locus-tag	class	description
IXO685_RS00040	COG2201	protein-glutamate methylesterase activity
IXO685_RS00095	COG0322	excinuclease ABC activity
IXO685_RS00105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO685_RS00115	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO685_RS00130	COG0811	peptide transport
IXO685_RS00155	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO685_RS00170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO685_RS00185	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO685_RS00200	COG0354	folic acid binding
IXO685_RS00215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO685_RS00225	COG0363	glucosamine-6-phosphate deaminase activity
IXO685_RS00230	COG0129	dihydroxy-acid dehydratase activity
IXO685_RS00235	COG0800	Aldolase
IXO685_RS00275	COG0784	Response regulator, receiver
IXO685_RS00275	COG2205	protein histidine kinase activity
IXO685_RS00275	COG5002	protein histidine kinase activity
IXO685_RS00300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO685_RS00305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IXO685_RS00310	COG0431	NADPH-dependent FMN reductase
IXO685_RS00315	COG1393	Belongs to the ArsC family
IXO685_RS00320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO685_RS00340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO685_RS00365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IXO685_RS00385	COG1247	-acetyltransferase
IXO685_RS00465	COG0386	Belongs to the glutathione peroxidase family
IXO685_RS00550	COG2203	Gaf domain
IXO685_RS00550	COG3706	GGDEF domain
IXO685_RS00550	COG4251	negative regulation of phosphorylation
IXO685_RS00550	COG5001	Diguanylate cyclase
IXO685_RS00565	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO685_RS00595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO685_RS00600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO685_RS00610	COG0617	tRNA 3'-terminal CCA addition
IXO685_RS00620	COG1469	GTP cyclohydrolase I activity
IXO685_RS00625	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO685_RS00670	COG4566	intracellular signal transduction
IXO685_RS00700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO685_RS00705	COG1605	Chorismate mutase
IXO685_RS00705	COG0077	Prephenate dehydratase
IXO685_RS00715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO685_RS00760	COG1228	amidohydrolase
IXO685_RS00765	COG2986	histidine ammonia-lyase
IXO685_RS00775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO685_RS00800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO685_RS00815	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO685_RS00835	COG3115	cell septum assembly
IXO685_RS00845	COG0359	binds to the 23S rRNA
IXO685_RS00855	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO685_RS00860	COG0316	Belongs to the HesB IscA family
IXO685_RS00890	COG0288	reversible hydration of carbon dioxide
IXO685_RS00915	COG2925	Exonuclease
IXO685_RS00925	COG0667	Aldo Keto reductase
IXO685_RS00950	COG0116	Belongs to the methyltransferase superfamily
IXO685_RS00950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO685_RS00995	COG0494	nUDIX hydrolase
IXO685_RS01010	COG1024	Enoyl-CoA hydratase
IXO685_RS01020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO685_RS01055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO685_RS01060	COG0573	inorganic phosphate transmembrane transporter activity
IXO685_RS01075	COG0704	Plays a role in the regulation of phosphate uptake
IXO685_RS01085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO685_RS01100	COG3328	transposase activity
IXO685_RS01120	COG3039	Transposase
IXO685_RS01130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO685_RS01135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO685_RS01140	COG1862	Preprotein translocase
IXO685_RS01145	COG0343	queuine tRNA-ribosyltransferase activity
IXO685_RS01185	COG3039	Transposase
IXO685_RS01230	COG3409	Peptidoglycan-binding domain 1 protein
IXO685_RS01230	COG3501	Rhs element vgr protein
IXO685_RS01270	COG3039	Transposase
IXO685_RS01310	COG1192	Involved in chromosome partitioning
IXO685_RS01325	COG4771	TonB-dependent receptor
IXO685_RS01335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO685_RS01355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO685_RS01370	COG0835	chemotaxis
IXO685_RS01380	COG0745	RESPONSE REGULATOR receiver
IXO685_RS01410	COG0840	transmembrane signaling receptor activity
IXO685_RS01420	COG0840	transmembrane signaling receptor activity
IXO685_RS01430	COG0840	transmembrane signaling receptor activity
IXO685_RS01435	COG0840	transmembrane signaling receptor activity
IXO685_RS01440	COG0840	transmembrane signaling receptor activity
IXO685_RS01445	COG0840	transmembrane signaling receptor activity
IXO685_RS01460	COG0835	chemotaxis
IXO685_RS01520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO685_RS01550	COG0318	PFAM AMP-dependent synthetase and ligase
IXO685_RS01555	COG1024	Enoyl-CoA hydratase
IXO685_RS01560	COG0784	Response regulator, receiver
IXO685_RS01560	COG2198	Histidine kinase
IXO685_RS01560	COG2205	protein histidine kinase activity
IXO685_RS01570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IXO685_RS01635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO685_RS01645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO685_RS01650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO685_RS01660	COG0505	Belongs to the CarA family
IXO685_RS01665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO685_RS01675	COG2258	MOSC domain
IXO685_RS01680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO685_RS01725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO685_RS01745	COG0477	Major facilitator Superfamily
IXO685_RS01755	COG1070	Carbohydrate kinase
IXO685_RS01765	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO685_RS01780	COG0800	Aldolase
IXO685_RS01785	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_RS01795	COG3734	2-keto-3-deoxy-galactonokinase
IXO685_RS01800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO685_RS01810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO685_RS01825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO685_RS01830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO685_RS01840	COG0351	phosphomethylpyrimidine kinase
IXO685_RS01865	COG0583	DNA-binding transcription factor activity
IXO685_RS01870	COG1741	Belongs to the pirin family
IXO685_RS01895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO685_RS01900	COG0305	Participates in initiation and elongation during chromosome replication
IXO685_RS01920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO685_RS01925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO685_RS01930	COG2137	regulation of response to DNA damage stimulus
IXO685_RS01935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO685_RS01950	COG1546	Belongs to the CinA family
IXO685_RS01955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO685_RS01965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO685_RS01970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO685_RS01980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO685_RS01985	COG1534	Rna-binding protein
IXO685_RS02000	COG1238	metal cluster binding
IXO685_RS02005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO685_RS02010	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO685_RS02015	COG2840	Smr protein MutS2
IXO685_RS02025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO685_RS02035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO685_RS02040	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO685_RS02045	COG0148	phosphopyruvate hydratase activity
IXO685_RS02055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO685_RS02060	COG0504	CTP synthase activity
IXO685_RS02090	COG0306	phosphate transporter
IXO685_RS02100	COG1253	flavin adenine dinucleotide binding
IXO685_RS02115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO685_RS02125	COG0477	Major facilitator Superfamily
IXO685_RS02135	COG1132	(ABC) transporter
IXO685_RS02140	COG1136	(ABC) transporter
IXO685_RS02155	COG0438	transferase activity, transferring glycosyl groups
IXO685_RS02165	COG2264	protein methyltransferase activity
IXO685_RS02195	COG2244	polysaccharide biosynthetic process
IXO685_RS02245	COG1595	DNA-templated transcription, initiation
IXO685_RS02260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO685_RS02280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO685_RS02325	COG2201	protein-glutamate methylesterase activity
IXO685_RS02345	COG2201	protein-glutamate methylesterase activity
IXO685_RS02370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_RS02425	COG1858	cytochrome C peroxidase
IXO685_RS02455	COG0515	serine threonine protein kinase
IXO685_RS02460	COG0631	protein serine/threonine phosphatase activity
IXO685_RS02565	COG3039	Transposase
IXO685_RS02600	COG3039	Transposase
IXO685_RS02605	COG3039	Transposase
IXO685_RS02630	COG0316	Belongs to the HesB IscA family
IXO685_RS02630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO685_RS02635	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO685_RS02650	COG3064	Membrane
IXO685_RS02660	COG1530	ribonuclease E activity
IXO685_RS02675	COG1054	Belongs to the UPF0176 family
IXO685_RS02695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO685_RS02730	COG3039	Transposase
IXO685_RS02760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO685_RS02760	COG1648	precorrin-2 dehydrogenase activity
IXO685_RS02785	COG0746	molybdenum cofactor guanylyltransferase activity
IXO685_RS02810	COG3039	Transposase
IXO685_RS02870	COG4206	TonB-dependent receptor
IXO685_RS02900	COG0531	amino acid
IXO685_RS02915	COG0006	proline dipeptidase activity
IXO685_RS02925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO685_RS02940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_RS02945	COG3938	Belongs to the proline racemase family
IXO685_RS02955	COG0552	protein localization to endoplasmic reticulum
IXO685_RS02975	COG4191	Histidine kinase
IXO685_RS02975	COG0784	Response regulator, receiver
IXO685_RS03060	COG3040	lipid binding
IXO685_RS03100	COG0438	transferase activity, transferring glycosyl groups
IXO685_RS03110	COG0438	transferase activity, transferring glycosyl groups
IXO685_RS03115	COG0438	transferase activity, transferring glycosyl groups
IXO685_RS03170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO685_RS03175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IXO685_RS03185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO685_RS03225	COG0556	nucleotide-excision repair
IXO685_RS03230	COG4969	Belongs to the N-Me-Phe pilin family
IXO685_RS03305	COG4695	Portal protein
IXO685_RS03350	COG3179	chitinase
IXO685_RS03445	COG1192	Involved in chromosome partitioning
IXO685_RS03565	COG1611	Belongs to the LOG family
IXO685_RS03580	COG2095	MarC family integral membrane protein
IXO685_RS03590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO685_RS03625	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO685_RS03630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO685_RS03650	COG0195	Participates in both transcription termination and antitermination
IXO685_RS03655	COG0779	Required for maturation of 30S ribosomal subunits
IXO685_RS03665	COG1007	ATP synthesis coupled electron transport
IXO685_RS03695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO685_RS03700	COG1034	ATP synthesis coupled electron transport
IXO685_RS03705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO685_RS03710	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO685_RS03715	COG0649	NAD binding
IXO685_RS03720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO685_RS03730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO685_RS03745	COG0149	triose-phosphate isomerase activity
IXO685_RS03795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO685_RS03800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO685_RS03805	COG0159	tryptophan synthase activity
IXO685_RS03815	COG0133	tryptophan synthase activity
IXO685_RS03825	COG0135	phosphoribosylanthranilate isomerase activity
IXO685_RS03830	COG0101	tRNA pseudouridine synthase activity
IXO685_RS03850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO685_RS03855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO685_RS03860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO685_RS03865	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO685_RS03990	COG3039	Transposase
IXO685_RS04010	COG3179	chitinase
IXO685_RS04065	COG1741	Belongs to the pirin family
IXO685_RS04070	COG1966	Carbon starvation protein
IXO685_RS04075	COG2879	small protein
IXO685_RS04110	COG4251	negative regulation of phosphorylation
IXO685_RS04110	COG2203	Gaf domain
IXO685_RS04110	COG5001	Diguanylate cyclase
IXO685_RS04110	COG3706	GGDEF domain
IXO685_RS04115	COG0629	single-stranded DNA binding
IXO685_RS04120	COG0142	geranyltranstransferase activity
IXO685_RS04145	COG0527	aspartate kinase activity
IXO685_RS04155	COG0384	phenazine biosynthesis protein PhzF
IXO685_RS04165	COG1764	response to oxidative stress
IXO685_RS04180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO685_RS04185	COG1678	Uncharacterized ACR, COG1678
IXO685_RS04200	COG0519	Catalyzes the synthesis of GMP from XMP
IXO685_RS04230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO685_RS04290	COG1959	2 iron, 2 sulfur cluster binding
IXO685_RS04295	COG0719	Fe-S assembly protein
IXO685_RS04300	COG0396	ATPase activity
IXO685_RS04305	COG0719	Fe-S assembly protein
IXO685_RS04310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO685_RS04325	COG2146	nitrite reductase [NAD(P)H] activity
IXO685_RS04360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO685_RS04375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO685_RS04385	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO685_RS04390	COG0174	glutamine synthetase
IXO685_RS04395	COG3328	transposase activity
IXO685_RS04420	COG0326	Molecular chaperone. Has ATPase activity
IXO685_RS04425	COG2207	Transcriptional regulator
IXO685_RS04450	COG0657	acetylesterase activity
IXO685_RS04450	COG2755	lipolytic protein G-D-S-L family
IXO685_RS04475	COG0488	(ABC) transporter
IXO685_RS04500	COG4651	solute:proton antiporter activity
IXO685_RS04500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO685_RS04515	COG4772	TonB-dependent receptor
IXO685_RS04525	COG4264	IucA IucC family
IXO685_RS04530	COG2814	Major facilitator Superfamily
IXO685_RS04540	COG0019	diaminopimelate decarboxylase activity
IXO685_RS04605	COG4206	TonB-dependent receptor
IXO685_RS04640	COG0542	response to heat
IXO685_RS04665	COG3039	Transposase
IXO685_RS04680	COG0534	Mate efflux family protein
IXO685_RS04695	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO685_RS04700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO685_RS04705	COG0228	four-way junction DNA binding
IXO685_RS04725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO685_RS04745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO685_RS04790	COG1555	photosystem II stabilization
IXO685_RS04795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO685_RS04810	COG3178	'Phosphotransferase
IXO685_RS04815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO685_RS04825	COG0628	permease
IXO685_RS04835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO685_RS04850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO685_RS04870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO685_RS04875	COG0271	Belongs to the BolA IbaG family
IXO685_RS04885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO685_RS04895	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO685_RS04900	COG1137	ATPase activity
IXO685_RS04915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO685_RS04920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO685_RS04925	COG1660	Displays ATPase and GTPase activities
IXO685_RS04940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO685_RS04945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO685_RS04950	COG2239	Acts as a magnesium transporter
IXO685_RS04960	COG1294	oxidase, subunit
IXO685_RS04965	COG1271	oxidase subunit
IXO685_RS04980	COG1113	amino acid transport
IXO685_RS04995	COG2197	response regulator
IXO685_RS05000	COG0531	amino acid
IXO685_RS05060	COG0754	glutathionylspermidine amidase activity
IXO685_RS05085	COG1842	Phage shock protein A
IXO685_RS05100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO685_RS05190	COG2201	protein-glutamate methylesterase activity
IXO685_RS05210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO685_RS05260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO685_RS05265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO685_RS05295	COG3039	Transposase
IXO685_RS05320	COG0745	RESPONSE REGULATOR receiver
IXO685_RS05325	COG2205	protein histidine kinase activity
IXO685_RS05345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO685_RS05385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO685_RS05385	COG3453	Protein conserved in bacteria
IXO685_RS05390	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO685_RS05395	COG4149	molybdate abc transporter
IXO685_RS05400	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO685_RS05420	COG0642	Histidine kinase
IXO685_RS05435	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS05445	COG1022	Amp-dependent synthetase and ligase
IXO685_RS05470	COG1376	ErfK ybiS ycfS ynhG family protein
IXO685_RS05475	COG0739	heme binding
IXO685_RS05485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO685_RS05490	COG1301	dicarboxylic acid transport
IXO685_RS05510	COG2304	oxidoreductase activity
IXO685_RS05530	COG0714	Associated with various cellular activities
IXO685_RS05580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO685_RS05605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO685_RS05615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO685_RS05640	COG1561	YicC-like family, N-terminal region
IXO685_RS05645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO685_RS05660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO685_RS05695	COG0006	proline dipeptidase activity
IXO685_RS05720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO685_RS05730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO685_RS05740	COG2912	Transglutaminase-like superfamily
IXO685_RS05745	COG1773	rubredoxin
IXO685_RS05750	COG0352	thiamine-phosphate diphosphorylase activity
IXO685_RS05810	COG0280	phosphate acetyltransferase
IXO685_RS05810	COG0281	malic enzyme
IXO685_RS05830	COG4191	Histidine kinase
IXO685_RS05845	COG0583	DNA-binding transcription factor activity
IXO685_RS05865	COG2197	response regulator
IXO685_RS05875	COG0642	Histidine kinase
IXO685_RS05890	COG2851	Citrate transporter
IXO685_RS05895	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS05900	COG1609	Transcriptional regulator
IXO685_RS05910	COG2211	Major facilitator Superfamily
IXO685_RS05960	COG0726	polysaccharide deacetylase
IXO685_RS05965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO685_RS06015	COG0242	peptide deformylase activity
IXO685_RS06035	COG0714	Associated with various cellular activities
IXO685_RS06055	COG0537	adenosine 5'-monophosphoramidase activity
IXO685_RS06085	COG0314	molybdopterin synthase activity
IXO685_RS06090	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO685_RS06095	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO685_RS06105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO685_RS06110	COG1234	tRNA 3'-trailer cleavage
IXO685_RS06115	COG3642	lipopolysaccharide core region biosynthetic process
IXO685_RS06120	COG0859	PFAM glycosyl transferase family 9
IXO685_RS06130	COG0582	viral genome integration into host DNA
IXO685_RS06170	COG3501	Rhs element vgr protein
IXO685_RS06195	COG0631	protein serine/threonine phosphatase activity
IXO685_RS06205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO685_RS06230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO685_RS06270	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO685_RS06320	COG0473	3-isopropylmalate dehydrogenase activity
IXO685_RS06345	COG4783	chaperone-mediated protein folding
IXO685_RS06360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO685_RS06370	COG0438	transferase activity, transferring glycosyl groups
IXO685_RS06375	COG0671	phosphoesterase, PA-phosphatase related
IXO685_RS06380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO685_RS06400	COG2833	Protein of unknown function (DUF455)
IXO685_RS06420	COG0285	dihydrofolate synthase activity
IXO685_RS06430	COG0588	phosphoglycerate mutase activity
IXO685_RS06465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO685_RS06470	COG4208	sulfate ABC transporter
IXO685_RS06475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO685_RS06480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO685_RS06485	COG0156	8-amino-7-oxononanoate synthase activity
IXO685_RS06510	COG0604	alcohol dehydrogenase
IXO685_RS06515	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO685_RS06515	COG1902	pentaerythritol trinitrate reductase activity
IXO685_RS06550	COG0584	glycerophosphoryl diester phosphodiesterase
IXO685_RS06570	COG3039	Transposase
IXO685_RS06595	COG0625	glutathione transferase activity
IXO685_RS06600	COG0039	L-malate dehydrogenase activity
IXO685_RS06605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO685_RS06610	COG1217	gtp-binding protein TYPA
IXO685_RS06630	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO685_RS06780	COG3781	membrane
IXO685_RS06790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO685_RS06820	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO685_RS06840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO685_RS06865	COG3710	Transcriptional regulator
IXO685_RS06870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO685_RS06880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO685_RS06915	COG0066	3-isopropylmalate dehydratase activity
IXO685_RS06920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO685_RS06950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO685_RS06955	COG1538	Outer membrane efflux protein
IXO685_RS06960	COG1519	Transferase
IXO685_RS06965	COG1560	Kdo2-lipid A biosynthetic process
IXO685_RS07015	COG0308	aminopeptidase N
IXO685_RS07020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO685_RS07030	COG0330	HflC and HflK could
IXO685_RS07035	COG0330	HflC and HflK could
IXO685_RS07055	COG0678	peroxiredoxin activity
IXO685_RS07065	COG2826	transposase and inactivated derivatives, IS30 family
IXO685_RS07095	COG3039	Transposase
IXO685_RS07145	COG3829	transcription factor binding
IXO685_RS07180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO685_RS07185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO685_RS07195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO685_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS07225	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO685_RS07265	COG1518	maintenance of DNA repeat elements
IXO685_RS07270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO685_RS07315	COG2188	Transcriptional regulator
IXO685_RS07330	COG1450	Type ii and iii secretion system protein
IXO685_RS07345	COG3166	PFAM Fimbrial assembly family protein
IXO685_RS07350	COG3156	type II secretion system protein K
IXO685_RS07355	COG4795	General secretion pathway protein
IXO685_RS07360	COG2165	general secretion pathway protein
IXO685_RS07365	COG4970	Tfp pilus assembly protein FimT
IXO685_RS07370	COG2165	general secretion pathway protein
IXO685_RS07375	COG1459	type II secretion system
IXO685_RS07385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO685_RS07395	COG5295	Hep Hag repeat protein
IXO685_RS07405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO685_RS07410	COG4974	Belongs to the 'phage' integrase family
IXO685_RS07425	COG0795	lipopolysaccharide-transporting ATPase activity
IXO685_RS07435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO685_RS07450	COG0525	valine-tRNA ligase activity
IXO685_RS07480	COG3039	Transposase
IXO685_RS07505	COG3039	Transposase
IXO685_RS07535	COG1183	phosphatidylcholine synthase activity
IXO685_RS07545	COG0442	prolyl-tRNA aminoacylation
IXO685_RS07560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO685_RS07565	COG1127	ABC transporter
IXO685_RS07570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO685_RS07570	COG3218	ABC-type transport auxiliary lipoprotein component
IXO685_RS07605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO685_RS07610	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO685_RS07610	COG0662	Cupin 2, conserved barrel domain protein
IXO685_RS07635	COG2086	electron transfer activity
IXO685_RS07650	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO685_RS07650	COG0546	phosphoglycolate phosphatase activity
IXO685_RS07655	COG0277	FAD linked oxidase domain protein
IXO685_RS07670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO685_RS07675	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IXO685_RS07710	COG1216	Glycosyl transferase, family 2
IXO685_RS07710	COG0438	transferase activity, transferring glycosyl groups
IXO685_RS07735	COG0626	cystathionine gamma-synthase activity
IXO685_RS07765	COG0625	glutathione transferase activity
IXO685_RS07775	COG0513	Belongs to the DEAD box helicase family
IXO685_RS07780	COG0720	synthase
IXO685_RS07790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO685_RS07795	COG1956	GAF domain-containing protein
IXO685_RS07830	COG0339	signal peptide processing
IXO685_RS07880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO685_RS07885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_RS07940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO685_RS07945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO685_RS07950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO685_RS07960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO685_RS07970	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO685_RS07990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO685_RS08000	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO685_RS08030	COG2011	ABC-type metal ion transport system permease component
IXO685_RS08040	COG0697	spore germination
IXO685_RS08075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO685_RS08080	COG1187	pseudouridine synthase activity
IXO685_RS08085	COG2813	Specifically methylates the guanine in position
IXO685_RS08115	COG2205	protein histidine kinase activity
IXO685_RS08115	COG2202	Pas domain
IXO685_RS08140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_RS08190	COG0745	RESPONSE REGULATOR receiver
IXO685_RS08205	COG1404	Belongs to the peptidase S8 family
IXO685_RS08225	COG0842	Transport permease protein
IXO685_RS08230	COG1131	(ABC) transporter
IXO685_RS08235	COG0025	NhaP-type Na H and K H
IXO685_RS08250	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO685_RS08260	COG1573	uracil-dna glycosylase
IXO685_RS08270	COG3384	dioxygenase
IXO685_RS08285	COG0667	Aldo Keto reductase
IXO685_RS08300	COG3590	peptidase
IXO685_RS08320	COG0531	amino acid
IXO685_RS08380	COG2204	response regulator
IXO685_RS08390	COG1271	oxidase subunit
IXO685_RS08395	COG1294	oxidase, subunit
IXO685_RS08420	COG3039	Transposase
IXO685_RS08480	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO685_RS08495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO685_RS08545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO685_RS08550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO685_RS08555	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO685_RS08565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO685_RS08570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO685_RS08585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO685_RS08670	COG3328	transposase activity
IXO685_RS08680	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO685_RS08680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO685_RS08690	COG1473	amidohydrolase
IXO685_RS08695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_RS08700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO685_RS08710	COG5383	Protein conserved in bacteria
IXO685_RS08735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO685_RS08740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO685_RS08755	COG0028	Belongs to the TPP enzyme family
IXO685_RS08760	COG4191	Histidine kinase
IXO685_RS08785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO685_RS08800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO685_RS08805	COG3177	Filamentation induced by cAMP protein fic
IXO685_RS08820	COG0596	Alpha beta hydrolase
IXO685_RS08825	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO685_RS08830	COG0318	PFAM AMP-dependent synthetase and ligase
IXO685_RS08835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO685_RS08865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO685_RS08875	COG0129	dihydroxy-acid dehydratase activity
IXO685_RS08895	COG3039	Transposase
IXO685_RS08905	COG0408	coproporphyrinogen oxidase activity
IXO685_RS09010	COG2353	YceI-like domain
IXO685_RS09040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO685_RS09055	COG3386	PFAM SMP-30 Gluconolaconase
IXO685_RS09085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO685_RS09105	COG0459	protein refolding
IXO685_RS09130	COG1252	NADH dehydrogenase
IXO685_RS09140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO685_RS09145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO685_RS09150	COG2201	protein-glutamate methylesterase activity
IXO685_RS09155	COG2177	Part of the ABC transporter FtsEX involved in
IXO685_RS09160	COG2884	Cell division ATP-binding protein ftsE
IXO685_RS09170	COG3118	belongs to the thioredoxin family
IXO685_RS09175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO685_RS09190	COG0729	surface antigen
IXO685_RS09195	COG2911	Protein conserved in bacteria
IXO685_RS09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO685_RS09265	COG3039	Transposase
IXO685_RS09300	COG1733	regulation of RNA biosynthetic process
IXO685_RS09305	COG0702	epimerase
IXO685_RS09335	COG0583	DNA-binding transcription factor activity
IXO685_RS09340	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO685_RS09360	COG0745	RESPONSE REGULATOR receiver
IXO685_RS09390	COG1902	pentaerythritol trinitrate reductase activity
IXO685_RS09395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO685_RS09420	COG0583	DNA-binding transcription factor activity
IXO685_RS09435	COG0084	hydrolase, TatD family'
IXO685_RS09480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO685_RS09555	COG4770	biotin carboxylase activity
IXO685_RS09560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO685_RS09565	COG1960	acyl-CoA dehydrogenase activity
IXO685_RS09615	COG0523	cobalamin synthesis protein
IXO685_RS09635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO685_RS09665	COG4771	TonB-dependent receptor
IXO685_RS09670	COG0457	Tetratricopeptide repeat
IXO685_RS09680	COG0752	glycyl-tRNA synthetase alpha subunit
IXO685_RS09685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO685_RS09700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO685_RS09700	COG0519	Catalyzes the synthesis of GMP from XMP
IXO685_RS09710	COG0805	protein transport
IXO685_RS09720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO685_RS09730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO685_RS09755	COG2974	May be involved in recombination
IXO685_RS09760	COG0037	tRNA processing
IXO685_RS09780	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO685_RS09790	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_RS09800	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO685_RS09805	COG0246	Mannitol dehydrogenase
IXO685_RS09830	COG3693	PFAM glycoside hydrolase, family 10
IXO685_RS09855	COG2211	Major facilitator Superfamily
IXO685_RS09940	COG1846	Transcriptional regulator
IXO685_RS09945	COG1764	response to oxidative stress
IXO685_RS10025	COG3549	Plasmid maintenance system killer
IXO685_RS10035	COG1074	ATP-dependent DNA helicase activity
IXO685_RS10040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO685_RS10050	COG1196	nuclear chromosome segregation
IXO685_RS10085	COG2032	superoxide dismutase activity
IXO685_RS10090	COG2032	superoxide dismutase activity
IXO685_RS10095	COG2204	response regulator
IXO685_RS10100	COG3852	Histidine kinase
IXO685_RS10105	COG0004	ammonium transporteR
IXO685_RS10110	COG0347	Belongs to the P(II) protein family
IXO685_RS10115	COG0174	glutamine synthetase
IXO685_RS10120	COG1968	undecaprenyl-diphosphatase activity
IXO685_RS10160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO685_RS10170	COG2062	phosphohistidine phosphatase, SixA
IXO685_RS10175	COG0489	protein tyrosine kinase activity
IXO685_RS10195	COG1396	sequence-specific DNA binding
IXO685_RS10200	COG3550	peptidyl-serine autophosphorylation
IXO685_RS10205	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO685_RS10210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO685_RS10225	COG0517	IMP dehydrogenase activity
IXO685_RS10225	COG1125	glycine betaine transport
IXO685_RS10240	COG1119	ATPase activity
IXO685_RS10250	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO685_RS10300	COG2937	Belongs to the GPAT DAPAT family
IXO685_RS10335	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO685_RS10340	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO685_RS10345	COG3132	Protein of unknown function, DUF480
IXO685_RS10360	COG0210	DNA helicase
IXO685_RS10375	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO685_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS10425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO685_RS10475	COG1166	arginine decarboxylase activity
IXO685_RS10480	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO685_RS10525	COG0606	chelatase, subunit chli
IXO685_RS10565	COG0366	Alpha amylase catalytic
IXO685_RS10570	COG0366	Alpha amylase catalytic
IXO685_RS10595	COG1609	Transcriptional regulator
IXO685_RS10640	COG0493	'glutamate synthase
IXO685_RS10645	COG0067	glutamate synthase
IXO685_RS10645	COG0070	glutamate synthase
IXO685_RS10645	COG0069	glutamate synthase activity
IXO685_RS10705	COG1111	helicase
IXO685_RS10705	COG1205	dead DEAH box helicase
IXO685_RS10710	COG1272	protein, Hemolysin III
IXO685_RS10750	COG1136	(ABC) transporter
IXO685_RS10800	COG1136	(ABC) transporter
IXO685_RS10840	COG3039	Transposase
IXO685_RS10845	COG0513	Belongs to the DEAD box helicase family
IXO685_RS10925	COG1858	cytochrome C peroxidase
IXO685_RS10940	COG0702	epimerase
IXO685_RS10965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO685_RS10985	COG1649	PFAM Uncharacterised BCR, COG1649
IXO685_RS10990	COG2354	Protein conserved in bacteria
IXO685_RS10995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO685_RS11010	COG1511	domain protein
IXO685_RS11010	COG3264	Mechanosensitive ion channel
IXO685_RS11090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO685_RS11200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO685_RS11220	COG1090	epimerase
IXO685_RS11230	COG3039	Transposase
IXO685_RS11255	COG2826	transposase and inactivated derivatives, IS30 family
IXO685_RS11350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_RS11365	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO685_RS11385	COG1304	FMN binding
IXO685_RS11390	COG3039	Transposase
IXO685_RS11405	COG4772	TonB-dependent receptor
IXO685_RS11415	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO685_RS11425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO685_RS11465	COG0501	Belongs to the peptidase M48B family
IXO685_RS11475	COG0187	DNA topoisomerase II activity
IXO685_RS11490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO685_RS11505	COG0706	membrane insertase activity
IXO685_RS11525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO685_RS11530	COG0671	phosphoesterase, PA-phosphatase related
IXO685_RS11540	COG0584	glycerophosphoryl diester phosphodiesterase
IXO685_RS11550	COG0861	Integral membrane protein TerC family
IXO685_RS11555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO685_RS11575	COG1929	Belongs to the glycerate kinase type-1 family
IXO685_RS11605	COG1192	Involved in chromosome partitioning
IXO685_RS11690	COG0477	Major facilitator Superfamily
IXO685_RS11710	COG0302	gtp cyclohydrolase
IXO685_RS11715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO685_RS11760	COG2234	aminopeptidase activity
IXO685_RS11770	COG4942	peptidase
IXO685_RS11775	COG0793	Belongs to the peptidase S41A family
IXO685_RS11825	COG0386	Belongs to the glutathione peroxidase family
IXO685_RS11835	COG1322	Protein conserved in bacteria
IXO685_RS11845	COG0531	amino acid
IXO685_RS11860	COG0210	DNA helicase
IXO685_RS11875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO685_RS11880	COG0583	DNA-binding transcription factor activity
IXO685_RS11885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO685_RS11895	COG2159	amidohydrolase
IXO685_RS11920	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO685_RS11925	COG3540	Alkaline phosphatase
IXO685_RS11935	COG2091	lysine biosynthetic process via aminoadipic acid
IXO685_RS11950	COG0708	Exodeoxyribonuclease III
IXO685_RS11965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO685_RS11970	COG3162	membrane
IXO685_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS12035	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO685_RS12040	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_RS12045	COG4807	Protein conserved in bacteria
IXO685_RS12050	COG1643	Atp-dependent helicase
IXO685_RS12060	COG1187	pseudouridine synthase activity
IXO685_RS12070	COG0667	Aldo Keto reductase
IXO685_RS12075	COG2130	NADP-dependent
IXO685_RS12080	COG0656	L-ascorbic acid biosynthetic process
IXO685_RS12120	COG3186	Phenylalanine-4-hydroxylase
IXO685_RS12125	COG1522	sequence-specific DNA binding
IXO685_RS12175	COG1064	alcohol dehydrogenase
IXO685_RS12180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_RS12190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_RS12200	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_RS12220	COG0676	glucose-6-phosphate 1-epimerase activity
IXO685_RS12285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO685_RS12310	COG2853	Lipoprotein
IXO685_RS12325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO685_RS12330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO685_RS12335	COG1127	ABC transporter
IXO685_RS12395	COG3039	Transposase
IXO685_RS12435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_RS12440	COG3265	gluconokinase activity
IXO685_RS12445	COG2211	Major facilitator Superfamily
IXO685_RS12450	COG3459	Glycosyltransferase 36 associated
IXO685_RS12460	COG2205	protein histidine kinase activity
IXO685_RS12475	COG1414	Transcriptional regulator
IXO685_RS12480	COG0738	Major facilitator superfamily
IXO685_RS12485	COG3254	rhamnose metabolic process
IXO685_RS12515	COG0339	signal peptide processing
IXO685_RS12540	COG0564	pseudouridine synthase activity
IXO685_RS12550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO685_RS12560	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO685_RS12660	COG0842	Transport permease protein
IXO685_RS12665	COG1131	(ABC) transporter
IXO685_RS12695	COG1476	TRANSCRIPTIONal
IXO685_RS12705	COG4555	ABC transporter
IXO685_RS12740	COG0625	glutathione transferase activity
IXO685_RS12785	COG0583	DNA-binding transcription factor activity
IXO685_RS12825	COG1199	ATP-dependent helicase activity
IXO685_RS12865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO685_RS12895	COG3228	Belongs to the MtfA family
IXO685_RS12905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO685_RS12905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO685_RS12910	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO685_RS12925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO685_RS12960	COG3237	CsbD-like
IXO685_RS12965	COG0180	Tryptophanyl-tRNA synthetase
IXO685_RS12970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO685_RS13020	COG0753	catalase activity
IXO685_RS13025	COG1595	DNA-templated transcription, initiation
IXO685_RS13035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO685_RS13045	COG0628	permease
IXO685_RS13055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO685_RS13060	COG1040	competence protein
IXO685_RS13065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO685_RS13070	COG0156	8-amino-7-oxononanoate synthase activity
IXO685_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS13095	COG0463	Glycosyl transferase, family 2
IXO685_RS13105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO685_RS13110	COG3100	YcgL domain-containing protein
IXO685_RS13125	COG3387	PFAM Glycoside hydrolase 15-related
IXO685_RS13130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO685_RS13145	COG2239	Acts as a magnesium transporter
IXO685_RS13155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO685_RS13155	COG1042	CoA-binding domain protein
IXO685_RS13155	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO685_RS13165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO685_RS13170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO685_RS13210	COG3485	protocatechuate 3,4-dioxygenase
IXO685_RS13215	COG3485	protocatechuate 3,4-dioxygenase
IXO685_RS13230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO685_RS13235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO685_RS13260	COG4221	oxidoreductase activity
IXO685_RS13285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO685_RS13310	COG0463	Glycosyl transferase, family 2
IXO685_RS13325	COG1475	DNA binding
IXO685_RS13330	COG1192	Involved in chromosome partitioning
IXO685_RS13345	COG0708	Exodeoxyribonuclease III
IXO685_RS13350	COG2211	Major facilitator Superfamily
IXO685_RS13365	COG0739	heme binding
IXO685_RS13410	COG0745	RESPONSE REGULATOR receiver
IXO685_RS13445	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO685_RS13460	COG2814	Major facilitator Superfamily
IXO685_RS13475	COG1289	transmembrane transporter activity
IXO685_RS13490	COG1136	(ABC) transporter
IXO685_RS13490	COG0577	efflux transmembrane transporter activity
IXO685_RS13495	COG0151	Belongs to the GarS family
IXO685_RS13505	COG0419	ATPase involved in DNA repair
IXO685_RS13550	COG2831	hemolysin activation secretion protein
IXO685_RS13555	COG3210	domain, Protein
IXO685_RS13585	COG3210	domain, Protein
IXO685_RS13635	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO685_RS13675	COG0439	Biotin carboxylase
IXO685_RS13685	COG0511	ligase activity, forming carbon-carbon bonds
IXO685_RS13690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO685_RS13700	COG1324	tolerance protein
IXO685_RS13740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO685_RS13760	COG0534	Mate efflux family protein
IXO685_RS13765	COG0616	signal peptide processing
IXO685_RS13775	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS13790	COG0009	L-threonylcarbamoyladenylate synthase
IXO685_RS13795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO685_RS13795	COG1754	DNA topoisomerase type I activity
IXO685_RS13810	COG2922	Belongs to the Smg family
IXO685_RS13815	COG0758	DNA mediated transformation
IXO685_RS13820	COG1652	LysM domain
IXO685_RS13825	COG0242	peptide deformylase activity
IXO685_RS13830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO685_RS13835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO685_RS13835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO685_RS13885	COG1560	Kdo2-lipid A biosynthetic process
IXO685_RS13895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO685_RS13950	COG3039	Transposase
IXO685_RS13995	COG0358	DNA primase activity
IXO685_RS14000	COG1295	ribonuclease BN
IXO685_RS14015	COG1610	YqeY-like protein
IXO685_RS14025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO685_RS14030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO685_RS14075	COG2133	pyrroloquinoline quinone binding
IXO685_RS14080	COG4682	membrane
IXO685_RS14105	COG0531	amino acid
IXO685_RS14130	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_RS14140	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO685_RS14145	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO685_RS14215	COG3039	Transposase
IXO685_RS14260	COG0183	Belongs to the thiolase family
IXO685_RS14305	COG3483	tryptophan 2,3-dioxygenase activity
IXO685_RS14310	COG3104	oligopeptide transport
IXO685_RS14330	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO685_RS14340	COG1320	monovalent cation:proton antiporter activity
IXO685_RS14345	COG2212	antiporter activity
IXO685_RS14355	COG0651	ATP synthesis coupled electron transport
IXO685_RS14360	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO685_RS14365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO685_RS14365	COG2111	Na H antiporter
IXO685_RS14410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO685_RS14420	COG0456	acetyltransferase
IXO685_RS14450	COG4221	oxidoreductase activity
IXO685_RS14510	COG0697	spore germination
IXO685_RS14515	COG4305	rare lipoprotein A
IXO685_RS14520	COG5297	Belongs to the glycosyl hydrolase family 6
IXO685_RS14530	COG1113	amino acid transport
IXO685_RS14540	COG0598	Magnesium transport protein CorA
IXO685_RS14560	COG3039	Transposase
IXO685_RS14620	COG5297	Belongs to the glycosyl hydrolase family 6
IXO685_RS14620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_RS14625	COG0659	secondary active sulfate transmembrane transporter activity
IXO685_RS14670	COG3275	phosphorelay sensor kinase activity
IXO685_RS14680	COG0181	hydroxymethylbilane synthase activity
IXO685_RS14705	COG1505	serine-type exopeptidase activity
IXO685_RS14720	COG0436	Aminotransferase
IXO685_RS14750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO685_RS14780	COG0308	aminopeptidase N
IXO685_RS14785	COG2199	diguanylate cyclase activity
IXO685_RS14835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_RS14840	COG1077	Cell shape determining protein MreB Mrl
IXO685_RS14845	COG1792	Involved in formation and maintenance of cell shape
IXO685_RS14860	COG0772	Belongs to the SEDS family
IXO685_RS14890	COG3039	Transposase
IXO685_RS14925	COG2951	lytic endotransglycosylase activity
IXO685_RS14930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO685_RS14935	COG1686	Belongs to the peptidase S11 family
IXO685_RS14945	COG2921	Belongs to the UPF0250 family
IXO685_RS14970	COG1051	belongs to the nudix hydrolase family
IXO685_RS14970	COG1056	cytidyltransferase-related domain
IXO685_RS15005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO685_RS15010	COG0673	inositol 2-dehydrogenase activity
IXO685_RS15015	COG2823	Periplasmic or secreted lipoprotein
IXO685_RS15020	COG4251	negative regulation of phosphorylation
IXO685_RS15025	COG0784	Response regulator, receiver
IXO685_RS15030	COG4191	Histidine kinase
IXO685_RS15035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO685_RS15085	COG3250	beta-galactosidase activity
IXO685_RS15100	COG2188	Transcriptional regulator
IXO685_RS15110	COG1609	Transcriptional regulator
IXO685_RS15115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO685_RS15120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO685_RS15130	COG1215	transferase activity, transferring glycosyl groups
IXO685_RS15135	COG0726	polysaccharide deacetylase
IXO685_RS15135	COG1649	PFAM Uncharacterised BCR, COG1649
IXO685_RS15235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO685_RS15240	COG3039	Transposase
IXO685_RS15285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO685_RS15335	COG2205	protein histidine kinase activity
IXO685_RS15365	COG3791	Glutathione-dependent formaldehyde-activating
IXO685_RS15390	COG0488	(ABC) transporter
IXO685_RS15410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO685_RS15430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO685_RS15430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO685_RS15450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO685_RS15455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO685_RS15460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO685_RS15480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO685_RS15485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO685_RS15495	COG2205	protein histidine kinase activity
IXO685_RS15500	COG0745	RESPONSE REGULATOR receiver
IXO685_RS15505	COG0277	FAD linked oxidase domain protein
IXO685_RS15510	COG1988	membrane-bound metal-dependent
IXO685_RS15515	COG0792	nuclease activity
IXO685_RS15550	COG0275	rRNA processing
IXO685_RS15555	COG3116	cell division
IXO685_RS15570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO685_RS15575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO685_RS15590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO685_RS15595	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO685_RS15600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO685_RS15615	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO685_RS15625	COG1388	LysM domain
IXO685_RS15625	COG4942	peptidase
IXO685_RS15630	COG0653	protein targeting
IXO685_RS15640	COG0494	nUDIX hydrolase
IXO685_RS15655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO685_RS15665	COG0604	alcohol dehydrogenase
IXO685_RS15665	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS15665	COG3321	synthase
IXO685_RS15710	COG2226	methyltransferase
IXO685_RS15715	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO685_RS15755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO685_RS15770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO685_RS15780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_RS15785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO685_RS15795	COG0667	Aldo Keto reductase
IXO685_RS15835	COG1116	anion transmembrane transporter activity
IXO685_RS15840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IXO685_RS15850	COG2175	clavaminate synthase activity
IXO685_RS15860	COG4181	ATPase activity
IXO685_RS15875	COG0642	Histidine kinase
IXO685_RS15895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO685_RS15915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO685_RS15935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IXO685_RS15940	COG2967	ApaG domain
IXO685_RS15945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO685_RS15955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO685_RS15970	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO685_RS15975	COG2096	Adenosyltransferase
IXO685_RS15985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO685_RS15990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO685_RS16030	COG0583	DNA-binding transcription factor activity
IXO685_RS16035	COG0318	PFAM AMP-dependent synthetase and ligase
IXO685_RS16045	COG1024	Enoyl-CoA hydratase
IXO685_RS16065	COG3386	PFAM SMP-30 Gluconolaconase
IXO685_RS16175	COG2197	response regulator
IXO685_RS16220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO685_RS16225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO685_RS16230	COG0583	DNA-binding transcription factor activity
IXO685_RS16235	COG3634	alkyl hydroperoxide reductase activity
IXO685_RS16245	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO685_RS16285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO685_RS16285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO685_RS16300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO685_RS16325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO685_RS16350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO685_RS16360	COG1404	Belongs to the peptidase S8 family
IXO685_RS16365	COG1404	Belongs to the peptidase S8 family
IXO685_RS16370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO685_RS16400	COG1295	ribonuclease BN
IXO685_RS16405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO685_RS16425	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO685_RS16435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO685_RS16440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO685_RS16450	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO685_RS16465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO685_RS16475	COG0193	aminoacyl-tRNA hydrolase activity
IXO685_RS16480	COG0012	GTP binding
IXO685_RS16510	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO685_RS16515	COG0250	Participates in transcription elongation, termination and antitermination
IXO685_RS16520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO685_RS16530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO685_RS16535	COG0222	ribosome binding
IXO685_RS16540	COG0085	RNA polymerase activity
IXO685_RS16545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO685_RS16550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO685_RS16555	COG0049	tRNA binding
IXO685_RS16575	COG0051	transcription antitermination factor activity, RNA binding
IXO685_RS16580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO685_RS16585	COG0088	Forms part of the polypeptide exit tunnel
IXO685_RS16590	COG0089	rRNA binding
IXO685_RS16605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO685_RS16615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO685_RS16620	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO685_RS16625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO685_RS16630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO685_RS16635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IXO685_RS16640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO685_RS16660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IXO685_RS16670	COG1841	ribosomal large subunit assembly
IXO685_RS16680	COG0201	protein transport
IXO685_RS16690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO685_RS16695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO685_RS16705	COG0203	ribosomal protein L17
IXO685_RS16765	COG3551	Protein conserved in bacteria
IXO685_RS16795	COG2194	sulfuric ester hydrolase activity
IXO685_RS16805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO685_RS16810	COG0745	RESPONSE REGULATOR receiver
IXO685_RS16815	COG0642	Histidine kinase
IXO685_RS16825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO685_RS16830	COG2894	cell division
IXO685_RS16850	COG4585	Histidine kinase
IXO685_RS16855	COG2197	response regulator
IXO685_RS16870	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO685_RS17015	COG3039	Transposase
IXO685_RS17075	COG1741	Belongs to the pirin family
IXO685_RS17085	COG1515	deoxyribonuclease V activity
IXO685_RS17090	COG0588	phosphoglycerate mutase activity
IXO685_RS17105	COG3590	peptidase
IXO685_RS17120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO685_RS17125	COG2200	EAL domain
IXO685_RS17125	COG2202	Pas domain
IXO685_RS17125	COG2199	diguanylate cyclase activity
IXO685_RS17130	COG0835	chemotaxis
IXO685_RS17135	COG0840	transmembrane signaling receptor activity
IXO685_RS17140	COG0643	Histidine kinase
IXO685_RS17140	COG2198	Histidine kinase
IXO685_RS17155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO685_RS17165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO685_RS17205	COG3039	Transposase
IXO685_RS17255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO685_RS17260	COG0735	belongs to the Fur family
IXO685_RS17320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO685_RS17325	COG0084	hydrolase, TatD family'
IXO685_RS17340	COG1960	acyl-CoA dehydrogenase activity
IXO685_RS17355	COG0367	asparagine synthase
IXO685_RS17365	COG0305	Participates in initiation and elongation during chromosome replication
IXO685_RS17370	COG0415	Belongs to the DNA photolyase family
IXO685_RS17495	COG5001	Diguanylate cyclase
IXO685_RS17495	COG5002	protein histidine kinase activity
IXO685_RS17500	COG1187	pseudouridine synthase activity
IXO685_RS17520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO685_RS17530	COG0475	glutathione-regulated potassium exporter activity
IXO685_RS17535	COG5002	protein histidine kinase activity
IXO685_RS17535	COG5000	phosphorelay sensor kinase activity
IXO685_RS17540	COG0745	RESPONSE REGULATOR receiver
IXO685_RS17570	COG1132	(ABC) transporter
IXO685_RS17620	COG3039	Transposase
IXO685_RS17635	COG3209	COG3209 Rhs family protein
IXO685_RS17650	COG3039	Transposase
IXO685_RS17685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO685_RS17695	COG4969	Belongs to the N-Me-Phe pilin family
IXO685_RS17700	COG2194	sulfuric ester hydrolase activity
IXO685_RS17720	COG2184	nucleotidyltransferase activity
IXO685_RS17745	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO685_RS17750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO685_RS17760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO685_RS17760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO685_RS17765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_RS17770	COG0564	pseudouridine synthase activity
IXO685_RS17795	COG3387	PFAM Glycoside hydrolase 15-related
IXO685_RS17800	COG1877	trehalose-phosphatase activity
IXO685_RS17840	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO685_RS17865	COG1946	Acyl-CoA thioesterase
IXO685_RS17880	COG0824	Thioesterase
IXO685_RS17885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO685_RS17895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO685_RS17900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO685_RS17905	COG0268	Binds directly to 16S ribosomal RNA
IXO685_RS17910	COG0728	peptidoglycan biosynthetic process
IXO685_RS17915	COG0196	riboflavin kinase activity
IXO685_RS17925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO685_RS17930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO685_RS17945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO685_RS17950	COG1845	cytochrome c oxidase, subunit III
IXO685_RS17955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO685_RS17980	COG3209	COG3209 Rhs family protein
IXO685_RS17995	COG3039	Transposase
IXO685_RS18030	COG3039	Transposase
IXO685_RS18035	COG3209	COG3209 Rhs family protein
IXO685_RS18060	COG3039	Transposase
IXO685_RS18085	COG3039	Transposase
IXO685_RS18145	COG3118	belongs to the thioredoxin family
IXO685_RS18170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO685_RS18195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO685_RS18225	COG2968	Membrane
IXO685_RS18240	COG3164	Protein of unknown function
IXO685_RS18250	COG0312	modulator of DNA gyrase
IXO685_RS18255	COG3028	Belongs to the UPF0307 family
IXO685_RS18260	COG0312	modulator of DNA gyrase
IXO685_RS18285	COG0142	geranyltranstransferase activity
IXO685_RS18290	COG1722	exodeoxyribonuclease VII activity
IXO685_RS18295	COG0037	tRNA processing
IXO685_RS18300	COG1785	Belongs to the alkaline phosphatase family
IXO685_RS18315	COG3039	Transposase
IXO685_RS18330	COG0791	NLP P60 protein
IXO685_RS18335	COG0791	NLP P60 protein
IXO685_RS18340	COG1047	Peptidyl-prolyl cis-trans
IXO685_RS18345	COG2311	Membrane
IXO685_RS18350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_RS18390	COG0489	protein tyrosine kinase activity
IXO685_RS18395	COG0717	Belongs to the dCTP deaminase family
IXO685_RS18425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO685_RS18455	COG3179	chitinase
IXO685_RS18620	COG0732	type I restriction modification DNA specificity domain
IXO685_RS18635	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO685_RS18655	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO685_RS18660	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO685_RS18665	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO685_RS18680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO685_RS18755	COG0587	DNA-directed DNA polymerase activity
IXO685_RS18770	COG1297	OPT oligopeptide transporter protein
IXO685_RS18790	COG0823	Involved in the tonB-independent uptake of proteins
IXO685_RS18790	COG1506	peptidase
IXO685_RS18810	COG1917	Cupin 2, conserved barrel domain protein
IXO685_RS18810	COG2207	Transcriptional regulator
IXO685_RS18835	COG0753	catalase activity
IXO685_RS18865	COG0126	phosphoglycerate kinase activity
IXO685_RS18875	COG0469	pyruvate kinase activity
IXO685_RS18880	COG3588	fructose-bisphosphate aldolase
IXO685_RS18885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO685_RS18935	COG2198	Histidine kinase
IXO685_RS18935	COG2205	protein histidine kinase activity
IXO685_RS18935	COG0784	Response regulator, receiver
IXO685_RS18955	COG0175	sulfate reduction
IXO685_RS18960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO685_RS18965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO685_RS18970	COG0175	sulfate reduction
IXO685_RS18975	COG0529	Catalyzes the synthesis of activated sulfate
IXO685_RS18975	COG2895	sulfate adenylyltransferase (ATP) activity
IXO685_RS18985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO685_RS18990	COG0308	aminopeptidase N
IXO685_RS19010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO685_RS19015	COG2272	Belongs to the type-B carboxylesterase lipase family
IXO685_RS19045	COG1970	mechanosensitive ion channel activity
IXO685_RS19075	COG0471	metal ion transport
IXO685_RS19075	COG3273	potassium ion transport
IXO685_RS19085	COG2022	thiamine diphosphate biosynthetic process
IXO685_RS19265	COG0632	four-way junction helicase activity
IXO685_RS19275	COG2255	four-way junction helicase activity
IXO685_RS19280	COG0824	Thioesterase
IXO685_RS19290	COG0848	biopolymer transport protein
IXO685_RS19300	COG0823	Involved in the tonB-independent uptake of proteins
IXO685_RS19305	COG2885	chlorophyll binding
IXO685_RS19315	COG0602	queuosine metabolic process
IXO685_RS19340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO685_RS19365	COG0514	ATP-dependent DNA helicase (RecQ)
IXO685_RS19370	COG0783	Belongs to the Dps family
IXO685_RS19375	COG1643	Atp-dependent helicase
IXO685_RS19410	COG0535	radical SAM domain protein
IXO685_RS19415	COG0535	radical SAM domain protein
IXO685_RS19420	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IXO685_RS19435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO685_RS19445	COG1215	transferase activity, transferring glycosyl groups
IXO685_RS19450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO685_RS19460	COG1199	ATP-dependent helicase activity
IXO685_RS19470	COG1397	ADP-ribosylglycohydrolase
IXO685_RS19480	COG0189	ligase activity
IXO685_RS19495	COG0835	chemotaxis
IXO685_RS19500	COG0840	transmembrane signaling receptor activity
IXO685_RS19505	COG0643	Histidine kinase
IXO685_RS19505	COG0784	Response regulator, receiver
IXO685_RS19505	COG2198	Histidine kinase
IXO685_RS19535	COG2304	oxidoreductase activity
IXO685_RS19540	COG2304	oxidoreductase activity
IXO685_RS19550	COG1446	asparaginase
IXO685_RS19595	COG3537	Alpha-1,2-mannosidase
IXO685_RS19665	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO685_RS19675	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO685_RS19685	COG3858	chitin binding
IXO685_RS19685	COG1388	LysM domain
IXO685_RS19700	COG0837	glucose binding
IXO685_RS19705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO685_RS19715	COG0494	nUDIX hydrolase
IXO685_RS19725	COG3956	TIGRFAM MazG family protein
IXO685_RS19740	COG0330	HflC and HflK could
IXO685_RS19755	COG0509	glycine decarboxylation via glycine cleavage system
IXO685_RS19790	COG1960	acyl-CoA dehydrogenase activity
IXO685_RS19800	COG1309	transcriptional regulator
IXO685_RS19805	COG4771	TonB-dependent receptor
IXO685_RS19815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO685_RS19825	COG0463	Glycosyl transferase, family 2
IXO685_RS19850	COG1272	protein, Hemolysin III
IXO685_RS19855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IXO685_RS19860	COG0739	heme binding
IXO685_RS19865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO685_RS19870	COG0626	cystathionine gamma-synthase activity
IXO685_RS19880	COG1760	l-serine dehydratase
IXO685_RS19895	COG2353	YceI-like domain
IXO685_RS19905	COG2353	YceI-like domain
IXO685_RS19975	COG1960	acyl-CoA dehydrogenase activity
IXO685_RS19980	COG1024	Enoyl-CoA hydratase
IXO685_RS20000	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO685_RS20000	COG1024	Enoyl-CoA hydratase
IXO685_RS20015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO685_RS20045	COG1381	Involved in DNA repair and RecF pathway recombination
IXO685_RS20060	COG2954	triphosphatase activity
IXO685_RS20085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO685_RS20090	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO685_RS20095	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO685_RS20105	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO685_RS20110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO685_RS20115	COG1278	Cold shock
IXO685_RS20140	COG1201	RNA secondary structure unwinding
IXO685_RS20145	COG1793	dna ligase
IXO685_RS20155	COG1793	dna ligase
IXO685_RS20155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO685_RS20185	COG0183	Belongs to the thiolase family
IXO685_RS20220	COG3039	Transposase
IXO685_RS20225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO685_RS20230	COG3039	Transposase
IXO685_RS20280	COG1047	Peptidyl-prolyl cis-trans
IXO685_RS20295	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO685_RS20305	COG1902	pentaerythritol trinitrate reductase activity
IXO685_RS20310	COG2814	Major facilitator Superfamily
IXO685_RS20345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO685_RS20345	COG0392	lysyltransferase activity
IXO685_RS20355	COG0251	oxidation-reduction process
IXO685_RS20360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO685_RS20375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO685_RS20400	COG1595	DNA-templated transcription, initiation
IXO685_RS20415	COG2878	Part of a membrane complex involved in electron transport
IXO685_RS20425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO685_RS20425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO685_RS20445	COG0833	amino acid
IXO685_RS20450	COG2040	homocysteine
IXO685_RS20465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO685_RS20500	COG0529	Catalyzes the synthesis of activated sulfate
IXO685_RS20500	COG2895	sulfate adenylyltransferase (ATP) activity
IXO685_RS20545	COG1981	membrane
IXO685_RS20570	COG1131	(ABC) transporter
IXO685_RS20575	COG4771	TonB-dependent receptor
IXO685_RS20585	COG0825	malonyl-CoA metabolic process
IXO685_RS20605	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO685_RS20610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO685_RS20635	COG0750	zinc metalloprotease
IXO685_RS20645	COG0575	Belongs to the CDS family
IXO685_RS20655	COG0233	cytoplasmic translational termination
IXO685_RS20670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO685_RS20730	COG1393	Belongs to the ArsC family
IXO685_RS20745	COG0367	asparagine synthase
IXO685_RS20755	COG4774	siderophore transport
IXO685_RS20780	COG2207	Transcriptional regulator
IXO685_RS20795	COG1566	PFAM secretion protein HlyD family protein
IXO685_RS20800	COG2814	Major facilitator Superfamily
IXO685_RS20845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO685_RS20855	COG1960	acyl-CoA dehydrogenase activity
IXO685_RS20870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO685_RS20880	COG2914	Belongs to the UPF0125 (RnfH) family
IXO685_RS20885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_RS20895	COG0497	DNA recombination
IXO685_RS20905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO685_RS20915	COG0484	heat shock protein binding
IXO685_RS20920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO685_RS20925	COG1605	Chorismate mutase
IXO685_RS20925	COG0287	Prephenate dehydrogenase
IXO685_RS20950	COG1132	(ABC) transporter
IXO685_RS20985	COG2850	peptidyl-arginine hydroxylation
IXO685_RS21060	COG1131	(ABC) transporter
IXO685_RS21065	COG1725	Transcriptional regulator
IXO685_RS21075	COG0386	Belongs to the glutathione peroxidase family
IXO685_RS21090	COG2900	Belongs to the SlyX family
IXO685_RS21105	COG1609	Transcriptional regulator
IXO685_RS21115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_RS21125	COG0646	methionine synthase
IXO685_RS21125	COG1410	methionine synthase
IXO685_RS21130	COG1410	methionine synthase
IXO685_RS21130	COG0646	methionine synthase
IXO685_RS21135	COG2226	methyltransferase
IXO685_RS21140	COG1960	acyl-CoA dehydrogenase activity
IXO685_RS21165	COG0557	exoribonuclease II activity
IXO685_RS21180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO685_RS21190	COG3039	Transposase
IXO685_RS21315	COG3039	Transposase
IXO685_RS21325	COG0583	DNA-binding transcription factor activity
IXO685_RS21400	COG0742	ribosomal rna small subunit methyltransferase
IXO685_RS21405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO685_RS21415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO685_RS21420	COG0405	Gamma-glutamyltransferase
IXO685_RS21490	COG3501	Rhs element vgr protein
IXO685_RS21490	COG3409	Peptidoglycan-binding domain 1 protein
IXO685_RS21575	COG3039	Transposase
IXO685_RS21585	COG3039	Transposase
IXO685_RS21600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO685_RS21600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO685_RS21605	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO685_RS21610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO685_RS21610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO685_RS21615	COG1609	Transcriptional regulator
IXO685_RS21635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO685_RS21640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_RS21650	COG2902	Dehydrogenase
IXO685_RS21655	COG3039	Transposase
IXO685_RS21665	COG5002	protein histidine kinase activity
IXO685_RS21665	COG2205	protein histidine kinase activity
IXO685_RS21665	COG0784	Response regulator, receiver
IXO685_RS21670	COG2733	membrane
IXO685_RS21680	COG1121	(ABC) transporter
IXO685_RS21685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO685_RS21690	COG2223	nitrite transmembrane transporter activity
IXO685_RS21700	COG0243	molybdopterin cofactor binding
IXO685_RS21710	COG0477	Major facilitator Superfamily
IXO685_RS21720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_RS21725	COG0174	glutamine synthetase
IXO685_RS21760	COG3842	ATPase activity
IXO685_RS21780	COG1012	belongs to the aldehyde dehydrogenase family
IXO685_RS21795	COG4535	Mg2 and Co2 transporter CorC
IXO685_RS21815	COG1702	phosphate starvation-inducible protein PhoH
IXO685_RS21840	COG0741	lytic transglycosylase activity
IXO685_RS21845	COG0723	plastoquinol--plastocyanin reductase activity
IXO685_RS21850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO685_RS21855	COG2857	Cytochrome c1
IXO685_RS21860	COG0625	glutathione transferase activity
IXO685_RS21865	COG2969	positive regulation of protein catabolic process
IXO685_RS21890	COG2094	Belongs to the DNA glycosylase MPG family
IXO685_RS21900	COG3328	transposase activity
IXO685_RS21980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO685_RS21995	COG1570	exodeoxyribonuclease VII activity
IXO685_RS22000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO685_RS22005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO685_RS22005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO685_RS22010	COG0802	atpase or kinase
IXO685_RS22015	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO685_RS22020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO685_RS22040	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS22050	COG0501	Belongs to the peptidase M48B family
IXO685_RS22060	COG2081	HI0933 family
IXO685_RS22065	COG4681	YaeQ
IXO685_RS22070	COG1671	Belongs to the UPF0178 family
IXO685_RS22080	COG0625	glutathione transferase activity
IXO685_RS22095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO685_RS22100	COG0513	Belongs to the DEAD box helicase family
IXO685_RS22105	COG0488	(ABC) transporter
IXO685_RS22125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO685_RS22130	COG0483	inositol monophosphate 1-phosphatase activity
IXO685_RS22145	COG5001	Diguanylate cyclase
IXO685_RS22145	COG3300	MHYT domain
IXO685_RS22150	COG1509	lysine 2,3-aminomutase activity
IXO685_RS22165	COG0402	S-adenosylhomocysteine deaminase activity
IXO685_RS22170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO685_RS22195	COG4677	pectinesterase activity
IXO685_RS22215	COG3039	Transposase
IXO685_RS22245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO685_RS22275	COG2166	iron-sulfur cluster assembly
IXO685_RS22290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO685_RS22295	COG0137	argininosuccinate synthase activity
IXO685_RS22305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO685_RS22310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO685_RS22325	COG0165	Argininosuccinate lyase
IXO685_RS22345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO685_RS22390	COG4988	ABC transporter
IXO685_RS22395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO685_RS22480	COG1858	cytochrome C peroxidase
IXO685_RS22500	COG3209	COG3209 Rhs family protein
IXO685_RS22510	COG3039	Transposase
IXO685_RS22535	COG0643	Histidine kinase
IXO685_RS22535	COG0784	Response regulator, receiver
IXO685_RS22535	COG2198	Histidine kinase
IXO685_RS22590	COG1684	flagellar biosynthetic protein fliR
IXO685_RS22605	COG3190	flagellar
IXO685_RS22655	COG1677	Flagellar hook-basal body complex protein FliE
IXO685_RS22685	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS22695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO685_RS22715	COG2201	protein-glutamate methylesterase activity
IXO685_RS22745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO685_RS22750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO685_RS22785	COG4787	bacterial-type flagellum-dependent cell motility
IXO685_RS22795	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO685_RS22800	COG1558	bacterial-type flagellum-dependent cell motility
IXO685_RS22810	COG0835	chemotaxis
IXO685_RS22810	COG0784	Response regulator, receiver
IXO685_RS22830	COG5002	protein histidine kinase activity
IXO685_RS22840	COG4585	Histidine kinase
IXO685_RS22845	COG5001	Diguanylate cyclase
IXO685_RS22870	COG0482	sulfurtransferase activity
IXO685_RS22885	COG0542	response to heat
IXO685_RS22920	COG0492	ferredoxin-NADP+ reductase activity
IXO685_RS22925	COG1674	ftsk spoiiie
IXO685_RS22945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO685_RS22965	COG0038	chloride channel
IXO685_RS22975	COG0183	Belongs to the thiolase family
IXO685_RS22980	COG1024	Enoyl-CoA hydratase
IXO685_RS22980	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO685_RS22995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO685_RS23015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_RS23025	COG0303	'Molybdopterin
IXO685_RS23095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO685_RS23105	COG3039	Transposase
IXO685_RS23135	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO685_RS23145	COG0531	amino acid
IXO685_RS23150	COG0531	amino acid
IXO685_RS23160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO685_RS23165	COG0277	FAD linked oxidase domain protein
IXO685_RS23225	COG4133	protoheme IX ABC transporter activity
IXO685_RS23230	COG0436	Aminotransferase
IXO685_RS23255	COG1187	pseudouridine synthase activity
IXO685_RS23260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO685_RS23265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO685_RS23270	COG2350	Protein conserved in bacteria
IXO685_RS23300	COG1175	transmembrane transport
IXO685_RS23305	COG0395	ABC-type sugar transport system, permease component
IXO685_RS23330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO685_RS23340	COG2957	Belongs to the agmatine deiminase family
IXO685_RS23355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO685_RS23360	COG0539	negative regulation of cytoplasmic translation
IXO685_RS23365	COG0776	regulation of translation
IXO685_RS23375	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO685_RS23380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO685_RS23390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO685_RS23420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO685_RS23435	COG3002	Belongs to the UPF0753 family
IXO685_RS23440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO685_RS23445	COG0583	DNA-binding transcription factor activity
IXO685_RS23460	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS23495	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO685_RS23515	COG0668	transmembrane transport
IXO685_RS23540	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_RS23545	COG1183	phosphatidylcholine synthase activity
IXO685_RS23555	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO685_RS23570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_RS23570	COG0723	plastoquinol--plastocyanin reductase activity
IXO685_RS23580	COG2183	response to ionizing radiation
IXO685_RS23595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO685_RS23610	COG0671	phosphoesterase, PA-phosphatase related
IXO685_RS23635	COG0697	spore germination
IXO685_RS23665	COG1012	belongs to the aldehyde dehydrogenase family
IXO685_RS23710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO685_RS23725	COG0124	histidyl-tRNA synthetase
IXO685_RS23755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO685_RS23770	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO685_RS23770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO685_RS23780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO685_RS23790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO685_RS23790	COG0140	phosphoribosyl-ATP diphosphatase activity