locus-tag	class	description
BRM77_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRM77_RS00030	COG0187	DNA topoisomerase II activity
BRM77_RS00040	COG0501	Belongs to the peptidase M48B family
BRM77_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM77_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRM77_RS00100	COG4772	TonB-dependent receptor
BRM77_RS00115	COG3039	Transposase
BRM77_RS00120	COG1304	FMN binding
BRM77_RS00125	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRM77_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM77_RS00160	COG3039	Transposase
BRM77_RS00165	COG1136	(ABC) transporter
BRM77_RS00215	COG3039	Transposase
BRM77_RS00225	COG0513	Belongs to the DEAD box helicase family
BRM77_RS00330	COG1858	cytochrome C peroxidase
BRM77_RS00340	COG0702	epimerase
BRM77_RS00365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRM77_RS00385	COG1649	PFAM Uncharacterised BCR, COG1649
BRM77_RS00390	COG2354	Protein conserved in bacteria
BRM77_RS00400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM77_RS00415	COG1511	domain protein
BRM77_RS00415	COG3264	Mechanosensitive ion channel
BRM77_RS00495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRM77_RS00575	COG3039	Transposase
BRM77_RS00585	COG3039	Transposase
BRM77_RS00620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM77_RS00630	COG0642	Histidine kinase
BRM77_RS00640	COG1090	epimerase
BRM77_RS00650	COG3039	Transposase
BRM77_RS00675	COG2826	transposase and inactivated derivatives, IS30 family
BRM77_RS00735	COG1136	(ABC) transporter
BRM77_RS00780	COG1272	protein, Hemolysin III
BRM77_RS00785	COG1205	dead DEAH box helicase
BRM77_RS00785	COG1111	helicase
BRM77_RS00845	COG0070	glutamate synthase
BRM77_RS00845	COG0069	glutamate synthase activity
BRM77_RS00845	COG0067	glutamate synthase
BRM77_RS00850	COG0493	'glutamate synthase
BRM77_RS00890	COG1609	Transcriptional regulator
BRM77_RS00925	COG0366	Alpha amylase catalytic
BRM77_RS00930	COG0366	Alpha amylase catalytic
BRM77_RS00985	COG0606	chelatase, subunit chli
BRM77_RS01030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRM77_RS01035	COG1166	arginine decarboxylase activity
BRM77_RS01100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM77_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS01150	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRM77_RS01165	COG0210	DNA helicase
BRM77_RS01180	COG3132	Protein of unknown function, DUF480
BRM77_RS01185	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRM77_RS01190	COG0284	orotidine-5'-phosphate decarboxylase activity
BRM77_RS01225	COG2937	Belongs to the GPAT DAPAT family
BRM77_RS01255	COG2755	lipolytic protein G-D-S-L family
BRM77_RS01270	COG3186	Phenylalanine-4-hydroxylase
BRM77_RS01275	COG1522	sequence-specific DNA binding
BRM77_RS01320	COG1064	alcohol dehydrogenase
BRM77_RS01330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM77_RS01340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM77_RS01350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM77_RS01375	COG3039	Transposase
BRM77_RS01380	COG0676	glucose-6-phosphate 1-epimerase activity
BRM77_RS01445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRM77_RS01470	COG2853	Lipoprotein
BRM77_RS01485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM77_RS01490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM77_RS01495	COG1127	ABC transporter
BRM77_RS01530	COG3039	Transposase
BRM77_RS01580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM77_RS01595	COG3265	gluconokinase activity
BRM77_RS01600	COG2211	Major facilitator Superfamily
BRM77_RS01605	COG3459	Glycosyltransferase 36 associated
BRM77_RS01620	COG2205	protein histidine kinase activity
BRM77_RS01630	COG1414	Transcriptional regulator
BRM77_RS01635	COG0738	Major facilitator superfamily
BRM77_RS01640	COG3254	rhamnose metabolic process
BRM77_RS01670	COG0339	signal peptide processing
BRM77_RS01700	COG0564	pseudouridine synthase activity
BRM77_RS01710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM77_RS01810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRM77_RS01820	COG0842	Transport permease protein
BRM77_RS01825	COG1131	(ABC) transporter
BRM77_RS01830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM77_RS01850	COG1476	TRANSCRIPTIONal
BRM77_RS01860	COG4555	ABC transporter
BRM77_RS01900	COG0625	glutathione transferase activity
BRM77_RS01950	COG0583	DNA-binding transcription factor activity
BRM77_RS01985	COG1199	ATP-dependent helicase activity
BRM77_RS02005	COG1566	PFAM secretion protein HlyD family protein
BRM77_RS02035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM77_RS02075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRM77_RS02075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRM77_RS02080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRM77_RS02095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRM77_RS02135	COG3237	CsbD-like
BRM77_RS02140	COG0180	Tryptophanyl-tRNA synthetase
BRM77_RS02145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM77_RS02195	COG0753	catalase activity
BRM77_RS02200	COG1595	DNA-templated transcription, initiation
BRM77_RS02210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM77_RS02220	COG0628	permease
BRM77_RS02235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRM77_RS02240	COG1040	competence protein
BRM77_RS02245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRM77_RS02250	COG0156	8-amino-7-oxononanoate synthase activity
BRM77_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS02280	COG0463	Glycosyl transferase, family 2
BRM77_RS02290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRM77_RS02295	COG3100	YcgL domain-containing protein
BRM77_RS02315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM77_RS02335	COG2239	Acts as a magnesium transporter
BRM77_RS02345	COG1042	CoA-binding domain protein
BRM77_RS02345	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM77_RS02345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRM77_RS02355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM77_RS02365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM77_RS02400	COG3485	protocatechuate 3,4-dioxygenase
BRM77_RS02405	COG3485	protocatechuate 3,4-dioxygenase
BRM77_RS02420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM77_RS02425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRM77_RS02455	COG4221	oxidoreductase activity
BRM77_RS02475	COG2003	Belongs to the UPF0758 family
BRM77_RS02480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRM77_RS02505	COG0463	Glycosyl transferase, family 2
BRM77_RS02520	COG1475	DNA binding
BRM77_RS02525	COG1192	Involved in chromosome partitioning
BRM77_RS02540	COG0708	Exodeoxyribonuclease III
BRM77_RS02545	COG2211	Major facilitator Superfamily
BRM77_RS02560	COG0739	heme binding
BRM77_RS02610	COG0745	RESPONSE REGULATOR receiver
BRM77_RS02650	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRM77_RS02675	COG2814	Major facilitator Superfamily
BRM77_RS02690	COG1289	transmembrane transporter activity
BRM77_RS02700	COG1136	(ABC) transporter
BRM77_RS02700	COG0577	efflux transmembrane transporter activity
BRM77_RS02705	COG0151	Belongs to the GarS family
BRM77_RS02715	COG0419	ATPase involved in DNA repair
BRM77_RS02730	COG2267	carboxylic ester hydrolase activity
BRM77_RS02740	COG2267	carboxylic ester hydrolase activity
BRM77_RS02745	COG2453	phosphatase
BRM77_RS02745	COG0671	phosphoesterase, PA-phosphatase related
BRM77_RS02760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRM77_RS02820	COG0439	Biotin carboxylase
BRM77_RS02830	COG0511	ligase activity, forming carbon-carbon bonds
BRM77_RS02835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRM77_RS02855	COG1324	tolerance protein
BRM77_RS02890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRM77_RS02920	COG0534	Mate efflux family protein
BRM77_RS02925	COG0616	signal peptide processing
BRM77_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS02950	COG0009	L-threonylcarbamoyladenylate synthase
BRM77_RS02955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRM77_RS02955	COG1754	DNA topoisomerase type I activity
BRM77_RS02970	COG2922	Belongs to the Smg family
BRM77_RS02975	COG0758	DNA mediated transformation
BRM77_RS02980	COG1652	LysM domain
BRM77_RS02985	COG0242	peptide deformylase activity
BRM77_RS02990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRM77_RS02995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRM77_RS02995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM77_RS03045	COG1560	Kdo2-lipid A biosynthetic process
BRM77_RS03055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM77_RS03215	COG1294	oxidase, subunit
BRM77_RS03220	COG1271	oxidase subunit
BRM77_RS03235	COG2204	response regulator
BRM77_RS03265	COG2972	Histidine kinase
BRM77_RS03280	COG0531	amino acid
BRM77_RS03300	COG3590	peptidase
BRM77_RS03315	COG0667	Aldo Keto reductase
BRM77_RS03330	COG3384	dioxygenase
BRM77_RS03340	COG1573	uracil-dna glycosylase
BRM77_RS03350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRM77_RS03365	COG0025	NhaP-type Na H and K H
BRM77_RS03370	COG1131	(ABC) transporter
BRM77_RS03375	COG0842	Transport permease protein
BRM77_RS03390	COG1404	Belongs to the peptidase S8 family
BRM77_RS03405	COG0745	RESPONSE REGULATOR receiver
BRM77_RS03455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM77_RS03480	COG2202	Pas domain
BRM77_RS03480	COG2205	protein histidine kinase activity
BRM77_RS03515	COG2813	Specifically methylates the guanine in position
BRM77_RS03520	COG1187	pseudouridine synthase activity
BRM77_RS03525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRM77_RS03560	COG0697	spore germination
BRM77_RS03570	COG2011	ABC-type metal ion transport system permease component
BRM77_RS03600	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRM77_RS03610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRM77_RS03630	COG0356	it plays a direct role in the translocation of protons across the membrane
BRM77_RS03640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRM77_RS03650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRM77_RS03655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRM77_RS03660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRM77_RS03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM77_RS03725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM77_RS03760	COG3039	Transposase
BRM77_RS03785	COG0339	signal peptide processing
BRM77_RS03825	COG1956	GAF domain-containing protein
BRM77_RS03830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRM77_RS03840	COG0720	synthase
BRM77_RS03850	COG0513	Belongs to the DEAD box helicase family
BRM77_RS03895	COG0626	cystathionine gamma-synthase activity
BRM77_RS03945	COG3328	transposase activity
BRM77_RS03970	COG2086	electron transfer activity
BRM77_RS03995	COG0662	Cupin 2, conserved barrel domain protein
BRM77_RS03995	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRM77_RS04000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM77_RS04040	COG3218	ABC-type transport auxiliary lipoprotein component
BRM77_RS04040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM77_RS04045	COG1127	ABC transporter
BRM77_RS04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM77_RS04065	COG0442	prolyl-tRNA aminoacylation
BRM77_RS04075	COG1183	phosphatidylcholine synthase activity
BRM77_RS04105	COG3039	Transposase
BRM77_RS04175	COG0525	valine-tRNA ligase activity
BRM77_RS04190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM77_RS04200	COG0795	lipopolysaccharide-transporting ATPase activity
BRM77_RS04210	COG3039	Transposase
BRM77_RS04225	COG4974	Belongs to the 'phage' integrase family
BRM77_RS04230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRM77_RS04235	COG0047	phosphoribosylformylglycinamidine synthase activity
BRM77_RS04235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRM77_RS04245	COG5295	Hep Hag repeat protein
BRM77_RS04265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM77_RS04275	COG1459	type II secretion system
BRM77_RS04280	COG2165	general secretion pathway protein
BRM77_RS04285	COG4970	Tfp pilus assembly protein FimT
BRM77_RS04290	COG2165	general secretion pathway protein
BRM77_RS04295	COG4795	General secretion pathway protein
BRM77_RS04300	COG3156	type II secretion system protein K
BRM77_RS04305	COG3166	PFAM Fimbrial assembly family protein
BRM77_RS04320	COG1450	Type ii and iii secretion system protein
BRM77_RS04335	COG2188	Transcriptional regulator
BRM77_RS04390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRM77_RS04395	COG1518	maintenance of DNA repeat elements
BRM77_RS04440	COG1399	metal-binding, possibly nucleic acid-binding protein
BRM77_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS04470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM77_RS04480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRM77_RS04485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRM77_RS04520	COG3829	transcription factor binding
BRM77_RS04555	COG3039	Transposase
BRM77_RS04610	COG2826	transposase and inactivated derivatives, IS30 family
BRM77_RS04620	COG0678	peroxiredoxin activity
BRM77_RS04640	COG0330	HflC and HflK could
BRM77_RS04645	COG0330	HflC and HflK could
BRM77_RS04660	COG0308	aminopeptidase N
BRM77_RS04710	COG1560	Kdo2-lipid A biosynthetic process
BRM77_RS04715	COG1519	Transferase
BRM77_RS04720	COG1538	Outer membrane efflux protein
BRM77_RS04725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM77_RS04750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRM77_RS04755	COG0066	3-isopropylmalate dehydratase activity
BRM77_RS04790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRM77_RS04800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRM77_RS04805	COG3710	Transcriptional regulator
BRM77_RS04830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRM77_RS04850	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRM77_RS04880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM77_RS04890	COG3781	membrane
BRM77_RS04910	COG0625	glutathione transferase activity
BRM77_RS04920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRM77_RS04925	COG1217	gtp-binding protein TYPA
BRM77_RS04945	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRM77_RS05080	COG3039	Transposase
BRM77_RS05105	COG0584	glycerophosphoryl diester phosphodiesterase
BRM77_RS05130	COG0473	3-isopropylmalate dehydrogenase activity
BRM77_RS05185	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRM77_RS05225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRM77_RS05250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM77_RS05260	COG0631	protein serine/threonine phosphatase activity
BRM77_RS05345	COG0582	viral genome integration into host DNA
BRM77_RS05355	COG0859	PFAM glycosyl transferase family 9
BRM77_RS05360	COG3642	lipopolysaccharide core region biosynthetic process
BRM77_RS05365	COG1234	tRNA 3'-trailer cleavage
BRM77_RS05370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRM77_RS05380	COG0315	cyclic pyranopterin monophosphate synthase activity
BRM77_RS05385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRM77_RS05390	COG0314	molybdopterin synthase activity
BRM77_RS05420	COG0537	adenosine 5'-monophosphoramidase activity
BRM77_RS05440	COG0714	Associated with various cellular activities
BRM77_RS05460	COG0242	peptide deformylase activity
BRM77_RS05510	COG3039	Transposase
BRM77_RS05540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM77_RS05545	COG0726	polysaccharide deacetylase
BRM77_RS05595	COG2211	Major facilitator Superfamily
BRM77_RS05605	COG1609	Transcriptional regulator
BRM77_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS05615	COG2851	Citrate transporter
BRM77_RS05635	COG0642	Histidine kinase
BRM77_RS05645	COG2197	response regulator
BRM77_RS05665	COG0583	DNA-binding transcription factor activity
BRM77_RS05680	COG4191	Histidine kinase
BRM77_RS05700	COG0281	malic enzyme
BRM77_RS05700	COG0280	phosphate acetyltransferase
BRM77_RS05735	COG0352	thiamine-phosphate diphosphorylase activity
BRM77_RS05740	COG1773	rubredoxin
BRM77_RS05745	COG2912	Transglutaminase-like superfamily
BRM77_RS05765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRM77_RS05790	COG0006	proline dipeptidase activity
BRM77_RS05825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRM77_RS05840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRM77_RS05845	COG1561	YicC-like family, N-terminal region
BRM77_RS05870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM77_RS05880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRM77_RS05905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRM77_RS05955	COG0714	Associated with various cellular activities
BRM77_RS05975	COG2304	oxidoreductase activity
BRM77_RS05995	COG1301	dicarboxylic acid transport
BRM77_RS06000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRM77_RS06010	COG0739	heme binding
BRM77_RS06015	COG1376	ErfK ybiS ycfS ynhG family protein
BRM77_RS06040	COG1022	Amp-dependent synthetase and ligase
BRM77_RS06050	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS06065	COG0642	Histidine kinase
BRM77_RS06085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRM77_RS06090	COG4149	molybdate abc transporter
BRM77_RS06095	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRM77_RS06100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM77_RS06100	COG3453	Protein conserved in bacteria
BRM77_RS06135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRM77_RS06155	COG2205	protein histidine kinase activity
BRM77_RS06160	COG0745	RESPONSE REGULATOR receiver
BRM77_RS06210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM77_RS06215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRM77_RS06325	COG2201	protein-glutamate methylesterase activity
BRM77_RS06355	COG0653	protein targeting
BRM77_RS06360	COG3039	Transposase
BRM77_RS06585	COG2201	protein-glutamate methylesterase activity
BRM77_RS06595	COG2801	Transposase and inactivated derivatives
BRM77_RS06610	COG3039	Transposase
BRM77_RS06635	COG3328	transposase activity
BRM77_RS06670	COG0322	excinuclease ABC activity
BRM77_RS06680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRM77_RS06690	COG1663	tetraacyldisaccharide 4'-kinase activity
BRM77_RS06705	COG0811	peptide transport
BRM77_RS06735	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRM77_RS06750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRM77_RS06765	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRM77_RS06780	COG0354	folic acid binding
BRM77_RS06795	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM77_RS06805	COG0363	glucosamine-6-phosphate deaminase activity
BRM77_RS06810	COG0129	dihydroxy-acid dehydratase activity
BRM77_RS06815	COG0800	Aldolase
BRM77_RS06845	COG5002	protein histidine kinase activity
BRM77_RS06845	COG2205	protein histidine kinase activity
BRM77_RS06845	COG0784	Response regulator, receiver
BRM77_RS06925	COG0386	Belongs to the glutathione peroxidase family
BRM77_RS07015	COG5001	Diguanylate cyclase
BRM77_RS07015	COG2203	Gaf domain
BRM77_RS07015	COG3706	GGDEF domain
BRM77_RS07015	COG4251	negative regulation of phosphorylation
BRM77_RS07035	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM77_RS07085	COG0617	tRNA 3'-terminal CCA addition
BRM77_RS07095	COG1469	GTP cyclohydrolase I activity
BRM77_RS07100	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM77_RS07150	COG4566	intracellular signal transduction
BRM77_RS07190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRM77_RS07195	COG1605	Chorismate mutase
BRM77_RS07195	COG0077	Prephenate dehydratase
BRM77_RS07205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRM77_RS07250	COG1228	amidohydrolase
BRM77_RS07255	COG2986	histidine ammonia-lyase
BRM77_RS07265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRM77_RS07290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRM77_RS07305	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRM77_RS07320	COG3115	cell septum assembly
BRM77_RS07330	COG0359	binds to the 23S rRNA
BRM77_RS07340	COG0360	Binds together with S18 to 16S ribosomal RNA
BRM77_RS07345	COG0316	Belongs to the HesB IscA family
BRM77_RS07380	COG0288	reversible hydration of carbon dioxide
BRM77_RS07405	COG2925	Exonuclease
BRM77_RS07415	COG0667	Aldo Keto reductase
BRM77_RS07440	COG0116	Belongs to the methyltransferase superfamily
BRM77_RS07440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM77_RS07485	COG0494	nUDIX hydrolase
BRM77_RS07495	COG1024	Enoyl-CoA hydratase
BRM77_RS07505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRM77_RS07520	COG3039	Transposase
BRM77_RS07560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRM77_RS07565	COG0573	inorganic phosphate transmembrane transporter activity
BRM77_RS07580	COG0704	Plays a role in the regulation of phosphate uptake
BRM77_RS07590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM77_RS07605	COG3328	transposase activity
BRM77_RS07640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM77_RS07645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM77_RS07650	COG1862	Preprotein translocase
BRM77_RS07655	COG0343	queuine tRNA-ribosyltransferase activity
BRM77_RS07745	COG0405	Gamma-glutamyltransferase
BRM77_RS07750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRM77_RS07765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRM77_RS07770	COG0742	ribosomal rna small subunit methyltransferase
BRM77_RS07790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRM77_RS07820	COG3039	Transposase
BRM77_RS07830	COG3039	Transposase
BRM77_RS07860	COG0303	'Molybdopterin
BRM77_RS07870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM77_RS07880	COG1426	Protein conserved in bacteria
BRM77_RS07890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRM77_RS07905	COG1024	Enoyl-CoA hydratase
BRM77_RS07905	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM77_RS07910	COG0183	Belongs to the thiolase family
BRM77_RS07915	COG0038	chloride channel
BRM77_RS07935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRM77_RS07960	COG1674	ftsk spoiiie
BRM77_RS07965	COG0492	ferredoxin-NADP+ reductase activity
BRM77_RS07990	COG0542	response to heat
BRM77_RS08005	COG0482	sulfurtransferase activity
BRM77_RS08030	COG5001	Diguanylate cyclase
BRM77_RS08035	COG4585	Histidine kinase
BRM77_RS08045	COG5002	protein histidine kinase activity
BRM77_RS08065	COG0835	chemotaxis
BRM77_RS08065	COG0784	Response regulator, receiver
BRM77_RS08075	COG1558	bacterial-type flagellum-dependent cell motility
BRM77_RS08080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRM77_RS08090	COG4787	bacterial-type flagellum-dependent cell motility
BRM77_RS08130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRM77_RS08135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRM77_RS08165	COG2201	protein-glutamate methylesterase activity
BRM77_RS08185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM77_RS08195	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS08230	COG1677	Flagellar hook-basal body complex protein FliE
BRM77_RS08280	COG3190	flagellar
BRM77_RS08300	COG1684	flagellar biosynthetic protein fliR
BRM77_RS08355	COG2198	Histidine kinase
BRM77_RS08355	COG0784	Response regulator, receiver
BRM77_RS08355	COG0643	Histidine kinase
BRM77_RS08395	COG3039	Transposase
BRM77_RS08490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRM77_RS08495	COG4988	ABC transporter
BRM77_RS08520	COG1271	oxidase subunit
BRM77_RS08555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRM77_RS08575	COG0165	Argininosuccinate lyase
BRM77_RS08590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRM77_RS08595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM77_RS08605	COG0137	argininosuccinate synthase activity
BRM77_RS08610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRM77_RS08625	COG2166	iron-sulfur cluster assembly
BRM77_RS08650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRM77_RS08690	COG3039	Transposase
BRM77_RS08705	COG4677	pectinesterase activity
BRM77_RS08735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRM77_RS08740	COG0402	S-adenosylhomocysteine deaminase activity
BRM77_RS08755	COG1509	lysine 2,3-aminomutase activity
BRM77_RS08760	COG3300	MHYT domain
BRM77_RS08760	COG5001	Diguanylate cyclase
BRM77_RS08775	COG0483	inositol monophosphate 1-phosphatase activity
BRM77_RS08780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM77_RS08805	COG0488	(ABC) transporter
BRM77_RS08810	COG0513	Belongs to the DEAD box helicase family
BRM77_RS08830	COG0625	glutathione transferase activity
BRM77_RS08840	COG1671	Belongs to the UPF0178 family
BRM77_RS08845	COG4681	YaeQ
BRM77_RS08850	COG2081	HI0933 family
BRM77_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS08895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRM77_RS08900	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM77_RS08905	COG0802	atpase or kinase
BRM77_RS08910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRM77_RS08910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRM77_RS08915	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM77_RS08940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM77_RS09025	COG3328	transposase activity
BRM77_RS09070	COG2969	positive regulation of protein catabolic process
BRM77_RS09075	COG0625	glutathione transferase activity
BRM77_RS09080	COG2857	Cytochrome c1
BRM77_RS09085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRM77_RS09090	COG0723	plastoquinol--plastocyanin reductase activity
BRM77_RS09100	COG0741	lytic transglycosylase activity
BRM77_RS09125	COG1702	phosphate starvation-inducible protein PhoH
BRM77_RS09145	COG4535	Mg2 and Co2 transporter CorC
BRM77_RS09160	COG1012	belongs to the aldehyde dehydrogenase family
BRM77_RS09170	COG1177	transmembrane transport
BRM77_RS09180	COG3842	ATPase activity
BRM77_RS09220	COG0174	glutamine synthetase
BRM77_RS09225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM77_RS09235	COG0477	Major facilitator Superfamily
BRM77_RS09245	COG0243	molybdopterin cofactor binding
BRM77_RS09255	COG2223	nitrite transmembrane transporter activity
BRM77_RS09275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRM77_RS09280	COG1121	(ABC) transporter
BRM77_RS09290	COG2733	membrane
BRM77_RS09295	COG0784	Response regulator, receiver
BRM77_RS09295	COG5002	protein histidine kinase activity
BRM77_RS09295	COG2205	protein histidine kinase activity
BRM77_RS09305	COG3039	Transposase
BRM77_RS09315	COG2902	Dehydrogenase
BRM77_RS09325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM77_RS09330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM77_RS09350	COG1609	Transcriptional regulator
BRM77_RS09355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM77_RS09355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM77_RS09360	COG1105	Belongs to the carbohydrate kinase PfkB family
BRM77_RS09365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM77_RS09365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM77_RS09380	COG3039	Transposase
BRM77_RS09500	COG3039	Transposase
BRM77_RS09530	COG4771	TonB-dependent receptor
BRM77_RS09540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM77_RS09560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRM77_RS09565	COG1360	Flagellar Motor Protein
BRM77_RS09575	COG0835	chemotaxis
BRM77_RS09585	COG0745	RESPONSE REGULATOR receiver
BRM77_RS09610	COG0840	transmembrane signaling receptor activity
BRM77_RS09625	COG0840	transmembrane signaling receptor activity
BRM77_RS09635	COG0840	transmembrane signaling receptor activity
BRM77_RS09645	COG0840	transmembrane signaling receptor activity
BRM77_RS09650	COG0840	transmembrane signaling receptor activity
BRM77_RS09655	COG0840	transmembrane signaling receptor activity
BRM77_RS09660	COG0840	transmembrane signaling receptor activity
BRM77_RS09680	COG0835	chemotaxis
BRM77_RS09705	COG0840	transmembrane signaling receptor activity
BRM77_RS09740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM77_RS09770	COG0318	PFAM AMP-dependent synthetase and ligase
BRM77_RS09775	COG1024	Enoyl-CoA hydratase
BRM77_RS09780	COG2205	protein histidine kinase activity
BRM77_RS09780	COG0784	Response regulator, receiver
BRM77_RS09780	COG2198	Histidine kinase
BRM77_RS09855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRM77_RS09865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM77_RS09870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRM77_RS09880	COG0505	Belongs to the CarA family
BRM77_RS09885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRM77_RS09895	COG2258	MOSC domain
BRM77_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRM77_RS09950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRM77_RS09970	COG0477	Major facilitator Superfamily
BRM77_RS09980	COG1070	Carbohydrate kinase
BRM77_RS09990	COG1501	Belongs to the glycosyl hydrolase 31 family
BRM77_RS10005	COG0800	Aldolase
BRM77_RS10010	COG4948	Mandelate Racemase Muconate Lactonizing
BRM77_RS10020	COG3734	2-keto-3-deoxy-galactonokinase
BRM77_RS10025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRM77_RS10035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM77_RS10050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRM77_RS10055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRM77_RS10065	COG0351	phosphomethylpyrimidine kinase
BRM77_RS10095	COG0583	DNA-binding transcription factor activity
BRM77_RS10100	COG1741	Belongs to the pirin family
BRM77_RS10120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRM77_RS10125	COG0305	Participates in initiation and elongation during chromosome replication
BRM77_RS10150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRM77_RS10155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRM77_RS10160	COG2137	regulation of response to DNA damage stimulus
BRM77_RS10170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRM77_RS10185	COG1546	Belongs to the CinA family
BRM77_RS10190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRM77_RS10205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRM77_RS10215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRM77_RS10220	COG1534	Rna-binding protein
BRM77_RS10235	COG1238	metal cluster binding
BRM77_RS10240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM77_RS10245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRM77_RS10250	COG2840	Smr protein MutS2
BRM77_RS10265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRM77_RS10280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRM77_RS10285	COG0148	phosphopyruvate hydratase activity
BRM77_RS10295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRM77_RS10300	COG0504	CTP synthase activity
BRM77_RS10325	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BRM77_RS10330	COG0306	phosphate transporter
BRM77_RS10345	COG1253	flavin adenine dinucleotide binding
BRM77_RS10360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRM77_RS10380	COG0477	Major facilitator Superfamily
BRM77_RS10390	COG1132	(ABC) transporter
BRM77_RS10395	COG1136	(ABC) transporter
BRM77_RS10415	COG0438	transferase activity, transferring glycosyl groups
BRM77_RS10425	COG2264	protein methyltransferase activity
BRM77_RS10455	COG2244	polysaccharide biosynthetic process
BRM77_RS10505	COG1595	DNA-templated transcription, initiation
BRM77_RS10520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM77_RS10540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM77_RS10580	COG0140	phosphoribosyl-ATP diphosphatase activity
BRM77_RS10580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRM77_RS10590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRM77_RS10600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BRM77_RS10600	COG0131	Imidazoleglycerol-phosphate dehydratase
BRM77_RS10615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRM77_RS10635	COG0124	histidyl-tRNA synthetase
BRM77_RS10650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRM77_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
BRM77_RS10710	COG0697	spore germination
BRM77_RS10720	COG1794	racemase activity, acting on amino acids and derivatives
BRM77_RS10745	COG0671	phosphoesterase, PA-phosphatase related
BRM77_RS10760	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRM77_RS10775	COG2183	response to ionizing radiation
BRM77_RS10785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM77_RS10785	COG0723	plastoquinol--plastocyanin reductase activity
BRM77_RS10800	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRM77_RS10810	COG1183	phosphatidylcholine synthase activity
BRM77_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS10835	COG3039	Transposase
BRM77_RS10875	COG0668	transmembrane transport
BRM77_RS10895	COG1914	H( )-stimulated, divalent metal cation uptake system
BRM77_RS10920	COG0583	DNA-binding transcription factor activity
BRM77_RS10950	COG0583	DNA-binding transcription factor activity
BRM77_RS10955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM77_RS10960	COG3002	Belongs to the UPF0753 family
BRM77_RS10975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRM77_RS10995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRM77_RS11005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRM77_RS11010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRM77_RS11020	COG0776	regulation of translation
BRM77_RS11025	COG0539	negative regulation of cytoplasmic translation
BRM77_RS11030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRM77_RS11045	COG2957	Belongs to the agmatine deiminase family
BRM77_RS11055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM77_RS11080	COG0395	ABC-type sugar transport system, permease component
BRM77_RS11085	COG1175	transmembrane transport
BRM77_RS11115	COG2350	Protein conserved in bacteria
BRM77_RS11120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRM77_RS11125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRM77_RS11130	COG1187	pseudouridine synthase activity
BRM77_RS11155	COG0436	Aminotransferase
BRM77_RS11220	COG0277	FAD linked oxidase domain protein
BRM77_RS11225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRM77_RS11235	COG0531	amino acid
BRM77_RS11240	COG0531	amino acid
BRM77_RS11250	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BRM77_RS11285	COG2201	protein-glutamate methylesterase activity
BRM77_RS11350	COG0583	DNA-binding transcription factor activity
BRM77_RS11360	COG3039	Transposase
BRM77_RS11410	COG3039	Transposase
BRM77_RS11415	COG3039	Transposase
BRM77_RS11430	COG1278	Cold shock
BRM77_RS11440	COG3328	transposase activity
BRM77_RS11465	COG3039	Transposase
BRM77_RS11480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM77_RS11500	COG0557	exoribonuclease II activity
BRM77_RS11530	COG1960	acyl-CoA dehydrogenase activity
BRM77_RS11535	COG2226	methyltransferase
BRM77_RS11540	COG0646	methionine synthase
BRM77_RS11540	COG1410	methionine synthase
BRM77_RS11545	COG0646	methionine synthase
BRM77_RS11545	COG1410	methionine synthase
BRM77_RS11555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM77_RS11565	COG1609	Transcriptional regulator
BRM77_RS11580	COG2900	Belongs to the SlyX family
BRM77_RS11595	COG0386	Belongs to the glutathione peroxidase family
BRM77_RS11605	COG1725	Transcriptional regulator
BRM77_RS11610	COG1131	(ABC) transporter
BRM77_RS11690	COG2850	peptidyl-arginine hydroxylation
BRM77_RS11725	COG1132	(ABC) transporter
BRM77_RS11740	COG0583	DNA-binding transcription factor activity
BRM77_RS11760	COG1605	Chorismate mutase
BRM77_RS11760	COG0287	Prephenate dehydrogenase
BRM77_RS11765	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRM77_RS11775	COG0484	heat shock protein binding
BRM77_RS11780	COG0443	Heat shock 70 kDa protein
BRM77_RS11785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRM77_RS11795	COG0497	DNA recombination
BRM77_RS11805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM77_RS11815	COG2914	Belongs to the UPF0125 (RnfH) family
BRM77_RS11840	COG1960	acyl-CoA dehydrogenase activity
BRM77_RS11850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRM77_RS11895	COG2814	Major facilitator Superfamily
BRM77_RS11900	COG1566	PFAM secretion protein HlyD family protein
BRM77_RS11940	COG4774	siderophore transport
BRM77_RS11955	COG0367	asparagine synthase
BRM77_RS11970	COG1393	Belongs to the ArsC family
BRM77_RS12030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRM77_RS12045	COG0233	cytoplasmic translational termination
BRM77_RS12055	COG0575	Belongs to the CDS family
BRM77_RS12065	COG0750	zinc metalloprotease
BRM77_RS12085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM77_RS12090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM77_RS12110	COG0825	malonyl-CoA metabolic process
BRM77_RS12120	COG4771	TonB-dependent receptor
BRM77_RS12125	COG1131	(ABC) transporter
BRM77_RS12145	COG1981	membrane
BRM77_RS12190	COG2895	sulfate adenylyltransferase (ATP) activity
BRM77_RS12190	COG0529	Catalyzes the synthesis of activated sulfate
BRM77_RS12225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM77_RS12240	COG2040	homocysteine
BRM77_RS12245	COG0833	amino acid
BRM77_RS12265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM77_RS12265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM77_RS12275	COG2878	Part of a membrane complex involved in electron transport
BRM77_RS12295	COG1595	DNA-templated transcription, initiation
BRM77_RS12320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM77_RS12335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM77_RS12340	COG0251	oxidation-reduction process
BRM77_RS12350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRM77_RS12350	COG0392	lysyltransferase activity
BRM77_RS12405	COG2814	Major facilitator Superfamily
BRM77_RS12410	COG1902	pentaerythritol trinitrate reductase activity
BRM77_RS12425	COG2824	Alkylphosphonate utilization operon protein PhnA
BRM77_RS12440	COG1047	Peptidyl-prolyl cis-trans
BRM77_RS12485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRM77_RS12500	COG1451	nucleotide metabolic process
BRM77_RS12525	COG0183	Belongs to the thiolase family
BRM77_RS12555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRM77_RS12555	COG1793	dna ligase
BRM77_RS12565	COG1793	dna ligase
BRM77_RS12570	COG1201	RNA secondary structure unwinding
BRM77_RS12590	COG1278	Cold shock
BRM77_RS12595	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRM77_RS12600	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BRM77_RS12610	COG3046	protein related to deoxyribodipyrimidine photolyase
BRM77_RS12615	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRM77_RS12620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRM77_RS12635	COG2954	triphosphatase activity
BRM77_RS12650	COG1381	Involved in DNA repair and RecF pathway recombination
BRM77_RS12680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM77_RS12695	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM77_RS12695	COG1024	Enoyl-CoA hydratase
BRM77_RS12715	COG1024	Enoyl-CoA hydratase
BRM77_RS12720	COG1960	acyl-CoA dehydrogenase activity
BRM77_RS12790	COG2353	YceI-like domain
BRM77_RS12800	COG2353	YceI-like domain
BRM77_RS12815	COG1760	l-serine dehydratase
BRM77_RS12825	COG0626	cystathionine gamma-synthase activity
BRM77_RS12830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM77_RS12835	COG0739	heme binding
BRM77_RS12845	COG1272	protein, Hemolysin III
BRM77_RS12865	COG0463	Glycosyl transferase, family 2
BRM77_RS12875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRM77_RS12885	COG4771	TonB-dependent receptor
BRM77_RS12890	COG1309	transcriptional regulator
BRM77_RS12900	COG1960	acyl-CoA dehydrogenase activity
BRM77_RS12935	COG0509	glycine decarboxylation via glycine cleavage system
BRM77_RS12950	COG0330	HflC and HflK could
BRM77_RS12965	COG3956	TIGRFAM MazG family protein
BRM77_RS12975	COG0494	nUDIX hydrolase
BRM77_RS12985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRM77_RS12990	COG0837	glucose binding
BRM77_RS13005	COG1388	LysM domain
BRM77_RS13005	COG3858	chitin binding
BRM77_RS13025	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM77_RS13055	COG3039	Transposase
BRM77_RS13105	COG3537	Alpha-1,2-mannosidase
BRM77_RS13165	COG3142	Participates in the control of copper homeostasis
BRM77_RS13170	COG1446	asparaginase
BRM77_RS13215	COG0643	Histidine kinase
BRM77_RS13215	COG2198	Histidine kinase
BRM77_RS13215	COG0784	Response regulator, receiver
BRM77_RS13220	COG0840	transmembrane signaling receptor activity
BRM77_RS13225	COG0835	chemotaxis
BRM77_RS13240	COG0189	ligase activity
BRM77_RS13250	COG1397	ADP-ribosylglycohydrolase
BRM77_RS13260	COG1199	ATP-dependent helicase activity
BRM77_RS13270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRM77_RS13275	COG1215	transferase activity, transferring glycosyl groups
BRM77_RS13285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM77_RS13340	COG1643	Atp-dependent helicase
BRM77_RS13345	COG0783	Belongs to the Dps family
BRM77_RS13355	COG0514	ATP-dependent DNA helicase (RecQ)
BRM77_RS13380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRM77_RS13440	COG1187	pseudouridine synthase activity
BRM77_RS13450	COG0602	queuosine metabolic process
BRM77_RS13460	COG2885	chlorophyll binding
BRM77_RS13475	COG0848	biopolymer transport protein
BRM77_RS13485	COG0824	Thioesterase
BRM77_RS13490	COG2255	four-way junction helicase activity
BRM77_RS13500	COG0632	four-way junction helicase activity
BRM77_RS13620	COG3209	COG3209 Rhs family protein
BRM77_RS13620	COG3209	COG3209 Rhs family protein
BRM77_RS13640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRM77_RS13645	COG1845	cytochrome c oxidase, subunit III
BRM77_RS13650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRM77_RS13665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRM77_RS13670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRM77_RS13680	COG0196	riboflavin kinase activity
BRM77_RS13685	COG0728	peptidoglycan biosynthetic process
BRM77_RS13690	COG0268	Binds directly to 16S ribosomal RNA
BRM77_RS13695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRM77_RS13700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRM77_RS13710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRM77_RS13715	COG0824	Thioesterase
BRM77_RS13730	COG1946	Acyl-CoA thioesterase
BRM77_RS13740	COG1595	DNA-templated transcription, initiation
BRM77_RS13760	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BRM77_RS13800	COG1877	trehalose-phosphatase activity
BRM77_RS13805	COG3387	PFAM Glycoside hydrolase 15-related
BRM77_RS13830	COG0564	pseudouridine synthase activity
BRM77_RS13835	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM77_RS13840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM77_RS13840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRM77_RS13855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRM77_RS13860	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM77_RS13900	COG2194	sulfuric ester hydrolase activity
BRM77_RS13905	COG4969	Belongs to the N-Me-Phe pilin family
BRM77_RS13915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRM77_RS13960	COG3039	Transposase
BRM77_RS13975	COG3039	Transposase
BRM77_RS14000	COG1132	(ABC) transporter
BRM77_RS14030	COG0745	RESPONSE REGULATOR receiver
BRM77_RS14035	COG5002	protein histidine kinase activity
BRM77_RS14035	COG5000	phosphorelay sensor kinase activity
BRM77_RS14040	COG0475	glutathione-regulated potassium exporter activity
BRM77_RS14050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM77_RS14075	COG1187	pseudouridine synthase activity
BRM77_RS14080	COG5001	Diguanylate cyclase
BRM77_RS14080	COG5002	protein histidine kinase activity
BRM77_RS14140	COG3039	Transposase
BRM77_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS14205	COG0415	Belongs to the DNA photolyase family
BRM77_RS14210	COG0305	Participates in initiation and elongation during chromosome replication
BRM77_RS14220	COG0367	asparagine synthase
BRM77_RS14235	COG1960	acyl-CoA dehydrogenase activity
BRM77_RS14250	COG0084	hydrolase, TatD family'
BRM77_RS14255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRM77_RS14320	COG0735	belongs to the Fur family
BRM77_RS14325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRM77_RS14360	COG3039	Transposase
BRM77_RS14385	COG3039	Transposase
BRM77_RS14410	COG2205	protein histidine kinase activity
BRM77_RS14430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRM77_RS14440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRM77_RS14450	COG2198	Histidine kinase
BRM77_RS14450	COG0643	Histidine kinase
BRM77_RS14455	COG0840	transmembrane signaling receptor activity
BRM77_RS14460	COG0835	chemotaxis
BRM77_RS14465	COG2202	Pas domain
BRM77_RS14465	COG2200	EAL domain
BRM77_RS14465	COG2199	diguanylate cyclase activity
BRM77_RS14470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRM77_RS14485	COG3590	peptidase
BRM77_RS14505	COG1515	deoxyribonuclease V activity
BRM77_RS14515	COG1741	Belongs to the pirin family
BRM77_RS14630	COG1741	Belongs to the pirin family
BRM77_RS14635	COG1966	Carbon starvation protein
BRM77_RS14640	COG2879	small protein
BRM77_RS14680	COG4251	negative regulation of phosphorylation
BRM77_RS14680	COG3706	GGDEF domain
BRM77_RS14680	COG2203	Gaf domain
BRM77_RS14680	COG5001	Diguanylate cyclase
BRM77_RS14690	COG0629	single-stranded DNA binding
BRM77_RS14695	COG0142	geranyltranstransferase activity
BRM77_RS14725	COG0527	aspartate kinase activity
BRM77_RS14735	COG0384	phenazine biosynthesis protein PhzF
BRM77_RS14745	COG1764	response to oxidative stress
BRM77_RS14760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRM77_RS14765	COG1678	Uncharacterized ACR, COG1678
BRM77_RS14775	COG0519	Catalyzes the synthesis of GMP from XMP
BRM77_RS14810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRM77_RS14855	COG0693	protein deglycase activity
BRM77_RS14875	COG1959	2 iron, 2 sulfur cluster binding
BRM77_RS14880	COG0719	Fe-S assembly protein
BRM77_RS14885	COG0396	ATPase activity
BRM77_RS14890	COG0719	Fe-S assembly protein
BRM77_RS14895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRM77_RS14905	COG2146	nitrite reductase [NAD(P)H] activity
BRM77_RS14935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM77_RS14950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRM77_RS14960	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRM77_RS14965	COG0174	glutamine synthetase
BRM77_RS14970	COG3328	transposase activity
BRM77_RS15005	COG2207	Transcriptional regulator
BRM77_RS15025	COG2755	lipolytic protein G-D-S-L family
BRM77_RS15025	COG0657	acetylesterase activity
BRM77_RS15050	COG0488	(ABC) transporter
BRM77_RS15085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRM77_RS15085	COG4651	solute:proton antiporter activity
BRM77_RS15100	COG4772	TonB-dependent receptor
BRM77_RS15110	COG4264	IucA IucC family
BRM77_RS15115	COG2814	Major facilitator Superfamily
BRM77_RS15125	COG0019	diaminopimelate decarboxylase activity
BRM77_RS15185	COG4206	TonB-dependent receptor
BRM77_RS15225	COG0542	response to heat
BRM77_RS15265	COG0534	Mate efflux family protein
BRM77_RS15280	COG0336	Belongs to the RNA methyltransferase TrmD family
BRM77_RS15285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRM77_RS15290	COG0228	four-way junction DNA binding
BRM77_RS15315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRM77_RS15325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM77_RS15375	COG1555	photosystem II stabilization
BRM77_RS15380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM77_RS15395	COG3178	'Phosphotransferase
BRM77_RS15400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRM77_RS15410	COG0628	permease
BRM77_RS15420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRM77_RS15435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRM77_RS15455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRM77_RS15465	COG0271	Belongs to the BolA IbaG family
BRM77_RS15475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRM77_RS15485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRM77_RS15490	COG1137	ATPase activity
BRM77_RS15505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM77_RS15510	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRM77_RS15515	COG1660	Displays ATPase and GTPase activities
BRM77_RS15525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM77_RS15530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM77_RS15540	COG2239	Acts as a magnesium transporter
BRM77_RS15550	COG1294	oxidase, subunit
BRM77_RS15555	COG1271	oxidase subunit
BRM77_RS15575	COG1113	amino acid transport
BRM77_RS15590	COG2197	response regulator
BRM77_RS15595	COG0531	amino acid
BRM77_RS15665	COG0754	glutathionylspermidine amidase activity
BRM77_RS15690	COG1842	Phage shock protein A
BRM77_RS15705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRM77_RS15760	COG2201	protein-glutamate methylesterase activity
BRM77_RS15780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM77_RS15785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM77_RS15840	COG1858	cytochrome C peroxidase
BRM77_RS15870	COG0515	serine threonine protein kinase
BRM77_RS15875	COG0631	protein serine/threonine phosphatase activity
BRM77_RS15985	COG3039	Transposase
BRM77_RS16005	COG3039	Transposase
BRM77_RS16050	COG0316	Belongs to the HesB IscA family
BRM77_RS16050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRM77_RS16055	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRM77_RS16065	COG0428	transporter
BRM77_RS16070	COG0428	transporter
BRM77_RS16075	COG3064	Membrane
BRM77_RS16085	COG1530	ribonuclease E activity
BRM77_RS16105	COG1054	Belongs to the UPF0176 family
BRM77_RS16110	COG3039	Transposase
BRM77_RS16130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRM77_RS16170	COG3039	Transposase
BRM77_RS16175	COG3039	Transposase
BRM77_RS16205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRM77_RS16205	COG1648	precorrin-2 dehydrogenase activity
BRM77_RS16230	COG0746	molybdenum cofactor guanylyltransferase activity
BRM77_RS16335	COG4206	TonB-dependent receptor
BRM77_RS16385	COG0531	amino acid
BRM77_RS16400	COG0006	proline dipeptidase activity
BRM77_RS16410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM77_RS16425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM77_RS16430	COG3938	Belongs to the proline racemase family
BRM77_RS16440	COG0552	protein localization to endoplasmic reticulum
BRM77_RS16465	COG0784	Response regulator, receiver
BRM77_RS16465	COG4191	Histidine kinase
BRM77_RS16555	COG3040	lipid binding
BRM77_RS16595	COG0438	transferase activity, transferring glycosyl groups
BRM77_RS16605	COG0438	transferase activity, transferring glycosyl groups
BRM77_RS16610	COG0438	transferase activity, transferring glycosyl groups
BRM77_RS16680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRM77_RS16720	COG4969	Belongs to the N-Me-Phe pilin family
BRM77_RS16760	COG1611	Belongs to the LOG family
BRM77_RS16775	COG2095	MarC family integral membrane protein
BRM77_RS16785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM77_RS16820	COG1185	polyribonucleotide nucleotidyltransferase activity
BRM77_RS16825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRM77_RS16845	COG0195	Participates in both transcription termination and antitermination
BRM77_RS16850	COG0779	Required for maturation of 30S ribosomal subunits
BRM77_RS16860	COG1007	ATP synthesis coupled electron transport
BRM77_RS16895	COG1034	ATP synthesis coupled electron transport
BRM77_RS16900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRM77_RS16905	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRM77_RS16910	COG0649	NAD binding
BRM77_RS16915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM77_RS16925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM77_RS16940	COG0149	triose-phosphate isomerase activity
BRM77_RS16990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM77_RS16995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRM77_RS17020	COG0135	phosphoribosylanthranilate isomerase activity
BRM77_RS17025	COG0101	tRNA pseudouridine synthase activity
BRM77_RS17045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRM77_RS17050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRM77_RS17055	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRM77_RS17060	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM77_RS17115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM77_RS17125	COG0412	Dienelactone hydrolase
BRM77_RS17145	COG0717	Belongs to the dCTP deaminase family
BRM77_RS17150	COG0489	protein tyrosine kinase activity
BRM77_RS17195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM77_RS17200	COG2311	Membrane
BRM77_RS17205	COG1047	Peptidyl-prolyl cis-trans
BRM77_RS17210	COG0791	NLP P60 protein
BRM77_RS17215	COG0791	NLP P60 protein
BRM77_RS17230	COG1301	dicarboxylic acid transport
BRM77_RS17235	COG1785	Belongs to the alkaline phosphatase family
BRM77_RS17240	COG0037	tRNA processing
BRM77_RS17245	COG1722	exodeoxyribonuclease VII activity
BRM77_RS17250	COG0142	geranyltranstransferase activity
BRM77_RS17275	COG0312	modulator of DNA gyrase
BRM77_RS17280	COG3028	Belongs to the UPF0307 family
BRM77_RS17285	COG0312	modulator of DNA gyrase
BRM77_RS17295	COG3164	Protein of unknown function
BRM77_RS17310	COG2968	Membrane
BRM77_RS17335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRM77_RS17360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRM77_RS17390	COG3118	belongs to the thioredoxin family
BRM77_RS17470	COG3039	Transposase
BRM77_RS17475	COG3039	Transposase
BRM77_RS17570	COG2022	thiamine diphosphate biosynthetic process
BRM77_RS17585	COG0471	metal ion transport
BRM77_RS17585	COG3273	potassium ion transport
BRM77_RS17615	COG1970	mechanosensitive ion channel activity
BRM77_RS17640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM77_RS17670	COG0308	aminopeptidase N
BRM77_RS17675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM77_RS17690	COG2895	sulfate adenylyltransferase (ATP) activity
BRM77_RS17690	COG0529	Catalyzes the synthesis of activated sulfate
BRM77_RS17695	COG0175	sulfate reduction
BRM77_RS17700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM77_RS17705	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRM77_RS17710	COG0175	sulfate reduction
BRM77_RS17730	COG2198	Histidine kinase
BRM77_RS17730	COG0784	Response regulator, receiver
BRM77_RS17730	COG2205	protein histidine kinase activity
BRM77_RS17775	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRM77_RS17780	COG3588	fructose-bisphosphate aldolase
BRM77_RS17785	COG0469	pyruvate kinase activity
BRM77_RS17830	COG0753	catalase activity
BRM77_RS17855	COG3039	Transposase
BRM77_RS17875	COG1917	Cupin 2, conserved barrel domain protein
BRM77_RS17875	COG2207	Transcriptional regulator
BRM77_RS17905	COG0823	Involved in the tonB-independent uptake of proteins
BRM77_RS17905	COG1506	peptidase
BRM77_RS17930	COG3039	Transposase
BRM77_RS17935	COG1297	OPT oligopeptide transporter protein
BRM77_RS18040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRM77_RS18045	COG3039	Transposase
BRM77_RS18065	COG3039	Transposase
BRM77_RS18070	COG0732	type I restriction modification DNA specificity domain
BRM77_RS18075	COG3039	Transposase
BRM77_RS18085	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRM77_RS18090	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRM77_RS18110	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRM77_RS18310	COG3179	chitinase
BRM77_RS18365	COG3039	Transposase
BRM77_RS18500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRM77_RS18515	COG2197	response regulator
BRM77_RS18520	COG4585	Histidine kinase
BRM77_RS18540	COG2894	cell division
BRM77_RS18545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRM77_RS18555	COG0642	Histidine kinase
BRM77_RS18560	COG0745	RESPONSE REGULATOR receiver
BRM77_RS18565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRM77_RS18575	COG2194	sulfuric ester hydrolase activity
BRM77_RS18605	COG3551	Protein conserved in bacteria
BRM77_RS18670	COG0203	ribosomal protein L17
BRM77_RS18680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRM77_RS18685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRM77_RS18695	COG0201	protein transport
BRM77_RS18705	COG1841	ribosomal large subunit assembly
BRM77_RS18735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRM77_RS18745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRM77_RS18750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRM77_RS18755	COG0255	Belongs to the universal ribosomal protein uL29 family
BRM77_RS18760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRM77_RS18770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRM77_RS18785	COG0089	rRNA binding
BRM77_RS18790	COG0088	Forms part of the polypeptide exit tunnel
BRM77_RS18795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRM77_RS18800	COG0051	transcription antitermination factor activity, RNA binding
BRM77_RS18820	COG0049	tRNA binding
BRM77_RS18825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRM77_RS18830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRM77_RS18835	COG0085	RNA polymerase activity
BRM77_RS18840	COG0222	ribosome binding
BRM77_RS18845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRM77_RS18855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRM77_RS18865	COG0250	Participates in transcription elongation, termination and antitermination
BRM77_RS18870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRM77_RS18900	COG0012	GTP binding
BRM77_RS18905	COG0193	aminoacyl-tRNA hydrolase activity
BRM77_RS18915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRM77_RS18930	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BRM77_RS18945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRM77_RS18955	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRM77_RS18975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM77_RS18980	COG1295	ribonuclease BN
BRM77_RS19010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRM77_RS19020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRM77_RS19050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRM77_RS19075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRM77_RS19090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM77_RS19090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM77_RS19140	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM77_RS19150	COG3634	alkyl hydroperoxide reductase activity
BRM77_RS19155	COG0583	DNA-binding transcription factor activity
BRM77_RS19165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM77_RS19245	COG4783	chaperone-mediated protein folding
BRM77_RS19260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRM77_RS19270	COG0438	transferase activity, transferring glycosyl groups
BRM77_RS19275	COG0671	phosphoesterase, PA-phosphatase related
BRM77_RS19280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM77_RS19300	COG2833	Protein of unknown function (DUF455)
BRM77_RS19320	COG0285	dihydrofolate synthase activity
BRM77_RS19330	COG0406	alpha-ribazole phosphatase activity
BRM77_RS19365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRM77_RS19370	COG4208	sulfate ABC transporter
BRM77_RS19375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRM77_RS19380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRM77_RS19385	COG0156	8-amino-7-oxononanoate synthase activity
BRM77_RS19415	COG0604	alcohol dehydrogenase
BRM77_RS19420	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRM77_RS19420	COG1902	pentaerythritol trinitrate reductase activity
BRM77_RS19560	COG3386	PFAM SMP-30 Gluconolaconase
BRM77_RS19580	COG1024	Enoyl-CoA hydratase
BRM77_RS19590	COG0318	PFAM AMP-dependent synthetase and ligase
BRM77_RS19595	COG0583	DNA-binding transcription factor activity
BRM77_RS19635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM77_RS19640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM77_RS19650	COG2096	Adenosyltransferase
BRM77_RS19655	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRM77_RS19670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRM77_RS19680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRM77_RS19685	COG2967	ApaG domain
BRM77_RS19710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRM77_RS19730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRM77_RS19755	COG0642	Histidine kinase
BRM77_RS19770	COG4181	ATPase activity
BRM77_RS19780	COG2175	clavaminate synthase activity
BRM77_RS19830	COG0667	Aldo Keto reductase
BRM77_RS19840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRM77_RS19845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM77_RS19865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM77_RS19880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRM77_RS19935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRM77_RS19940	COG2226	methyltransferase
BRM77_RS19995	COG0604	alcohol dehydrogenase
BRM77_RS19995	COG3321	synthase
BRM77_RS19995	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS20010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRM77_RS20025	COG0494	nUDIX hydrolase
BRM77_RS20040	COG1388	LysM domain
BRM77_RS20040	COG4942	peptidase
BRM77_RS20050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRM77_RS20065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRM77_RS20070	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRM77_RS20075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM77_RS20090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRM77_RS20095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRM77_RS20110	COG3116	cell division
BRM77_RS20115	COG0275	rRNA processing
BRM77_RS20150	COG0792	nuclease activity
BRM77_RS20155	COG1988	membrane-bound metal-dependent
BRM77_RS20160	COG0277	FAD linked oxidase domain protein
BRM77_RS20165	COG0745	RESPONSE REGULATOR receiver
BRM77_RS20170	COG2205	protein histidine kinase activity
BRM77_RS20180	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRM77_RS20185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRM77_RS20210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRM77_RS20215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM77_RS20220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRM77_RS20240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM77_RS20240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM77_RS20260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRM77_RS20280	COG0488	(ABC) transporter
BRM77_RS20330	COG2205	protein histidine kinase activity
BRM77_RS20370	COG2205	protein histidine kinase activity
BRM77_RS20390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRM77_RS20425	COG3039	Transposase
BRM77_RS20430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM77_RS20445	COG3039	Transposase
BRM77_RS20500	COG3039	Transposase
BRM77_RS20550	COG1649	PFAM Uncharacterised BCR, COG1649
BRM77_RS20550	COG0726	polysaccharide deacetylase
BRM77_RS20555	COG1215	transferase activity, transferring glycosyl groups
BRM77_RS20565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRM77_RS20570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM77_RS20575	COG1609	Transcriptional regulator
BRM77_RS20585	COG2188	Transcriptional regulator
BRM77_RS20600	COG3250	beta-galactosidase activity
BRM77_RS20655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRM77_RS20660	COG4191	Histidine kinase
BRM77_RS20665	COG0784	Response regulator, receiver
BRM77_RS20670	COG4251	negative regulation of phosphorylation
BRM77_RS20675	COG2823	Periplasmic or secreted lipoprotein
BRM77_RS20680	COG0673	inositol 2-dehydrogenase activity
BRM77_RS20685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRM77_RS20720	COG1051	belongs to the nudix hydrolase family
BRM77_RS20720	COG1056	cytidyltransferase-related domain
BRM77_RS20755	COG2921	Belongs to the UPF0250 family
BRM77_RS20770	COG1686	Belongs to the peptidase S11 family
BRM77_RS20780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRM77_RS20785	COG2951	lytic endotransglycosylase activity
BRM77_RS20800	COG1388	LysM domain
BRM77_RS20800	COG3409	Peptidoglycan-binding domain 1 protein
BRM77_RS20800	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRM77_RS20840	COG0772	Belongs to the SEDS family
BRM77_RS20855	COG1792	Involved in formation and maintenance of cell shape
BRM77_RS20860	COG1077	Cell shape determining protein MreB Mrl
BRM77_RS20865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM77_RS20910	COG2199	diguanylate cyclase activity
BRM77_RS20915	COG0308	aminopeptidase N
BRM77_RS20945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRM77_RS20975	COG0436	Aminotransferase
BRM77_RS20990	COG1505	serine-type exopeptidase activity
BRM77_RS21015	COG0181	hydroxymethylbilane synthase activity
BRM77_RS21025	COG3275	phosphorelay sensor kinase activity
BRM77_RS21070	COG0659	secondary active sulfate transmembrane transporter activity
BRM77_RS21075	COG5297	Belongs to the glycosyl hydrolase family 6
BRM77_RS21075	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM77_RS21150	COG0598	Magnesium transport protein CorA
BRM77_RS21160	COG1113	amino acid transport
BRM77_RS21170	COG5297	Belongs to the glycosyl hydrolase family 6
BRM77_RS21175	COG4305	rare lipoprotein A
BRM77_RS21180	COG0697	spore germination
BRM77_RS21240	COG4221	oxidoreductase activity
BRM77_RS21270	COG0456	acetyltransferase
BRM77_RS21280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRM77_RS21335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM77_RS21335	COG2111	Na H antiporter
BRM77_RS21340	COG1006	Multisubunit Na H antiporter MnhC subunit
BRM77_RS21345	COG0651	ATP synthesis coupled electron transport
BRM77_RS21355	COG2212	antiporter activity
BRM77_RS21360	COG1320	monovalent cation:proton antiporter activity
BRM77_RS21370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BRM77_RS21390	COG3104	oligopeptide transport
BRM77_RS21395	COG3483	tryptophan 2,3-dioxygenase activity
BRM77_RS21405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRM77_RS21440	COG0183	Belongs to the thiolase family
BRM77_RS21495	COG3039	Transposase
BRM77_RS21525	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRM77_RS21530	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRM77_RS21540	COG4948	Mandelate Racemase Muconate Lactonizing
BRM77_RS21580	COG0531	amino acid
BRM77_RS21615	COG4682	membrane
BRM77_RS21620	COG2133	pyrroloquinoline quinone binding
BRM77_RS21660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRM77_RS21665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRM77_RS21675	COG1610	YqeY-like protein
BRM77_RS21690	COG1295	ribonuclease BN
BRM77_RS21695	COG0358	DNA primase activity
BRM77_RS21760	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRM77_RS21775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRM77_RS21825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRM77_RS21830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRM77_RS21835	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BRM77_RS21845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BRM77_RS21850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM77_RS21865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRM77_RS21945	COG3039	Transposase
BRM77_RS21960	COG3328	transposase activity
BRM77_RS21975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM77_RS21975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM77_RS21985	COG1473	amidohydrolase
BRM77_RS21990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM77_RS21995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM77_RS22010	COG5383	Protein conserved in bacteria
BRM77_RS22050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRM77_RS22055	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRM77_RS22070	COG0028	Belongs to the TPP enzyme family
BRM77_RS22075	COG4191	Histidine kinase
BRM77_RS22100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRM77_RS22115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM77_RS22120	COG3177	Filamentation induced by cAMP protein fic
BRM77_RS22135	COG0596	Alpha beta hydrolase
BRM77_RS22140	COG0727	PFAM Uncharacterised protein family (UPF0153)
BRM77_RS22145	COG0318	PFAM AMP-dependent synthetase and ligase
BRM77_RS22150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRM77_RS22205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRM77_RS22215	COG0129	dihydroxy-acid dehydratase activity
BRM77_RS22240	COG3039	Transposase
BRM77_RS22250	COG0408	coproporphyrinogen oxidase activity
BRM77_RS22350	COG2353	YceI-like domain
BRM77_RS22380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM77_RS22395	COG3386	PFAM SMP-30 Gluconolaconase
BRM77_RS22435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRM77_RS22450	COG4771	TonB-dependent receptor
BRM77_RS22460	COG0459	protein refolding
BRM77_RS22485	COG1252	NADH dehydrogenase
BRM77_RS22495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM77_RS22500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRM77_RS22505	COG3437	response regulator, receiver
BRM77_RS22510	COG2177	Part of the ABC transporter FtsEX involved in
BRM77_RS22515	COG2884	Cell division ATP-binding protein ftsE
BRM77_RS22525	COG3118	belongs to the thioredoxin family
BRM77_RS22530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRM77_RS22545	COG0729	surface antigen
BRM77_RS22550	COG2911	Protein conserved in bacteria
BRM77_RS22585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM77_RS22600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM77_RS22660	COG1733	regulation of RNA biosynthetic process
BRM77_RS22665	COG0702	epimerase
BRM77_RS22700	COG0583	DNA-binding transcription factor activity
BRM77_RS22705	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM77_RS22725	COG0745	RESPONSE REGULATOR receiver
BRM77_RS22755	COG1902	pentaerythritol trinitrate reductase activity
BRM77_RS22760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRM77_RS22770	COG2814	Major facilitator Superfamily
BRM77_RS22775	COG0583	DNA-binding transcription factor activity
BRM77_RS22795	COG0084	hydrolase, TatD family'
BRM77_RS22845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM77_RS22865	COG2072	flavoprotein involved in K transport
BRM77_RS22915	COG4770	biotin carboxylase activity
BRM77_RS22920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRM77_RS22925	COG1960	acyl-CoA dehydrogenase activity
BRM77_RS22980	COG0523	cobalamin synthesis protein
BRM77_RS22990	COG0697	spore germination
BRM77_RS23000	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRM77_RS23015	COG4771	TonB-dependent receptor
BRM77_RS23020	COG0457	Tetratricopeptide repeat
BRM77_RS23035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM77_RS23060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRM77_RS23060	COG0519	Catalyzes the synthesis of GMP from XMP
BRM77_RS23070	COG0805	protein transport
BRM77_RS23080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRM77_RS23090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRM77_RS23145	COG3661	Belongs to the glycosyl hydrolase 67 family
BRM77_RS23155	COG4948	Mandelate Racemase Muconate Lactonizing
BRM77_RS23165	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM77_RS23170	COG0246	Mannitol dehydrogenase
BRM77_RS23195	COG3693	PFAM glycoside hydrolase, family 10
BRM77_RS23220	COG2211	Major facilitator Superfamily
BRM77_RS23265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRM77_RS23315	COG1846	Transcriptional regulator
BRM77_RS23320	COG1764	response to oxidative stress
BRM77_RS23420	COG3549	Plasmid maintenance system killer
BRM77_RS23430	COG1074	ATP-dependent DNA helicase activity
BRM77_RS23435	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRM77_RS23475	COG2032	superoxide dismutase activity
BRM77_RS23480	COG2032	superoxide dismutase activity
BRM77_RS23485	COG2204	response regulator
BRM77_RS23490	COG3852	Histidine kinase
BRM77_RS23495	COG0004	ammonium transporteR
BRM77_RS23500	COG0347	Belongs to the P(II) protein family
BRM77_RS23505	COG0174	glutamine synthetase
BRM77_RS23510	COG1968	undecaprenyl-diphosphatase activity
BRM77_RS23555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM77_RS23565	COG2062	phosphohistidine phosphatase, SixA
BRM77_RS23570	COG0489	protein tyrosine kinase activity
BRM77_RS23590	COG1396	sequence-specific DNA binding
BRM77_RS23595	COG3550	peptidyl-serine autophosphorylation
BRM77_RS23600	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRM77_RS23605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM77_RS23620	COG0517	IMP dehydrogenase activity
BRM77_RS23620	COG1125	glycine betaine transport
BRM77_RS23635	COG1119	ATPase activity
BRM77_RS23645	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRM77_RS23660	COG3039	Transposase
BRM77_RS23685	COG0656	L-ascorbic acid biosynthetic process
BRM77_RS23690	COG2130	NADP-dependent
BRM77_RS23695	COG0667	Aldo Keto reductase
BRM77_RS23705	COG1187	pseudouridine synthase activity
BRM77_RS23720	COG1643	Atp-dependent helicase
BRM77_RS23725	COG4807	Protein conserved in bacteria
BRM77_RS23730	COG4948	Mandelate Racemase Muconate Lactonizing
BRM77_RS23740	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRM77_RS23745	COG1028	Short-chain dehydrogenase reductase Sdr
BRM77_RS23765	COG3507	Belongs to the glycosyl hydrolase 43 family
BRM77_RS23810	COG3162	membrane
BRM77_RS23815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRM77_RS23830	COG0708	Exodeoxyribonuclease III
BRM77_RS23845	COG2091	lysine biosynthetic process via aminoadipic acid
BRM77_RS23855	COG3540	Alkaline phosphatase
BRM77_RS23885	COG2159	amidohydrolase
BRM77_RS23910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM77_RS23915	COG0583	DNA-binding transcription factor activity
BRM77_RS23920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM77_RS23940	COG0210	DNA helicase
BRM77_RS23955	COG0531	amino acid
BRM77_RS23965	COG1322	Protein conserved in bacteria
BRM77_RS23975	COG0386	Belongs to the glutathione peroxidase family
BRM77_RS24030	COG0793	Belongs to the peptidase S41A family
BRM77_RS24035	COG4942	peptidase
BRM77_RS24045	COG2234	aminopeptidase activity
BRM77_RS24095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRM77_RS24100	COG0302	gtp cyclohydrolase
BRM77_RS24125	COG0477	Major facilitator Superfamily
BRM77_RS24235	COG1929	Belongs to the glycerate kinase type-1 family
BRM77_RS24240	COG2271	Major facilitator Superfamily
BRM77_RS24255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM77_RS24265	COG0861	Integral membrane protein TerC family
BRM77_RS24275	COG0584	glycerophosphoryl diester phosphodiesterase
BRM77_RS24285	COG0671	phosphoesterase, PA-phosphatase related
BRM77_RS24295	COG0726	polysaccharide deacetylase