locus-tag	class	description
TX61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TX61_RS00020	COG0187	DNA topoisomerase II activity
TX61_RS00030	COG0501	Belongs to the peptidase M48B family
TX61_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TX61_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TX61_RS00090	COG4772	TonB-dependent receptor
TX61_RS00105	COG3039	Transposase
TX61_RS00110	COG1304	FMN binding
TX61_RS00115	COG1755	Isoprenylcysteine carboxyl methyltransferase
TX61_RS00135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TX61_RS00150	COG3039	Transposase
TX61_RS00180	COG0508	dehydrogenase complex catalyzes the overall conversion of
TX61_RS00200	COG3039	Transposase
TX61_RS00210	COG0513	Belongs to the DEAD box helicase family
TX61_RS00290	COG1858	cytochrome C peroxidase
TX61_RS00295	COG0702	epimerase
TX61_RS00320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TX61_RS00340	COG1649	PFAM Uncharacterised BCR, COG1649
TX61_RS00345	COG2354	Protein conserved in bacteria
TX61_RS00350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX61_RS00360	COG3293	Transposase
TX61_RS00370	COG1511	domain protein
TX61_RS00370	COG3264	Mechanosensitive ion channel
TX61_RS00450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TX61_RS00520	COG3039	Transposase
TX61_RS00530	COG3039	Transposase
TX61_RS00560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TX61_RS00570	COG0642	Histidine kinase
TX61_RS00575	COG1090	epimerase
TX61_RS00585	COG3039	Transposase
TX61_RS00610	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS00670	COG1136	(ABC) transporter
TX61_RS00685	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS00710	COG1272	protein, Hemolysin III
TX61_RS00715	COG1205	dead DEAH box helicase
TX61_RS00715	COG1111	helicase
TX61_RS00770	COG0070	glutamate synthase
TX61_RS00770	COG0067	glutamate synthase
TX61_RS00770	COG0069	glutamate synthase activity
TX61_RS00775	COG0493	'glutamate synthase
TX61_RS00795	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS00825	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TX61_RS00830	COG1609	Transcriptional regulator
TX61_RS00855	COG0366	Alpha amylase catalytic
TX61_RS00860	COG0366	Alpha amylase catalytic
TX61_RS00865	COG2801	Transposase and inactivated derivatives
TX61_RS00880	COG3328	transposase activity
TX61_RS00910	COG0606	chelatase, subunit chli
TX61_RS00940	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TX61_RS00945	COG1166	arginine decarboxylase activity
TX61_RS00955	COG3293	Transposase
TX61_RS01025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TX61_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS01065	COG2801	Transposase and inactivated derivatives
TX61_RS01075	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TX61_RS01090	COG0210	DNA helicase
TX61_RS01100	COG3132	Protein of unknown function, DUF480
TX61_RS01110	COG0284	orotidine-5'-phosphate decarboxylase activity
TX61_RS01140	COG2937	Belongs to the GPAT DAPAT family
TX61_RS01160	COG2963	transposase activity
TX61_RS01175	COG2755	lipolytic protein G-D-S-L family
TX61_RS01185	COG3186	Phenylalanine-4-hydroxylase
TX61_RS01190	COG1522	sequence-specific DNA binding
TX61_RS01205	COG4773	Receptor
TX61_RS01210	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS01245	COG1064	alcohol dehydrogenase
TX61_RS01250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TX61_RS01255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TX61_RS01260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TX61_RS01280	COG3039	Transposase
TX61_RS01285	COG0676	glucose-6-phosphate 1-epimerase activity
TX61_RS01305	COG3135	benzoate transporter
TX61_RS01310	COG3135	benzoate transporter
TX61_RS01345	COG2963	transposase activity
TX61_RS01355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TX61_RS01365	COG3293	Transposase
TX61_RS01385	COG2853	Lipoprotein
TX61_RS01400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TX61_RS01405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TX61_RS01410	COG1127	ABC transporter
TX61_RS01440	COG3293	Transposase
TX61_RS01475	COG2801	Transposase and inactivated derivatives
TX61_RS01480	COG2963	transposase activity
TX61_RS01500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TX61_RS01505	COG3293	Transposase
TX61_RS01515	COG3265	gluconokinase activity
TX61_RS01520	COG2211	Major facilitator Superfamily
TX61_RS01525	COG3459	Glycosyltransferase 36 associated
TX61_RS01540	COG2205	protein histidine kinase activity
TX61_RS01550	COG1414	Transcriptional regulator
TX61_RS01555	COG0738	Major facilitator superfamily
TX61_RS01560	COG3254	rhamnose metabolic process
TX61_RS01585	COG0339	signal peptide processing
TX61_RS01610	COG0564	pseudouridine synthase activity
TX61_RS01620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX61_RS01635	COG1181	Belongs to the D-alanine--D-alanine ligase family
TX61_RS01665	COG3293	Transposase
TX61_RS01670	COG2963	transposase activity
TX61_RS01710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TX61_RS01720	COG0842	Transport permease protein
TX61_RS01725	COG1131	(ABC) transporter
TX61_RS01730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TX61_RS01750	COG1476	TRANSCRIPTIONal
TX61_RS01760	COG4555	ABC transporter
TX61_RS01795	COG3293	Transposase
TX61_RS01805	COG0625	glutathione transferase activity
TX61_RS01840	COG0583	DNA-binding transcription factor activity
TX61_RS01870	COG1199	ATP-dependent helicase activity
TX61_RS01890	COG1566	PFAM secretion protein HlyD family protein
TX61_RS01915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TX61_RS01945	COG3228	Belongs to the MtfA family
TX61_RS01955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TX61_RS01955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TX61_RS01960	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TX61_RS01975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TX61_RS02010	COG3237	CsbD-like
TX61_RS02015	COG0180	Tryptophanyl-tRNA synthetase
TX61_RS02020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TX61_RS02065	COG0753	catalase activity
TX61_RS02070	COG1595	DNA-templated transcription, initiation
TX61_RS02080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TX61_RS02090	COG0628	permease
TX61_RS02100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TX61_RS02105	COG1040	competence protein
TX61_RS02110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TX61_RS02115	COG0156	8-amino-7-oxononanoate synthase activity
TX61_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS02140	COG0463	Glycosyl transferase, family 2
TX61_RS02150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TX61_RS02155	COG3100	YcgL domain-containing protein
TX61_RS02175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TX61_RS02190	COG2239	Acts as a magnesium transporter
TX61_RS02200	COG1042	CoA-binding domain protein
TX61_RS02200	COG0045	succinate-CoA ligase (ADP-forming) activity
TX61_RS02200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TX61_RS02210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TX61_RS02215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TX61_RS02235	COG2963	transposase activity
TX61_RS02240	COG2801	Transposase and inactivated derivatives
TX61_RS02255	COG3485	protocatechuate 3,4-dioxygenase
TX61_RS02260	COG3485	protocatechuate 3,4-dioxygenase
TX61_RS02270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TX61_RS02275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TX61_RS02285	COG1414	Transcriptional regulator
TX61_RS02295	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS02300	COG4221	oxidoreductase activity
TX61_RS02325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TX61_RS02350	COG0463	Glycosyl transferase, family 2
TX61_RS02365	COG1475	DNA binding
TX61_RS02370	COG1192	Involved in chromosome partitioning
TX61_RS02385	COG0708	Exodeoxyribonuclease III
TX61_RS02390	COG2211	Major facilitator Superfamily
TX61_RS02405	COG0739	heme binding
TX61_RS02445	COG2963	transposase activity
TX61_RS02455	COG0745	RESPONSE REGULATOR receiver
TX61_RS02495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TX61_RS02515	COG2814	Major facilitator Superfamily
TX61_RS02530	COG1289	transmembrane transporter activity
TX61_RS02540	COG0577	efflux transmembrane transporter activity
TX61_RS02540	COG1136	(ABC) transporter
TX61_RS02545	COG0151	Belongs to the GarS family
TX61_RS02560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TX61_RS02565	COG2267	carboxylic ester hydrolase activity
TX61_RS02575	COG2267	carboxylic ester hydrolase activity
TX61_RS02580	COG0671	phosphoesterase, PA-phosphatase related
TX61_RS02580	COG2453	phosphatase
TX61_RS02590	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TX61_RS02625	COG0439	Biotin carboxylase
TX61_RS02635	COG0511	ligase activity, forming carbon-carbon bonds
TX61_RS02640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TX61_RS02655	COG1324	tolerance protein
TX61_RS02675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TX61_RS02695	COG0534	Mate efflux family protein
TX61_RS02700	COG0616	signal peptide processing
TX61_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS02725	COG0009	L-threonylcarbamoyladenylate synthase
TX61_RS02730	COG1754	DNA topoisomerase type I activity
TX61_RS02730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TX61_RS02745	COG2922	Belongs to the Smg family
TX61_RS02750	COG0758	DNA mediated transformation
TX61_RS02755	COG1652	LysM domain
TX61_RS02760	COG0242	peptide deformylase activity
TX61_RS02765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TX61_RS02770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TX61_RS02770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TX61_RS02815	COG1560	Kdo2-lipid A biosynthetic process
TX61_RS02825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX61_RS02960	COG1063	alcohol dehydrogenase
TX61_RS02975	COG1294	oxidase, subunit
TX61_RS02980	COG1271	oxidase subunit
TX61_RS02985	COG2204	response regulator
TX61_RS03020	COG2972	Histidine kinase
TX61_RS03025	COG3279	Response regulator of the LytR AlgR family
TX61_RS03030	COG3279	Response regulator of the LytR AlgR family
TX61_RS03040	COG0531	amino acid
TX61_RS03055	COG3590	peptidase
TX61_RS03070	COG0667	Aldo Keto reductase
TX61_RS03085	COG3384	dioxygenase
TX61_RS03095	COG1573	uracil-dna glycosylase
TX61_RS03100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TX61_RS03115	COG0025	NhaP-type Na H and K H
TX61_RS03120	COG1131	(ABC) transporter
TX61_RS03125	COG0842	Transport permease protein
TX61_RS03145	COG1404	Belongs to the peptidase S8 family
TX61_RS03160	COG0745	RESPONSE REGULATOR receiver
TX61_RS03210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX61_RS03235	COG2205	protein histidine kinase activity
TX61_RS03235	COG2202	Pas domain
TX61_RS03260	COG2813	Specifically methylates the guanine in position
TX61_RS03265	COG1187	pseudouridine synthase activity
TX61_RS03270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TX61_RS03305	COG0697	spore germination
TX61_RS03315	COG2011	ABC-type metal ion transport system permease component
TX61_RS03345	COG0508	dehydrogenase complex catalyzes the overall conversion of
TX61_RS03355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TX61_RS03375	COG0356	it plays a direct role in the translocation of protons across the membrane
TX61_RS03385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TX61_RS03395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TX61_RS03400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TX61_RS03405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TX61_RS03460	COG3842	ATPase activity
TX61_RS03465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TX61_RS03470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TX61_RS03485	COG3293	Transposase
TX61_RS03525	COG0339	signal peptide processing
TX61_RS03560	COG1956	GAF domain-containing protein
TX61_RS03565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TX61_RS03575	COG0720	synthase
TX61_RS03585	COG0513	Belongs to the DEAD box helicase family
TX61_RS03625	COG0626	cystathionine gamma-synthase activity
TX61_RS03660	COG3328	transposase activity
TX61_RS03685	COG2086	electron transfer activity
TX61_RS03710	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TX61_RS03710	COG0662	Cupin 2, conserved barrel domain protein
TX61_RS03715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TX61_RS03750	COG3218	ABC-type transport auxiliary lipoprotein component
TX61_RS03750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TX61_RS03755	COG1127	ABC transporter
TX61_RS03760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TX61_RS03775	COG0442	prolyl-tRNA aminoacylation
TX61_RS03785	COG1183	phosphatidylcholine synthase activity
TX61_RS03810	COG3039	Transposase
TX61_RS03850	COG2801	Transposase and inactivated derivatives
TX61_RS03855	COG2963	transposase activity
TX61_RS03880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TX61_RS03890	COG0795	lipopolysaccharide-transporting ATPase activity
TX61_RS03900	COG4974	Belongs to the 'phage' integrase family
TX61_RS03905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TX61_RS03910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TX61_RS03910	COG0047	phosphoribosylformylglycinamidine synthase activity
TX61_RS03915	COG5295	Hep Hag repeat protein
TX61_RS03935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TX61_RS03945	COG1459	type II secretion system
TX61_RS03950	COG2165	general secretion pathway protein
TX61_RS03955	COG4970	Tfp pilus assembly protein FimT
TX61_RS03960	COG2165	general secretion pathway protein
TX61_RS03965	COG4795	General secretion pathway protein
TX61_RS03970	COG3156	type II secretion system protein K
TX61_RS03975	COG3166	PFAM Fimbrial assembly family protein
TX61_RS03990	COG1450	Type ii and iii secretion system protein
TX61_RS04000	COG2188	Transcriptional regulator
TX61_RS04035	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TX61_RS04040	COG1518	maintenance of DNA repeat elements
TX61_RS04080	COG1399	metal-binding, possibly nucleic acid-binding protein
TX61_RS04105	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS04110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TX61_RS04120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TX61_RS04125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TX61_RS04165	COG3829	transcription factor binding
TX61_RS04190	COG3039	Transposase
TX61_RS04230	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS04240	COG0678	peroxiredoxin activity
TX61_RS04260	COG0330	HflC and HflK could
TX61_RS04265	COG0330	HflC and HflK could
TX61_RS04280	COG0308	aminopeptidase N
TX61_RS04325	COG1560	Kdo2-lipid A biosynthetic process
TX61_RS04330	COG1519	Transferase
TX61_RS04335	COG1538	Outer membrane efflux protein
TX61_RS04340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TX61_RS04370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TX61_RS04375	COG0066	3-isopropylmalate dehydratase activity
TX61_RS04410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TX61_RS04415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TX61_RS04420	COG3710	Transcriptional regulator
TX61_RS04440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TX61_RS04480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TX61_RS04490	COG3781	membrane
TX61_RS04505	COG0625	glutathione transferase activity
TX61_RS04515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TX61_RS04520	COG1217	gtp-binding protein TYPA
TX61_RS04540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TX61_RS04560	COG2963	transposase activity
TX61_RS04565	COG2801	Transposase and inactivated derivatives
TX61_RS04610	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS04635	COG2963	transposase activity
TX61_RS04675	COG3293	Transposase
TX61_RS04695	COG3039	Transposase
TX61_RS04715	COG3293	Transposase
TX61_RS04720	COG0584	glycerophosphoryl diester phosphodiesterase
TX61_RS04745	COG0473	3-isopropylmalate dehydrogenase activity
TX61_RS04775	COG2963	transposase activity
TX61_RS04840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TX61_RS04865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TX61_RS04870	COG0631	protein serine/threonine phosphatase activity
TX61_RS04940	COG0582	viral genome integration into host DNA
TX61_RS04950	COG0859	PFAM glycosyl transferase family 9
TX61_RS04955	COG3642	lipopolysaccharide core region biosynthetic process
TX61_RS04960	COG1234	tRNA 3'-trailer cleavage
TX61_RS04965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TX61_RS04975	COG0315	cyclic pyranopterin monophosphate synthase activity
TX61_RS04980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TX61_RS04985	COG0314	molybdopterin synthase activity
TX61_RS05010	COG0537	adenosine 5'-monophosphoramidase activity
TX61_RS05030	COG0714	Associated with various cellular activities
TX61_RS05050	COG0242	peptide deformylase activity
TX61_RS05085	COG3039	Transposase
TX61_RS05105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TX61_RS05110	COG0726	polysaccharide deacetylase
TX61_RS05155	COG2211	Major facilitator Superfamily
TX61_RS05160	COG1609	Transcriptional regulator
TX61_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS05170	COG2851	Citrate transporter
TX61_RS05185	COG0642	Histidine kinase
TX61_RS05195	COG2197	response regulator
TX61_RS05220	COG0583	DNA-binding transcription factor activity
TX61_RS05235	COG4191	Histidine kinase
TX61_RS05250	COG0281	malic enzyme
TX61_RS05250	COG0280	phosphate acetyltransferase
TX61_RS05260	COG2963	transposase activity
TX61_RS05265	COG2801	Transposase and inactivated derivatives
TX61_RS05290	COG0352	thiamine-phosphate diphosphorylase activity
TX61_RS05295	COG1773	rubredoxin
TX61_RS05300	COG2912	Transglutaminase-like superfamily
TX61_RS05320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TX61_RS05340	COG0006	proline dipeptidase activity
TX61_RS05355	COG3293	Transposase
TX61_RS05375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TX61_RS05390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TX61_RS05395	COG1561	YicC-like family, N-terminal region
TX61_RS05415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TX61_RS05425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TX61_RS05450	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TX61_RS05500	COG0714	Associated with various cellular activities
TX61_RS05520	COG2304	oxidoreductase activity
TX61_RS05535	COG1301	dicarboxylic acid transport
TX61_RS05540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TX61_RS05545	COG4773	Receptor
TX61_RS05550	COG0739	heme binding
TX61_RS05555	COG1376	ErfK ybiS ycfS ynhG family protein
TX61_RS05580	COG1022	Amp-dependent synthetase and ligase
TX61_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS05605	COG0642	Histidine kinase
TX61_RS05625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TX61_RS05630	COG4149	molybdate abc transporter
TX61_RS05635	COG0725	ABC transporter, periplasmic molybdate-binding protein
TX61_RS05640	COG3453	Protein conserved in bacteria
TX61_RS05640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TX61_RS05675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TX61_RS05680	COG3293	Transposase
TX61_RS05695	COG2205	protein histidine kinase activity
TX61_RS05700	COG0745	RESPONSE REGULATOR receiver
TX61_RS05750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX61_RS05755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TX61_RS05790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TX61_RS05825	COG2801	Transposase and inactivated derivatives
TX61_RS05865	COG2201	protein-glutamate methylesterase activity
TX61_RS05915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TX61_RS05930	COG1842	Phage shock protein A
TX61_RS05955	COG0754	glutathionylspermidine amidase activity
TX61_RS06030	COG0531	amino acid
TX61_RS06035	COG2197	response regulator
TX61_RS06045	COG1113	amino acid transport
TX61_RS06055	COG1271	oxidase subunit
TX61_RS06060	COG1294	oxidase, subunit
TX61_RS06070	COG2239	Acts as a magnesium transporter
TX61_RS06075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TX61_RS06080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TX61_RS06090	COG1660	Displays ATPase and GTPase activities
TX61_RS06095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TX61_RS06100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TX61_RS06115	COG1137	ATPase activity
TX61_RS06120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TX61_RS06130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TX61_RS06140	COG0271	Belongs to the BolA IbaG family
TX61_RS06145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TX61_RS06165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TX61_RS06180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TX61_RS06190	COG0628	permease
TX61_RS06200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TX61_RS06205	COG3178	'Phosphotransferase
TX61_RS06225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TX61_RS06230	COG1555	photosystem II stabilization
TX61_RS06280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TX61_RS06290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TX61_RS06310	COG0228	four-way junction DNA binding
TX61_RS06315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TX61_RS06320	COG0336	Belongs to the RNA methyltransferase TrmD family
TX61_RS06330	COG0534	Mate efflux family protein
TX61_RS06360	COG0542	response to heat
TX61_RS06375	COG2963	transposase activity
TX61_RS06390	COG4206	TonB-dependent receptor
TX61_RS06440	COG0019	diaminopimelate decarboxylase activity
TX61_RS06450	COG2814	Major facilitator Superfamily
TX61_RS06455	COG4264	IucA IucC family
TX61_RS06465	COG4772	TonB-dependent receptor
TX61_RS06475	COG2801	Transposase and inactivated derivatives
TX61_RS06480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TX61_RS06480	COG4651	solute:proton antiporter activity
TX61_RS06510	COG0488	(ABC) transporter
TX61_RS06530	COG0657	acetylesterase activity
TX61_RS06530	COG2755	lipolytic protein G-D-S-L family
TX61_RS06555	COG2207	Transcriptional regulator
TX61_RS06560	COG0326	Molecular chaperone. Has ATPase activity
TX61_RS06580	COG2963	transposase activity
TX61_RS06590	COG3328	transposase activity
TX61_RS06620	COG2801	Transposase and inactivated derivatives
TX61_RS06625	COG2963	transposase activity
TX61_RS06630	COG3039	Transposase
TX61_RS06635	COG2146	nitrite reductase [NAD(P)H] activity
TX61_RS06645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TX61_RS06650	COG0719	Fe-S assembly protein
TX61_RS06655	COG0396	ATPase activity
TX61_RS06660	COG0719	Fe-S assembly protein
TX61_RS06665	COG1959	2 iron, 2 sulfur cluster binding
TX61_RS06680	COG0693	protein deglycase activity
TX61_RS06710	COG3039	Transposase
TX61_RS06725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TX61_RS06750	COG0519	Catalyzes the synthesis of GMP from XMP
TX61_RS06765	COG1678	Uncharacterized ACR, COG1678
TX61_RS06770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TX61_RS06780	COG1764	response to oxidative stress
TX61_RS06790	COG0384	phenazine biosynthesis protein PhzF
TX61_RS06795	COG0384	phenazine biosynthesis protein PhzF
TX61_RS06805	COG0527	aspartate kinase activity
TX61_RS06835	COG0142	geranyltranstransferase activity
TX61_RS06840	COG0629	single-stranded DNA binding
TX61_RS06845	COG4251	negative regulation of phosphorylation
TX61_RS06845	COG5001	Diguanylate cyclase
TX61_RS06845	COG2203	Gaf domain
TX61_RS06845	COG3706	GGDEF domain
TX61_RS06850	COG0604	alcohol dehydrogenase
TX61_RS06850	COG3321	synthase
TX61_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS06865	COG3293	Transposase
TX61_RS06885	COG2879	small protein
TX61_RS06890	COG1966	Carbon starvation protein
TX61_RS06895	COG1741	Belongs to the pirin family
TX61_RS06920	COG3039	Transposase
TX61_RS06955	COG3293	Transposase
TX61_RS07005	COG1741	Belongs to the pirin family
TX61_RS07030	COG3590	peptidase
TX61_RS07045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TX61_RS07050	COG2202	Pas domain
TX61_RS07050	COG2200	EAL domain
TX61_RS07050	COG2199	diguanylate cyclase activity
TX61_RS07055	COG0835	chemotaxis
TX61_RS07060	COG0840	transmembrane signaling receptor activity
TX61_RS07065	COG2198	Histidine kinase
TX61_RS07065	COG0643	Histidine kinase
TX61_RS07075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TX61_RS07085	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TX61_RS07100	COG2205	protein histidine kinase activity
TX61_RS07125	COG3039	Transposase
TX61_RS07145	COG3039	Transposase
TX61_RS07180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TX61_RS07185	COG0735	belongs to the Fur family
TX61_RS07225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TX61_RS07230	COG0084	hydrolase, TatD family'
TX61_RS07245	COG1960	acyl-CoA dehydrogenase activity
TX61_RS07270	COG0367	asparagine synthase
TX61_RS07280	COG0305	Participates in initiation and elongation during chromosome replication
TX61_RS07285	COG0415	Belongs to the DNA photolyase family
TX61_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS07350	COG3039	Transposase
TX61_RS07410	COG5002	protein histidine kinase activity
TX61_RS07410	COG5001	Diguanylate cyclase
TX61_RS07415	COG1187	pseudouridine synthase activity
TX61_RS07430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TX61_RS07440	COG0475	glutathione-regulated potassium exporter activity
TX61_RS07445	COG5002	protein histidine kinase activity
TX61_RS07445	COG5000	phosphorelay sensor kinase activity
TX61_RS07450	COG0745	RESPONSE REGULATOR receiver
TX61_RS07480	COG1132	(ABC) transporter
TX61_RS07490	COG3293	Transposase
TX61_RS07500	COG3039	Transposase
TX61_RS07510	COG3039	Transposase
TX61_RS07515	COG3209	COG3209 Rhs family protein
TX61_RS07520	COG3039	Transposase
TX61_RS07545	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TX61_RS07555	COG4969	Belongs to the N-Me-Phe pilin family
TX61_RS07560	COG2194	sulfuric ester hydrolase activity
TX61_RS07580	COG2184	nucleotidyltransferase activity
TX61_RS07600	COG0045	succinate-CoA ligase (ADP-forming) activity
TX61_RS07605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TX61_RS07615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TX61_RS07615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TX61_RS07620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TX61_RS07625	COG0564	pseudouridine synthase activity
TX61_RS07650	COG3387	PFAM Glycoside hydrolase 15-related
TX61_RS07655	COG1877	trehalose-phosphatase activity
TX61_RS07695	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TX61_RS07715	COG1595	DNA-templated transcription, initiation
TX61_RS07725	COG1946	Acyl-CoA thioesterase
TX61_RS07740	COG0824	Thioesterase
TX61_RS07745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TX61_RS07755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TX61_RS07760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TX61_RS07765	COG0268	Binds directly to 16S ribosomal RNA
TX61_RS07770	COG0728	peptidoglycan biosynthetic process
TX61_RS07775	COG0196	riboflavin kinase activity
TX61_RS07785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TX61_RS07790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TX61_RS07805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TX61_RS07810	COG1845	cytochrome c oxidase, subunit III
TX61_RS07815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TX61_RS07835	COG3209	COG3209 Rhs family protein
TX61_RS07835	COG3209	COG3209 Rhs family protein
TX61_RS07850	COG2963	transposase activity
TX61_RS07880	COG2801	Transposase and inactivated derivatives
TX61_RS07885	COG2963	transposase activity
TX61_RS07900	COG2963	transposase activity
TX61_RS07965	COG0632	four-way junction helicase activity
TX61_RS07975	COG2255	four-way junction helicase activity
TX61_RS07980	COG0824	Thioesterase
TX61_RS07990	COG0848	biopolymer transport protein
TX61_RS08005	COG2885	chlorophyll binding
TX61_RS08015	COG0602	queuosine metabolic process
TX61_RS08020	COG1187	pseudouridine synthase activity
TX61_RS08065	COG3293	Transposase
TX61_RS08075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TX61_RS08240	COG3179	chitinase
TX61_RS08285	COG4695	Portal protein
TX61_RS08320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TX61_RS08335	COG0514	ATP-dependent DNA helicase (RecQ)
TX61_RS08340	COG0783	Belongs to the Dps family
TX61_RS08345	COG1643	Atp-dependent helicase
TX61_RS08365	COG0837	glucose binding
TX61_RS08375	COG3293	Transposase
TX61_RS08410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TX61_RS08420	COG1215	transferase activity, transferring glycosyl groups
TX61_RS08425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TX61_RS08435	COG1199	ATP-dependent helicase activity
TX61_RS08445	COG1397	ADP-ribosylglycohydrolase
TX61_RS08455	COG0189	ligase activity
TX61_RS08470	COG0835	chemotaxis
TX61_RS08475	COG0840	transmembrane signaling receptor activity
TX61_RS08480	COG0643	Histidine kinase
TX61_RS08480	COG2198	Histidine kinase
TX61_RS08480	COG0784	Response regulator, receiver
TX61_RS08510	COG2304	oxidoreductase activity
TX61_RS08525	COG1446	asparaginase
TX61_RS08530	COG3142	Participates in the control of copper homeostasis
TX61_RS08580	COG3537	Alpha-1,2-mannosidase
TX61_RS08640	COG1472	Belongs to the glycosyl hydrolase 3 family
TX61_RS08650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TX61_RS08655	COG3858	chitin binding
TX61_RS08655	COG1388	LysM domain
TX61_RS08670	COG0837	glucose binding
TX61_RS08675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TX61_RS08685	COG0494	nUDIX hydrolase
TX61_RS08695	COG3956	TIGRFAM MazG family protein
TX61_RS08705	COG0330	HflC and HflK could
TX61_RS08720	COG0509	glycine decarboxylation via glycine cleavage system
TX61_RS08745	COG1960	acyl-CoA dehydrogenase activity
TX61_RS08755	COG1309	transcriptional regulator
TX61_RS08760	COG4771	TonB-dependent receptor
TX61_RS08770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TX61_RS08780	COG0463	Glycosyl transferase, family 2
TX61_RS08785	COG0517	IMP dehydrogenase activity
TX61_RS08785	COG0516	GMP reductase activity
TX61_RS08795	COG1272	protein, Hemolysin III
TX61_RS08805	COG0739	heme binding
TX61_RS08810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TX61_RS08815	COG0626	cystathionine gamma-synthase activity
TX61_RS08825	COG1760	l-serine dehydratase
TX61_RS08835	COG2353	YceI-like domain
TX61_RS08845	COG2353	YceI-like domain
TX61_RS08895	COG3867	Arabinogalactan endo-beta-1,4-galactanase
TX61_RS08920	COG1960	acyl-CoA dehydrogenase activity
TX61_RS08925	COG1024	Enoyl-CoA hydratase
TX61_RS08945	COG1250	3-hydroxyacyl-CoA dehydrogenase
TX61_RS08945	COG1024	Enoyl-CoA hydratase
TX61_RS08960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TX61_RS08990	COG1381	Involved in DNA repair and RecF pathway recombination
TX61_RS09005	COG2954	triphosphatase activity
TX61_RS09020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TX61_RS09025	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TX61_RS09030	COG3046	protein related to deoxyribodipyrimidine photolyase
TX61_RS09040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TX61_RS09045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TX61_RS09050	COG1278	Cold shock
TX61_RS09075	COG1201	RNA secondary structure unwinding
TX61_RS09080	COG1793	dna ligase
TX61_RS09090	COG1793	dna ligase
TX61_RS09090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TX61_RS09120	COG0183	Belongs to the thiolase family
TX61_RS09135	COG1451	nucleotide metabolic process
TX61_RS09150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TX61_RS09185	COG1047	Peptidyl-prolyl cis-trans
TX61_RS09200	COG2824	Alkylphosphonate utilization operon protein PhnA
TX61_RS09215	COG1902	pentaerythritol trinitrate reductase activity
TX61_RS09220	COG2814	Major facilitator Superfamily
TX61_RS09265	COG3293	Transposase
TX61_RS09270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TX61_RS09270	COG0392	lysyltransferase activity
TX61_RS09280	COG0251	oxidation-reduction process
TX61_RS09285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TX61_RS09300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TX61_RS09325	COG1595	DNA-templated transcription, initiation
TX61_RS09345	COG2878	Part of a membrane complex involved in electron transport
TX61_RS09355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TX61_RS09355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TX61_RS09365	COG0346	lactoylglutathione lyase activity
TX61_RS09375	COG0833	amino acid
TX61_RS09380	COG2040	homocysteine
TX61_RS09390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TX61_RS09420	COG0529	Catalyzes the synthesis of activated sulfate
TX61_RS09420	COG2895	sulfate adenylyltransferase (ATP) activity
TX61_RS09455	COG1981	membrane
TX61_RS09480	COG1131	(ABC) transporter
TX61_RS09485	COG4771	TonB-dependent receptor
TX61_RS09495	COG0825	malonyl-CoA metabolic process
TX61_RS09515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX61_RS09520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TX61_RS09535	COG0750	zinc metalloprotease
TX61_RS09545	COG0575	Belongs to the CDS family
TX61_RS09555	COG0233	cytoplasmic translational termination
TX61_RS09570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TX61_RS09630	COG1393	Belongs to the ArsC family
TX61_RS09645	COG0367	asparagine synthase
TX61_RS09660	COG4774	siderophore transport
TX61_RS09695	COG1566	PFAM secretion protein HlyD family protein
TX61_RS09700	COG2814	Major facilitator Superfamily
TX61_RS09735	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS09755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TX61_RS09765	COG1960	acyl-CoA dehydrogenase activity
TX61_RS09795	COG2914	Belongs to the UPF0125 (RnfH) family
TX61_RS09800	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TX61_RS09810	COG0497	DNA recombination
TX61_RS09820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TX61_RS09825	COG0443	Heat shock 70 kDa protein
TX61_RS09830	COG0484	heat shock protein binding
TX61_RS09835	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TX61_RS09840	COG1605	Chorismate mutase
TX61_RS09840	COG0287	Prephenate dehydrogenase
TX61_RS09855	COG0583	DNA-binding transcription factor activity
TX61_RS09860	COG1132	(ABC) transporter
TX61_RS09895	COG2850	peptidyl-arginine hydroxylation
TX61_RS09920	COG1253	flavin adenine dinucleotide binding
TX61_RS09930	COG3293	Transposase
TX61_RS09940	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS09980	COG1131	(ABC) transporter
TX61_RS09985	COG1725	Transcriptional regulator
TX61_RS09995	COG0386	Belongs to the glutathione peroxidase family
TX61_RS10010	COG2900	Belongs to the SlyX family
TX61_RS10025	COG1609	Transcriptional regulator
TX61_RS10035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TX61_RS10045	COG0646	methionine synthase
TX61_RS10045	COG1410	methionine synthase
TX61_RS10050	COG1410	methionine synthase
TX61_RS10050	COG0646	methionine synthase
TX61_RS10055	COG2226	methyltransferase
TX61_RS10060	COG1960	acyl-CoA dehydrogenase activity
TX61_RS10080	COG0557	exoribonuclease II activity
TX61_RS10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX61_RS10110	COG3039	Transposase
TX61_RS10130	COG3039	Transposase
TX61_RS10165	COG3328	transposase activity
TX61_RS10175	COG1278	Cold shock
TX61_RS10190	COG3039	Transposase
TX61_RS10205	COG2801	Transposase and inactivated derivatives
TX61_RS10210	COG2963	transposase activity
TX61_RS10245	COG3039	Transposase
TX61_RS10255	COG0583	DNA-binding transcription factor activity
TX61_RS10305	COG2201	protein-glutamate methylesterase activity
TX61_RS10330	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TX61_RS10340	COG0531	amino acid
TX61_RS10345	COG0531	amino acid
TX61_RS10360	COG0277	FAD linked oxidase domain protein
TX61_RS10425	COG0436	Aminotransferase
TX61_RS10450	COG1187	pseudouridine synthase activity
TX61_RS10455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TX61_RS10465	COG2350	Protein conserved in bacteria
TX61_RS10495	COG1175	transmembrane transport
TX61_RS10500	COG0395	ABC-type sugar transport system, permease component
TX61_RS10525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TX61_RS10530	COG2957	Belongs to the agmatine deiminase family
TX61_RS10545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TX61_RS10550	COG0539	negative regulation of cytoplasmic translation
TX61_RS10555	COG0776	regulation of translation
TX61_RS10565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TX61_RS10570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TX61_RS10580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TX61_RS10585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TX61_RS10585	COG0475	glutathione-regulated potassium exporter activity
TX61_RS10620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TX61_RS10635	COG3002	Belongs to the UPF0753 family
TX61_RS10640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TX61_RS10645	COG0583	DNA-binding transcription factor activity
TX61_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS10665	COG0583	DNA-binding transcription factor activity
TX61_RS10685	COG1914	H( )-stimulated, divalent metal cation uptake system
TX61_RS10705	COG0668	transmembrane transport
TX61_RS10730	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS10735	COG1183	phosphatidylcholine synthase activity
TX61_RS10745	COG3243	poly(R)-hydroxyalkanoic acid synthase
TX61_RS10760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX61_RS10760	COG0723	plastoquinol--plastocyanin reductase activity
TX61_RS10770	COG2183	response to ionizing radiation
TX61_RS10780	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TX61_RS10795	COG0671	phosphoesterase, PA-phosphatase related
TX61_RS10810	COG1794	racemase activity, acting on amino acids and derivatives
TX61_RS10815	COG0697	spore germination
TX61_RS10840	COG1012	belongs to the aldehyde dehydrogenase family
TX61_RS10875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TX61_RS10885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX61_RS10905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TX61_RS10920	COG0131	Imidazoleglycerol-phosphate dehydratase
TX61_RS10920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TX61_RS10930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TX61_RS10940	COG0140	phosphoribosyl-ATP diphosphatase activity
TX61_RS10940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TX61_RS11085	COG3293	Transposase
TX61_RS11105	COG3293	Transposase
TX61_RS11140	COG2801	Transposase and inactivated derivatives
TX61_RS11160	COG3039	Transposase
TX61_RS11175	COG3328	transposase activity
TX61_RS11210	COG0322	excinuclease ABC activity
TX61_RS11220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TX61_RS11230	COG1663	tetraacyldisaccharide 4'-kinase activity
TX61_RS11245	COG0811	peptide transport
TX61_RS11270	COG4591	ABC-type transport system involved in lipoprotein release permease component
TX61_RS11285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TX61_RS11300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TX61_RS11310	COG0354	folic acid binding
TX61_RS11320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TX61_RS11330	COG0363	glucosamine-6-phosphate deaminase activity
TX61_RS11335	COG0129	dihydroxy-acid dehydratase activity
TX61_RS11340	COG0800	Aldolase
TX61_RS11375	COG0784	Response regulator, receiver
TX61_RS11375	COG2205	protein histidine kinase activity
TX61_RS11375	COG5002	protein histidine kinase activity
TX61_RS11385	COG3293	Transposase
TX61_RS11470	COG0386	Belongs to the glutathione peroxidase family
TX61_RS11555	COG2203	Gaf domain
TX61_RS11555	COG3706	GGDEF domain
TX61_RS11555	COG4251	negative regulation of phosphorylation
TX61_RS11555	COG5001	Diguanylate cyclase
TX61_RS11565	COG1472	Belongs to the glycosyl hydrolase 3 family
TX61_RS11610	COG0617	tRNA 3'-terminal CCA addition
TX61_RS11620	COG1469	GTP cyclohydrolase I activity
TX61_RS11625	COG0860	N-Acetylmuramoyl-L-alanine amidase
TX61_RS11675	COG4566	intracellular signal transduction
TX61_RS11695	COG2963	transposase activity
TX61_RS11705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TX61_RS11710	COG0077	Prephenate dehydratase
TX61_RS11710	COG1605	Chorismate mutase
TX61_RS11720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TX61_RS11765	COG1228	amidohydrolase
TX61_RS11770	COG2986	histidine ammonia-lyase
TX61_RS11780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TX61_RS11800	COG2963	transposase activity
TX61_RS11810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TX61_RS11820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TX61_RS11835	COG3115	cell septum assembly
TX61_RS11845	COG0359	binds to the 23S rRNA
TX61_RS11855	COG0360	Binds together with S18 to 16S ribosomal RNA
TX61_RS11860	COG0316	Belongs to the HesB IscA family
TX61_RS11895	COG0288	reversible hydration of carbon dioxide
TX61_RS11920	COG2925	Exonuclease
TX61_RS11930	COG0667	Aldo Keto reductase
TX61_RS11950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TX61_RS11950	COG0116	Belongs to the methyltransferase superfamily
TX61_RS11960	COG0488	(ABC) transporter
TX61_RS11965	COG4133	protoheme IX ABC transporter activity
TX61_RS11970	COG0488	(ABC) transporter
TX61_RS12005	COG0494	nUDIX hydrolase
TX61_RS12015	COG1024	Enoyl-CoA hydratase
TX61_RS12025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TX61_RS12040	COG3039	Transposase
TX61_RS12055	COG3293	Transposase
TX61_RS12075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TX61_RS12080	COG0573	inorganic phosphate transmembrane transporter activity
TX61_RS12095	COG0704	Plays a role in the regulation of phosphate uptake
TX61_RS12105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TX61_RS12120	COG3328	transposase activity
TX61_RS12150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TX61_RS12155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TX61_RS12160	COG1862	Preprotein translocase
TX61_RS12165	COG0343	queuine tRNA-ribosyltransferase activity
TX61_RS12235	COG3293	Transposase
TX61_RS12250	COG0405	Gamma-glutamyltransferase
TX61_RS12255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TX61_RS12270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TX61_RS12275	COG0742	ribosomal rna small subunit methyltransferase
TX61_RS12300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TX61_RS12335	COG3039	Transposase
TX61_RS12340	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS12345	COG3039	Transposase
TX61_RS12375	COG0303	'Molybdopterin
TX61_RS12385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TX61_RS12395	COG1426	Protein conserved in bacteria
TX61_RS12405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TX61_RS12420	COG1024	Enoyl-CoA hydratase
TX61_RS12420	COG1250	3-hydroxyacyl-CoA dehydrogenase
TX61_RS12425	COG0183	Belongs to the thiolase family
TX61_RS12430	COG0038	chloride channel
TX61_RS12450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TX61_RS12470	COG1674	ftsk spoiiie
TX61_RS12475	COG0492	ferredoxin-NADP+ reductase activity
TX61_RS12505	COG0542	response to heat
TX61_RS12545	COG5001	Diguanylate cyclase
TX61_RS12550	COG4585	Histidine kinase
TX61_RS12560	COG5002	protein histidine kinase activity
TX61_RS12580	COG0835	chemotaxis
TX61_RS12580	COG0784	Response regulator, receiver
TX61_RS12590	COG1558	bacterial-type flagellum-dependent cell motility
TX61_RS12595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TX61_RS12605	COG4787	bacterial-type flagellum-dependent cell motility
TX61_RS12640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TX61_RS12645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TX61_RS12675	COG2201	protein-glutamate methylesterase activity
TX61_RS12695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TX61_RS12705	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS12735	COG1677	Flagellar hook-basal body complex protein FliE
TX61_RS12785	COG3190	flagellar
TX61_RS12800	COG1684	flagellar biosynthetic protein fliR
TX61_RS12855	COG2198	Histidine kinase
TX61_RS12855	COG0643	Histidine kinase
TX61_RS12855	COG0784	Response regulator, receiver
TX61_RS12870	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS12885	COG3039	Transposase
TX61_RS12890	COG3209	COG3209 Rhs family protein
TX61_RS12900	COG3039	Transposase
TX61_RS12995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TX61_RS13000	COG4988	ABC transporter
TX61_RS13020	COG1271	oxidase subunit
TX61_RS13030	COG1294	oxidase, subunit
TX61_RS13055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TX61_RS13075	COG0165	Argininosuccinate lyase
TX61_RS13090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TX61_RS13095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TX61_RS13105	COG0137	argininosuccinate synthase activity
TX61_RS13110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TX61_RS13125	COG2166	iron-sulfur cluster assembly
TX61_RS13155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TX61_RS13165	COG4302	ethanolamine ammonia-lyase activity
TX61_RS13170	COG3293	Transposase
TX61_RS13205	COG3039	Transposase
TX61_RS13215	COG4677	pectinesterase activity
TX61_RS13250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TX61_RS13255	COG0402	S-adenosylhomocysteine deaminase activity
TX61_RS13270	COG1509	lysine 2,3-aminomutase activity
TX61_RS13275	COG5001	Diguanylate cyclase
TX61_RS13275	COG3300	MHYT domain
TX61_RS13290	COG0483	inositol monophosphate 1-phosphatase activity
TX61_RS13295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TX61_RS13315	COG0488	(ABC) transporter
TX61_RS13320	COG0513	Belongs to the DEAD box helicase family
TX61_RS13340	COG0625	glutathione transferase activity
TX61_RS13350	COG1671	Belongs to the UPF0178 family
TX61_RS13355	COG4681	YaeQ
TX61_RS13360	COG2081	HI0933 family
TX61_RS13380	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS13400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TX61_RS13405	COG0860	N-Acetylmuramoyl-L-alanine amidase
TX61_RS13410	COG0802	atpase or kinase
TX61_RS13415	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TX61_RS13415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TX61_RS13420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TX61_RS13440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TX61_RS13490	COG3328	transposase activity
TX61_RS13520	COG2969	positive regulation of protein catabolic process
TX61_RS13525	COG0625	glutathione transferase activity
TX61_RS13530	COG2857	Cytochrome c1
TX61_RS13535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TX61_RS13540	COG0723	plastoquinol--plastocyanin reductase activity
TX61_RS13545	COG0741	lytic transglycosylase activity
TX61_RS13570	COG1702	phosphate starvation-inducible protein PhoH
TX61_RS13590	COG4535	Mg2 and Co2 transporter CorC
TX61_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
TX61_RS13615	COG1177	transmembrane transport
TX61_RS13620	COG1176	ABC-type spermidine putrescine transport system, permease component I
TX61_RS13625	COG3842	ATPase activity
TX61_RS13660	COG0174	glutamine synthetase
TX61_RS13665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX61_RS13675	COG0477	Major facilitator Superfamily
TX61_RS13685	COG0243	molybdopterin cofactor binding
TX61_RS13695	COG2223	nitrite transmembrane transporter activity
TX61_RS13700	COG3293	Transposase
TX61_RS13710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TX61_RS13715	COG1121	(ABC) transporter
TX61_RS13725	COG2733	membrane
TX61_RS13730	COG0784	Response regulator, receiver
TX61_RS13730	COG5002	protein histidine kinase activity
TX61_RS13730	COG2205	protein histidine kinase activity
TX61_RS13740	COG3039	Transposase
TX61_RS13745	COG2902	Dehydrogenase
TX61_RS13755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TX61_RS13760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TX61_RS13780	COG1609	Transcriptional regulator
TX61_RS13785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TX61_RS13785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TX61_RS13790	COG1105	Belongs to the carbohydrate kinase PfkB family
TX61_RS13795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TX61_RS13795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TX61_RS13805	COG3039	Transposase
TX61_RS13810	COG3039	Transposase
TX61_RS13885	COG3039	Transposase
TX61_RS13935	COG3039	Transposase
TX61_RS13965	COG4771	TonB-dependent receptor
TX61_RS13975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TX61_RS13995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TX61_RS14000	COG1360	Flagellar Motor Protein
TX61_RS14010	COG0835	chemotaxis
TX61_RS14020	COG0745	RESPONSE REGULATOR receiver
TX61_RS14050	COG0840	transmembrane signaling receptor activity
TX61_RS14060	COG0840	transmembrane signaling receptor activity
TX61_RS14065	COG0840	transmembrane signaling receptor activity
TX61_RS14070	COG0840	transmembrane signaling receptor activity
TX61_RS14075	COG0840	transmembrane signaling receptor activity
TX61_RS14080	COG0840	transmembrane signaling receptor activity
TX61_RS14090	COG0835	chemotaxis
TX61_RS14115	COG0840	transmembrane signaling receptor activity
TX61_RS14140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TX61_RS14170	COG0318	PFAM AMP-dependent synthetase and ligase
TX61_RS14175	COG1024	Enoyl-CoA hydratase
TX61_RS14180	COG2205	protein histidine kinase activity
TX61_RS14180	COG2198	Histidine kinase
TX61_RS14180	COG0784	Response regulator, receiver
TX61_RS14200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TX61_RS14240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TX61_RS14250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TX61_RS14255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TX61_RS14265	COG0505	Belongs to the CarA family
TX61_RS14270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TX61_RS14280	COG3293	Transposase
TX61_RS14285	COG2258	MOSC domain
TX61_RS14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TX61_RS14340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TX61_RS14355	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS14365	COG0477	Major facilitator Superfamily
TX61_RS14375	COG1070	Carbohydrate kinase
TX61_RS14390	COG1501	Belongs to the glycosyl hydrolase 31 family
TX61_RS14405	COG0800	Aldolase
TX61_RS14410	COG4948	Mandelate Racemase Muconate Lactonizing
TX61_RS14420	COG3734	2-keto-3-deoxy-galactonokinase
TX61_RS14425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TX61_RS14435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TX61_RS14450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TX61_RS14455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TX61_RS14465	COG0351	phosphomethylpyrimidine kinase
TX61_RS14495	COG0583	DNA-binding transcription factor activity
TX61_RS14500	COG1741	Belongs to the pirin family
TX61_RS14520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TX61_RS14525	COG0305	Participates in initiation and elongation during chromosome replication
TX61_RS14545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TX61_RS14550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TX61_RS14560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TX61_RS14575	COG1546	Belongs to the CinA family
TX61_RS14580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TX61_RS14595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TX61_RS14605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TX61_RS14610	COG1534	Rna-binding protein
TX61_RS14625	COG1238	metal cluster binding
TX61_RS14630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TX61_RS14635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TX61_RS14640	COG2840	Smr protein MutS2
TX61_RS14650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TX61_RS14660	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TX61_RS14665	COG0148	phosphopyruvate hydratase activity
TX61_RS14675	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TX61_RS14680	COG0504	CTP synthase activity
TX61_RS14710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TX61_RS14715	COG0306	phosphate transporter
TX61_RS14725	COG1253	flavin adenine dinucleotide binding
TX61_RS14740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TX61_RS14745	COG0477	Major facilitator Superfamily
TX61_RS14750	COG1132	(ABC) transporter
TX61_RS14755	COG1136	(ABC) transporter
TX61_RS14775	COG0438	transferase activity, transferring glycosyl groups
TX61_RS14785	COG2264	protein methyltransferase activity
TX61_RS14815	COG2244	polysaccharide biosynthetic process
TX61_RS14865	COG1595	DNA-templated transcription, initiation
TX61_RS14880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TX61_RS14900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TX61_RS14960	COG2201	protein-glutamate methylesterase activity
TX61_RS14980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TX61_RS14985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TX61_RS15015	COG2963	transposase activity
TX61_RS15030	COG4644	lycopene metabolic process
TX61_RS15040	COG1858	cytochrome C peroxidase
TX61_RS15065	COG0515	serine threonine protein kinase
TX61_RS15070	COG0631	protein serine/threonine phosphatase activity
TX61_RS15115	COG3039	Transposase
TX61_RS15170	COG3039	Transposase
TX61_RS15190	COG3039	Transposase
TX61_RS15220	COG2801	Transposase and inactivated derivatives
TX61_RS15245	COG0428	transporter
TX61_RS15250	COG0428	transporter
TX61_RS15255	COG3064	Membrane
TX61_RS15265	COG1530	ribonuclease E activity
TX61_RS15275	COG3293	Transposase
TX61_RS15285	COG1054	Belongs to the UPF0176 family
TX61_RS15290	COG3039	Transposase
TX61_RS15310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TX61_RS15350	COG3039	Transposase
TX61_RS15385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TX61_RS15385	COG1648	precorrin-2 dehydrogenase activity
TX61_RS15410	COG0746	molybdenum cofactor guanylyltransferase activity
TX61_RS15470	COG3328	transposase activity
TX61_RS15475	COG4206	TonB-dependent receptor
TX61_RS15505	COG4206	TonB-dependent receptor
TX61_RS15555	COG0531	amino acid
TX61_RS15570	COG0006	proline dipeptidase activity
TX61_RS15580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TX61_RS15595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX61_RS15600	COG3938	Belongs to the proline racemase family
TX61_RS15610	COG0552	protein localization to endoplasmic reticulum
TX61_RS15630	COG0784	Response regulator, receiver
TX61_RS15630	COG4191	Histidine kinase
TX61_RS15650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TX61_RS15750	COG0438	transferase activity, transferring glycosyl groups
TX61_RS15760	COG0438	transferase activity, transferring glycosyl groups
TX61_RS15765	COG0438	transferase activity, transferring glycosyl groups
TX61_RS15835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TX61_RS15850	COG2963	transposase activity
TX61_RS15875	COG4969	Belongs to the N-Me-Phe pilin family
TX61_RS15915	COG1611	Belongs to the LOG family
TX61_RS15925	COG2095	MarC family integral membrane protein
TX61_RS15935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TX61_RS15970	COG1185	polyribonucleotide nucleotidyltransferase activity
TX61_RS15975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TX61_RS15995	COG0195	Participates in both transcription termination and antitermination
TX61_RS16000	COG0779	Required for maturation of 30S ribosomal subunits
TX61_RS16010	COG1007	ATP synthesis coupled electron transport
TX61_RS16045	COG1034	ATP synthesis coupled electron transport
TX61_RS16050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TX61_RS16055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TX61_RS16060	COG0649	NAD binding
TX61_RS16065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX61_RS16075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX61_RS16090	COG0149	triose-phosphate isomerase activity
TX61_RS16110	COG3293	Transposase
TX61_RS16140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TX61_RS16145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TX61_RS16170	COG0135	phosphoribosylanthranilate isomerase activity
TX61_RS16175	COG0101	tRNA pseudouridine synthase activity
TX61_RS16190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TX61_RS16195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TX61_RS16200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TX61_RS16205	COG2890	protein-(glutamine-N5) methyltransferase activity
TX61_RS16225	COG0433	COG0433 Predicted ATPase
TX61_RS16230	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS16245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TX61_RS16255	COG0412	Dienelactone hydrolase
TX61_RS16275	COG0717	Belongs to the dCTP deaminase family
TX61_RS16280	COG0489	protein tyrosine kinase activity
TX61_RS16315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX61_RS16320	COG2311	Membrane
TX61_RS16325	COG1047	Peptidyl-prolyl cis-trans
TX61_RS16330	COG0791	NLP P60 protein
TX61_RS16335	COG0791	NLP P60 protein
TX61_RS16350	COG1301	dicarboxylic acid transport
TX61_RS16355	COG1785	Belongs to the alkaline phosphatase family
TX61_RS16360	COG0037	tRNA processing
TX61_RS16365	COG1722	exodeoxyribonuclease VII activity
TX61_RS16370	COG0142	geranyltranstransferase activity
TX61_RS16390	COG0312	modulator of DNA gyrase
TX61_RS16395	COG3028	Belongs to the UPF0307 family
TX61_RS16400	COG0312	modulator of DNA gyrase
TX61_RS16405	COG3164	Protein of unknown function
TX61_RS16420	COG2968	Membrane
TX61_RS16435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TX61_RS16455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TX61_RS16480	COG3118	belongs to the thioredoxin family
TX61_RS16500	COG3293	Transposase
TX61_RS16550	COG3293	Transposase
TX61_RS16565	COG3039	Transposase
TX61_RS16570	COG3039	Transposase
TX61_RS16590	COG3293	Transposase
TX61_RS16595	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS16660	COG2022	thiamine diphosphate biosynthetic process
TX61_RS16670	COG3273	potassium ion transport
TX61_RS16670	COG0471	metal ion transport
TX61_RS16695	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS16715	COG3293	Transposase
TX61_RS16725	COG2272	Belongs to the type-B carboxylesterase lipase family
TX61_RS16730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX61_RS16760	COG0308	aminopeptidase N
TX61_RS16765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TX61_RS16775	COG0529	Catalyzes the synthesis of activated sulfate
TX61_RS16775	COG2895	sulfate adenylyltransferase (ATP) activity
TX61_RS16780	COG0175	sulfate reduction
TX61_RS16785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TX61_RS16790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TX61_RS16795	COG0175	sulfate reduction
TX61_RS16815	COG2205	protein histidine kinase activity
TX61_RS16815	COG2198	Histidine kinase
TX61_RS16815	COG0784	Response regulator, receiver
TX61_RS16850	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TX61_RS16855	COG3588	fructose-bisphosphate aldolase
TX61_RS16860	COG0469	pyruvate kinase activity
TX61_RS16900	COG0753	catalase activity
TX61_RS16915	COG3039	Transposase
TX61_RS16935	COG2207	Transcriptional regulator
TX61_RS16935	COG1917	Cupin 2, conserved barrel domain protein
TX61_RS16970	COG1506	peptidase
TX61_RS16970	COG0823	Involved in the tonB-independent uptake of proteins
TX61_RS16990	COG3039	Transposase
TX61_RS16995	COG1297	OPT oligopeptide transporter protein
TX61_RS17100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TX61_RS17120	COG3039	Transposase
TX61_RS17125	COG0732	type I restriction modification DNA specificity domain
TX61_RS17130	COG3039	Transposase
TX61_RS17135	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TX61_RS17140	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TX61_RS17145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TX61_RS17165	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TX61_RS17355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TX61_RS17455	COG2963	transposase activity
TX61_RS17485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TX61_RS17500	COG2197	response regulator
TX61_RS17505	COG4585	Histidine kinase
TX61_RS17520	COG2894	cell division
TX61_RS17525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TX61_RS17535	COG0642	Histidine kinase
TX61_RS17540	COG0745	RESPONSE REGULATOR receiver
TX61_RS17545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TX61_RS17555	COG2194	sulfuric ester hydrolase activity
TX61_RS17585	COG3551	Protein conserved in bacteria
TX61_RS17630	COG2963	transposase activity
TX61_RS17640	COG3293	Transposase
TX61_RS17655	COG0203	ribosomal protein L17
TX61_RS17665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TX61_RS17670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TX61_RS17680	COG0201	protein transport
TX61_RS17690	COG1841	ribosomal large subunit assembly
TX61_RS17720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TX61_RS17730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TX61_RS17735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TX61_RS17740	COG0255	Belongs to the universal ribosomal protein uL29 family
TX61_RS17745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TX61_RS17770	COG0089	rRNA binding
TX61_RS17775	COG0088	Forms part of the polypeptide exit tunnel
TX61_RS17780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TX61_RS17785	COG0051	transcription antitermination factor activity, RNA binding
TX61_RS17805	COG0049	tRNA binding
TX61_RS17810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TX61_RS17815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TX61_RS17820	COG0085	RNA polymerase activity
TX61_RS17825	COG0222	ribosome binding
TX61_RS17830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TX61_RS17840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TX61_RS17845	COG0250	Participates in transcription elongation, termination and antitermination
TX61_RS17850	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TX61_RS17880	COG0012	GTP binding
TX61_RS17885	COG0193	aminoacyl-tRNA hydrolase activity
TX61_RS17895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TX61_RS17910	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TX61_RS17925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TX61_RS17935	COG0521	Mo-molybdopterin cofactor biosynthetic process
TX61_RS17955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TX61_RS17960	COG1295	ribonuclease BN
TX61_RS17985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TX61_RS17995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TX61_RS18025	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TX61_RS18050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TX61_RS18065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TX61_RS18065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TX61_RS18110	COG2890	protein-(glutamine-N5) methyltransferase activity
TX61_RS18120	COG3634	alkyl hydroperoxide reductase activity
TX61_RS18125	COG0583	DNA-binding transcription factor activity
TX61_RS18130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TX61_RS18195	COG4783	chaperone-mediated protein folding
TX61_RS18210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TX61_RS18220	COG0438	transferase activity, transferring glycosyl groups
TX61_RS18225	COG0671	phosphoesterase, PA-phosphatase related
TX61_RS18230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX61_RS18240	COG2833	Protein of unknown function (DUF455)
TX61_RS18260	COG0285	dihydrofolate synthase activity
TX61_RS18265	COG0406	alpha-ribazole phosphatase activity
TX61_RS18295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TX61_RS18300	COG4208	sulfate ABC transporter
TX61_RS18305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TX61_RS18310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TX61_RS18315	COG0156	8-amino-7-oxononanoate synthase activity
TX61_RS18340	COG0604	alcohol dehydrogenase
TX61_RS18345	COG1902	pentaerythritol trinitrate reductase activity
TX61_RS18345	COG0446	pyridine nucleotide-disulphide oxidoreductase
TX61_RS18355	COG2963	transposase activity
TX61_RS18415	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS18425	COG3293	Transposase
TX61_RS18475	COG3386	PFAM SMP-30 Gluconolaconase
TX61_RS18495	COG1024	Enoyl-CoA hydratase
TX61_RS18505	COG0318	PFAM AMP-dependent synthetase and ligase
TX61_RS18510	COG0583	DNA-binding transcription factor activity
TX61_RS18550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TX61_RS18555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TX61_RS18565	COG2096	Adenosyltransferase
TX61_RS18570	COG0123	including yeast histone deacetylase and acetoin utilization protein
TX61_RS18585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TX61_RS18590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TX61_RS18595	COG2967	ApaG domain
TX61_RS18620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TX61_RS18640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TX61_RS18655	COG0642	Histidine kinase
TX61_RS18670	COG4181	ATPase activity
TX61_RS18680	COG2175	clavaminate synthase activity
TX61_RS18690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TX61_RS18715	COG0667	Aldo Keto reductase
TX61_RS18725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TX61_RS18730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TX61_RS18745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TX61_RS18750	COG4106	trans-aconitate 2-methyltransferase activity
TX61_RS18760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TX61_RS18770	COG3293	Transposase
TX61_RS18810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TX61_RS18815	COG2226	methyltransferase
TX61_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS18865	COG0604	alcohol dehydrogenase
TX61_RS18865	COG3321	synthase
TX61_RS18875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TX61_RS18885	COG0494	nUDIX hydrolase
TX61_RS18900	COG1388	LysM domain
TX61_RS18900	COG4942	peptidase
TX61_RS18910	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TX61_RS18925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TX61_RS18930	COG1181	Belongs to the D-alanine--D-alanine ligase family
TX61_RS18935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TX61_RS18955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TX61_RS18970	COG3116	cell division
TX61_RS18975	COG0275	rRNA processing
TX61_RS19005	COG0792	nuclease activity
TX61_RS19010	COG1988	membrane-bound metal-dependent
TX61_RS19015	COG0277	FAD linked oxidase domain protein
TX61_RS19020	COG0745	RESPONSE REGULATOR receiver
TX61_RS19025	COG2205	protein histidine kinase activity
TX61_RS19035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TX61_RS19040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TX61_RS19065	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TX61_RS19070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TX61_RS19075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TX61_RS19095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX61_RS19095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX61_RS19115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TX61_RS19135	COG0488	(ABC) transporter
TX61_RS19160	COG3791	Glutathione-dependent formaldehyde-activating
TX61_RS19185	COG2205	protein histidine kinase activity
TX61_RS19235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TX61_RS19260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TX61_RS19270	COG2963	transposase activity
TX61_RS19275	COG3039	Transposase
TX61_RS19280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TX61_RS19285	COG3293	Transposase
TX61_RS19295	COG3039	Transposase
TX61_RS19305	COG3039	Transposase
TX61_RS19345	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS19350	COG3039	Transposase
TX61_RS19355	COG3293	Transposase
TX61_RS19385	COG1649	PFAM Uncharacterised BCR, COG1649
TX61_RS19385	COG0726	polysaccharide deacetylase
TX61_RS19390	COG1215	transferase activity, transferring glycosyl groups
TX61_RS19400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TX61_RS19405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TX61_RS19410	COG1609	Transcriptional regulator
TX61_RS19420	COG2188	Transcriptional regulator
TX61_RS19435	COG3250	beta-galactosidase activity
TX61_RS19450	COG2963	transposase activity
TX61_RS19460	COG2801	Transposase and inactivated derivatives
TX61_RS19480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TX61_RS19485	COG4191	Histidine kinase
TX61_RS19490	COG0784	Response regulator, receiver
TX61_RS19495	COG4251	negative regulation of phosphorylation
TX61_RS19500	COG2823	Periplasmic or secreted lipoprotein
TX61_RS19505	COG0673	inositol 2-dehydrogenase activity
TX61_RS19510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TX61_RS19550	COG1056	cytidyltransferase-related domain
TX61_RS19550	COG1051	belongs to the nudix hydrolase family
TX61_RS19585	COG2921	Belongs to the UPF0250 family
TX61_RS19595	COG1686	Belongs to the peptidase S11 family
TX61_RS19605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TX61_RS19610	COG2951	lytic endotransglycosylase activity
TX61_RS19645	COG0772	Belongs to the SEDS family
TX61_RS19660	COG1792	Involved in formation and maintenance of cell shape
TX61_RS19665	COG1077	Cell shape determining protein MreB Mrl
TX61_RS19670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TX61_RS19720	COG2199	diguanylate cyclase activity
TX61_RS19725	COG0308	aminopeptidase N
TX61_RS19750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TX61_RS19780	COG0436	Aminotransferase
TX61_RS19790	COG1505	serine-type exopeptidase activity
TX61_RS19815	COG0181	hydroxymethylbilane synthase activity
TX61_RS19825	COG3275	phosphorelay sensor kinase activity
TX61_RS19840	COG3293	Transposase
TX61_RS19865	COG0659	secondary active sulfate transmembrane transporter activity
TX61_RS19870	COG5297	Belongs to the glycosyl hydrolase family 6
TX61_RS19870	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TX61_RS19880	COG0840	transmembrane signaling receptor activity
TX61_RS19910	COG3293	Transposase
TX61_RS19950	COG0598	Magnesium transport protein CorA
TX61_RS19960	COG1113	amino acid transport
TX61_RS19965	COG5297	Belongs to the glycosyl hydrolase family 6
TX61_RS19970	COG4305	rare lipoprotein A
TX61_RS19975	COG0697	spore germination
TX61_RS20035	COG4221	oxidoreductase activity
TX61_RS20045	COG2801	Transposase and inactivated derivatives
TX61_RS20050	COG2963	transposase activity
TX61_RS20070	COG0456	acetyltransferase
TX61_RS20080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TX61_RS20135	COG2111	Na H antiporter
TX61_RS20135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TX61_RS20140	COG1006	Multisubunit Na H antiporter MnhC subunit
TX61_RS20145	COG0651	ATP synthesis coupled electron transport
TX61_RS20155	COG2212	antiporter activity
TX61_RS20160	COG1320	monovalent cation:proton antiporter activity
TX61_RS20165	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TX61_RS20185	COG3104	oligopeptide transport
TX61_RS20190	COG3483	tryptophan 2,3-dioxygenase activity
TX61_RS20200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TX61_RS20215	COG0022	dehydrogenase e1 component
TX61_RS20230	COG0183	Belongs to the thiolase family
TX61_RS20280	COG3039	Transposase
TX61_RS20310	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TX61_RS20315	COG3023	N-Acetylmuramoyl-L-alanine amidase
TX61_RS20325	COG4948	Mandelate Racemase Muconate Lactonizing
TX61_RS20355	COG3293	Transposase
TX61_RS20365	COG0531	amino acid
TX61_RS20400	COG4682	membrane
TX61_RS20405	COG2133	pyrroloquinoline quinone binding
TX61_RS20435	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS20445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TX61_RS20450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TX61_RS20460	COG1610	YqeY-like protein
TX61_RS20465	COG1295	ribonuclease BN
TX61_RS20470	COG0358	DNA primase activity
TX61_RS20530	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TX61_RS20545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TX61_RS20560	COG2963	transposase activity
TX61_RS20565	COG2801	Transposase and inactivated derivatives
TX61_RS20600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TX61_RS20605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TX61_RS20610	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TX61_RS20620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TX61_RS20625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX61_RS20640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TX61_RS20665	COG2963	transposase activity
TX61_RS20670	COG2801	Transposase and inactivated derivatives
TX61_RS20730	COG3039	Transposase
TX61_RS20740	COG3328	transposase activity
TX61_RS20745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TX61_RS20745	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TX61_RS20755	COG1473	amidohydrolase
TX61_RS20760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TX61_RS20765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TX61_RS20775	COG5383	Protein conserved in bacteria
TX61_RS20800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TX61_RS20805	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TX61_RS20820	COG0028	Belongs to the TPP enzyme family
TX61_RS20825	COG4191	Histidine kinase
TX61_RS20850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TX61_RS20865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TX61_RS20870	COG3177	Filamentation induced by cAMP protein fic
TX61_RS20885	COG0596	Alpha beta hydrolase
TX61_RS20890	COG0727	PFAM Uncharacterised protein family (UPF0153)
TX61_RS20895	COG0318	PFAM AMP-dependent synthetase and ligase
TX61_RS20900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX61_RS20955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TX61_RS20965	COG0129	dihydroxy-acid dehydratase activity
TX61_RS20985	COG3039	Transposase
TX61_RS21000	COG0408	coproporphyrinogen oxidase activity
TX61_RS21015	COG2801	Transposase and inactivated derivatives
TX61_RS21020	COG2963	transposase activity
TX61_RS21105	COG2353	YceI-like domain
TX61_RS21145	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TX61_RS21160	COG3386	PFAM SMP-30 Gluconolaconase
TX61_RS21205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TX61_RS21215	COG4771	TonB-dependent receptor
TX61_RS21225	COG0459	protein refolding
TX61_RS21255	COG1252	NADH dehydrogenase
TX61_RS21265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX61_RS21270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TX61_RS21275	COG2201	protein-glutamate methylesterase activity
TX61_RS21280	COG2177	Part of the ABC transporter FtsEX involved in
TX61_RS21285	COG2884	Cell division ATP-binding protein ftsE
TX61_RS21295	COG3118	belongs to the thioredoxin family
TX61_RS21300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TX61_RS21320	COG0729	surface antigen
TX61_RS21325	COG2911	Protein conserved in bacteria
TX61_RS21355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TX61_RS21370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TX61_RS21425	COG1733	regulation of RNA biosynthetic process
TX61_RS21430	COG0702	epimerase
TX61_RS21465	COG0583	DNA-binding transcription factor activity
TX61_RS21470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TX61_RS21480	COG2205	protein histidine kinase activity
TX61_RS21485	COG2205	protein histidine kinase activity
TX61_RS21490	COG0745	RESPONSE REGULATOR receiver
TX61_RS21510	COG1902	pentaerythritol trinitrate reductase activity
TX61_RS21515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TX61_RS21525	COG2814	Major facilitator Superfamily
TX61_RS21530	COG0583	DNA-binding transcription factor activity
TX61_RS21540	COG0084	hydrolase, TatD family'
TX61_RS21570	COG3293	Transposase
TX61_RS21590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TX61_RS21610	COG2351	hydroxyisourate hydrolase activity
TX61_RS21645	COG2826	transposase and inactivated derivatives, IS30 family
TX61_RS21655	COG4770	biotin carboxylase activity
TX61_RS21660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TX61_RS21665	COG1960	acyl-CoA dehydrogenase activity
TX61_RS21725	COG0523	cobalamin synthesis protein
TX61_RS21735	COG0697	spore germination
TX61_RS21745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TX61_RS21760	COG4771	TonB-dependent receptor
TX61_RS21765	COG0457	Tetratricopeptide repeat
TX61_RS21780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TX61_RS21795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TX61_RS21795	COG0519	Catalyzes the synthesis of GMP from XMP
TX61_RS21805	COG0805	protein transport
TX61_RS21815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TX61_RS21825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TX61_RS21865	COG3661	Belongs to the glycosyl hydrolase 67 family
TX61_RS21875	COG4948	Mandelate Racemase Muconate Lactonizing
TX61_RS21885	COG1472	Belongs to the glycosyl hydrolase 3 family
TX61_RS21890	COG0246	Mannitol dehydrogenase
TX61_RS21915	COG3693	PFAM glycoside hydrolase, family 10
TX61_RS21920	COG3693	PFAM glycoside hydrolase, family 10
TX61_RS21940	COG2211	Major facilitator Superfamily
TX61_RS21980	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TX61_RS22025	COG1846	Transcriptional regulator
TX61_RS22030	COG1764	response to oxidative stress
TX61_RS22115	COG3549	Plasmid maintenance system killer
TX61_RS22125	COG1074	ATP-dependent DNA helicase activity
TX61_RS22130	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TX61_RS22170	COG2032	superoxide dismutase activity
TX61_RS22175	COG2032	superoxide dismutase activity
TX61_RS22180	COG2204	response regulator
TX61_RS22185	COG3852	Histidine kinase
TX61_RS22190	COG0004	ammonium transporteR
TX61_RS22195	COG0347	Belongs to the P(II) protein family
TX61_RS22200	COG0174	glutamine synthetase
TX61_RS22205	COG1968	undecaprenyl-diphosphatase activity
TX61_RS22250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TX61_RS22260	COG2062	phosphohistidine phosphatase, SixA
TX61_RS22265	COG0489	protein tyrosine kinase activity
TX61_RS22290	COG1396	sequence-specific DNA binding
TX61_RS22295	COG3550	peptidyl-serine autophosphorylation
TX61_RS22300	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TX61_RS22305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TX61_RS22320	COG0517	IMP dehydrogenase activity
TX61_RS22320	COG1125	glycine betaine transport
TX61_RS22335	COG1119	ATPase activity
TX61_RS22345	COG1752	Esterase of the alpha-beta hydrolase superfamily
TX61_RS22360	COG3039	Transposase
TX61_RS22370	COG2963	transposase activity
TX61_RS22385	COG0656	L-ascorbic acid biosynthetic process
TX61_RS22390	COG2130	NADP-dependent
TX61_RS22395	COG0667	Aldo Keto reductase
TX61_RS22405	COG1187	pseudouridine synthase activity
TX61_RS22420	COG1643	Atp-dependent helicase
TX61_RS22425	COG4807	Protein conserved in bacteria
TX61_RS22430	COG4948	Mandelate Racemase Muconate Lactonizing
TX61_RS22435	COG0179	Fumarylacetoacetate (FAA) hydrolase
TX61_RS22440	COG1028	Short-chain dehydrogenase reductase Sdr
TX61_RS22460	COG3507	Belongs to the glycosyl hydrolase 43 family
TX61_RS22500	COG3162	membrane
TX61_RS22505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TX61_RS22515	COG0708	Exodeoxyribonuclease III
TX61_RS22530	COG2091	lysine biosynthetic process via aminoadipic acid
TX61_RS22540	COG3540	Alkaline phosphatase
TX61_RS22570	COG2159	amidohydrolase
TX61_RS22580	COG2159	amidohydrolase
TX61_RS22590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TX61_RS22595	COG0583	DNA-binding transcription factor activity
TX61_RS22600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TX61_RS22615	COG0210	DNA helicase
TX61_RS22630	COG0531	amino acid
TX61_RS22635	COG1322	Protein conserved in bacteria
TX61_RS22645	COG0386	Belongs to the glutathione peroxidase family
TX61_RS22695	COG0793	Belongs to the peptidase S41A family
TX61_RS22700	COG4942	peptidase
TX61_RS22710	COG2234	aminopeptidase activity
TX61_RS22760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TX61_RS22765	COG0302	gtp cyclohydrolase
TX61_RS22790	COG0477	Major facilitator Superfamily
TX61_RS22800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TX61_RS22875	COG1929	Belongs to the glycerate kinase type-1 family
TX61_RS22880	COG2271	Major facilitator Superfamily
TX61_RS22895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TX61_RS22900	COG0861	Integral membrane protein TerC family
TX61_RS22910	COG0584	glycerophosphoryl diester phosphodiesterase
TX61_RS22920	COG0671	phosphoesterase, PA-phosphatase related
TX61_RS22930	COG0726	polysaccharide deacetylase
TX61_RS22955	COG1116	anion transmembrane transporter activity