locus-tag	class	description
C0L89_RS00025	COG0187	DNA topoisomerase II activity
C0L89_RS00035	COG0501	Belongs to the peptidase M48B family
C0L89_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C0L89_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0L89_RS00095	COG3039	Transposase
C0L89_RS00135	COG0793	Belongs to the peptidase S41A family
C0L89_RS00140	COG4942	peptidase
C0L89_RS00150	COG2234	aminopeptidase activity
C0L89_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C0L89_RS00175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C0L89_RS00185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C0L89_RS00195	COG1064	alcohol dehydrogenase
C0L89_RS00225	COG0493	'glutamate synthase
C0L89_RS00230	COG0069	glutamate synthase activity
C0L89_RS00230	COG0067	glutamate synthase
C0L89_RS00230	COG0070	glutamate synthase
C0L89_RS00300	COG1205	dead DEAH box helicase
C0L89_RS00300	COG1111	helicase
C0L89_RS00305	COG1272	protein, Hemolysin III
C0L89_RS00335	COG2032	superoxide dismutase activity
C0L89_RS00340	COG2204	response regulator
C0L89_RS00345	COG3852	Histidine kinase
C0L89_RS00350	COG0004	ammonium transporteR
C0L89_RS00355	COG0347	Belongs to the P(II) protein family
C0L89_RS00360	COG0174	glutamine synthetase
C0L89_RS00365	COG1968	undecaprenyl-diphosphatase activity
C0L89_RS00415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0L89_RS00425	COG2062	phosphohistidine phosphatase, SixA
C0L89_RS00430	COG0489	protein tyrosine kinase activity
C0L89_RS00450	COG1396	sequence-specific DNA binding
C0L89_RS00455	COG3550	peptidyl-serine autophosphorylation
C0L89_RS00460	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C0L89_RS00465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C0L89_RS00480	COG1125	glycine betaine transport
C0L89_RS00495	COG1119	ATPase activity
C0L89_RS00510	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0L89_RS00520	COG1522	sequence-specific DNA binding
C0L89_RS00525	COG3186	Phenylalanine-4-hydroxylase
C0L89_RS00555	COG1609	Transcriptional regulator
C0L89_RS00595	COG0366	Alpha amylase catalytic
C0L89_RS00600	COG0366	Alpha amylase catalytic
C0L89_RS00610	COG3039	Transposase
C0L89_RS00660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0L89_RS00665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C0L89_RS00680	COG0028	Belongs to the TPP enzyme family
C0L89_RS00685	COG4191	Histidine kinase
C0L89_RS00710	COG3039	Transposase
C0L89_RS00720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0L89_RS00735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0L89_RS00740	COG3177	Filamentation induced by cAMP protein fic
C0L89_RS00745	COG0596	Alpha beta hydrolase
C0L89_RS00755	COG0727	PFAM Uncharacterised protein family (UPF0153)
C0L89_RS00760	COG0318	PFAM AMP-dependent synthetase and ligase
C0L89_RS00765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0L89_RS00780	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0L89_RS00795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0L89_RS00810	COG0564	pseudouridine synthase activity
C0L89_RS00840	COG0339	signal peptide processing
C0L89_RS00885	COG4770	biotin carboxylase activity
C0L89_RS00895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0L89_RS00900	COG1960	acyl-CoA dehydrogenase activity
C0L89_RS00945	COG0523	cobalamin synthesis protein
C0L89_RS00955	COG0697	spore germination
C0L89_RS00965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C0L89_RS00970	COG1846	Transcriptional regulator
C0L89_RS00975	COG1764	response to oxidative stress
C0L89_RS01025	COG0656	L-ascorbic acid biosynthetic process
C0L89_RS01040	COG2130	NADP-dependent
C0L89_RS01055	COG1187	pseudouridine synthase activity
C0L89_RS01070	COG1643	Atp-dependent helicase
C0L89_RS01080	COG4807	Protein conserved in bacteria
C0L89_RS01085	COG2072	flavoprotein involved in K transport
C0L89_RS01105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0L89_RS01110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0L89_RS01150	COG3039	Transposase
C0L89_RS01195	COG0084	hydrolase, TatD family'
C0L89_RS01215	COG0583	DNA-binding transcription factor activity
C0L89_RS01220	COG2814	Major facilitator Superfamily
C0L89_RS01230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0L89_RS01235	COG1902	pentaerythritol trinitrate reductase activity
C0L89_RS01265	COG0745	RESPONSE REGULATOR receiver
C0L89_RS01285	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C0L89_RS01290	COG0583	DNA-binding transcription factor activity
C0L89_RS01320	COG0702	epimerase
C0L89_RS01325	COG1733	regulation of RNA biosynthetic process
C0L89_RS01360	COG3039	Transposase
C0L89_RS01395	COG0129	dihydroxy-acid dehydratase activity
C0L89_RS01405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0L89_RS01475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0L89_RS01490	COG3485	protocatechuate 3,4-dioxygenase
C0L89_RS01495	COG3485	protocatechuate 3,4-dioxygenase
C0L89_RS01510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0L89_RS01515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0L89_RS01530	COG1414	Transcriptional regulator
C0L89_RS01570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0L89_RS01610	COG0156	8-amino-7-oxononanoate synthase activity
C0L89_RS01615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0L89_RS01620	COG1040	competence protein
C0L89_RS01625	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0L89_RS01730	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0L89_RS01805	COG3264	Mechanosensitive ion channel
C0L89_RS01805	COG1511	domain protein
C0L89_RS01815	COG3039	Transposase
C0L89_RS01820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0L89_RS01830	COG2354	Protein conserved in bacteria
C0L89_RS01855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C0L89_RS01880	COG0702	epimerase
C0L89_RS01890	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS01920	COG0513	Belongs to the DEAD box helicase family
C0L89_RS01930	COG3039	Transposase
C0L89_RS01960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C0L89_RS01970	COG3483	tryptophan 2,3-dioxygenase activity
C0L89_RS01975	COG3104	oligopeptide transport
C0L89_RS01995	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C0L89_RS02005	COG1320	monovalent cation:proton antiporter activity
C0L89_RS02010	COG2212	antiporter activity
C0L89_RS02020	COG0651	ATP synthesis coupled electron transport
C0L89_RS02025	COG1006	Multisubunit Na H antiporter MnhC subunit
C0L89_RS02030	COG2111	Na H antiporter
C0L89_RS02030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0L89_RS02065	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C0L89_RS02075	COG0456	acetyltransferase
C0L89_RS02115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0L89_RS02120	COG0134	indole-3-glycerol-phosphate synthase activity
C0L89_RS02130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0L89_RS02135	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C0L89_RS02145	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C0L89_RS02150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0L89_RS02155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0L89_RS02225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C0L89_RS02245	COG2814	Major facilitator Superfamily
C0L89_RS02255	COG2814	Major facilitator Superfamily
C0L89_RS02260	COG1289	transmembrane transporter activity
C0L89_RS02270	COG0151	Belongs to the GarS family
C0L89_RS02280	COG0419	ATPase involved in DNA repair
C0L89_RS02285	COG0138	bifunctional purine biosynthesis protein purh
C0L89_RS02290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0L89_RS02300	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C0L89_RS02355	COG0439	Biotin carboxylase
C0L89_RS02365	COG0511	ligase activity, forming carbon-carbon bonds
C0L89_RS02370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0L89_RS02385	COG1324	tolerance protein
C0L89_RS02405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0L89_RS02425	COG0534	Mate efflux family protein
C0L89_RS02430	COG0616	signal peptide processing
C0L89_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS02455	COG0009	L-threonylcarbamoyladenylate synthase
C0L89_RS02460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0L89_RS02460	COG1754	DNA topoisomerase type I activity
C0L89_RS02480	COG0758	DNA mediated transformation
C0L89_RS02485	COG1652	LysM domain
C0L89_RS02490	COG0242	peptide deformylase activity
C0L89_RS02495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0L89_RS02500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0L89_RS02500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0L89_RS02550	COG1560	Kdo2-lipid A biosynthetic process
C0L89_RS02560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0L89_RS02730	COG3179	chitinase
C0L89_RS02775	COG4695	Portal protein
C0L89_RS02855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C0L89_RS02860	COG3118	belongs to the thioredoxin family
C0L89_RS02870	COG2884	Cell division ATP-binding protein ftsE
C0L89_RS02875	COG2177	Part of the ABC transporter FtsEX involved in
C0L89_RS02880	COG3437	response regulator, receiver
C0L89_RS02885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0L89_RS02890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0L89_RS02895	COG2860	membrane
C0L89_RS02900	COG1252	NADH dehydrogenase
C0L89_RS02925	COG0459	protein refolding
C0L89_RS02940	COG3039	Transposase
C0L89_RS02955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0L89_RS02985	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C0L89_RS03020	COG2353	YceI-like domain
C0L89_RS03130	COG4221	oxidoreductase activity
C0L89_RS03185	COG0697	spore germination
C0L89_RS03190	COG4305	rare lipoprotein A
C0L89_RS03195	COG5297	Belongs to the glycosyl hydrolase family 6
C0L89_RS03205	COG1113	amino acid transport
C0L89_RS03215	COG0598	Magnesium transport protein CorA
C0L89_RS03290	COG5001	Diguanylate cyclase
C0L89_RS03290	COG3300	MHYT domain
C0L89_RS03315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C0L89_RS03315	COG5297	Belongs to the glycosyl hydrolase family 6
C0L89_RS03320	COG0659	secondary active sulfate transmembrane transporter activity
C0L89_RS03355	COG3275	phosphorelay sensor kinase activity
C0L89_RS03365	COG0181	hydroxymethylbilane synthase activity
C0L89_RS03390	COG1505	serine-type exopeptidase activity
C0L89_RS03400	COG0436	Aminotransferase
C0L89_RS03410	COG2832	Protein of unknown function (DUF454)
C0L89_RS03430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C0L89_RS03440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C0L89_RS03475	COG3300	MHYT domain
C0L89_RS03475	COG5001	Diguanylate cyclase
C0L89_RS03480	COG0308	aminopeptidase N
C0L89_RS03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0L89_RS03500	COG1077	Cell shape determining protein MreB Mrl
C0L89_RS03505	COG1792	Involved in formation and maintenance of cell shape
C0L89_RS03520	COG0772	Belongs to the SEDS family
C0L89_RS03545	COG2951	lytic endotransglycosylase activity
C0L89_RS03550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0L89_RS03555	COG1686	Belongs to the peptidase S11 family
C0L89_RS03570	COG2921	Belongs to the UPF0250 family
C0L89_RS03595	COG1056	cytidyltransferase-related domain
C0L89_RS03595	COG1051	belongs to the nudix hydrolase family
C0L89_RS03630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C0L89_RS03635	COG0673	inositol 2-dehydrogenase activity
C0L89_RS03640	COG2823	Periplasmic or secreted lipoprotein
C0L89_RS03645	COG4251	negative regulation of phosphorylation
C0L89_RS03650	COG0784	Response regulator, receiver
C0L89_RS03655	COG4191	Histidine kinase
C0L89_RS03660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0L89_RS03685	COG3039	Transposase
C0L89_RS03705	COG3250	beta-galactosidase activity
C0L89_RS03720	COG2188	Transcriptional regulator
C0L89_RS03730	COG1609	Transcriptional regulator
C0L89_RS03735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0L89_RS03740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0L89_RS03755	COG1215	transferase activity, transferring glycosyl groups
C0L89_RS03760	COG0726	polysaccharide deacetylase
C0L89_RS03760	COG1649	PFAM Uncharacterised BCR, COG1649
C0L89_RS03780	COG3039	Transposase
C0L89_RS03825	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0L89_RS03865	COG2205	protein histidine kinase activity
C0L89_RS03895	COG3791	Glutathione-dependent formaldehyde-activating
C0L89_RS03910	COG3039	Transposase
C0L89_RS03925	COG0488	(ABC) transporter
C0L89_RS03945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0L89_RS03955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0L89_RS03965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0L89_RS03965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0L89_RS03985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0L89_RS03990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0L89_RS03995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C0L89_RS04020	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C0L89_RS04025	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C0L89_RS04035	COG2205	protein histidine kinase activity
C0L89_RS04040	COG0745	RESPONSE REGULATOR receiver
C0L89_RS04070	COG0277	FAD linked oxidase domain protein
C0L89_RS04080	COG0792	nuclease activity
C0L89_RS04120	COG0275	rRNA processing
C0L89_RS04125	COG3116	cell division
C0L89_RS04140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0L89_RS04145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0L89_RS04160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0L89_RS04165	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0L89_RS04170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0L89_RS04185	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C0L89_RS04195	COG0739	heme binding
C0L89_RS04195	COG0741	lytic transglycosylase activity
C0L89_RS04195	COG1196	nuclear chromosome segregation
C0L89_RS04210	COG0494	nUDIX hydrolase
C0L89_RS04225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C0L89_RS04240	COG0604	alcohol dehydrogenase
C0L89_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS04240	COG3321	synthase
C0L89_RS04300	COG2226	methyltransferase
C0L89_RS04305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C0L89_RS04345	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS04370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0L89_RS04385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0L89_RS04395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0L89_RS04400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0L89_RS04410	COG0667	Aldo Keto reductase
C0L89_RS04440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C0L89_RS04450	COG2175	clavaminate synthase activity
C0L89_RS04460	COG4181	ATPase activity
C0L89_RS04475	COG0642	Histidine kinase
C0L89_RS04490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C0L89_RS04510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0L89_RS04530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0L89_RS04535	COG2967	ApaG domain
C0L89_RS04540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0L89_RS04555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C0L89_RS04570	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0L89_RS04575	COG2096	Adenosyltransferase
C0L89_RS04590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0L89_RS04595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0L89_RS04615	COG1802	Transcriptional regulator
C0L89_RS04625	COG3384	dioxygenase
C0L89_RS04630	COG0583	DNA-binding transcription factor activity
C0L89_RS04635	COG0318	PFAM AMP-dependent synthetase and ligase
C0L89_RS04645	COG1024	Enoyl-CoA hydratase
C0L89_RS04665	COG3386	PFAM SMP-30 Gluconolaconase
C0L89_RS04715	COG2197	response regulator
C0L89_RS04725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0L89_RS04730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0L89_RS04735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0L89_RS04745	COG0583	DNA-binding transcription factor activity
C0L89_RS04750	COG3634	alkyl hydroperoxide reductase activity
C0L89_RS04760	COG2890	protein-(glutamine-N5) methyltransferase activity
C0L89_RS04800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0L89_RS04800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0L89_RS04815	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C0L89_RS04870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0L89_RS04880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0L89_RS04910	COG1295	ribonuclease BN
C0L89_RS04915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0L89_RS04920	COG1254	Belongs to the acylphosphatase family
C0L89_RS04935	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0L89_RS04945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0L89_RS04950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0L89_RS04960	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C0L89_RS04975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0L89_RS04985	COG0193	aminoacyl-tRNA hydrolase activity
C0L89_RS04990	COG0012	GTP binding
C0L89_RS05025	COG0250	Participates in transcription elongation, termination and antitermination
C0L89_RS05035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0L89_RS05040	COG0081	regulation of translation
C0L89_RS05045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0L89_RS05055	COG0085	RNA polymerase activity
C0L89_RS05060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0L89_RS05065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0L89_RS05070	COG0049	tRNA binding
C0L89_RS05105	COG0088	Forms part of the polypeptide exit tunnel
C0L89_RS05110	COG0089	rRNA binding
C0L89_RS05115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0L89_RS05125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0L89_RS05135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0L89_RS05140	COG0255	Belongs to the universal ribosomal protein uL29 family
C0L89_RS05145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0L89_RS05150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0L89_RS05155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0L89_RS05190	COG1841	ribosomal large subunit assembly
C0L89_RS05195	COG0200	Binds to the 23S rRNA
C0L89_RS05200	COG0201	protein transport
C0L89_RS05210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0L89_RS05215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0L89_RS05225	COG0203	ribosomal protein L17
C0L89_RS05240	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C0L89_RS05260	COG1217	gtp-binding protein TYPA
C0L89_RS05265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0L89_RS05275	COG0625	glutathione transferase activity
C0L89_RS05305	COG3039	Transposase
C0L89_RS05325	COG1902	pentaerythritol trinitrate reductase activity
C0L89_RS05325	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0L89_RS05330	COG0604	alcohol dehydrogenase
C0L89_RS05360	COG0156	8-amino-7-oxononanoate synthase activity
C0L89_RS05365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0L89_RS05370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C0L89_RS05375	COG4208	sulfate ABC transporter
C0L89_RS05380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C0L89_RS05415	COG0406	alpha-ribazole phosphatase activity
C0L89_RS05425	COG0285	dihydrofolate synthase activity
C0L89_RS05445	COG2833	Protein of unknown function (DUF455)
C0L89_RS05470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0L89_RS05475	COG0671	phosphoesterase, PA-phosphatase related
C0L89_RS05480	COG0438	transferase activity, transferring glycosyl groups
C0L89_RS05490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C0L89_RS05495	COG5002	protein histidine kinase activity
C0L89_RS05505	COG4783	chaperone-mediated protein folding
C0L89_RS05520	COG0473	3-isopropylmalate dehydrogenase activity
C0L89_RS05565	COG3039	Transposase
C0L89_RS05590	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0L89_RS05630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0L89_RS05655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0L89_RS05670	COG0631	protein serine/threonine phosphatase activity
C0L89_RS05705	COG0859	PFAM glycosyl transferase family 9
C0L89_RS05710	COG3642	lipopolysaccharide core region biosynthetic process
C0L89_RS05715	COG1234	tRNA 3'-trailer cleavage
C0L89_RS05720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0L89_RS05730	COG0315	cyclic pyranopterin monophosphate synthase activity
C0L89_RS05735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C0L89_RS05740	COG0314	molybdopterin synthase activity
C0L89_RS05775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0L89_RS05785	COG0537	adenosine 5'-monophosphoramidase activity
C0L89_RS05805	COG0714	Associated with various cellular activities
C0L89_RS05825	COG1399	metal-binding, possibly nucleic acid-binding protein
C0L89_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS05855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0L89_RS05865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0L89_RS05870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0L89_RS05900	COG3829	transcription factor binding
C0L89_RS06000	COG0330	HflC and HflK could
C0L89_RS06005	COG0330	HflC and HflK could
C0L89_RS06015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0L89_RS06020	COG0308	aminopeptidase N
C0L89_RS06045	COG0732	type I restriction modification DNA specificity domain
C0L89_RS06060	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C0L89_RS06145	COG0587	DNA-directed DNA polymerase activity
C0L89_RS06165	COG1297	OPT oligopeptide transporter protein
C0L89_RS06180	COG1506	peptidase
C0L89_RS06180	COG0823	Involved in the tonB-independent uptake of proteins
C0L89_RS06190	COG2207	Transcriptional regulator
C0L89_RS06190	COG1917	Cupin 2, conserved barrel domain protein
C0L89_RS06235	COG0753	catalase activity
C0L89_RS06275	COG3551	Protein conserved in bacteria
C0L89_RS06305	COG2194	sulfuric ester hydrolase activity
C0L89_RS06315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0L89_RS06320	COG0745	RESPONSE REGULATOR receiver
C0L89_RS06325	COG0642	Histidine kinase
C0L89_RS06335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C0L89_RS06340	COG2894	cell division
C0L89_RS06355	COG4585	Histidine kinase
C0L89_RS06360	COG2197	response regulator
C0L89_RS06375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C0L89_RS06400	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C0L89_RS06470	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS06495	COG3039	Transposase
C0L89_RS06615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C0L89_RS06630	COG1842	Phage shock protein A
C0L89_RS06655	COG0754	glutathionylspermidine amidase activity
C0L89_RS06735	COG0531	amino acid
C0L89_RS06740	COG2197	response regulator
C0L89_RS06745	COG2267	carboxylic ester hydrolase activity
C0L89_RS06755	COG1113	amino acid transport
C0L89_RS06785	COG3039	Transposase
C0L89_RS06795	COG1294	oxidase, subunit
C0L89_RS06805	COG2239	Acts as a magnesium transporter
C0L89_RS06815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0L89_RS06820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0L89_RS06835	COG3039	Transposase
C0L89_RS06850	COG1660	Displays ATPase and GTPase activities
C0L89_RS06860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0L89_RS06875	COG1137	ATPase activity
C0L89_RS06880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C0L89_RS06890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C0L89_RS06900	COG0271	Belongs to the BolA IbaG family
C0L89_RS06905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0L89_RS06930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0L89_RS06945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0L89_RS06955	COG0628	permease
C0L89_RS06965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C0L89_RS06970	COG3178	'Phosphotransferase
C0L89_RS06980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0L89_RS06985	COG1555	photosystem II stabilization
C0L89_RS07010	COG3039	Transposase
C0L89_RS07020	COG2146	nitrite reductase [NAD(P)H] activity
C0L89_RS07035	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS07045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0L89_RS07050	COG0719	Fe-S assembly protein
C0L89_RS07055	COG0396	ATPase activity
C0L89_RS07060	COG0719	Fe-S assembly protein
C0L89_RS07065	COG1959	2 iron, 2 sulfur cluster binding
C0L89_RS07120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C0L89_RS07155	COG0519	Catalyzes the synthesis of GMP from XMP
C0L89_RS07170	COG1678	Uncharacterized ACR, COG1678
C0L89_RS07175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0L89_RS07190	COG1764	response to oxidative stress
C0L89_RS07200	COG0384	phenazine biosynthesis protein PhzF
C0L89_RS07210	COG0527	aspartate kinase activity
C0L89_RS07240	COG3039	Transposase
C0L89_RS07250	COG0142	geranyltranstransferase activity
C0L89_RS07255	COG0629	single-stranded DNA binding
C0L89_RS07260	COG4251	negative regulation of phosphorylation
C0L89_RS07260	COG5001	Diguanylate cyclase
C0L89_RS07260	COG3706	GGDEF domain
C0L89_RS07260	COG2203	Gaf domain
C0L89_RS07305	COG2879	small protein
C0L89_RS07310	COG1966	Carbon starvation protein
C0L89_RS07315	COG1741	Belongs to the pirin family
C0L89_RS07420	COG1515	deoxyribonuclease V activity
C0L89_RS07440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0L89_RS07445	COG2199	diguanylate cyclase activity
C0L89_RS07445	COG2202	Pas domain
C0L89_RS07445	COG2200	EAL domain
C0L89_RS07450	COG0835	chemotaxis
C0L89_RS07455	COG0840	transmembrane signaling receptor activity
C0L89_RS07465	COG0643	Histidine kinase
C0L89_RS07465	COG2198	Histidine kinase
C0L89_RS07475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C0L89_RS07485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C0L89_RS07520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0L89_RS07525	COG0735	belongs to the Fur family
C0L89_RS07555	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS07700	COG5002	protein histidine kinase activity
C0L89_RS07700	COG5001	Diguanylate cyclase
C0L89_RS07705	COG1187	pseudouridine synthase activity
C0L89_RS07725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0L89_RS07735	COG0475	glutathione-regulated potassium exporter activity
C0L89_RS07740	COG5000	phosphorelay sensor kinase activity
C0L89_RS07740	COG5002	protein histidine kinase activity
C0L89_RS07745	COG0745	RESPONSE REGULATOR receiver
C0L89_RS07750	COG1538	Outer membrane efflux protein
C0L89_RS07775	COG1132	(ABC) transporter
C0L89_RS07840	COG3118	belongs to the thioredoxin family
C0L89_RS07870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0L89_RS07890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C0L89_RS07915	COG2968	Membrane
C0L89_RS07930	COG3164	Protein of unknown function
C0L89_RS07940	COG0312	modulator of DNA gyrase
C0L89_RS07945	COG3028	Belongs to the UPF0307 family
C0L89_RS07950	COG0312	modulator of DNA gyrase
C0L89_RS07965	COG4104	PAAR repeat-containing protein
C0L89_RS07975	COG0142	geranyltranstransferase activity
C0L89_RS07980	COG1722	exodeoxyribonuclease VII activity
C0L89_RS07985	COG0037	tRNA processing
C0L89_RS07990	COG1785	Belongs to the alkaline phosphatase family
C0L89_RS07995	COG1301	dicarboxylic acid transport
C0L89_RS08000	COG4106	trans-aconitate 2-methyltransferase activity
C0L89_RS08010	COG0791	NLP P60 protein
C0L89_RS08015	COG0791	NLP P60 protein
C0L89_RS08020	COG1047	Peptidyl-prolyl cis-trans
C0L89_RS08025	COG2311	Membrane
C0L89_RS08030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0L89_RS08060	COG3039	Transposase
C0L89_RS08070	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS08100	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS08105	COG3039	Transposase
C0L89_RS08120	COG0489	protein tyrosine kinase activity
C0L89_RS08130	COG0717	Belongs to the dCTP deaminase family
C0L89_RS08145	COG3039	Transposase
C0L89_RS08165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0L89_RS08175	COG3039	Transposase
C0L89_RS08185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0L89_RS08205	COG0433	COG0433 Predicted ATPase
C0L89_RS08235	COG2890	protein-(glutamine-N5) methyltransferase activity
C0L89_RS08240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0L89_RS08245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0L89_RS08250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0L89_RS08270	COG0101	tRNA pseudouridine synthase activity
C0L89_RS08275	COG0135	phosphoribosylanthranilate isomerase activity
C0L89_RS08285	COG0133	tryptophan synthase activity
C0L89_RS08300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C0L89_RS08305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0L89_RS08365	COG0149	triose-phosphate isomerase activity
C0L89_RS08380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0L89_RS08390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0L89_RS08395	COG0649	NAD binding
C0L89_RS08400	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C0L89_RS08405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C0L89_RS08410	COG1034	ATP synthesis coupled electron transport
C0L89_RS08415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0L89_RS08420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0L89_RS08445	COG1007	ATP synthesis coupled electron transport
C0L89_RS08455	COG0779	Required for maturation of 30S ribosomal subunits
C0L89_RS08460	COG0195	Participates in both transcription termination and antitermination
C0L89_RS08465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0L89_RS08480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0L89_RS08485	COG1185	polyribonucleotide nucleotidyltransferase activity
C0L89_RS08520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0L89_RS08530	COG2095	MarC family integral membrane protein
C0L89_RS08545	COG1611	Belongs to the LOG family
C0L89_RS08590	COG4969	Belongs to the N-Me-Phe pilin family
C0L89_RS08595	COG0556	nucleotide-excision repair
C0L89_RS08625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C0L89_RS08635	COG2986	histidine ammonia-lyase
C0L89_RS08640	COG1228	amidohydrolase
C0L89_RS08685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C0L89_RS08690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C0L89_RS08695	COG0077	Prephenate dehydratase
C0L89_RS08695	COG1605	Chorismate mutase
C0L89_RS08700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0L89_RS08725	COG3039	Transposase
C0L89_RS08735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0L89_RS08750	COG0583	DNA-binding transcription factor activity
C0L89_RS08765	COG2336	PFAM SpoVT AbrB
C0L89_RS08810	COG0840	transmembrane signaling receptor activity
C0L89_RS08835	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C0L89_RS08840	COG0784	Response regulator, receiver
C0L89_RS08840	COG4191	Histidine kinase
C0L89_RS08855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0L89_RS08875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0L89_RS08890	COG1595	DNA-templated transcription, initiation
C0L89_RS08940	COG2244	polysaccharide biosynthetic process
C0L89_RS08970	COG2264	protein methyltransferase activity
C0L89_RS08980	COG0438	transferase activity, transferring glycosyl groups
C0L89_RS08995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C0L89_RS09000	COG1132	(ABC) transporter
C0L89_RS09010	COG2271	Major facilitator Superfamily
C0L89_RS09030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0L89_RS09045	COG1253	flavin adenine dinucleotide binding
C0L89_RS09060	COG0306	phosphate transporter
C0L89_RS09090	COG0504	CTP synthase activity
C0L89_RS09095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C0L89_RS09100	COG0148	phosphopyruvate hydratase activity
C0L89_RS09105	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C0L89_RS09120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0L89_RS09130	COG2840	Smr protein MutS2
C0L89_RS09135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C0L89_RS09140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0L89_RS09145	COG1238	metal cluster binding
C0L89_RS09160	COG1534	Rna-binding protein
C0L89_RS09165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C0L89_RS09175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0L89_RS09190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0L89_RS09195	COG1546	Belongs to the CinA family
C0L89_RS09210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C0L89_RS09220	COG2137	regulation of response to DNA damage stimulus
C0L89_RS09225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0L89_RS09230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C0L89_RS09285	COG1741	Belongs to the pirin family
C0L89_RS09290	COG0583	DNA-binding transcription factor activity
C0L89_RS09315	COG0352	thiamine-phosphate diphosphorylase activity
C0L89_RS09315	COG0351	phosphomethylpyrimidine kinase
C0L89_RS09325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0L89_RS09330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0L89_RS09345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0L89_RS09355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C0L89_RS09360	COG3734	2-keto-3-deoxy-galactonokinase
C0L89_RS09370	COG4948	Mandelate Racemase Muconate Lactonizing
C0L89_RS09375	COG0800	Aldolase
C0L89_RS09400	COG1070	Carbohydrate kinase
C0L89_RS09410	COG0477	Major facilitator Superfamily
C0L89_RS09430	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0L89_RS09435	COG1469	GTP cyclohydrolase I activity
C0L89_RS09445	COG0617	tRNA 3'-terminal CCA addition
C0L89_RS09465	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C0L89_RS09495	COG1472	Belongs to the glycosyl hydrolase 3 family
C0L89_RS09515	COG3706	GGDEF domain
C0L89_RS09515	COG5001	Diguanylate cyclase
C0L89_RS09515	COG4251	negative regulation of phosphorylation
C0L89_RS09515	COG2203	Gaf domain
C0L89_RS09525	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C0L89_RS09535	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C0L89_RS09550	COG0671	phosphoesterase, PA-phosphatase related
C0L89_RS09570	COG1794	racemase activity, acting on amino acids and derivatives
C0L89_RS09580	COG0697	spore germination
C0L89_RS09585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0L89_RS09610	COG1012	belongs to the aldehyde dehydrogenase family
C0L89_RS09670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0L89_RS09685	COG0124	histidyl-tRNA synthetase
C0L89_RS09710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0L89_RS09725	COG0131	Imidazoleglycerol-phosphate dehydratase
C0L89_RS09725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C0L89_RS09735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0L89_RS09745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0L89_RS09745	COG0140	phosphoribosyl-ATP diphosphatase activity
C0L89_RS09770	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C0L89_RS09775	COG0235	Class ii aldolase
C0L89_RS09780	COG0531	amino acid
C0L89_RS09785	COG0531	amino acid
C0L89_RS09795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0L89_RS09800	COG0277	FAD linked oxidase domain protein
C0L89_RS09825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0L89_RS09875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0L89_RS09880	COG2258	MOSC domain
C0L89_RS09885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0L89_RS09890	COG0505	Belongs to the CarA family
C0L89_RS09900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0L89_RS09905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0L89_RS09915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C0L89_RS09930	COG3279	Response regulator of the LytR AlgR family
C0L89_RS09955	COG2205	protein histidine kinase activity
C0L89_RS09955	COG2198	Histidine kinase
C0L89_RS09955	COG0784	Response regulator, receiver
C0L89_RS09960	COG1024	Enoyl-CoA hydratase
C0L89_RS09965	COG0318	PFAM AMP-dependent synthetase and ligase
C0L89_RS09995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0L89_RS10025	COG0840	transmembrane signaling receptor activity
C0L89_RS10035	COG0835	chemotaxis
C0L89_RS10050	COG0840	transmembrane signaling receptor activity
C0L89_RS10055	COG0840	transmembrane signaling receptor activity
C0L89_RS10060	COG0840	transmembrane signaling receptor activity
C0L89_RS10075	COG0840	transmembrane signaling receptor activity
C0L89_RS10085	COG0840	transmembrane signaling receptor activity
C0L89_RS10090	COG0840	transmembrane signaling receptor activity
C0L89_RS10120	COG0840	transmembrane signaling receptor activity
C0L89_RS10125	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS10145	COG0745	RESPONSE REGULATOR receiver
C0L89_RS10155	COG0835	chemotaxis
C0L89_RS10160	COG1192	Involved in chromosome partitioning
C0L89_RS10165	COG1360	Flagellar Motor Protein
C0L89_RS10170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0L89_RS10190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0L89_RS10230	COG3039	Transposase
C0L89_RS10295	COG0784	Response regulator, receiver
C0L89_RS10295	COG0643	Histidine kinase
C0L89_RS10295	COG2198	Histidine kinase
C0L89_RS10350	COG1684	flagellar biosynthetic protein fliR
C0L89_RS10365	COG3190	flagellar
C0L89_RS10415	COG1677	Flagellar hook-basal body complex protein FliE
C0L89_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS10460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0L89_RS10480	COG2201	protein-glutamate methylesterase activity
C0L89_RS10510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C0L89_RS10515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0L89_RS10530	COG1705	Flagellar rod assembly protein muramidase FlgJ
C0L89_RS10530	COG3951	Flagellar rod assembly protein muramidase FlgJ
C0L89_RS10535	COG1706	bacterial-type flagellum-dependent cell motility
C0L89_RS10540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C0L89_RS10555	COG4787	bacterial-type flagellum-dependent cell motility
C0L89_RS10565	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C0L89_RS10570	COG1558	bacterial-type flagellum-dependent cell motility
C0L89_RS10580	COG0835	chemotaxis
C0L89_RS10580	COG0784	Response regulator, receiver
C0L89_RS10600	COG5002	protein histidine kinase activity
C0L89_RS10610	COG4585	Histidine kinase
C0L89_RS10645	COG0482	sulfurtransferase activity
C0L89_RS10660	COG0542	response to heat
C0L89_RS10685	COG0492	ferredoxin-NADP+ reductase activity
C0L89_RS10690	COG1674	ftsk spoiiie
C0L89_RS10715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0L89_RS10735	COG0038	chloride channel
C0L89_RS10740	COG0183	Belongs to the thiolase family
C0L89_RS10745	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0L89_RS10745	COG1024	Enoyl-CoA hydratase
C0L89_RS10760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0L89_RS10780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0L89_RS10785	COG1160	GTP binding
C0L89_RS10790	COG0303	'Molybdopterin
C0L89_RS10800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0L89_RS10810	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS10820	COG3039	Transposase
C0L89_RS10845	COG0746	molybdenum cofactor guanylyltransferase activity
C0L89_RS10870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0L89_RS10870	COG1648	precorrin-2 dehydrogenase activity
C0L89_RS10910	COG3039	Transposase
C0L89_RS10935	COG5001	Diguanylate cyclase
C0L89_RS10945	COG4566	intracellular signal transduction
C0L89_RS11000	COG2201	protein-glutamate methylesterase activity
C0L89_RS11080	COG1024	Enoyl-CoA hydratase
C0L89_RS11085	COG1024	Enoyl-CoA hydratase
C0L89_RS11095	COG1024	Enoyl-CoA hydratase
C0L89_RS11110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0L89_RS11125	COG3039	Transposase
C0L89_RS11140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0L89_RS11145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0L89_RS11195	COG1858	cytochrome C peroxidase
C0L89_RS11230	COG0631	protein serine/threonine phosphatase activity
C0L89_RS11295	COG3039	Transposase
C0L89_RS11380	COG3039	Transposase
C0L89_RS11395	COG2154	pterin-4-alpha-carbinolamine dehydratase
C0L89_RS11410	COG3064	Membrane
C0L89_RS11420	COG1530	ribonuclease E activity
C0L89_RS11435	COG1054	Belongs to the UPF0176 family
C0L89_RS11455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C0L89_RS11495	COG0322	excinuclease ABC activity
C0L89_RS11505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0L89_RS11515	COG1663	tetraacyldisaccharide 4'-kinase activity
C0L89_RS11530	COG0811	peptide transport
C0L89_RS11555	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0L89_RS11570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0L89_RS11585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C0L89_RS11600	COG0354	folic acid binding
C0L89_RS11615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C0L89_RS11625	COG0363	glucosamine-6-phosphate deaminase activity
C0L89_RS11630	COG0129	dihydroxy-acid dehydratase activity
C0L89_RS11635	COG0800	Aldolase
C0L89_RS11715	COG2205	protein histidine kinase activity
C0L89_RS11715	COG0784	Response regulator, receiver
C0L89_RS11730	COG2183	response to ionizing radiation
C0L89_RS11740	COG0723	plastoquinol--plastocyanin reductase activity
C0L89_RS11740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0L89_RS11755	COG3243	poly(R)-hydroxyalkanoic acid synthase
C0L89_RS11765	COG1183	phosphatidylcholine synthase activity
C0L89_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS11785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0L89_RS11795	COG0668	transmembrane transport
C0L89_RS11815	COG1914	H( )-stimulated, divalent metal cation uptake system
C0L89_RS11845	COG0583	DNA-binding transcription factor activity
C0L89_RS11870	COG0583	DNA-binding transcription factor activity
C0L89_RS11875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0L89_RS11880	COG3002	Belongs to the UPF0753 family
C0L89_RS11885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0L89_RS11885	COG0519	Catalyzes the synthesis of GMP from XMP
C0L89_RS11895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0L89_RS11910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0L89_RS11920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0L89_RS11925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C0L89_RS11935	COG0776	regulation of translation
C0L89_RS11940	COG0539	negative regulation of cytoplasmic translation
C0L89_RS11945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0L89_RS11960	COG2957	Belongs to the agmatine deiminase family
C0L89_RS11970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0L89_RS11995	COG0395	ABC-type sugar transport system, permease component
C0L89_RS12000	COG1175	transmembrane transport
C0L89_RS12030	COG2350	Protein conserved in bacteria
C0L89_RS12035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0L89_RS12040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0L89_RS12045	COG1187	pseudouridine synthase activity
C0L89_RS12065	COG0436	Aminotransferase
C0L89_RS12070	COG4133	protoheme IX ABC transporter activity
C0L89_RS12120	COG1278	Cold shock
C0L89_RS12130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0L89_RS12135	COG4988	ABC transporter
C0L89_RS12145	COG1271	oxidase subunit
C0L89_RS12200	COG0165	Argininosuccinate lyase
C0L89_RS12215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0L89_RS12220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0L89_RS12225	COG0137	argininosuccinate synthase activity
C0L89_RS12230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0L89_RS12245	COG2166	iron-sulfur cluster assembly
C0L89_RS12270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0L89_RS12285	COG4302	ethanolamine ammonia-lyase activity
C0L89_RS12300	COG4677	pectinesterase activity
C0L89_RS12305	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS12330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0L89_RS12335	COG0402	S-adenosylhomocysteine deaminase activity
C0L89_RS12355	COG1509	lysine 2,3-aminomutase activity
C0L89_RS12360	COG5001	Diguanylate cyclase
C0L89_RS12360	COG3300	MHYT domain
C0L89_RS12375	COG0483	inositol monophosphate 1-phosphatase activity
C0L89_RS12380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0L89_RS12405	COG0488	(ABC) transporter
C0L89_RS12410	COG0513	Belongs to the DEAD box helicase family
C0L89_RS12420	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0L89_RS12430	COG0625	glutathione transferase activity
C0L89_RS12440	COG1671	Belongs to the UPF0178 family
C0L89_RS12445	COG4681	YaeQ
C0L89_RS12450	COG2081	HI0933 family
C0L89_RS12455	COG5001	Diguanylate cyclase
C0L89_RS12455	COG1716	ATPase activity
C0L89_RS12460	COG0501	Belongs to the peptidase M48B family
C0L89_RS12470	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS12490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0L89_RS12495	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0L89_RS12500	COG0802	atpase or kinase
C0L89_RS12505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0L89_RS12505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0L89_RS12510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C0L89_RS12530	COG3039	Transposase
C0L89_RS12540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C0L89_RS12590	COG0835	chemotaxis
C0L89_RS12595	COG0840	transmembrane signaling receptor activity
C0L89_RS12625	COG2969	positive regulation of protein catabolic process
C0L89_RS12630	COG0625	glutathione transferase activity
C0L89_RS12635	COG2857	Cytochrome c1
C0L89_RS12640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0L89_RS12645	COG0723	plastoquinol--plastocyanin reductase activity
C0L89_RS12655	COG0741	lytic transglycosylase activity
C0L89_RS12680	COG1702	phosphate starvation-inducible protein PhoH
C0L89_RS12700	COG4535	Mg2 and Co2 transporter CorC
C0L89_RS12715	COG1012	belongs to the aldehyde dehydrogenase family
C0L89_RS12720	COG1177	transmembrane transport
C0L89_RS12725	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0L89_RS12735	COG3842	ATPase activity
C0L89_RS12765	COG3039	Transposase
C0L89_RS12790	COG0174	glutamine synthetase
C0L89_RS12795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0L89_RS12805	COG0477	Major facilitator Superfamily
C0L89_RS12815	COG0243	molybdopterin cofactor binding
C0L89_RS12825	COG2223	nitrite transmembrane transporter activity
C0L89_RS12835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0L89_RS12840	COG1121	(ABC) transporter
C0L89_RS12850	COG2733	membrane
C0L89_RS12855	COG5002	protein histidine kinase activity
C0L89_RS12855	COG0784	Response regulator, receiver
C0L89_RS12855	COG2205	protein histidine kinase activity
C0L89_RS12865	COG3039	Transposase
C0L89_RS12870	COG2902	Dehydrogenase
C0L89_RS12880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0L89_RS12885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0L89_RS12900	COG1609	Transcriptional regulator
C0L89_RS12905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0L89_RS12905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0L89_RS12910	COG1105	Belongs to the carbohydrate kinase PfkB family
C0L89_RS12915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0L89_RS12915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0L89_RS12940	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS12980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0L89_RS12990	COG1862	Preprotein translocase
C0L89_RS12995	COG0343	queuine tRNA-ribosyltransferase activity
C0L89_RS13060	COG0405	Gamma-glutamyltransferase
C0L89_RS13065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0L89_RS13080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0L89_RS13085	COG0742	ribosomal rna small subunit methyltransferase
C0L89_RS13090	COG0326	Molecular chaperone. Has ATPase activity
C0L89_RS13135	COG4206	TonB-dependent receptor
C0L89_RS13185	COG0531	amino acid
C0L89_RS13200	COG0006	proline dipeptidase activity
C0L89_RS13210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0L89_RS13225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0L89_RS13230	COG3938	Belongs to the proline racemase family
C0L89_RS13240	COG0552	protein localization to endoplasmic reticulum
C0L89_RS13255	COG1194	a g-specific adenine glycosylase
C0L89_RS13265	COG0784	Response regulator, receiver
C0L89_RS13265	COG4191	Histidine kinase
C0L89_RS13270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0L89_RS13295	COG3040	lipid binding
C0L89_RS13305	COG1960	acyl-CoA dehydrogenase activity
C0L89_RS13315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0L89_RS13345	COG0438	transferase activity, transferring glycosyl groups
C0L89_RS13355	COG0438	transferase activity, transferring glycosyl groups
C0L89_RS13360	COG0438	transferase activity, transferring glycosyl groups
C0L89_RS13415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0L89_RS13430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0L89_RS13455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C0L89_RS13470	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C0L89_RS13475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0L89_RS13480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0L89_RS13485	COG3115	cell septum assembly
C0L89_RS13505	COG0360	Binds together with S18 to 16S ribosomal RNA
C0L89_RS13510	COG0316	Belongs to the HesB IscA family
C0L89_RS13545	COG0288	reversible hydration of carbon dioxide
C0L89_RS13570	COG3844	kynureninase activity
C0L89_RS13580	COG2925	Exonuclease
C0L89_RS13590	COG0667	Aldo Keto reductase
C0L89_RS13620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0L89_RS13620	COG0116	Belongs to the methyltransferase superfamily
C0L89_RS13665	COG0494	nUDIX hydrolase
C0L89_RS13675	COG1024	Enoyl-CoA hydratase
C0L89_RS13685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0L89_RS13690	COG0659	secondary active sulfate transmembrane transporter activity
C0L89_RS13715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C0L89_RS13720	COG0573	inorganic phosphate transmembrane transporter activity
C0L89_RS13735	COG0704	Plays a role in the regulation of phosphate uptake
C0L89_RS13745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0L89_RS13755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0L89_RS13770	COG0557	exoribonuclease II activity
C0L89_RS13800	COG1960	acyl-CoA dehydrogenase activity
C0L89_RS13805	COG2226	methyltransferase
C0L89_RS13810	COG0646	methionine synthase
C0L89_RS13810	COG1410	methionine synthase
C0L89_RS13815	COG0646	methionine synthase
C0L89_RS13815	COG1410	methionine synthase
C0L89_RS13825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0L89_RS13835	COG1609	Transcriptional regulator
C0L89_RS13850	COG2900	Belongs to the SlyX family
C0L89_RS13865	COG0386	Belongs to the glutathione peroxidase family
C0L89_RS13875	COG1725	Transcriptional regulator
C0L89_RS13880	COG1131	(ABC) transporter
C0L89_RS13920	COG3039	Transposase
C0L89_RS13950	COG2850	peptidyl-arginine hydroxylation
C0L89_RS13985	COG1132	(ABC) transporter
C0L89_RS14015	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C0L89_RS14025	COG0484	heat shock protein binding
C0L89_RS14030	COG0443	Heat shock 70 kDa protein
C0L89_RS14035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0L89_RS14045	COG0497	DNA recombination
C0L89_RS14055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0L89_RS14065	COG2914	Belongs to the UPF0125 (RnfH) family
C0L89_RS14075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0L89_RS14100	COG3039	Transposase
C0L89_RS14140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0L89_RS14155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C0L89_RS14165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C0L89_RS14170	COG0174	glutamine synthetase
C0L89_RS14250	COG0415	Belongs to the DNA photolyase family
C0L89_RS14255	COG0305	Participates in initiation and elongation during chromosome replication
C0L89_RS14265	COG0367	asparagine synthase
C0L89_RS14295	COG0084	hydrolase, TatD family'
C0L89_RS14300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C0L89_RS14340	COG0840	transmembrane signaling receptor activity
C0L89_RS14355	COG3039	Transposase
C0L89_RS14370	COG3039	Transposase
C0L89_RS14405	COG0386	Belongs to the glutathione peroxidase family
C0L89_RS14505	COG2814	Major facilitator Superfamily
C0L89_RS14510	COG1566	PFAM secretion protein HlyD family protein
C0L89_RS14525	COG2207	Transcriptional regulator
C0L89_RS14555	COG4774	siderophore transport
C0L89_RS14565	COG0367	asparagine synthase
C0L89_RS14580	COG1393	Belongs to the ArsC family
C0L89_RS14640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0L89_RS14655	COG0233	cytoplasmic translational termination
C0L89_RS14665	COG0575	Belongs to the CDS family
C0L89_RS14670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0L89_RS14675	COG0750	zinc metalloprotease
C0L89_RS14695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0L89_RS14700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0L89_RS14720	COG0825	malonyl-CoA metabolic process
C0L89_RS14745	COG1981	membrane
C0L89_RS14795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C0L89_RS14810	COG2040	homocysteine
C0L89_RS14815	COG0833	amino acid
C0L89_RS14820	COG0346	lactoylglutathione lyase activity
C0L89_RS14830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0L89_RS14830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0L89_RS14840	COG2878	Part of a membrane complex involved in electron transport
C0L89_RS14860	COG1595	DNA-templated transcription, initiation
C0L89_RS14885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0L89_RS14900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0L89_RS14905	COG0251	oxidation-reduction process
C0L89_RS14915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0L89_RS14915	COG0392	lysyltransferase activity
C0L89_RS14955	COG2814	Major facilitator Superfamily
C0L89_RS14960	COG1902	pentaerythritol trinitrate reductase activity
C0L89_RS14975	COG2824	Alkylphosphonate utilization operon protein PhnA
C0L89_RS14985	COG1047	Peptidyl-prolyl cis-trans
C0L89_RS15025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0L89_RS15040	COG1451	nucleotide metabolic process
C0L89_RS15060	COG0183	Belongs to the thiolase family
C0L89_RS15090	COG1793	dna ligase
C0L89_RS15090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C0L89_RS15100	COG1793	dna ligase
C0L89_RS15105	COG1201	RNA secondary structure unwinding
C0L89_RS15125	COG1278	Cold shock
C0L89_RS15130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C0L89_RS15145	COG3046	protein related to deoxyribodipyrimidine photolyase
C0L89_RS15150	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C0L89_RS15160	COG2954	triphosphatase activity
C0L89_RS15175	COG1381	Involved in DNA repair and RecF pathway recombination
C0L89_RS15205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0L89_RS15220	COG1024	Enoyl-CoA hydratase
C0L89_RS15220	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0L89_RS15240	COG1024	Enoyl-CoA hydratase
C0L89_RS15245	COG1960	acyl-CoA dehydrogenase activity
C0L89_RS15320	COG2353	YceI-like domain
C0L89_RS15345	COG1760	l-serine dehydratase
C0L89_RS15355	COG0626	cystathionine gamma-synthase activity
C0L89_RS15360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0L89_RS15365	COG0739	heme binding
C0L89_RS15375	COG1272	protein, Hemolysin III
C0L89_RS15395	COG0517	IMP dehydrogenase activity
C0L89_RS15395	COG0516	GMP reductase activity
C0L89_RS15400	COG0463	Glycosyl transferase, family 2
C0L89_RS15410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0L89_RS15420	COG4771	TonB-dependent receptor
C0L89_RS15425	COG1309	transcriptional regulator
C0L89_RS15435	COG1960	acyl-CoA dehydrogenase activity
C0L89_RS15465	COG0509	glycine decarboxylation via glycine cleavage system
C0L89_RS15480	COG0330	HflC and HflK could
C0L89_RS15490	COG1742	UPF0060 membrane protein
C0L89_RS15495	COG3956	TIGRFAM MazG family protein
C0L89_RS15505	COG0494	nUDIX hydrolase
C0L89_RS15515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0L89_RS15520	COG0837	glucose binding
C0L89_RS15535	COG1388	LysM domain
C0L89_RS15535	COG3858	chitin binding
C0L89_RS15555	COG1472	Belongs to the glycosyl hydrolase 3 family
C0L89_RS15590	COG3537	Alpha-1,2-mannosidase
C0L89_RS15635	COG3142	Participates in the control of copper homeostasis
C0L89_RS15640	COG1446	asparaginase
C0L89_RS15650	COG2304	oxidoreductase activity
C0L89_RS15675	COG0643	Histidine kinase
C0L89_RS15675	COG2198	Histidine kinase
C0L89_RS15675	COG0784	Response regulator, receiver
C0L89_RS15680	COG0840	transmembrane signaling receptor activity
C0L89_RS15685	COG0835	chemotaxis
C0L89_RS15700	COG0189	ligase activity
C0L89_RS15710	COG1397	ADP-ribosylglycohydrolase
C0L89_RS15720	COG1199	ATP-dependent helicase activity
C0L89_RS15730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0L89_RS15735	COG1215	transferase activity, transferring glycosyl groups
C0L89_RS15745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0L89_RS15795	COG1643	Atp-dependent helicase
C0L89_RS15800	COG0783	Belongs to the Dps family
C0L89_RS15815	COG0514	ATP-dependent DNA helicase (RecQ)
C0L89_RS15830	COG3039	Transposase
C0L89_RS15845	COG1187	pseudouridine synthase activity
C0L89_RS15895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0L89_RS15905	COG0602	queuosine metabolic process
C0L89_RS15915	COG2885	chlorophyll binding
C0L89_RS15920	COG0823	Involved in the tonB-independent uptake of proteins
C0L89_RS15930	COG0848	biopolymer transport protein
C0L89_RS15940	COG0824	Thioesterase
C0L89_RS15945	COG2255	four-way junction helicase activity
C0L89_RS15960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0L89_RS15980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0L89_RS15995	COG0477	Major facilitator Superfamily
C0L89_RS16030	COG0488	(ABC) transporter
C0L89_RS16060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0L89_RS16060	COG4651	solute:proton antiporter activity
C0L89_RS16105	COG4772	TonB-dependent receptor
C0L89_RS16115	COG4264	IucA IucC family
C0L89_RS16130	COG0019	diaminopimelate decarboxylase activity
C0L89_RS16185	COG4206	TonB-dependent receptor
C0L89_RS16215	COG0542	response to heat
C0L89_RS16240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C0L89_RS16250	COG0534	Mate efflux family protein
C0L89_RS16265	COG0336	Belongs to the RNA methyltransferase TrmD family
C0L89_RS16270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0L89_RS16275	COG0228	four-way junction DNA binding
C0L89_RS16300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0L89_RS16305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0L89_RS16345	COG2172	sigma factor antagonist activity
C0L89_RS16350	COG1366	Belongs to the anti-sigma-factor antagonist family
C0L89_RS16355	COG1366	Belongs to the anti-sigma-factor antagonist family
C0L89_RS16365	COG0326	Molecular chaperone. Has ATPase activity
C0L89_RS16370	COG2207	Transcriptional regulator
C0L89_RS16410	COG3209	COG3209 Rhs family protein
C0L89_RS16430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C0L89_RS16435	COG1845	cytochrome c oxidase, subunit III
C0L89_RS16440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0L89_RS16455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0L89_RS16460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0L89_RS16475	COG0728	peptidoglycan biosynthetic process
C0L89_RS16480	COG0268	Binds directly to 16S ribosomal RNA
C0L89_RS16485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0L89_RS16490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0L89_RS16500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0L89_RS16505	COG0824	Thioesterase
C0L89_RS16520	COG1946	Acyl-CoA thioesterase
C0L89_RS16530	COG1595	DNA-templated transcription, initiation
C0L89_RS16545	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C0L89_RS16585	COG1877	trehalose-phosphatase activity
C0L89_RS16590	COG3387	PFAM Glycoside hydrolase 15-related
C0L89_RS16630	COG0564	pseudouridine synthase activity
C0L89_RS16635	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0L89_RS16640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0L89_RS16640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0L89_RS16655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0L89_RS16660	COG0045	succinate-CoA ligase (ADP-forming) activity
C0L89_RS16700	COG2194	sulfuric ester hydrolase activity
C0L89_RS16705	COG4969	Belongs to the N-Me-Phe pilin family
C0L89_RS16715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C0L89_RS16720	COG0237	dephospho-CoA kinase activity
C0L89_RS16725	COG2205	protein histidine kinase activity
C0L89_RS16730	COG0745	RESPONSE REGULATOR receiver
C0L89_RS16750	COG3039	Transposase
C0L89_RS16765	COG3039	Transposase
C0L89_RS16795	COG3039	Transposase
C0L89_RS16820	COG2022	thiamine diphosphate biosynthetic process
C0L89_RS16835	COG0471	metal ion transport
C0L89_RS16835	COG3273	potassium ion transport
C0L89_RS16865	COG1970	mechanosensitive ion channel activity
C0L89_RS16900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0L89_RS16915	COG0308	aminopeptidase N
C0L89_RS16920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0L89_RS16930	COG0529	Catalyzes the synthesis of activated sulfate
C0L89_RS16930	COG2895	sulfate adenylyltransferase (ATP) activity
C0L89_RS16935	COG0175	sulfate reduction
C0L89_RS16940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C0L89_RS16945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0L89_RS16950	COG0175	sulfate reduction
C0L89_RS16970	COG2198	Histidine kinase
C0L89_RS16970	COG0784	Response regulator, receiver
C0L89_RS16970	COG2205	protein histidine kinase activity
C0L89_RS17015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C0L89_RS17020	COG3588	fructose-bisphosphate aldolase
C0L89_RS17030	COG0469	pyruvate kinase activity
C0L89_RS17055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0L89_RS17070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0L89_RS17070	COG3453	Protein conserved in bacteria
C0L89_RS17075	COG0725	ABC transporter, periplasmic molybdate-binding protein
C0L89_RS17080	COG4149	molybdate abc transporter
C0L89_RS17085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C0L89_RS17105	COG0642	Histidine kinase
C0L89_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS17130	COG1022	Amp-dependent synthetase and ligase
C0L89_RS17160	COG1376	ErfK ybiS ycfS ynhG family protein
C0L89_RS17165	COG0739	heme binding
C0L89_RS17180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0L89_RS17185	COG1301	dicarboxylic acid transport
C0L89_RS17205	COG2304	oxidoreductase activity
C0L89_RS17225	COG0714	Associated with various cellular activities
C0L89_RS17260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C0L89_RS17295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0L89_RS17305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0L89_RS17325	COG1561	YicC-like family, N-terminal region
C0L89_RS17330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0L89_RS17345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0L89_RS17375	COG0006	proline dipeptidase activity
C0L89_RS17400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0L89_RS17420	COG2912	Transglutaminase-like superfamily
C0L89_RS17425	COG1773	rubredoxin
C0L89_RS17430	COG0352	thiamine-phosphate diphosphorylase activity
C0L89_RS17445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0L89_RS17460	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C0L89_RS17500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0L89_RS17525	COG0671	phosphoesterase, PA-phosphatase related
C0L89_RS17540	COG3781	membrane
C0L89_RS17550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0L89_RS17565	COG3039	Transposase
C0L89_RS17580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C0L89_RS17590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0L89_RS17615	COG3710	Transcriptional regulator
C0L89_RS17620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0L89_RS17630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0L89_RS17660	COG2226	methyltransferase
C0L89_RS17665	COG0066	3-isopropylmalate dehydratase activity
C0L89_RS17670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0L89_RS17690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0L89_RS17695	COG1538	Outer membrane efflux protein
C0L89_RS17700	COG1519	Transferase
C0L89_RS17705	COG1560	Kdo2-lipid A biosynthetic process
C0L89_RS17735	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS17775	COG0280	phosphate acetyltransferase
C0L89_RS17775	COG0281	malic enzyme
C0L89_RS17795	COG4191	Histidine kinase
C0L89_RS17810	COG0583	DNA-binding transcription factor activity
C0L89_RS17830	COG2197	response regulator
C0L89_RS17840	COG0642	Histidine kinase
C0L89_RS17860	COG2851	Citrate transporter
C0L89_RS17865	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS17875	COG1609	Transcriptional regulator
C0L89_RS17880	COG2211	Major facilitator Superfamily
C0L89_RS17910	COG0436	Aminotransferase
C0L89_RS17935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0L89_RS17955	COG0402	S-adenosylhomocysteine deaminase activity
C0L89_RS18005	COG0242	peptide deformylase activity
C0L89_RS18010	COG3039	Transposase
C0L89_RS18040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C0L89_RS18100	COG2188	Transcriptional regulator
C0L89_RS18115	COG1450	Type ii and iii secretion system protein
C0L89_RS18130	COG3166	PFAM Fimbrial assembly family protein
C0L89_RS18135	COG3156	type II secretion system protein K
C0L89_RS18140	COG4795	General secretion pathway protein
C0L89_RS18145	COG2165	general secretion pathway protein
C0L89_RS18150	COG4970	Tfp pilus assembly protein FimT
C0L89_RS18155	COG2165	general secretion pathway protein
C0L89_RS18160	COG1459	type II secretion system
C0L89_RS18170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0L89_RS18175	COG1404	Belongs to the peptidase S8 family
C0L89_RS18180	COG5295	Hep Hag repeat protein
C0L89_RS18190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0L89_RS18190	COG0047	phosphoribosylformylglycinamidine synthase activity
C0L89_RS18200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0L89_RS18205	COG4974	Belongs to the 'phage' integrase family
C0L89_RS18220	COG0795	lipopolysaccharide-transporting ATPase activity
C0L89_RS18230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0L89_RS18255	COG0525	valine-tRNA ligase activity
C0L89_RS18295	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS18305	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS18330	COG1183	phosphatidylcholine synthase activity
C0L89_RS18340	COG0442	prolyl-tRNA aminoacylation
C0L89_RS18355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0L89_RS18360	COG1127	ABC transporter
C0L89_RS18365	COG3218	ABC-type transport auxiliary lipoprotein component
C0L89_RS18365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0L89_RS18410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0L89_RS18415	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C0L89_RS18415	COG0662	Cupin 2, conserved barrel domain protein
C0L89_RS18445	COG2086	electron transfer activity
C0L89_RS18505	COG0626	cystathionine gamma-synthase activity
C0L89_RS18535	COG0625	glutathione transferase activity
C0L89_RS18550	COG0513	Belongs to the DEAD box helicase family
C0L89_RS18560	COG0720	synthase
C0L89_RS18570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0L89_RS18575	COG1956	GAF domain-containing protein
C0L89_RS18585	COG3039	Transposase
C0L89_RS18590	COG0546	phosphoglycolate phosphatase activity
C0L89_RS18620	COG0339	signal peptide processing
C0L89_RS18670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0L89_RS18735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0L89_RS18740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0L89_RS18745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0L89_RS18755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0L89_RS18765	COG0356	it plays a direct role in the translocation of protons across the membrane
C0L89_RS18785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0L89_RS18795	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0L89_RS18830	COG2011	ABC-type metal ion transport system permease component
C0L89_RS18840	COG0697	spore germination
C0L89_RS18875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0L89_RS18880	COG1187	pseudouridine synthase activity
C0L89_RS18885	COG2813	Specifically methylates the guanine in position
C0L89_RS18915	COG2205	protein histidine kinase activity
C0L89_RS18915	COG2202	Pas domain
C0L89_RS18940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0L89_RS18990	COG0745	RESPONSE REGULATOR receiver
C0L89_RS19005	COG1404	Belongs to the peptidase S8 family
C0L89_RS19020	COG0842	Transport permease protein
C0L89_RS19025	COG1131	(ABC) transporter
C0L89_RS19030	COG0025	NhaP-type Na H and K H
C0L89_RS19040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C0L89_RS19050	COG1573	uracil-dna glycosylase
C0L89_RS19060	COG3384	dioxygenase
C0L89_RS19075	COG0667	Aldo Keto reductase
C0L89_RS19090	COG3590	peptidase
C0L89_RS19110	COG0531	amino acid
C0L89_RS19135	COG3685	Protein conserved in bacteria
C0L89_RS19140	COG3546	catalase activity
C0L89_RS19165	COG3039	Transposase
C0L89_RS19195	COG1271	oxidase subunit
C0L89_RS19200	COG1294	oxidase, subunit
C0L89_RS19235	COG1063	alcohol dehydrogenase
C0L89_RS19330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0L89_RS19330	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0L89_RS19340	COG1473	amidohydrolase
C0L89_RS19345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0L89_RS19350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0L89_RS19375	COG5383	Protein conserved in bacteria
C0L89_RS19425	COG3023	N-Acetylmuramoyl-L-alanine amidase
C0L89_RS19435	COG4948	Mandelate Racemase Muconate Lactonizing
C0L89_RS19460	COG0531	amino acid
C0L89_RS19480	COG4682	membrane
C0L89_RS19485	COG2133	pyrroloquinoline quinone binding
C0L89_RS19505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0L89_RS19510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0L89_RS19525	COG1610	YqeY-like protein
C0L89_RS19545	COG1295	ribonuclease BN
C0L89_RS19550	COG0358	DNA primase activity
C0L89_RS19620	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C0L89_RS19635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0L89_RS19700	COG0739	heme binding
C0L89_RS19715	COG2211	Major facilitator Superfamily
C0L89_RS19720	COG0708	Exodeoxyribonuclease III
C0L89_RS19850	COG0740	serine-type endopeptidase activity
C0L89_RS19855	COG4695	Portal protein
C0L89_RS19860	COG1802	Transcriptional regulator
C0L89_RS19860	COG4626	Terminase
C0L89_RS19965	COG0582	viral genome integration into host DNA
C0L89_RS19980	COG1192	Involved in chromosome partitioning
C0L89_RS19985	COG1475	DNA binding
C0L89_RS20000	COG0463	Glycosyl transferase, family 2
C0L89_RS20025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0L89_RS20050	COG4221	oxidoreductase activity
C0L89_RS20090	COG1166	arginine decarboxylase activity
C0L89_RS20095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0L89_RS20140	COG0606	chelatase, subunit chli
C0L89_RS20165	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C0L89_RS20185	COG3039	Transposase
C0L89_RS20245	COG1090	epimerase
C0L89_RS20255	COG0642	Histidine kinase
C0L89_RS20270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0L89_RS20305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0L89_RS20315	COG1595	DNA-templated transcription, initiation
C0L89_RS20320	COG0753	catalase activity
C0L89_RS20345	COG0697	spore germination
C0L89_RS20370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0L89_RS20375	COG0180	Tryptophanyl-tRNA synthetase
C0L89_RS20380	COG3237	CsbD-like
C0L89_RS20395	COG0010	Belongs to the arginase family
C0L89_RS20415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0L89_RS20430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C0L89_RS20435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C0L89_RS20435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C0L89_RS20445	COG3228	Belongs to the MtfA family
C0L89_RS20475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0L89_RS20530	COG3039	Transposase
C0L89_RS20535	COG1566	PFAM secretion protein HlyD family protein
C0L89_RS20550	COG1199	ATP-dependent helicase activity
C0L89_RS20595	COG0583	DNA-binding transcription factor activity
C0L89_RS20655	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS20685	COG4555	ABC transporter
C0L89_RS20695	COG1476	TRANSCRIPTIONal
C0L89_RS20715	COG1230	cation diffusion facilitator family transporter
C0L89_RS20720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C0L89_RS20725	COG1131	(ABC) transporter
C0L89_RS20730	COG0842	Transport permease protein
C0L89_RS20740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0L89_RS20795	COG2951	lytic endotransglycosylase activity
C0L89_RS20815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0L89_RS20825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0L89_RS20840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0L89_RS20840	COG0045	succinate-CoA ligase (ADP-forming) activity
C0L89_RS20840	COG1042	CoA-binding domain protein
C0L89_RS20850	COG2239	Acts as a magnesium transporter
C0L89_RS20875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C0L89_RS20880	COG3387	PFAM Glycoside hydrolase 15-related
C0L89_RS20895	COG3100	YcgL domain-containing protein
C0L89_RS20900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0L89_RS20910	COG0463	Glycosyl transferase, family 2
C0L89_RS20925	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS20955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0L89_RS20970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0L89_RS21010	COG0408	coproporphyrinogen oxidase activity
C0L89_RS21085	COG0210	DNA helicase
C0L89_RS21105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0L89_RS21120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0L89_RS21135	COG2159	amidohydrolase
C0L89_RS21165	COG0357	Ribosomal RNA small subunit methyltransferase G
C0L89_RS21170	COG3540	Alkaline phosphatase
C0L89_RS21180	COG2091	lysine biosynthetic process via aminoadipic acid
C0L89_RS21195	COG0708	Exodeoxyribonuclease III
C0L89_RS21210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0L89_RS21215	COG3162	membrane
C0L89_RS21270	COG1028	Short-chain dehydrogenase reductase Sdr
C0L89_RS21275	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0L89_RS21285	COG4948	Mandelate Racemase Muconate Lactonizing
C0L89_RS21295	COG3039	Transposase
C0L89_RS21300	COG3254	rhamnose metabolic process
C0L89_RS21305	COG0738	Major facilitator superfamily
C0L89_RS21310	COG1414	Transcriptional regulator
C0L89_RS21320	COG2205	protein histidine kinase activity
C0L89_RS21330	COG3459	Glycosyltransferase 36 associated
C0L89_RS21335	COG2211	Major facilitator Superfamily
C0L89_RS21340	COG3265	gluconokinase activity
C0L89_RS21345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0L89_RS21380	COG3039	Transposase
C0L89_RS21390	COG3039	Transposase
C0L89_RS21395	COG2911	Protein conserved in bacteria
C0L89_RS21400	COG0729	surface antigen
C0L89_RS21405	COG4771	TonB-dependent receptor
C0L89_RS21410	COG0457	Tetratricopeptide repeat
C0L89_RS21420	COG0752	glycyl-tRNA synthetase alpha subunit
C0L89_RS21425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0L89_RS21435	COG0519	Catalyzes the synthesis of GMP from XMP
C0L89_RS21435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0L89_RS21445	COG0805	protein transport
C0L89_RS21450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0L89_RS21455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0L89_RS21465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0L89_RS21495	COG2974	May be involved in recombination
C0L89_RS21500	COG0037	tRNA processing
C0L89_RS21525	COG3661	Belongs to the glycosyl hydrolase 67 family
C0L89_RS21535	COG4948	Mandelate Racemase Muconate Lactonizing
C0L89_RS21555	COG0246	Mannitol dehydrogenase
C0L89_RS21590	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS21620	COG3693	PFAM glycoside hydrolase, family 10
C0L89_RS21645	COG2211	Major facilitator Superfamily
C0L89_RS21660	COG3039	Transposase
C0L89_RS21695	COG2937	Belongs to the GPAT DAPAT family
C0L89_RS21740	COG0284	orotidine-5'-phosphate decarboxylase activity
C0L89_RS21745	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C0L89_RS21750	COG3132	Protein of unknown function, DUF480
C0L89_RS21765	COG0210	DNA helicase
C0L89_RS21780	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C0L89_RS21790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0L89_RS21845	COG0676	glucose-6-phosphate 1-epimerase activity
C0L89_RS21860	COG0730	response to heat
C0L89_RS21895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0L89_RS21900	COG0302	gtp cyclohydrolase
C0L89_RS21930	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS21940	COG0477	Major facilitator Superfamily
C0L89_RS21955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0L89_RS22000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0L89_RS22060	COG3237	CsbD-like
C0L89_RS22095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0L89_RS22125	COG1304	FMN binding
C0L89_RS22150	COG4772	TonB-dependent receptor
C0L89_RS22160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C0L89_RS22195	COG3039	Transposase
C0L89_RS22250	COG0564	pseudouridine synthase activity
C0L89_RS22265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0L89_RS22305	COG3039	Transposase
C0L89_RS22325	COG2826	transposase and inactivated derivatives, IS30 family
C0L89_RS22390	COG1074	ATP-dependent DNA helicase activity
C0L89_RS22395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C0L89_RS22410	COG3039	Transposase
C0L89_RS22415	COG3039	Transposase
C0L89_RS22425	COG1136	(ABC) transporter
C0L89_RS22445	COG1127	ABC transporter
C0L89_RS22450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0L89_RS22455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0L89_RS22470	COG2853	Lipoprotein
C0L89_RS22485	COG0386	Belongs to the glutathione peroxidase family
C0L89_RS22495	COG1322	Protein conserved in bacteria
C0L89_RS22500	COG3039	Transposase
C0L89_RS22525	COG1929	Belongs to the glycerate kinase type-1 family
C0L89_RS22530	COG2271	Major facilitator Superfamily
C0L89_RS22545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0L89_RS22555	COG0861	Integral membrane protein TerC family
C0L89_RS22570	COG0584	glycerophosphoryl diester phosphodiesterase
C0L89_RS22580	COG0671	phosphoesterase, PA-phosphatase related
C0L89_RS22585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0L89_RS22590	COG0726	polysaccharide deacetylase