO639_RS08120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO639_RS08135	COG1595	DNA-templated transcription, initiation
IXO639_RS08185	COG2244	polysaccharide biosynthetic process
IXO639_RS08215	COG2264	protein methyltransferase activity
IXO639_RS08225	COG0438	transferase activity, transferring glycosyl groups
IXO639_RS08240	COG1136	(ABC) transporter
IXO639_RS08245	COG1132	(ABC) transporter
IXO639_RS08255	COG0477	Major facilitator Superfamily
IXO639_RS08265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO639_RS08280	COG1253	flavin adenine dinucleotide binding
IXO639_RS08290	COG0306	phosphate transporter
IXO639_RS08320	COG0504	CTP synthase activity
IXO639_RS08325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO639_RS08335	COG0148	phosphopyruvate hydratase activity
IXO639_RS08340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO639_RS08345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO639_RS08355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO639_RS08365	COG2840	Smr protein MutS2
IXO639_RS08370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO639_RS08375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO639_RS08380	COG1238	metal cluster binding
IXO639_RS08395	COG1534	Rna-binding protein
IXO639_RS08400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO639_RS08410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO639_RS08425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO639_RS08430	COG1546	Belongs to the CinA family
IXO639_RS08445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO639_RS08450	COG2137	regulation of response to DNA damage stimulus
IXO639_RS08455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO639_RS08460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO639_RS08485	COG0305	Participates in initiation and elongation during chromosome replication
IXO639_RS08490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO639_RS08515	COG1741	Belongs to the pirin family
IXO639_RS08520	COG0583	DNA-binding transcription factor activity
IXO639_RS08545	COG0351	phosphomethylpyrimidine kinase
IXO639_RS08555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO639_RS08560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO639_RS08580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO639_RS08590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO639_RS08595	COG3734	2-keto-3-deoxy-galactonokinase
IXO639_RS08605	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_RS08610	COG0800	Aldolase
IXO639_RS08625	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO639_RS08635	COG1070	Carbohydrate kinase
IXO639_RS08645	COG0477	Major facilitator Superfamily
IXO639_RS08665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO639_RS08710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO639_RS08715	COG2258	MOSC domain
IXO639_RS08725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO639_RS08730	COG0505	Belongs to the CarA family
IXO639_RS08740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO639_RS08745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO639_RS08755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO639_RS08815	COG0784	Response regulator, receiver
IXO639_RS08815	COG2198	Histidine kinase
IXO639_RS08815	COG2205	protein histidine kinase activity
IXO639_RS08820	COG1024	Enoyl-CoA hydratase
IXO639_RS08825	COG0318	PFAM AMP-dependent synthetase and ligase
IXO639_RS08855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO639_RS08885	COG0840	transmembrane signaling receptor activity
IXO639_RS08905	COG3039	Transposase
IXO639_RS08920	COG0835	chemotaxis
IXO639_RS08935	COG0840	transmembrane signaling receptor activity
IXO639_RS08940	COG0840	transmembrane signaling receptor activity
IXO639_RS08945	COG0840	transmembrane signaling receptor activity
IXO639_RS08950	COG0840	transmembrane signaling receptor activity
IXO639_RS08960	COG0840	transmembrane signaling receptor activity
IXO639_RS08970	COG0840	transmembrane signaling receptor activity
IXO639_RS09000	COG0745	RESPONSE REGULATOR receiver
IXO639_RS09010	COG0835	chemotaxis
IXO639_RS09025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO639_RS09045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO639_RS09055	COG4771	TonB-dependent receptor
IXO639_RS09090	COG3039	Transposase
IXO639_RS09165	COG3409	Peptidoglycan-binding domain 1 protein
IXO639_RS09165	COG3501	Rhs element vgr protein
IXO639_RS09185	COG3409	Peptidoglycan-binding domain 1 protein
IXO639_RS09185	COG3501	Rhs element vgr protein
IXO639_RS09230	COG3039	Transposase
IXO639_RS09245	COG3039	Transposase
IXO639_RS09255	COG3039	Transposase
IXO639_RS09270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO639_RS09270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO639_RS09275	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO639_RS09280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO639_RS09280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO639_RS09285	COG1609	Transcriptional regulator
IXO639_RS09310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO639_RS09315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_RS09325	COG2902	Dehydrogenase
IXO639_RS09330	COG3039	Transposase
IXO639_RS09340	COG5002	protein histidine kinase activity
IXO639_RS09340	COG2205	protein histidine kinase activity
IXO639_RS09340	COG0784	Response regulator, receiver
IXO639_RS09345	COG2733	membrane
IXO639_RS09355	COG1121	(ABC) transporter
IXO639_RS09360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO639_RS09370	COG2223	nitrite transmembrane transporter activity
IXO639_RS09380	COG0243	molybdopterin cofactor binding
IXO639_RS09390	COG0477	Major facilitator Superfamily
IXO639_RS09400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_RS09405	COG0174	glutamine synthetase
IXO639_RS09410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO639_RS09440	COG3842	ATPase activity
IXO639_RS09460	COG1012	belongs to the aldehyde dehydrogenase family
IXO639_RS09475	COG4535	Mg2 and Co2 transporter CorC
IXO639_RS09495	COG1702	phosphate starvation-inducible protein PhoH
IXO639_RS09520	COG0741	lytic transglycosylase activity
IXO639_RS09525	COG0723	plastoquinol--plastocyanin reductase activity
IXO639_RS09530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO639_RS09535	COG2857	Cytochrome c1
IXO639_RS09540	COG0625	glutathione transferase activity
IXO639_RS09545	COG2969	positive regulation of protein catabolic process
IXO639_RS09570	COG2094	Belongs to the DNA glycosylase MPG family
IXO639_RS09580	COG3328	transposase activity
IXO639_RS09650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_RS09670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO639_RS09675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO639_RS09675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO639_RS09680	COG0802	atpase or kinase
IXO639_RS09685	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO639_RS09690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO639_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS09720	COG0501	Belongs to the peptidase M48B family
IXO639_RS09730	COG2081	HI0933 family
IXO639_RS09735	COG4681	YaeQ
IXO639_RS09740	COG1671	Belongs to the UPF0178 family
IXO639_RS09750	COG0625	glutathione transferase activity
IXO639_RS09760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO639_RS09765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO639_RS09770	COG0513	Belongs to the DEAD box helicase family
IXO639_RS09775	COG0488	(ABC) transporter
IXO639_RS09795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO639_RS09800	COG0483	inositol monophosphate 1-phosphatase activity
IXO639_RS09815	COG3300	MHYT domain
IXO639_RS09815	COG5001	Diguanylate cyclase
IXO639_RS09820	COG1509	lysine 2,3-aminomutase activity
IXO639_RS09835	COG0402	S-adenosylhomocysteine deaminase activity
IXO639_RS09840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO639_RS09865	COG4677	pectinesterase activity
IXO639_RS09890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO639_RS09920	COG2166	iron-sulfur cluster assembly
IXO639_RS09935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO639_RS09940	COG0137	argininosuccinate synthase activity
IXO639_RS09950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO639_RS09955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO639_RS09970	COG0165	Argininosuccinate lyase
IXO639_RS09990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO639_RS10025	COG3039	Transposase
IXO639_RS10040	COG4988	ABC transporter
IXO639_RS10045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO639_RS10055	COG3039	Transposase
IXO639_RS10145	COG3039	Transposase
IXO639_RS10160	COG3209	COG3209 Rhs family protein
IXO639_RS10170	COG3039	Transposase
IXO639_RS10205	COG0784	Response regulator, receiver
IXO639_RS10205	COG2198	Histidine kinase
IXO639_RS10205	COG0643	Histidine kinase
IXO639_RS10260	COG1684	flagellar biosynthetic protein fliR
IXO639_RS10275	COG3190	flagellar
IXO639_RS10325	COG1677	Flagellar hook-basal body complex protein FliE
IXO639_RS10355	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS10365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO639_RS10385	COG2201	protein-glutamate methylesterase activity
IXO639_RS10420	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO639_RS10425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO639_RS10460	COG4787	bacterial-type flagellum-dependent cell motility
IXO639_RS10470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO639_RS10475	COG1558	bacterial-type flagellum-dependent cell motility
IXO639_RS10485	COG0835	chemotaxis
IXO639_RS10485	COG0784	Response regulator, receiver
IXO639_RS10505	COG5002	protein histidine kinase activity
IXO639_RS10515	COG4585	Histidine kinase
IXO639_RS10520	COG5001	Diguanylate cyclase
IXO639_RS10545	COG0482	sulfurtransferase activity
IXO639_RS10560	COG0542	response to heat
IXO639_RS10595	COG0492	ferredoxin-NADP+ reductase activity
IXO639_RS10600	COG1674	ftsk spoiiie
IXO639_RS10620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO639_RS10640	COG0038	chloride channel
IXO639_RS10645	COG0183	Belongs to the thiolase family
IXO639_RS10650	COG1024	Enoyl-CoA hydratase
IXO639_RS10650	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO639_RS10665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO639_RS10675	COG1426	Protein conserved in bacteria
IXO639_RS10685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_RS10695	COG0303	'Molybdopterin
IXO639_RS10750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO639_RS10800	COG0742	ribosomal rna small subunit methyltransferase
IXO639_RS10805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO639_RS10820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO639_RS10825	COG0405	Gamma-glutamyltransferase
IXO639_RS10850	COG3039	Transposase
IXO639_RS10925	COG0343	queuine tRNA-ribosyltransferase activity
IXO639_RS10930	COG1862	Preprotein translocase
IXO639_RS10935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO639_RS10940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO639_RS10950	COG3039	Transposase
IXO639_RS10980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO639_RS10990	COG0704	Plays a role in the regulation of phosphate uptake
IXO639_RS11005	COG0573	inorganic phosphate transmembrane transporter activity
IXO639_RS11010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO639_RS11060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO639_RS11070	COG1024	Enoyl-CoA hydratase
IXO639_RS11085	COG0494	nUDIX hydrolase
IXO639_RS11130	COG0116	Belongs to the methyltransferase superfamily
IXO639_RS11130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO639_RS11155	COG0667	Aldo Keto reductase
IXO639_RS11165	COG2925	Exonuclease
IXO639_RS11190	COG0288	reversible hydration of carbon dioxide
IXO639_RS11220	COG0316	Belongs to the HesB IscA family
IXO639_RS11225	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO639_RS11235	COG0359	binds to the 23S rRNA
IXO639_RS11245	COG3115	cell septum assembly
IXO639_RS11265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO639_RS11285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO639_RS11310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO639_RS11320	COG2986	histidine ammonia-lyase
IXO639_RS11325	COG1228	amidohydrolase
IXO639_RS11365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO639_RS11375	COG0077	Prephenate dehydratase
IXO639_RS11375	COG1605	Chorismate mutase
IXO639_RS11380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO639_RS11415	COG4566	intracellular signal transduction
IXO639_RS11460	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO639_RS11465	COG1469	GTP cyclohydrolase I activity
IXO639_RS11475	COG0617	tRNA 3'-terminal CCA addition
IXO639_RS11485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO639_RS11490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO639_RS11520	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO639_RS11535	COG2203	Gaf domain
IXO639_RS11535	COG3706	GGDEF domain
IXO639_RS11535	COG4251	negative regulation of phosphorylation
IXO639_RS11535	COG5001	Diguanylate cyclase
IXO639_RS11595	COG1595	DNA-templated transcription, initiation
IXO639_RS11620	COG0386	Belongs to the glutathione peroxidase family
IXO639_RS11695	COG3039	Transposase
IXO639_RS11710	COG5002	protein histidine kinase activity
IXO639_RS11710	COG0784	Response regulator, receiver
IXO639_RS11710	COG2205	protein histidine kinase activity
IXO639_RS11750	COG0800	Aldolase
IXO639_RS11755	COG0129	dihydroxy-acid dehydratase activity
IXO639_RS11760	COG0363	glucosamine-6-phosphate deaminase activity
IXO639_RS11770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO639_RS11785	COG0354	folic acid binding
IXO639_RS11800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO639_RS11815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO639_RS11830	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO639_RS11855	COG0811	peptide transport
IXO639_RS11870	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO639_RS11880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO639_RS11890	COG0322	excinuclease ABC activity
IXO639_RS11925	COG3328	transposase activity
IXO639_RS11945	COG3039	Transposase
IXO639_RS11965	COG2201	protein-glutamate methylesterase activity
IXO639_RS12100	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO639_RS12100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO639_RS12110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO639_RS12120	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO639_RS12120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO639_RS12135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO639_RS12155	COG0124	histidyl-tRNA synthetase
IXO639_RS12170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO639_RS12205	COG1012	belongs to the aldehyde dehydrogenase family
IXO639_RS12235	COG0697	spore germination
IXO639_RS12260	COG0671	phosphoesterase, PA-phosphatase related
IXO639_RS12275	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO639_RS12290	COG2183	response to ionizing radiation
IXO639_RS12300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_RS12300	COG0723	plastoquinol--plastocyanin reductase activity
IXO639_RS12315	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO639_RS12325	COG1183	phosphatidylcholine synthase activity
IXO639_RS12330	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS12355	COG0668	transmembrane transport
IXO639_RS12375	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO639_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS12425	COG0583	DNA-binding transcription factor activity
IXO639_RS12430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO639_RS12435	COG3002	Belongs to the UPF0753 family
IXO639_RS12450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO639_RS12470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO639_RS12480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO639_RS12485	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO639_RS12495	COG0776	regulation of translation
IXO639_RS12500	COG0539	negative regulation of cytoplasmic translation
IXO639_RS12505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO639_RS12520	COG2957	Belongs to the agmatine deiminase family
IXO639_RS12530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO639_RS12555	COG0395	ABC-type sugar transport system, permease component
IXO639_RS12560	COG1175	transmembrane transport
IXO639_RS12590	COG2350	Protein conserved in bacteria
IXO639_RS12595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO639_RS12600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO639_RS12605	COG1187	pseudouridine synthase activity
IXO639_RS12630	COG0436	Aminotransferase
IXO639_RS12695	COG0277	FAD linked oxidase domain protein
IXO639_RS12700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO639_RS12710	COG0531	amino acid
IXO639_RS12715	COG0531	amino acid
IXO639_RS12720	COG0235	Class ii aldolase
IXO639_RS12725	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO639_RS12755	COG2201	protein-glutamate methylesterase activity
IXO639_RS12805	COG0583	DNA-binding transcription factor activity
IXO639_RS12815	COG3039	Transposase
IXO639_RS12920	COG3039	Transposase
IXO639_RS12930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO639_RS12950	COG0557	exoribonuclease II activity
IXO639_RS12975	COG1960	acyl-CoA dehydrogenase activity
IXO639_RS12980	COG2226	methyltransferase
IXO639_RS12985	COG1410	methionine synthase
IXO639_RS12985	COG0646	methionine synthase
IXO639_RS12990	COG0646	methionine synthase
IXO639_RS12990	COG1410	methionine synthase
IXO639_RS13000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_RS13010	COG1609	Transcriptional regulator
IXO639_RS13025	COG2900	Belongs to the SlyX family
IXO639_RS13040	COG0386	Belongs to the glutathione peroxidase family
IXO639_RS13050	COG1725	Transcriptional regulator
IXO639_RS13055	COG1131	(ABC) transporter
IXO639_RS13120	COG2850	peptidyl-arginine hydroxylation
IXO639_RS13155	COG1132	(ABC) transporter
IXO639_RS13180	COG0287	Prephenate dehydrogenase
IXO639_RS13180	COG1605	Chorismate mutase
IXO639_RS13185	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO639_RS13190	COG0484	heat shock protein binding
IXO639_RS13195	COG0443	Heat shock 70 kDa protein
IXO639_RS13200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO639_RS13210	COG0497	DNA recombination
IXO639_RS13220	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_RS13225	COG2914	Belongs to the UPF0125 (RnfH) family
IXO639_RS13235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO639_RS13250	COG1960	acyl-CoA dehydrogenase activity
IXO639_RS13260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO639_RS13315	COG2814	Major facilitator Superfamily
IXO639_RS13320	COG1566	PFAM secretion protein HlyD family protein
IXO639_RS13335	COG2207	Transcriptional regulator
IXO639_RS13360	COG4774	siderophore transport
IXO639_RS13370	COG0367	asparagine synthase
IXO639_RS13385	COG1393	Belongs to the ArsC family
IXO639_RS13400	COG3039	Transposase
IXO639_RS13450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO639_RS13465	COG0233	cytoplasmic translational termination
IXO639_RS13475	COG0575	Belongs to the CDS family
IXO639_RS13485	COG0750	zinc metalloprotease
IXO639_RS13505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO639_RS13510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO639_RS13530	COG0825	malonyl-CoA metabolic process
IXO639_RS13540	COG4771	TonB-dependent receptor
IXO639_RS13545	COG1131	(ABC) transporter
IXO639_RS13570	COG1981	membrane
IXO639_RS13615	COG0529	Catalyzes the synthesis of activated sulfate
IXO639_RS13615	COG2895	sulfate adenylyltransferase (ATP) activity
IXO639_RS13650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO639_RS13665	COG2040	homocysteine
IXO639_RS13670	COG0833	amino acid
IXO639_RS13690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO639_RS13690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO639_RS13700	COG2878	Part of a membrane complex involved in electron transport
IXO639_RS13715	COG1595	DNA-templated transcription, initiation
IXO639_RS13740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO639_RS13755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO639_RS13760	COG0251	oxidation-reduction process
IXO639_RS13770	COG0392	lysyltransferase activity
IXO639_RS13770	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO639_RS13800	COG3039	Transposase
IXO639_RS13815	COG2814	Major facilitator Superfamily
IXO639_RS13820	COG1902	pentaerythritol trinitrate reductase activity
IXO639_RS13830	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO639_RS13845	COG1047	Peptidyl-prolyl cis-trans
IXO639_RS13885	COG3039	Transposase
IXO639_RS13895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO639_RS13910	COG1451	nucleotide metabolic process
IXO639_RS13930	COG0183	Belongs to the thiolase family
IXO639_RS13960	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO639_RS13960	COG1793	dna ligase
IXO639_RS13970	COG1793	dna ligase
IXO639_RS13975	COG1201	RNA secondary structure unwinding
IXO639_RS13995	COG1278	Cold shock
IXO639_RS14000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO639_RS14005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO639_RS14015	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO639_RS14025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO639_RS14050	COG3039	Transposase
IXO639_RS14060	COG2954	triphosphatase activity
IXO639_RS14075	COG1381	Involved in DNA repair and RecF pathway recombination
IXO639_RS14105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO639_RS14120	COG1024	Enoyl-CoA hydratase
IXO639_RS14120	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO639_RS14140	COG1024	Enoyl-CoA hydratase
IXO639_RS14145	COG1960	acyl-CoA dehydrogenase activity
IXO639_RS14215	COG2353	YceI-like domain
IXO639_RS14225	COG2353	YceI-like domain
IXO639_RS14240	COG1760	l-serine dehydratase
IXO639_RS14250	COG0626	cystathionine gamma-synthase activity
IXO639_RS14255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO639_RS14260	COG0739	heme binding
IXO639_RS14270	COG1272	protein, Hemolysin III
IXO639_RS14295	COG0463	Glycosyl transferase, family 2
IXO639_RS14305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO639_RS14315	COG4771	TonB-dependent receptor
IXO639_RS14320	COG1309	transcriptional regulator
IXO639_RS14330	COG1960	acyl-CoA dehydrogenase activity
IXO639_RS14360	COG0509	glycine decarboxylation via glycine cleavage system
IXO639_RS14375	COG0330	HflC and HflK could
IXO639_RS14390	COG3956	TIGRFAM MazG family protein
IXO639_RS14400	COG0494	nUDIX hydrolase
IXO639_RS14410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO639_RS14415	COG0837	glucose binding
IXO639_RS14430	COG1388	LysM domain
IXO639_RS14430	COG3858	chitin binding
IXO639_RS14440	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO639_RS14450	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO639_RS14510	COG3537	Alpha-1,2-mannosidase
IXO639_RS14550	COG3142	Participates in the control of copper homeostasis
IXO639_RS14555	COG1446	asparaginase
IXO639_RS14565	COG2304	oxidoreductase activity
IXO639_RS14570	COG2304	oxidoreductase activity
IXO639_RS14610	COG0643	Histidine kinase
IXO639_RS14610	COG0784	Response regulator, receiver
IXO639_RS14610	COG2198	Histidine kinase
IXO639_RS14615	COG0840	transmembrane signaling receptor activity
IXO639_RS14620	COG0835	chemotaxis
IXO639_RS14635	COG0189	ligase activity
IXO639_RS14645	COG1397	ADP-ribosylglycohydrolase
IXO639_RS14655	COG1199	ATP-dependent helicase activity
IXO639_RS14665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO639_RS14670	COG1215	transferase activity, transferring glycosyl groups
IXO639_RS14680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO639_RS14700	COG0535	radical SAM domain protein
IXO639_RS14705	COG0535	radical SAM domain protein
IXO639_RS14740	COG1643	Atp-dependent helicase
IXO639_RS14745	COG0783	Belongs to the Dps family
IXO639_RS14750	COG0514	ATP-dependent DNA helicase (RecQ)
IXO639_RS14775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO639_RS14830	COG1187	pseudouridine synthase activity
IXO639_RS14835	COG0602	queuosine metabolic process
IXO639_RS14845	COG2885	chlorophyll binding
IXO639_RS14860	COG0848	biopolymer transport protein
IXO639_RS14870	COG0824	Thioesterase
IXO639_RS14875	COG2255	four-way junction helicase activity
IXO639_RS14885	COG0632	four-way junction helicase activity
IXO639_RS15015	COG3209	COG3209 Rhs family protein
IXO639_RS15035	COG3209	COG3209 Rhs family protein
IXO639_RS15035	COG3209	COG3209 Rhs family protein
IXO639_RS15060	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO639_RS15065	COG1845	cytochrome c oxidase, subunit III
IXO639_RS15070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO639_RS15085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO639_RS15090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO639_RS15100	COG0196	riboflavin kinase activity
IXO639_RS15105	COG0728	peptidoglycan biosynthetic process
IXO639_RS15110	COG0268	Binds directly to 16S ribosomal RNA
IXO639_RS15115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO639_RS15120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO639_RS15130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO639_RS15135	COG0824	Thioesterase
IXO639_RS15150	COG1946	Acyl-CoA thioesterase
IXO639_RS15175	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO639_RS15210	COG1877	trehalose-phosphatase activity
IXO639_RS15215	COG3387	PFAM Glycoside hydrolase 15-related
IXO639_RS15240	COG0564	pseudouridine synthase activity
IXO639_RS15245	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_RS15250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO639_RS15250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO639_RS15260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO639_RS15265	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO639_RS15290	COG2184	nucleotidyltransferase activity
IXO639_RS15310	COG2194	sulfuric ester hydrolase activity
IXO639_RS15315	COG4969	Belongs to the N-Me-Phe pilin family
IXO639_RS15325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO639_RS15345	COG3039	Transposase
IXO639_RS15365	COG3039	Transposase
IXO639_RS15400	COG1132	(ABC) transporter
IXO639_RS15430	COG0745	RESPONSE REGULATOR receiver
IXO639_RS15435	COG5002	protein histidine kinase activity
IXO639_RS15435	COG5000	phosphorelay sensor kinase activity
IXO639_RS15440	COG0475	glutathione-regulated potassium exporter activity
IXO639_RS15450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO639_RS15470	COG1187	pseudouridine synthase activity
IXO639_RS15475	COG5001	Diguanylate cyclase
IXO639_RS15475	COG5002	protein histidine kinase activity
IXO639_RS15595	COG0415	Belongs to the DNA photolyase family
IXO639_RS15600	COG0305	Participates in initiation and elongation during chromosome replication
IXO639_RS15610	COG0367	asparagine synthase
IXO639_RS15635	COG1960	acyl-CoA dehydrogenase activity
IXO639_RS15650	COG0084	hydrolase, TatD family'
IXO639_RS15655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO639_RS15715	COG0735	belongs to the Fur family
IXO639_RS15720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO639_RS15735	COG3039	Transposase
IXO639_RS15820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO639_RS15830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO639_RS15845	COG2198	Histidine kinase
IXO639_RS15845	COG0643	Histidine kinase
IXO639_RS15850	COG0840	transmembrane signaling receptor activity
IXO639_RS15855	COG0835	chemotaxis
IXO639_RS15860	COG2199	diguanylate cyclase activity
IXO639_RS15860	COG2200	EAL domain
IXO639_RS15860	COG2202	Pas domain
IXO639_RS15865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO639_RS15880	COG3590	peptidase
IXO639_RS15895	COG0588	phosphoglycerate mutase activity
IXO639_RS15900	COG1515	deoxyribonuclease V activity
IXO639_RS15910	COG1741	Belongs to the pirin family
IXO639_RS15975	COG1741	Belongs to the pirin family
IXO639_RS15980	COG1966	Carbon starvation protein
IXO639_RS15985	COG2879	small protein
IXO639_RS16025	COG4251	negative regulation of phosphorylation
IXO639_RS16025	COG5001	Diguanylate cyclase
IXO639_RS16025	COG3706	GGDEF domain
IXO639_RS16025	COG2203	Gaf domain
IXO639_RS16030	COG0629	single-stranded DNA binding
IXO639_RS16035	COG0142	geranyltranstransferase activity
IXO639_RS16060	COG0527	aspartate kinase activity
IXO639_RS16070	COG0384	phenazine biosynthesis protein PhzF
IXO639_RS16080	COG1764	response to oxidative stress
IXO639_RS16095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO639_RS16100	COG1678	Uncharacterized ACR, COG1678
IXO639_RS16115	COG0519	Catalyzes the synthesis of GMP from XMP
IXO639_RS16145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO639_RS16205	COG1959	2 iron, 2 sulfur cluster binding
IXO639_RS16210	COG0719	Fe-S assembly protein
IXO639_RS16215	COG0396	ATPase activity
IXO639_RS16220	COG0719	Fe-S assembly protein
IXO639_RS16225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO639_RS16235	COG2146	nitrite reductase [NAD(P)H] activity
IXO639_RS16260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO639_RS16275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO639_RS16285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO639_RS16290	COG0174	glutamine synthetase
IXO639_RS16295	COG3328	transposase activity
IXO639_RS16320	COG0326	Molecular chaperone. Has ATPase activity
IXO639_RS16325	COG2207	Transcriptional regulator
IXO639_RS16355	COG0657	acetylesterase activity
IXO639_RS16355	COG2755	lipolytic protein G-D-S-L family
IXO639_RS16380	COG0488	(ABC) transporter
IXO639_RS16410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO639_RS16410	COG4651	solute:proton antiporter activity
IXO639_RS16425	COG4772	TonB-dependent receptor
IXO639_RS16435	COG4264	IucA IucC family
IXO639_RS16440	COG2814	Major facilitator Superfamily
IXO639_RS16450	COG0019	diaminopimelate decarboxylase activity
IXO639_RS16515	COG4206	TonB-dependent receptor
IXO639_RS16550	COG0542	response to heat
IXO639_RS16590	COG0534	Mate efflux family protein
IXO639_RS16605	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO639_RS16610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO639_RS16615	COG0228	four-way junction DNA binding
IXO639_RS16635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO639_RS16645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO639_RS16690	COG1555	photosystem II stabilization
IXO639_RS16695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO639_RS16710	COG3178	'Phosphotransferase
IXO639_RS16715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO639_RS16725	COG0628	permease
IXO639_RS16735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO639_RS16750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO639_RS16770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO639_RS16775	COG0271	Belongs to the BolA IbaG family
IXO639_RS16785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO639_RS16795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO639_RS16800	COG1137	ATPase activity
IXO639_RS16815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO639_RS16820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO639_RS16825	COG1660	Displays ATPase and GTPase activities
IXO639_RS16835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO639_RS16840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO639_RS16845	COG2239	Acts as a magnesium transporter
IXO639_RS16855	COG1294	oxidase, subunit
IXO639_RS16860	COG1271	oxidase subunit
IXO639_RS16875	COG1113	amino acid transport
IXO639_RS16890	COG2197	response regulator
IXO639_RS16895	COG0531	amino acid
IXO639_RS16955	COG0754	glutathionylspermidine amidase activity
IXO639_RS16980	COG1842	Phage shock protein A
IXO639_RS16995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO639_RS17000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO639_RS17010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO639_RS17040	COG2201	protein-glutamate methylesterase activity
IXO639_RS17090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO639_RS17140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO639_RS17145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO639_RS17175	COG3039	Transposase
IXO639_RS17190	COG0745	RESPONSE REGULATOR receiver
IXO639_RS17195	COG2205	protein histidine kinase activity
IXO639_RS17215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO639_RS17245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO639_RS17245	COG3453	Protein conserved in bacteria
IXO639_RS17250	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO639_RS17255	COG4149	molybdate abc transporter
IXO639_RS17260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO639_RS17280	COG0642	Histidine kinase
IXO639_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS17305	COG1022	Amp-dependent synthetase and ligase
IXO639_RS17330	COG1376	ErfK ybiS ycfS ynhG family protein
IXO639_RS17335	COG0739	heme binding
IXO639_RS17345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO639_RS17350	COG1301	dicarboxylic acid transport
IXO639_RS17370	COG2304	oxidoreductase activity
IXO639_RS17390	COG0714	Associated with various cellular activities
IXO639_RS17435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO639_RS17460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO639_RS17470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO639_RS17495	COG1561	YicC-like family, N-terminal region
IXO639_RS17500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO639_RS17515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO639_RS17550	COG0006	proline dipeptidase activity
IXO639_RS17575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO639_RS17585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO639_RS17595	COG2912	Transglutaminase-like superfamily
IXO639_RS17600	COG1773	rubredoxin
IXO639_RS17605	COG0352	thiamine-phosphate diphosphorylase activity
IXO639_RS17670	COG0281	malic enzyme
IXO639_RS17670	COG0280	phosphate acetyltransferase
IXO639_RS17690	COG4191	Histidine kinase
IXO639_RS17705	COG0583	DNA-binding transcription factor activity
IXO639_RS17725	COG2197	response regulator
IXO639_RS17735	COG0642	Histidine kinase
IXO639_RS17750	COG2851	Citrate transporter
IXO639_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS17760	COG1609	Transcriptional regulator
IXO639_RS17770	COG2211	Major facilitator Superfamily
IXO639_RS17795	COG1162	GTPase activity
IXO639_RS17820	COG0726	polysaccharide deacetylase
IXO639_RS17825	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO639_RS17850	COG3039	Transposase
IXO639_RS17855	COG3039	Transposase
IXO639_RS17900	COG0242	peptide deformylase activity
IXO639_RS17920	COG0714	Associated with various cellular activities
IXO639_RS17940	COG0537	adenosine 5'-monophosphoramidase activity
IXO639_RS17970	COG0314	molybdopterin synthase activity
IXO639_RS17975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO639_RS17980	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO639_RS17990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO639_RS17995	COG1234	tRNA 3'-trailer cleavage
IXO639_RS18000	COG3642	lipopolysaccharide core region biosynthetic process
IXO639_RS18005	COG0859	PFAM glycosyl transferase family 9
IXO639_RS18015	COG0582	viral genome integration into host DNA
IXO639_RS18075	COG0631	protein serine/threonine phosphatase activity
IXO639_RS18085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO639_RS18110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO639_RS18150	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO639_RS18200	COG0473	3-isopropylmalate dehydrogenase activity
IXO639_RS18225	COG4783	chaperone-mediated protein folding
IXO639_RS18240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO639_RS18250	COG0438	transferase activity, transferring glycosyl groups
IXO639_RS18255	COG0671	phosphoesterase, PA-phosphatase related
IXO639_RS18260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO639_RS18280	COG2833	Protein of unknown function (DUF455)
IXO639_RS18300	COG0285	dihydrofolate synthase activity
IXO639_RS18310	COG0588	phosphoglycerate mutase activity
IXO639_RS18340	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO639_RS18345	COG4208	sulfate ABC transporter
IXO639_RS18350	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO639_RS18355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO639_RS18360	COG0156	8-amino-7-oxononanoate synthase activity
IXO639_RS18385	COG0604	alcohol dehydrogenase
IXO639_RS18390	COG1902	pentaerythritol trinitrate reductase activity
IXO639_RS18390	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO639_RS18515	COG3386	PFAM SMP-30 Gluconolaconase
IXO639_RS18535	COG1024	Enoyl-CoA hydratase
IXO639_RS18545	COG0318	PFAM AMP-dependent synthetase and ligase
IXO639_RS18550	COG0583	DNA-binding transcription factor activity
IXO639_RS18590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO639_RS18595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO639_RS18605	COG2096	Adenosyltransferase
IXO639_RS18610	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO639_RS18625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO639_RS18635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO639_RS18640	COG2967	ApaG domain
IXO639_RS18665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO639_RS18685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO639_RS18705	COG0642	Histidine kinase
IXO639_RS18720	COG4181	ATPase activity
IXO639_RS18730	COG2175	clavaminate synthase activity
IXO639_RS18785	COG0667	Aldo Keto reductase
IXO639_RS18795	COG3039	Transposase
IXO639_RS18805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO639_RS18810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_RS18820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO639_RS18835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO639_RS18880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO639_RS18885	COG2226	methyltransferase
IXO639_RS18930	COG3321	synthase
IXO639_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS18930	COG0604	alcohol dehydrogenase
IXO639_RS18940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO639_RS18955	COG0494	nUDIX hydrolase
IXO639_RS18970	COG1388	LysM domain
IXO639_RS18970	COG4942	peptidase
IXO639_RS18980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO639_RS18995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO639_RS19000	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO639_RS19005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO639_RS19020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO639_RS19025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO639_RS19040	COG3116	cell division
IXO639_RS19045	COG0275	rRNA processing
IXO639_RS19080	COG0792	nuclease activity
IXO639_RS19085	COG1988	membrane-bound metal-dependent
IXO639_RS19090	COG0277	FAD linked oxidase domain protein
IXO639_RS19095	COG0745	RESPONSE REGULATOR receiver
IXO639_RS19100	COG2205	protein histidine kinase activity
IXO639_RS19110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO639_RS19115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO639_RS19135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO639_RS19140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO639_RS19145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO639_RS19165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO639_RS19165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO639_RS19185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO639_RS19205	COG0488	(ABC) transporter
IXO639_RS19215	COG3039	Transposase
IXO639_RS19235	COG3791	Glutathione-dependent formaldehyde-activating
IXO639_RS19265	COG2205	protein histidine kinase activity
IXO639_RS19325	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO639_RS19360	COG3039	Transposase
IXO639_RS19385	COG3039	Transposase
IXO639_RS19465	COG1649	PFAM Uncharacterised BCR, COG1649
IXO639_RS19465	COG0726	polysaccharide deacetylase
IXO639_RS19470	COG1215	transferase activity, transferring glycosyl groups
IXO639_RS19480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO639_RS19485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO639_RS19490	COG1609	Transcriptional regulator
IXO639_RS19500	COG2188	Transcriptional regulator
IXO639_RS19515	COG3250	beta-galactosidase activity
IXO639_RS19565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO639_RS19570	COG4191	Histidine kinase
IXO639_RS19575	COG0784	Response regulator, receiver
IXO639_RS19580	COG4251	negative regulation of phosphorylation
IXO639_RS19585	COG2823	Periplasmic or secreted lipoprotein
IXO639_RS19590	COG0673	inositol 2-dehydrogenase activity
IXO639_RS19595	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO639_RS19630	COG1056	cytidyltransferase-related domain
IXO639_RS19630	COG1051	belongs to the nudix hydrolase family
IXO639_RS19655	COG2921	Belongs to the UPF0250 family
IXO639_RS19670	COG1686	Belongs to the peptidase S11 family
IXO639_RS19675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO639_RS19680	COG2951	lytic endotransglycosylase activity
IXO639_RS19750	COG0772	Belongs to the SEDS family
IXO639_RS19765	COG1792	Involved in formation and maintenance of cell shape
IXO639_RS19770	COG1077	Cell shape determining protein MreB Mrl
IXO639_RS19775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_RS19825	COG2199	diguanylate cyclase activity
IXO639_RS19830	COG0308	aminopeptidase N
IXO639_RS19860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO639_RS19890	COG0436	Aminotransferase
IXO639_RS19895	COG3039	Transposase
IXO639_RS19915	COG1505	serine-type exopeptidase activity
IXO639_RS19940	COG0181	hydroxymethylbilane synthase activity
IXO639_RS19950	COG3275	phosphorelay sensor kinase activity
IXO639_RS19985	COG0659	secondary active sulfate transmembrane transporter activity
IXO639_RS19990	COG5297	Belongs to the glycosyl hydrolase family 6
IXO639_RS19990	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_RS20065	COG0598	Magnesium transport protein CorA
IXO639_RS20075	COG1113	amino acid transport
IXO639_RS20085	COG5297	Belongs to the glycosyl hydrolase family 6
IXO639_RS20090	COG4305	rare lipoprotein A
IXO639_RS20095	COG0697	spore germination
IXO639_RS20155	COG4221	oxidoreductase activity
IXO639_RS20185	COG0456	acetyltransferase
IXO639_RS20195	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO639_RS20235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO639_RS20235	COG2111	Na H antiporter
IXO639_RS20240	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO639_RS20245	COG0651	ATP synthesis coupled electron transport
IXO639_RS20255	COG2212	antiporter activity
IXO639_RS20260	COG1320	monovalent cation:proton antiporter activity
IXO639_RS20270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO639_RS20290	COG3104	oligopeptide transport
IXO639_RS20295	COG3483	tryptophan 2,3-dioxygenase activity
IXO639_RS20345	COG0183	Belongs to the thiolase family
IXO639_RS20415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO639_RS20420	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO639_RS20430	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_RS20455	COG0531	amino acid
IXO639_RS20485	COG4682	membrane
IXO639_RS20490	COG2133	pyrroloquinoline quinone binding
IXO639_RS20530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO639_RS20535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO639_RS20545	COG1610	YqeY-like protein
IXO639_RS20555	COG1295	ribonuclease BN
IXO639_RS20560	COG0358	DNA primase activity
IXO639_RS20625	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO639_RS20640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO639_RS20690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO639_RS20695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO639_RS20700	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO639_RS20710	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO639_RS20715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO639_RS20725	COG0134	indole-3-glycerol-phosphate synthase activity
IXO639_RS20730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO639_RS20795	COG3039	Transposase
IXO639_RS20810	COG3039	Transposase
IXO639_RS20835	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO639_RS20835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO639_RS20845	COG1473	amidohydrolase
IXO639_RS20850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_RS20855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO639_RS20865	COG5383	Protein conserved in bacteria
IXO639_RS20900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO639_RS20905	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO639_RS20920	COG0028	Belongs to the TPP enzyme family
IXO639_RS20925	COG4191	Histidine kinase
IXO639_RS20950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO639_RS20965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO639_RS20970	COG3177	Filamentation induced by cAMP protein fic
IXO639_RS20985	COG0596	Alpha beta hydrolase
IXO639_RS20990	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO639_RS20995	COG0318	PFAM AMP-dependent synthetase and ligase
IXO639_RS21000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO639_RS21050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO639_RS21060	COG0129	dihydroxy-acid dehydratase activity
IXO639_RS21080	COG3039	Transposase
IXO639_RS21090	COG0408	coproporphyrinogen oxidase activity
IXO639_RS21130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO639_RS21200	COG2353	YceI-like domain
IXO639_RS21205	COG0778	Nitroreductase
IXO639_RS21255	COG3386	PFAM SMP-30 Gluconolaconase
IXO639_RS21280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO639_RS21300	COG0459	protein refolding
IXO639_RS21325	COG1252	NADH dehydrogenase
IXO639_RS21335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO639_RS21340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO639_RS21345	COG2201	protein-glutamate methylesterase activity
IXO639_RS21350	COG2177	Part of the ABC transporter FtsEX involved in
IXO639_RS21355	COG2884	Cell division ATP-binding protein ftsE
IXO639_RS21365	COG3118	belongs to the thioredoxin family
IXO639_RS21370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO639_RS21385	COG0729	surface antigen
IXO639_RS21390	COG2911	Protein conserved in bacteria
IXO639_RS21440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO639_RS21490	COG1733	regulation of RNA biosynthetic process
IXO639_RS21495	COG0702	epimerase
IXO639_RS21525	COG0583	DNA-binding transcription factor activity
IXO639_RS21530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO639_RS21550	COG0745	RESPONSE REGULATOR receiver
IXO639_RS21580	COG1902	pentaerythritol trinitrate reductase activity
IXO639_RS21585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO639_RS21595	COG2814	Major facilitator Superfamily
IXO639_RS21600	COG0583	DNA-binding transcription factor activity
IXO639_RS21615	COG0084	hydrolase, TatD family'
IXO639_RS21660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO639_RS21685	COG2351	hydroxyisourate hydrolase activity
IXO639_RS21745	COG4770	biotin carboxylase activity
IXO639_RS21750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO639_RS21755	COG1960	acyl-CoA dehydrogenase activity
IXO639_RS21810	COG0523	cobalamin synthesis protein
IXO639_RS21830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO639_RS21850	COG4771	TonB-dependent receptor
IXO639_RS21855	COG0457	Tetratricopeptide repeat
IXO639_RS21865	COG0752	glycyl-tRNA synthetase alpha subunit
IXO639_RS21870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO639_RS21885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO639_RS21885	COG0519	Catalyzes the synthesis of GMP from XMP
IXO639_RS21895	COG0805	protein transport
IXO639_RS21905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO639_RS21915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO639_RS21940	COG2974	May be involved in recombination
IXO639_RS21945	COG0037	tRNA processing
IXO639_RS21965	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO639_RS21975	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_RS21985	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO639_RS21990	COG0246	Mannitol dehydrogenase
IXO639_RS22015	COG3693	PFAM glycoside hydrolase, family 10
IXO639_RS22040	COG2211	Major facilitator Superfamily
IXO639_RS22125	COG1846	Transcriptional regulator
IXO639_RS22130	COG1764	response to oxidative stress
IXO639_RS22210	COG3549	Plasmid maintenance system killer
IXO639_RS22220	COG1074	ATP-dependent DNA helicase activity
IXO639_RS22225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO639_RS22240	COG1196	nuclear chromosome segregation
IXO639_RS22275	COG2032	superoxide dismutase activity
IXO639_RS22280	COG2032	superoxide dismutase activity
IXO639_RS22285	COG2204	response regulator
IXO639_RS22290	COG3852	Histidine kinase
IXO639_RS22295	COG0004	ammonium transporteR
IXO639_RS22300	COG0347	Belongs to the P(II) protein family
IXO639_RS22305	COG0174	glutamine synthetase
IXO639_RS22310	COG1968	undecaprenyl-diphosphatase activity
IXO639_RS22350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO639_RS22360	COG2062	phosphohistidine phosphatase, SixA
IXO639_RS22365	COG0489	protein tyrosine kinase activity
IXO639_RS22385	COG1396	sequence-specific DNA binding
IXO639_RS22390	COG3550	peptidyl-serine autophosphorylation
IXO639_RS22395	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO639_RS22400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_RS22415	COG0517	IMP dehydrogenase activity
IXO639_RS22415	COG1125	glycine betaine transport
IXO639_RS22430	COG1119	ATPase activity
IXO639_RS22440	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO639_RS22455	COG3039	Transposase
IXO639_RS22480	COG0656	L-ascorbic acid biosynthetic process
IXO639_RS22485	COG2130	NADP-dependent
IXO639_RS22490	COG0667	Aldo Keto reductase
IXO639_RS22500	COG1187	pseudouridine synthase activity
IXO639_RS22510	COG1643	Atp-dependent helicase
IXO639_RS22515	COG4807	Protein conserved in bacteria
IXO639_RS22520	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_RS22525	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO639_RS22530	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_RS22590	COG3162	membrane
IXO639_RS22595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO639_RS22610	COG0708	Exodeoxyribonuclease III
IXO639_RS22625	COG2091	lysine biosynthetic process via aminoadipic acid
IXO639_RS22635	COG3540	Alkaline phosphatase
IXO639_RS22640	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO639_RS22660	COG2159	amidohydrolase
IXO639_RS22670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO639_RS22675	COG0583	DNA-binding transcription factor activity
IXO639_RS22680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO639_RS22695	COG0210	DNA helicase
IXO639_RS22715	COG0531	amino acid
IXO639_RS22725	COG1322	Protein conserved in bacteria
IXO639_RS22735	COG0386	Belongs to the glutathione peroxidase family
IXO639_RS22790	COG0793	Belongs to the peptidase S41A family
IXO639_RS22795	COG4942	peptidase
IXO639_RS22805	COG2234	aminopeptidase activity
IXO639_RS22850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO639_RS22855	COG0302	gtp cyclohydrolase
IXO639_RS22875	COG0477	Major facilitator Superfamily
IXO639_RS22955	COG1929	Belongs to the glycerate kinase type-1 family
IXO639_RS22960	COG2271	Major facilitator Superfamily
IXO639_RS22975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO639_RS22980	COG0861	Integral membrane protein TerC family
IXO639_RS22995	COG0584	glycerophosphoryl diester phosphodiesterase
IXO639_RS23005	COG0671	phosphoesterase, PA-phosphatase related
IXO639_RS23010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO639_RS23015	COG0726	polysaccharide deacetylase