locus-tag	class	description
BRM84_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRM84_RS00030	COG0187	DNA topoisomerase II activity
BRM84_RS00040	COG0501	Belongs to the peptidase M48B family
BRM84_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM84_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRM84_RS00100	COG4772	TonB-dependent receptor
BRM84_RS00115	COG3039	Transposase
BRM84_RS00120	COG1304	FMN binding
BRM84_RS00125	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRM84_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM84_RS00160	COG3039	Transposase
BRM84_RS00165	COG1136	(ABC) transporter
BRM84_RS00215	COG3039	Transposase
BRM84_RS00225	COG0513	Belongs to the DEAD box helicase family
BRM84_RS00330	COG1858	cytochrome C peroxidase
BRM84_RS00340	COG0702	epimerase
BRM84_RS00365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRM84_RS00385	COG1649	PFAM Uncharacterised BCR, COG1649
BRM84_RS00390	COG2354	Protein conserved in bacteria
BRM84_RS00400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM84_RS00415	COG1511	domain protein
BRM84_RS00415	COG3264	Mechanosensitive ion channel
BRM84_RS00495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRM84_RS00575	COG3039	Transposase
BRM84_RS00585	COG3039	Transposase
BRM84_RS00620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM84_RS00630	COG0642	Histidine kinase
BRM84_RS00640	COG1090	epimerase
BRM84_RS00650	COG3039	Transposase
BRM84_RS00675	COG2826	transposase and inactivated derivatives, IS30 family
BRM84_RS00735	COG1136	(ABC) transporter
BRM84_RS00780	COG1272	protein, Hemolysin III
BRM84_RS00785	COG1205	dead DEAH box helicase
BRM84_RS00785	COG1111	helicase
BRM84_RS00850	COG0067	glutamate synthase
BRM84_RS00850	COG0069	glutamate synthase activity
BRM84_RS00850	COG0070	glutamate synthase
BRM84_RS00855	COG0493	'glutamate synthase
BRM84_RS00895	COG1609	Transcriptional regulator
BRM84_RS00930	COG0366	Alpha amylase catalytic
BRM84_RS00935	COG0366	Alpha amylase catalytic
BRM84_RS00990	COG0606	chelatase, subunit chli
BRM84_RS01035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRM84_RS01040	COG1166	arginine decarboxylase activity
BRM84_RS01105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM84_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS01155	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRM84_RS01170	COG0210	DNA helicase
BRM84_RS01185	COG3132	Protein of unknown function, DUF480
BRM84_RS01190	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRM84_RS01195	COG0284	orotidine-5'-phosphate decarboxylase activity
BRM84_RS01230	COG2937	Belongs to the GPAT DAPAT family
BRM84_RS01260	COG2755	lipolytic protein G-D-S-L family
BRM84_RS01275	COG3186	Phenylalanine-4-hydroxylase
BRM84_RS01280	COG1522	sequence-specific DNA binding
BRM84_RS01325	COG1064	alcohol dehydrogenase
BRM84_RS01335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM84_RS01345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM84_RS01355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM84_RS01380	COG3039	Transposase
BRM84_RS01385	COG0676	glucose-6-phosphate 1-epimerase activity
BRM84_RS01450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRM84_RS01475	COG2853	Lipoprotein
BRM84_RS01490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM84_RS01495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM84_RS01500	COG1127	ABC transporter
BRM84_RS01535	COG3039	Transposase
BRM84_RS01585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM84_RS01600	COG3265	gluconokinase activity
BRM84_RS01605	COG2211	Major facilitator Superfamily
BRM84_RS01610	COG3459	Glycosyltransferase 36 associated
BRM84_RS01625	COG2205	protein histidine kinase activity
BRM84_RS01635	COG1414	Transcriptional regulator
BRM84_RS01640	COG0738	Major facilitator superfamily
BRM84_RS01645	COG3254	rhamnose metabolic process
BRM84_RS01675	COG0339	signal peptide processing
BRM84_RS01705	COG0564	pseudouridine synthase activity
BRM84_RS01715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM84_RS01815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRM84_RS01825	COG0842	Transport permease protein
BRM84_RS01830	COG1131	(ABC) transporter
BRM84_RS01835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM84_RS01855	COG1476	TRANSCRIPTIONal
BRM84_RS01865	COG4555	ABC transporter
BRM84_RS01905	COG0625	glutathione transferase activity
BRM84_RS01955	COG0583	DNA-binding transcription factor activity
BRM84_RS01990	COG1199	ATP-dependent helicase activity
BRM84_RS02010	COG1566	PFAM secretion protein HlyD family protein
BRM84_RS02040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM84_RS02080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRM84_RS02080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRM84_RS02085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRM84_RS02100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRM84_RS02140	COG3237	CsbD-like
BRM84_RS02145	COG0180	Tryptophanyl-tRNA synthetase
BRM84_RS02150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM84_RS02200	COG0753	catalase activity
BRM84_RS02205	COG1595	DNA-templated transcription, initiation
BRM84_RS02215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM84_RS02225	COG0628	permease
BRM84_RS02240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRM84_RS02245	COG1040	competence protein
BRM84_RS02250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRM84_RS02255	COG0156	8-amino-7-oxononanoate synthase activity
BRM84_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS02285	COG0463	Glycosyl transferase, family 2
BRM84_RS02295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRM84_RS02300	COG3100	YcgL domain-containing protein
BRM84_RS02320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM84_RS02340	COG2239	Acts as a magnesium transporter
BRM84_RS02350	COG1042	CoA-binding domain protein
BRM84_RS02350	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM84_RS02350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRM84_RS02360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM84_RS02370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM84_RS02405	COG3485	protocatechuate 3,4-dioxygenase
BRM84_RS02410	COG3485	protocatechuate 3,4-dioxygenase
BRM84_RS02425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM84_RS02430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRM84_RS02460	COG4221	oxidoreductase activity
BRM84_RS02480	COG2003	Belongs to the UPF0758 family
BRM84_RS02485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRM84_RS02510	COG0463	Glycosyl transferase, family 2
BRM84_RS02525	COG1475	DNA binding
BRM84_RS02530	COG1192	Involved in chromosome partitioning
BRM84_RS02545	COG0708	Exodeoxyribonuclease III
BRM84_RS02550	COG2211	Major facilitator Superfamily
BRM84_RS02565	COG0739	heme binding
BRM84_RS02615	COG0745	RESPONSE REGULATOR receiver
BRM84_RS02655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRM84_RS02680	COG2814	Major facilitator Superfamily
BRM84_RS02695	COG1289	transmembrane transporter activity
BRM84_RS02705	COG0577	efflux transmembrane transporter activity
BRM84_RS02705	COG1136	(ABC) transporter
BRM84_RS02710	COG0151	Belongs to the GarS family
BRM84_RS02720	COG0419	ATPase involved in DNA repair
BRM84_RS02735	COG2267	carboxylic ester hydrolase activity
BRM84_RS02745	COG2267	carboxylic ester hydrolase activity
BRM84_RS02750	COG2453	phosphatase
BRM84_RS02750	COG0671	phosphoesterase, PA-phosphatase related
BRM84_RS02765	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRM84_RS02825	COG0439	Biotin carboxylase
BRM84_RS02835	COG0511	ligase activity, forming carbon-carbon bonds
BRM84_RS02840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRM84_RS02860	COG1324	tolerance protein
BRM84_RS02895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRM84_RS02925	COG0534	Mate efflux family protein
BRM84_RS02930	COG0616	signal peptide processing
BRM84_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS02955	COG0009	L-threonylcarbamoyladenylate synthase
BRM84_RS02960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRM84_RS02960	COG1754	DNA topoisomerase type I activity
BRM84_RS02975	COG2922	Belongs to the Smg family
BRM84_RS02980	COG0758	DNA mediated transformation
BRM84_RS02985	COG1652	LysM domain
BRM84_RS02990	COG0242	peptide deformylase activity
BRM84_RS02995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRM84_RS03000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM84_RS03000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRM84_RS03050	COG1560	Kdo2-lipid A biosynthetic process
BRM84_RS03060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM84_RS03215	COG1294	oxidase, subunit
BRM84_RS03220	COG1271	oxidase subunit
BRM84_RS03235	COG2204	response regulator
BRM84_RS03265	COG2972	Histidine kinase
BRM84_RS03280	COG0531	amino acid
BRM84_RS03300	COG3590	peptidase
BRM84_RS03315	COG0667	Aldo Keto reductase
BRM84_RS03330	COG3384	dioxygenase
BRM84_RS03340	COG1573	uracil-dna glycosylase
BRM84_RS03350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRM84_RS03365	COG0025	NhaP-type Na H and K H
BRM84_RS03370	COG1131	(ABC) transporter
BRM84_RS03375	COG0842	Transport permease protein
BRM84_RS03390	COG1404	Belongs to the peptidase S8 family
BRM84_RS03405	COG0745	RESPONSE REGULATOR receiver
BRM84_RS03455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM84_RS03480	COG2202	Pas domain
BRM84_RS03480	COG2205	protein histidine kinase activity
BRM84_RS03515	COG2813	Specifically methylates the guanine in position
BRM84_RS03520	COG1187	pseudouridine synthase activity
BRM84_RS03525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRM84_RS03560	COG0697	spore germination
BRM84_RS03570	COG2011	ABC-type metal ion transport system permease component
BRM84_RS03600	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRM84_RS03610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRM84_RS03630	COG0356	it plays a direct role in the translocation of protons across the membrane
BRM84_RS03640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRM84_RS03650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRM84_RS03655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRM84_RS03660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRM84_RS03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM84_RS03725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM84_RS03760	COG3039	Transposase
BRM84_RS03785	COG0339	signal peptide processing
BRM84_RS03825	COG1956	GAF domain-containing protein
BRM84_RS03830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRM84_RS03840	COG0720	synthase
BRM84_RS03850	COG0513	Belongs to the DEAD box helicase family
BRM84_RS03895	COG0626	cystathionine gamma-synthase activity
BRM84_RS03945	COG3328	transposase activity
BRM84_RS03970	COG2086	electron transfer activity
BRM84_RS03995	COG0662	Cupin 2, conserved barrel domain protein
BRM84_RS03995	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRM84_RS04000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM84_RS04040	COG3218	ABC-type transport auxiliary lipoprotein component
BRM84_RS04040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM84_RS04045	COG1127	ABC transporter
BRM84_RS04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM84_RS04065	COG0442	prolyl-tRNA aminoacylation
BRM84_RS04075	COG1183	phosphatidylcholine synthase activity
BRM84_RS04105	COG3039	Transposase
BRM84_RS04175	COG0525	valine-tRNA ligase activity
BRM84_RS04190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM84_RS04200	COG0795	lipopolysaccharide-transporting ATPase activity
BRM84_RS04210	COG3039	Transposase
BRM84_RS04225	COG4974	Belongs to the 'phage' integrase family
BRM84_RS04230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRM84_RS04235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRM84_RS04235	COG0047	phosphoribosylformylglycinamidine synthase activity
BRM84_RS04245	COG5295	Hep Hag repeat protein
BRM84_RS04265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM84_RS04275	COG1459	type II secretion system
BRM84_RS04280	COG2165	general secretion pathway protein
BRM84_RS04285	COG4970	Tfp pilus assembly protein FimT
BRM84_RS04290	COG2165	general secretion pathway protein
BRM84_RS04295	COG4795	General secretion pathway protein
BRM84_RS04300	COG3156	type II secretion system protein K
BRM84_RS04305	COG3166	PFAM Fimbrial assembly family protein
BRM84_RS04320	COG1450	Type ii and iii secretion system protein
BRM84_RS04335	COG2188	Transcriptional regulator
BRM84_RS04390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRM84_RS04395	COG1518	maintenance of DNA repeat elements
BRM84_RS04440	COG1399	metal-binding, possibly nucleic acid-binding protein
BRM84_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS04470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM84_RS04480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRM84_RS04485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRM84_RS04520	COG3829	transcription factor binding
BRM84_RS04555	COG3039	Transposase
BRM84_RS04615	COG2826	transposase and inactivated derivatives, IS30 family
BRM84_RS04625	COG0678	peroxiredoxin activity
BRM84_RS04645	COG0330	HflC and HflK could
BRM84_RS04650	COG0330	HflC and HflK could
BRM84_RS04665	COG0308	aminopeptidase N
BRM84_RS04715	COG1560	Kdo2-lipid A biosynthetic process
BRM84_RS04720	COG1519	Transferase
BRM84_RS04725	COG1538	Outer membrane efflux protein
BRM84_RS04730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM84_RS04755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRM84_RS04760	COG0066	3-isopropylmalate dehydratase activity
BRM84_RS04795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRM84_RS04805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRM84_RS04810	COG3710	Transcriptional regulator
BRM84_RS04835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRM84_RS04855	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRM84_RS04885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM84_RS04895	COG3781	membrane
BRM84_RS04915	COG0625	glutathione transferase activity
BRM84_RS04925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRM84_RS04930	COG1217	gtp-binding protein TYPA
BRM84_RS04950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRM84_RS05085	COG3039	Transposase
BRM84_RS05110	COG0584	glycerophosphoryl diester phosphodiesterase
BRM84_RS05135	COG0473	3-isopropylmalate dehydrogenase activity
BRM84_RS05190	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRM84_RS05230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRM84_RS05255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM84_RS05265	COG0631	protein serine/threonine phosphatase activity
BRM84_RS05350	COG0582	viral genome integration into host DNA
BRM84_RS05360	COG0859	PFAM glycosyl transferase family 9
BRM84_RS05365	COG3642	lipopolysaccharide core region biosynthetic process
BRM84_RS05370	COG1234	tRNA 3'-trailer cleavage
BRM84_RS05375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRM84_RS05385	COG0315	cyclic pyranopterin monophosphate synthase activity
BRM84_RS05390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRM84_RS05395	COG0314	molybdopterin synthase activity
BRM84_RS05425	COG0537	adenosine 5'-monophosphoramidase activity
BRM84_RS05445	COG0714	Associated with various cellular activities
BRM84_RS05465	COG0242	peptide deformylase activity
BRM84_RS05515	COG3039	Transposase
BRM84_RS05545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM84_RS05550	COG0726	polysaccharide deacetylase
BRM84_RS05600	COG2211	Major facilitator Superfamily
BRM84_RS05610	COG1609	Transcriptional regulator
BRM84_RS05615	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS05620	COG2851	Citrate transporter
BRM84_RS05640	COG0642	Histidine kinase
BRM84_RS05650	COG2197	response regulator
BRM84_RS05670	COG0583	DNA-binding transcription factor activity
BRM84_RS05685	COG4191	Histidine kinase
BRM84_RS05705	COG0281	malic enzyme
BRM84_RS05705	COG0280	phosphate acetyltransferase
BRM84_RS05740	COG0352	thiamine-phosphate diphosphorylase activity
BRM84_RS05745	COG1773	rubredoxin
BRM84_RS05750	COG2912	Transglutaminase-like superfamily
BRM84_RS05770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRM84_RS05795	COG0006	proline dipeptidase activity
BRM84_RS05830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRM84_RS05845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRM84_RS05850	COG1561	YicC-like family, N-terminal region
BRM84_RS05875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM84_RS05885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRM84_RS05910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRM84_RS05960	COG0714	Associated with various cellular activities
BRM84_RS05980	COG2304	oxidoreductase activity
BRM84_RS06000	COG1301	dicarboxylic acid transport
BRM84_RS06005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRM84_RS06015	COG0739	heme binding
BRM84_RS06020	COG1376	ErfK ybiS ycfS ynhG family protein
BRM84_RS06045	COG1022	Amp-dependent synthetase and ligase
BRM84_RS06055	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS06070	COG0642	Histidine kinase
BRM84_RS06090	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRM84_RS06095	COG4149	molybdate abc transporter
BRM84_RS06100	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRM84_RS06105	COG3453	Protein conserved in bacteria
BRM84_RS06105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM84_RS06140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRM84_RS06160	COG2205	protein histidine kinase activity
BRM84_RS06165	COG0745	RESPONSE REGULATOR receiver
BRM84_RS06215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM84_RS06220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRM84_RS06365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRM84_RS06380	COG1842	Phage shock protein A
BRM84_RS06405	COG0754	glutathionylspermidine amidase activity
BRM84_RS06475	COG0531	amino acid
BRM84_RS06480	COG2197	response regulator
BRM84_RS06495	COG1113	amino acid transport
BRM84_RS06515	COG1271	oxidase subunit
BRM84_RS06520	COG1294	oxidase, subunit
BRM84_RS06530	COG2239	Acts as a magnesium transporter
BRM84_RS06540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM84_RS06545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM84_RS06555	COG1660	Displays ATPase and GTPase activities
BRM84_RS06560	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRM84_RS06565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM84_RS06580	COG1137	ATPase activity
BRM84_RS06585	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRM84_RS06595	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRM84_RS06605	COG0271	Belongs to the BolA IbaG family
BRM84_RS06615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRM84_RS06635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRM84_RS06650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRM84_RS06660	COG0628	permease
BRM84_RS06670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRM84_RS06675	COG3178	'Phosphotransferase
BRM84_RS06690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM84_RS06695	COG1555	photosystem II stabilization
BRM84_RS06740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM84_RS06750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRM84_RS06775	COG0228	four-way junction DNA binding
BRM84_RS06780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRM84_RS06785	COG0336	Belongs to the RNA methyltransferase TrmD family
BRM84_RS06800	COG0534	Mate efflux family protein
BRM84_RS06840	COG0542	response to heat
BRM84_RS06880	COG4206	TonB-dependent receptor
BRM84_RS06940	COG0019	diaminopimelate decarboxylase activity
BRM84_RS06950	COG2814	Major facilitator Superfamily
BRM84_RS06955	COG4264	IucA IucC family
BRM84_RS06965	COG4772	TonB-dependent receptor
BRM84_RS06980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRM84_RS06980	COG4651	solute:proton antiporter activity
BRM84_RS07015	COG0488	(ABC) transporter
BRM84_RS07040	COG0657	acetylesterase activity
BRM84_RS07040	COG2755	lipolytic protein G-D-S-L family
BRM84_RS07060	COG2207	Transcriptional regulator
BRM84_RS07095	COG3328	transposase activity
BRM84_RS07100	COG0174	glutamine synthetase
BRM84_RS07105	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRM84_RS07115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRM84_RS07130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM84_RS07160	COG2146	nitrite reductase [NAD(P)H] activity
BRM84_RS07175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRM84_RS07180	COG0719	Fe-S assembly protein
BRM84_RS07185	COG0396	ATPase activity
BRM84_RS07190	COG0719	Fe-S assembly protein
BRM84_RS07195	COG1959	2 iron, 2 sulfur cluster binding
BRM84_RS07215	COG0693	protein deglycase activity
BRM84_RS07260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRM84_RS07295	COG0519	Catalyzes the synthesis of GMP from XMP
BRM84_RS07305	COG1678	Uncharacterized ACR, COG1678
BRM84_RS07310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRM84_RS07325	COG1764	response to oxidative stress
BRM84_RS07335	COG0384	phenazine biosynthesis protein PhzF
BRM84_RS07345	COG0527	aspartate kinase activity
BRM84_RS07375	COG0142	geranyltranstransferase activity
BRM84_RS07380	COG0629	single-stranded DNA binding
BRM84_RS07385	COG3706	GGDEF domain
BRM84_RS07385	COG2203	Gaf domain
BRM84_RS07385	COG4251	negative regulation of phosphorylation
BRM84_RS07385	COG5001	Diguanylate cyclase
BRM84_RS07420	COG2879	small protein
BRM84_RS07425	COG1966	Carbon starvation protein
BRM84_RS07430	COG1741	Belongs to the pirin family
BRM84_RS07545	COG1741	Belongs to the pirin family
BRM84_RS07555	COG1515	deoxyribonuclease V activity
BRM84_RS07575	COG3590	peptidase
BRM84_RS07590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRM84_RS07595	COG2202	Pas domain
BRM84_RS07595	COG2200	EAL domain
BRM84_RS07595	COG2199	diguanylate cyclase activity
BRM84_RS07600	COG0835	chemotaxis
BRM84_RS07605	COG0840	transmembrane signaling receptor activity
BRM84_RS07610	COG2198	Histidine kinase
BRM84_RS07610	COG0643	Histidine kinase
BRM84_RS07620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRM84_RS07630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRM84_RS07650	COG2205	protein histidine kinase activity
BRM84_RS07675	COG3039	Transposase
BRM84_RS07700	COG3039	Transposase
BRM84_RS07735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRM84_RS07740	COG0735	belongs to the Fur family
BRM84_RS07805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRM84_RS07810	COG0084	hydrolase, TatD family'
BRM84_RS07825	COG1960	acyl-CoA dehydrogenase activity
BRM84_RS07840	COG0367	asparagine synthase
BRM84_RS07850	COG0305	Participates in initiation and elongation during chromosome replication
BRM84_RS07855	COG0415	Belongs to the DNA photolyase family
BRM84_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS07920	COG3039	Transposase
BRM84_RS07980	COG5001	Diguanylate cyclase
BRM84_RS07980	COG5002	protein histidine kinase activity
BRM84_RS07985	COG1187	pseudouridine synthase activity
BRM84_RS08010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM84_RS08020	COG0475	glutathione-regulated potassium exporter activity
BRM84_RS08025	COG5000	phosphorelay sensor kinase activity
BRM84_RS08025	COG5002	protein histidine kinase activity
BRM84_RS08030	COG0745	RESPONSE REGULATOR receiver
BRM84_RS08060	COG1132	(ABC) transporter
BRM84_RS08085	COG3039	Transposase
BRM84_RS08100	COG3039	Transposase
BRM84_RS08145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRM84_RS08155	COG4969	Belongs to the N-Me-Phe pilin family
BRM84_RS08160	COG2194	sulfuric ester hydrolase activity
BRM84_RS08200	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM84_RS08205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRM84_RS08220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRM84_RS08220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM84_RS08225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM84_RS08230	COG0564	pseudouridine synthase activity
BRM84_RS08255	COG3387	PFAM Glycoside hydrolase 15-related
BRM84_RS08260	COG1877	trehalose-phosphatase activity
BRM84_RS08300	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BRM84_RS08320	COG1595	DNA-templated transcription, initiation
BRM84_RS08330	COG1946	Acyl-CoA thioesterase
BRM84_RS08345	COG0824	Thioesterase
BRM84_RS08350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRM84_RS08360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRM84_RS08365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRM84_RS08370	COG0268	Binds directly to 16S ribosomal RNA
BRM84_RS08375	COG0728	peptidoglycan biosynthetic process
BRM84_RS08380	COG0196	riboflavin kinase activity
BRM84_RS08390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRM84_RS08395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRM84_RS08410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRM84_RS08415	COG1845	cytochrome c oxidase, subunit III
BRM84_RS08420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRM84_RS08440	COG3209	COG3209 Rhs family protein
BRM84_RS08440	COG3209	COG3209 Rhs family protein
BRM84_RS08560	COG0632	four-way junction helicase activity
BRM84_RS08570	COG2255	four-way junction helicase activity
BRM84_RS08575	COG0824	Thioesterase
BRM84_RS08585	COG0848	biopolymer transport protein
BRM84_RS08600	COG2885	chlorophyll binding
BRM84_RS08610	COG0602	queuosine metabolic process
BRM84_RS08620	COG1187	pseudouridine synthase activity
BRM84_RS08680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRM84_RS08705	COG0514	ATP-dependent DNA helicase (RecQ)
BRM84_RS08715	COG0783	Belongs to the Dps family
BRM84_RS08720	COG1643	Atp-dependent helicase
BRM84_RS08775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM84_RS08785	COG1215	transferase activity, transferring glycosyl groups
BRM84_RS08790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRM84_RS08800	COG1199	ATP-dependent helicase activity
BRM84_RS08810	COG1397	ADP-ribosylglycohydrolase
BRM84_RS08820	COG0189	ligase activity
BRM84_RS08835	COG0835	chemotaxis
BRM84_RS08840	COG0840	transmembrane signaling receptor activity
BRM84_RS08845	COG2198	Histidine kinase
BRM84_RS08845	COG0784	Response regulator, receiver
BRM84_RS08845	COG0643	Histidine kinase
BRM84_RS08890	COG1446	asparaginase
BRM84_RS08895	COG3142	Participates in the control of copper homeostasis
BRM84_RS08955	COG3537	Alpha-1,2-mannosidase
BRM84_RS09005	COG3039	Transposase
BRM84_RS09035	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM84_RS09055	COG1388	LysM domain
BRM84_RS09055	COG3858	chitin binding
BRM84_RS09070	COG0837	glucose binding
BRM84_RS09075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRM84_RS09085	COG0494	nUDIX hydrolase
BRM84_RS09095	COG3956	TIGRFAM MazG family protein
BRM84_RS09110	COG0330	HflC and HflK could
BRM84_RS09125	COG0509	glycine decarboxylation via glycine cleavage system
BRM84_RS09160	COG1960	acyl-CoA dehydrogenase activity
BRM84_RS09170	COG1309	transcriptional regulator
BRM84_RS09175	COG4771	TonB-dependent receptor
BRM84_RS09185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRM84_RS09195	COG0463	Glycosyl transferase, family 2
BRM84_RS09215	COG1272	protein, Hemolysin III
BRM84_RS09225	COG0739	heme binding
BRM84_RS09230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM84_RS09235	COG0626	cystathionine gamma-synthase activity
BRM84_RS09245	COG1760	l-serine dehydratase
BRM84_RS09260	COG2353	YceI-like domain
BRM84_RS09270	COG2353	YceI-like domain
BRM84_RS09320	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BRM84_RS09340	COG1960	acyl-CoA dehydrogenase activity
BRM84_RS09345	COG1024	Enoyl-CoA hydratase
BRM84_RS09365	COG1024	Enoyl-CoA hydratase
BRM84_RS09365	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM84_RS09380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM84_RS09410	COG1381	Involved in DNA repair and RecF pathway recombination
BRM84_RS09425	COG2954	triphosphatase activity
BRM84_RS09440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRM84_RS09445	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRM84_RS09450	COG3046	protein related to deoxyribodipyrimidine photolyase
BRM84_RS09460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BRM84_RS09465	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRM84_RS09470	COG1278	Cold shock
BRM84_RS09490	COG1201	RNA secondary structure unwinding
BRM84_RS09495	COG1793	dna ligase
BRM84_RS09505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRM84_RS09505	COG1793	dna ligase
BRM84_RS09535	COG0183	Belongs to the thiolase family
BRM84_RS09560	COG1451	nucleotide metabolic process
BRM84_RS09575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRM84_RS09620	COG1047	Peptidyl-prolyl cis-trans
BRM84_RS09635	COG2824	Alkylphosphonate utilization operon protein PhnA
BRM84_RS09650	COG1902	pentaerythritol trinitrate reductase activity
BRM84_RS09655	COG2814	Major facilitator Superfamily
BRM84_RS09710	COG0392	lysyltransferase activity
BRM84_RS09710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRM84_RS09720	COG0251	oxidation-reduction process
BRM84_RS09725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM84_RS09740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM84_RS09765	COG1595	DNA-templated transcription, initiation
BRM84_RS09785	COG2878	Part of a membrane complex involved in electron transport
BRM84_RS09795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM84_RS09795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM84_RS09815	COG0833	amino acid
BRM84_RS09820	COG2040	homocysteine
BRM84_RS09835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM84_RS09870	COG2895	sulfate adenylyltransferase (ATP) activity
BRM84_RS09870	COG0529	Catalyzes the synthesis of activated sulfate
BRM84_RS09915	COG1981	membrane
BRM84_RS09940	COG1131	(ABC) transporter
BRM84_RS09945	COG4771	TonB-dependent receptor
BRM84_RS09955	COG0825	malonyl-CoA metabolic process
BRM84_RS09975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM84_RS09980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM84_RS10000	COG0750	zinc metalloprotease
BRM84_RS10010	COG0575	Belongs to the CDS family
BRM84_RS10020	COG0233	cytoplasmic translational termination
BRM84_RS10035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRM84_RS10095	COG1393	Belongs to the ArsC family
BRM84_RS10110	COG0367	asparagine synthase
BRM84_RS10125	COG4774	siderophore transport
BRM84_RS10165	COG1566	PFAM secretion protein HlyD family protein
BRM84_RS10170	COG2814	Major facilitator Superfamily
BRM84_RS10215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRM84_RS10225	COG1960	acyl-CoA dehydrogenase activity
BRM84_RS10250	COG2914	Belongs to the UPF0125 (RnfH) family
BRM84_RS10260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM84_RS10270	COG0497	DNA recombination
BRM84_RS10280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRM84_RS10285	COG0443	Heat shock 70 kDa protein
BRM84_RS10290	COG0484	heat shock protein binding
BRM84_RS10300	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRM84_RS10305	COG1605	Chorismate mutase
BRM84_RS10305	COG0287	Prephenate dehydrogenase
BRM84_RS10325	COG0583	DNA-binding transcription factor activity
BRM84_RS10340	COG1132	(ABC) transporter
BRM84_RS10375	COG2850	peptidyl-arginine hydroxylation
BRM84_RS10455	COG1131	(ABC) transporter
BRM84_RS10460	COG1725	Transcriptional regulator
BRM84_RS10470	COG0386	Belongs to the glutathione peroxidase family
BRM84_RS10485	COG2900	Belongs to the SlyX family
BRM84_RS10500	COG1609	Transcriptional regulator
BRM84_RS10510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM84_RS10520	COG0646	methionine synthase
BRM84_RS10520	COG1410	methionine synthase
BRM84_RS10525	COG0646	methionine synthase
BRM84_RS10525	COG1410	methionine synthase
BRM84_RS10530	COG2226	methyltransferase
BRM84_RS10535	COG1960	acyl-CoA dehydrogenase activity
BRM84_RS10565	COG0557	exoribonuclease II activity
BRM84_RS10585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM84_RS10600	COG3039	Transposase
BRM84_RS10625	COG3328	transposase activity
BRM84_RS10635	COG1278	Cold shock
BRM84_RS10650	COG3039	Transposase
BRM84_RS10655	COG3039	Transposase
BRM84_RS10705	COG3039	Transposase
BRM84_RS10715	COG0583	DNA-binding transcription factor activity
BRM84_RS10775	COG2201	protein-glutamate methylesterase activity
BRM84_RS10810	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BRM84_RS10820	COG0531	amino acid
BRM84_RS10825	COG0531	amino acid
BRM84_RS10835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRM84_RS10840	COG0277	FAD linked oxidase domain protein
BRM84_RS10905	COG0436	Aminotransferase
BRM84_RS10930	COG1187	pseudouridine synthase activity
BRM84_RS10935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRM84_RS10940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRM84_RS10945	COG2350	Protein conserved in bacteria
BRM84_RS10975	COG1175	transmembrane transport
BRM84_RS10980	COG0395	ABC-type sugar transport system, permease component
BRM84_RS11005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM84_RS11015	COG2957	Belongs to the agmatine deiminase family
BRM84_RS11030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRM84_RS11035	COG0539	negative regulation of cytoplasmic translation
BRM84_RS11040	COG0776	regulation of translation
BRM84_RS11050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRM84_RS11055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRM84_RS11065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRM84_RS11085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRM84_RS11100	COG3002	Belongs to the UPF0753 family
BRM84_RS11105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM84_RS11110	COG0583	DNA-binding transcription factor activity
BRM84_RS11140	COG0583	DNA-binding transcription factor activity
BRM84_RS11165	COG1914	H( )-stimulated, divalent metal cation uptake system
BRM84_RS11185	COG0668	transmembrane transport
BRM84_RS11225	COG3039	Transposase
BRM84_RS11245	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS11250	COG1183	phosphatidylcholine synthase activity
BRM84_RS11260	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRM84_RS11275	COG0723	plastoquinol--plastocyanin reductase activity
BRM84_RS11275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM84_RS11285	COG2183	response to ionizing radiation
BRM84_RS11300	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRM84_RS11315	COG0671	phosphoesterase, PA-phosphatase related
BRM84_RS11340	COG1794	racemase activity, acting on amino acids and derivatives
BRM84_RS11350	COG0697	spore germination
BRM84_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
BRM84_RS11410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRM84_RS11425	COG0124	histidyl-tRNA synthetase
BRM84_RS11445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRM84_RS11460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BRM84_RS11460	COG0131	Imidazoleglycerol-phosphate dehydratase
BRM84_RS11470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRM84_RS11480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRM84_RS11480	COG0140	phosphoribosyl-ATP diphosphatase activity
BRM84_RS11520	COG0653	protein targeting
BRM84_RS11525	COG3039	Transposase
BRM84_RS11745	COG2201	protein-glutamate methylesterase activity
BRM84_RS11755	COG2801	Transposase and inactivated derivatives
BRM84_RS11770	COG3039	Transposase
BRM84_RS11795	COG3328	transposase activity
BRM84_RS11830	COG0322	excinuclease ABC activity
BRM84_RS11840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRM84_RS11850	COG1663	tetraacyldisaccharide 4'-kinase activity
BRM84_RS11865	COG0811	peptide transport
BRM84_RS11895	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRM84_RS11910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRM84_RS11925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRM84_RS11940	COG0354	folic acid binding
BRM84_RS11955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM84_RS11965	COG0363	glucosamine-6-phosphate deaminase activity
BRM84_RS11970	COG0129	dihydroxy-acid dehydratase activity
BRM84_RS11975	COG0800	Aldolase
BRM84_RS12005	COG0784	Response regulator, receiver
BRM84_RS12005	COG2205	protein histidine kinase activity
BRM84_RS12005	COG5002	protein histidine kinase activity
BRM84_RS12085	COG0386	Belongs to the glutathione peroxidase family
BRM84_RS12175	COG5001	Diguanylate cyclase
BRM84_RS12175	COG2203	Gaf domain
BRM84_RS12175	COG4251	negative regulation of phosphorylation
BRM84_RS12175	COG3706	GGDEF domain
BRM84_RS12195	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM84_RS12245	COG0617	tRNA 3'-terminal CCA addition
BRM84_RS12255	COG1469	GTP cyclohydrolase I activity
BRM84_RS12260	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM84_RS12310	COG4566	intracellular signal transduction
BRM84_RS12350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRM84_RS12355	COG0077	Prephenate dehydratase
BRM84_RS12355	COG1605	Chorismate mutase
BRM84_RS12365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRM84_RS12410	COG1228	amidohydrolase
BRM84_RS12415	COG2986	histidine ammonia-lyase
BRM84_RS12425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRM84_RS12450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRM84_RS12465	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRM84_RS12480	COG3115	cell septum assembly
BRM84_RS12490	COG0359	binds to the 23S rRNA
BRM84_RS12500	COG0360	Binds together with S18 to 16S ribosomal RNA
BRM84_RS12505	COG0316	Belongs to the HesB IscA family
BRM84_RS12540	COG0288	reversible hydration of carbon dioxide
BRM84_RS12565	COG2925	Exonuclease
BRM84_RS12575	COG0667	Aldo Keto reductase
BRM84_RS12600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM84_RS12600	COG0116	Belongs to the methyltransferase superfamily
BRM84_RS12645	COG0494	nUDIX hydrolase
BRM84_RS12655	COG1024	Enoyl-CoA hydratase
BRM84_RS12665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRM84_RS12680	COG3039	Transposase
BRM84_RS12720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRM84_RS12725	COG0573	inorganic phosphate transmembrane transporter activity
BRM84_RS12740	COG0704	Plays a role in the regulation of phosphate uptake
BRM84_RS12750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM84_RS12765	COG3328	transposase activity
BRM84_RS12800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM84_RS12805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM84_RS12810	COG1862	Preprotein translocase
BRM84_RS12815	COG0343	queuine tRNA-ribosyltransferase activity
BRM84_RS12905	COG0405	Gamma-glutamyltransferase
BRM84_RS12910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRM84_RS12925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRM84_RS12930	COG0742	ribosomal rna small subunit methyltransferase
BRM84_RS12950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRM84_RS12980	COG3039	Transposase
BRM84_RS12990	COG3039	Transposase
BRM84_RS13020	COG0303	'Molybdopterin
BRM84_RS13030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM84_RS13040	COG1426	Protein conserved in bacteria
BRM84_RS13050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRM84_RS13065	COG1024	Enoyl-CoA hydratase
BRM84_RS13065	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM84_RS13070	COG0183	Belongs to the thiolase family
BRM84_RS13075	COG0038	chloride channel
BRM84_RS13095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRM84_RS13120	COG1674	ftsk spoiiie
BRM84_RS13125	COG0492	ferredoxin-NADP+ reductase activity
BRM84_RS13150	COG0542	response to heat
BRM84_RS13165	COG0482	sulfurtransferase activity
BRM84_RS13190	COG5001	Diguanylate cyclase
BRM84_RS13195	COG4585	Histidine kinase
BRM84_RS13205	COG5002	protein histidine kinase activity
BRM84_RS13225	COG0835	chemotaxis
BRM84_RS13225	COG0784	Response regulator, receiver
BRM84_RS13235	COG1558	bacterial-type flagellum-dependent cell motility
BRM84_RS13240	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRM84_RS13250	COG4787	bacterial-type flagellum-dependent cell motility
BRM84_RS13290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRM84_RS13295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRM84_RS13325	COG2201	protein-glutamate methylesterase activity
BRM84_RS13345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM84_RS13355	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS13390	COG1677	Flagellar hook-basal body complex protein FliE
BRM84_RS13440	COG3190	flagellar
BRM84_RS13460	COG1684	flagellar biosynthetic protein fliR
BRM84_RS13515	COG0643	Histidine kinase
BRM84_RS13515	COG0784	Response regulator, receiver
BRM84_RS13515	COG2198	Histidine kinase
BRM84_RS13555	COG3039	Transposase
BRM84_RS13650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRM84_RS13655	COG4988	ABC transporter
BRM84_RS13680	COG1271	oxidase subunit
BRM84_RS13715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRM84_RS13735	COG0165	Argininosuccinate lyase
BRM84_RS13750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRM84_RS13755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM84_RS13765	COG0137	argininosuccinate synthase activity
BRM84_RS13770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRM84_RS13785	COG2166	iron-sulfur cluster assembly
BRM84_RS13810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRM84_RS13850	COG3039	Transposase
BRM84_RS13865	COG4677	pectinesterase activity
BRM84_RS13895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRM84_RS13900	COG0402	S-adenosylhomocysteine deaminase activity
BRM84_RS13915	COG1509	lysine 2,3-aminomutase activity
BRM84_RS13920	COG5001	Diguanylate cyclase
BRM84_RS13920	COG3300	MHYT domain
BRM84_RS13935	COG0483	inositol monophosphate 1-phosphatase activity
BRM84_RS13940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM84_RS13965	COG0488	(ABC) transporter
BRM84_RS13970	COG0513	Belongs to the DEAD box helicase family
BRM84_RS13990	COG0625	glutathione transferase activity
BRM84_RS14000	COG1671	Belongs to the UPF0178 family
BRM84_RS14005	COG4681	YaeQ
BRM84_RS14010	COG2081	HI0933 family
BRM84_RS14030	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS14055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRM84_RS14060	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM84_RS14065	COG0802	atpase or kinase
BRM84_RS14070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRM84_RS14070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRM84_RS14075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM84_RS14100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM84_RS14185	COG3328	transposase activity
BRM84_RS14230	COG2969	positive regulation of protein catabolic process
BRM84_RS14235	COG0625	glutathione transferase activity
BRM84_RS14240	COG2857	Cytochrome c1
BRM84_RS14245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRM84_RS14250	COG0723	plastoquinol--plastocyanin reductase activity
BRM84_RS14260	COG0741	lytic transglycosylase activity
BRM84_RS14285	COG1702	phosphate starvation-inducible protein PhoH
BRM84_RS14305	COG4535	Mg2 and Co2 transporter CorC
BRM84_RS14320	COG1012	belongs to the aldehyde dehydrogenase family
BRM84_RS14330	COG1177	transmembrane transport
BRM84_RS14340	COG3842	ATPase activity
BRM84_RS14380	COG0174	glutamine synthetase
BRM84_RS14385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM84_RS14395	COG0477	Major facilitator Superfamily
BRM84_RS14405	COG0243	molybdopterin cofactor binding
BRM84_RS14415	COG2223	nitrite transmembrane transporter activity
BRM84_RS14435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRM84_RS14440	COG1121	(ABC) transporter
BRM84_RS14450	COG2733	membrane
BRM84_RS14455	COG0784	Response regulator, receiver
BRM84_RS14455	COG2205	protein histidine kinase activity
BRM84_RS14455	COG5002	protein histidine kinase activity
BRM84_RS14465	COG3039	Transposase
BRM84_RS14475	COG2902	Dehydrogenase
BRM84_RS14485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM84_RS14490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM84_RS14510	COG1609	Transcriptional regulator
BRM84_RS14515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM84_RS14515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM84_RS14520	COG1105	Belongs to the carbohydrate kinase PfkB family
BRM84_RS14525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM84_RS14525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM84_RS14540	COG3039	Transposase
BRM84_RS14660	COG3039	Transposase
BRM84_RS14690	COG4771	TonB-dependent receptor
BRM84_RS14700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM84_RS14720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRM84_RS14725	COG1360	Flagellar Motor Protein
BRM84_RS14735	COG0835	chemotaxis
BRM84_RS14745	COG0745	RESPONSE REGULATOR receiver
BRM84_RS14770	COG0840	transmembrane signaling receptor activity
BRM84_RS14785	COG0840	transmembrane signaling receptor activity
BRM84_RS14795	COG0840	transmembrane signaling receptor activity
BRM84_RS14805	COG0840	transmembrane signaling receptor activity
BRM84_RS14810	COG0840	transmembrane signaling receptor activity
BRM84_RS14815	COG0840	transmembrane signaling receptor activity
BRM84_RS14820	COG0840	transmembrane signaling receptor activity
BRM84_RS14840	COG0835	chemotaxis
BRM84_RS14865	COG0840	transmembrane signaling receptor activity
BRM84_RS14900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM84_RS14930	COG0318	PFAM AMP-dependent synthetase and ligase
BRM84_RS14935	COG1024	Enoyl-CoA hydratase
BRM84_RS14940	COG0784	Response regulator, receiver
BRM84_RS14940	COG2205	protein histidine kinase activity
BRM84_RS14940	COG2198	Histidine kinase
BRM84_RS15015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRM84_RS15025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM84_RS15030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRM84_RS15040	COG0505	Belongs to the CarA family
BRM84_RS15045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRM84_RS15055	COG2258	MOSC domain
BRM84_RS15060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRM84_RS15110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRM84_RS15130	COG0477	Major facilitator Superfamily
BRM84_RS15140	COG1070	Carbohydrate kinase
BRM84_RS15150	COG1501	Belongs to the glycosyl hydrolase 31 family
BRM84_RS15165	COG0800	Aldolase
BRM84_RS15170	COG4948	Mandelate Racemase Muconate Lactonizing
BRM84_RS15180	COG3734	2-keto-3-deoxy-galactonokinase
BRM84_RS15185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRM84_RS15195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM84_RS15210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRM84_RS15215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRM84_RS15225	COG0351	phosphomethylpyrimidine kinase
BRM84_RS15255	COG0583	DNA-binding transcription factor activity
BRM84_RS15260	COG1741	Belongs to the pirin family
BRM84_RS15280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRM84_RS15285	COG0305	Participates in initiation and elongation during chromosome replication
BRM84_RS15310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRM84_RS15315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRM84_RS15320	COG2137	regulation of response to DNA damage stimulus
BRM84_RS15330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRM84_RS15345	COG1546	Belongs to the CinA family
BRM84_RS15350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRM84_RS15365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRM84_RS15375	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRM84_RS15380	COG1534	Rna-binding protein
BRM84_RS15395	COG1238	metal cluster binding
BRM84_RS15400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM84_RS15405	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRM84_RS15410	COG2840	Smr protein MutS2
BRM84_RS15425	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRM84_RS15440	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRM84_RS15445	COG0148	phosphopyruvate hydratase activity
BRM84_RS15455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRM84_RS15460	COG0504	CTP synthase activity
BRM84_RS15485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BRM84_RS15490	COG0306	phosphate transporter
BRM84_RS15505	COG1253	flavin adenine dinucleotide binding
BRM84_RS15520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRM84_RS15540	COG0477	Major facilitator Superfamily
BRM84_RS15550	COG1132	(ABC) transporter
BRM84_RS15555	COG1136	(ABC) transporter
BRM84_RS15575	COG0438	transferase activity, transferring glycosyl groups
BRM84_RS15585	COG2264	protein methyltransferase activity
BRM84_RS15615	COG2244	polysaccharide biosynthetic process
BRM84_RS15665	COG1595	DNA-templated transcription, initiation
BRM84_RS15680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM84_RS15700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM84_RS15755	COG2201	protein-glutamate methylesterase activity
BRM84_RS15775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM84_RS15780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM84_RS15835	COG1858	cytochrome C peroxidase
BRM84_RS15865	COG0515	serine threonine protein kinase
BRM84_RS15870	COG0631	protein serine/threonine phosphatase activity
BRM84_RS15985	COG3039	Transposase
BRM84_RS16005	COG3039	Transposase
BRM84_RS16050	COG0316	Belongs to the HesB IscA family
BRM84_RS16050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRM84_RS16055	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRM84_RS16065	COG0428	transporter
BRM84_RS16070	COG0428	transporter
BRM84_RS16075	COG3064	Membrane
BRM84_RS16085	COG1530	ribonuclease E activity
BRM84_RS16105	COG1054	Belongs to the UPF0176 family
BRM84_RS16110	COG3039	Transposase
BRM84_RS16130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRM84_RS16170	COG3039	Transposase
BRM84_RS16175	COG3039	Transposase
BRM84_RS16205	COG1648	precorrin-2 dehydrogenase activity
BRM84_RS16205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRM84_RS16230	COG0746	molybdenum cofactor guanylyltransferase activity
BRM84_RS16330	COG4206	TonB-dependent receptor
BRM84_RS16380	COG0531	amino acid
BRM84_RS16395	COG0006	proline dipeptidase activity
BRM84_RS16405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM84_RS16420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM84_RS16425	COG3938	Belongs to the proline racemase family
BRM84_RS16435	COG0552	protein localization to endoplasmic reticulum
BRM84_RS16460	COG4191	Histidine kinase
BRM84_RS16460	COG0784	Response regulator, receiver
BRM84_RS16550	COG3040	lipid binding
BRM84_RS16590	COG0438	transferase activity, transferring glycosyl groups
BRM84_RS16600	COG0438	transferase activity, transferring glycosyl groups
BRM84_RS16605	COG0438	transferase activity, transferring glycosyl groups
BRM84_RS16675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRM84_RS16710	COG4969	Belongs to the N-Me-Phe pilin family
BRM84_RS16750	COG1611	Belongs to the LOG family
BRM84_RS16765	COG2095	MarC family integral membrane protein
BRM84_RS16775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM84_RS16810	COG1185	polyribonucleotide nucleotidyltransferase activity
BRM84_RS16815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRM84_RS16835	COG0195	Participates in both transcription termination and antitermination
BRM84_RS16840	COG0779	Required for maturation of 30S ribosomal subunits
BRM84_RS16850	COG1007	ATP synthesis coupled electron transport
BRM84_RS16885	COG1034	ATP synthesis coupled electron transport
BRM84_RS16890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRM84_RS16895	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRM84_RS16900	COG0649	NAD binding
BRM84_RS16905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM84_RS16915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM84_RS16930	COG0149	triose-phosphate isomerase activity
BRM84_RS16980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM84_RS16985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRM84_RS17010	COG0135	phosphoribosylanthranilate isomerase activity
BRM84_RS17015	COG0101	tRNA pseudouridine synthase activity
BRM84_RS17035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRM84_RS17040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRM84_RS17045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRM84_RS17050	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM84_RS17105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM84_RS17115	COG0412	Dienelactone hydrolase
BRM84_RS17135	COG0717	Belongs to the dCTP deaminase family
BRM84_RS17140	COG0489	protein tyrosine kinase activity
BRM84_RS17185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM84_RS17190	COG2311	Membrane
BRM84_RS17195	COG1047	Peptidyl-prolyl cis-trans
BRM84_RS17200	COG0791	NLP P60 protein
BRM84_RS17205	COG0791	NLP P60 protein
BRM84_RS17220	COG1301	dicarboxylic acid transport
BRM84_RS17225	COG1785	Belongs to the alkaline phosphatase family
BRM84_RS17230	COG0037	tRNA processing
BRM84_RS17235	COG1722	exodeoxyribonuclease VII activity
BRM84_RS17240	COG0142	geranyltranstransferase activity
BRM84_RS17265	COG0312	modulator of DNA gyrase
BRM84_RS17270	COG3028	Belongs to the UPF0307 family
BRM84_RS17275	COG0312	modulator of DNA gyrase
BRM84_RS17285	COG3164	Protein of unknown function
BRM84_RS17300	COG2968	Membrane
BRM84_RS17325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRM84_RS17350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRM84_RS17380	COG3118	belongs to the thioredoxin family
BRM84_RS17460	COG3039	Transposase
BRM84_RS17465	COG3039	Transposase
BRM84_RS17560	COG2022	thiamine diphosphate biosynthetic process
BRM84_RS17575	COG3273	potassium ion transport
BRM84_RS17575	COG0471	metal ion transport
BRM84_RS17605	COG1970	mechanosensitive ion channel activity
BRM84_RS17630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM84_RS17660	COG0308	aminopeptidase N
BRM84_RS17665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM84_RS17680	COG0529	Catalyzes the synthesis of activated sulfate
BRM84_RS17680	COG2895	sulfate adenylyltransferase (ATP) activity
BRM84_RS17685	COG0175	sulfate reduction
BRM84_RS17690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM84_RS17695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRM84_RS17700	COG0175	sulfate reduction
BRM84_RS17720	COG2205	protein histidine kinase activity
BRM84_RS17720	COG2198	Histidine kinase
BRM84_RS17720	COG0784	Response regulator, receiver
BRM84_RS17765	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRM84_RS17770	COG3588	fructose-bisphosphate aldolase
BRM84_RS17775	COG0469	pyruvate kinase activity
BRM84_RS17820	COG0753	catalase activity
BRM84_RS17845	COG3039	Transposase
BRM84_RS17865	COG2207	Transcriptional regulator
BRM84_RS17865	COG1917	Cupin 2, conserved barrel domain protein
BRM84_RS17895	COG1506	peptidase
BRM84_RS17895	COG0823	Involved in the tonB-independent uptake of proteins
BRM84_RS17920	COG3039	Transposase
BRM84_RS17925	COG1297	OPT oligopeptide transporter protein
BRM84_RS18030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRM84_RS18035	COG3039	Transposase
BRM84_RS18060	COG3039	Transposase
BRM84_RS18065	COG0732	type I restriction modification DNA specificity domain
BRM84_RS18070	COG3039	Transposase
BRM84_RS18080	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRM84_RS18085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRM84_RS18105	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRM84_RS18305	COG3179	chitinase
BRM84_RS18360	COG3039	Transposase
BRM84_RS18495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRM84_RS18510	COG2197	response regulator
BRM84_RS18515	COG4585	Histidine kinase
BRM84_RS18535	COG2894	cell division
BRM84_RS18540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRM84_RS18550	COG0642	Histidine kinase
BRM84_RS18555	COG0745	RESPONSE REGULATOR receiver
BRM84_RS18560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRM84_RS18570	COG2194	sulfuric ester hydrolase activity
BRM84_RS18600	COG3551	Protein conserved in bacteria
BRM84_RS18665	COG0203	ribosomal protein L17
BRM84_RS18675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRM84_RS18680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRM84_RS18690	COG0201	protein transport
BRM84_RS18700	COG1841	ribosomal large subunit assembly
BRM84_RS18730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRM84_RS18740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRM84_RS18745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRM84_RS18750	COG0255	Belongs to the universal ribosomal protein uL29 family
BRM84_RS18755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRM84_RS18765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRM84_RS18780	COG0089	rRNA binding
BRM84_RS18785	COG0088	Forms part of the polypeptide exit tunnel
BRM84_RS18790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRM84_RS18795	COG0051	transcription antitermination factor activity, RNA binding
BRM84_RS18820	COG0049	tRNA binding
BRM84_RS18825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRM84_RS18830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRM84_RS18835	COG0085	RNA polymerase activity
BRM84_RS18840	COG0222	ribosome binding
BRM84_RS18845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRM84_RS18855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRM84_RS18865	COG0250	Participates in transcription elongation, termination and antitermination
BRM84_RS18870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRM84_RS18900	COG0012	GTP binding
BRM84_RS18905	COG0193	aminoacyl-tRNA hydrolase activity
BRM84_RS18915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRM84_RS18930	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BRM84_RS18945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRM84_RS18955	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRM84_RS18975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM84_RS18980	COG1295	ribonuclease BN
BRM84_RS19010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRM84_RS19020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRM84_RS19050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRM84_RS19075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRM84_RS19090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM84_RS19090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM84_RS19140	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM84_RS19150	COG3634	alkyl hydroperoxide reductase activity
BRM84_RS19155	COG0583	DNA-binding transcription factor activity
BRM84_RS19165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM84_RS19245	COG4783	chaperone-mediated protein folding
BRM84_RS19260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRM84_RS19270	COG0438	transferase activity, transferring glycosyl groups
BRM84_RS19275	COG0671	phosphoesterase, PA-phosphatase related
BRM84_RS19280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM84_RS19300	COG2833	Protein of unknown function (DUF455)
BRM84_RS19320	COG0285	dihydrofolate synthase activity
BRM84_RS19330	COG0406	alpha-ribazole phosphatase activity
BRM84_RS19365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRM84_RS19370	COG4208	sulfate ABC transporter
BRM84_RS19375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRM84_RS19380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRM84_RS19385	COG0156	8-amino-7-oxononanoate synthase activity
BRM84_RS19415	COG0604	alcohol dehydrogenase
BRM84_RS19420	COG1902	pentaerythritol trinitrate reductase activity
BRM84_RS19420	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRM84_RS19560	COG3386	PFAM SMP-30 Gluconolaconase
BRM84_RS19580	COG1024	Enoyl-CoA hydratase
BRM84_RS19590	COG0318	PFAM AMP-dependent synthetase and ligase
BRM84_RS19595	COG0583	DNA-binding transcription factor activity
BRM84_RS19635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM84_RS19640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM84_RS19650	COG2096	Adenosyltransferase
BRM84_RS19655	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRM84_RS19670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRM84_RS19680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRM84_RS19685	COG2967	ApaG domain
BRM84_RS19710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRM84_RS19730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRM84_RS19755	COG0642	Histidine kinase
BRM84_RS19770	COG4181	ATPase activity
BRM84_RS19780	COG2175	clavaminate synthase activity
BRM84_RS19830	COG0667	Aldo Keto reductase
BRM84_RS19840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRM84_RS19845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM84_RS19865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM84_RS19880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRM84_RS19935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRM84_RS19940	COG2226	methyltransferase
BRM84_RS19995	COG3321	synthase
BRM84_RS19995	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS19995	COG0604	alcohol dehydrogenase
BRM84_RS20010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRM84_RS20025	COG0494	nUDIX hydrolase
BRM84_RS20040	COG1388	LysM domain
BRM84_RS20040	COG4942	peptidase
BRM84_RS20050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRM84_RS20065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRM84_RS20070	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRM84_RS20075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM84_RS20090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRM84_RS20095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRM84_RS20110	COG3116	cell division
BRM84_RS20115	COG0275	rRNA processing
BRM84_RS20150	COG0792	nuclease activity
BRM84_RS20155	COG1988	membrane-bound metal-dependent
BRM84_RS20160	COG0277	FAD linked oxidase domain protein
BRM84_RS20165	COG0745	RESPONSE REGULATOR receiver
BRM84_RS20170	COG2205	protein histidine kinase activity
BRM84_RS20180	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRM84_RS20185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRM84_RS20210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRM84_RS20215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM84_RS20220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRM84_RS20240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM84_RS20240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM84_RS20260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRM84_RS20280	COG0488	(ABC) transporter
BRM84_RS20330	COG2205	protein histidine kinase activity
BRM84_RS20370	COG2205	protein histidine kinase activity
BRM84_RS20390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRM84_RS20425	COG3039	Transposase
BRM84_RS20430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM84_RS20445	COG3039	Transposase
BRM84_RS20500	COG3039	Transposase
BRM84_RS20550	COG1649	PFAM Uncharacterised BCR, COG1649
BRM84_RS20550	COG0726	polysaccharide deacetylase
BRM84_RS20555	COG1215	transferase activity, transferring glycosyl groups
BRM84_RS20565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRM84_RS20570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM84_RS20575	COG1609	Transcriptional regulator
BRM84_RS20585	COG2188	Transcriptional regulator
BRM84_RS20600	COG3250	beta-galactosidase activity
BRM84_RS20655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRM84_RS20660	COG4191	Histidine kinase
BRM84_RS20665	COG0784	Response regulator, receiver
BRM84_RS20670	COG4251	negative regulation of phosphorylation
BRM84_RS20675	COG2823	Periplasmic or secreted lipoprotein
BRM84_RS20680	COG0673	inositol 2-dehydrogenase activity
BRM84_RS20685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRM84_RS20720	COG1051	belongs to the nudix hydrolase family
BRM84_RS20720	COG1056	cytidyltransferase-related domain
BRM84_RS20755	COG2921	Belongs to the UPF0250 family
BRM84_RS20770	COG1686	Belongs to the peptidase S11 family
BRM84_RS20780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRM84_RS20785	COG2951	lytic endotransglycosylase activity
BRM84_RS20800	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRM84_RS20800	COG1388	LysM domain
BRM84_RS20800	COG3409	Peptidoglycan-binding domain 1 protein
BRM84_RS20845	COG0772	Belongs to the SEDS family
BRM84_RS20860	COG1792	Involved in formation and maintenance of cell shape
BRM84_RS20865	COG1077	Cell shape determining protein MreB Mrl
BRM84_RS20870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM84_RS20915	COG2199	diguanylate cyclase activity
BRM84_RS20920	COG0308	aminopeptidase N
BRM84_RS20950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRM84_RS20980	COG0436	Aminotransferase
BRM84_RS20995	COG1505	serine-type exopeptidase activity
BRM84_RS21020	COG0181	hydroxymethylbilane synthase activity
BRM84_RS21030	COG3275	phosphorelay sensor kinase activity
BRM84_RS21075	COG0659	secondary active sulfate transmembrane transporter activity
BRM84_RS21080	COG5297	Belongs to the glycosyl hydrolase family 6
BRM84_RS21080	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM84_RS21155	COG0598	Magnesium transport protein CorA
BRM84_RS21165	COG1113	amino acid transport
BRM84_RS21175	COG5297	Belongs to the glycosyl hydrolase family 6
BRM84_RS21180	COG4305	rare lipoprotein A
BRM84_RS21185	COG0697	spore germination
BRM84_RS21245	COG4221	oxidoreductase activity
BRM84_RS21275	COG0456	acetyltransferase
BRM84_RS21285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRM84_RS21340	COG2111	Na H antiporter
BRM84_RS21340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM84_RS21345	COG1006	Multisubunit Na H antiporter MnhC subunit
BRM84_RS21350	COG0651	ATP synthesis coupled electron transport
BRM84_RS21360	COG2212	antiporter activity
BRM84_RS21365	COG1320	monovalent cation:proton antiporter activity
BRM84_RS21375	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BRM84_RS21395	COG3104	oligopeptide transport
BRM84_RS21400	COG3483	tryptophan 2,3-dioxygenase activity
BRM84_RS21410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRM84_RS21445	COG0183	Belongs to the thiolase family
BRM84_RS21500	COG3039	Transposase
BRM84_RS21530	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRM84_RS21535	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRM84_RS21545	COG4948	Mandelate Racemase Muconate Lactonizing
BRM84_RS21585	COG0531	amino acid
BRM84_RS21620	COG4682	membrane
BRM84_RS21625	COG2133	pyrroloquinoline quinone binding
BRM84_RS21665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRM84_RS21670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRM84_RS21680	COG1610	YqeY-like protein
BRM84_RS21695	COG1295	ribonuclease BN
BRM84_RS21700	COG0358	DNA primase activity
BRM84_RS21765	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRM84_RS21780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRM84_RS21830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRM84_RS21835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRM84_RS21840	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BRM84_RS21850	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BRM84_RS21855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM84_RS21870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRM84_RS21950	COG3039	Transposase
BRM84_RS21965	COG3328	transposase activity
BRM84_RS21980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM84_RS21980	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM84_RS21990	COG1473	amidohydrolase
BRM84_RS21995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM84_RS22000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM84_RS22015	COG5383	Protein conserved in bacteria
BRM84_RS22055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRM84_RS22060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRM84_RS22075	COG0028	Belongs to the TPP enzyme family
BRM84_RS22080	COG4191	Histidine kinase
BRM84_RS22105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRM84_RS22120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM84_RS22125	COG3177	Filamentation induced by cAMP protein fic
BRM84_RS22140	COG0596	Alpha beta hydrolase
BRM84_RS22145	COG0727	PFAM Uncharacterised protein family (UPF0153)
BRM84_RS22150	COG0318	PFAM AMP-dependent synthetase and ligase
BRM84_RS22155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRM84_RS22215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRM84_RS22225	COG0129	dihydroxy-acid dehydratase activity
BRM84_RS22250	COG3039	Transposase
BRM84_RS22260	COG0408	coproporphyrinogen oxidase activity
BRM84_RS22360	COG2353	YceI-like domain
BRM84_RS22390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM84_RS22405	COG3386	PFAM SMP-30 Gluconolaconase
BRM84_RS22445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRM84_RS22460	COG4771	TonB-dependent receptor
BRM84_RS22470	COG0459	protein refolding
BRM84_RS22495	COG1252	NADH dehydrogenase
BRM84_RS22505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM84_RS22510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRM84_RS22515	COG3437	response regulator, receiver
BRM84_RS22520	COG2177	Part of the ABC transporter FtsEX involved in
BRM84_RS22525	COG2884	Cell division ATP-binding protein ftsE
BRM84_RS22535	COG3118	belongs to the thioredoxin family
BRM84_RS22540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRM84_RS22555	COG0729	surface antigen
BRM84_RS22560	COG2911	Protein conserved in bacteria
BRM84_RS22595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM84_RS22610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM84_RS22670	COG1733	regulation of RNA biosynthetic process
BRM84_RS22675	COG0702	epimerase
BRM84_RS22710	COG0583	DNA-binding transcription factor activity
BRM84_RS22715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM84_RS22735	COG0745	RESPONSE REGULATOR receiver
BRM84_RS22765	COG1902	pentaerythritol trinitrate reductase activity
BRM84_RS22770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRM84_RS22780	COG2814	Major facilitator Superfamily
BRM84_RS22785	COG0583	DNA-binding transcription factor activity
BRM84_RS22805	COG0084	hydrolase, TatD family'
BRM84_RS22855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM84_RS22875	COG2072	flavoprotein involved in K transport
BRM84_RS22925	COG4770	biotin carboxylase activity
BRM84_RS22930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRM84_RS22935	COG1960	acyl-CoA dehydrogenase activity
BRM84_RS22990	COG0523	cobalamin synthesis protein
BRM84_RS23000	COG0697	spore germination
BRM84_RS23010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRM84_RS23025	COG4771	TonB-dependent receptor
BRM84_RS23030	COG0457	Tetratricopeptide repeat
BRM84_RS23045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM84_RS23070	COG0519	Catalyzes the synthesis of GMP from XMP
BRM84_RS23070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRM84_RS23080	COG0805	protein transport
BRM84_RS23090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRM84_RS23100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRM84_RS23155	COG3661	Belongs to the glycosyl hydrolase 67 family
BRM84_RS23165	COG4948	Mandelate Racemase Muconate Lactonizing
BRM84_RS23175	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM84_RS23180	COG0246	Mannitol dehydrogenase
BRM84_RS23205	COG3693	PFAM glycoside hydrolase, family 10
BRM84_RS23230	COG2211	Major facilitator Superfamily
BRM84_RS23275	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRM84_RS23325	COG1846	Transcriptional regulator
BRM84_RS23330	COG1764	response to oxidative stress
BRM84_RS23430	COG3549	Plasmid maintenance system killer
BRM84_RS23440	COG1074	ATP-dependent DNA helicase activity
BRM84_RS23445	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRM84_RS23485	COG2032	superoxide dismutase activity
BRM84_RS23490	COG2032	superoxide dismutase activity
BRM84_RS23495	COG2204	response regulator
BRM84_RS23500	COG3852	Histidine kinase
BRM84_RS23505	COG0004	ammonium transporteR
BRM84_RS23510	COG0347	Belongs to the P(II) protein family
BRM84_RS23515	COG0174	glutamine synthetase
BRM84_RS23520	COG1968	undecaprenyl-diphosphatase activity
BRM84_RS23565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM84_RS23575	COG2062	phosphohistidine phosphatase, SixA
BRM84_RS23580	COG0489	protein tyrosine kinase activity
BRM84_RS23600	COG1396	sequence-specific DNA binding
BRM84_RS23605	COG3550	peptidyl-serine autophosphorylation
BRM84_RS23610	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRM84_RS23615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM84_RS23630	COG1125	glycine betaine transport
BRM84_RS23630	COG0517	IMP dehydrogenase activity
BRM84_RS23645	COG1119	ATPase activity
BRM84_RS23655	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRM84_RS23670	COG3039	Transposase
BRM84_RS23695	COG0656	L-ascorbic acid biosynthetic process
BRM84_RS23700	COG2130	NADP-dependent
BRM84_RS23705	COG0667	Aldo Keto reductase
BRM84_RS23715	COG1187	pseudouridine synthase activity
BRM84_RS23730	COG1643	Atp-dependent helicase
BRM84_RS23735	COG4807	Protein conserved in bacteria
BRM84_RS23740	COG4948	Mandelate Racemase Muconate Lactonizing
BRM84_RS23750	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRM84_RS23755	COG1028	Short-chain dehydrogenase reductase Sdr
BRM84_RS23775	COG3507	Belongs to the glycosyl hydrolase 43 family
BRM84_RS23820	COG3162	membrane
BRM84_RS23825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRM84_RS23840	COG0708	Exodeoxyribonuclease III
BRM84_RS23855	COG2091	lysine biosynthetic process via aminoadipic acid
BRM84_RS23865	COG3540	Alkaline phosphatase
BRM84_RS23895	COG2159	amidohydrolase
BRM84_RS23920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM84_RS23925	COG0583	DNA-binding transcription factor activity
BRM84_RS23930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM84_RS23950	COG0210	DNA helicase
BRM84_RS23965	COG0531	amino acid
BRM84_RS23975	COG1322	Protein conserved in bacteria
BRM84_RS23985	COG0386	Belongs to the glutathione peroxidase family
BRM84_RS24040	COG0793	Belongs to the peptidase S41A family
BRM84_RS24045	COG4942	peptidase
BRM84_RS24055	COG2234	aminopeptidase activity
BRM84_RS24105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRM84_RS24110	COG0302	gtp cyclohydrolase
BRM84_RS24135	COG0477	Major facilitator Superfamily
BRM84_RS24245	COG1929	Belongs to the glycerate kinase type-1 family
BRM84_RS24250	COG2271	Major facilitator Superfamily
BRM84_RS24265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM84_RS24275	COG0861	Integral membrane protein TerC family
BRM84_RS24285	COG0584	glycerophosphoryl diester phosphodiesterase
BRM84_RS24295	COG0671	phosphoesterase, PA-phosphatase related
BRM84_RS24305	COG0726	polysaccharide deacetylase