locus-tag	class	description
BRM78_RS00025	COG0726	polysaccharide deacetylase
BRM78_RS00035	COG0671	phosphoesterase, PA-phosphatase related
BRM78_RS00045	COG0584	glycerophosphoryl diester phosphodiesterase
BRM78_RS00055	COG0861	Integral membrane protein TerC family
BRM78_RS00065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM78_RS00080	COG2271	Major facilitator Superfamily
BRM78_RS00085	COG1929	Belongs to the glycerate kinase type-1 family
BRM78_RS00190	COG0477	Major facilitator Superfamily
BRM78_RS00215	COG0302	gtp cyclohydrolase
BRM78_RS00220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRM78_RS00270	COG2234	aminopeptidase activity
BRM78_RS00280	COG4942	peptidase
BRM78_RS00285	COG0793	Belongs to the peptidase S41A family
BRM78_RS00340	COG0386	Belongs to the glutathione peroxidase family
BRM78_RS00350	COG1322	Protein conserved in bacteria
BRM78_RS00360	COG0531	amino acid
BRM78_RS00375	COG0210	DNA helicase
BRM78_RS00395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM78_RS00400	COG0583	DNA-binding transcription factor activity
BRM78_RS00405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM78_RS00430	COG2159	amidohydrolase
BRM78_RS00460	COG3540	Alkaline phosphatase
BRM78_RS00470	COG2091	lysine biosynthetic process via aminoadipic acid
BRM78_RS00485	COG0708	Exodeoxyribonuclease III
BRM78_RS00500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRM78_RS00505	COG3162	membrane
BRM78_RS00550	COG3507	Belongs to the glycosyl hydrolase 43 family
BRM78_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS00575	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRM78_RS00585	COG4948	Mandelate Racemase Muconate Lactonizing
BRM78_RS00590	COG4807	Protein conserved in bacteria
BRM78_RS00595	COG1643	Atp-dependent helicase
BRM78_RS00610	COG1187	pseudouridine synthase activity
BRM78_RS00620	COG0667	Aldo Keto reductase
BRM78_RS00625	COG2130	NADP-dependent
BRM78_RS00630	COG0656	L-ascorbic acid biosynthetic process
BRM78_RS00655	COG3039	Transposase
BRM78_RS00670	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRM78_RS00680	COG1119	ATPase activity
BRM78_RS00695	COG1125	glycine betaine transport
BRM78_RS00695	COG0517	IMP dehydrogenase activity
BRM78_RS00710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM78_RS00715	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRM78_RS00720	COG3550	peptidyl-serine autophosphorylation
BRM78_RS00725	COG1396	sequence-specific DNA binding
BRM78_RS00745	COG0489	protein tyrosine kinase activity
BRM78_RS00750	COG2062	phosphohistidine phosphatase, SixA
BRM78_RS00760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM78_RS00805	COG1968	undecaprenyl-diphosphatase activity
BRM78_RS00810	COG0174	glutamine synthetase
BRM78_RS00815	COG0347	Belongs to the P(II) protein family
BRM78_RS00820	COG0004	ammonium transporteR
BRM78_RS00825	COG3852	Histidine kinase
BRM78_RS00830	COG2204	response regulator
BRM78_RS00835	COG2032	superoxide dismutase activity
BRM78_RS00840	COG2032	superoxide dismutase activity
BRM78_RS00880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRM78_RS00885	COG1074	ATP-dependent DNA helicase activity
BRM78_RS00895	COG3549	Plasmid maintenance system killer
BRM78_RS00995	COG1764	response to oxidative stress
BRM78_RS01000	COG1846	Transcriptional regulator
BRM78_RS01050	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRM78_RS01095	COG2211	Major facilitator Superfamily
BRM78_RS01120	COG3693	PFAM glycoside hydrolase, family 10
BRM78_RS01145	COG0246	Mannitol dehydrogenase
BRM78_RS01150	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM78_RS01160	COG4948	Mandelate Racemase Muconate Lactonizing
BRM78_RS01170	COG3661	Belongs to the glycosyl hydrolase 67 family
BRM78_RS01225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRM78_RS01235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRM78_RS01245	COG0805	protein transport
BRM78_RS01255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRM78_RS01255	COG0519	Catalyzes the synthesis of GMP from XMP
BRM78_RS01280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM78_RS01295	COG0457	Tetratricopeptide repeat
BRM78_RS01300	COG4771	TonB-dependent receptor
BRM78_RS01315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRM78_RS01325	COG0697	spore germination
BRM78_RS01335	COG0523	cobalamin synthesis protein
BRM78_RS01390	COG1960	acyl-CoA dehydrogenase activity
BRM78_RS01395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRM78_RS01400	COG4770	biotin carboxylase activity
BRM78_RS01450	COG2072	flavoprotein involved in K transport
BRM78_RS01470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM78_RS01520	COG0084	hydrolase, TatD family'
BRM78_RS01540	COG0583	DNA-binding transcription factor activity
BRM78_RS01545	COG2814	Major facilitator Superfamily
BRM78_RS01555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRM78_RS01560	COG1902	pentaerythritol trinitrate reductase activity
BRM78_RS01590	COG0745	RESPONSE REGULATOR receiver
BRM78_RS01610	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM78_RS01615	COG0583	DNA-binding transcription factor activity
BRM78_RS01645	COG0702	epimerase
BRM78_RS01650	COG1733	regulation of RNA biosynthetic process
BRM78_RS01710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM78_RS01725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM78_RS01760	COG2911	Protein conserved in bacteria
BRM78_RS01765	COG0729	surface antigen
BRM78_RS01780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRM78_RS01785	COG3118	belongs to the thioredoxin family
BRM78_RS01795	COG2884	Cell division ATP-binding protein ftsE
BRM78_RS01800	COG2177	Part of the ABC transporter FtsEX involved in
BRM78_RS01805	COG3437	response regulator, receiver
BRM78_RS01810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRM78_RS01815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM78_RS01825	COG1252	NADH dehydrogenase
BRM78_RS01850	COG0459	protein refolding
BRM78_RS01860	COG4771	TonB-dependent receptor
BRM78_RS01875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRM78_RS01910	COG3386	PFAM SMP-30 Gluconolaconase
BRM78_RS01925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM78_RS01955	COG2353	YceI-like domain
BRM78_RS02055	COG0408	coproporphyrinogen oxidase activity
BRM78_RS02065	COG3039	Transposase
BRM78_RS02090	COG0129	dihydroxy-acid dehydratase activity
BRM78_RS02100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRM78_RS02155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRM78_RS02160	COG0318	PFAM AMP-dependent synthetase and ligase
BRM78_RS02165	COG0727	PFAM Uncharacterised protein family (UPF0153)
BRM78_RS02170	COG0596	Alpha beta hydrolase
BRM78_RS02185	COG3177	Filamentation induced by cAMP protein fic
BRM78_RS02190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM78_RS02205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRM78_RS02230	COG4191	Histidine kinase
BRM78_RS02235	COG0028	Belongs to the TPP enzyme family
BRM78_RS02250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRM78_RS02255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRM78_RS02300	COG5383	Protein conserved in bacteria
BRM78_RS02315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM78_RS02320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM78_RS02325	COG1473	amidohydrolase
BRM78_RS02335	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM78_RS02335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM78_RS02350	COG3328	transposase activity
BRM78_RS02365	COG3039	Transposase
BRM78_RS02445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRM78_RS02460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM78_RS02465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BRM78_RS02475	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BRM78_RS02480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRM78_RS02485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRM78_RS02535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRM78_RS02550	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRM78_RS02615	COG0358	DNA primase activity
BRM78_RS02620	COG1295	ribonuclease BN
BRM78_RS02635	COG1610	YqeY-like protein
BRM78_RS02645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRM78_RS02650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRM78_RS02690	COG2133	pyrroloquinoline quinone binding
BRM78_RS02695	COG4682	membrane
BRM78_RS02730	COG0531	amino acid
BRM78_RS02770	COG4948	Mandelate Racemase Muconate Lactonizing
BRM78_RS02780	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRM78_RS02785	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRM78_RS02820	COG3039	Transposase
BRM78_RS02875	COG0183	Belongs to the thiolase family
BRM78_RS02910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRM78_RS02920	COG3483	tryptophan 2,3-dioxygenase activity
BRM78_RS02925	COG3104	oligopeptide transport
BRM78_RS02945	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BRM78_RS02955	COG1320	monovalent cation:proton antiporter activity
BRM78_RS02960	COG2212	antiporter activity
BRM78_RS02970	COG0651	ATP synthesis coupled electron transport
BRM78_RS02975	COG1006	Multisubunit Na H antiporter MnhC subunit
BRM78_RS02980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM78_RS02980	COG2111	Na H antiporter
BRM78_RS03035	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRM78_RS03045	COG0456	acetyltransferase
BRM78_RS03075	COG4221	oxidoreductase activity
BRM78_RS03135	COG0697	spore germination
BRM78_RS03140	COG4305	rare lipoprotein A
BRM78_RS03145	COG5297	Belongs to the glycosyl hydrolase family 6
BRM78_RS03155	COG1113	amino acid transport
BRM78_RS03165	COG0598	Magnesium transport protein CorA
BRM78_RS03240	COG5297	Belongs to the glycosyl hydrolase family 6
BRM78_RS03240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM78_RS03245	COG0659	secondary active sulfate transmembrane transporter activity
BRM78_RS03290	COG3275	phosphorelay sensor kinase activity
BRM78_RS03300	COG0181	hydroxymethylbilane synthase activity
BRM78_RS03325	COG1505	serine-type exopeptidase activity
BRM78_RS03340	COG0436	Aminotransferase
BRM78_RS03370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRM78_RS03400	COG0308	aminopeptidase N
BRM78_RS03405	COG2199	diguanylate cyclase activity
BRM78_RS03450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM78_RS03455	COG1077	Cell shape determining protein MreB Mrl
BRM78_RS03460	COG1792	Involved in formation and maintenance of cell shape
BRM78_RS03475	COG0772	Belongs to the SEDS family
BRM78_RS03520	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRM78_RS03520	COG3409	Peptidoglycan-binding domain 1 protein
BRM78_RS03520	COG1388	LysM domain
BRM78_RS03535	COG2951	lytic endotransglycosylase activity
BRM78_RS03540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRM78_RS03550	COG1686	Belongs to the peptidase S11 family
BRM78_RS03565	COG2921	Belongs to the UPF0250 family
BRM78_RS03600	COG1051	belongs to the nudix hydrolase family
BRM78_RS03600	COG1056	cytidyltransferase-related domain
BRM78_RS03635	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRM78_RS03640	COG0673	inositol 2-dehydrogenase activity
BRM78_RS03645	COG2823	Periplasmic or secreted lipoprotein
BRM78_RS03650	COG4251	negative regulation of phosphorylation
BRM78_RS03655	COG0784	Response regulator, receiver
BRM78_RS03660	COG4191	Histidine kinase
BRM78_RS03665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRM78_RS03715	COG3250	beta-galactosidase activity
BRM78_RS03730	COG2188	Transcriptional regulator
BRM78_RS03740	COG1609	Transcriptional regulator
BRM78_RS03745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM78_RS03750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRM78_RS03760	COG1215	transferase activity, transferring glycosyl groups
BRM78_RS03765	COG1649	PFAM Uncharacterised BCR, COG1649
BRM78_RS03765	COG0726	polysaccharide deacetylase
BRM78_RS03815	COG3039	Transposase
BRM78_RS03870	COG3039	Transposase
BRM78_RS03885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM78_RS03890	COG3039	Transposase
BRM78_RS03925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRM78_RS03945	COG2205	protein histidine kinase activity
BRM78_RS03985	COG2205	protein histidine kinase activity
BRM78_RS04035	COG0488	(ABC) transporter
BRM78_RS04055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRM78_RS04075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM78_RS04075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM78_RS04095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRM78_RS04100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM78_RS04105	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRM78_RS04130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRM78_RS04135	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRM78_RS04145	COG2205	protein histidine kinase activity
BRM78_RS04150	COG0745	RESPONSE REGULATOR receiver
BRM78_RS04155	COG0277	FAD linked oxidase domain protein
BRM78_RS04160	COG1988	membrane-bound metal-dependent
BRM78_RS04165	COG0792	nuclease activity
BRM78_RS04200	COG0275	rRNA processing
BRM78_RS04205	COG3116	cell division
BRM78_RS04220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRM78_RS04225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRM78_RS04240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM78_RS04245	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRM78_RS04250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRM78_RS04265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRM78_RS04275	COG1388	LysM domain
BRM78_RS04275	COG4942	peptidase
BRM78_RS04290	COG0494	nUDIX hydrolase
BRM78_RS04305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRM78_RS04320	COG3321	synthase
BRM78_RS04320	COG0604	alcohol dehydrogenase
BRM78_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS04375	COG2226	methyltransferase
BRM78_RS04380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRM78_RS04435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRM78_RS04450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM78_RS04470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM78_RS04475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRM78_RS04485	COG0667	Aldo Keto reductase
BRM78_RS04535	COG2175	clavaminate synthase activity
BRM78_RS04545	COG4181	ATPase activity
BRM78_RS04560	COG0642	Histidine kinase
BRM78_RS04585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRM78_RS04605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRM78_RS04630	COG2967	ApaG domain
BRM78_RS04635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRM78_RS04645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRM78_RS04660	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRM78_RS04665	COG2096	Adenosyltransferase
BRM78_RS04675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM78_RS04680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM78_RS04720	COG0583	DNA-binding transcription factor activity
BRM78_RS04725	COG0318	PFAM AMP-dependent synthetase and ligase
BRM78_RS04735	COG1024	Enoyl-CoA hydratase
BRM78_RS04755	COG3386	PFAM SMP-30 Gluconolaconase
BRM78_RS04895	COG1902	pentaerythritol trinitrate reductase activity
BRM78_RS04895	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRM78_RS04900	COG0604	alcohol dehydrogenase
BRM78_RS04930	COG0156	8-amino-7-oxononanoate synthase activity
BRM78_RS04935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRM78_RS04940	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRM78_RS04945	COG4208	sulfate ABC transporter
BRM78_RS04950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRM78_RS04985	COG0406	alpha-ribazole phosphatase activity
BRM78_RS04995	COG0285	dihydrofolate synthase activity
BRM78_RS05015	COG2833	Protein of unknown function (DUF455)
BRM78_RS05035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM78_RS05040	COG0671	phosphoesterase, PA-phosphatase related
BRM78_RS05045	COG0438	transferase activity, transferring glycosyl groups
BRM78_RS05055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRM78_RS05070	COG4783	chaperone-mediated protein folding
BRM78_RS05150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM78_RS05160	COG0583	DNA-binding transcription factor activity
BRM78_RS05165	COG3634	alkyl hydroperoxide reductase activity
BRM78_RS05175	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM78_RS05220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM78_RS05220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM78_RS05235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRM78_RS05260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRM78_RS05290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRM78_RS05300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRM78_RS05330	COG1295	ribonuclease BN
BRM78_RS05335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM78_RS05355	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRM78_RS05365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRM78_RS05380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BRM78_RS05395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRM78_RS05405	COG0193	aminoacyl-tRNA hydrolase activity
BRM78_RS05410	COG0012	GTP binding
BRM78_RS05440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRM78_RS05445	COG0250	Participates in transcription elongation, termination and antitermination
BRM78_RS05455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRM78_RS05465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRM78_RS05470	COG0222	ribosome binding
BRM78_RS05475	COG0085	RNA polymerase activity
BRM78_RS05480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRM78_RS05485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRM78_RS05490	COG0049	tRNA binding
BRM78_RS05510	COG0051	transcription antitermination factor activity, RNA binding
BRM78_RS05515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRM78_RS05520	COG0088	Forms part of the polypeptide exit tunnel
BRM78_RS05525	COG0089	rRNA binding
BRM78_RS05540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRM78_RS05550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRM78_RS05555	COG0255	Belongs to the universal ribosomal protein uL29 family
BRM78_RS05560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRM78_RS05565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRM78_RS05575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRM78_RS05605	COG1841	ribosomal large subunit assembly
BRM78_RS05615	COG0201	protein transport
BRM78_RS05625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRM78_RS05630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRM78_RS05640	COG0203	ribosomal protein L17
BRM78_RS05705	COG3551	Protein conserved in bacteria
BRM78_RS05735	COG2194	sulfuric ester hydrolase activity
BRM78_RS05745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRM78_RS05750	COG0745	RESPONSE REGULATOR receiver
BRM78_RS05755	COG0642	Histidine kinase
BRM78_RS05765	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRM78_RS05770	COG2894	cell division
BRM78_RS05790	COG4585	Histidine kinase
BRM78_RS05795	COG2197	response regulator
BRM78_RS05810	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRM78_RS05840	COG2963	transposase activity
BRM78_RS05945	COG3039	Transposase
BRM78_RS06175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRM78_RS06195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRM78_RS06200	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRM78_RS06210	COG3039	Transposase
BRM78_RS06215	COG0732	type I restriction modification DNA specificity domain
BRM78_RS06220	COG3039	Transposase
BRM78_RS06245	COG3039	Transposase
BRM78_RS06250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRM78_RS06355	COG1297	OPT oligopeptide transporter protein
BRM78_RS06360	COG3039	Transposase
BRM78_RS06385	COG1506	peptidase
BRM78_RS06385	COG0823	Involved in the tonB-independent uptake of proteins
BRM78_RS06415	COG2207	Transcriptional regulator
BRM78_RS06415	COG1917	Cupin 2, conserved barrel domain protein
BRM78_RS06435	COG3039	Transposase
BRM78_RS06460	COG0753	catalase activity
BRM78_RS06505	COG0469	pyruvate kinase activity
BRM78_RS06510	COG3588	fructose-bisphosphate aldolase
BRM78_RS06515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRM78_RS06560	COG0784	Response regulator, receiver
BRM78_RS06560	COG2198	Histidine kinase
BRM78_RS06560	COG2205	protein histidine kinase activity
BRM78_RS06580	COG0175	sulfate reduction
BRM78_RS06585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRM78_RS06590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM78_RS06595	COG0175	sulfate reduction
BRM78_RS06600	COG0529	Catalyzes the synthesis of activated sulfate
BRM78_RS06600	COG2895	sulfate adenylyltransferase (ATP) activity
BRM78_RS06615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM78_RS06620	COG0308	aminopeptidase N
BRM78_RS06650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM78_RS06675	COG1970	mechanosensitive ion channel activity
BRM78_RS06705	COG3273	potassium ion transport
BRM78_RS06705	COG0471	metal ion transport
BRM78_RS06720	COG2022	thiamine diphosphate biosynthetic process
BRM78_RS06815	COG3039	Transposase
BRM78_RS06820	COG3039	Transposase
BRM78_RS06900	COG3118	belongs to the thioredoxin family
BRM78_RS06930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRM78_RS06955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRM78_RS06980	COG2968	Membrane
BRM78_RS06995	COG3164	Protein of unknown function
BRM78_RS07005	COG0312	modulator of DNA gyrase
BRM78_RS07010	COG3028	Belongs to the UPF0307 family
BRM78_RS07015	COG0312	modulator of DNA gyrase
BRM78_RS07040	COG0142	geranyltranstransferase activity
BRM78_RS07045	COG1722	exodeoxyribonuclease VII activity
BRM78_RS07050	COG0037	tRNA processing
BRM78_RS07055	COG1785	Belongs to the alkaline phosphatase family
BRM78_RS07060	COG1301	dicarboxylic acid transport
BRM78_RS07075	COG0791	NLP P60 protein
BRM78_RS07080	COG0791	NLP P60 protein
BRM78_RS07085	COG1047	Peptidyl-prolyl cis-trans
BRM78_RS07090	COG2311	Membrane
BRM78_RS07095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM78_RS07140	COG0489	protein tyrosine kinase activity
BRM78_RS07145	COG0717	Belongs to the dCTP deaminase family
BRM78_RS07165	COG0412	Dienelactone hydrolase
BRM78_RS07175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM78_RS07230	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM78_RS07235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRM78_RS07240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRM78_RS07245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRM78_RS07265	COG0101	tRNA pseudouridine synthase activity
BRM78_RS07270	COG0135	phosphoribosylanthranilate isomerase activity
BRM78_RS07295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRM78_RS07300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM78_RS07350	COG0149	triose-phosphate isomerase activity
BRM78_RS07365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM78_RS07375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM78_RS07380	COG0649	NAD binding
BRM78_RS07385	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRM78_RS07390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRM78_RS07395	COG1034	ATP synthesis coupled electron transport
BRM78_RS07430	COG1007	ATP synthesis coupled electron transport
BRM78_RS07440	COG0779	Required for maturation of 30S ribosomal subunits
BRM78_RS07445	COG0195	Participates in both transcription termination and antitermination
BRM78_RS07465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRM78_RS07470	COG1185	polyribonucleotide nucleotidyltransferase activity
BRM78_RS07505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM78_RS07515	COG2095	MarC family integral membrane protein
BRM78_RS07530	COG1611	Belongs to the LOG family
BRM78_RS07570	COG4969	Belongs to the N-Me-Phe pilin family
BRM78_RS07610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRM78_RS07680	COG0438	transferase activity, transferring glycosyl groups
BRM78_RS07685	COG0438	transferase activity, transferring glycosyl groups
BRM78_RS07695	COG0438	transferase activity, transferring glycosyl groups
BRM78_RS07735	COG3040	lipid binding
BRM78_RS07825	COG0784	Response regulator, receiver
BRM78_RS07825	COG4191	Histidine kinase
BRM78_RS07850	COG0552	protein localization to endoplasmic reticulum
BRM78_RS07860	COG3938	Belongs to the proline racemase family
BRM78_RS07865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM78_RS07880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM78_RS07890	COG0006	proline dipeptidase activity
BRM78_RS07905	COG0531	amino acid
BRM78_RS07955	COG4206	TonB-dependent receptor
BRM78_RS08060	COG0746	molybdenum cofactor guanylyltransferase activity
BRM78_RS08085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRM78_RS08085	COG1648	precorrin-2 dehydrogenase activity
BRM78_RS08115	COG3039	Transposase
BRM78_RS08120	COG3039	Transposase
BRM78_RS08160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRM78_RS08180	COG3039	Transposase
BRM78_RS08185	COG1054	Belongs to the UPF0176 family
BRM78_RS08205	COG1530	ribonuclease E activity
BRM78_RS08215	COG3064	Membrane
BRM78_RS08220	COG0428	transporter
BRM78_RS08225	COG0428	transporter
BRM78_RS08235	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRM78_RS08240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRM78_RS08240	COG0316	Belongs to the HesB IscA family
BRM78_RS08285	COG3039	Transposase
BRM78_RS08305	COG3039	Transposase
BRM78_RS08420	COG0631	protein serine/threonine phosphatase activity
BRM78_RS08425	COG0515	serine threonine protein kinase
BRM78_RS08455	COG1858	cytochrome C peroxidase
BRM78_RS08510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM78_RS08515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM78_RS08535	COG2201	protein-glutamate methylesterase activity
BRM78_RS08590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM78_RS08610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM78_RS08625	COG1595	DNA-templated transcription, initiation
BRM78_RS08675	COG2244	polysaccharide biosynthetic process
BRM78_RS08705	COG2264	protein methyltransferase activity
BRM78_RS08715	COG0438	transferase activity, transferring glycosyl groups
BRM78_RS08735	COG1136	(ABC) transporter
BRM78_RS08740	COG1132	(ABC) transporter
BRM78_RS08750	COG0477	Major facilitator Superfamily
BRM78_RS08770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRM78_RS08785	COG1253	flavin adenine dinucleotide binding
BRM78_RS08800	COG0306	phosphate transporter
BRM78_RS08805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BRM78_RS08830	COG0504	CTP synthase activity
BRM78_RS08835	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRM78_RS08845	COG0148	phosphopyruvate hydratase activity
BRM78_RS08850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRM78_RS08865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRM78_RS08880	COG2840	Smr protein MutS2
BRM78_RS08885	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRM78_RS08890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM78_RS08895	COG1238	metal cluster binding
BRM78_RS08910	COG1534	Rna-binding protein
BRM78_RS08915	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRM78_RS08925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRM78_RS08940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRM78_RS08945	COG1546	Belongs to the CinA family
BRM78_RS08960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRM78_RS08970	COG2137	regulation of response to DNA damage stimulus
BRM78_RS08975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRM78_RS08980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRM78_RS09005	COG0305	Participates in initiation and elongation during chromosome replication
BRM78_RS09010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRM78_RS09030	COG1741	Belongs to the pirin family
BRM78_RS09035	COG0583	DNA-binding transcription factor activity
BRM78_RS09065	COG0351	phosphomethylpyrimidine kinase
BRM78_RS09075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRM78_RS09080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRM78_RS09095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM78_RS09105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRM78_RS09110	COG3734	2-keto-3-deoxy-galactonokinase
BRM78_RS09120	COG4948	Mandelate Racemase Muconate Lactonizing
BRM78_RS09125	COG0800	Aldolase
BRM78_RS09140	COG1501	Belongs to the glycosyl hydrolase 31 family
BRM78_RS09150	COG1070	Carbohydrate kinase
BRM78_RS09160	COG0477	Major facilitator Superfamily
BRM78_RS09180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRM78_RS09230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRM78_RS09235	COG2258	MOSC domain
BRM78_RS09245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRM78_RS09250	COG0505	Belongs to the CarA family
BRM78_RS09260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRM78_RS09265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM78_RS09275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRM78_RS09350	COG0784	Response regulator, receiver
BRM78_RS09350	COG2198	Histidine kinase
BRM78_RS09350	COG2205	protein histidine kinase activity
BRM78_RS09355	COG1024	Enoyl-CoA hydratase
BRM78_RS09360	COG0318	PFAM AMP-dependent synthetase and ligase
BRM78_RS09390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM78_RS09425	COG0840	transmembrane signaling receptor activity
BRM78_RS09450	COG0835	chemotaxis
BRM78_RS09470	COG0840	transmembrane signaling receptor activity
BRM78_RS09475	COG0840	transmembrane signaling receptor activity
BRM78_RS09480	COG0840	transmembrane signaling receptor activity
BRM78_RS09485	COG0840	transmembrane signaling receptor activity
BRM78_RS09495	COG0840	transmembrane signaling receptor activity
BRM78_RS09505	COG0840	transmembrane signaling receptor activity
BRM78_RS09520	COG0840	transmembrane signaling receptor activity
BRM78_RS09545	COG0745	RESPONSE REGULATOR receiver
BRM78_RS09555	COG0835	chemotaxis
BRM78_RS09565	COG1360	Flagellar Motor Protein
BRM78_RS09570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRM78_RS09590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM78_RS09600	COG4771	TonB-dependent receptor
BRM78_RS09630	COG3039	Transposase
BRM78_RS09750	COG3039	Transposase
BRM78_RS09765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM78_RS09765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM78_RS09770	COG1105	Belongs to the carbohydrate kinase PfkB family
BRM78_RS09775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM78_RS09775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM78_RS09780	COG1609	Transcriptional regulator
BRM78_RS09800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM78_RS09805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM78_RS09815	COG2902	Dehydrogenase
BRM78_RS09825	COG3039	Transposase
BRM78_RS09835	COG0784	Response regulator, receiver
BRM78_RS09835	COG5002	protein histidine kinase activity
BRM78_RS09835	COG2205	protein histidine kinase activity
BRM78_RS09840	COG2733	membrane
BRM78_RS09850	COG1121	(ABC) transporter
BRM78_RS09855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRM78_RS09875	COG2223	nitrite transmembrane transporter activity
BRM78_RS09885	COG0243	molybdopterin cofactor binding
BRM78_RS09895	COG0477	Major facilitator Superfamily
BRM78_RS09905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM78_RS09910	COG0174	glutamine synthetase
BRM78_RS09950	COG3842	ATPase activity
BRM78_RS09960	COG1177	transmembrane transport
BRM78_RS09970	COG1012	belongs to the aldehyde dehydrogenase family
BRM78_RS09985	COG4535	Mg2 and Co2 transporter CorC
BRM78_RS10005	COG1702	phosphate starvation-inducible protein PhoH
BRM78_RS10030	COG0741	lytic transglycosylase activity
BRM78_RS10040	COG0723	plastoquinol--plastocyanin reductase activity
BRM78_RS10045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRM78_RS10050	COG2857	Cytochrome c1
BRM78_RS10055	COG0625	glutathione transferase activity
BRM78_RS10060	COG2969	positive regulation of protein catabolic process
BRM78_RS10105	COG3328	transposase activity
BRM78_RS10190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM78_RS10215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM78_RS10220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRM78_RS10220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRM78_RS10225	COG0802	atpase or kinase
BRM78_RS10230	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM78_RS10235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRM78_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS10280	COG2081	HI0933 family
BRM78_RS10285	COG4681	YaeQ
BRM78_RS10290	COG1671	Belongs to the UPF0178 family
BRM78_RS10300	COG0625	glutathione transferase activity
BRM78_RS10320	COG0513	Belongs to the DEAD box helicase family
BRM78_RS10325	COG0488	(ABC) transporter
BRM78_RS10350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM78_RS10355	COG0483	inositol monophosphate 1-phosphatase activity
BRM78_RS10370	COG3300	MHYT domain
BRM78_RS10370	COG5001	Diguanylate cyclase
BRM78_RS10375	COG1509	lysine 2,3-aminomutase activity
BRM78_RS10390	COG0402	S-adenosylhomocysteine deaminase activity
BRM78_RS10395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRM78_RS10425	COG4677	pectinesterase activity
BRM78_RS10440	COG3039	Transposase
BRM78_RS10480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRM78_RS10505	COG2166	iron-sulfur cluster assembly
BRM78_RS10520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRM78_RS10525	COG0137	argininosuccinate synthase activity
BRM78_RS10535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM78_RS10540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRM78_RS10555	COG0165	Argininosuccinate lyase
BRM78_RS10575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRM78_RS10610	COG1271	oxidase subunit
BRM78_RS10630	COG4988	ABC transporter
BRM78_RS10635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRM78_RS10735	COG3039	Transposase
BRM78_RS10775	COG0784	Response regulator, receiver
BRM78_RS10775	COG2198	Histidine kinase
BRM78_RS10775	COG0643	Histidine kinase
BRM78_RS10830	COG1684	flagellar biosynthetic protein fliR
BRM78_RS10850	COG3190	flagellar
BRM78_RS10900	COG1677	Flagellar hook-basal body complex protein FliE
BRM78_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS10945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM78_RS10965	COG2201	protein-glutamate methylesterase activity
BRM78_RS10995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRM78_RS11000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRM78_RS11040	COG4787	bacterial-type flagellum-dependent cell motility
BRM78_RS11050	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRM78_RS11055	COG1558	bacterial-type flagellum-dependent cell motility
BRM78_RS11065	COG0784	Response regulator, receiver
BRM78_RS11065	COG0835	chemotaxis
BRM78_RS11085	COG5002	protein histidine kinase activity
BRM78_RS11095	COG4585	Histidine kinase
BRM78_RS11100	COG5001	Diguanylate cyclase
BRM78_RS11125	COG0482	sulfurtransferase activity
BRM78_RS11140	COG0542	response to heat
BRM78_RS11165	COG0492	ferredoxin-NADP+ reductase activity
BRM78_RS11170	COG1674	ftsk spoiiie
BRM78_RS11195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRM78_RS11215	COG0038	chloride channel
BRM78_RS11220	COG0183	Belongs to the thiolase family
BRM78_RS11225	COG1024	Enoyl-CoA hydratase
BRM78_RS11225	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM78_RS11240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRM78_RS11250	COG1426	Protein conserved in bacteria
BRM78_RS11260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM78_RS11270	COG0303	'Molybdopterin
BRM78_RS11300	COG3039	Transposase
BRM78_RS11310	COG3039	Transposase
BRM78_RS11340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRM78_RS11360	COG0742	ribosomal rna small subunit methyltransferase
BRM78_RS11365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRM78_RS11380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRM78_RS11385	COG0405	Gamma-glutamyltransferase
BRM78_RS11475	COG0343	queuine tRNA-ribosyltransferase activity
BRM78_RS11480	COG1862	Preprotein translocase
BRM78_RS11485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM78_RS11490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM78_RS11525	COG3328	transposase activity
BRM78_RS11540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM78_RS11550	COG0704	Plays a role in the regulation of phosphate uptake
BRM78_RS11565	COG0573	inorganic phosphate transmembrane transporter activity
BRM78_RS11570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRM78_RS11610	COG3039	Transposase
BRM78_RS11625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRM78_RS11635	COG1024	Enoyl-CoA hydratase
BRM78_RS11645	COG0494	nUDIX hydrolase
BRM78_RS11690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM78_RS11690	COG0116	Belongs to the methyltransferase superfamily
BRM78_RS11715	COG0667	Aldo Keto reductase
BRM78_RS11725	COG2925	Exonuclease
BRM78_RS11750	COG0288	reversible hydration of carbon dioxide
BRM78_RS11785	COG0316	Belongs to the HesB IscA family
BRM78_RS11790	COG0360	Binds together with S18 to 16S ribosomal RNA
BRM78_RS11800	COG0359	binds to the 23S rRNA
BRM78_RS11810	COG3115	cell septum assembly
BRM78_RS11825	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRM78_RS11840	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRM78_RS11865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRM78_RS11875	COG2986	histidine ammonia-lyase
BRM78_RS11880	COG1228	amidohydrolase
BRM78_RS11925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRM78_RS11935	COG0077	Prephenate dehydratase
BRM78_RS11935	COG1605	Chorismate mutase
BRM78_RS11940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRM78_RS11980	COG4566	intracellular signal transduction
BRM78_RS12030	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM78_RS12035	COG1469	GTP cyclohydrolase I activity
BRM78_RS12045	COG0617	tRNA 3'-terminal CCA addition
BRM78_RS12095	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM78_RS12115	COG2203	Gaf domain
BRM78_RS12115	COG3706	GGDEF domain
BRM78_RS12115	COG5001	Diguanylate cyclase
BRM78_RS12115	COG4251	negative regulation of phosphorylation
BRM78_RS12205	COG0386	Belongs to the glutathione peroxidase family
BRM78_RS12285	COG2205	protein histidine kinase activity
BRM78_RS12285	COG5002	protein histidine kinase activity
BRM78_RS12285	COG0784	Response regulator, receiver
BRM78_RS12315	COG0800	Aldolase
BRM78_RS12320	COG0129	dihydroxy-acid dehydratase activity
BRM78_RS12325	COG0363	glucosamine-6-phosphate deaminase activity
BRM78_RS12335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM78_RS12350	COG0354	folic acid binding
BRM78_RS12365	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRM78_RS12380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRM78_RS12395	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRM78_RS12425	COG0811	peptide transport
BRM78_RS12440	COG1663	tetraacyldisaccharide 4'-kinase activity
BRM78_RS12450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRM78_RS12460	COG0322	excinuclease ABC activity
BRM78_RS12495	COG3328	transposase activity
BRM78_RS12520	COG3039	Transposase
BRM78_RS12535	COG2801	Transposase and inactivated derivatives
BRM78_RS12545	COG2201	protein-glutamate methylesterase activity
BRM78_RS12640	COG3039	Transposase
BRM78_RS12645	COG3039	Transposase
BRM78_RS12660	COG1278	Cold shock
BRM78_RS12670	COG3328	transposase activity
BRM78_RS12695	COG3039	Transposase
BRM78_RS12710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM78_RS12730	COG0557	exoribonuclease II activity
BRM78_RS12760	COG1960	acyl-CoA dehydrogenase activity
BRM78_RS12765	COG2226	methyltransferase
BRM78_RS12770	COG0646	methionine synthase
BRM78_RS12770	COG1410	methionine synthase
BRM78_RS12775	COG1410	methionine synthase
BRM78_RS12775	COG0646	methionine synthase
BRM78_RS12785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM78_RS12795	COG1609	Transcriptional regulator
BRM78_RS12810	COG2900	Belongs to the SlyX family
BRM78_RS12825	COG0386	Belongs to the glutathione peroxidase family
BRM78_RS12835	COG1725	Transcriptional regulator
BRM78_RS12840	COG1131	(ABC) transporter
BRM78_RS12920	COG2850	peptidyl-arginine hydroxylation
BRM78_RS12955	COG1132	(ABC) transporter
BRM78_RS12970	COG0583	DNA-binding transcription factor activity
BRM78_RS12990	COG0287	Prephenate dehydrogenase
BRM78_RS12990	COG1605	Chorismate mutase
BRM78_RS12995	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRM78_RS13005	COG0484	heat shock protein binding
BRM78_RS13010	COG0443	Heat shock 70 kDa protein
BRM78_RS13015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRM78_RS13025	COG0497	DNA recombination
BRM78_RS13035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM78_RS13045	COG2914	Belongs to the UPF0125 (RnfH) family
BRM78_RS13070	COG1960	acyl-CoA dehydrogenase activity
BRM78_RS13080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRM78_RS13125	COG2814	Major facilitator Superfamily
BRM78_RS13130	COG1566	PFAM secretion protein HlyD family protein
BRM78_RS13170	COG4774	siderophore transport
BRM78_RS13185	COG0367	asparagine synthase
BRM78_RS13200	COG1393	Belongs to the ArsC family
BRM78_RS13260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRM78_RS13275	COG0233	cytoplasmic translational termination
BRM78_RS13285	COG0575	Belongs to the CDS family
BRM78_RS13295	COG0750	zinc metalloprotease
BRM78_RS13315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM78_RS13320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM78_RS13340	COG0825	malonyl-CoA metabolic process
BRM78_RS13350	COG4771	TonB-dependent receptor
BRM78_RS13355	COG1131	(ABC) transporter
BRM78_RS13375	COG1981	membrane
BRM78_RS13420	COG2895	sulfate adenylyltransferase (ATP) activity
BRM78_RS13420	COG0529	Catalyzes the synthesis of activated sulfate
BRM78_RS13455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM78_RS13470	COG2040	homocysteine
BRM78_RS13475	COG0833	amino acid
BRM78_RS13495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM78_RS13495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM78_RS13505	COG2878	Part of a membrane complex involved in electron transport
BRM78_RS13525	COG1595	DNA-templated transcription, initiation
BRM78_RS13550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM78_RS13565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM78_RS13570	COG0251	oxidation-reduction process
BRM78_RS13580	COG0392	lysyltransferase activity
BRM78_RS13580	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRM78_RS13635	COG2814	Major facilitator Superfamily
BRM78_RS13640	COG1902	pentaerythritol trinitrate reductase activity
BRM78_RS13655	COG2824	Alkylphosphonate utilization operon protein PhnA
BRM78_RS13670	COG1047	Peptidyl-prolyl cis-trans
BRM78_RS13715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRM78_RS13730	COG1451	nucleotide metabolic process
BRM78_RS13755	COG0183	Belongs to the thiolase family
BRM78_RS13785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRM78_RS13785	COG1793	dna ligase
BRM78_RS13795	COG1793	dna ligase
BRM78_RS13800	COG1201	RNA secondary structure unwinding
BRM78_RS13820	COG1278	Cold shock
BRM78_RS13825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRM78_RS13830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BRM78_RS13840	COG3046	protein related to deoxyribodipyrimidine photolyase
BRM78_RS13845	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRM78_RS13850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRM78_RS13865	COG2954	triphosphatase activity
BRM78_RS13880	COG1381	Involved in DNA repair and RecF pathway recombination
BRM78_RS13910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM78_RS13925	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM78_RS13925	COG1024	Enoyl-CoA hydratase
BRM78_RS13945	COG1024	Enoyl-CoA hydratase
BRM78_RS13950	COG1960	acyl-CoA dehydrogenase activity
BRM78_RS14020	COG2353	YceI-like domain
BRM78_RS14030	COG2353	YceI-like domain
BRM78_RS14045	COG1760	l-serine dehydratase
BRM78_RS14055	COG0626	cystathionine gamma-synthase activity
BRM78_RS14060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM78_RS14065	COG0739	heme binding
BRM78_RS14075	COG1272	protein, Hemolysin III
BRM78_RS14095	COG0463	Glycosyl transferase, family 2
BRM78_RS14105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRM78_RS14115	COG4771	TonB-dependent receptor
BRM78_RS14120	COG1309	transcriptional regulator
BRM78_RS14130	COG1960	acyl-CoA dehydrogenase activity
BRM78_RS14165	COG0509	glycine decarboxylation via glycine cleavage system
BRM78_RS14180	COG0330	HflC and HflK could
BRM78_RS14195	COG3956	TIGRFAM MazG family protein
BRM78_RS14205	COG0494	nUDIX hydrolase
BRM78_RS14215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRM78_RS14220	COG0837	glucose binding
BRM78_RS14235	COG3858	chitin binding
BRM78_RS14235	COG1388	LysM domain
BRM78_RS14255	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM78_RS14285	COG3039	Transposase
BRM78_RS14335	COG3537	Alpha-1,2-mannosidase
BRM78_RS14395	COG3142	Participates in the control of copper homeostasis
BRM78_RS14400	COG1446	asparaginase
BRM78_RS14445	COG0784	Response regulator, receiver
BRM78_RS14445	COG2198	Histidine kinase
BRM78_RS14445	COG0643	Histidine kinase
BRM78_RS14450	COG0840	transmembrane signaling receptor activity
BRM78_RS14455	COG0835	chemotaxis
BRM78_RS14470	COG0189	ligase activity
BRM78_RS14480	COG1397	ADP-ribosylglycohydrolase
BRM78_RS14490	COG1199	ATP-dependent helicase activity
BRM78_RS14500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRM78_RS14505	COG1215	transferase activity, transferring glycosyl groups
BRM78_RS14515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM78_RS14570	COG1643	Atp-dependent helicase
BRM78_RS14575	COG0783	Belongs to the Dps family
BRM78_RS14585	COG0514	ATP-dependent DNA helicase (RecQ)
BRM78_RS14610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRM78_RS14670	COG1187	pseudouridine synthase activity
BRM78_RS14680	COG0602	queuosine metabolic process
BRM78_RS14690	COG2885	chlorophyll binding
BRM78_RS14705	COG0848	biopolymer transport protein
BRM78_RS14715	COG0824	Thioesterase
BRM78_RS14720	COG2255	four-way junction helicase activity
BRM78_RS14730	COG0632	four-way junction helicase activity
BRM78_RS14850	COG3209	COG3209 Rhs family protein
BRM78_RS14850	COG3209	COG3209 Rhs family protein
BRM78_RS14870	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRM78_RS14875	COG1845	cytochrome c oxidase, subunit III
BRM78_RS14880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRM78_RS14895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRM78_RS14900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRM78_RS14910	COG0196	riboflavin kinase activity
BRM78_RS14915	COG0728	peptidoglycan biosynthetic process
BRM78_RS14920	COG0268	Binds directly to 16S ribosomal RNA
BRM78_RS14925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRM78_RS14930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRM78_RS14940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRM78_RS14945	COG0824	Thioesterase
BRM78_RS14960	COG1946	Acyl-CoA thioesterase
BRM78_RS14970	COG1595	DNA-templated transcription, initiation
BRM78_RS14990	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BRM78_RS15030	COG1877	trehalose-phosphatase activity
BRM78_RS15035	COG3387	PFAM Glycoside hydrolase 15-related
BRM78_RS15060	COG0564	pseudouridine synthase activity
BRM78_RS15065	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM78_RS15070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRM78_RS15070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM78_RS15085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRM78_RS15090	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM78_RS15130	COG2194	sulfuric ester hydrolase activity
BRM78_RS15135	COG4969	Belongs to the N-Me-Phe pilin family
BRM78_RS15145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRM78_RS15190	COG3039	Transposase
BRM78_RS15205	COG3039	Transposase
BRM78_RS15230	COG1132	(ABC) transporter
BRM78_RS15260	COG0745	RESPONSE REGULATOR receiver
BRM78_RS15265	COG5000	phosphorelay sensor kinase activity
BRM78_RS15265	COG5002	protein histidine kinase activity
BRM78_RS15270	COG0475	glutathione-regulated potassium exporter activity
BRM78_RS15280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM78_RS15305	COG1187	pseudouridine synthase activity
BRM78_RS15310	COG5001	Diguanylate cyclase
BRM78_RS15310	COG5002	protein histidine kinase activity
BRM78_RS15370	COG3039	Transposase
BRM78_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS15435	COG0415	Belongs to the DNA photolyase family
BRM78_RS15440	COG0305	Participates in initiation and elongation during chromosome replication
BRM78_RS15450	COG0367	asparagine synthase
BRM78_RS15465	COG1960	acyl-CoA dehydrogenase activity
BRM78_RS15480	COG0084	hydrolase, TatD family'
BRM78_RS15485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRM78_RS15550	COG0735	belongs to the Fur family
BRM78_RS15555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRM78_RS15590	COG3039	Transposase
BRM78_RS15615	COG3039	Transposase
BRM78_RS15640	COG2205	protein histidine kinase activity
BRM78_RS15660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRM78_RS15670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRM78_RS15680	COG0643	Histidine kinase
BRM78_RS15680	COG2198	Histidine kinase
BRM78_RS15685	COG0840	transmembrane signaling receptor activity
BRM78_RS15690	COG0835	chemotaxis
BRM78_RS15695	COG2200	EAL domain
BRM78_RS15695	COG2202	Pas domain
BRM78_RS15695	COG2199	diguanylate cyclase activity
BRM78_RS15700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRM78_RS15715	COG3590	peptidase
BRM78_RS15735	COG1515	deoxyribonuclease V activity
BRM78_RS15745	COG1741	Belongs to the pirin family
BRM78_RS15860	COG1741	Belongs to the pirin family
BRM78_RS15865	COG1966	Carbon starvation protein
BRM78_RS15870	COG2879	small protein
BRM78_RS15910	COG3706	GGDEF domain
BRM78_RS15910	COG4251	negative regulation of phosphorylation
BRM78_RS15910	COG5001	Diguanylate cyclase
BRM78_RS15910	COG2203	Gaf domain
BRM78_RS15920	COG0629	single-stranded DNA binding
BRM78_RS15925	COG0142	geranyltranstransferase activity
BRM78_RS15955	COG0527	aspartate kinase activity
BRM78_RS15965	COG0384	phenazine biosynthesis protein PhzF
BRM78_RS15975	COG1764	response to oxidative stress
BRM78_RS15990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRM78_RS15995	COG1678	Uncharacterized ACR, COG1678
BRM78_RS16005	COG0519	Catalyzes the synthesis of GMP from XMP
BRM78_RS16040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRM78_RS16085	COG0693	protein deglycase activity
BRM78_RS16105	COG1959	2 iron, 2 sulfur cluster binding
BRM78_RS16110	COG0719	Fe-S assembly protein
BRM78_RS16115	COG0396	ATPase activity
BRM78_RS16120	COG0719	Fe-S assembly protein
BRM78_RS16125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRM78_RS16135	COG2146	nitrite reductase [NAD(P)H] activity
BRM78_RS16165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM78_RS16180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRM78_RS16190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRM78_RS16195	COG0174	glutamine synthetase
BRM78_RS16200	COG3328	transposase activity
BRM78_RS16235	COG2207	Transcriptional regulator
BRM78_RS16255	COG0657	acetylesterase activity
BRM78_RS16255	COG2755	lipolytic protein G-D-S-L family
BRM78_RS16280	COG0488	(ABC) transporter
BRM78_RS16315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRM78_RS16315	COG4651	solute:proton antiporter activity
BRM78_RS16330	COG4772	TonB-dependent receptor
BRM78_RS16340	COG4264	IucA IucC family
BRM78_RS16345	COG2814	Major facilitator Superfamily
BRM78_RS16355	COG0019	diaminopimelate decarboxylase activity
BRM78_RS16415	COG4206	TonB-dependent receptor
BRM78_RS16455	COG0542	response to heat
BRM78_RS16495	COG0534	Mate efflux family protein
BRM78_RS16510	COG0336	Belongs to the RNA methyltransferase TrmD family
BRM78_RS16515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRM78_RS16520	COG0228	four-way junction DNA binding
BRM78_RS16545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRM78_RS16555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM78_RS16605	COG1555	photosystem II stabilization
BRM78_RS16610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM78_RS16625	COG3178	'Phosphotransferase
BRM78_RS16630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRM78_RS16640	COG0628	permease
BRM78_RS16650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRM78_RS16665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRM78_RS16685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRM78_RS16695	COG0271	Belongs to the BolA IbaG family
BRM78_RS16705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRM78_RS16715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRM78_RS16720	COG1137	ATPase activity
BRM78_RS16735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM78_RS16740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRM78_RS16745	COG1660	Displays ATPase and GTPase activities
BRM78_RS16755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM78_RS16760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM78_RS16770	COG2239	Acts as a magnesium transporter
BRM78_RS16780	COG1294	oxidase, subunit
BRM78_RS16785	COG1271	oxidase subunit
BRM78_RS16805	COG1113	amino acid transport
BRM78_RS16820	COG2197	response regulator
BRM78_RS16825	COG0531	amino acid
BRM78_RS16895	COG0754	glutathionylspermidine amidase activity
BRM78_RS16920	COG1842	Phage shock protein A
BRM78_RS16935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRM78_RS17080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRM78_RS17085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM78_RS17125	COG0745	RESPONSE REGULATOR receiver
BRM78_RS17130	COG2205	protein histidine kinase activity
BRM78_RS17150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRM78_RS17185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM78_RS17185	COG3453	Protein conserved in bacteria
BRM78_RS17190	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRM78_RS17195	COG4149	molybdate abc transporter
BRM78_RS17200	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRM78_RS17220	COG0642	Histidine kinase
BRM78_RS17235	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS17245	COG1022	Amp-dependent synthetase and ligase
BRM78_RS17270	COG1376	ErfK ybiS ycfS ynhG family protein
BRM78_RS17275	COG0739	heme binding
BRM78_RS17285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRM78_RS17290	COG1301	dicarboxylic acid transport
BRM78_RS17310	COG2304	oxidoreductase activity
BRM78_RS17330	COG0714	Associated with various cellular activities
BRM78_RS17380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRM78_RS17405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRM78_RS17415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM78_RS17440	COG1561	YicC-like family, N-terminal region
BRM78_RS17445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRM78_RS17460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRM78_RS17495	COG0006	proline dipeptidase activity
BRM78_RS17520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRM78_RS17540	COG2912	Transglutaminase-like superfamily
BRM78_RS17545	COG1773	rubredoxin
BRM78_RS17550	COG0352	thiamine-phosphate diphosphorylase activity
BRM78_RS17585	COG0281	malic enzyme
BRM78_RS17585	COG0280	phosphate acetyltransferase
BRM78_RS17605	COG4191	Histidine kinase
BRM78_RS17620	COG0583	DNA-binding transcription factor activity
BRM78_RS17640	COG2197	response regulator
BRM78_RS17650	COG0642	Histidine kinase
BRM78_RS17670	COG2851	Citrate transporter
BRM78_RS17675	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS17680	COG1609	Transcriptional regulator
BRM78_RS17690	COG2211	Major facilitator Superfamily
BRM78_RS17740	COG0726	polysaccharide deacetylase
BRM78_RS17745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM78_RS17775	COG3039	Transposase
BRM78_RS17825	COG0242	peptide deformylase activity
BRM78_RS17845	COG0714	Associated with various cellular activities
BRM78_RS17865	COG0537	adenosine 5'-monophosphoramidase activity
BRM78_RS17895	COG0314	molybdopterin synthase activity
BRM78_RS17900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRM78_RS17905	COG0315	cyclic pyranopterin monophosphate synthase activity
BRM78_RS17915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRM78_RS17920	COG1234	tRNA 3'-trailer cleavage
BRM78_RS17925	COG3642	lipopolysaccharide core region biosynthetic process
BRM78_RS17930	COG0859	PFAM glycosyl transferase family 9
BRM78_RS17940	COG0582	viral genome integration into host DNA
BRM78_RS18025	COG0631	protein serine/threonine phosphatase activity
BRM78_RS18035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM78_RS18060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRM78_RS18100	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRM78_RS18155	COG0473	3-isopropylmalate dehydrogenase activity
BRM78_RS18180	COG0584	glycerophosphoryl diester phosphodiesterase
BRM78_RS18205	COG3039	Transposase
BRM78_RS18340	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRM78_RS18360	COG1217	gtp-binding protein TYPA
BRM78_RS18365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRM78_RS18375	COG0625	glutathione transferase activity
BRM78_RS18395	COG3781	membrane
BRM78_RS18405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM78_RS18435	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRM78_RS18455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRM78_RS18480	COG3710	Transcriptional regulator
BRM78_RS18485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRM78_RS18495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRM78_RS18530	COG0066	3-isopropylmalate dehydratase activity
BRM78_RS18535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRM78_RS18560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM78_RS18565	COG1538	Outer membrane efflux protein
BRM78_RS18570	COG1519	Transferase
BRM78_RS18575	COG1560	Kdo2-lipid A biosynthetic process
BRM78_RS18625	COG0308	aminopeptidase N
BRM78_RS18640	COG0330	HflC and HflK could
BRM78_RS18645	COG0330	HflC and HflK could
BRM78_RS18665	COG0678	peroxiredoxin activity
BRM78_RS18675	COG2826	transposase and inactivated derivatives, IS30 family
BRM78_RS18735	COG3039	Transposase
BRM78_RS18770	COG3829	transcription factor binding
BRM78_RS18805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRM78_RS18810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRM78_RS18820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM78_RS18825	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS18850	COG1399	metal-binding, possibly nucleic acid-binding protein
BRM78_RS18895	COG1518	maintenance of DNA repeat elements
BRM78_RS18900	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRM78_RS18955	COG2188	Transcriptional regulator
BRM78_RS18970	COG1450	Type ii and iii secretion system protein
BRM78_RS18985	COG3166	PFAM Fimbrial assembly family protein
BRM78_RS18990	COG3156	type II secretion system protein K
BRM78_RS18995	COG4795	General secretion pathway protein
BRM78_RS19000	COG2165	general secretion pathway protein
BRM78_RS19005	COG4970	Tfp pilus assembly protein FimT
BRM78_RS19010	COG2165	general secretion pathway protein
BRM78_RS19015	COG1459	type II secretion system
BRM78_RS19025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM78_RS19045	COG5295	Hep Hag repeat protein
BRM78_RS19055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRM78_RS19055	COG0047	phosphoribosylformylglycinamidine synthase activity
BRM78_RS19060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRM78_RS19065	COG4974	Belongs to the 'phage' integrase family
BRM78_RS19080	COG3039	Transposase
BRM78_RS19090	COG0795	lipopolysaccharide-transporting ATPase activity
BRM78_RS19100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM78_RS19115	COG0525	valine-tRNA ligase activity
BRM78_RS19185	COG3039	Transposase
BRM78_RS19210	COG1183	phosphatidylcholine synthase activity
BRM78_RS19220	COG0442	prolyl-tRNA aminoacylation
BRM78_RS19235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM78_RS19240	COG1127	ABC transporter
BRM78_RS19245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM78_RS19245	COG3218	ABC-type transport auxiliary lipoprotein component
BRM78_RS19285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM78_RS19290	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRM78_RS19290	COG0662	Cupin 2, conserved barrel domain protein
BRM78_RS19315	COG2086	electron transfer activity
BRM78_RS19340	COG3328	transposase activity
BRM78_RS19390	COG0626	cystathionine gamma-synthase activity
BRM78_RS19435	COG0513	Belongs to the DEAD box helicase family
BRM78_RS19445	COG0720	synthase
BRM78_RS19455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRM78_RS19460	COG1956	GAF domain-containing protein
BRM78_RS19500	COG0339	signal peptide processing
BRM78_RS19525	COG3039	Transposase
BRM78_RS19560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM78_RS19565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM78_RS19625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRM78_RS19630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRM78_RS19635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRM78_RS19645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRM78_RS19655	COG0356	it plays a direct role in the translocation of protons across the membrane
BRM78_RS19675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRM78_RS19685	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRM78_RS19715	COG2011	ABC-type metal ion transport system permease component
BRM78_RS19725	COG0697	spore germination
BRM78_RS19760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRM78_RS19765	COG1187	pseudouridine synthase activity
BRM78_RS19770	COG2813	Specifically methylates the guanine in position
BRM78_RS19805	COG2205	protein histidine kinase activity
BRM78_RS19805	COG2202	Pas domain
BRM78_RS19830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM78_RS19880	COG0745	RESPONSE REGULATOR receiver
BRM78_RS19895	COG1404	Belongs to the peptidase S8 family
BRM78_RS19910	COG0842	Transport permease protein
BRM78_RS19915	COG1131	(ABC) transporter
BRM78_RS19920	COG0025	NhaP-type Na H and K H
BRM78_RS19935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRM78_RS19945	COG1573	uracil-dna glycosylase
BRM78_RS19955	COG3384	dioxygenase
BRM78_RS19970	COG0667	Aldo Keto reductase
BRM78_RS19985	COG3590	peptidase
BRM78_RS20005	COG0531	amino acid
BRM78_RS20020	COG2972	Histidine kinase
BRM78_RS20050	COG2204	response regulator
BRM78_RS20065	COG1271	oxidase subunit
BRM78_RS20070	COG1294	oxidase, subunit
BRM78_RS20225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM78_RS20235	COG1560	Kdo2-lipid A biosynthetic process
BRM78_RS20285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRM78_RS20285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM78_RS20290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRM78_RS20295	COG0242	peptide deformylase activity
BRM78_RS20300	COG1652	LysM domain
BRM78_RS20305	COG0758	DNA mediated transformation
BRM78_RS20310	COG2922	Belongs to the Smg family
BRM78_RS20325	COG1754	DNA topoisomerase type I activity
BRM78_RS20325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRM78_RS20330	COG0009	L-threonylcarbamoyladenylate synthase
BRM78_RS20345	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS20355	COG0616	signal peptide processing
BRM78_RS20360	COG0534	Mate efflux family protein
BRM78_RS20385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRM78_RS20420	COG1324	tolerance protein
BRM78_RS20440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRM78_RS20445	COG0511	ligase activity, forming carbon-carbon bonds
BRM78_RS20455	COG0439	Biotin carboxylase
BRM78_RS20515	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRM78_RS20530	COG2453	phosphatase
BRM78_RS20530	COG0671	phosphoesterase, PA-phosphatase related
BRM78_RS20535	COG2267	carboxylic ester hydrolase activity
BRM78_RS20545	COG2267	carboxylic ester hydrolase activity
BRM78_RS20560	COG0419	ATPase involved in DNA repair
BRM78_RS20570	COG0151	Belongs to the GarS family
BRM78_RS20575	COG1136	(ABC) transporter
BRM78_RS20575	COG0577	efflux transmembrane transporter activity
BRM78_RS20585	COG1289	transmembrane transporter activity
BRM78_RS20600	COG2814	Major facilitator Superfamily
BRM78_RS20625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRM78_RS20660	COG0745	RESPONSE REGULATOR receiver
BRM78_RS20705	COG0739	heme binding
BRM78_RS20720	COG2211	Major facilitator Superfamily
BRM78_RS20725	COG0708	Exodeoxyribonuclease III
BRM78_RS20740	COG1192	Involved in chromosome partitioning
BRM78_RS20745	COG1475	DNA binding
BRM78_RS20760	COG0463	Glycosyl transferase, family 2
BRM78_RS20785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRM78_RS20790	COG2003	Belongs to the UPF0758 family
BRM78_RS20810	COG4221	oxidoreductase activity
BRM78_RS20840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRM78_RS20845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM78_RS20860	COG3485	protocatechuate 3,4-dioxygenase
BRM78_RS20865	COG3485	protocatechuate 3,4-dioxygenase
BRM78_RS20900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM78_RS20910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM78_RS20920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRM78_RS20920	COG1042	CoA-binding domain protein
BRM78_RS20920	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM78_RS20930	COG2239	Acts as a magnesium transporter
BRM78_RS20950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM78_RS20970	COG3100	YcgL domain-containing protein
BRM78_RS20975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRM78_RS20985	COG0463	Glycosyl transferase, family 2
BRM78_RS21000	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS21015	COG0156	8-amino-7-oxononanoate synthase activity
BRM78_RS21020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRM78_RS21025	COG1040	competence protein
BRM78_RS21030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRM78_RS21045	COG0628	permease
BRM78_RS21055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM78_RS21065	COG1595	DNA-templated transcription, initiation
BRM78_RS21070	COG0753	catalase activity
BRM78_RS21115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM78_RS21120	COG0180	Tryptophanyl-tRNA synthetase
BRM78_RS21125	COG3237	CsbD-like
BRM78_RS21165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRM78_RS21180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRM78_RS21185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRM78_RS21185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRM78_RS21225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM78_RS21255	COG1566	PFAM secretion protein HlyD family protein
BRM78_RS21275	COG1199	ATP-dependent helicase activity
BRM78_RS21310	COG0583	DNA-binding transcription factor activity
BRM78_RS21360	COG0625	glutathione transferase activity
BRM78_RS21400	COG4555	ABC transporter
BRM78_RS21410	COG1476	TRANSCRIPTIONal
BRM78_RS21430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM78_RS21435	COG1131	(ABC) transporter
BRM78_RS21440	COG0842	Transport permease protein
BRM78_RS21450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRM78_RS21550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM78_RS21560	COG0564	pseudouridine synthase activity
BRM78_RS21590	COG0339	signal peptide processing
BRM78_RS21620	COG3254	rhamnose metabolic process
BRM78_RS21625	COG0738	Major facilitator superfamily
BRM78_RS21630	COG1414	Transcriptional regulator
BRM78_RS21640	COG2205	protein histidine kinase activity
BRM78_RS21655	COG3459	Glycosyltransferase 36 associated
BRM78_RS21660	COG2211	Major facilitator Superfamily
BRM78_RS21665	COG3265	gluconokinase activity
BRM78_RS21680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM78_RS21730	COG3039	Transposase
BRM78_RS21765	COG1127	ABC transporter
BRM78_RS21770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM78_RS21775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM78_RS21790	COG2853	Lipoprotein
BRM78_RS21815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRM78_RS21880	COG0676	glucose-6-phosphate 1-epimerase activity
BRM78_RS21885	COG3039	Transposase
BRM78_RS21910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM78_RS21920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM78_RS21930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM78_RS21940	COG1064	alcohol dehydrogenase
BRM78_RS21985	COG1522	sequence-specific DNA binding
BRM78_RS21990	COG3186	Phenylalanine-4-hydroxylase
BRM78_RS22005	COG2755	lipolytic protein G-D-S-L family
BRM78_RS22035	COG2937	Belongs to the GPAT DAPAT family
BRM78_RS22070	COG0284	orotidine-5'-phosphate decarboxylase activity
BRM78_RS22075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRM78_RS22080	COG3132	Protein of unknown function, DUF480
BRM78_RS22095	COG0210	DNA helicase
BRM78_RS22110	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRM78_RS22135	COG1028	Short-chain dehydrogenase reductase Sdr
BRM78_RS22160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM78_RS22225	COG1166	arginine decarboxylase activity
BRM78_RS22230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRM78_RS22275	COG0606	chelatase, subunit chli
BRM78_RS22330	COG0366	Alpha amylase catalytic
BRM78_RS22335	COG0366	Alpha amylase catalytic
BRM78_RS22370	COG1609	Transcriptional regulator
BRM78_RS22410	COG0493	'glutamate synthase
BRM78_RS22415	COG0070	glutamate synthase
BRM78_RS22415	COG0067	glutamate synthase
BRM78_RS22415	COG0069	glutamate synthase activity
BRM78_RS22480	COG1205	dead DEAH box helicase
BRM78_RS22480	COG1111	helicase
BRM78_RS22485	COG1272	protein, Hemolysin III
BRM78_RS22530	COG1136	(ABC) transporter
BRM78_RS22595	COG2826	transposase and inactivated derivatives, IS30 family
BRM78_RS22620	COG3039	Transposase
BRM78_RS22630	COG1090	epimerase
BRM78_RS22640	COG0642	Histidine kinase
BRM78_RS22650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM78_RS22685	COG3039	Transposase
BRM78_RS22695	COG3039	Transposase
BRM78_RS22775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRM78_RS22855	COG1511	domain protein
BRM78_RS22855	COG3264	Mechanosensitive ion channel
BRM78_RS22870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM78_RS22880	COG2354	Protein conserved in bacteria
BRM78_RS22885	COG1649	PFAM Uncharacterised BCR, COG1649
BRM78_RS22905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRM78_RS22930	COG0702	epimerase
BRM78_RS22940	COG1858	cytochrome C peroxidase
BRM78_RS23045	COG0513	Belongs to the DEAD box helicase family
BRM78_RS23055	COG3039	Transposase
BRM78_RS23105	COG1136	(ABC) transporter
BRM78_RS23110	COG3039	Transposase
BRM78_RS23120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM78_RS23145	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRM78_RS23150	COG1304	FMN binding
BRM78_RS23155	COG3039	Transposase
BRM78_RS23170	COG4772	TonB-dependent receptor
BRM78_RS23180	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRM78_RS23190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM78_RS23230	COG0501	Belongs to the peptidase M48B family
BRM78_RS23240	COG0187	DNA topoisomerase II activity
BRM78_RS23260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids