locus-tag	class	description
BVV18_RS00025	COG0187	DNA topoisomerase II activity
BVV18_RS00035	COG0501	Belongs to the peptidase M48B family
BVV18_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BVV18_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BVV18_RS00095	COG3039	Transposase
BVV18_RS00145	COG0793	Belongs to the peptidase S41A family
BVV18_RS00150	COG4942	peptidase
BVV18_RS00160	COG2234	aminopeptidase activity
BVV18_RS00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BVV18_RS00185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BVV18_RS00195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BVV18_RS00205	COG1064	alcohol dehydrogenase
BVV18_RS00235	COG0493	'glutamate synthase
BVV18_RS00240	COG0067	glutamate synthase
BVV18_RS00240	COG0070	glutamate synthase
BVV18_RS00240	COG0069	glutamate synthase activity
BVV18_RS00310	COG1205	dead DEAH box helicase
BVV18_RS00310	COG1111	helicase
BVV18_RS00315	COG1272	protein, Hemolysin III
BVV18_RS00345	COG2032	superoxide dismutase activity
BVV18_RS00350	COG2204	response regulator
BVV18_RS00355	COG3852	Histidine kinase
BVV18_RS00360	COG0004	ammonium transporteR
BVV18_RS00365	COG0347	Belongs to the P(II) protein family
BVV18_RS00370	COG0174	glutamine synthetase
BVV18_RS00375	COG1968	undecaprenyl-diphosphatase activity
BVV18_RS00425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BVV18_RS00435	COG2062	phosphohistidine phosphatase, SixA
BVV18_RS00440	COG0489	protein tyrosine kinase activity
BVV18_RS00460	COG1396	sequence-specific DNA binding
BVV18_RS00465	COG3550	peptidyl-serine autophosphorylation
BVV18_RS00470	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BVV18_RS00475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BVV18_RS00490	COG1125	glycine betaine transport
BVV18_RS00505	COG1119	ATPase activity
BVV18_RS00520	COG1752	Esterase of the alpha-beta hydrolase superfamily
BVV18_RS00530	COG1522	sequence-specific DNA binding
BVV18_RS00535	COG3186	Phenylalanine-4-hydroxylase
BVV18_RS00565	COG1609	Transcriptional regulator
BVV18_RS00610	COG0366	Alpha amylase catalytic
BVV18_RS00615	COG0366	Alpha amylase catalytic
BVV18_RS00625	COG3039	Transposase
BVV18_RS00675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BVV18_RS00680	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BVV18_RS00695	COG0028	Belongs to the TPP enzyme family
BVV18_RS00700	COG4191	Histidine kinase
BVV18_RS00725	COG3039	Transposase
BVV18_RS00735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BVV18_RS00750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BVV18_RS00755	COG3177	Filamentation induced by cAMP protein fic
BVV18_RS00760	COG0596	Alpha beta hydrolase
BVV18_RS00770	COG0727	PFAM Uncharacterised protein family (UPF0153)
BVV18_RS00775	COG0318	PFAM AMP-dependent synthetase and ligase
BVV18_RS00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BVV18_RS00795	COG1181	Belongs to the D-alanine--D-alanine ligase family
BVV18_RS00810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BVV18_RS00825	COG0564	pseudouridine synthase activity
BVV18_RS00855	COG0339	signal peptide processing
BVV18_RS00900	COG4770	biotin carboxylase activity
BVV18_RS00910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BVV18_RS00915	COG1960	acyl-CoA dehydrogenase activity
BVV18_RS00960	COG0523	cobalamin synthesis protein
BVV18_RS00970	COG0697	spore germination
BVV18_RS00980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BVV18_RS00985	COG1846	Transcriptional regulator
BVV18_RS00990	COG1764	response to oxidative stress
BVV18_RS01040	COG0656	L-ascorbic acid biosynthetic process
BVV18_RS01055	COG2130	NADP-dependent
BVV18_RS01070	COG1187	pseudouridine synthase activity
BVV18_RS01085	COG1643	Atp-dependent helicase
BVV18_RS01095	COG4807	Protein conserved in bacteria
BVV18_RS01100	COG2072	flavoprotein involved in K transport
BVV18_RS01120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BVV18_RS01125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BVV18_RS01165	COG3039	Transposase
BVV18_RS01210	COG0084	hydrolase, TatD family'
BVV18_RS01230	COG0583	DNA-binding transcription factor activity
BVV18_RS01235	COG2814	Major facilitator Superfamily
BVV18_RS01245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BVV18_RS01250	COG1902	pentaerythritol trinitrate reductase activity
BVV18_RS01280	COG0745	RESPONSE REGULATOR receiver
BVV18_RS01300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BVV18_RS01305	COG0583	DNA-binding transcription factor activity
BVV18_RS01335	COG0702	epimerase
BVV18_RS01340	COG1733	regulation of RNA biosynthetic process
BVV18_RS01375	COG3039	Transposase
BVV18_RS01410	COG0129	dihydroxy-acid dehydratase activity
BVV18_RS01420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BVV18_RS01490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BVV18_RS01505	COG3485	protocatechuate 3,4-dioxygenase
BVV18_RS01510	COG3485	protocatechuate 3,4-dioxygenase
BVV18_RS01525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BVV18_RS01530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BVV18_RS01545	COG1414	Transcriptional regulator
BVV18_RS01585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BVV18_RS01625	COG0156	8-amino-7-oxononanoate synthase activity
BVV18_RS01630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BVV18_RS01635	COG1040	competence protein
BVV18_RS01640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BVV18_RS01750	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BVV18_RS01825	COG3264	Mechanosensitive ion channel
BVV18_RS01825	COG1511	domain protein
BVV18_RS01835	COG3039	Transposase
BVV18_RS01840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BVV18_RS01850	COG2354	Protein conserved in bacteria
BVV18_RS01880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BVV18_RS01905	COG0702	epimerase
BVV18_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS01960	COG0513	Belongs to the DEAD box helicase family
BVV18_RS01970	COG3039	Transposase
BVV18_RS02000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BVV18_RS02010	COG3483	tryptophan 2,3-dioxygenase activity
BVV18_RS02015	COG3104	oligopeptide transport
BVV18_RS02035	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BVV18_RS02045	COG1320	monovalent cation:proton antiporter activity
BVV18_RS02050	COG2212	antiporter activity
BVV18_RS02060	COG0651	ATP synthesis coupled electron transport
BVV18_RS02065	COG1006	Multisubunit Na H antiporter MnhC subunit
BVV18_RS02070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BVV18_RS02070	COG2111	Na H antiporter
BVV18_RS02105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BVV18_RS02115	COG0456	acetyltransferase
BVV18_RS02155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BVV18_RS02160	COG0134	indole-3-glycerol-phosphate synthase activity
BVV18_RS02170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BVV18_RS02175	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BVV18_RS02185	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BVV18_RS02190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BVV18_RS02195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BVV18_RS02265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BVV18_RS02285	COG2814	Major facilitator Superfamily
BVV18_RS02295	COG2814	Major facilitator Superfamily
BVV18_RS02300	COG1289	transmembrane transporter activity
BVV18_RS02310	COG0151	Belongs to the GarS family
BVV18_RS02320	COG0419	ATPase involved in DNA repair
BVV18_RS02325	COG0138	bifunctional purine biosynthesis protein purh
BVV18_RS02330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BVV18_RS02340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BVV18_RS02395	COG0439	Biotin carboxylase
BVV18_RS02405	COG0511	ligase activity, forming carbon-carbon bonds
BVV18_RS02410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BVV18_RS02425	COG1324	tolerance protein
BVV18_RS02445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BVV18_RS02465	COG0534	Mate efflux family protein
BVV18_RS02470	COG0616	signal peptide processing
BVV18_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS02495	COG0009	L-threonylcarbamoyladenylate synthase
BVV18_RS02500	COG1754	DNA topoisomerase type I activity
BVV18_RS02500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BVV18_RS02520	COG0758	DNA mediated transformation
BVV18_RS02525	COG1652	LysM domain
BVV18_RS02530	COG0242	peptide deformylase activity
BVV18_RS02535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BVV18_RS02540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BVV18_RS02540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BVV18_RS02590	COG1560	Kdo2-lipid A biosynthetic process
BVV18_RS02600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BVV18_RS02770	COG3179	chitinase
BVV18_RS02815	COG4695	Portal protein
BVV18_RS02885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BVV18_RS02890	COG3118	belongs to the thioredoxin family
BVV18_RS02900	COG2884	Cell division ATP-binding protein ftsE
BVV18_RS02905	COG2177	Part of the ABC transporter FtsEX involved in
BVV18_RS02910	COG3437	response regulator, receiver
BVV18_RS02915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BVV18_RS02920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BVV18_RS02925	COG2860	membrane
BVV18_RS02930	COG1252	NADH dehydrogenase
BVV18_RS02955	COG0459	protein refolding
BVV18_RS02970	COG3039	Transposase
BVV18_RS02980	COG3039	Transposase
BVV18_RS02990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BVV18_RS03005	COG3386	PFAM SMP-30 Gluconolaconase
BVV18_RS03020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BVV18_RS03075	COG2353	YceI-like domain
BVV18_RS03175	COG4221	oxidoreductase activity
BVV18_RS03230	COG0697	spore germination
BVV18_RS03235	COG4305	rare lipoprotein A
BVV18_RS03240	COG5297	Belongs to the glycosyl hydrolase family 6
BVV18_RS03250	COG1113	amino acid transport
BVV18_RS03260	COG0598	Magnesium transport protein CorA
BVV18_RS03335	COG3300	MHYT domain
BVV18_RS03335	COG5001	Diguanylate cyclase
BVV18_RS03360	COG5297	Belongs to the glycosyl hydrolase family 6
BVV18_RS03360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BVV18_RS03365	COG0659	secondary active sulfate transmembrane transporter activity
BVV18_RS03400	COG3275	phosphorelay sensor kinase activity
BVV18_RS03410	COG0181	hydroxymethylbilane synthase activity
BVV18_RS03435	COG1505	serine-type exopeptidase activity
BVV18_RS03445	COG0436	Aminotransferase
BVV18_RS03455	COG2832	Protein of unknown function (DUF454)
BVV18_RS03470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BVV18_RS03480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BVV18_RS03515	COG5001	Diguanylate cyclase
BVV18_RS03515	COG3300	MHYT domain
BVV18_RS03520	COG0308	aminopeptidase N
BVV18_RS03535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BVV18_RS03540	COG1077	Cell shape determining protein MreB Mrl
BVV18_RS03560	COG0772	Belongs to the SEDS family
BVV18_RS03585	COG2951	lytic endotransglycosylase activity
BVV18_RS03590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BVV18_RS03595	COG1686	Belongs to the peptidase S11 family
BVV18_RS03610	COG2921	Belongs to the UPF0250 family
BVV18_RS03635	COG1056	cytidyltransferase-related domain
BVV18_RS03635	COG1051	belongs to the nudix hydrolase family
BVV18_RS03670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BVV18_RS03675	COG0673	inositol 2-dehydrogenase activity
BVV18_RS03680	COG2823	Periplasmic or secreted lipoprotein
BVV18_RS03685	COG4251	negative regulation of phosphorylation
BVV18_RS03690	COG0784	Response regulator, receiver
BVV18_RS03695	COG4191	Histidine kinase
BVV18_RS03700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BVV18_RS03725	COG3039	Transposase
BVV18_RS03740	COG3250	beta-galactosidase activity
BVV18_RS03755	COG2188	Transcriptional regulator
BVV18_RS03765	COG1609	Transcriptional regulator
BVV18_RS03770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BVV18_RS03775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BVV18_RS03790	COG1215	transferase activity, transferring glycosyl groups
BVV18_RS03795	COG1649	PFAM Uncharacterised BCR, COG1649
BVV18_RS03795	COG0726	polysaccharide deacetylase
BVV18_RS03815	COG3039	Transposase
BVV18_RS03855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BVV18_RS03905	COG2205	protein histidine kinase activity
BVV18_RS03935	COG3791	Glutathione-dependent formaldehyde-activating
BVV18_RS03950	COG3039	Transposase
BVV18_RS03965	COG0488	(ABC) transporter
BVV18_RS03985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BVV18_RS03995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BVV18_RS04005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BVV18_RS04005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BVV18_RS04025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BVV18_RS04030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BVV18_RS04035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BVV18_RS04060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BVV18_RS04065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BVV18_RS04075	COG2205	protein histidine kinase activity
BVV18_RS04080	COG0745	RESPONSE REGULATOR receiver
BVV18_RS04110	COG0277	FAD linked oxidase domain protein
BVV18_RS04120	COG0792	nuclease activity
BVV18_RS04160	COG0275	rRNA processing
BVV18_RS04165	COG3116	cell division
BVV18_RS04180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BVV18_RS04185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BVV18_RS04200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BVV18_RS04205	COG1181	Belongs to the D-alanine--D-alanine ligase family
BVV18_RS04210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BVV18_RS04225	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BVV18_RS04235	COG0741	lytic transglycosylase activity
BVV18_RS04235	COG1196	nuclear chromosome segregation
BVV18_RS04235	COG0739	heme binding
BVV18_RS04250	COG0494	nUDIX hydrolase
BVV18_RS04265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BVV18_RS04280	COG3321	synthase
BVV18_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS04280	COG0604	alcohol dehydrogenase
BVV18_RS04340	COG2226	methyltransferase
BVV18_RS04345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BVV18_RS04385	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS04410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BVV18_RS04425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BVV18_RS04435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BVV18_RS04440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BVV18_RS04450	COG0667	Aldo Keto reductase
BVV18_RS04480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BVV18_RS04490	COG2175	clavaminate synthase activity
BVV18_RS04500	COG4181	ATPase activity
BVV18_RS04515	COG0642	Histidine kinase
BVV18_RS04530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BVV18_RS04550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BVV18_RS04570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BVV18_RS04575	COG2967	ApaG domain
BVV18_RS04580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BVV18_RS04595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BVV18_RS04610	COG0123	including yeast histone deacetylase and acetoin utilization protein
BVV18_RS04615	COG2096	Adenosyltransferase
BVV18_RS04630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BVV18_RS04635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BVV18_RS04655	COG1802	Transcriptional regulator
BVV18_RS04665	COG3384	dioxygenase
BVV18_RS04670	COG0583	DNA-binding transcription factor activity
BVV18_RS04675	COG0318	PFAM AMP-dependent synthetase and ligase
BVV18_RS04685	COG1024	Enoyl-CoA hydratase
BVV18_RS04705	COG3386	PFAM SMP-30 Gluconolaconase
BVV18_RS04755	COG2197	response regulator
BVV18_RS04765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BVV18_RS04770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BVV18_RS04775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BVV18_RS04785	COG0583	DNA-binding transcription factor activity
BVV18_RS04790	COG3634	alkyl hydroperoxide reductase activity
BVV18_RS04800	COG2890	protein-(glutamine-N5) methyltransferase activity
BVV18_RS04840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BVV18_RS04840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BVV18_RS04910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BVV18_RS04920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BVV18_RS04950	COG1295	ribonuclease BN
BVV18_RS04955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BVV18_RS04960	COG1254	Belongs to the acylphosphatase family
BVV18_RS04975	COG0521	Mo-molybdopterin cofactor biosynthetic process
BVV18_RS04985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BVV18_RS04990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BVV18_RS05000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BVV18_RS05015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BVV18_RS05025	COG0193	aminoacyl-tRNA hydrolase activity
BVV18_RS05030	COG0012	GTP binding
BVV18_RS05065	COG0250	Participates in transcription elongation, termination and antitermination
BVV18_RS05075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BVV18_RS05080	COG0081	regulation of translation
BVV18_RS05085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BVV18_RS05095	COG0085	RNA polymerase activity
BVV18_RS05100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BVV18_RS05105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BVV18_RS05110	COG0049	tRNA binding
BVV18_RS05145	COG0088	Forms part of the polypeptide exit tunnel
BVV18_RS05150	COG0089	rRNA binding
BVV18_RS05155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BVV18_RS05165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BVV18_RS05175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BVV18_RS05180	COG0255	Belongs to the universal ribosomal protein uL29 family
BVV18_RS05185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BVV18_RS05190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BVV18_RS05195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BVV18_RS05230	COG1841	ribosomal large subunit assembly
BVV18_RS05235	COG0200	Binds to the 23S rRNA
BVV18_RS05240	COG0201	protein transport
BVV18_RS05250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BVV18_RS05255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BVV18_RS05265	COG0203	ribosomal protein L17
BVV18_RS05280	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BVV18_RS05300	COG1217	gtp-binding protein TYPA
BVV18_RS05305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BVV18_RS05315	COG0625	glutathione transferase activity
BVV18_RS05350	COG3039	Transposase
BVV18_RS05370	COG0446	pyridine nucleotide-disulphide oxidoreductase
BVV18_RS05370	COG1902	pentaerythritol trinitrate reductase activity
BVV18_RS05375	COG0604	alcohol dehydrogenase
BVV18_RS05405	COG0156	8-amino-7-oxononanoate synthase activity
BVV18_RS05410	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BVV18_RS05415	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BVV18_RS05420	COG4208	sulfate ABC transporter
BVV18_RS05425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BVV18_RS05460	COG0406	alpha-ribazole phosphatase activity
BVV18_RS05475	COG0285	dihydrofolate synthase activity
BVV18_RS05495	COG2833	Protein of unknown function (DUF455)
BVV18_RS05520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BVV18_RS05530	COG0671	phosphoesterase, PA-phosphatase related
BVV18_RS05535	COG0438	transferase activity, transferring glycosyl groups
BVV18_RS05545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BVV18_RS05550	COG5002	protein histidine kinase activity
BVV18_RS05560	COG4783	chaperone-mediated protein folding
BVV18_RS05575	COG0473	3-isopropylmalate dehydrogenase activity
BVV18_RS05620	COG3039	Transposase
BVV18_RS05645	COG0544	peptidyl-prolyl cis-trans isomerase activity
BVV18_RS05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BVV18_RS05710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BVV18_RS05725	COG0631	protein serine/threonine phosphatase activity
BVV18_RS05745	COG3039	Transposase
BVV18_RS05755	COG0859	PFAM glycosyl transferase family 9
BVV18_RS05760	COG3642	lipopolysaccharide core region biosynthetic process
BVV18_RS05765	COG1234	tRNA 3'-trailer cleavage
BVV18_RS05770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BVV18_RS05780	COG0315	cyclic pyranopterin monophosphate synthase activity
BVV18_RS05785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BVV18_RS05790	COG0314	molybdopterin synthase activity
BVV18_RS05825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BVV18_RS05835	COG0537	adenosine 5'-monophosphoramidase activity
BVV18_RS05855	COG0714	Associated with various cellular activities
BVV18_RS05875	COG1399	metal-binding, possibly nucleic acid-binding protein
BVV18_RS05900	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS05905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BVV18_RS05915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BVV18_RS05920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BVV18_RS05950	COG3829	transcription factor binding
BVV18_RS06050	COG0330	HflC and HflK could
BVV18_RS06055	COG0330	HflC and HflK could
BVV18_RS06065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BVV18_RS06070	COG0308	aminopeptidase N
BVV18_RS06105	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BVV18_RS06190	COG0587	DNA-directed DNA polymerase activity
BVV18_RS06210	COG1297	OPT oligopeptide transporter protein
BVV18_RS06225	COG0823	Involved in the tonB-independent uptake of proteins
BVV18_RS06225	COG1506	peptidase
BVV18_RS06235	COG1917	Cupin 2, conserved barrel domain protein
BVV18_RS06235	COG2207	Transcriptional regulator
BVV18_RS06280	COG0753	catalase activity
BVV18_RS06320	COG3551	Protein conserved in bacteria
BVV18_RS06350	COG2194	sulfuric ester hydrolase activity
BVV18_RS06360	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BVV18_RS06365	COG0745	RESPONSE REGULATOR receiver
BVV18_RS06370	COG0642	Histidine kinase
BVV18_RS06380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BVV18_RS06385	COG2894	cell division
BVV18_RS06400	COG4585	Histidine kinase
BVV18_RS06405	COG2197	response regulator
BVV18_RS06420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BVV18_RS06445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BVV18_RS06520	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS06545	COG3039	Transposase
BVV18_RS06680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BVV18_RS06695	COG1842	Phage shock protein A
BVV18_RS06720	COG0754	glutathionylspermidine amidase activity
BVV18_RS06800	COG0531	amino acid
BVV18_RS06805	COG2197	response regulator
BVV18_RS06810	COG2267	carboxylic ester hydrolase activity
BVV18_RS06820	COG1113	amino acid transport
BVV18_RS06850	COG3039	Transposase
BVV18_RS06860	COG1294	oxidase, subunit
BVV18_RS06870	COG2239	Acts as a magnesium transporter
BVV18_RS06880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BVV18_RS06885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BVV18_RS06900	COG3039	Transposase
BVV18_RS06915	COG1660	Displays ATPase and GTPase activities
BVV18_RS06925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BVV18_RS06940	COG1137	ATPase activity
BVV18_RS06945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BVV18_RS06955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BVV18_RS06965	COG0271	Belongs to the BolA IbaG family
BVV18_RS06970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BVV18_RS06995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BVV18_RS07010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BVV18_RS07020	COG0628	permease
BVV18_RS07030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BVV18_RS07035	COG3178	'Phosphotransferase
BVV18_RS07045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BVV18_RS07050	COG1555	photosystem II stabilization
BVV18_RS07075	COG3039	Transposase
BVV18_RS07085	COG2146	nitrite reductase [NAD(P)H] activity
BVV18_RS07095	COG3039	Transposase
BVV18_RS07100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BVV18_RS07105	COG0719	Fe-S assembly protein
BVV18_RS07110	COG0396	ATPase activity
BVV18_RS07115	COG0719	Fe-S assembly protein
BVV18_RS07120	COG1959	2 iron, 2 sulfur cluster binding
BVV18_RS07175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BVV18_RS07210	COG0519	Catalyzes the synthesis of GMP from XMP
BVV18_RS07225	COG1678	Uncharacterized ACR, COG1678
BVV18_RS07230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BVV18_RS07245	COG1764	response to oxidative stress
BVV18_RS07255	COG0384	phenazine biosynthesis protein PhzF
BVV18_RS07265	COG0527	aspartate kinase activity
BVV18_RS07295	COG3039	Transposase
BVV18_RS07305	COG0142	geranyltranstransferase activity
BVV18_RS07310	COG0629	single-stranded DNA binding
BVV18_RS07315	COG2203	Gaf domain
BVV18_RS07315	COG4251	negative regulation of phosphorylation
BVV18_RS07315	COG3706	GGDEF domain
BVV18_RS07315	COG5001	Diguanylate cyclase
BVV18_RS07360	COG2879	small protein
BVV18_RS07365	COG1966	Carbon starvation protein
BVV18_RS07370	COG1741	Belongs to the pirin family
BVV18_RS07475	COG1515	deoxyribonuclease V activity
BVV18_RS07495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BVV18_RS07500	COG2199	diguanylate cyclase activity
BVV18_RS07500	COG2200	EAL domain
BVV18_RS07500	COG2202	Pas domain
BVV18_RS07505	COG0835	chemotaxis
BVV18_RS07510	COG0840	transmembrane signaling receptor activity
BVV18_RS07520	COG0643	Histidine kinase
BVV18_RS07520	COG2198	Histidine kinase
BVV18_RS07530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BVV18_RS07540	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BVV18_RS07575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BVV18_RS07580	COG0735	belongs to the Fur family
BVV18_RS07610	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS07750	COG5001	Diguanylate cyclase
BVV18_RS07750	COG5002	protein histidine kinase activity
BVV18_RS07755	COG1187	pseudouridine synthase activity
BVV18_RS07775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BVV18_RS07785	COG0475	glutathione-regulated potassium exporter activity
BVV18_RS07790	COG5002	protein histidine kinase activity
BVV18_RS07790	COG5000	phosphorelay sensor kinase activity
BVV18_RS07795	COG0745	RESPONSE REGULATOR receiver
BVV18_RS07800	COG1538	Outer membrane efflux protein
BVV18_RS07825	COG1132	(ABC) transporter
BVV18_RS07850	COG3039	Transposase
BVV18_RS07895	COG3118	belongs to the thioredoxin family
BVV18_RS07925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BVV18_RS07945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BVV18_RS07970	COG2968	Membrane
BVV18_RS07985	COG3164	Protein of unknown function
BVV18_RS07995	COG0312	modulator of DNA gyrase
BVV18_RS08000	COG3028	Belongs to the UPF0307 family
BVV18_RS08005	COG0312	modulator of DNA gyrase
BVV18_RS08020	COG4104	PAAR repeat-containing protein
BVV18_RS08030	COG0142	geranyltranstransferase activity
BVV18_RS08035	COG1722	exodeoxyribonuclease VII activity
BVV18_RS08040	COG0037	tRNA processing
BVV18_RS08045	COG1785	Belongs to the alkaline phosphatase family
BVV18_RS08050	COG1301	dicarboxylic acid transport
BVV18_RS08055	COG4106	trans-aconitate 2-methyltransferase activity
BVV18_RS08065	COG0791	NLP P60 protein
BVV18_RS08070	COG0791	NLP P60 protein
BVV18_RS08075	COG1047	Peptidyl-prolyl cis-trans
BVV18_RS08080	COG2311	Membrane
BVV18_RS08085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BVV18_RS08115	COG3039	Transposase
BVV18_RS08125	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS08145	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS08150	COG3039	Transposase
BVV18_RS08165	COG0489	protein tyrosine kinase activity
BVV18_RS08175	COG0717	Belongs to the dCTP deaminase family
BVV18_RS08190	COG3039	Transposase
BVV18_RS08210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BVV18_RS08220	COG3039	Transposase
BVV18_RS08230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BVV18_RS08250	COG0433	COG0433 Predicted ATPase
BVV18_RS08280	COG2890	protein-(glutamine-N5) methyltransferase activity
BVV18_RS08285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BVV18_RS08290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BVV18_RS08295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BVV18_RS08315	COG0101	tRNA pseudouridine synthase activity
BVV18_RS08320	COG0135	phosphoribosylanthranilate isomerase activity
BVV18_RS08330	COG0133	tryptophan synthase activity
BVV18_RS08345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BVV18_RS08350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BVV18_RS08410	COG0149	triose-phosphate isomerase activity
BVV18_RS08425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BVV18_RS08435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BVV18_RS08440	COG0649	NAD binding
BVV18_RS08445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BVV18_RS08450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BVV18_RS08455	COG1034	ATP synthesis coupled electron transport
BVV18_RS08460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BVV18_RS08465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BVV18_RS08490	COG1007	ATP synthesis coupled electron transport
BVV18_RS08500	COG0779	Required for maturation of 30S ribosomal subunits
BVV18_RS08505	COG0195	Participates in both transcription termination and antitermination
BVV18_RS08510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BVV18_RS08525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BVV18_RS08530	COG1185	polyribonucleotide nucleotidyltransferase activity
BVV18_RS08565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BVV18_RS08575	COG2095	MarC family integral membrane protein
BVV18_RS08590	COG1611	Belongs to the LOG family
BVV18_RS08635	COG4969	Belongs to the N-Me-Phe pilin family
BVV18_RS08640	COG0556	nucleotide-excision repair
BVV18_RS08670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BVV18_RS08680	COG2986	histidine ammonia-lyase
BVV18_RS08685	COG1228	amidohydrolase
BVV18_RS08730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BVV18_RS08735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BVV18_RS08740	COG0077	Prephenate dehydratase
BVV18_RS08740	COG1605	Chorismate mutase
BVV18_RS08745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BVV18_RS08770	COG3039	Transposase
BVV18_RS08780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BVV18_RS08795	COG0583	DNA-binding transcription factor activity
BVV18_RS08810	COG2336	PFAM SpoVT AbrB
BVV18_RS08850	COG0840	transmembrane signaling receptor activity
BVV18_RS08875	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BVV18_RS08880	COG0784	Response regulator, receiver
BVV18_RS08880	COG4191	Histidine kinase
BVV18_RS08895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BVV18_RS08915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BVV18_RS08930	COG1595	DNA-templated transcription, initiation
BVV18_RS08980	COG2244	polysaccharide biosynthetic process
BVV18_RS09010	COG2264	protein methyltransferase activity
BVV18_RS09020	COG0438	transferase activity, transferring glycosyl groups
BVV18_RS09035	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BVV18_RS09040	COG1132	(ABC) transporter
BVV18_RS09050	COG2271	Major facilitator Superfamily
BVV18_RS09070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BVV18_RS09085	COG1253	flavin adenine dinucleotide binding
BVV18_RS09100	COG0306	phosphate transporter
BVV18_RS09130	COG0504	CTP synthase activity
BVV18_RS09135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BVV18_RS09140	COG0148	phosphopyruvate hydratase activity
BVV18_RS09145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BVV18_RS09160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BVV18_RS09170	COG2840	Smr protein MutS2
BVV18_RS09175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BVV18_RS09180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BVV18_RS09185	COG1238	metal cluster binding
BVV18_RS09200	COG1534	Rna-binding protein
BVV18_RS09205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BVV18_RS09215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BVV18_RS09230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BVV18_RS09235	COG1546	Belongs to the CinA family
BVV18_RS09250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BVV18_RS09260	COG2137	regulation of response to DNA damage stimulus
BVV18_RS09265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BVV18_RS09270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BVV18_RS09325	COG1741	Belongs to the pirin family
BVV18_RS09330	COG0583	DNA-binding transcription factor activity
BVV18_RS09355	COG0351	phosphomethylpyrimidine kinase
BVV18_RS09355	COG0352	thiamine-phosphate diphosphorylase activity
BVV18_RS09365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BVV18_RS09370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BVV18_RS09385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BVV18_RS09395	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BVV18_RS09400	COG3734	2-keto-3-deoxy-galactonokinase
BVV18_RS09410	COG4948	Mandelate Racemase Muconate Lactonizing
BVV18_RS09415	COG0800	Aldolase
BVV18_RS09440	COG1070	Carbohydrate kinase
BVV18_RS09450	COG0477	Major facilitator Superfamily
BVV18_RS09470	COG0860	N-Acetylmuramoyl-L-alanine amidase
BVV18_RS09475	COG1469	GTP cyclohydrolase I activity
BVV18_RS09485	COG0617	tRNA 3'-terminal CCA addition
BVV18_RS09505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BVV18_RS09535	COG1472	Belongs to the glycosyl hydrolase 3 family
BVV18_RS09555	COG3706	GGDEF domain
BVV18_RS09555	COG5001	Diguanylate cyclase
BVV18_RS09555	COG4251	negative regulation of phosphorylation
BVV18_RS09555	COG2203	Gaf domain
BVV18_RS09565	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BVV18_RS09575	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BVV18_RS09590	COG0671	phosphoesterase, PA-phosphatase related
BVV18_RS09610	COG1794	racemase activity, acting on amino acids and derivatives
BVV18_RS09620	COG0697	spore germination
BVV18_RS09625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BVV18_RS09650	COG1012	belongs to the aldehyde dehydrogenase family
BVV18_RS09710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BVV18_RS09725	COG0124	histidyl-tRNA synthetase
BVV18_RS09745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BVV18_RS09760	COG0131	Imidazoleglycerol-phosphate dehydratase
BVV18_RS09760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BVV18_RS09770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BVV18_RS09780	COG0140	phosphoribosyl-ATP diphosphatase activity
BVV18_RS09780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BVV18_RS09805	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BVV18_RS09810	COG0235	Class ii aldolase
BVV18_RS09815	COG0531	amino acid
BVV18_RS09820	COG0531	amino acid
BVV18_RS09830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BVV18_RS09835	COG0277	FAD linked oxidase domain protein
BVV18_RS09860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BVV18_RS09910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BVV18_RS09915	COG2258	MOSC domain
BVV18_RS09920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BVV18_RS09925	COG0505	Belongs to the CarA family
BVV18_RS09935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BVV18_RS09940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BVV18_RS09950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BVV18_RS09965	COG3279	Response regulator of the LytR AlgR family
BVV18_RS09990	COG2205	protein histidine kinase activity
BVV18_RS09990	COG0784	Response regulator, receiver
BVV18_RS09990	COG2198	Histidine kinase
BVV18_RS09995	COG1024	Enoyl-CoA hydratase
BVV18_RS10000	COG0318	PFAM AMP-dependent synthetase and ligase
BVV18_RS10030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BVV18_RS10060	COG0840	transmembrane signaling receptor activity
BVV18_RS10070	COG0835	chemotaxis
BVV18_RS10085	COG0840	transmembrane signaling receptor activity
BVV18_RS10090	COG0840	transmembrane signaling receptor activity
BVV18_RS10095	COG0840	transmembrane signaling receptor activity
BVV18_RS10110	COG0840	transmembrane signaling receptor activity
BVV18_RS10120	COG0840	transmembrane signaling receptor activity
BVV18_RS10125	COG0840	transmembrane signaling receptor activity
BVV18_RS10155	COG0840	transmembrane signaling receptor activity
BVV18_RS10165	COG0745	RESPONSE REGULATOR receiver
BVV18_RS10175	COG0835	chemotaxis
BVV18_RS10180	COG1192	Involved in chromosome partitioning
BVV18_RS10185	COG1360	Flagellar Motor Protein
BVV18_RS10190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BVV18_RS10210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BVV18_RS10250	COG3039	Transposase
BVV18_RS10315	COG0643	Histidine kinase
BVV18_RS10315	COG0784	Response regulator, receiver
BVV18_RS10315	COG2198	Histidine kinase
BVV18_RS10370	COG1684	flagellar biosynthetic protein fliR
BVV18_RS10385	COG3190	flagellar
BVV18_RS10435	COG1677	Flagellar hook-basal body complex protein FliE
BVV18_RS10470	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS10480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BVV18_RS10500	COG2201	protein-glutamate methylesterase activity
BVV18_RS10530	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BVV18_RS10535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BVV18_RS10550	COG3951	Flagellar rod assembly protein muramidase FlgJ
BVV18_RS10550	COG1705	Flagellar rod assembly protein muramidase FlgJ
BVV18_RS10555	COG1706	bacterial-type flagellum-dependent cell motility
BVV18_RS10560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BVV18_RS10575	COG4787	bacterial-type flagellum-dependent cell motility
BVV18_RS10585	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BVV18_RS10590	COG1558	bacterial-type flagellum-dependent cell motility
BVV18_RS10600	COG0784	Response regulator, receiver
BVV18_RS10600	COG0835	chemotaxis
BVV18_RS10620	COG5002	protein histidine kinase activity
BVV18_RS10630	COG4585	Histidine kinase
BVV18_RS10665	COG0482	sulfurtransferase activity
BVV18_RS10680	COG0542	response to heat
BVV18_RS10705	COG0492	ferredoxin-NADP+ reductase activity
BVV18_RS10710	COG1674	ftsk spoiiie
BVV18_RS10735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BVV18_RS10755	COG0038	chloride channel
BVV18_RS10760	COG0183	Belongs to the thiolase family
BVV18_RS10765	COG1250	3-hydroxyacyl-CoA dehydrogenase
BVV18_RS10765	COG1024	Enoyl-CoA hydratase
BVV18_RS10780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BVV18_RS10800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BVV18_RS10805	COG1160	GTP binding
BVV18_RS10810	COG0303	'Molybdopterin
BVV18_RS10820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BVV18_RS10830	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS10840	COG3039	Transposase
BVV18_RS10865	COG0746	molybdenum cofactor guanylyltransferase activity
BVV18_RS10890	COG1648	precorrin-2 dehydrogenase activity
BVV18_RS10890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BVV18_RS10930	COG3039	Transposase
BVV18_RS10955	COG5001	Diguanylate cyclase
BVV18_RS10965	COG3039	Transposase
BVV18_RS10975	COG4566	intracellular signal transduction
BVV18_RS11110	COG1024	Enoyl-CoA hydratase
BVV18_RS11115	COG1024	Enoyl-CoA hydratase
BVV18_RS11125	COG1024	Enoyl-CoA hydratase
BVV18_RS11140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BVV18_RS11165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BVV18_RS11170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BVV18_RS11225	COG1858	cytochrome C peroxidase
BVV18_RS11255	COG0515	serine threonine protein kinase
BVV18_RS11260	COG0631	protein serine/threonine phosphatase activity
BVV18_RS11325	COG3039	Transposase
BVV18_RS11410	COG3039	Transposase
BVV18_RS11425	COG2154	pterin-4-alpha-carbinolamine dehydratase
BVV18_RS11440	COG3064	Membrane
BVV18_RS11450	COG1530	ribonuclease E activity
BVV18_RS11465	COG1054	Belongs to the UPF0176 family
BVV18_RS11485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BVV18_RS11525	COG0322	excinuclease ABC activity
BVV18_RS11535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BVV18_RS11545	COG1663	tetraacyldisaccharide 4'-kinase activity
BVV18_RS11560	COG0811	peptide transport
BVV18_RS11585	COG4591	ABC-type transport system involved in lipoprotein release permease component
BVV18_RS11600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BVV18_RS11615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BVV18_RS11630	COG0354	folic acid binding
BVV18_RS11645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BVV18_RS11655	COG0363	glucosamine-6-phosphate deaminase activity
BVV18_RS11660	COG0129	dihydroxy-acid dehydratase activity
BVV18_RS11665	COG0800	Aldolase
BVV18_RS11745	COG0784	Response regulator, receiver
BVV18_RS11745	COG2205	protein histidine kinase activity
BVV18_RS11760	COG2183	response to ionizing radiation
BVV18_RS11770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BVV18_RS11770	COG0723	plastoquinol--plastocyanin reductase activity
BVV18_RS11785	COG3243	poly(R)-hydroxyalkanoic acid synthase
BVV18_RS11795	COG1183	phosphatidylcholine synthase activity
BVV18_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS11815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BVV18_RS11825	COG0668	transmembrane transport
BVV18_RS11845	COG1914	H( )-stimulated, divalent metal cation uptake system
BVV18_RS11875	COG0583	DNA-binding transcription factor activity
BVV18_RS11900	COG0583	DNA-binding transcription factor activity
BVV18_RS11905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BVV18_RS11910	COG3002	Belongs to the UPF0753 family
BVV18_RS11915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BVV18_RS11915	COG0519	Catalyzes the synthesis of GMP from XMP
BVV18_RS11925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BVV18_RS11940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BVV18_RS11950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BVV18_RS11955	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BVV18_RS11965	COG0776	regulation of translation
BVV18_RS11970	COG0539	negative regulation of cytoplasmic translation
BVV18_RS11975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BVV18_RS11990	COG2957	Belongs to the agmatine deiminase family
BVV18_RS12000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BVV18_RS12025	COG0395	ABC-type sugar transport system, permease component
BVV18_RS12030	COG1175	transmembrane transport
BVV18_RS12060	COG2350	Protein conserved in bacteria
BVV18_RS12065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BVV18_RS12070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BVV18_RS12075	COG1187	pseudouridine synthase activity
BVV18_RS12095	COG0436	Aminotransferase
BVV18_RS12100	COG4133	protoheme IX ABC transporter activity
BVV18_RS12150	COG1278	Cold shock
BVV18_RS12160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BVV18_RS12165	COG4988	ABC transporter
BVV18_RS12175	COG1271	oxidase subunit
BVV18_RS12230	COG0165	Argininosuccinate lyase
BVV18_RS12245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BVV18_RS12250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BVV18_RS12255	COG0137	argininosuccinate synthase activity
BVV18_RS12260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BVV18_RS12275	COG2166	iron-sulfur cluster assembly
BVV18_RS12300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BVV18_RS12315	COG4302	ethanolamine ammonia-lyase activity
BVV18_RS12330	COG4677	pectinesterase activity
BVV18_RS12335	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS12360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BVV18_RS12365	COG0402	S-adenosylhomocysteine deaminase activity
BVV18_RS12385	COG1509	lysine 2,3-aminomutase activity
BVV18_RS12390	COG5001	Diguanylate cyclase
BVV18_RS12390	COG3300	MHYT domain
BVV18_RS12405	COG0483	inositol monophosphate 1-phosphatase activity
BVV18_RS12410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BVV18_RS12435	COG0488	(ABC) transporter
BVV18_RS12440	COG0513	Belongs to the DEAD box helicase family
BVV18_RS12450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BVV18_RS12460	COG0625	glutathione transferase activity
BVV18_RS12470	COG1671	Belongs to the UPF0178 family
BVV18_RS12475	COG4681	YaeQ
BVV18_RS12480	COG2081	HI0933 family
BVV18_RS12485	COG1716	ATPase activity
BVV18_RS12485	COG5001	Diguanylate cyclase
BVV18_RS12490	COG0501	Belongs to the peptidase M48B family
BVV18_RS12500	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS12520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BVV18_RS12525	COG0860	N-Acetylmuramoyl-L-alanine amidase
BVV18_RS12530	COG0802	atpase or kinase
BVV18_RS12535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BVV18_RS12535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BVV18_RS12540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BVV18_RS12560	COG3039	Transposase
BVV18_RS12570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BVV18_RS12620	COG0835	chemotaxis
BVV18_RS12625	COG0840	transmembrane signaling receptor activity
BVV18_RS12655	COG2969	positive regulation of protein catabolic process
BVV18_RS12660	COG0625	glutathione transferase activity
BVV18_RS12665	COG2857	Cytochrome c1
BVV18_RS12670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BVV18_RS12675	COG0723	plastoquinol--plastocyanin reductase activity
BVV18_RS12685	COG0741	lytic transglycosylase activity
BVV18_RS12710	COG1702	phosphate starvation-inducible protein PhoH
BVV18_RS12730	COG4535	Mg2 and Co2 transporter CorC
BVV18_RS12745	COG1012	belongs to the aldehyde dehydrogenase family
BVV18_RS12750	COG1177	transmembrane transport
BVV18_RS12755	COG1176	ABC-type spermidine putrescine transport system, permease component I
BVV18_RS12765	COG3842	ATPase activity
BVV18_RS12795	COG3039	Transposase
BVV18_RS12820	COG0174	glutamine synthetase
BVV18_RS12825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BVV18_RS12835	COG0477	Major facilitator Superfamily
BVV18_RS12845	COG0243	molybdopterin cofactor binding
BVV18_RS12855	COG2223	nitrite transmembrane transporter activity
BVV18_RS12865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BVV18_RS12870	COG1121	(ABC) transporter
BVV18_RS12880	COG2733	membrane
BVV18_RS12885	COG2205	protein histidine kinase activity
BVV18_RS12885	COG5002	protein histidine kinase activity
BVV18_RS12885	COG0784	Response regulator, receiver
BVV18_RS12895	COG3039	Transposase
BVV18_RS12900	COG2902	Dehydrogenase
BVV18_RS12910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BVV18_RS12915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BVV18_RS12930	COG1609	Transcriptional regulator
BVV18_RS12935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BVV18_RS12935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BVV18_RS12940	COG1105	Belongs to the carbohydrate kinase PfkB family
BVV18_RS12945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BVV18_RS12945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BVV18_RS12970	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS13005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BVV18_RS13015	COG1862	Preprotein translocase
BVV18_RS13020	COG0343	queuine tRNA-ribosyltransferase activity
BVV18_RS13085	COG0405	Gamma-glutamyltransferase
BVV18_RS13090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BVV18_RS13105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BVV18_RS13110	COG0742	ribosomal rna small subunit methyltransferase
BVV18_RS13115	COG0326	Molecular chaperone. Has ATPase activity
BVV18_RS13160	COG4206	TonB-dependent receptor
BVV18_RS13215	COG0531	amino acid
BVV18_RS13230	COG0006	proline dipeptidase activity
BVV18_RS13240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BVV18_RS13255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BVV18_RS13260	COG3938	Belongs to the proline racemase family
BVV18_RS13270	COG0552	protein localization to endoplasmic reticulum
BVV18_RS13285	COG1194	a g-specific adenine glycosylase
BVV18_RS13295	COG0784	Response regulator, receiver
BVV18_RS13295	COG4191	Histidine kinase
BVV18_RS13300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BVV18_RS13325	COG3040	lipid binding
BVV18_RS13335	COG1960	acyl-CoA dehydrogenase activity
BVV18_RS13345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BVV18_RS13375	COG0438	transferase activity, transferring glycosyl groups
BVV18_RS13385	COG0438	transferase activity, transferring glycosyl groups
BVV18_RS13390	COG0438	transferase activity, transferring glycosyl groups
BVV18_RS13445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BVV18_RS13460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BVV18_RS13485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BVV18_RS13500	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BVV18_RS13505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BVV18_RS13510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BVV18_RS13515	COG3115	cell septum assembly
BVV18_RS13535	COG0360	Binds together with S18 to 16S ribosomal RNA
BVV18_RS13540	COG0316	Belongs to the HesB IscA family
BVV18_RS13575	COG0288	reversible hydration of carbon dioxide
BVV18_RS13600	COG3844	kynureninase activity
BVV18_RS13610	COG2925	Exonuclease
BVV18_RS13620	COG0667	Aldo Keto reductase
BVV18_RS13650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BVV18_RS13650	COG0116	Belongs to the methyltransferase superfamily
BVV18_RS13695	COG0494	nUDIX hydrolase
BVV18_RS13705	COG1024	Enoyl-CoA hydratase
BVV18_RS13715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BVV18_RS13720	COG0659	secondary active sulfate transmembrane transporter activity
BVV18_RS13730	COG3039	Transposase
BVV18_RS13750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BVV18_RS13755	COG0573	inorganic phosphate transmembrane transporter activity
BVV18_RS13770	COG0704	Plays a role in the regulation of phosphate uptake
BVV18_RS13780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BVV18_RS13790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BVV18_RS13805	COG0557	exoribonuclease II activity
BVV18_RS13835	COG1960	acyl-CoA dehydrogenase activity
BVV18_RS13840	COG2226	methyltransferase
BVV18_RS13845	COG1410	methionine synthase
BVV18_RS13845	COG0646	methionine synthase
BVV18_RS13850	COG1410	methionine synthase
BVV18_RS13850	COG0646	methionine synthase
BVV18_RS13860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BVV18_RS13870	COG1609	Transcriptional regulator
BVV18_RS13885	COG2900	Belongs to the SlyX family
BVV18_RS13900	COG0386	Belongs to the glutathione peroxidase family
BVV18_RS13910	COG1725	Transcriptional regulator
BVV18_RS13915	COG1131	(ABC) transporter
BVV18_RS13955	COG3039	Transposase
BVV18_RS13965	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS13990	COG2850	peptidyl-arginine hydroxylation
BVV18_RS14025	COG1132	(ABC) transporter
BVV18_RS14055	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BVV18_RS14065	COG0484	heat shock protein binding
BVV18_RS14070	COG0443	Heat shock 70 kDa protein
BVV18_RS14075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BVV18_RS14085	COG0497	DNA recombination
BVV18_RS14095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BVV18_RS14105	COG2914	Belongs to the UPF0125 (RnfH) family
BVV18_RS14115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BVV18_RS14140	COG3039	Transposase
BVV18_RS14175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BVV18_RS14190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BVV18_RS14200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BVV18_RS14205	COG0174	glutamine synthetase
BVV18_RS14285	COG0415	Belongs to the DNA photolyase family
BVV18_RS14290	COG0305	Participates in initiation and elongation during chromosome replication
BVV18_RS14300	COG0367	asparagine synthase
BVV18_RS14330	COG0084	hydrolase, TatD family'
BVV18_RS14335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BVV18_RS14375	COG0840	transmembrane signaling receptor activity
BVV18_RS14390	COG3039	Transposase
BVV18_RS14400	COG3039	Transposase
BVV18_RS14435	COG0386	Belongs to the glutathione peroxidase family
BVV18_RS14535	COG2814	Major facilitator Superfamily
BVV18_RS14540	COG1566	PFAM secretion protein HlyD family protein
BVV18_RS14555	COG2207	Transcriptional regulator
BVV18_RS14585	COG4774	siderophore transport
BVV18_RS14595	COG0367	asparagine synthase
BVV18_RS14600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BVV18_RS14610	COG1393	Belongs to the ArsC family
BVV18_RS14670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BVV18_RS14685	COG0233	cytoplasmic translational termination
BVV18_RS14695	COG0575	Belongs to the CDS family
BVV18_RS14700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BVV18_RS14705	COG0750	zinc metalloprotease
BVV18_RS14725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BVV18_RS14730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BVV18_RS14750	COG0825	malonyl-CoA metabolic process
BVV18_RS14775	COG1981	membrane
BVV18_RS14825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BVV18_RS14840	COG2040	homocysteine
BVV18_RS14845	COG0833	amino acid
BVV18_RS14850	COG0346	lactoylglutathione lyase activity
BVV18_RS14860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BVV18_RS14860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BVV18_RS14870	COG2878	Part of a membrane complex involved in electron transport
BVV18_RS14890	COG1595	DNA-templated transcription, initiation
BVV18_RS14915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BVV18_RS14930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BVV18_RS14935	COG0251	oxidation-reduction process
BVV18_RS14945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BVV18_RS14945	COG0392	lysyltransferase activity
BVV18_RS14985	COG2814	Major facilitator Superfamily
BVV18_RS14990	COG1902	pentaerythritol trinitrate reductase activity
BVV18_RS15005	COG2824	Alkylphosphonate utilization operon protein PhnA
BVV18_RS15015	COG1047	Peptidyl-prolyl cis-trans
BVV18_RS15060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BVV18_RS15075	COG1451	nucleotide metabolic process
BVV18_RS15095	COG0183	Belongs to the thiolase family
BVV18_RS15125	COG1793	dna ligase
BVV18_RS15125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BVV18_RS15135	COG1793	dna ligase
BVV18_RS15140	COG1201	RNA secondary structure unwinding
BVV18_RS15160	COG1278	Cold shock
BVV18_RS15165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BVV18_RS15170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BVV18_RS15180	COG3046	protein related to deoxyribodipyrimidine photolyase
BVV18_RS15185	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BVV18_RS15190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BVV18_RS15195	COG2954	triphosphatase activity
BVV18_RS15210	COG1381	Involved in DNA repair and RecF pathway recombination
BVV18_RS15240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BVV18_RS15255	COG1250	3-hydroxyacyl-CoA dehydrogenase
BVV18_RS15255	COG1024	Enoyl-CoA hydratase
BVV18_RS15275	COG1024	Enoyl-CoA hydratase
BVV18_RS15280	COG1960	acyl-CoA dehydrogenase activity
BVV18_RS15355	COG2353	YceI-like domain
BVV18_RS15380	COG1760	l-serine dehydratase
BVV18_RS15390	COG0626	cystathionine gamma-synthase activity
BVV18_RS15395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BVV18_RS15400	COG0739	heme binding
BVV18_RS15410	COG1272	protein, Hemolysin III
BVV18_RS15440	COG0517	IMP dehydrogenase activity
BVV18_RS15440	COG0516	GMP reductase activity
BVV18_RS15445	COG0463	Glycosyl transferase, family 2
BVV18_RS15455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BVV18_RS15465	COG4771	TonB-dependent receptor
BVV18_RS15470	COG1309	transcriptional regulator
BVV18_RS15480	COG1960	acyl-CoA dehydrogenase activity
BVV18_RS15510	COG0509	glycine decarboxylation via glycine cleavage system
BVV18_RS15525	COG0330	HflC and HflK could
BVV18_RS15535	COG1742	UPF0060 membrane protein
BVV18_RS15540	COG3956	TIGRFAM MazG family protein
BVV18_RS15550	COG0494	nUDIX hydrolase
BVV18_RS15560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BVV18_RS15565	COG0837	glucose binding
BVV18_RS15580	COG3858	chitin binding
BVV18_RS15580	COG1388	LysM domain
BVV18_RS15600	COG1472	Belongs to the glycosyl hydrolase 3 family
BVV18_RS15645	COG3537	Alpha-1,2-mannosidase
BVV18_RS15690	COG3142	Participates in the control of copper homeostasis
BVV18_RS15695	COG1446	asparaginase
BVV18_RS15705	COG2304	oxidoreductase activity
BVV18_RS15730	COG0643	Histidine kinase
BVV18_RS15730	COG2198	Histidine kinase
BVV18_RS15730	COG0784	Response regulator, receiver
BVV18_RS15735	COG0840	transmembrane signaling receptor activity
BVV18_RS15740	COG0835	chemotaxis
BVV18_RS15755	COG0189	ligase activity
BVV18_RS15765	COG1397	ADP-ribosylglycohydrolase
BVV18_RS15775	COG1199	ATP-dependent helicase activity
BVV18_RS15785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BVV18_RS15790	COG1215	transferase activity, transferring glycosyl groups
BVV18_RS15800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BVV18_RS15850	COG1643	Atp-dependent helicase
BVV18_RS15855	COG0783	Belongs to the Dps family
BVV18_RS15870	COG0514	ATP-dependent DNA helicase (RecQ)
BVV18_RS15885	COG3039	Transposase
BVV18_RS15900	COG1187	pseudouridine synthase activity
BVV18_RS15940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BVV18_RS15950	COG0602	queuosine metabolic process
BVV18_RS15960	COG2885	chlorophyll binding
BVV18_RS15965	COG0823	Involved in the tonB-independent uptake of proteins
BVV18_RS15975	COG0848	biopolymer transport protein
BVV18_RS15985	COG0824	Thioesterase
BVV18_RS15990	COG2255	four-way junction helicase activity
BVV18_RS16005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BVV18_RS16025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BVV18_RS16040	COG0477	Major facilitator Superfamily
BVV18_RS16075	COG0488	(ABC) transporter
BVV18_RS16105	COG4651	solute:proton antiporter activity
BVV18_RS16105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BVV18_RS16150	COG4772	TonB-dependent receptor
BVV18_RS16160	COG4264	IucA IucC family
BVV18_RS16165	COG2814	Major facilitator Superfamily
BVV18_RS16175	COG0019	diaminopimelate decarboxylase activity
BVV18_RS16230	COG4206	TonB-dependent receptor
BVV18_RS16260	COG0542	response to heat
BVV18_RS16285	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BVV18_RS16295	COG0534	Mate efflux family protein
BVV18_RS16310	COG0336	Belongs to the RNA methyltransferase TrmD family
BVV18_RS16315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BVV18_RS16320	COG0228	four-way junction DNA binding
BVV18_RS16345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BVV18_RS16350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BVV18_RS16390	COG2172	sigma factor antagonist activity
BVV18_RS16395	COG1366	Belongs to the anti-sigma-factor antagonist family
BVV18_RS16400	COG1366	Belongs to the anti-sigma-factor antagonist family
BVV18_RS16410	COG0326	Molecular chaperone. Has ATPase activity
BVV18_RS16415	COG2207	Transcriptional regulator
BVV18_RS16475	COG3039	Transposase
BVV18_RS16500	COG3209	COG3209 Rhs family protein
BVV18_RS16520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BVV18_RS16525	COG1845	cytochrome c oxidase, subunit III
BVV18_RS16530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BVV18_RS16545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BVV18_RS16550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BVV18_RS16565	COG0728	peptidoglycan biosynthetic process
BVV18_RS16570	COG0268	Binds directly to 16S ribosomal RNA
BVV18_RS16575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BVV18_RS16580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BVV18_RS16590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BVV18_RS16595	COG0824	Thioesterase
BVV18_RS16610	COG1946	Acyl-CoA thioesterase
BVV18_RS16620	COG1595	DNA-templated transcription, initiation
BVV18_RS16635	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BVV18_RS16675	COG1877	trehalose-phosphatase activity
BVV18_RS16680	COG3387	PFAM Glycoside hydrolase 15-related
BVV18_RS16720	COG0564	pseudouridine synthase activity
BVV18_RS16725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BVV18_RS16730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BVV18_RS16730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BVV18_RS16745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BVV18_RS16750	COG0045	succinate-CoA ligase (ADP-forming) activity
BVV18_RS16790	COG2194	sulfuric ester hydrolase activity
BVV18_RS16795	COG4969	Belongs to the N-Me-Phe pilin family
BVV18_RS16805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BVV18_RS16810	COG0237	dephospho-CoA kinase activity
BVV18_RS16815	COG2205	protein histidine kinase activity
BVV18_RS16820	COG0745	RESPONSE REGULATOR receiver
BVV18_RS16840	COG3039	Transposase
BVV18_RS16855	COG3039	Transposase
BVV18_RS16885	COG3039	Transposase
BVV18_RS16910	COG2022	thiamine diphosphate biosynthetic process
BVV18_RS16925	COG3273	potassium ion transport
BVV18_RS16925	COG0471	metal ion transport
BVV18_RS16955	COG1970	mechanosensitive ion channel activity
BVV18_RS16990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BVV18_RS17000	COG0308	aminopeptidase N
BVV18_RS17005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BVV18_RS17015	COG0529	Catalyzes the synthesis of activated sulfate
BVV18_RS17015	COG2895	sulfate adenylyltransferase (ATP) activity
BVV18_RS17020	COG0175	sulfate reduction
BVV18_RS17025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BVV18_RS17030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BVV18_RS17035	COG0175	sulfate reduction
BVV18_RS17055	COG0784	Response regulator, receiver
BVV18_RS17055	COG2205	protein histidine kinase activity
BVV18_RS17055	COG2198	Histidine kinase
BVV18_RS17100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BVV18_RS17105	COG3588	fructose-bisphosphate aldolase
BVV18_RS17110	COG0469	pyruvate kinase activity
BVV18_RS17140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BVV18_RS17155	COG3453	Protein conserved in bacteria
BVV18_RS17155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BVV18_RS17160	COG0725	ABC transporter, periplasmic molybdate-binding protein
BVV18_RS17165	COG4149	molybdate abc transporter
BVV18_RS17170	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BVV18_RS17190	COG0642	Histidine kinase
BVV18_RS17205	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS17215	COG1022	Amp-dependent synthetase and ligase
BVV18_RS17245	COG1376	ErfK ybiS ycfS ynhG family protein
BVV18_RS17250	COG0739	heme binding
BVV18_RS17265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BVV18_RS17270	COG1301	dicarboxylic acid transport
BVV18_RS17290	COG2304	oxidoreductase activity
BVV18_RS17310	COG0714	Associated with various cellular activities
BVV18_RS17345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BVV18_RS17380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BVV18_RS17390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BVV18_RS17410	COG1561	YicC-like family, N-terminal region
BVV18_RS17415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BVV18_RS17430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BVV18_RS17460	COG0006	proline dipeptidase activity
BVV18_RS17485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BVV18_RS17505	COG2912	Transglutaminase-like superfamily
BVV18_RS17510	COG1773	rubredoxin
BVV18_RS17515	COG0352	thiamine-phosphate diphosphorylase activity
BVV18_RS17530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BVV18_RS17545	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BVV18_RS17585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BVV18_RS17610	COG0671	phosphoesterase, PA-phosphatase related
BVV18_RS17625	COG3781	membrane
BVV18_RS17635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BVV18_RS17650	COG3039	Transposase
BVV18_RS17665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BVV18_RS17675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BVV18_RS17700	COG3710	Transcriptional regulator
BVV18_RS17705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BVV18_RS17715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BVV18_RS17745	COG2226	methyltransferase
BVV18_RS17750	COG0066	3-isopropylmalate dehydratase activity
BVV18_RS17755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BVV18_RS17775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BVV18_RS17780	COG1538	Outer membrane efflux protein
BVV18_RS17785	COG1519	Transferase
BVV18_RS17790	COG1560	Kdo2-lipid A biosynthetic process
BVV18_RS17820	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS17855	COG0280	phosphate acetyltransferase
BVV18_RS17855	COG0281	malic enzyme
BVV18_RS17875	COG4191	Histidine kinase
BVV18_RS17890	COG0583	DNA-binding transcription factor activity
BVV18_RS17910	COG2197	response regulator
BVV18_RS17920	COG0642	Histidine kinase
BVV18_RS17940	COG2851	Citrate transporter
BVV18_RS17945	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS17955	COG1609	Transcriptional regulator
BVV18_RS17960	COG2211	Major facilitator Superfamily
BVV18_RS17990	COG0436	Aminotransferase
BVV18_RS18010	COG0726	polysaccharide deacetylase
BVV18_RS18015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BVV18_RS18035	COG0402	S-adenosylhomocysteine deaminase activity
BVV18_RS18085	COG0242	peptide deformylase activity
BVV18_RS18090	COG3039	Transposase
BVV18_RS18125	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BVV18_RS18185	COG2188	Transcriptional regulator
BVV18_RS18200	COG1450	Type ii and iii secretion system protein
BVV18_RS18215	COG3166	PFAM Fimbrial assembly family protein
BVV18_RS18220	COG3156	type II secretion system protein K
BVV18_RS18225	COG4795	General secretion pathway protein
BVV18_RS18230	COG2165	general secretion pathway protein
BVV18_RS18235	COG4970	Tfp pilus assembly protein FimT
BVV18_RS18240	COG2165	general secretion pathway protein
BVV18_RS18245	COG1459	type II secretion system
BVV18_RS18255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BVV18_RS18260	COG1404	Belongs to the peptidase S8 family
BVV18_RS18265	COG5295	Hep Hag repeat protein
BVV18_RS18275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BVV18_RS18275	COG0047	phosphoribosylformylglycinamidine synthase activity
BVV18_RS18285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BVV18_RS18290	COG4974	Belongs to the 'phage' integrase family
BVV18_RS18305	COG0795	lipopolysaccharide-transporting ATPase activity
BVV18_RS18315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BVV18_RS18340	COG0525	valine-tRNA ligase activity
BVV18_RS18370	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS18380	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS18405	COG1183	phosphatidylcholine synthase activity
BVV18_RS18415	COG0442	prolyl-tRNA aminoacylation
BVV18_RS18430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BVV18_RS18435	COG1127	ABC transporter
BVV18_RS18440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BVV18_RS18440	COG3218	ABC-type transport auxiliary lipoprotein component
BVV18_RS18490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BVV18_RS18495	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BVV18_RS18495	COG0662	Cupin 2, conserved barrel domain protein
BVV18_RS18520	COG2086	electron transfer activity
BVV18_RS18605	COG0626	cystathionine gamma-synthase activity
BVV18_RS18635	COG0625	glutathione transferase activity
BVV18_RS18650	COG0513	Belongs to the DEAD box helicase family
BVV18_RS18660	COG0720	synthase
BVV18_RS18670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BVV18_RS18675	COG1956	GAF domain-containing protein
BVV18_RS18685	COG3039	Transposase
BVV18_RS18690	COG0546	phosphoglycolate phosphatase activity
BVV18_RS18720	COG0339	signal peptide processing
BVV18_RS18770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BVV18_RS18835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BVV18_RS18840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BVV18_RS18845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BVV18_RS18855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BVV18_RS18865	COG0356	it plays a direct role in the translocation of protons across the membrane
BVV18_RS18885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BVV18_RS18895	COG0508	dehydrogenase complex catalyzes the overall conversion of
BVV18_RS18930	COG2011	ABC-type metal ion transport system permease component
BVV18_RS18940	COG0697	spore germination
BVV18_RS18980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BVV18_RS18990	COG2813	Specifically methylates the guanine in position
BVV18_RS19020	COG2202	Pas domain
BVV18_RS19020	COG2205	protein histidine kinase activity
BVV18_RS19045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BVV18_RS19105	COG0745	RESPONSE REGULATOR receiver
BVV18_RS19120	COG1404	Belongs to the peptidase S8 family
BVV18_RS19135	COG0842	Transport permease protein
BVV18_RS19140	COG1131	(ABC) transporter
BVV18_RS19145	COG0025	NhaP-type Na H and K H
BVV18_RS19155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BVV18_RS19165	COG1573	uracil-dna glycosylase
BVV18_RS19175	COG3384	dioxygenase
BVV18_RS19190	COG0667	Aldo Keto reductase
BVV18_RS19205	COG3590	peptidase
BVV18_RS19225	COG0531	amino acid
BVV18_RS19250	COG3685	Protein conserved in bacteria
BVV18_RS19255	COG3546	catalase activity
BVV18_RS19280	COG3039	Transposase
BVV18_RS19310	COG1271	oxidase subunit
BVV18_RS19315	COG1294	oxidase, subunit
BVV18_RS19350	COG1063	alcohol dehydrogenase
BVV18_RS19445	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BVV18_RS19445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BVV18_RS19455	COG1473	amidohydrolase
BVV18_RS19460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BVV18_RS19465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BVV18_RS19490	COG5383	Protein conserved in bacteria
BVV18_RS19540	COG3023	N-Acetylmuramoyl-L-alanine amidase
BVV18_RS19550	COG4948	Mandelate Racemase Muconate Lactonizing
BVV18_RS19575	COG0531	amino acid
BVV18_RS19595	COG4682	membrane
BVV18_RS19600	COG2133	pyrroloquinoline quinone binding
BVV18_RS19620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BVV18_RS19625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BVV18_RS19635	COG1610	YqeY-like protein
BVV18_RS19655	COG1295	ribonuclease BN
BVV18_RS19660	COG0358	DNA primase activity
BVV18_RS19730	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BVV18_RS19745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BVV18_RS19805	COG0739	heme binding
BVV18_RS19820	COG2211	Major facilitator Superfamily
BVV18_RS19825	COG0708	Exodeoxyribonuclease III
BVV18_RS19840	COG1192	Involved in chromosome partitioning
BVV18_RS19845	COG1475	DNA binding
BVV18_RS19860	COG0463	Glycosyl transferase, family 2
BVV18_RS19885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BVV18_RS19910	COG4221	oxidoreductase activity
BVV18_RS19950	COG1166	arginine decarboxylase activity
BVV18_RS19955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BVV18_RS20000	COG0606	chelatase, subunit chli
BVV18_RS20025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BVV18_RS20045	COG3039	Transposase
BVV18_RS20105	COG1090	epimerase
BVV18_RS20115	COG0642	Histidine kinase
BVV18_RS20130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BVV18_RS20165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BVV18_RS20175	COG1595	DNA-templated transcription, initiation
BVV18_RS20180	COG0753	catalase activity
BVV18_RS20205	COG0697	spore germination
BVV18_RS20230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BVV18_RS20235	COG0180	Tryptophanyl-tRNA synthetase
BVV18_RS20240	COG3237	CsbD-like
BVV18_RS20255	COG0010	Belongs to the arginase family
BVV18_RS20275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BVV18_RS20290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BVV18_RS20295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BVV18_RS20295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BVV18_RS20305	COG3228	Belongs to the MtfA family
BVV18_RS20335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BVV18_RS20390	COG3039	Transposase
BVV18_RS20395	COG1566	PFAM secretion protein HlyD family protein
BVV18_RS20410	COG1199	ATP-dependent helicase activity
BVV18_RS20455	COG0583	DNA-binding transcription factor activity
BVV18_RS20515	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS20545	COG4555	ABC transporter
BVV18_RS20555	COG1476	TRANSCRIPTIONal
BVV18_RS20575	COG1230	cation diffusion facilitator family transporter
BVV18_RS20580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BVV18_RS20585	COG1131	(ABC) transporter
BVV18_RS20590	COG0842	Transport permease protein
BVV18_RS20600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BVV18_RS20655	COG2951	lytic endotransglycosylase activity
BVV18_RS20675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BVV18_RS20685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BVV18_RS20700	COG1042	CoA-binding domain protein
BVV18_RS20700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BVV18_RS20700	COG0045	succinate-CoA ligase (ADP-forming) activity
BVV18_RS20710	COG2239	Acts as a magnesium transporter
BVV18_RS20735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BVV18_RS20740	COG3387	PFAM Glycoside hydrolase 15-related
BVV18_RS20755	COG3100	YcgL domain-containing protein
BVV18_RS20760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BVV18_RS20770	COG0463	Glycosyl transferase, family 2
BVV18_RS20785	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS20815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BVV18_RS20830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BVV18_RS20870	COG0408	coproporphyrinogen oxidase activity
BVV18_RS20950	COG0210	DNA helicase
BVV18_RS20970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BVV18_RS20985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BVV18_RS21000	COG2159	amidohydrolase
BVV18_RS21030	COG0357	Ribosomal RNA small subunit methyltransferase G
BVV18_RS21035	COG3540	Alkaline phosphatase
BVV18_RS21045	COG2091	lysine biosynthetic process via aminoadipic acid
BVV18_RS21060	COG0708	Exodeoxyribonuclease III
BVV18_RS21075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BVV18_RS21080	COG3162	membrane
BVV18_RS21135	COG1028	Short-chain dehydrogenase reductase Sdr
BVV18_RS21140	COG0179	Fumarylacetoacetate (FAA) hydrolase
BVV18_RS21150	COG4948	Mandelate Racemase Muconate Lactonizing
BVV18_RS21160	COG3039	Transposase
BVV18_RS21165	COG3254	rhamnose metabolic process
BVV18_RS21170	COG0738	Major facilitator superfamily
BVV18_RS21175	COG1414	Transcriptional regulator
BVV18_RS21185	COG2205	protein histidine kinase activity
BVV18_RS21195	COG3459	Glycosyltransferase 36 associated
BVV18_RS21200	COG2211	Major facilitator Superfamily
BVV18_RS21205	COG3265	gluconokinase activity
BVV18_RS21210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BVV18_RS21245	COG3039	Transposase
BVV18_RS21255	COG3039	Transposase
BVV18_RS21260	COG2911	Protein conserved in bacteria
BVV18_RS21265	COG0729	surface antigen
BVV18_RS21270	COG4771	TonB-dependent receptor
BVV18_RS21275	COG0457	Tetratricopeptide repeat
BVV18_RS21285	COG0752	glycyl-tRNA synthetase alpha subunit
BVV18_RS21290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BVV18_RS21305	COG0519	Catalyzes the synthesis of GMP from XMP
BVV18_RS21305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BVV18_RS21315	COG0805	protein transport
BVV18_RS21320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BVV18_RS21325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BVV18_RS21335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BVV18_RS21365	COG2974	May be involved in recombination
BVV18_RS21370	COG0037	tRNA processing
BVV18_RS21390	COG3661	Belongs to the glycosyl hydrolase 67 family
BVV18_RS21400	COG4948	Mandelate Racemase Muconate Lactonizing
BVV18_RS21410	COG1472	Belongs to the glycosyl hydrolase 3 family
BVV18_RS21415	COG0246	Mannitol dehydrogenase
BVV18_RS21450	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS21475	COG3693	PFAM glycoside hydrolase, family 10
BVV18_RS21500	COG2211	Major facilitator Superfamily
BVV18_RS21515	COG3039	Transposase
BVV18_RS21550	COG2937	Belongs to the GPAT DAPAT family
BVV18_RS21595	COG0284	orotidine-5'-phosphate decarboxylase activity
BVV18_RS21600	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BVV18_RS21605	COG3132	Protein of unknown function, DUF480
BVV18_RS21620	COG0210	DNA helicase
BVV18_RS21635	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BVV18_RS21645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BVV18_RS21700	COG0676	glucose-6-phosphate 1-epimerase activity
BVV18_RS21715	COG0730	response to heat
BVV18_RS21750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BVV18_RS21755	COG0302	gtp cyclohydrolase
BVV18_RS21785	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS21795	COG0477	Major facilitator Superfamily
BVV18_RS21810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BVV18_RS21855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BVV18_RS21915	COG3237	CsbD-like
BVV18_RS21950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BVV18_RS21980	COG1304	FMN binding
BVV18_RS22005	COG4772	TonB-dependent receptor
BVV18_RS22015	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BVV18_RS22045	COG3039	Transposase
BVV18_RS22095	COG0564	pseudouridine synthase activity
BVV18_RS22110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BVV18_RS22145	COG3039	Transposase
BVV18_RS22165	COG2826	transposase and inactivated derivatives, IS30 family
BVV18_RS22235	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BVV18_RS22250	COG3039	Transposase
BVV18_RS22255	COG3039	Transposase
BVV18_RS22265	COG1136	(ABC) transporter
BVV18_RS22285	COG1127	ABC transporter
BVV18_RS22290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BVV18_RS22295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BVV18_RS22310	COG2853	Lipoprotein
BVV18_RS22325	COG0386	Belongs to the glutathione peroxidase family
BVV18_RS22335	COG1322	Protein conserved in bacteria
BVV18_RS22340	COG3039	Transposase
BVV18_RS22365	COG1929	Belongs to the glycerate kinase type-1 family
BVV18_RS22370	COG2271	Major facilitator Superfamily
BVV18_RS22385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BVV18_RS22395	COG0861	Integral membrane protein TerC family
BVV18_RS22410	COG0584	glycerophosphoryl diester phosphodiesterase
BVV18_RS22420	COG0671	phosphoesterase, PA-phosphatase related
BVV18_RS22425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BVV18_RS22430	COG0726	polysaccharide deacetylase