locus-tag	class	description
IXO704_RS00015	COG1192	Involved in chromosome partitioning
IXO704_RS00020	COG1475	DNA binding
IXO704_RS00050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IXO704_RS00065	COG0741	lytic transglycosylase activity
IXO704_RS00080	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IXO704_RS00085	COG2948	multi-organism process
IXO704_RS00100	COG3704	protein secretion by the type IV secretion system
IXO704_RS00115	COG3451	type IV secretory pathway VirB4
IXO704_RS00150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO704_RS00165	COG0187	DNA topoisomerase II activity
IXO704_RS00175	COG0501	Belongs to the peptidase M48B family
IXO704_RS00205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO704_RS00215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO704_RS00225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO704_RS00235	COG4772	TonB-dependent receptor
IXO704_RS00255	COG1304	FMN binding
IXO704_RS00285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO704_RS00370	COG2826	transposase and inactivated derivatives, IS30 family
IXO704_RS00395	COG3039	Transposase
IXO704_RS00405	COG1090	epimerase
IXO704_RS00415	COG0642	Histidine kinase
IXO704_RS00425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO704_RS00535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO704_RS00610	COG3264	Mechanosensitive ion channel
IXO704_RS00610	COG1511	domain protein
IXO704_RS00625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO704_RS00630	COG2354	Protein conserved in bacteria
IXO704_RS00655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO704_RS00680	COG0702	epimerase
IXO704_RS00695	COG1858	cytochrome C peroxidase
IXO704_RS00770	COG0513	Belongs to the DEAD box helicase family
IXO704_RS00775	COG3039	Transposase
IXO704_RS00820	COG1136	(ABC) transporter
IXO704_RS00850	COG1136	(ABC) transporter
IXO704_RS00890	COG1272	protein, Hemolysin III
IXO704_RS00895	COG1111	helicase
IXO704_RS00895	COG1205	dead DEAH box helicase
IXO704_RS00955	COG0069	glutamate synthase activity
IXO704_RS00955	COG0070	glutamate synthase
IXO704_RS00955	COG0067	glutamate synthase
IXO704_RS00960	COG0493	'glutamate synthase
IXO704_RS01000	COG1609	Transcriptional regulator
IXO704_RS01025	COG0366	Alpha amylase catalytic
IXO704_RS01030	COG0366	Alpha amylase catalytic
IXO704_RS01070	COG0606	chelatase, subunit chli
IXO704_RS01110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO704_RS01115	COG1166	arginine decarboxylase activity
IXO704_RS01130	COG3501	Rhs element vgr protein
IXO704_RS01220	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS01245	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO704_RS01260	COG0210	DNA helicase
IXO704_RS01275	COG3132	Protein of unknown function, DUF480
IXO704_RS01280	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO704_RS01285	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO704_RS01325	COG0604	alcohol dehydrogenase
IXO704_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS01325	COG3321	synthase
IXO704_RS01360	COG3186	Phenylalanine-4-hydroxylase
IXO704_RS01365	COG1522	sequence-specific DNA binding
IXO704_RS01410	COG1064	alcohol dehydrogenase
IXO704_RS01415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO704_RS01420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO704_RS01430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO704_RS01450	COG0676	glucose-6-phosphate 1-epimerase activity
IXO704_RS01515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO704_RS01535	COG2853	Lipoprotein
IXO704_RS01550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO704_RS01555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO704_RS01560	COG1127	ABC transporter
IXO704_RS01635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO704_RS01640	COG3265	gluconokinase activity
IXO704_RS01645	COG2211	Major facilitator Superfamily
IXO704_RS01650	COG3459	Glycosyltransferase 36 associated
IXO704_RS01660	COG2205	protein histidine kinase activity
IXO704_RS01670	COG1414	Transcriptional regulator
IXO704_RS01675	COG0738	Major facilitator superfamily
IXO704_RS01680	COG3254	rhamnose metabolic process
IXO704_RS01710	COG0339	signal peptide processing
IXO704_RS01740	COG0564	pseudouridine synthase activity
IXO704_RS01750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO704_RS01760	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO704_RS01805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO704_RS01815	COG0842	Transport permease protein
IXO704_RS01820	COG1131	(ABC) transporter
IXO704_RS01850	COG1476	TRANSCRIPTIONal
IXO704_RS01860	COG4555	ABC transporter
IXO704_RS01895	COG0625	glutathione transferase activity
IXO704_RS01940	COG0583	DNA-binding transcription factor activity
IXO704_RS01980	COG1199	ATP-dependent helicase activity
IXO704_RS02000	COG1566	PFAM secretion protein HlyD family protein
IXO704_RS02025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO704_RS02035	COG0745	RESPONSE REGULATOR receiver
IXO704_RS02040	COG2205	protein histidine kinase activity
IXO704_RS02065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO704_RS02065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO704_RS02070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO704_RS02085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO704_RS02120	COG3237	CsbD-like
IXO704_RS02125	COG0180	Tryptophanyl-tRNA synthetase
IXO704_RS02130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO704_RS02175	COG0753	catalase activity
IXO704_RS02180	COG1595	DNA-templated transcription, initiation
IXO704_RS02190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO704_RS02200	COG0628	permease
IXO704_RS02210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO704_RS02215	COG1040	competence protein
IXO704_RS02220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO704_RS02225	COG0156	8-amino-7-oxononanoate synthase activity
IXO704_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS02250	COG0463	Glycosyl transferase, family 2
IXO704_RS02260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO704_RS02265	COG3100	YcgL domain-containing protein
IXO704_RS02280	COG3387	PFAM Glycoside hydrolase 15-related
IXO704_RS02285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO704_RS02290	COG3039	Transposase
IXO704_RS02355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO704_RS02370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO704_RS02375	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO704_RS02385	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO704_RS02390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO704_RS02395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO704_RS02445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO704_RS02460	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO704_RS02525	COG0358	DNA primase activity
IXO704_RS02530	COG1295	ribonuclease BN
IXO704_RS02540	COG1610	YqeY-like protein
IXO704_RS02550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO704_RS02555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO704_RS02595	COG2133	pyrroloquinoline quinone binding
IXO704_RS02600	COG4682	membrane
IXO704_RS02625	COG0531	amino acid
IXO704_RS02650	COG4948	Mandelate Racemase Muconate Lactonizing
IXO704_RS02660	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO704_RS02665	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO704_RS02735	COG0183	Belongs to the thiolase family
IXO704_RS02775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO704_RS02785	COG3483	tryptophan 2,3-dioxygenase activity
IXO704_RS02790	COG3104	oligopeptide transport
IXO704_RS02820	COG1320	monovalent cation:proton antiporter activity
IXO704_RS02825	COG2212	antiporter activity
IXO704_RS02835	COG0651	ATP synthesis coupled electron transport
IXO704_RS02840	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO704_RS02845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO704_RS02845	COG2111	Na H antiporter
IXO704_RS02895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO704_RS02905	COG0456	acetyltransferase
IXO704_RS02925	COG2801	Transposase and inactivated derivatives
IXO704_RS02935	COG4221	oxidoreductase activity
IXO704_RS02975	COG3039	Transposase
IXO704_RS02995	COG0697	spore germination
IXO704_RS03000	COG4305	rare lipoprotein A
IXO704_RS03005	COG5297	Belongs to the glycosyl hydrolase family 6
IXO704_RS03015	COG1113	amino acid transport
IXO704_RS03025	COG0598	Magnesium transport protein CorA
IXO704_RS03095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO704_RS03095	COG5297	Belongs to the glycosyl hydrolase family 6
IXO704_RS03100	COG0659	secondary active sulfate transmembrane transporter activity
IXO704_RS03135	COG3275	phosphorelay sensor kinase activity
IXO704_RS03145	COG0181	hydroxymethylbilane synthase activity
IXO704_RS03170	COG1505	serine-type exopeptidase activity
IXO704_RS03185	COG3039	Transposase
IXO704_RS03220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO704_RS03250	COG0308	aminopeptidase N
IXO704_RS03255	COG2199	diguanylate cyclase activity
IXO704_RS03305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO704_RS03310	COG1077	Cell shape determining protein MreB Mrl
IXO704_RS03315	COG1792	Involved in formation and maintenance of cell shape
IXO704_RS03330	COG0772	Belongs to the SEDS family
IXO704_RS03340	COG3501	Rhs element vgr protein
IXO704_RS03365	COG2951	lytic endotransglycosylase activity
IXO704_RS03370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO704_RS03375	COG1686	Belongs to the peptidase S11 family
IXO704_RS03390	COG2921	Belongs to the UPF0250 family
IXO704_RS03415	COG1051	belongs to the nudix hydrolase family
IXO704_RS03415	COG1056	cytidyltransferase-related domain
IXO704_RS03450	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO704_RS03455	COG0673	inositol 2-dehydrogenase activity
IXO704_RS03460	COG2823	Periplasmic or secreted lipoprotein
IXO704_RS03465	COG4251	negative regulation of phosphorylation
IXO704_RS03470	COG0784	Response regulator, receiver
IXO704_RS03475	COG4191	Histidine kinase
IXO704_RS03480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO704_RS03530	COG3250	beta-galactosidase activity
IXO704_RS03545	COG2188	Transcriptional regulator
IXO704_RS03555	COG1609	Transcriptional regulator
IXO704_RS03560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO704_RS03565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO704_RS03575	COG1215	transferase activity, transferring glycosyl groups
IXO704_RS03580	COG1649	PFAM Uncharacterised BCR, COG1649
IXO704_RS03580	COG0726	polysaccharide deacetylase
IXO704_RS03660	COG3039	Transposase
IXO704_RS03665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO704_RS03670	COG3039	Transposase
IXO704_RS03705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO704_RS03720	COG2205	protein histidine kinase activity
IXO704_RS03755	COG2205	protein histidine kinase activity
IXO704_RS03760	COG0745	RESPONSE REGULATOR receiver
IXO704_RS03795	COG3039	Transposase
IXO704_RS03810	COG0488	(ABC) transporter
IXO704_RS03830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO704_RS03850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO704_RS03850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO704_RS03870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO704_RS03875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO704_RS03880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO704_RS03900	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO704_RS03905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO704_RS03915	COG2205	protein histidine kinase activity
IXO704_RS03920	COG0745	RESPONSE REGULATOR receiver
IXO704_RS03925	COG0277	FAD linked oxidase domain protein
IXO704_RS03930	COG1988	membrane-bound metal-dependent
IXO704_RS03935	COG0792	nuclease activity
IXO704_RS03970	COG0275	rRNA processing
IXO704_RS03975	COG3116	cell division
IXO704_RS03990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO704_RS03995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO704_RS04010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO704_RS04015	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO704_RS04020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO704_RS04035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO704_RS04045	COG1388	LysM domain
IXO704_RS04045	COG4942	peptidase
IXO704_RS04050	COG0653	protein targeting
IXO704_RS04060	COG0494	nUDIX hydrolase
IXO704_RS04075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO704_RS04085	COG0604	alcohol dehydrogenase
IXO704_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS04085	COG3321	synthase
IXO704_RS04135	COG2226	methyltransferase
IXO704_RS04140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO704_RS04175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO704_RS04180	COG3039	Transposase
IXO704_RS04195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO704_RS04205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO704_RS04210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO704_RS04220	COG3039	Transposase
IXO704_RS04240	COG0667	Aldo Keto reductase
IXO704_RS04295	COG2175	clavaminate synthase activity
IXO704_RS04305	COG4181	ATPase activity
IXO704_RS04320	COG0642	Histidine kinase
IXO704_RS04345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO704_RS04365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO704_RS04390	COG2967	ApaG domain
IXO704_RS04395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO704_RS04405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO704_RS04420	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO704_RS04425	COG2096	Adenosyltransferase
IXO704_RS04435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO704_RS04440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO704_RS04480	COG0583	DNA-binding transcription factor activity
IXO704_RS04485	COG0318	PFAM AMP-dependent synthetase and ligase
IXO704_RS04495	COG1024	Enoyl-CoA hydratase
IXO704_RS04515	COG3386	PFAM SMP-30 Gluconolaconase
IXO704_RS04630	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO704_RS04630	COG1902	pentaerythritol trinitrate reductase activity
IXO704_RS04635	COG0604	alcohol dehydrogenase
IXO704_RS04660	COG0156	8-amino-7-oxononanoate synthase activity
IXO704_RS04665	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO704_RS04670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO704_RS04675	COG4208	sulfate ABC transporter
IXO704_RS04680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO704_RS04710	COG0588	phosphoglycerate mutase activity
IXO704_RS04720	COG0285	dihydrofolate synthase activity
IXO704_RS04740	COG2833	Protein of unknown function (DUF455)
IXO704_RS04760	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO704_RS04765	COG0671	phosphoesterase, PA-phosphatase related
IXO704_RS04770	COG0438	transferase activity, transferring glycosyl groups
IXO704_RS04780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO704_RS04795	COG4783	chaperone-mediated protein folding
IXO704_RS04820	COG0473	3-isopropylmalate dehydrogenase activity
IXO704_RS04870	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO704_RS04910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO704_RS04940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO704_RS04950	COG0631	protein serine/threonine phosphatase activity
IXO704_RS04975	COG3501	Rhs element vgr protein
IXO704_RS05020	COG0582	viral genome integration into host DNA
IXO704_RS05030	COG0859	PFAM glycosyl transferase family 9
IXO704_RS05035	COG3642	lipopolysaccharide core region biosynthetic process
IXO704_RS05040	COG1234	tRNA 3'-trailer cleavage
IXO704_RS05045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO704_RS05055	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO704_RS05060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO704_RS05065	COG0314	molybdopterin synthase activity
IXO704_RS05095	COG0537	adenosine 5'-monophosphoramidase activity
IXO704_RS05115	COG0714	Associated with various cellular activities
IXO704_RS05135	COG0242	peptide deformylase activity
IXO704_RS05220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO704_RS05250	COG1162	GTPase activity
IXO704_RS05275	COG2211	Major facilitator Superfamily
IXO704_RS05285	COG1609	Transcriptional regulator
IXO704_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS05295	COG2851	Citrate transporter
IXO704_RS05320	COG2197	response regulator
IXO704_RS05335	COG0583	DNA-binding transcription factor activity
IXO704_RS05350	COG4191	Histidine kinase
IXO704_RS05370	COG0280	phosphate acetyltransferase
IXO704_RS05370	COG0281	malic enzyme
IXO704_RS05435	COG0352	thiamine-phosphate diphosphorylase activity
IXO704_RS05440	COG1773	rubredoxin
IXO704_RS05445	COG2912	Transglutaminase-like superfamily
IXO704_RS05455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO704_RS05465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO704_RS05490	COG0006	proline dipeptidase activity
IXO704_RS05525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO704_RS05540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO704_RS05545	COG1561	YicC-like family, N-terminal region
IXO704_RS05570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO704_RS05580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO704_RS05605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO704_RS05650	COG0714	Associated with various cellular activities
IXO704_RS05670	COG2304	oxidoreductase activity
IXO704_RS05690	COG1301	dicarboxylic acid transport
IXO704_RS05695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO704_RS05705	COG0739	heme binding
IXO704_RS05710	COG1376	ErfK ybiS ycfS ynhG family protein
IXO704_RS05735	COG1022	Amp-dependent synthetase and ligase
IXO704_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS05755	COG0745	RESPONSE REGULATOR receiver
IXO704_RS05760	COG0642	Histidine kinase
IXO704_RS05780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO704_RS05785	COG4149	molybdate abc transporter
IXO704_RS05790	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO704_RS05795	COG3453	Protein conserved in bacteria
IXO704_RS05795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO704_RS05835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO704_RS05855	COG2205	protein histidine kinase activity
IXO704_RS05860	COG0745	RESPONSE REGULATOR receiver
IXO704_RS05910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO704_RS05915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO704_RS05960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO704_RS05975	COG2801	Transposase and inactivated derivatives
IXO704_RS06015	COG2201	protein-glutamate methylesterase activity
IXO704_RS06045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO704_RS06055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO704_RS06060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO704_RS06075	COG1842	Phage shock protein A
IXO704_RS06100	COG0754	glutathionylspermidine amidase activity
IXO704_RS06160	COG0531	amino acid
IXO704_RS06165	COG2197	response regulator
IXO704_RS06180	COG1113	amino acid transport
IXO704_RS06195	COG1271	oxidase subunit
IXO704_RS06200	COG1294	oxidase, subunit
IXO704_RS06210	COG2239	Acts as a magnesium transporter
IXO704_RS06215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO704_RS06220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO704_RS06235	COG1660	Displays ATPase and GTPase activities
IXO704_RS06240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO704_RS06245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO704_RS06260	COG1137	ATPase activity
IXO704_RS06265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO704_RS06275	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO704_RS06285	COG0271	Belongs to the BolA IbaG family
IXO704_RS06290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO704_RS06310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO704_RS06325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO704_RS06335	COG0628	permease
IXO704_RS06345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO704_RS06350	COG3178	'Phosphotransferase
IXO704_RS06365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO704_RS06370	COG1555	photosystem II stabilization
IXO704_RS06420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO704_RS06430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO704_RS06450	COG0228	four-way junction DNA binding
IXO704_RS06455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO704_RS06460	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO704_RS06475	COG0534	Mate efflux family protein
IXO704_RS06510	COG0542	response to heat
IXO704_RS06545	COG4206	TonB-dependent receptor
IXO704_RS06605	COG0019	diaminopimelate decarboxylase activity
IXO704_RS06615	COG2814	Major facilitator Superfamily
IXO704_RS06620	COG4264	IucA IucC family
IXO704_RS06630	COG4772	TonB-dependent receptor
IXO704_RS06645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO704_RS06645	COG4651	solute:proton antiporter activity
IXO704_RS06685	COG0488	(ABC) transporter
IXO704_RS06710	COG2755	lipolytic protein G-D-S-L family
IXO704_RS06710	COG0657	acetylesterase activity
IXO704_RS06755	COG2207	Transcriptional regulator
IXO704_RS06760	COG0326	Molecular chaperone. Has ATPase activity
IXO704_RS06785	COG3328	transposase activity
IXO704_RS06790	COG0174	glutamine synthetase
IXO704_RS06795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO704_RS06805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO704_RS06820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO704_RS06845	COG2146	nitrite reductase [NAD(P)H] activity
IXO704_RS06855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO704_RS06860	COG0719	Fe-S assembly protein
IXO704_RS06865	COG0396	ATPase activity
IXO704_RS06870	COG0719	Fe-S assembly protein
IXO704_RS06875	COG1959	2 iron, 2 sulfur cluster binding
IXO704_RS06895	COG0693	protein deglycase activity
IXO704_RS06935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO704_RS06965	COG0519	Catalyzes the synthesis of GMP from XMP
IXO704_RS06975	COG1678	Uncharacterized ACR, COG1678
IXO704_RS06980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO704_RS07010	COG1764	response to oxidative stress
IXO704_RS07020	COG0384	phenazine biosynthesis protein PhzF
IXO704_RS07030	COG0527	aspartate kinase activity
IXO704_RS07055	COG0142	geranyltranstransferase activity
IXO704_RS07060	COG0629	single-stranded DNA binding
IXO704_RS07065	COG4251	negative regulation of phosphorylation
IXO704_RS07065	COG5001	Diguanylate cyclase
IXO704_RS07065	COG2203	Gaf domain
IXO704_RS07065	COG3706	GGDEF domain
IXO704_RS07095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO704_RS07140	COG2879	small protein
IXO704_RS07145	COG1966	Carbon starvation protein
IXO704_RS07150	COG1741	Belongs to the pirin family
IXO704_RS07160	COG3501	Rhs element vgr protein
IXO704_RS07195	COG1741	Belongs to the pirin family
IXO704_RS07205	COG1515	deoxyribonuclease V activity
IXO704_RS07210	COG0588	phosphoglycerate mutase activity
IXO704_RS07225	COG3590	peptidase
IXO704_RS07240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO704_RS07245	COG2199	diguanylate cyclase activity
IXO704_RS07245	COG2200	EAL domain
IXO704_RS07245	COG2202	Pas domain
IXO704_RS07250	COG0835	chemotaxis
IXO704_RS07255	COG0840	transmembrane signaling receptor activity
IXO704_RS07260	COG0643	Histidine kinase
IXO704_RS07260	COG2198	Histidine kinase
IXO704_RS07275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO704_RS07285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO704_RS07295	COG2205	protein histidine kinase activity
IXO704_RS07345	COG3039	Transposase
IXO704_RS07370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO704_RS07375	COG0735	belongs to the Fur family
IXO704_RS07435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO704_RS07440	COG0084	hydrolase, TatD family'
IXO704_RS07455	COG1960	acyl-CoA dehydrogenase activity
IXO704_RS07470	COG0367	asparagine synthase
IXO704_RS07480	COG0305	Participates in initiation and elongation during chromosome replication
IXO704_RS07485	COG0415	Belongs to the DNA photolyase family
IXO704_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS07600	COG5002	protein histidine kinase activity
IXO704_RS07600	COG5001	Diguanylate cyclase
IXO704_RS07605	COG1187	pseudouridine synthase activity
IXO704_RS07625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO704_RS07635	COG0475	glutathione-regulated potassium exporter activity
IXO704_RS07640	COG5000	phosphorelay sensor kinase activity
IXO704_RS07640	COG5002	protein histidine kinase activity
IXO704_RS07645	COG0745	RESPONSE REGULATOR receiver
IXO704_RS07675	COG1132	(ABC) transporter
IXO704_RS07705	COG3039	Transposase
IXO704_RS07720	COG3039	Transposase
IXO704_RS07750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO704_RS07760	COG4969	Belongs to the N-Me-Phe pilin family
IXO704_RS07765	COG2194	sulfuric ester hydrolase activity
IXO704_RS07805	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO704_RS07810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO704_RS07820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO704_RS07820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO704_RS07825	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO704_RS07830	COG0564	pseudouridine synthase activity
IXO704_RS07855	COG3387	PFAM Glycoside hydrolase 15-related
IXO704_RS07860	COG1877	trehalose-phosphatase activity
IXO704_RS07900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO704_RS07915	COG1595	DNA-templated transcription, initiation
IXO704_RS07925	COG1946	Acyl-CoA thioesterase
IXO704_RS07940	COG0824	Thioesterase
IXO704_RS07945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO704_RS07955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO704_RS07960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO704_RS07965	COG0268	Binds directly to 16S ribosomal RNA
IXO704_RS07970	COG0728	peptidoglycan biosynthetic process
IXO704_RS07975	COG0196	riboflavin kinase activity
IXO704_RS07985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO704_RS07990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO704_RS08005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO704_RS08010	COG1845	cytochrome c oxidase, subunit III
IXO704_RS08015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO704_RS08025	COG3501	Rhs element vgr protein
IXO704_RS08035	COG3209	COG3209 Rhs family protein
IXO704_RS08045	COG3328	transposase activity
IXO704_RS08155	COG0632	four-way junction helicase activity
IXO704_RS08165	COG2255	four-way junction helicase activity
IXO704_RS08170	COG0824	Thioesterase
IXO704_RS08180	COG0848	biopolymer transport protein
IXO704_RS08195	COG2885	chlorophyll binding
IXO704_RS08205	COG0602	queuosine metabolic process
IXO704_RS08210	COG1187	pseudouridine synthase activity
IXO704_RS08275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO704_RS08295	COG0514	ATP-dependent DNA helicase (RecQ)
IXO704_RS08300	COG0783	Belongs to the Dps family
IXO704_RS08305	COG1643	Atp-dependent helicase
IXO704_RS08345	COG0535	radical SAM domain protein
IXO704_RS08350	COG0535	radical SAM domain protein
IXO704_RS08370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO704_RS08380	COG1215	transferase activity, transferring glycosyl groups
IXO704_RS08385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO704_RS08395	COG1199	ATP-dependent helicase activity
IXO704_RS08405	COG1397	ADP-ribosylglycohydrolase
IXO704_RS08415	COG0189	ligase activity
IXO704_RS08430	COG0835	chemotaxis
IXO704_RS08435	COG0840	transmembrane signaling receptor activity
IXO704_RS08440	COG0643	Histidine kinase
IXO704_RS08440	COG2198	Histidine kinase
IXO704_RS08440	COG0784	Response regulator, receiver
IXO704_RS08460	COG3039	Transposase
IXO704_RS08485	COG1446	asparaginase
IXO704_RS08530	COG3537	Alpha-1,2-mannosidase
IXO704_RS08570	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO704_RS08580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO704_RS08590	COG3858	chitin binding
IXO704_RS08590	COG1388	LysM domain
IXO704_RS08605	COG0837	glucose binding
IXO704_RS08610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO704_RS08620	COG0494	nUDIX hydrolase
IXO704_RS08630	COG3956	TIGRFAM MazG family protein
IXO704_RS08645	COG0330	HflC and HflK could
IXO704_RS08660	COG0509	glycine decarboxylation via glycine cleavage system
IXO704_RS08675	COG3039	Transposase
IXO704_RS08695	COG1960	acyl-CoA dehydrogenase activity
IXO704_RS08705	COG1309	transcriptional regulator
IXO704_RS08710	COG4771	TonB-dependent receptor
IXO704_RS08720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO704_RS08730	COG0463	Glycosyl transferase, family 2
IXO704_RS08750	COG1272	protein, Hemolysin III
IXO704_RS08760	COG0739	heme binding
IXO704_RS08765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO704_RS08770	COG0626	cystathionine gamma-synthase activity
IXO704_RS08780	COG1760	l-serine dehydratase
IXO704_RS08795	COG2353	YceI-like domain
IXO704_RS08805	COG2353	YceI-like domain
IXO704_RS08850	COG3250	beta-galactosidase activity
IXO704_RS08855	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IXO704_RS08875	COG1960	acyl-CoA dehydrogenase activity
IXO704_RS08880	COG1024	Enoyl-CoA hydratase
IXO704_RS08905	COG1024	Enoyl-CoA hydratase
IXO704_RS08905	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO704_RS08920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO704_RS08925	COG0481	GTPase activity
IXO704_RS08950	COG1381	Involved in DNA repair and RecF pathway recombination
IXO704_RS08965	COG2954	triphosphatase activity
IXO704_RS08975	COG3039	Transposase
IXO704_RS08980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO704_RS08985	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO704_RS08990	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO704_RS09005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO704_RS09010	COG1278	Cold shock
IXO704_RS09030	COG1201	RNA secondary structure unwinding
IXO704_RS09035	COG1793	dna ligase
IXO704_RS09045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO704_RS09045	COG1793	dna ligase
IXO704_RS09075	COG0183	Belongs to the thiolase family
IXO704_RS09110	COG1451	nucleotide metabolic process
IXO704_RS09125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO704_RS09160	COG1047	Peptidyl-prolyl cis-trans
IXO704_RS09175	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO704_RS09185	COG1902	pentaerythritol trinitrate reductase activity
IXO704_RS09190	COG2814	Major facilitator Superfamily
IXO704_RS09215	COG3039	Transposase
IXO704_RS09245	COG0392	lysyltransferase activity
IXO704_RS09245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO704_RS09255	COG0251	oxidation-reduction process
IXO704_RS09260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO704_RS09275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO704_RS09300	COG1595	DNA-templated transcription, initiation
IXO704_RS09315	COG2878	Part of a membrane complex involved in electron transport
IXO704_RS09325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO704_RS09325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO704_RS09345	COG0833	amino acid
IXO704_RS09350	COG2040	homocysteine
IXO704_RS09365	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO704_RS09405	COG0529	Catalyzes the synthesis of activated sulfate
IXO704_RS09405	COG2895	sulfate adenylyltransferase (ATP) activity
IXO704_RS09480	COG4771	TonB-dependent receptor
IXO704_RS09490	COG0825	malonyl-CoA metabolic process
IXO704_RS09510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO704_RS09515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO704_RS09530	COG0750	zinc metalloprotease
IXO704_RS09540	COG0575	Belongs to the CDS family
IXO704_RS09550	COG0233	cytoplasmic translational termination
IXO704_RS09565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO704_RS09625	COG1393	Belongs to the ArsC family
IXO704_RS09635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO704_RS09640	COG0367	asparagine synthase
IXO704_RS09650	COG4774	siderophore transport
IXO704_RS09690	COG1566	PFAM secretion protein HlyD family protein
IXO704_RS09695	COG2814	Major facilitator Superfamily
IXO704_RS09750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO704_RS09760	COG1960	acyl-CoA dehydrogenase activity
IXO704_RS09775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO704_RS09785	COG2914	Belongs to the UPF0125 (RnfH) family
IXO704_RS09790	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO704_RS09800	COG0497	DNA recombination
IXO704_RS09810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO704_RS09820	COG0484	heat shock protein binding
IXO704_RS09825	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO704_RS09830	COG1605	Chorismate mutase
IXO704_RS09830	COG0287	Prephenate dehydrogenase
IXO704_RS09845	COG0583	DNA-binding transcription factor activity
IXO704_RS09860	COG1132	(ABC) transporter
IXO704_RS09895	COG2850	peptidyl-arginine hydroxylation
IXO704_RS09975	COG1131	(ABC) transporter
IXO704_RS09980	COG1725	Transcriptional regulator
IXO704_RS09990	COG0386	Belongs to the glutathione peroxidase family
IXO704_RS10005	COG2900	Belongs to the SlyX family
IXO704_RS10030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO704_RS10040	COG1410	methionine synthase
IXO704_RS10040	COG0646	methionine synthase
IXO704_RS10045	COG0646	methionine synthase
IXO704_RS10045	COG1410	methionine synthase
IXO704_RS10050	COG2226	methyltransferase
IXO704_RS10055	COG1960	acyl-CoA dehydrogenase activity
IXO704_RS10080	COG0557	exoribonuclease II activity
IXO704_RS10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO704_RS10110	COG3039	Transposase
IXO704_RS10180	COG3842	ATPase activity
IXO704_RS10190	COG1177	transmembrane transport
IXO704_RS10200	COG1012	belongs to the aldehyde dehydrogenase family
IXO704_RS10215	COG4535	Mg2 and Co2 transporter CorC
IXO704_RS10235	COG1702	phosphate starvation-inducible protein PhoH
IXO704_RS10260	COG0741	lytic transglycosylase activity
IXO704_RS10265	COG0723	plastoquinol--plastocyanin reductase activity
IXO704_RS10270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO704_RS10275	COG2857	Cytochrome c1
IXO704_RS10280	COG0625	glutathione transferase activity
IXO704_RS10285	COG2969	positive regulation of protein catabolic process
IXO704_RS10320	COG3328	transposase activity
IXO704_RS10405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO704_RS10425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO704_RS10430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO704_RS10430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO704_RS10435	COG0802	atpase or kinase
IXO704_RS10440	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO704_RS10445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO704_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS10475	COG0501	Belongs to the peptidase M48B family
IXO704_RS10485	COG2081	HI0933 family
IXO704_RS10490	COG4681	YaeQ
IXO704_RS10495	COG1671	Belongs to the UPF0178 family
IXO704_RS10505	COG0625	glutathione transferase activity
IXO704_RS10515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO704_RS10520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO704_RS10525	COG0513	Belongs to the DEAD box helicase family
IXO704_RS10550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO704_RS10555	COG0483	inositol monophosphate 1-phosphatase activity
IXO704_RS10570	COG3300	MHYT domain
IXO704_RS10570	COG5001	Diguanylate cyclase
IXO704_RS10575	COG1509	lysine 2,3-aminomutase activity
IXO704_RS10590	COG0402	S-adenosylhomocysteine deaminase activity
IXO704_RS10595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO704_RS10620	COG4677	pectinesterase activity
IXO704_RS10630	COG3039	Transposase
IXO704_RS10665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO704_RS10690	COG2166	iron-sulfur cluster assembly
IXO704_RS10705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO704_RS10710	COG0137	argininosuccinate synthase activity
IXO704_RS10720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO704_RS10725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO704_RS10740	COG0165	Argininosuccinate lyase
IXO704_RS10760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO704_RS10790	COG1271	oxidase subunit
IXO704_RS10800	COG4988	ABC transporter
IXO704_RS10805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO704_RS10890	COG3039	Transposase
IXO704_RS10905	COG3209	COG3209 Rhs family protein
IXO704_RS10940	COG3039	Transposase
IXO704_RS10965	COG0643	Histidine kinase
IXO704_RS10965	COG0784	Response regulator, receiver
IXO704_RS10965	COG2198	Histidine kinase
IXO704_RS11010	COG5001	Diguanylate cyclase
IXO704_RS11010	COG3300	MHYT domain
IXO704_RS11015	COG3300	MHYT domain
IXO704_RS11015	COG5001	Diguanylate cyclase
IXO704_RS11020	COG1684	flagellar biosynthetic protein fliR
IXO704_RS11035	COG3190	flagellar
IXO704_RS11085	COG1677	Flagellar hook-basal body complex protein FliE
IXO704_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS11125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO704_RS11145	COG2201	protein-glutamate methylesterase activity
IXO704_RS11175	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO704_RS11180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO704_RS11220	COG4787	bacterial-type flagellum-dependent cell motility
IXO704_RS11230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO704_RS11235	COG1558	bacterial-type flagellum-dependent cell motility
IXO704_RS11245	COG0835	chemotaxis
IXO704_RS11245	COG0784	Response regulator, receiver
IXO704_RS11265	COG5002	protein histidine kinase activity
IXO704_RS11275	COG4585	Histidine kinase
IXO704_RS11280	COG5001	Diguanylate cyclase
IXO704_RS11305	COG0482	sulfurtransferase activity
IXO704_RS11320	COG0542	response to heat
IXO704_RS11345	COG0492	ferredoxin-NADP+ reductase activity
IXO704_RS11350	COG1674	ftsk spoiiie
IXO704_RS11370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO704_RS11390	COG0038	chloride channel
IXO704_RS11395	COG0183	Belongs to the thiolase family
IXO704_RS11400	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO704_RS11400	COG1024	Enoyl-CoA hydratase
IXO704_RS11415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO704_RS11425	COG1426	Protein conserved in bacteria
IXO704_RS11435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO704_RS11445	COG0303	'Molybdopterin
IXO704_RS11505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO704_RS11545	COG0742	ribosomal rna small subunit methyltransferase
IXO704_RS11550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO704_RS11560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO704_RS11565	COG0405	Gamma-glutamyltransferase
IXO704_RS11590	COG3039	Transposase
IXO704_RS11625	COG3039	Transposase
IXO704_RS11675	COG0343	queuine tRNA-ribosyltransferase activity
IXO704_RS11680	COG1862	Preprotein translocase
IXO704_RS11685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO704_RS11690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO704_RS11725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO704_RS11735	COG0704	Plays a role in the regulation of phosphate uptake
IXO704_RS11750	COG0573	inorganic phosphate transmembrane transporter activity
IXO704_RS11755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO704_RS11795	COG3039	Transposase
IXO704_RS11815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO704_RS11825	COG1024	Enoyl-CoA hydratase
IXO704_RS11835	COG0494	nUDIX hydrolase
IXO704_RS11880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO704_RS11880	COG0116	Belongs to the methyltransferase superfamily
IXO704_RS11905	COG0667	Aldo Keto reductase
IXO704_RS11915	COG2925	Exonuclease
IXO704_RS11950	COG0288	reversible hydration of carbon dioxide
IXO704_RS11980	COG0316	Belongs to the HesB IscA family
IXO704_RS11985	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO704_RS11995	COG0359	binds to the 23S rRNA
IXO704_RS12005	COG3115	cell septum assembly
IXO704_RS12025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO704_RS12040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO704_RS12065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO704_RS12075	COG2986	histidine ammonia-lyase
IXO704_RS12080	COG1228	amidohydrolase
IXO704_RS12120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO704_RS12130	COG1605	Chorismate mutase
IXO704_RS12130	COG0077	Prephenate dehydratase
IXO704_RS12135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO704_RS12160	COG3039	Transposase
IXO704_RS12170	COG4566	intracellular signal transduction
IXO704_RS12215	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO704_RS12220	COG1469	GTP cyclohydrolase I activity
IXO704_RS12230	COG0617	tRNA 3'-terminal CCA addition
IXO704_RS12240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO704_RS12245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO704_RS12275	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO704_RS12295	COG3706	GGDEF domain
IXO704_RS12295	COG4251	negative regulation of phosphorylation
IXO704_RS12295	COG5001	Diguanylate cyclase
IXO704_RS12295	COG2203	Gaf domain
IXO704_RS12320	COG3104	oligopeptide transport
IXO704_RS12380	COG0386	Belongs to the glutathione peroxidase family
IXO704_RS12430	COG3706	GGDEF domain
IXO704_RS12450	COG3039	Transposase
IXO704_RS12465	COG0784	Response regulator, receiver
IXO704_RS12465	COG5002	protein histidine kinase activity
IXO704_RS12465	COG2205	protein histidine kinase activity
IXO704_RS12505	COG0800	Aldolase
IXO704_RS12510	COG0129	dihydroxy-acid dehydratase activity
IXO704_RS12515	COG0363	glucosamine-6-phosphate deaminase activity
IXO704_RS12525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO704_RS12540	COG0354	folic acid binding
IXO704_RS12555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO704_RS12570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO704_RS12585	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO704_RS12610	COG0811	peptide transport
IXO704_RS12625	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO704_RS12635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO704_RS12645	COG0322	excinuclease ABC activity
IXO704_RS12680	COG3328	transposase activity
IXO704_RS12715	COG2801	Transposase and inactivated derivatives
IXO704_RS12725	COG2201	protein-glutamate methylesterase activity
IXO704_RS12785	COG3039	Transposase
IXO704_RS12810	COG0653	protein targeting
IXO704_RS12845	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO704_RS12845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO704_RS12855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO704_RS12865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO704_RS12865	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO704_RS12880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO704_RS12900	COG0124	histidyl-tRNA synthetase
IXO704_RS12915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO704_RS12950	COG1012	belongs to the aldehyde dehydrogenase family
IXO704_RS12970	COG0167	dihydroorotate dehydrogenase activity
IXO704_RS12975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO704_RS12980	COG0697	spore germination
IXO704_RS12985	COG1794	racemase activity, acting on amino acids and derivatives
IXO704_RS13010	COG0671	phosphoesterase, PA-phosphatase related
IXO704_RS13025	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO704_RS13040	COG2183	response to ionizing radiation
IXO704_RS13050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO704_RS13050	COG0723	plastoquinol--plastocyanin reductase activity
IXO704_RS13065	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO704_RS13075	COG1183	phosphatidylcholine synthase activity
IXO704_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS13095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IXO704_RS13105	COG0668	transmembrane transport
IXO704_RS13125	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO704_RS13170	COG0583	DNA-binding transcription factor activity
IXO704_RS13175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO704_RS13180	COG3002	Belongs to the UPF0753 family
IXO704_RS13275	COG0582	viral genome integration into host DNA
IXO704_RS13290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO704_RS13310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO704_RS13320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO704_RS13325	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO704_RS13335	COG0776	regulation of translation
IXO704_RS13340	COG0539	negative regulation of cytoplasmic translation
IXO704_RS13345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO704_RS13360	COG2957	Belongs to the agmatine deiminase family
IXO704_RS13370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO704_RS13395	COG0395	ABC-type sugar transport system, permease component
IXO704_RS13400	COG1175	transmembrane transport
IXO704_RS13430	COG2350	Protein conserved in bacteria
IXO704_RS13435	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO704_RS13440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO704_RS13445	COG1187	pseudouridine synthase activity
IXO704_RS13470	COG0436	Aminotransferase
IXO704_RS13535	COG0277	FAD linked oxidase domain protein
IXO704_RS13540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO704_RS13550	COG0531	amino acid
IXO704_RS13555	COG0531	amino acid
IXO704_RS13560	COG0235	Class ii aldolase
IXO704_RS13565	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO704_RS13645	COG0583	DNA-binding transcription factor activity
IXO704_RS13655	COG3039	Transposase
IXO704_RS13735	COG0174	glutamine synthetase
IXO704_RS13740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO704_RS13750	COG0477	Major facilitator Superfamily
IXO704_RS13760	COG0243	molybdopterin cofactor binding
IXO704_RS13770	COG2223	nitrite transmembrane transporter activity
IXO704_RS13780	COG1121	(ABC) transporter
IXO704_RS13790	COG2733	membrane
IXO704_RS13795	COG5002	protein histidine kinase activity
IXO704_RS13795	COG2205	protein histidine kinase activity
IXO704_RS13795	COG0784	Response regulator, receiver
IXO704_RS13805	COG3039	Transposase
IXO704_RS13810	COG2902	Dehydrogenase
IXO704_RS13820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO704_RS13825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO704_RS13850	COG1609	Transcriptional regulator
IXO704_RS13855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO704_RS13855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO704_RS13860	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO704_RS13865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO704_RS13865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO704_RS13880	COG3039	Transposase
IXO704_RS13910	COG3039	Transposase
IXO704_RS13935	COG3501	Rhs element vgr protein
IXO704_RS13950	COG3501	Rhs element vgr protein
IXO704_RS13965	COG3501	Rhs element vgr protein
IXO704_RS14000	COG4771	TonB-dependent receptor
IXO704_RS14010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO704_RS14030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO704_RS14035	COG1360	Flagellar Motor Protein
IXO704_RS14045	COG0835	chemotaxis
IXO704_RS14055	COG0745	RESPONSE REGULATOR receiver
IXO704_RS14075	COG0840	transmembrane signaling receptor activity
IXO704_RS14085	COG0840	transmembrane signaling receptor activity
IXO704_RS14095	COG0840	transmembrane signaling receptor activity
IXO704_RS14105	COG0840	transmembrane signaling receptor activity
IXO704_RS14110	COG0840	transmembrane signaling receptor activity
IXO704_RS14115	COG0840	transmembrane signaling receptor activity
IXO704_RS14120	COG0840	transmembrane signaling receptor activity
IXO704_RS14135	COG0835	chemotaxis
IXO704_RS14155	COG3039	Transposase
IXO704_RS14215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO704_RS14245	COG0318	PFAM AMP-dependent synthetase and ligase
IXO704_RS14250	COG1024	Enoyl-CoA hydratase
IXO704_RS14255	COG0784	Response regulator, receiver
IXO704_RS14255	COG2198	Histidine kinase
IXO704_RS14255	COG2205	protein histidine kinase activity
IXO704_RS14265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IXO704_RS14320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO704_RS14330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO704_RS14335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO704_RS14345	COG0505	Belongs to the CarA family
IXO704_RS14350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO704_RS14360	COG2258	MOSC domain
IXO704_RS14365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO704_RS14415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO704_RS14435	COG0477	Major facilitator Superfamily
IXO704_RS14445	COG1070	Carbohydrate kinase
IXO704_RS14455	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO704_RS14470	COG0800	Aldolase
IXO704_RS14475	COG4948	Mandelate Racemase Muconate Lactonizing
IXO704_RS14485	COG3734	2-keto-3-deoxy-galactonokinase
IXO704_RS14490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO704_RS14500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO704_RS14515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO704_RS14520	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO704_RS14530	COG0351	phosphomethylpyrimidine kinase
IXO704_RS14560	COG0583	DNA-binding transcription factor activity
IXO704_RS14565	COG1741	Belongs to the pirin family
IXO704_RS14585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO704_RS14590	COG0305	Participates in initiation and elongation during chromosome replication
IXO704_RS14615	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO704_RS14620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO704_RS14625	COG2137	regulation of response to DNA damage stimulus
IXO704_RS14630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO704_RS14645	COG1546	Belongs to the CinA family
IXO704_RS14650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO704_RS14660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO704_RS14665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO704_RS14675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO704_RS14680	COG1534	Rna-binding protein
IXO704_RS14695	COG1238	metal cluster binding
IXO704_RS14700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO704_RS14705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO704_RS14710	COG2840	Smr protein MutS2
IXO704_RS14720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO704_RS14730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO704_RS14735	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO704_RS14740	COG0148	phosphopyruvate hydratase activity
IXO704_RS14750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO704_RS14755	COG0504	CTP synthase activity
IXO704_RS14785	COG0306	phosphate transporter
IXO704_RS14795	COG1253	flavin adenine dinucleotide binding
IXO704_RS14810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO704_RS14820	COG0477	Major facilitator Superfamily
IXO704_RS14830	COG1132	(ABC) transporter
IXO704_RS14835	COG1136	(ABC) transporter
IXO704_RS14850	COG0438	transferase activity, transferring glycosyl groups
IXO704_RS14860	COG2264	protein methyltransferase activity
IXO704_RS14890	COG2244	polysaccharide biosynthetic process
IXO704_RS14940	COG1595	DNA-templated transcription, initiation
IXO704_RS14955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO704_RS14975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO704_RS15005	COG2201	protein-glutamate methylesterase activity
IXO704_RS15025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO704_RS15080	COG1858	cytochrome C peroxidase
IXO704_RS15110	COG0515	serine threonine protein kinase
IXO704_RS15115	COG0631	protein serine/threonine phosphatase activity
IXO704_RS15150	COG3501	Rhs element vgr protein
IXO704_RS15235	COG3039	Transposase
IXO704_RS15300	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO704_RS15310	COG0428	transporter
IXO704_RS15315	COG0428	transporter
IXO704_RS15320	COG3064	Membrane
IXO704_RS15330	COG1530	ribonuclease E activity
IXO704_RS15370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO704_RS15410	COG3039	Transposase
IXO704_RS15420	COG3039	Transposase
IXO704_RS15460	COG1648	precorrin-2 dehydrogenase activity
IXO704_RS15460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO704_RS15485	COG0746	molybdenum cofactor guanylyltransferase activity
IXO704_RS15570	COG4206	TonB-dependent receptor
IXO704_RS15600	COG0531	amino acid
IXO704_RS15615	COG0006	proline dipeptidase activity
IXO704_RS15625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO704_RS15640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO704_RS15645	COG3938	Belongs to the proline racemase family
IXO704_RS15655	COG0552	protein localization to endoplasmic reticulum
IXO704_RS15665	COG1194	a g-specific adenine glycosylase
IXO704_RS15675	COG4191	Histidine kinase
IXO704_RS15675	COG0784	Response regulator, receiver
IXO704_RS15745	COG3039	Transposase
IXO704_RS15775	COG3040	lipid binding
IXO704_RS15815	COG0438	transferase activity, transferring glycosyl groups
IXO704_RS15825	COG0438	transferase activity, transferring glycosyl groups
IXO704_RS15830	COG0438	transferase activity, transferring glycosyl groups
IXO704_RS15885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO704_RS15900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO704_RS15940	COG0556	nucleotide-excision repair
IXO704_RS15945	COG4969	Belongs to the N-Me-Phe pilin family
IXO704_RS15985	COG1611	Belongs to the LOG family
IXO704_RS16000	COG2095	MarC family integral membrane protein
IXO704_RS16010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO704_RS16045	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO704_RS16050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO704_RS16070	COG0195	Participates in both transcription termination and antitermination
IXO704_RS16075	COG0779	Required for maturation of 30S ribosomal subunits
IXO704_RS16085	COG1007	ATP synthesis coupled electron transport
IXO704_RS16115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO704_RS16120	COG1034	ATP synthesis coupled electron transport
IXO704_RS16125	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO704_RS16130	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO704_RS16135	COG0649	NAD binding
IXO704_RS16140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO704_RS16150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO704_RS16165	COG0149	triose-phosphate isomerase activity
IXO704_RS16215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO704_RS16220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO704_RS16225	COG0159	tryptophan synthase activity
IXO704_RS16245	COG0135	phosphoribosylanthranilate isomerase activity
IXO704_RS16250	COG0101	tRNA pseudouridine synthase activity
IXO704_RS16270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO704_RS16275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO704_RS16280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO704_RS16285	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO704_RS16310	COG0433	COG0433 Predicted ATPase
IXO704_RS16315	COG2826	transposase and inactivated derivatives, IS30 family
IXO704_RS16330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO704_RS16340	COG0412	Dienelactone hydrolase
IXO704_RS16360	COG0717	Belongs to the dCTP deaminase family
IXO704_RS16365	COG0489	protein tyrosine kinase activity
IXO704_RS16405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO704_RS16410	COG2311	Membrane
IXO704_RS16415	COG1047	Peptidyl-prolyl cis-trans
IXO704_RS16420	COG0791	NLP P60 protein
IXO704_RS16425	COG0791	NLP P60 protein
IXO704_RS16440	COG1301	dicarboxylic acid transport
IXO704_RS16445	COG1785	Belongs to the alkaline phosphatase family
IXO704_RS16450	COG0037	tRNA processing
IXO704_RS16455	COG1722	exodeoxyribonuclease VII activity
IXO704_RS16460	COG0142	geranyltranstransferase activity
IXO704_RS16485	COG0312	modulator of DNA gyrase
IXO704_RS16490	COG3028	Belongs to the UPF0307 family
IXO704_RS16495	COG0312	modulator of DNA gyrase
IXO704_RS16505	COG3164	Protein of unknown function
IXO704_RS16510	COG1530	ribonuclease E activity
IXO704_RS16520	COG2968	Membrane
IXO704_RS16550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO704_RS16575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO704_RS16600	COG3118	belongs to the thioredoxin family
IXO704_RS16640	COG3039	Transposase
IXO704_RS16680	COG3039	Transposase
IXO704_RS16780	COG2022	thiamine diphosphate biosynthetic process
IXO704_RS16790	COG3273	potassium ion transport
IXO704_RS16790	COG0471	metal ion transport
IXO704_RS16820	COG1970	mechanosensitive ion channel activity
IXO704_RS16840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO704_RS16860	COG0308	aminopeptidase N
IXO704_RS16865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO704_RS16875	COG2895	sulfate adenylyltransferase (ATP) activity
IXO704_RS16875	COG0529	Catalyzes the synthesis of activated sulfate
IXO704_RS16880	COG0175	sulfate reduction
IXO704_RS16885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO704_RS16890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO704_RS16895	COG0175	sulfate reduction
IXO704_RS16915	COG0784	Response regulator, receiver
IXO704_RS16915	COG2198	Histidine kinase
IXO704_RS16915	COG2205	protein histidine kinase activity
IXO704_RS16965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO704_RS16970	COG3588	fructose-bisphosphate aldolase
IXO704_RS16975	COG0469	pyruvate kinase activity
IXO704_RS17015	COG0753	catalase activity
IXO704_RS17040	COG2207	Transcriptional regulator
IXO704_RS17040	COG1917	Cupin 2, conserved barrel domain protein
IXO704_RS17060	COG1506	peptidase
IXO704_RS17060	COG0823	Involved in the tonB-independent uptake of proteins
IXO704_RS17080	COG1297	OPT oligopeptide transporter protein
IXO704_RS17095	COG0587	DNA-directed DNA polymerase activity
IXO704_RS17170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO704_RS17175	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO704_RS17180	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO704_RS17185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO704_RS17205	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO704_RS17255	COG3501	Rhs element vgr protein
IXO704_RS17265	COG3039	Transposase
IXO704_RS17325	COG3501	Rhs element vgr protein
IXO704_RS17395	COG3501	Rhs element vgr protein
IXO704_RS17400	COG3179	chitinase
IXO704_RS17410	COG3501	Rhs element vgr protein
IXO704_RS17425	COG3039	Transposase
IXO704_RS17450	COG3501	Rhs element vgr protein
IXO704_RS17525	COG3501	Rhs element vgr protein
IXO704_RS17530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO704_RS17540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO704_RS17550	COG3501	Rhs element vgr protein
IXO704_RS17635	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO704_RS17650	COG2197	response regulator
IXO704_RS17655	COG4585	Histidine kinase
IXO704_RS17670	COG2894	cell division
IXO704_RS17675	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO704_RS17685	COG0642	Histidine kinase
IXO704_RS17690	COG0745	RESPONSE REGULATOR receiver
IXO704_RS17695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO704_RS17705	COG2194	sulfuric ester hydrolase activity
IXO704_RS17735	COG3551	Protein conserved in bacteria
IXO704_RS17795	COG0203	ribosomal protein L17
IXO704_RS17805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO704_RS17810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO704_RS17820	COG0201	protein transport
IXO704_RS17830	COG1841	ribosomal large subunit assembly
IXO704_RS17840	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IXO704_RS17860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO704_RS17870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO704_RS17875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO704_RS17880	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO704_RS17885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO704_RS17895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO704_RS17910	COG0089	rRNA binding
IXO704_RS17915	COG0088	Forms part of the polypeptide exit tunnel
IXO704_RS17920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO704_RS17925	COG0051	transcription antitermination factor activity, RNA binding
IXO704_RS17945	COG0049	tRNA binding
IXO704_RS17950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO704_RS17955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO704_RS17960	COG0085	RNA polymerase activity
IXO704_RS17965	COG0222	ribosome binding
IXO704_RS17970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO704_RS17980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO704_RS17985	COG0250	Participates in transcription elongation, termination and antitermination
IXO704_RS17990	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO704_RS18020	COG0012	GTP binding
IXO704_RS18025	COG0193	aminoacyl-tRNA hydrolase activity
IXO704_RS18035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO704_RS18050	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO704_RS18060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO704_RS18065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO704_RS18080	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO704_RS18100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO704_RS18105	COG1295	ribonuclease BN
IXO704_RS18135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO704_RS18140	COG1404	Belongs to the peptidase S8 family
IXO704_RS18145	COG1404	Belongs to the peptidase S8 family
IXO704_RS18155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO704_RS18180	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO704_RS18205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO704_RS18220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO704_RS18220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO704_RS18265	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO704_RS18275	COG3634	alkyl hydroperoxide reductase activity
IXO704_RS18280	COG0583	DNA-binding transcription factor activity
IXO704_RS18290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO704_RS18315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO704_RS18350	COG0584	glycerophosphoryl diester phosphodiesterase
IXO704_RS18370	COG3039	Transposase
IXO704_RS18385	COG0625	glutathione transferase activity
IXO704_RS18390	COG0039	L-malate dehydrogenase activity
IXO704_RS18395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO704_RS18420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO704_RS18555	COG3781	membrane
IXO704_RS18565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO704_RS18595	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO704_RS18615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO704_RS18640	COG3710	Transcriptional regulator
IXO704_RS18645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO704_RS18655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO704_RS18685	COG2226	methyltransferase
IXO704_RS18690	COG0066	3-isopropylmalate dehydratase activity
IXO704_RS18695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO704_RS18725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO704_RS18730	COG1538	Outer membrane efflux protein
IXO704_RS18735	COG1519	Transferase
IXO704_RS18740	COG1560	Kdo2-lipid A biosynthetic process
IXO704_RS18795	COG0308	aminopeptidase N
IXO704_RS18800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO704_RS18810	COG0330	HflC and HflK could
IXO704_RS18815	COG0330	HflC and HflK could
IXO704_RS18835	COG0678	peroxiredoxin activity
IXO704_RS18845	COG2826	transposase and inactivated derivatives, IS30 family
IXO704_RS18875	COG3039	Transposase
IXO704_RS18910	COG3829	transcription factor binding
IXO704_RS18945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO704_RS18950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO704_RS18960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO704_RS18965	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS18990	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO704_RS19010	COG3039	Transposase
IXO704_RS19050	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO704_RS19090	COG3039	Transposase
IXO704_RS19100	COG2188	Transcriptional regulator
IXO704_RS19115	COG1450	Type ii and iii secretion system protein
IXO704_RS19130	COG3166	PFAM Fimbrial assembly family protein
IXO704_RS19135	COG3156	type II secretion system protein K
IXO704_RS19140	COG4795	General secretion pathway protein
IXO704_RS19145	COG2165	general secretion pathway protein
IXO704_RS19150	COG4970	Tfp pilus assembly protein FimT
IXO704_RS19155	COG2165	general secretion pathway protein
IXO704_RS19160	COG1459	type II secretion system
IXO704_RS19170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO704_RS19180	COG5295	Hep Hag repeat protein
IXO704_RS19185	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO704_RS19185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO704_RS19190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO704_RS19195	COG4974	Belongs to the 'phage' integrase family
IXO704_RS19205	COG0795	lipopolysaccharide-transporting ATPase activity
IXO704_RS19215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO704_RS19230	COG0525	valine-tRNA ligase activity
IXO704_RS19265	COG3039	Transposase
IXO704_RS19300	COG3039	Transposase
IXO704_RS19330	COG1183	phosphatidylcholine synthase activity
IXO704_RS19340	COG0442	prolyl-tRNA aminoacylation
IXO704_RS19355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO704_RS19360	COG1127	ABC transporter
IXO704_RS19365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO704_RS19365	COG3218	ABC-type transport auxiliary lipoprotein component
IXO704_RS19400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO704_RS19405	COG0662	Cupin 2, conserved barrel domain protein
IXO704_RS19405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO704_RS19430	COG2086	electron transfer activity
IXO704_RS19455	COG3328	transposase activity
IXO704_RS19495	COG0626	cystathionine gamma-synthase activity
IXO704_RS19525	COG0625	glutathione transferase activity
IXO704_RS19540	COG0513	Belongs to the DEAD box helicase family
IXO704_RS19545	COG0720	synthase
IXO704_RS19555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO704_RS19560	COG1956	GAF domain-containing protein
IXO704_RS19595	COG0339	signal peptide processing
IXO704_RS19645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO704_RS19650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO704_RS19700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO704_RS19705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO704_RS19710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO704_RS19715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO704_RS19725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO704_RS19735	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO704_RS19755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO704_RS19765	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO704_RS19795	COG2011	ABC-type metal ion transport system permease component
IXO704_RS19805	COG0697	spore germination
IXO704_RS19840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO704_RS19845	COG1187	pseudouridine synthase activity
IXO704_RS19850	COG2813	Specifically methylates the guanine in position
IXO704_RS19880	COG2205	protein histidine kinase activity
IXO704_RS19880	COG2202	Pas domain
IXO704_RS19905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO704_RS19955	COG0745	RESPONSE REGULATOR receiver
IXO704_RS19970	COG1404	Belongs to the peptidase S8 family
IXO704_RS19990	COG0842	Transport permease protein
IXO704_RS19995	COG1131	(ABC) transporter
IXO704_RS20000	COG0025	NhaP-type Na H and K H
IXO704_RS20015	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO704_RS20025	COG1573	uracil-dna glycosylase
IXO704_RS20035	COG3384	dioxygenase
IXO704_RS20050	COG0667	Aldo Keto reductase
IXO704_RS20065	COG3590	peptidase
IXO704_RS20085	COG0531	amino acid
IXO704_RS20110	COG2972	Histidine kinase
IXO704_RS20160	COG1271	oxidase subunit
IXO704_RS20320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO704_RS20330	COG1560	Kdo2-lipid A biosynthetic process
IXO704_RS20380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO704_RS20380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO704_RS20385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO704_RS20390	COG0242	peptide deformylase activity
IXO704_RS20395	COG1652	LysM domain
IXO704_RS20400	COG0758	DNA mediated transformation
IXO704_RS20405	COG2922	Belongs to the Smg family
IXO704_RS20420	COG1754	DNA topoisomerase type I activity
IXO704_RS20420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO704_RS20425	COG0009	L-threonylcarbamoyladenylate synthase
IXO704_RS20440	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS20450	COG0616	signal peptide processing
IXO704_RS20455	COG0534	Mate efflux family protein
IXO704_RS20480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO704_RS20515	COG1324	tolerance protein
IXO704_RS20525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO704_RS20530	COG0511	ligase activity, forming carbon-carbon bonds
IXO704_RS20540	COG0439	Biotin carboxylase
IXO704_RS20585	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO704_RS20650	COG3039	Transposase
IXO704_RS20675	COG3039	Transposase
IXO704_RS20750	COG3210	domain, Protein
IXO704_RS20755	COG2831	hemolysin activation secretion protein
IXO704_RS20785	COG2267	carboxylic ester hydrolase activity
IXO704_RS20790	COG2267	carboxylic ester hydrolase activity
IXO704_RS20795	COG2267	carboxylic ester hydrolase activity
IXO704_RS20805	COG0138	bifunctional purine biosynthesis protein purh
IXO704_RS20815	COG0151	Belongs to the GarS family
IXO704_RS20840	COG1289	transmembrane transporter activity
IXO704_RS20855	COG2814	Major facilitator Superfamily
IXO704_RS20870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO704_RS20905	COG0745	RESPONSE REGULATOR receiver
IXO704_RS20950	COG0739	heme binding
IXO704_RS20965	COG2211	Major facilitator Superfamily
IXO704_RS20970	COG0708	Exodeoxyribonuclease III
IXO704_RS20985	COG1192	Involved in chromosome partitioning
IXO704_RS20990	COG1475	DNA binding
IXO704_RS21005	COG0463	Glycosyl transferase, family 2
IXO704_RS21030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO704_RS21040	COG0018	arginyl-trna synthetase
IXO704_RS21055	COG4221	oxidoreductase activity
IXO704_RS21080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO704_RS21085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO704_RS21100	COG3485	protocatechuate 3,4-dioxygenase
IXO704_RS21105	COG3485	protocatechuate 3,4-dioxygenase
IXO704_RS21140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO704_RS21145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO704_RS21155	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO704_RS21155	COG1042	CoA-binding domain protein
IXO704_RS21155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO704_RS21170	COG2239	Acts as a magnesium transporter
IXO704_RS21185	COG3039	Transposase
IXO704_RS21195	COG3328	transposase activity
IXO704_RS21205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO704_RS21205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO704_RS21215	COG1473	amidohydrolase
IXO704_RS21220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO704_RS21225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO704_RS21240	COG5383	Protein conserved in bacteria
IXO704_RS21265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO704_RS21270	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO704_RS21285	COG0028	Belongs to the TPP enzyme family
IXO704_RS21290	COG4191	Histidine kinase
IXO704_RS21315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO704_RS21330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO704_RS21335	COG3177	Filamentation induced by cAMP protein fic
IXO704_RS21350	COG0596	Alpha beta hydrolase
IXO704_RS21355	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO704_RS21360	COG0318	PFAM AMP-dependent synthetase and ligase
IXO704_RS21365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO704_RS21415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO704_RS21425	COG0129	dihydroxy-acid dehydratase activity
IXO704_RS21445	COG3039	Transposase
IXO704_RS21455	COG0408	coproporphyrinogen oxidase activity
IXO704_RS21495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO704_RS21515	COG2201	protein-glutamate methylesterase activity
IXO704_RS21555	COG2353	YceI-like domain
IXO704_RS21585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO704_RS21600	COG3386	PFAM SMP-30 Gluconolaconase
IXO704_RS21645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO704_RS21665	COG0459	protein refolding
IXO704_RS21690	COG1252	NADH dehydrogenase
IXO704_RS21700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO704_RS21705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO704_RS21710	COG2201	protein-glutamate methylesterase activity
IXO704_RS21715	COG2177	Part of the ABC transporter FtsEX involved in
IXO704_RS21720	COG2884	Cell division ATP-binding protein ftsE
IXO704_RS21730	COG3118	belongs to the thioredoxin family
IXO704_RS21735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO704_RS21750	COG0729	surface antigen
IXO704_RS21755	COG2911	Protein conserved in bacteria
IXO704_RS21790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO704_RS21805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO704_RS21855	COG1733	regulation of RNA biosynthetic process
IXO704_RS21860	COG0702	epimerase
IXO704_RS21890	COG0583	DNA-binding transcription factor activity
IXO704_RS21895	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO704_RS21915	COG0745	RESPONSE REGULATOR receiver
IXO704_RS21945	COG1902	pentaerythritol trinitrate reductase activity
IXO704_RS21950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO704_RS21960	COG2814	Major facilitator Superfamily
IXO704_RS21965	COG0583	DNA-binding transcription factor activity
IXO704_RS21980	COG0084	hydrolase, TatD family'
IXO704_RS22025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO704_RS22045	COG2072	flavoprotein involved in K transport
IXO704_RS22100	COG4770	biotin carboxylase activity
IXO704_RS22105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO704_RS22110	COG1960	acyl-CoA dehydrogenase activity
IXO704_RS22165	COG0523	cobalamin synthesis protein
IXO704_RS22175	COG0697	spore germination
IXO704_RS22185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO704_RS22200	COG4771	TonB-dependent receptor
IXO704_RS22205	COG0457	Tetratricopeptide repeat
IXO704_RS22215	COG0752	glycyl-tRNA synthetase alpha subunit
IXO704_RS22220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO704_RS22235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO704_RS22235	COG0519	Catalyzes the synthesis of GMP from XMP
IXO704_RS22245	COG0805	protein transport
IXO704_RS22255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO704_RS22265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO704_RS22290	COG2974	May be involved in recombination
IXO704_RS22295	COG0037	tRNA processing
IXO704_RS22310	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO704_RS22320	COG4948	Mandelate Racemase Muconate Lactonizing
IXO704_RS22330	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO704_RS22335	COG0246	Mannitol dehydrogenase
IXO704_RS22360	COG3693	PFAM glycoside hydrolase, family 10
IXO704_RS22380	COG2211	Major facilitator Superfamily
IXO704_RS22430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO704_RS22470	COG1846	Transcriptional regulator
IXO704_RS22475	COG1764	response to oxidative stress
IXO704_RS22550	COG3549	Plasmid maintenance system killer
IXO704_RS22560	COG1074	ATP-dependent DNA helicase activity
IXO704_RS22565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO704_RS22610	COG2032	superoxide dismutase activity
IXO704_RS22615	COG2032	superoxide dismutase activity
IXO704_RS22620	COG2204	response regulator
IXO704_RS22625	COG3852	Histidine kinase
IXO704_RS22630	COG0004	ammonium transporteR
IXO704_RS22635	COG0347	Belongs to the P(II) protein family
IXO704_RS22640	COG0174	glutamine synthetase
IXO704_RS22645	COG1968	undecaprenyl-diphosphatase activity
IXO704_RS22690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO704_RS22700	COG2062	phosphohistidine phosphatase, SixA
IXO704_RS22705	COG0489	protein tyrosine kinase activity
IXO704_RS22725	COG1396	sequence-specific DNA binding
IXO704_RS22730	COG3550	peptidyl-serine autophosphorylation
IXO704_RS22735	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO704_RS22740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO704_RS22755	COG0517	IMP dehydrogenase activity
IXO704_RS22755	COG1125	glycine betaine transport
IXO704_RS22770	COG1119	ATPase activity
IXO704_RS22780	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO704_RS22795	COG3039	Transposase
IXO704_RS22820	COG0656	L-ascorbic acid biosynthetic process
IXO704_RS22825	COG2130	NADP-dependent
IXO704_RS22830	COG0667	Aldo Keto reductase
IXO704_RS22840	COG1187	pseudouridine synthase activity
IXO704_RS22850	COG1643	Atp-dependent helicase
IXO704_RS22855	COG4807	Protein conserved in bacteria
IXO704_RS22860	COG4948	Mandelate Racemase Muconate Lactonizing
IXO704_RS22865	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO704_RS22870	COG1028	Short-chain dehydrogenase reductase Sdr
IXO704_RS22890	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO704_RS22930	COG3162	membrane
IXO704_RS22935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO704_RS22955	COG0708	Exodeoxyribonuclease III
IXO704_RS22970	COG2091	lysine biosynthetic process via aminoadipic acid
IXO704_RS22980	COG3540	Alkaline phosphatase
IXO704_RS22985	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO704_RS23010	COG2159	amidohydrolase
IXO704_RS23020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO704_RS23025	COG0583	DNA-binding transcription factor activity
IXO704_RS23030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO704_RS23045	COG0210	DNA helicase
IXO704_RS23070	COG0531	amino acid
IXO704_RS23075	COG1322	Protein conserved in bacteria
IXO704_RS23085	COG0386	Belongs to the glutathione peroxidase family
IXO704_RS23145	COG0793	Belongs to the peptidase S41A family
IXO704_RS23150	COG4942	peptidase
IXO704_RS23160	COG2234	aminopeptidase activity
IXO704_RS23205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO704_RS23210	COG0302	gtp cyclohydrolase
IXO704_RS23230	COG0477	Major facilitator Superfamily
IXO704_RS23345	COG3039	Transposase
IXO704_RS23355	COG1929	Belongs to the glycerate kinase type-1 family
IXO704_RS23360	COG2271	Major facilitator Superfamily
IXO704_RS23375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO704_RS23380	COG0861	Integral membrane protein TerC family
IXO704_RS23395	COG0584	glycerophosphoryl diester phosphodiesterase
IXO704_RS23405	COG0671	phosphoesterase, PA-phosphatase related
IXO704_RS23415	COG0726	polysaccharide deacetylase
IXO704_RS23420	COG0706	membrane insertase activity