locus-tag	class	description
BRM88_RS00025	COG0187	DNA topoisomerase II activity
BRM88_RS00035	COG0501	Belongs to the peptidase M48B family
BRM88_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM88_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRM88_RS00095	COG4772	TonB-dependent receptor
BRM88_RS00110	COG3039	Transposase
BRM88_RS00115	COG1304	FMN binding
BRM88_RS00120	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRM88_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM88_RS00155	COG3039	Transposase
BRM88_RS00160	COG1136	(ABC) transporter
BRM88_RS00210	COG3039	Transposase
BRM88_RS00220	COG0513	Belongs to the DEAD box helicase family
BRM88_RS00325	COG1858	cytochrome C peroxidase
BRM88_RS00335	COG0702	epimerase
BRM88_RS00360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRM88_RS00380	COG1649	PFAM Uncharacterised BCR, COG1649
BRM88_RS00385	COG2354	Protein conserved in bacteria
BRM88_RS00395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM88_RS00410	COG1511	domain protein
BRM88_RS00410	COG3264	Mechanosensitive ion channel
BRM88_RS00490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRM88_RS00570	COG3039	Transposase
BRM88_RS00580	COG3039	Transposase
BRM88_RS00615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM88_RS00625	COG0642	Histidine kinase
BRM88_RS00635	COG1090	epimerase
BRM88_RS00645	COG3039	Transposase
BRM88_RS00670	COG2826	transposase and inactivated derivatives, IS30 family
BRM88_RS00735	COG1136	(ABC) transporter
BRM88_RS00780	COG1272	protein, Hemolysin III
BRM88_RS00785	COG1111	helicase
BRM88_RS00785	COG1205	dead DEAH box helicase
BRM88_RS00845	COG0067	glutamate synthase
BRM88_RS00845	COG0070	glutamate synthase
BRM88_RS00845	COG0069	glutamate synthase activity
BRM88_RS00850	COG0493	'glutamate synthase
BRM88_RS00900	COG1609	Transcriptional regulator
BRM88_RS00935	COG0366	Alpha amylase catalytic
BRM88_RS00940	COG0366	Alpha amylase catalytic
BRM88_RS00995	COG0606	chelatase, subunit chli
BRM88_RS01040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRM88_RS01045	COG1166	arginine decarboxylase activity
BRM88_RS01115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM88_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS01165	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRM88_RS01180	COG0210	DNA helicase
BRM88_RS01195	COG3132	Protein of unknown function, DUF480
BRM88_RS01200	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRM88_RS01205	COG0284	orotidine-5'-phosphate decarboxylase activity
BRM88_RS01240	COG2937	Belongs to the GPAT DAPAT family
BRM88_RS01270	COG2755	lipolytic protein G-D-S-L family
BRM88_RS01285	COG3186	Phenylalanine-4-hydroxylase
BRM88_RS01290	COG1522	sequence-specific DNA binding
BRM88_RS01340	COG1064	alcohol dehydrogenase
BRM88_RS01350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM88_RS01360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM88_RS01370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM88_RS01395	COG3039	Transposase
BRM88_RS01400	COG0676	glucose-6-phosphate 1-epimerase activity
BRM88_RS01465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRM88_RS01490	COG2853	Lipoprotein
BRM88_RS01505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM88_RS01510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM88_RS01515	COG1127	ABC transporter
BRM88_RS01590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM88_RS01605	COG3265	gluconokinase activity
BRM88_RS01610	COG2211	Major facilitator Superfamily
BRM88_RS01615	COG3459	Glycosyltransferase 36 associated
BRM88_RS01630	COG2205	protein histidine kinase activity
BRM88_RS01640	COG1414	Transcriptional regulator
BRM88_RS01645	COG0738	Major facilitator superfamily
BRM88_RS01650	COG3254	rhamnose metabolic process
BRM88_RS01680	COG0339	signal peptide processing
BRM88_RS01710	COG0564	pseudouridine synthase activity
BRM88_RS01720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRM88_RS01735	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRM88_RS01820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRM88_RS01830	COG0842	Transport permease protein
BRM88_RS01835	COG1131	(ABC) transporter
BRM88_RS01840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM88_RS01860	COG1476	TRANSCRIPTIONal
BRM88_RS01870	COG4555	ABC transporter
BRM88_RS01910	COG0625	glutathione transferase activity
BRM88_RS01960	COG0583	DNA-binding transcription factor activity
BRM88_RS01995	COG1199	ATP-dependent helicase activity
BRM88_RS02015	COG1566	PFAM secretion protein HlyD family protein
BRM88_RS02045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM88_RS02085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRM88_RS02085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRM88_RS02090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRM88_RS02105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRM88_RS02145	COG3237	CsbD-like
BRM88_RS02150	COG0180	Tryptophanyl-tRNA synthetase
BRM88_RS02155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM88_RS02205	COG0753	catalase activity
BRM88_RS02210	COG1595	DNA-templated transcription, initiation
BRM88_RS02220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM88_RS02230	COG0628	permease
BRM88_RS02245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRM88_RS02250	COG1040	competence protein
BRM88_RS02255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRM88_RS02260	COG0156	8-amino-7-oxononanoate synthase activity
BRM88_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS02290	COG0463	Glycosyl transferase, family 2
BRM88_RS02300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRM88_RS02305	COG3100	YcgL domain-containing protein
BRM88_RS02320	COG3387	PFAM Glycoside hydrolase 15-related
BRM88_RS02325	COG3387	PFAM Glycoside hydrolase 15-related
BRM88_RS02330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM88_RS02350	COG2239	Acts as a magnesium transporter
BRM88_RS02360	COG1042	CoA-binding domain protein
BRM88_RS02360	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM88_RS02360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRM88_RS02370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM88_RS02380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRM88_RS02415	COG3485	protocatechuate 3,4-dioxygenase
BRM88_RS02420	COG3485	protocatechuate 3,4-dioxygenase
BRM88_RS02435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM88_RS02440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRM88_RS02465	COG4221	oxidoreductase activity
BRM88_RS02490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRM88_RS02515	COG0463	Glycosyl transferase, family 2
BRM88_RS02530	COG1475	DNA binding
BRM88_RS02535	COG1192	Involved in chromosome partitioning
BRM88_RS02550	COG0708	Exodeoxyribonuclease III
BRM88_RS02555	COG2211	Major facilitator Superfamily
BRM88_RS02570	COG0739	heme binding
BRM88_RS02620	COG0745	RESPONSE REGULATOR receiver
BRM88_RS02660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRM88_RS02685	COG2814	Major facilitator Superfamily
BRM88_RS02700	COG1289	transmembrane transporter activity
BRM88_RS02710	COG1136	(ABC) transporter
BRM88_RS02710	COG0577	efflux transmembrane transporter activity
BRM88_RS02715	COG0151	Belongs to the GarS family
BRM88_RS02725	COG0419	ATPase involved in DNA repair
BRM88_RS02740	COG2267	carboxylic ester hydrolase activity
BRM88_RS02750	COG2267	carboxylic ester hydrolase activity
BRM88_RS02755	COG2453	phosphatase
BRM88_RS02755	COG0671	phosphoesterase, PA-phosphatase related
BRM88_RS02770	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRM88_RS02830	COG0439	Biotin carboxylase
BRM88_RS02840	COG0511	ligase activity, forming carbon-carbon bonds
BRM88_RS02845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRM88_RS02865	COG1324	tolerance protein
BRM88_RS02900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRM88_RS02925	COG0534	Mate efflux family protein
BRM88_RS02930	COG0616	signal peptide processing
BRM88_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS02955	COG0009	L-threonylcarbamoyladenylate synthase
BRM88_RS02960	COG1754	DNA topoisomerase type I activity
BRM88_RS02960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRM88_RS02975	COG2922	Belongs to the Smg family
BRM88_RS02980	COG0758	DNA mediated transformation
BRM88_RS02985	COG1652	LysM domain
BRM88_RS02990	COG0242	peptide deformylase activity
BRM88_RS02995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRM88_RS03000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM88_RS03000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRM88_RS03050	COG1560	Kdo2-lipid A biosynthetic process
BRM88_RS03060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM88_RS03215	COG1294	oxidase, subunit
BRM88_RS03220	COG1271	oxidase subunit
BRM88_RS03235	COG2204	response regulator
BRM88_RS03265	COG2972	Histidine kinase
BRM88_RS03280	COG0531	amino acid
BRM88_RS03300	COG3590	peptidase
BRM88_RS03315	COG0667	Aldo Keto reductase
BRM88_RS03330	COG3384	dioxygenase
BRM88_RS03340	COG1573	uracil-dna glycosylase
BRM88_RS03350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRM88_RS03365	COG0025	NhaP-type Na H and K H
BRM88_RS03370	COG1131	(ABC) transporter
BRM88_RS03375	COG0842	Transport permease protein
BRM88_RS03390	COG1404	Belongs to the peptidase S8 family
BRM88_RS03405	COG0745	RESPONSE REGULATOR receiver
BRM88_RS03455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM88_RS03480	COG2202	Pas domain
BRM88_RS03480	COG2205	protein histidine kinase activity
BRM88_RS03515	COG2813	Specifically methylates the guanine in position
BRM88_RS03520	COG1187	pseudouridine synthase activity
BRM88_RS03525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRM88_RS03560	COG0697	spore germination
BRM88_RS03570	COG2011	ABC-type metal ion transport system permease component
BRM88_RS03600	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRM88_RS03610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRM88_RS03630	COG0356	it plays a direct role in the translocation of protons across the membrane
BRM88_RS03640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRM88_RS03650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRM88_RS03655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRM88_RS03660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRM88_RS03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM88_RS03725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM88_RS03780	COG0339	signal peptide processing
BRM88_RS03820	COG1956	GAF domain-containing protein
BRM88_RS03825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRM88_RS03835	COG0720	synthase
BRM88_RS03845	COG0513	Belongs to the DEAD box helicase family
BRM88_RS03890	COG0626	cystathionine gamma-synthase activity
BRM88_RS03940	COG3328	transposase activity
BRM88_RS03965	COG2086	electron transfer activity
BRM88_RS03990	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRM88_RS03990	COG0662	Cupin 2, conserved barrel domain protein
BRM88_RS03995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM88_RS04035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRM88_RS04035	COG3218	ABC-type transport auxiliary lipoprotein component
BRM88_RS04040	COG1127	ABC transporter
BRM88_RS04045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRM88_RS04060	COG0442	prolyl-tRNA aminoacylation
BRM88_RS04070	COG1183	phosphatidylcholine synthase activity
BRM88_RS04100	COG3039	Transposase
BRM88_RS04170	COG0525	valine-tRNA ligase activity
BRM88_RS04185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRM88_RS04195	COG0795	lipopolysaccharide-transporting ATPase activity
BRM88_RS04210	COG4974	Belongs to the 'phage' integrase family
BRM88_RS04215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRM88_RS04220	COG0047	phosphoribosylformylglycinamidine synthase activity
BRM88_RS04220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRM88_RS04230	COG5295	Hep Hag repeat protein
BRM88_RS04250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM88_RS04260	COG1459	type II secretion system
BRM88_RS04265	COG2165	general secretion pathway protein
BRM88_RS04270	COG4970	Tfp pilus assembly protein FimT
BRM88_RS04275	COG2165	general secretion pathway protein
BRM88_RS04280	COG4795	General secretion pathway protein
BRM88_RS04285	COG3156	type II secretion system protein K
BRM88_RS04290	COG3166	PFAM Fimbrial assembly family protein
BRM88_RS04305	COG1450	Type ii and iii secretion system protein
BRM88_RS04320	COG2188	Transcriptional regulator
BRM88_RS04375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRM88_RS04380	COG1518	maintenance of DNA repeat elements
BRM88_RS04425	COG1399	metal-binding, possibly nucleic acid-binding protein
BRM88_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS04455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM88_RS04465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRM88_RS04470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRM88_RS04505	COG3829	transcription factor binding
BRM88_RS04540	COG3039	Transposase
BRM88_RS04600	COG2826	transposase and inactivated derivatives, IS30 family
BRM88_RS04610	COG0678	peroxiredoxin activity
BRM88_RS04630	COG0330	HflC and HflK could
BRM88_RS04635	COG0330	HflC and HflK could
BRM88_RS04650	COG0308	aminopeptidase N
BRM88_RS04700	COG1560	Kdo2-lipid A biosynthetic process
BRM88_RS04705	COG1519	Transferase
BRM88_RS04710	COG1538	Outer membrane efflux protein
BRM88_RS04715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM88_RS04740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRM88_RS04745	COG0066	3-isopropylmalate dehydratase activity
BRM88_RS04780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRM88_RS04790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRM88_RS04795	COG3710	Transcriptional regulator
BRM88_RS04820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRM88_RS04840	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRM88_RS04870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM88_RS04880	COG3781	membrane
BRM88_RS04900	COG0625	glutathione transferase activity
BRM88_RS04910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRM88_RS04915	COG1217	gtp-binding protein TYPA
BRM88_RS04935	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRM88_RS05070	COG3039	Transposase
BRM88_RS05095	COG0584	glycerophosphoryl diester phosphodiesterase
BRM88_RS05120	COG0473	3-isopropylmalate dehydrogenase activity
BRM88_RS05175	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRM88_RS05215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRM88_RS05240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM88_RS05250	COG0631	protein serine/threonine phosphatase activity
BRM88_RS05335	COG0582	viral genome integration into host DNA
BRM88_RS05345	COG0859	PFAM glycosyl transferase family 9
BRM88_RS05350	COG3642	lipopolysaccharide core region biosynthetic process
BRM88_RS05355	COG1234	tRNA 3'-trailer cleavage
BRM88_RS05360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRM88_RS05370	COG0315	cyclic pyranopterin monophosphate synthase activity
BRM88_RS05375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRM88_RS05380	COG0314	molybdopterin synthase activity
BRM88_RS05410	COG0537	adenosine 5'-monophosphoramidase activity
BRM88_RS05430	COG0714	Associated with various cellular activities
BRM88_RS05450	COG0242	peptide deformylase activity
BRM88_RS05500	COG3039	Transposase
BRM88_RS05530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM88_RS05535	COG0726	polysaccharide deacetylase
BRM88_RS05585	COG2211	Major facilitator Superfamily
BRM88_RS05595	COG1609	Transcriptional regulator
BRM88_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS05605	COG2851	Citrate transporter
BRM88_RS05625	COG0642	Histidine kinase
BRM88_RS05635	COG2197	response regulator
BRM88_RS05655	COG0583	DNA-binding transcription factor activity
BRM88_RS05670	COG4191	Histidine kinase
BRM88_RS05690	COG0280	phosphate acetyltransferase
BRM88_RS05690	COG0281	malic enzyme
BRM88_RS05725	COG0352	thiamine-phosphate diphosphorylase activity
BRM88_RS05730	COG1773	rubredoxin
BRM88_RS05735	COG2912	Transglutaminase-like superfamily
BRM88_RS05755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRM88_RS05780	COG0006	proline dipeptidase activity
BRM88_RS05815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRM88_RS05830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRM88_RS05835	COG1561	YicC-like family, N-terminal region
BRM88_RS05860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM88_RS05870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRM88_RS05895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRM88_RS05945	COG0714	Associated with various cellular activities
BRM88_RS05965	COG2304	oxidoreductase activity
BRM88_RS05985	COG1301	dicarboxylic acid transport
BRM88_RS05990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRM88_RS06000	COG0739	heme binding
BRM88_RS06005	COG1376	ErfK ybiS ycfS ynhG family protein
BRM88_RS06030	COG1022	Amp-dependent synthetase and ligase
BRM88_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS06055	COG0642	Histidine kinase
BRM88_RS06075	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRM88_RS06080	COG4149	molybdate abc transporter
BRM88_RS06085	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRM88_RS06090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRM88_RS06090	COG3453	Protein conserved in bacteria
BRM88_RS06125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRM88_RS06145	COG2205	protein histidine kinase activity
BRM88_RS06150	COG0745	RESPONSE REGULATOR receiver
BRM88_RS06200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM88_RS06205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRM88_RS06320	COG2201	protein-glutamate methylesterase activity
BRM88_RS06370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRM88_RS06385	COG1842	Phage shock protein A
BRM88_RS06410	COG0754	glutathionylspermidine amidase activity
BRM88_RS06480	COG0531	amino acid
BRM88_RS06485	COG2197	response regulator
BRM88_RS06500	COG1113	amino acid transport
BRM88_RS06520	COG1271	oxidase subunit
BRM88_RS06525	COG1294	oxidase, subunit
BRM88_RS06535	COG2239	Acts as a magnesium transporter
BRM88_RS06545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM88_RS06550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM88_RS06560	COG1660	Displays ATPase and GTPase activities
BRM88_RS06565	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRM88_RS06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM88_RS06585	COG1137	ATPase activity
BRM88_RS06590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRM88_RS06600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRM88_RS06610	COG0271	Belongs to the BolA IbaG family
BRM88_RS06620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRM88_RS06640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRM88_RS06655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRM88_RS06665	COG0628	permease
BRM88_RS06675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRM88_RS06680	COG3178	'Phosphotransferase
BRM88_RS06695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM88_RS06700	COG1555	photosystem II stabilization
BRM88_RS06745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM88_RS06755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRM88_RS06780	COG0228	four-way junction DNA binding
BRM88_RS06785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRM88_RS06790	COG0336	Belongs to the RNA methyltransferase TrmD family
BRM88_RS06805	COG0534	Mate efflux family protein
BRM88_RS06845	COG0542	response to heat
BRM88_RS06885	COG4206	TonB-dependent receptor
BRM88_RS06945	COG0019	diaminopimelate decarboxylase activity
BRM88_RS06955	COG2814	Major facilitator Superfamily
BRM88_RS06960	COG4264	IucA IucC family
BRM88_RS06970	COG4772	TonB-dependent receptor
BRM88_RS06985	COG4651	solute:proton antiporter activity
BRM88_RS06985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRM88_RS07020	COG0488	(ABC) transporter
BRM88_RS07045	COG0657	acetylesterase activity
BRM88_RS07045	COG2755	lipolytic protein G-D-S-L family
BRM88_RS07065	COG2207	Transcriptional regulator
BRM88_RS07070	COG0326	Molecular chaperone. Has ATPase activity
BRM88_RS07100	COG3328	transposase activity
BRM88_RS07105	COG0174	glutamine synthetase
BRM88_RS07110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRM88_RS07120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRM88_RS07135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM88_RS07165	COG2146	nitrite reductase [NAD(P)H] activity
BRM88_RS07180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRM88_RS07185	COG0719	Fe-S assembly protein
BRM88_RS07190	COG0396	ATPase activity
BRM88_RS07195	COG0719	Fe-S assembly protein
BRM88_RS07200	COG1959	2 iron, 2 sulfur cluster binding
BRM88_RS07220	COG0693	protein deglycase activity
BRM88_RS07255	COG3039	Transposase
BRM88_RS07275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRM88_RS07310	COG0519	Catalyzes the synthesis of GMP from XMP
BRM88_RS07320	COG1678	Uncharacterized ACR, COG1678
BRM88_RS07325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRM88_RS07340	COG1764	response to oxidative stress
BRM88_RS07350	COG0384	phenazine biosynthesis protein PhzF
BRM88_RS07360	COG0527	aspartate kinase activity
BRM88_RS07390	COG0142	geranyltranstransferase activity
BRM88_RS07395	COG0629	single-stranded DNA binding
BRM88_RS07400	COG5001	Diguanylate cyclase
BRM88_RS07400	COG3706	GGDEF domain
BRM88_RS07400	COG2203	Gaf domain
BRM88_RS07400	COG4251	negative regulation of phosphorylation
BRM88_RS07440	COG2879	small protein
BRM88_RS07445	COG1966	Carbon starvation protein
BRM88_RS07450	COG1741	Belongs to the pirin family
BRM88_RS07480	COG3039	Transposase
BRM88_RS07580	COG1741	Belongs to the pirin family
BRM88_RS07590	COG1515	deoxyribonuclease V activity
BRM88_RS07610	COG3590	peptidase
BRM88_RS07625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRM88_RS07630	COG2200	EAL domain
BRM88_RS07630	COG2199	diguanylate cyclase activity
BRM88_RS07630	COG2202	Pas domain
BRM88_RS07635	COG0835	chemotaxis
BRM88_RS07640	COG0840	transmembrane signaling receptor activity
BRM88_RS07645	COG2198	Histidine kinase
BRM88_RS07645	COG0643	Histidine kinase
BRM88_RS07655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRM88_RS07665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRM88_RS07685	COG2205	protein histidine kinase activity
BRM88_RS07710	COG3039	Transposase
BRM88_RS07735	COG3039	Transposase
BRM88_RS07770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRM88_RS07775	COG0735	belongs to the Fur family
BRM88_RS07835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRM88_RS07840	COG0084	hydrolase, TatD family'
BRM88_RS07855	COG1960	acyl-CoA dehydrogenase activity
BRM88_RS07870	COG0367	asparagine synthase
BRM88_RS07880	COG0305	Participates in initiation and elongation during chromosome replication
BRM88_RS07885	COG0415	Belongs to the DNA photolyase family
BRM88_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS07950	COG3039	Transposase
BRM88_RS08010	COG5001	Diguanylate cyclase
BRM88_RS08010	COG5002	protein histidine kinase activity
BRM88_RS08015	COG1187	pseudouridine synthase activity
BRM88_RS08040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM88_RS08050	COG0475	glutathione-regulated potassium exporter activity
BRM88_RS08055	COG5002	protein histidine kinase activity
BRM88_RS08055	COG5000	phosphorelay sensor kinase activity
BRM88_RS08060	COG0745	RESPONSE REGULATOR receiver
BRM88_RS08090	COG1132	(ABC) transporter
BRM88_RS08115	COG3039	Transposase
BRM88_RS08130	COG3039	Transposase
BRM88_RS08175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRM88_RS08185	COG4969	Belongs to the N-Me-Phe pilin family
BRM88_RS08190	COG2194	sulfuric ester hydrolase activity
BRM88_RS08230	COG0045	succinate-CoA ligase (ADP-forming) activity
BRM88_RS08235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRM88_RS08250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM88_RS08250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRM88_RS08255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM88_RS08260	COG0564	pseudouridine synthase activity
BRM88_RS08285	COG3387	PFAM Glycoside hydrolase 15-related
BRM88_RS08290	COG1877	trehalose-phosphatase activity
BRM88_RS08330	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BRM88_RS08350	COG1595	DNA-templated transcription, initiation
BRM88_RS08360	COG1946	Acyl-CoA thioesterase
BRM88_RS08375	COG0824	Thioesterase
BRM88_RS08380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRM88_RS08390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRM88_RS08395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRM88_RS08400	COG0268	Binds directly to 16S ribosomal RNA
BRM88_RS08405	COG0728	peptidoglycan biosynthetic process
BRM88_RS08410	COG0196	riboflavin kinase activity
BRM88_RS08420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRM88_RS08425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRM88_RS08440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRM88_RS08445	COG1845	cytochrome c oxidase, subunit III
BRM88_RS08450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRM88_RS08470	COG3209	COG3209 Rhs family protein
BRM88_RS08470	COG3209	COG3209 Rhs family protein
BRM88_RS08590	COG0632	four-way junction helicase activity
BRM88_RS08600	COG2255	four-way junction helicase activity
BRM88_RS08605	COG0824	Thioesterase
BRM88_RS08615	COG0848	biopolymer transport protein
BRM88_RS08630	COG2885	chlorophyll binding
BRM88_RS08640	COG0602	queuosine metabolic process
BRM88_RS08650	COG1187	pseudouridine synthase activity
BRM88_RS08710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRM88_RS08880	COG3179	chitinase
BRM88_RS08925	COG4695	Portal protein
BRM88_RS08965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BRM88_RS08995	COG0514	ATP-dependent DNA helicase (RecQ)
BRM88_RS09005	COG0783	Belongs to the Dps family
BRM88_RS09010	COG1643	Atp-dependent helicase
BRM88_RS09065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRM88_RS09075	COG1215	transferase activity, transferring glycosyl groups
BRM88_RS09080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRM88_RS09090	COG1199	ATP-dependent helicase activity
BRM88_RS09100	COG1397	ADP-ribosylglycohydrolase
BRM88_RS09110	COG0189	ligase activity
BRM88_RS09125	COG0835	chemotaxis
BRM88_RS09130	COG0840	transmembrane signaling receptor activity
BRM88_RS09135	COG2198	Histidine kinase
BRM88_RS09135	COG0784	Response regulator, receiver
BRM88_RS09135	COG0643	Histidine kinase
BRM88_RS09180	COG1446	asparaginase
BRM88_RS09185	COG3142	Participates in the control of copper homeostasis
BRM88_RS09240	COG3537	Alpha-1,2-mannosidase
BRM88_RS09310	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM88_RS09330	COG3858	chitin binding
BRM88_RS09330	COG1388	LysM domain
BRM88_RS09345	COG0837	glucose binding
BRM88_RS09350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRM88_RS09360	COG0494	nUDIX hydrolase
BRM88_RS09370	COG3956	TIGRFAM MazG family protein
BRM88_RS09385	COG0330	HflC and HflK could
BRM88_RS09400	COG0509	glycine decarboxylation via glycine cleavage system
BRM88_RS09435	COG1960	acyl-CoA dehydrogenase activity
BRM88_RS09445	COG1309	transcriptional regulator
BRM88_RS09450	COG4771	TonB-dependent receptor
BRM88_RS09460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRM88_RS09470	COG0463	Glycosyl transferase, family 2
BRM88_RS09490	COG1272	protein, Hemolysin III
BRM88_RS09500	COG0739	heme binding
BRM88_RS09505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM88_RS09510	COG0626	cystathionine gamma-synthase activity
BRM88_RS09520	COG1760	l-serine dehydratase
BRM88_RS09535	COG2353	YceI-like domain
BRM88_RS09545	COG2353	YceI-like domain
BRM88_RS09595	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BRM88_RS09615	COG1960	acyl-CoA dehydrogenase activity
BRM88_RS09620	COG1024	Enoyl-CoA hydratase
BRM88_RS09640	COG1024	Enoyl-CoA hydratase
BRM88_RS09640	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM88_RS09655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRM88_RS09685	COG1381	Involved in DNA repair and RecF pathway recombination
BRM88_RS09700	COG2954	triphosphatase activity
BRM88_RS09715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRM88_RS09720	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRM88_RS09725	COG3046	protein related to deoxyribodipyrimidine photolyase
BRM88_RS09735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BRM88_RS09740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRM88_RS09745	COG1278	Cold shock
BRM88_RS09765	COG1201	RNA secondary structure unwinding
BRM88_RS09770	COG1793	dna ligase
BRM88_RS09780	COG1793	dna ligase
BRM88_RS09780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRM88_RS09810	COG0183	Belongs to the thiolase family
BRM88_RS09835	COG1451	nucleotide metabolic process
BRM88_RS09850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRM88_RS09895	COG1047	Peptidyl-prolyl cis-trans
BRM88_RS09910	COG2824	Alkylphosphonate utilization operon protein PhnA
BRM88_RS09925	COG1902	pentaerythritol trinitrate reductase activity
BRM88_RS09930	COG2814	Major facilitator Superfamily
BRM88_RS09985	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRM88_RS09985	COG0392	lysyltransferase activity
BRM88_RS09995	COG0251	oxidation-reduction process
BRM88_RS10000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM88_RS10015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRM88_RS10040	COG1595	DNA-templated transcription, initiation
BRM88_RS10060	COG2878	Part of a membrane complex involved in electron transport
BRM88_RS10070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM88_RS10070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRM88_RS10090	COG0833	amino acid
BRM88_RS10095	COG2040	homocysteine
BRM88_RS10110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM88_RS10145	COG0529	Catalyzes the synthesis of activated sulfate
BRM88_RS10145	COG2895	sulfate adenylyltransferase (ATP) activity
BRM88_RS10190	COG1981	membrane
BRM88_RS10215	COG1131	(ABC) transporter
BRM88_RS10220	COG4771	TonB-dependent receptor
BRM88_RS10230	COG0825	malonyl-CoA metabolic process
BRM88_RS10250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM88_RS10255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM88_RS10275	COG0750	zinc metalloprotease
BRM88_RS10285	COG0575	Belongs to the CDS family
BRM88_RS10295	COG0233	cytoplasmic translational termination
BRM88_RS10310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRM88_RS10370	COG1393	Belongs to the ArsC family
BRM88_RS10385	COG0367	asparagine synthase
BRM88_RS10400	COG4774	siderophore transport
BRM88_RS10440	COG1566	PFAM secretion protein HlyD family protein
BRM88_RS10445	COG2814	Major facilitator Superfamily
BRM88_RS10490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRM88_RS10500	COG1960	acyl-CoA dehydrogenase activity
BRM88_RS10525	COG2914	Belongs to the UPF0125 (RnfH) family
BRM88_RS10535	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM88_RS10545	COG0497	DNA recombination
BRM88_RS10555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRM88_RS10560	COG0443	Heat shock 70 kDa protein
BRM88_RS10565	COG0484	heat shock protein binding
BRM88_RS10575	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRM88_RS10580	COG1605	Chorismate mutase
BRM88_RS10580	COG0287	Prephenate dehydrogenase
BRM88_RS10600	COG0583	DNA-binding transcription factor activity
BRM88_RS10615	COG1132	(ABC) transporter
BRM88_RS10650	COG2850	peptidyl-arginine hydroxylation
BRM88_RS10730	COG1131	(ABC) transporter
BRM88_RS10735	COG1725	Transcriptional regulator
BRM88_RS10745	COG0386	Belongs to the glutathione peroxidase family
BRM88_RS10760	COG2900	Belongs to the SlyX family
BRM88_RS10775	COG1609	Transcriptional regulator
BRM88_RS10785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM88_RS10795	COG0646	methionine synthase
BRM88_RS10795	COG1410	methionine synthase
BRM88_RS10800	COG1410	methionine synthase
BRM88_RS10800	COG0646	methionine synthase
BRM88_RS10805	COG2226	methyltransferase
BRM88_RS10810	COG1960	acyl-CoA dehydrogenase activity
BRM88_RS10840	COG0557	exoribonuclease II activity
BRM88_RS10860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM88_RS10875	COG3039	Transposase
BRM88_RS10900	COG3328	transposase activity
BRM88_RS10910	COG1278	Cold shock
BRM88_RS10925	COG3039	Transposase
BRM88_RS10985	COG3039	Transposase
BRM88_RS11035	COG3039	Transposase
BRM88_RS11045	COG0583	DNA-binding transcription factor activity
BRM88_RS11105	COG2201	protein-glutamate methylesterase activity
BRM88_RS11140	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BRM88_RS11150	COG0531	amino acid
BRM88_RS11155	COG0531	amino acid
BRM88_RS11165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRM88_RS11170	COG0277	FAD linked oxidase domain protein
BRM88_RS11235	COG0436	Aminotransferase
BRM88_RS11260	COG1187	pseudouridine synthase activity
BRM88_RS11265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRM88_RS11270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRM88_RS11275	COG2350	Protein conserved in bacteria
BRM88_RS11305	COG1175	transmembrane transport
BRM88_RS11310	COG0395	ABC-type sugar transport system, permease component
BRM88_RS11335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRM88_RS11345	COG2957	Belongs to the agmatine deiminase family
BRM88_RS11360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRM88_RS11365	COG0539	negative regulation of cytoplasmic translation
BRM88_RS11370	COG0776	regulation of translation
BRM88_RS11380	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRM88_RS11385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRM88_RS11395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRM88_RS11415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRM88_RS11430	COG3002	Belongs to the UPF0753 family
BRM88_RS11435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM88_RS11440	COG0583	DNA-binding transcription factor activity
BRM88_RS11470	COG0583	DNA-binding transcription factor activity
BRM88_RS11495	COG1914	H( )-stimulated, divalent metal cation uptake system
BRM88_RS11515	COG0668	transmembrane transport
BRM88_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS11545	COG1183	phosphatidylcholine synthase activity
BRM88_RS11555	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRM88_RS11570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM88_RS11570	COG0723	plastoquinol--plastocyanin reductase activity
BRM88_RS11580	COG2183	response to ionizing radiation
BRM88_RS11595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRM88_RS11610	COG0671	phosphoesterase, PA-phosphatase related
BRM88_RS11635	COG1794	racemase activity, acting on amino acids and derivatives
BRM88_RS11640	COG0697	spore germination
BRM88_RS11665	COG1012	belongs to the aldehyde dehydrogenase family
BRM88_RS11700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRM88_RS11715	COG0124	histidyl-tRNA synthetase
BRM88_RS11735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRM88_RS11750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BRM88_RS11750	COG0131	Imidazoleglycerol-phosphate dehydratase
BRM88_RS11760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRM88_RS11770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRM88_RS11770	COG0140	phosphoribosyl-ATP diphosphatase activity
BRM88_RS11810	COG0653	protein targeting
BRM88_RS12025	COG2201	protein-glutamate methylesterase activity
BRM88_RS12035	COG2801	Transposase and inactivated derivatives
BRM88_RS12050	COG3039	Transposase
BRM88_RS12075	COG3328	transposase activity
BRM88_RS12110	COG0322	excinuclease ABC activity
BRM88_RS12120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRM88_RS12130	COG1663	tetraacyldisaccharide 4'-kinase activity
BRM88_RS12145	COG0811	peptide transport
BRM88_RS12175	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRM88_RS12190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRM88_RS12205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRM88_RS12220	COG0354	folic acid binding
BRM88_RS12235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRM88_RS12245	COG0363	glucosamine-6-phosphate deaminase activity
BRM88_RS12250	COG0129	dihydroxy-acid dehydratase activity
BRM88_RS12255	COG0800	Aldolase
BRM88_RS12285	COG0784	Response regulator, receiver
BRM88_RS12285	COG2205	protein histidine kinase activity
BRM88_RS12285	COG5002	protein histidine kinase activity
BRM88_RS12380	COG0386	Belongs to the glutathione peroxidase family
BRM88_RS12470	COG2203	Gaf domain
BRM88_RS12470	COG4251	negative regulation of phosphorylation
BRM88_RS12470	COG5001	Diguanylate cyclase
BRM88_RS12470	COG3706	GGDEF domain
BRM88_RS12490	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM88_RS12540	COG0617	tRNA 3'-terminal CCA addition
BRM88_RS12550	COG1469	GTP cyclohydrolase I activity
BRM88_RS12555	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM88_RS12610	COG4566	intracellular signal transduction
BRM88_RS12650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRM88_RS12655	COG0077	Prephenate dehydratase
BRM88_RS12655	COG1605	Chorismate mutase
BRM88_RS12665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRM88_RS12710	COG1228	amidohydrolase
BRM88_RS12715	COG2986	histidine ammonia-lyase
BRM88_RS12725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRM88_RS12750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRM88_RS12765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRM88_RS12780	COG3115	cell septum assembly
BRM88_RS12790	COG0359	binds to the 23S rRNA
BRM88_RS12800	COG0360	Binds together with S18 to 16S ribosomal RNA
BRM88_RS12805	COG0316	Belongs to the HesB IscA family
BRM88_RS12840	COG0288	reversible hydration of carbon dioxide
BRM88_RS12865	COG2925	Exonuclease
BRM88_RS12875	COG0667	Aldo Keto reductase
BRM88_RS12900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM88_RS12900	COG0116	Belongs to the methyltransferase superfamily
BRM88_RS12945	COG0494	nUDIX hydrolase
BRM88_RS12955	COG1024	Enoyl-CoA hydratase
BRM88_RS12965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRM88_RS12980	COG3039	Transposase
BRM88_RS13020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRM88_RS13025	COG0573	inorganic phosphate transmembrane transporter activity
BRM88_RS13040	COG0704	Plays a role in the regulation of phosphate uptake
BRM88_RS13050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRM88_RS13065	COG3328	transposase activity
BRM88_RS13100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM88_RS13105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRM88_RS13110	COG1862	Preprotein translocase
BRM88_RS13115	COG0343	queuine tRNA-ribosyltransferase activity
BRM88_RS13200	COG0405	Gamma-glutamyltransferase
BRM88_RS13205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRM88_RS13220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRM88_RS13225	COG0742	ribosomal rna small subunit methyltransferase
BRM88_RS13245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRM88_RS13275	COG3039	Transposase
BRM88_RS13285	COG3039	Transposase
BRM88_RS13315	COG0303	'Molybdopterin
BRM88_RS13325	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRM88_RS13335	COG1426	Protein conserved in bacteria
BRM88_RS13345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRM88_RS13360	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRM88_RS13360	COG1024	Enoyl-CoA hydratase
BRM88_RS13365	COG0183	Belongs to the thiolase family
BRM88_RS13370	COG0038	chloride channel
BRM88_RS13390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRM88_RS13415	COG1674	ftsk spoiiie
BRM88_RS13420	COG0492	ferredoxin-NADP+ reductase activity
BRM88_RS13445	COG0542	response to heat
BRM88_RS13485	COG5001	Diguanylate cyclase
BRM88_RS13490	COG4585	Histidine kinase
BRM88_RS13500	COG5002	protein histidine kinase activity
BRM88_RS13520	COG0835	chemotaxis
BRM88_RS13520	COG0784	Response regulator, receiver
BRM88_RS13530	COG1558	bacterial-type flagellum-dependent cell motility
BRM88_RS13535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRM88_RS13545	COG4787	bacterial-type flagellum-dependent cell motility
BRM88_RS13585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRM88_RS13590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRM88_RS13620	COG2201	protein-glutamate methylesterase activity
BRM88_RS13640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM88_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS13685	COG1677	Flagellar hook-basal body complex protein FliE
BRM88_RS13735	COG3190	flagellar
BRM88_RS13755	COG1684	flagellar biosynthetic protein fliR
BRM88_RS13810	COG2198	Histidine kinase
BRM88_RS13810	COG0784	Response regulator, receiver
BRM88_RS13810	COG0643	Histidine kinase
BRM88_RS13850	COG3039	Transposase
BRM88_RS13860	COG3209	COG3209 Rhs family protein
BRM88_RS13870	COG3039	Transposase
BRM88_RS13880	COG3039	Transposase
BRM88_RS13975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRM88_RS13980	COG4988	ABC transporter
BRM88_RS14005	COG1271	oxidase subunit
BRM88_RS14040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRM88_RS14060	COG0165	Argininosuccinate lyase
BRM88_RS14075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRM88_RS14080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRM88_RS14090	COG0137	argininosuccinate synthase activity
BRM88_RS14095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRM88_RS14110	COG2166	iron-sulfur cluster assembly
BRM88_RS14135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRM88_RS14185	COG3039	Transposase
BRM88_RS14200	COG4677	pectinesterase activity
BRM88_RS14230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRM88_RS14235	COG0402	S-adenosylhomocysteine deaminase activity
BRM88_RS14250	COG1509	lysine 2,3-aminomutase activity
BRM88_RS14255	COG3300	MHYT domain
BRM88_RS14255	COG5001	Diguanylate cyclase
BRM88_RS14270	COG0483	inositol monophosphate 1-phosphatase activity
BRM88_RS14275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM88_RS14300	COG0488	(ABC) transporter
BRM88_RS14305	COG0513	Belongs to the DEAD box helicase family
BRM88_RS14325	COG0625	glutathione transferase activity
BRM88_RS14335	COG1671	Belongs to the UPF0178 family
BRM88_RS14340	COG4681	YaeQ
BRM88_RS14345	COG2081	HI0933 family
BRM88_RS14365	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS14390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRM88_RS14395	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRM88_RS14400	COG0802	atpase or kinase
BRM88_RS14405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRM88_RS14405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRM88_RS14410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM88_RS14430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM88_RS14515	COG3328	transposase activity
BRM88_RS14560	COG2969	positive regulation of protein catabolic process
BRM88_RS14565	COG0625	glutathione transferase activity
BRM88_RS14570	COG2857	Cytochrome c1
BRM88_RS14575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRM88_RS14580	COG0723	plastoquinol--plastocyanin reductase activity
BRM88_RS14590	COG0741	lytic transglycosylase activity
BRM88_RS14615	COG1702	phosphate starvation-inducible protein PhoH
BRM88_RS14635	COG4535	Mg2 and Co2 transporter CorC
BRM88_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
BRM88_RS14660	COG1177	transmembrane transport
BRM88_RS14670	COG3842	ATPase activity
BRM88_RS14710	COG0174	glutamine synthetase
BRM88_RS14715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM88_RS14725	COG0477	Major facilitator Superfamily
BRM88_RS14735	COG0243	molybdopterin cofactor binding
BRM88_RS14745	COG2223	nitrite transmembrane transporter activity
BRM88_RS14765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRM88_RS14770	COG1121	(ABC) transporter
BRM88_RS14780	COG2733	membrane
BRM88_RS14785	COG2205	protein histidine kinase activity
BRM88_RS14785	COG0784	Response regulator, receiver
BRM88_RS14785	COG5002	protein histidine kinase activity
BRM88_RS14795	COG3039	Transposase
BRM88_RS14805	COG2902	Dehydrogenase
BRM88_RS14815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM88_RS14820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM88_RS14845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRM88_RS14845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRM88_RS14850	COG1105	Belongs to the carbohydrate kinase PfkB family
BRM88_RS14855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM88_RS14855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRM88_RS14865	COG3039	Transposase
BRM88_RS14875	COG3039	Transposase
BRM88_RS14950	COG3039	Transposase
BRM88_RS15015	COG3039	Transposase
BRM88_RS15045	COG4771	TonB-dependent receptor
BRM88_RS15055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRM88_RS15075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRM88_RS15080	COG1360	Flagellar Motor Protein
BRM88_RS15090	COG0835	chemotaxis
BRM88_RS15100	COG0745	RESPONSE REGULATOR receiver
BRM88_RS15125	COG0840	transmembrane signaling receptor activity
BRM88_RS15140	COG0840	transmembrane signaling receptor activity
BRM88_RS15150	COG0840	transmembrane signaling receptor activity
BRM88_RS15160	COG0840	transmembrane signaling receptor activity
BRM88_RS15165	COG0840	transmembrane signaling receptor activity
BRM88_RS15170	COG0840	transmembrane signaling receptor activity
BRM88_RS15175	COG0840	transmembrane signaling receptor activity
BRM88_RS15195	COG0835	chemotaxis
BRM88_RS15220	COG0840	transmembrane signaling receptor activity
BRM88_RS15255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRM88_RS15285	COG0318	PFAM AMP-dependent synthetase and ligase
BRM88_RS15290	COG1024	Enoyl-CoA hydratase
BRM88_RS15295	COG0784	Response regulator, receiver
BRM88_RS15295	COG2205	protein histidine kinase activity
BRM88_RS15295	COG2198	Histidine kinase
BRM88_RS15370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRM88_RS15380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM88_RS15385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRM88_RS15395	COG0505	Belongs to the CarA family
BRM88_RS15400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRM88_RS15410	COG2258	MOSC domain
BRM88_RS15415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRM88_RS15465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRM88_RS15485	COG0477	Major facilitator Superfamily
BRM88_RS15495	COG1070	Carbohydrate kinase
BRM88_RS15505	COG1501	Belongs to the glycosyl hydrolase 31 family
BRM88_RS15520	COG0800	Aldolase
BRM88_RS15525	COG4948	Mandelate Racemase Muconate Lactonizing
BRM88_RS15535	COG3734	2-keto-3-deoxy-galactonokinase
BRM88_RS15540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRM88_RS15550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM88_RS15565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRM88_RS15570	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRM88_RS15580	COG0351	phosphomethylpyrimidine kinase
BRM88_RS15610	COG0583	DNA-binding transcription factor activity
BRM88_RS15615	COG1741	Belongs to the pirin family
BRM88_RS15635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRM88_RS15640	COG0305	Participates in initiation and elongation during chromosome replication
BRM88_RS15665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRM88_RS15670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRM88_RS15675	COG2137	regulation of response to DNA damage stimulus
BRM88_RS15685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRM88_RS15700	COG1546	Belongs to the CinA family
BRM88_RS15705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRM88_RS15720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRM88_RS15730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRM88_RS15735	COG1534	Rna-binding protein
BRM88_RS15750	COG1238	metal cluster binding
BRM88_RS15755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRM88_RS15760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRM88_RS15765	COG2840	Smr protein MutS2
BRM88_RS15780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRM88_RS15795	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRM88_RS15800	COG0148	phosphopyruvate hydratase activity
BRM88_RS15810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRM88_RS15815	COG0504	CTP synthase activity
BRM88_RS15840	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BRM88_RS15845	COG0306	phosphate transporter
BRM88_RS15860	COG1253	flavin adenine dinucleotide binding
BRM88_RS15875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRM88_RS15895	COG0477	Major facilitator Superfamily
BRM88_RS15905	COG1132	(ABC) transporter
BRM88_RS15910	COG1136	(ABC) transporter
BRM88_RS15930	COG0438	transferase activity, transferring glycosyl groups
BRM88_RS15940	COG2264	protein methyltransferase activity
BRM88_RS15970	COG2244	polysaccharide biosynthetic process
BRM88_RS16020	COG1595	DNA-templated transcription, initiation
BRM88_RS16035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRM88_RS16055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM88_RS16105	COG2201	protein-glutamate methylesterase activity
BRM88_RS16125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM88_RS16130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM88_RS16185	COG1858	cytochrome C peroxidase
BRM88_RS16220	COG0515	serine threonine protein kinase
BRM88_RS16225	COG0631	protein serine/threonine phosphatase activity
BRM88_RS16335	COG3039	Transposase
BRM88_RS16355	COG3039	Transposase
BRM88_RS16415	COG0428	transporter
BRM88_RS16420	COG0428	transporter
BRM88_RS16425	COG3064	Membrane
BRM88_RS16435	COG1530	ribonuclease E activity
BRM88_RS16455	COG1054	Belongs to the UPF0176 family
BRM88_RS16460	COG3039	Transposase
BRM88_RS16480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRM88_RS16520	COG3039	Transposase
BRM88_RS16525	COG3039	Transposase
BRM88_RS16555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRM88_RS16555	COG1648	precorrin-2 dehydrogenase activity
BRM88_RS16580	COG0746	molybdenum cofactor guanylyltransferase activity
BRM88_RS16655	COG3328	transposase activity
BRM88_RS16660	COG4206	TonB-dependent receptor
BRM88_RS16695	COG4206	TonB-dependent receptor
BRM88_RS16745	COG0531	amino acid
BRM88_RS16760	COG0006	proline dipeptidase activity
BRM88_RS16770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRM88_RS16785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM88_RS16790	COG3938	Belongs to the proline racemase family
BRM88_RS16800	COG0552	protein localization to endoplasmic reticulum
BRM88_RS16825	COG0784	Response regulator, receiver
BRM88_RS16825	COG4191	Histidine kinase
BRM88_RS16915	COG3040	lipid binding
BRM88_RS16955	COG0438	transferase activity, transferring glycosyl groups
BRM88_RS16965	COG0438	transferase activity, transferring glycosyl groups
BRM88_RS16970	COG0438	transferase activity, transferring glycosyl groups
BRM88_RS17040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRM88_RS17080	COG4969	Belongs to the N-Me-Phe pilin family
BRM88_RS17120	COG1611	Belongs to the LOG family
BRM88_RS17135	COG2095	MarC family integral membrane protein
BRM88_RS17145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRM88_RS17180	COG1185	polyribonucleotide nucleotidyltransferase activity
BRM88_RS17185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRM88_RS17205	COG0195	Participates in both transcription termination and antitermination
BRM88_RS17210	COG0779	Required for maturation of 30S ribosomal subunits
BRM88_RS17220	COG1007	ATP synthesis coupled electron transport
BRM88_RS17255	COG1034	ATP synthesis coupled electron transport
BRM88_RS17260	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRM88_RS17265	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRM88_RS17270	COG0649	NAD binding
BRM88_RS17275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM88_RS17285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRM88_RS17300	COG0149	triose-phosphate isomerase activity
BRM88_RS17350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRM88_RS17355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRM88_RS17380	COG0135	phosphoribosylanthranilate isomerase activity
BRM88_RS17385	COG0101	tRNA pseudouridine synthase activity
BRM88_RS17405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRM88_RS17410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRM88_RS17415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRM88_RS17420	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM88_RS17475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM88_RS17485	COG0412	Dienelactone hydrolase
BRM88_RS17505	COG0717	Belongs to the dCTP deaminase family
BRM88_RS17510	COG0489	protein tyrosine kinase activity
BRM88_RS17555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRM88_RS17560	COG2311	Membrane
BRM88_RS17565	COG1047	Peptidyl-prolyl cis-trans
BRM88_RS17570	COG0791	NLP P60 protein
BRM88_RS17575	COG0791	NLP P60 protein
BRM88_RS17590	COG1301	dicarboxylic acid transport
BRM88_RS17595	COG1785	Belongs to the alkaline phosphatase family
BRM88_RS17600	COG0037	tRNA processing
BRM88_RS17605	COG1722	exodeoxyribonuclease VII activity
BRM88_RS17610	COG0142	geranyltranstransferase activity
BRM88_RS17635	COG0312	modulator of DNA gyrase
BRM88_RS17640	COG3028	Belongs to the UPF0307 family
BRM88_RS17645	COG0312	modulator of DNA gyrase
BRM88_RS17655	COG3164	Protein of unknown function
BRM88_RS17670	COG2968	Membrane
BRM88_RS17695	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRM88_RS17720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRM88_RS17750	COG3118	belongs to the thioredoxin family
BRM88_RS17835	COG3039	Transposase
BRM88_RS17840	COG3039	Transposase
BRM88_RS17935	COG2022	thiamine diphosphate biosynthetic process
BRM88_RS17950	COG0471	metal ion transport
BRM88_RS17950	COG3273	potassium ion transport
BRM88_RS17980	COG1970	mechanosensitive ion channel activity
BRM88_RS18005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRM88_RS18035	COG0308	aminopeptidase N
BRM88_RS18040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM88_RS18055	COG2895	sulfate adenylyltransferase (ATP) activity
BRM88_RS18055	COG0529	Catalyzes the synthesis of activated sulfate
BRM88_RS18060	COG0175	sulfate reduction
BRM88_RS18065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRM88_RS18070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRM88_RS18075	COG0175	sulfate reduction
BRM88_RS18095	COG2205	protein histidine kinase activity
BRM88_RS18095	COG0784	Response regulator, receiver
BRM88_RS18095	COG2198	Histidine kinase
BRM88_RS18140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRM88_RS18145	COG3588	fructose-bisphosphate aldolase
BRM88_RS18150	COG0469	pyruvate kinase activity
BRM88_RS18195	COG0753	catalase activity
BRM88_RS18220	COG3039	Transposase
BRM88_RS18240	COG1917	Cupin 2, conserved barrel domain protein
BRM88_RS18240	COG2207	Transcriptional regulator
BRM88_RS18270	COG0823	Involved in the tonB-independent uptake of proteins
BRM88_RS18270	COG1506	peptidase
BRM88_RS18295	COG3039	Transposase
BRM88_RS18300	COG1297	OPT oligopeptide transporter protein
BRM88_RS18405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRM88_RS18425	COG3039	Transposase
BRM88_RS18430	COG0732	type I restriction modification DNA specificity domain
BRM88_RS18435	COG3039	Transposase
BRM88_RS18445	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRM88_RS18450	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRM88_RS18470	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRM88_RS18690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM88_RS18820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRM88_RS18835	COG2197	response regulator
BRM88_RS18840	COG4585	Histidine kinase
BRM88_RS18860	COG2894	cell division
BRM88_RS18865	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRM88_RS18875	COG0642	Histidine kinase
BRM88_RS18880	COG0745	RESPONSE REGULATOR receiver
BRM88_RS18885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRM88_RS18895	COG2194	sulfuric ester hydrolase activity
BRM88_RS18925	COG3551	Protein conserved in bacteria
BRM88_RS18990	COG0203	ribosomal protein L17
BRM88_RS19000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRM88_RS19005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRM88_RS19015	COG0201	protein transport
BRM88_RS19025	COG1841	ribosomal large subunit assembly
BRM88_RS19055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRM88_RS19065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRM88_RS19070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRM88_RS19075	COG0255	Belongs to the universal ribosomal protein uL29 family
BRM88_RS19080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRM88_RS19090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRM88_RS19105	COG0089	rRNA binding
BRM88_RS19110	COG0088	Forms part of the polypeptide exit tunnel
BRM88_RS19115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRM88_RS19120	COG0051	transcription antitermination factor activity, RNA binding
BRM88_RS19145	COG0049	tRNA binding
BRM88_RS19150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRM88_RS19155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRM88_RS19160	COG0085	RNA polymerase activity
BRM88_RS19165	COG0222	ribosome binding
BRM88_RS19170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRM88_RS19180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRM88_RS19190	COG0250	Participates in transcription elongation, termination and antitermination
BRM88_RS19195	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRM88_RS19225	COG0012	GTP binding
BRM88_RS19230	COG0193	aminoacyl-tRNA hydrolase activity
BRM88_RS19240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRM88_RS19255	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BRM88_RS19270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRM88_RS19280	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRM88_RS19300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRM88_RS19305	COG1295	ribonuclease BN
BRM88_RS19335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRM88_RS19345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRM88_RS19375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRM88_RS19400	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRM88_RS19415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM88_RS19415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRM88_RS19465	COG2890	protein-(glutamine-N5) methyltransferase activity
BRM88_RS19475	COG3634	alkyl hydroperoxide reductase activity
BRM88_RS19480	COG0583	DNA-binding transcription factor activity
BRM88_RS19490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRM88_RS19570	COG4783	chaperone-mediated protein folding
BRM88_RS19585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRM88_RS19595	COG0438	transferase activity, transferring glycosyl groups
BRM88_RS19600	COG0671	phosphoesterase, PA-phosphatase related
BRM88_RS19605	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRM88_RS19625	COG2833	Protein of unknown function (DUF455)
BRM88_RS19645	COG0285	dihydrofolate synthase activity
BRM88_RS19655	COG0406	alpha-ribazole phosphatase activity
BRM88_RS19690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRM88_RS19695	COG4208	sulfate ABC transporter
BRM88_RS19700	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRM88_RS19705	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRM88_RS19710	COG0156	8-amino-7-oxononanoate synthase activity
BRM88_RS19740	COG0604	alcohol dehydrogenase
BRM88_RS19745	COG1902	pentaerythritol trinitrate reductase activity
BRM88_RS19745	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRM88_RS19885	COG3386	PFAM SMP-30 Gluconolaconase
BRM88_RS19905	COG1024	Enoyl-CoA hydratase
BRM88_RS19915	COG0318	PFAM AMP-dependent synthetase and ligase
BRM88_RS19920	COG0583	DNA-binding transcription factor activity
BRM88_RS19960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM88_RS19965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRM88_RS19975	COG2096	Adenosyltransferase
BRM88_RS19980	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRM88_RS19995	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRM88_RS20005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRM88_RS20010	COG2967	ApaG domain
BRM88_RS20035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRM88_RS20055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRM88_RS20080	COG0642	Histidine kinase
BRM88_RS20095	COG4181	ATPase activity
BRM88_RS20105	COG2175	clavaminate synthase activity
BRM88_RS20115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BRM88_RS20155	COG0667	Aldo Keto reductase
BRM88_RS20165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRM88_RS20170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM88_RS20190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRM88_RS20205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRM88_RS20260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRM88_RS20265	COG2226	methyltransferase
BRM88_RS20320	COG0604	alcohol dehydrogenase
BRM88_RS20320	COG3321	synthase
BRM88_RS20320	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS20335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRM88_RS20350	COG0494	nUDIX hydrolase
BRM88_RS20365	COG4942	peptidase
BRM88_RS20365	COG1388	LysM domain
BRM88_RS20375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRM88_RS20390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRM88_RS20395	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRM88_RS20400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRM88_RS20420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRM88_RS20435	COG3116	cell division
BRM88_RS20440	COG0275	rRNA processing
BRM88_RS20475	COG0792	nuclease activity
BRM88_RS20480	COG1988	membrane-bound metal-dependent
BRM88_RS20485	COG0277	FAD linked oxidase domain protein
BRM88_RS20490	COG0745	RESPONSE REGULATOR receiver
BRM88_RS20495	COG2205	protein histidine kinase activity
BRM88_RS20505	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRM88_RS20510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRM88_RS20535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRM88_RS20540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRM88_RS20545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRM88_RS20565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM88_RS20565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRM88_RS20585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRM88_RS20605	COG0488	(ABC) transporter
BRM88_RS20655	COG2205	protein histidine kinase activity
BRM88_RS20695	COG2205	protein histidine kinase activity
BRM88_RS20715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRM88_RS20750	COG3039	Transposase
BRM88_RS20755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRM88_RS20770	COG3039	Transposase
BRM88_RS20780	COG3039	Transposase
BRM88_RS20835	COG3039	Transposase
BRM88_RS20885	COG0726	polysaccharide deacetylase
BRM88_RS20885	COG1649	PFAM Uncharacterised BCR, COG1649
BRM88_RS20890	COG1215	transferase activity, transferring glycosyl groups
BRM88_RS20900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRM88_RS20905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRM88_RS20910	COG1609	Transcriptional regulator
BRM88_RS20920	COG2188	Transcriptional regulator
BRM88_RS20935	COG3250	beta-galactosidase activity
BRM88_RS20990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRM88_RS20995	COG4191	Histidine kinase
BRM88_RS21000	COG0784	Response regulator, receiver
BRM88_RS21005	COG4251	negative regulation of phosphorylation
BRM88_RS21010	COG2823	Periplasmic or secreted lipoprotein
BRM88_RS21015	COG0673	inositol 2-dehydrogenase activity
BRM88_RS21020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRM88_RS21055	COG1051	belongs to the nudix hydrolase family
BRM88_RS21055	COG1056	cytidyltransferase-related domain
BRM88_RS21090	COG2921	Belongs to the UPF0250 family
BRM88_RS21105	COG1686	Belongs to the peptidase S11 family
BRM88_RS21115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRM88_RS21120	COG2951	lytic endotransglycosylase activity
BRM88_RS21135	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRM88_RS21135	COG3409	Peptidoglycan-binding domain 1 protein
BRM88_RS21135	COG1388	LysM domain
BRM88_RS21180	COG0772	Belongs to the SEDS family
BRM88_RS21195	COG1792	Involved in formation and maintenance of cell shape
BRM88_RS21200	COG1077	Cell shape determining protein MreB Mrl
BRM88_RS21205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRM88_RS21250	COG2199	diguanylate cyclase activity
BRM88_RS21255	COG0308	aminopeptidase N
BRM88_RS21285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRM88_RS21315	COG0436	Aminotransferase
BRM88_RS21330	COG1505	serine-type exopeptidase activity
BRM88_RS21355	COG0181	hydroxymethylbilane synthase activity
BRM88_RS21365	COG3275	phosphorelay sensor kinase activity
BRM88_RS21410	COG0659	secondary active sulfate transmembrane transporter activity
BRM88_RS21415	COG5297	Belongs to the glycosyl hydrolase family 6
BRM88_RS21415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRM88_RS21490	COG0598	Magnesium transport protein CorA
BRM88_RS21500	COG1113	amino acid transport
BRM88_RS21510	COG5297	Belongs to the glycosyl hydrolase family 6
BRM88_RS21515	COG4305	rare lipoprotein A
BRM88_RS21520	COG0697	spore germination
BRM88_RS21580	COG4221	oxidoreductase activity
BRM88_RS21610	COG0456	acetyltransferase
BRM88_RS21620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRM88_RS21675	COG2111	Na H antiporter
BRM88_RS21675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRM88_RS21680	COG1006	Multisubunit Na H antiporter MnhC subunit
BRM88_RS21685	COG0651	ATP synthesis coupled electron transport
BRM88_RS21695	COG2212	antiporter activity
BRM88_RS21700	COG1320	monovalent cation:proton antiporter activity
BRM88_RS21710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BRM88_RS21730	COG3104	oligopeptide transport
BRM88_RS21735	COG3483	tryptophan 2,3-dioxygenase activity
BRM88_RS21745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRM88_RS21780	COG0183	Belongs to the thiolase family
BRM88_RS21835	COG3039	Transposase
BRM88_RS21865	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRM88_RS21870	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRM88_RS21880	COG4948	Mandelate Racemase Muconate Lactonizing
BRM88_RS21920	COG0531	amino acid
BRM88_RS21960	COG4682	membrane
BRM88_RS21965	COG2133	pyrroloquinoline quinone binding
BRM88_RS22005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRM88_RS22010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRM88_RS22020	COG1610	YqeY-like protein
BRM88_RS22035	COG1295	ribonuclease BN
BRM88_RS22040	COG0358	DNA primase activity
BRM88_RS22105	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRM88_RS22120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRM88_RS22170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRM88_RS22175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRM88_RS22180	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BRM88_RS22190	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BRM88_RS22195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRM88_RS22210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRM88_RS22290	COG3039	Transposase
BRM88_RS22305	COG3328	transposase activity
BRM88_RS22320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM88_RS22320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRM88_RS22330	COG1473	amidohydrolase
BRM88_RS22335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRM88_RS22340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRM88_RS22355	COG5383	Protein conserved in bacteria
BRM88_RS22395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRM88_RS22400	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRM88_RS22415	COG0028	Belongs to the TPP enzyme family
BRM88_RS22420	COG4191	Histidine kinase
BRM88_RS22445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRM88_RS22460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRM88_RS22465	COG3177	Filamentation induced by cAMP protein fic
BRM88_RS22480	COG0596	Alpha beta hydrolase
BRM88_RS22485	COG0727	PFAM Uncharacterised protein family (UPF0153)
BRM88_RS22490	COG0318	PFAM AMP-dependent synthetase and ligase
BRM88_RS22495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRM88_RS22550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRM88_RS22560	COG0129	dihydroxy-acid dehydratase activity
BRM88_RS22585	COG3039	Transposase
BRM88_RS22595	COG0408	coproporphyrinogen oxidase activity
BRM88_RS22695	COG2353	YceI-like domain
BRM88_RS22725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRM88_RS22740	COG3386	PFAM SMP-30 Gluconolaconase
BRM88_RS22780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRM88_RS22795	COG4771	TonB-dependent receptor
BRM88_RS22805	COG0459	protein refolding
BRM88_RS22830	COG1252	NADH dehydrogenase
BRM88_RS22840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRM88_RS22845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRM88_RS22850	COG3437	response regulator, receiver
BRM88_RS22855	COG2177	Part of the ABC transporter FtsEX involved in
BRM88_RS22860	COG2884	Cell division ATP-binding protein ftsE
BRM88_RS22870	COG3118	belongs to the thioredoxin family
BRM88_RS22875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRM88_RS22890	COG0729	surface antigen
BRM88_RS22895	COG2911	Protein conserved in bacteria
BRM88_RS22930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRM88_RS22945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRM88_RS23005	COG1733	regulation of RNA biosynthetic process
BRM88_RS23010	COG0702	epimerase
BRM88_RS23045	COG0583	DNA-binding transcription factor activity
BRM88_RS23050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRM88_RS23070	COG0745	RESPONSE REGULATOR receiver
BRM88_RS23100	COG1902	pentaerythritol trinitrate reductase activity
BRM88_RS23105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRM88_RS23115	COG2814	Major facilitator Superfamily
BRM88_RS23120	COG0583	DNA-binding transcription factor activity
BRM88_RS23140	COG0084	hydrolase, TatD family'
BRM88_RS23190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRM88_RS23265	COG4770	biotin carboxylase activity
BRM88_RS23270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRM88_RS23275	COG1960	acyl-CoA dehydrogenase activity
BRM88_RS23330	COG0523	cobalamin synthesis protein
BRM88_RS23340	COG0697	spore germination
BRM88_RS23350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRM88_RS23365	COG4771	TonB-dependent receptor
BRM88_RS23370	COG0457	Tetratricopeptide repeat
BRM88_RS23385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRM88_RS23410	COG0519	Catalyzes the synthesis of GMP from XMP
BRM88_RS23410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRM88_RS23420	COG0805	protein transport
BRM88_RS23430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRM88_RS23440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRM88_RS23495	COG3661	Belongs to the glycosyl hydrolase 67 family
BRM88_RS23505	COG4948	Mandelate Racemase Muconate Lactonizing
BRM88_RS23515	COG1472	Belongs to the glycosyl hydrolase 3 family
BRM88_RS23520	COG0246	Mannitol dehydrogenase
BRM88_RS23545	COG3693	PFAM glycoside hydrolase, family 10
BRM88_RS23570	COG2211	Major facilitator Superfamily
BRM88_RS23615	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRM88_RS23665	COG1846	Transcriptional regulator
BRM88_RS23670	COG1764	response to oxidative stress
BRM88_RS23770	COG3549	Plasmid maintenance system killer
BRM88_RS23780	COG1074	ATP-dependent DNA helicase activity
BRM88_RS23785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRM88_RS23825	COG2032	superoxide dismutase activity
BRM88_RS23830	COG2032	superoxide dismutase activity
BRM88_RS23835	COG2204	response regulator
BRM88_RS23840	COG3852	Histidine kinase
BRM88_RS23845	COG0004	ammonium transporteR
BRM88_RS23850	COG0347	Belongs to the P(II) protein family
BRM88_RS23855	COG0174	glutamine synthetase
BRM88_RS23860	COG1968	undecaprenyl-diphosphatase activity
BRM88_RS23905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM88_RS23915	COG2062	phosphohistidine phosphatase, SixA
BRM88_RS23920	COG0489	protein tyrosine kinase activity
BRM88_RS23940	COG1396	sequence-specific DNA binding
BRM88_RS23945	COG3550	peptidyl-serine autophosphorylation
BRM88_RS23950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRM88_RS23955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRM88_RS23970	COG0517	IMP dehydrogenase activity
BRM88_RS23970	COG1125	glycine betaine transport
BRM88_RS23985	COG1119	ATPase activity
BRM88_RS23995	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRM88_RS24010	COG3039	Transposase
BRM88_RS24035	COG0656	L-ascorbic acid biosynthetic process
BRM88_RS24040	COG2130	NADP-dependent
BRM88_RS24045	COG0667	Aldo Keto reductase
BRM88_RS24055	COG1187	pseudouridine synthase activity
BRM88_RS24070	COG1643	Atp-dependent helicase
BRM88_RS24075	COG4807	Protein conserved in bacteria
BRM88_RS24080	COG4948	Mandelate Racemase Muconate Lactonizing
BRM88_RS24090	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRM88_RS24095	COG1028	Short-chain dehydrogenase reductase Sdr
BRM88_RS24115	COG3507	Belongs to the glycosyl hydrolase 43 family
BRM88_RS24160	COG3162	membrane
BRM88_RS24165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRM88_RS24180	COG0708	Exodeoxyribonuclease III
BRM88_RS24195	COG2091	lysine biosynthetic process via aminoadipic acid
BRM88_RS24205	COG3540	Alkaline phosphatase
BRM88_RS24235	COG2159	amidohydrolase
BRM88_RS24260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRM88_RS24265	COG0583	DNA-binding transcription factor activity
BRM88_RS24270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM88_RS24290	COG0210	DNA helicase
BRM88_RS24305	COG0531	amino acid
BRM88_RS24315	COG1322	Protein conserved in bacteria
BRM88_RS24325	COG0386	Belongs to the glutathione peroxidase family
BRM88_RS24380	COG0793	Belongs to the peptidase S41A family
BRM88_RS24385	COG4942	peptidase
BRM88_RS24395	COG2234	aminopeptidase activity
BRM88_RS24445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRM88_RS24450	COG0302	gtp cyclohydrolase
BRM88_RS24475	COG0477	Major facilitator Superfamily
BRM88_RS24485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRM88_RS24585	COG1929	Belongs to the glycerate kinase type-1 family
BRM88_RS24590	COG2271	Major facilitator Superfamily
BRM88_RS24605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRM88_RS24615	COG0861	Integral membrane protein TerC family
BRM88_RS24625	COG0584	glycerophosphoryl diester phosphodiesterase
BRM88_RS24635	COG0671	phosphoesterase, PA-phosphatase related
BRM88_RS24645	COG0726	polysaccharide deacetylase