locus-tag	class	description
EBA21_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EBA21_RS00030	COG0187	DNA topoisomerase II activity
EBA21_RS00040	COG0501	Belongs to the peptidase M48B family
EBA21_RS00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EBA21_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA21_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EBA21_RS00100	COG4772	TonB-dependent receptor
EBA21_RS00115	COG3039	Transposase
EBA21_RS00120	COG1304	FMN binding
EBA21_RS00140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EBA21_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA21_RS00250	COG2826	transposase and inactivated derivatives, IS30 family
EBA21_RS00275	COG3039	Transposase
EBA21_RS00285	COG1090	epimerase
EBA21_RS00295	COG0642	Histidine kinase
EBA21_RS00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBA21_RS00410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EBA21_RS00500	COG1511	domain protein
EBA21_RS00500	COG3264	Mechanosensitive ion channel
EBA21_RS00515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EBA21_RS00525	COG2354	Protein conserved in bacteria
EBA21_RS00530	COG1649	PFAM Uncharacterised BCR, COG1649
EBA21_RS00550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EBA21_RS00575	COG0702	epimerase
EBA21_RS00590	COG1858	cytochrome C peroxidase
EBA21_RS00675	COG0513	Belongs to the DEAD box helicase family
EBA21_RS00685	COG3039	Transposase
EBA21_RS00735	COG1136	(ABC) transporter
EBA21_RS00765	COG1136	(ABC) transporter
EBA21_RS00810	COG1272	protein, Hemolysin III
EBA21_RS00815	COG1111	helicase
EBA21_RS00815	COG1205	dead DEAH box helicase
EBA21_RS00875	COG0067	glutamate synthase
EBA21_RS00875	COG0070	glutamate synthase
EBA21_RS00875	COG0069	glutamate synthase activity
EBA21_RS00880	COG0493	'glutamate synthase
EBA21_RS00925	COG1609	Transcriptional regulator
EBA21_RS00960	COG0366	Alpha amylase catalytic
EBA21_RS00965	COG0366	Alpha amylase catalytic
EBA21_RS01015	COG0606	chelatase, subunit chli
EBA21_RS01065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EBA21_RS01070	COG1166	arginine decarboxylase activity
EBA21_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EBA21_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS01175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EBA21_RS01190	COG0210	DNA helicase
EBA21_RS01205	COG3132	Protein of unknown function, DUF480
EBA21_RS01210	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EBA21_RS01215	COG0284	orotidine-5'-phosphate decarboxylase activity
EBA21_RS01250	COG2937	Belongs to the GPAT DAPAT family
EBA21_RS01290	COG1752	Esterase of the alpha-beta hydrolase superfamily
EBA21_RS01300	COG1119	ATPase activity
EBA21_RS01315	COG1125	glycine betaine transport
EBA21_RS01315	COG0517	IMP dehydrogenase activity
EBA21_RS01330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EBA21_RS01335	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EBA21_RS01340	COG3550	peptidyl-serine autophosphorylation
EBA21_RS01345	COG1396	sequence-specific DNA binding
EBA21_RS01365	COG0489	protein tyrosine kinase activity
EBA21_RS01370	COG2062	phosphohistidine phosphatase, SixA
EBA21_RS01380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA21_RS01425	COG1968	undecaprenyl-diphosphatase activity
EBA21_RS01430	COG0174	glutamine synthetase
EBA21_RS01435	COG0347	Belongs to the P(II) protein family
EBA21_RS01440	COG0004	ammonium transporteR
EBA21_RS01445	COG3852	Histidine kinase
EBA21_RS01450	COG2204	response regulator
EBA21_RS01455	COG2032	superoxide dismutase activity
EBA21_RS01460	COG2032	superoxide dismutase activity
EBA21_RS01495	COG1196	nuclear chromosome segregation
EBA21_RS01505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EBA21_RS01510	COG1074	ATP-dependent DNA helicase activity
EBA21_RS01520	COG3549	Plasmid maintenance system killer
EBA21_RS01610	COG1764	response to oxidative stress
EBA21_RS01615	COG1846	Transcriptional regulator
EBA21_RS01655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EBA21_RS01695	COG2211	Major facilitator Superfamily
EBA21_RS01720	COG3693	PFAM glycoside hydrolase, family 10
EBA21_RS01745	COG0246	Mannitol dehydrogenase
EBA21_RS01750	COG1472	Belongs to the glycosyl hydrolase 3 family
EBA21_RS01760	COG4948	Mandelate Racemase Muconate Lactonizing
EBA21_RS01770	COG3661	Belongs to the glycosyl hydrolase 67 family
EBA21_RS01790	COG0037	tRNA processing
EBA21_RS01795	COG2974	May be involved in recombination
EBA21_RS01820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EBA21_RS01830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBA21_RS01840	COG0805	protein transport
EBA21_RS01850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EBA21_RS01850	COG0519	Catalyzes the synthesis of GMP from XMP
EBA21_RS01875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EBA21_RS01880	COG0752	glycyl-tRNA synthetase alpha subunit
EBA21_RS01890	COG0457	Tetratricopeptide repeat
EBA21_RS01895	COG4771	TonB-dependent receptor
EBA21_RS01920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EBA21_RS01930	COG0697	spore germination
EBA21_RS01940	COG0523	cobalamin synthesis protein
EBA21_RS01990	COG1960	acyl-CoA dehydrogenase activity
EBA21_RS01995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EBA21_RS02000	COG4770	biotin carboxylase activity
EBA21_RS02055	COG2072	flavoprotein involved in K transport
EBA21_RS02075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EBA21_RS02120	COG0084	hydrolase, TatD family'
EBA21_RS02140	COG0583	DNA-binding transcription factor activity
EBA21_RS02165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EBA21_RS02170	COG1902	pentaerythritol trinitrate reductase activity
EBA21_RS02200	COG0745	RESPONSE REGULATOR receiver
EBA21_RS02220	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EBA21_RS02225	COG0583	DNA-binding transcription factor activity
EBA21_RS02255	COG0702	epimerase
EBA21_RS02260	COG1733	regulation of RNA biosynthetic process
EBA21_RS02310	COG3039	Transposase
EBA21_RS02330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EBA21_RS02345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBA21_RS02380	COG2911	Protein conserved in bacteria
EBA21_RS02385	COG0729	surface antigen
EBA21_RS02400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EBA21_RS02405	COG3118	belongs to the thioredoxin family
EBA21_RS02415	COG2884	Cell division ATP-binding protein ftsE
EBA21_RS02420	COG2177	Part of the ABC transporter FtsEX involved in
EBA21_RS02425	COG3437	response regulator, receiver
EBA21_RS02430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EBA21_RS02435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EBA21_RS02445	COG1252	NADH dehydrogenase
EBA21_RS02470	COG0459	protein refolding
EBA21_RS02480	COG4771	TonB-dependent receptor
EBA21_RS02495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EBA21_RS02540	COG3386	PFAM SMP-30 Gluconolaconase
EBA21_RS02555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EBA21_RS02585	COG2353	YceI-like domain
EBA21_RS02695	COG0408	coproporphyrinogen oxidase activity
EBA21_RS02705	COG3039	Transposase
EBA21_RS02730	COG0129	dihydroxy-acid dehydratase activity
EBA21_RS02740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EBA21_RS02775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EBA21_RS02780	COG0318	PFAM AMP-dependent synthetase and ligase
EBA21_RS02785	COG0727	PFAM Uncharacterised protein family (UPF0153)
EBA21_RS02790	COG0596	Alpha beta hydrolase
EBA21_RS02805	COG3177	Filamentation induced by cAMP protein fic
EBA21_RS02810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBA21_RS02825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EBA21_RS02850	COG4191	Histidine kinase
EBA21_RS02855	COG0028	Belongs to the TPP enzyme family
EBA21_RS02870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EBA21_RS02875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBA21_RS02905	COG5383	Protein conserved in bacteria
EBA21_RS02920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA21_RS02925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA21_RS02930	COG1473	amidohydrolase
EBA21_RS02940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EBA21_RS02940	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EBA21_RS02955	COG3328	transposase activity
EBA21_RS02980	COG3039	Transposase
EBA21_RS03055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EBA21_RS03070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBA21_RS03075	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EBA21_RS03085	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EBA21_RS03090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EBA21_RS03095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EBA21_RS03145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EBA21_RS03160	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EBA21_RS03220	COG3039	Transposase
EBA21_RS03245	COG1271	oxidase subunit
EBA21_RS03305	COG2972	Histidine kinase
EBA21_RS03330	COG0531	amino acid
EBA21_RS03350	COG3590	peptidase
EBA21_RS03360	COG0667	Aldo Keto reductase
EBA21_RS03375	COG3384	dioxygenase
EBA21_RS03385	COG1573	uracil-dna glycosylase
EBA21_RS03395	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EBA21_RS03410	COG0025	NhaP-type Na H and K H
EBA21_RS03415	COG1131	(ABC) transporter
EBA21_RS03420	COG0842	Transport permease protein
EBA21_RS03435	COG1404	Belongs to the peptidase S8 family
EBA21_RS03450	COG0745	RESPONSE REGULATOR receiver
EBA21_RS03500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA21_RS03525	COG2202	Pas domain
EBA21_RS03525	COG2205	protein histidine kinase activity
EBA21_RS03555	COG2813	Specifically methylates the guanine in position
EBA21_RS03560	COG1187	pseudouridine synthase activity
EBA21_RS03565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EBA21_RS03605	COG0697	spore germination
EBA21_RS03615	COG2011	ABC-type metal ion transport system permease component
EBA21_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBA21_RS03655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBA21_RS03675	COG0356	it plays a direct role in the translocation of protons across the membrane
EBA21_RS03685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EBA21_RS03695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EBA21_RS03700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EBA21_RS03705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EBA21_RS03760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA21_RS03765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBA21_RS03815	COG0339	signal peptide processing
EBA21_RS03855	COG1956	GAF domain-containing protein
EBA21_RS03860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EBA21_RS03870	COG0720	synthase
EBA21_RS03880	COG0513	Belongs to the DEAD box helicase family
EBA21_RS03895	COG0625	glutathione transferase activity
EBA21_RS03925	COG0626	cystathionine gamma-synthase activity
EBA21_RS03945	COG1216	Glycosyl transferase, family 2
EBA21_RS03945	COG0438	transferase activity, transferring glycosyl groups
EBA21_RS03980	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EBA21_RS03985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EBA21_RS04000	COG0277	FAD linked oxidase domain protein
EBA21_RS04005	COG0546	phosphoglycolate phosphatase activity
EBA21_RS04005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EBA21_RS04020	COG2086	electron transfer activity
EBA21_RS04045	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EBA21_RS04045	COG0662	Cupin 2, conserved barrel domain protein
EBA21_RS04050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBA21_RS04090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EBA21_RS04090	COG3218	ABC-type transport auxiliary lipoprotein component
EBA21_RS04095	COG1127	ABC transporter
EBA21_RS04100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EBA21_RS04115	COG0442	prolyl-tRNA aminoacylation
EBA21_RS04125	COG1183	phosphatidylcholine synthase activity
EBA21_RS04160	COG3039	Transposase
EBA21_RS04185	COG3039	Transposase
EBA21_RS04215	COG0525	valine-tRNA ligase activity
EBA21_RS04230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EBA21_RS04240	COG0795	lipopolysaccharide-transporting ATPase activity
EBA21_RS04255	COG4974	Belongs to the 'phage' integrase family
EBA21_RS04260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EBA21_RS04265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EBA21_RS04265	COG0047	phosphoribosylformylglycinamidine synthase activity
EBA21_RS04275	COG5295	Hep Hag repeat protein
EBA21_RS04285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EBA21_RS04295	COG1459	type II secretion system
EBA21_RS04300	COG2165	general secretion pathway protein
EBA21_RS04305	COG4970	Tfp pilus assembly protein FimT
EBA21_RS04310	COG2165	general secretion pathway protein
EBA21_RS04315	COG4795	General secretion pathway protein
EBA21_RS04320	COG3156	type II secretion system protein K
EBA21_RS04325	COG3166	PFAM Fimbrial assembly family protein
EBA21_RS04340	COG1450	Type ii and iii secretion system protein
EBA21_RS04355	COG2188	Transcriptional regulator
EBA21_RS04410	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EBA21_RS04415	COG1518	maintenance of DNA repeat elements
EBA21_RS04460	COG1399	metal-binding, possibly nucleic acid-binding protein
EBA21_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS04490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EBA21_RS04500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EBA21_RS04505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EBA21_RS04540	COG3829	transcription factor binding
EBA21_RS04640	COG2826	transposase and inactivated derivatives, IS30 family
EBA21_RS04650	COG0678	peroxiredoxin activity
EBA21_RS04670	COG0330	HflC and HflK could
EBA21_RS04675	COG0330	HflC and HflK could
EBA21_RS04685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EBA21_RS04690	COG0308	aminopeptidase N
EBA21_RS04745	COG1560	Kdo2-lipid A biosynthetic process
EBA21_RS04750	COG1519	Transferase
EBA21_RS04755	COG1538	Outer membrane efflux protein
EBA21_RS04760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBA21_RS04790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EBA21_RS04795	COG0066	3-isopropylmalate dehydratase activity
EBA21_RS04830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EBA21_RS04840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EBA21_RS04845	COG3710	Transcriptional regulator
EBA21_RS04870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EBA21_RS04890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EBA21_RS04920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBA21_RS04930	COG3781	membrane
EBA21_RS05100	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EBA21_RS05120	COG1217	gtp-binding protein TYPA
EBA21_RS05125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EBA21_RS05130	COG0039	L-malate dehydrogenase activity
EBA21_RS05135	COG0625	glutathione transferase activity
EBA21_RS05170	COG3039	Transposase
EBA21_RS05195	COG0584	glycerophosphoryl diester phosphodiesterase
EBA21_RS05225	COG0446	pyridine nucleotide-disulphide oxidoreductase
EBA21_RS05225	COG1902	pentaerythritol trinitrate reductase activity
EBA21_RS05230	COG0604	alcohol dehydrogenase
EBA21_RS05260	COG0156	8-amino-7-oxononanoate synthase activity
EBA21_RS05265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EBA21_RS05270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EBA21_RS05280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EBA21_RS05315	COG0588	phosphoglycerate mutase activity
EBA21_RS05325	COG0285	dihydrofolate synthase activity
EBA21_RS05345	COG2833	Protein of unknown function (DUF455)
EBA21_RS05365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBA21_RS05370	COG0671	phosphoesterase, PA-phosphatase related
EBA21_RS05375	COG0438	transferase activity, transferring glycosyl groups
EBA21_RS05385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EBA21_RS05400	COG4783	chaperone-mediated protein folding
EBA21_RS05425	COG0473	3-isopropylmalate dehydrogenase activity
EBA21_RS05480	COG0544	peptidyl-prolyl cis-trans isomerase activity
EBA21_RS05520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBA21_RS05545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EBA21_RS05555	COG0631	protein serine/threonine phosphatase activity
EBA21_RS05610	COG0582	viral genome integration into host DNA
EBA21_RS05620	COG0859	PFAM glycosyl transferase family 9
EBA21_RS05625	COG3642	lipopolysaccharide core region biosynthetic process
EBA21_RS05630	COG1234	tRNA 3'-trailer cleavage
EBA21_RS05635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EBA21_RS05645	COG0315	cyclic pyranopterin monophosphate synthase activity
EBA21_RS05650	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EBA21_RS05655	COG0314	molybdopterin synthase activity
EBA21_RS05685	COG0537	adenosine 5'-monophosphoramidase activity
EBA21_RS05705	COG0714	Associated with various cellular activities
EBA21_RS05725	COG0242	peptide deformylase activity
EBA21_RS05780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EBA21_RS05785	COG0726	polysaccharide deacetylase
EBA21_RS05810	COG1162	GTPase activity
EBA21_RS05835	COG2211	Major facilitator Superfamily
EBA21_RS05850	COG1609	Transcriptional regulator
EBA21_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS05860	COG2851	Citrate transporter
EBA21_RS05880	COG0642	Histidine kinase
EBA21_RS05890	COG2197	response regulator
EBA21_RS05910	COG0583	DNA-binding transcription factor activity
EBA21_RS05925	COG4191	Histidine kinase
EBA21_RS05945	COG0281	malic enzyme
EBA21_RS05945	COG0280	phosphate acetyltransferase
EBA21_RS06010	COG0352	thiamine-phosphate diphosphorylase activity
EBA21_RS06015	COG1773	rubredoxin
EBA21_RS06020	COG2912	Transglutaminase-like superfamily
EBA21_RS06030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EBA21_RS06065	COG0006	proline dipeptidase activity
EBA21_RS06095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EBA21_RS06110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EBA21_RS06115	COG1561	YicC-like family, N-terminal region
EBA21_RS06140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EBA21_RS06150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EBA21_RS06175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EBA21_RS06225	COG0714	Associated with various cellular activities
EBA21_RS06245	COG2304	oxidoreductase activity
EBA21_RS06265	COG1301	dicarboxylic acid transport
EBA21_RS06270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EBA21_RS06280	COG0739	heme binding
EBA21_RS06285	COG1376	ErfK ybiS ycfS ynhG family protein
EBA21_RS06315	COG1022	Amp-dependent synthetase and ligase
EBA21_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS06340	COG0642	Histidine kinase
EBA21_RS06360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EBA21_RS06365	COG4149	molybdate abc transporter
EBA21_RS06370	COG0725	ABC transporter, periplasmic molybdate-binding protein
EBA21_RS06375	COG3453	Protein conserved in bacteria
EBA21_RS06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBA21_RS06410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EBA21_RS06430	COG2205	protein histidine kinase activity
EBA21_RS06435	COG0745	RESPONSE REGULATOR receiver
EBA21_RS06460	COG3039	Transposase
EBA21_RS06495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBA21_RS06500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EBA21_RS06550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EBA21_RS06610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBA21_RS06630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EBA21_RS06645	COG1595	DNA-templated transcription, initiation
EBA21_RS06695	COG2244	polysaccharide biosynthetic process
EBA21_RS06725	COG2264	protein methyltransferase activity
EBA21_RS06735	COG0438	transferase activity, transferring glycosyl groups
EBA21_RS06750	COG1136	(ABC) transporter
EBA21_RS06755	COG1132	(ABC) transporter
EBA21_RS06765	COG0477	Major facilitator Superfamily
EBA21_RS06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EBA21_RS06800	COG1253	flavin adenine dinucleotide binding
EBA21_RS06815	COG0306	phosphate transporter
EBA21_RS06845	COG0504	CTP synthase activity
EBA21_RS06850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EBA21_RS06860	COG0148	phosphopyruvate hydratase activity
EBA21_RS06865	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EBA21_RS06870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EBA21_RS06880	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EBA21_RS06890	COG2840	Smr protein MutS2
EBA21_RS06895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EBA21_RS06900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBA21_RS06905	COG1238	metal cluster binding
EBA21_RS06920	COG1534	Rna-binding protein
EBA21_RS06925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EBA21_RS06935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EBA21_RS06940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EBA21_RS06950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EBA21_RS06955	COG1546	Belongs to the CinA family
EBA21_RS06970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EBA21_RS06975	COG2137	regulation of response to DNA damage stimulus
EBA21_RS06980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EBA21_RS06985	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EBA21_RS07010	COG0305	Participates in initiation and elongation during chromosome replication
EBA21_RS07015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EBA21_RS07040	COG1741	Belongs to the pirin family
EBA21_RS07045	COG0583	DNA-binding transcription factor activity
EBA21_RS07075	COG0351	phosphomethylpyrimidine kinase
EBA21_RS07085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EBA21_RS07090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EBA21_RS07105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBA21_RS07115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EBA21_RS07120	COG3734	2-keto-3-deoxy-galactonokinase
EBA21_RS07130	COG4948	Mandelate Racemase Muconate Lactonizing
EBA21_RS07135	COG0800	Aldolase
EBA21_RS07150	COG1501	Belongs to the glycosyl hydrolase 31 family
EBA21_RS07160	COG1070	Carbohydrate kinase
EBA21_RS07170	COG0477	Major facilitator Superfamily
EBA21_RS07190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EBA21_RS07240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EBA21_RS07245	COG2258	MOSC domain
EBA21_RS07255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EBA21_RS07260	COG0505	Belongs to the CarA family
EBA21_RS07270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EBA21_RS07275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBA21_RS07285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EBA21_RS07345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EBA21_RS07360	COG2198	Histidine kinase
EBA21_RS07360	COG0784	Response regulator, receiver
EBA21_RS07360	COG2205	protein histidine kinase activity
EBA21_RS07365	COG1024	Enoyl-CoA hydratase
EBA21_RS07370	COG0318	PFAM AMP-dependent synthetase and ligase
EBA21_RS07400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EBA21_RS07460	COG0835	chemotaxis
EBA21_RS07480	COG0840	transmembrane signaling receptor activity
EBA21_RS07485	COG0840	transmembrane signaling receptor activity
EBA21_RS07490	COG0840	transmembrane signaling receptor activity
EBA21_RS07495	COG0840	transmembrane signaling receptor activity
EBA21_RS07505	COG0840	transmembrane signaling receptor activity
EBA21_RS07520	COG0840	transmembrane signaling receptor activity
EBA21_RS07535	COG0840	transmembrane signaling receptor activity
EBA21_RS07560	COG0745	RESPONSE REGULATOR receiver
EBA21_RS07570	COG0835	chemotaxis
EBA21_RS07580	COG1360	Flagellar Motor Protein
EBA21_RS07585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EBA21_RS07605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EBA21_RS07615	COG4771	TonB-dependent receptor
EBA21_RS07630	COG1192	Involved in chromosome partitioning
EBA21_RS07670	COG3039	Transposase
EBA21_RS07760	COG3039	Transposase
EBA21_RS07800	COG0343	queuine tRNA-ribosyltransferase activity
EBA21_RS07805	COG1862	Preprotein translocase
EBA21_RS07810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBA21_RS07815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBA21_RS07845	COG3328	transposase activity
EBA21_RS07860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EBA21_RS07870	COG0704	Plays a role in the regulation of phosphate uptake
EBA21_RS07885	COG0573	inorganic phosphate transmembrane transporter activity
EBA21_RS07890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EBA21_RS07925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EBA21_RS07945	COG0494	nUDIX hydrolase
EBA21_RS07990	COG0116	Belongs to the methyltransferase superfamily
EBA21_RS07990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBA21_RS08015	COG0667	Aldo Keto reductase
EBA21_RS08025	COG2925	Exonuclease
EBA21_RS08055	COG0288	reversible hydration of carbon dioxide
EBA21_RS08090	COG0316	Belongs to the HesB IscA family
EBA21_RS08095	COG0360	Binds together with S18 to 16S ribosomal RNA
EBA21_RS08105	COG0359	binds to the 23S rRNA
EBA21_RS08115	COG3115	cell septum assembly
EBA21_RS08130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EBA21_RS08145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EBA21_RS08170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EBA21_RS08180	COG2986	histidine ammonia-lyase
EBA21_RS08185	COG1228	amidohydrolase
EBA21_RS08235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EBA21_RS08245	COG0077	Prephenate dehydratase
EBA21_RS08245	COG1605	Chorismate mutase
EBA21_RS08250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EBA21_RS08280	COG4566	intracellular signal transduction
EBA21_RS08335	COG0860	N-Acetylmuramoyl-L-alanine amidase
EBA21_RS08340	COG1469	GTP cyclohydrolase I activity
EBA21_RS08350	COG0617	tRNA 3'-terminal CCA addition
EBA21_RS08360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EBA21_RS08365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EBA21_RS08400	COG1472	Belongs to the glycosyl hydrolase 3 family
EBA21_RS08420	COG5001	Diguanylate cyclase
EBA21_RS08420	COG2203	Gaf domain
EBA21_RS08420	COG3706	GGDEF domain
EBA21_RS08420	COG4251	negative regulation of phosphorylation
EBA21_RS08510	COG0386	Belongs to the glutathione peroxidase family
EBA21_RS08595	COG1247	-acetyltransferase
EBA21_RS08615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EBA21_RS08645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBA21_RS08660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBA21_RS08665	COG1393	Belongs to the ArsC family
EBA21_RS08670	COG0431	NADPH-dependent FMN reductase
EBA21_RS08675	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EBA21_RS08680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBA21_RS08705	COG0784	Response regulator, receiver
EBA21_RS08705	COG2205	protein histidine kinase activity
EBA21_RS08705	COG5002	protein histidine kinase activity
EBA21_RS08740	COG0800	Aldolase
EBA21_RS08745	COG0129	dihydroxy-acid dehydratase activity
EBA21_RS08750	COG0363	glucosamine-6-phosphate deaminase activity
EBA21_RS08760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EBA21_RS08775	COG0354	folic acid binding
EBA21_RS08790	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EBA21_RS08805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EBA21_RS08820	COG4591	ABC-type transport system involved in lipoprotein release permease component
EBA21_RS08845	COG0811	peptide transport
EBA21_RS08860	COG1663	tetraacyldisaccharide 4'-kinase activity
EBA21_RS08870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBA21_RS08880	COG0322	excinuclease ABC activity
EBA21_RS08930	COG2801	Transposase and inactivated derivatives
EBA21_RS08940	COG2201	protein-glutamate methylesterase activity
EBA21_RS08985	COG0653	protein targeting
EBA21_RS09145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EBA21_RS09145	COG0140	phosphoribosyl-ATP diphosphatase activity
EBA21_RS09155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EBA21_RS09165	COG0131	Imidazoleglycerol-phosphate dehydratase
EBA21_RS09165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EBA21_RS09180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EBA21_RS09210	COG0124	histidyl-tRNA synthetase
EBA21_RS09230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EBA21_RS09275	COG1012	belongs to the aldehyde dehydrogenase family
EBA21_RS09300	COG0697	spore germination
EBA21_RS09310	COG1794	racemase activity, acting on amino acids and derivatives
EBA21_RS09335	COG0671	phosphoesterase, PA-phosphatase related
EBA21_RS09350	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EBA21_RS09365	COG2183	response to ionizing radiation
EBA21_RS09375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA21_RS09375	COG0723	plastoquinol--plastocyanin reductase activity
EBA21_RS09390	COG3243	poly(R)-hydroxyalkanoic acid synthase
EBA21_RS09400	COG1183	phosphatidylcholine synthase activity
EBA21_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS09430	COG0668	transmembrane transport
EBA21_RS09450	COG1914	H( )-stimulated, divalent metal cation uptake system
EBA21_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS09500	COG0583	DNA-binding transcription factor activity
EBA21_RS09505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EBA21_RS09510	COG3002	Belongs to the UPF0753 family
EBA21_RS09525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EBA21_RS09555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EBA21_RS09565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBA21_RS09570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EBA21_RS09580	COG0776	regulation of translation
EBA21_RS09585	COG0539	negative regulation of cytoplasmic translation
EBA21_RS09590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EBA21_RS09605	COG2957	Belongs to the agmatine deiminase family
EBA21_RS09615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBA21_RS09640	COG0395	ABC-type sugar transport system, permease component
EBA21_RS09645	COG1175	transmembrane transport
EBA21_RS09675	COG2350	Protein conserved in bacteria
EBA21_RS09680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EBA21_RS09685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EBA21_RS09690	COG1187	pseudouridine synthase activity
EBA21_RS09715	COG0436	Aminotransferase
EBA21_RS09720	COG4133	protoheme IX ABC transporter activity
EBA21_RS09780	COG0277	FAD linked oxidase domain protein
EBA21_RS09785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EBA21_RS09795	COG0531	amino acid
EBA21_RS09800	COG0531	amino acid
EBA21_RS09810	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EBA21_RS09840	COG3039	Transposase
EBA21_RS09850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EBA21_RS09925	COG0303	'Molybdopterin
EBA21_RS09935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA21_RS09955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EBA21_RS09970	COG1024	Enoyl-CoA hydratase
EBA21_RS09970	COG1250	3-hydroxyacyl-CoA dehydrogenase
EBA21_RS09975	COG0183	Belongs to the thiolase family
EBA21_RS09985	COG0038	chloride channel
EBA21_RS10005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EBA21_RS10030	COG1674	ftsk spoiiie
EBA21_RS10035	COG0492	ferredoxin-NADP+ reductase activity
EBA21_RS10060	COG0542	response to heat
EBA21_RS10075	COG0482	sulfurtransferase activity
EBA21_RS10100	COG5001	Diguanylate cyclase
EBA21_RS10105	COG4585	Histidine kinase
EBA21_RS10115	COG5002	protein histidine kinase activity
EBA21_RS10135	COG0835	chemotaxis
EBA21_RS10135	COG0784	Response regulator, receiver
EBA21_RS10145	COG1558	bacterial-type flagellum-dependent cell motility
EBA21_RS10150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EBA21_RS10160	COG4787	bacterial-type flagellum-dependent cell motility
EBA21_RS10200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EBA21_RS10205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EBA21_RS10235	COG2201	protein-glutamate methylesterase activity
EBA21_RS10255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBA21_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS10300	COG1677	Flagellar hook-basal body complex protein FliE
EBA21_RS10350	COG3190	flagellar
EBA21_RS10370	COG1684	flagellar biosynthetic protein fliR
EBA21_RS10425	COG0784	Response regulator, receiver
EBA21_RS10425	COG2198	Histidine kinase
EBA21_RS10425	COG0643	Histidine kinase
EBA21_RS10455	COG3039	Transposase
EBA21_RS10465	COG3209	COG3209 Rhs family protein
EBA21_RS10565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EBA21_RS10570	COG4988	ABC transporter
EBA21_RS10615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EBA21_RS10635	COG0165	Argininosuccinate lyase
EBA21_RS10650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBA21_RS10655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBA21_RS10665	COG0137	argininosuccinate synthase activity
EBA21_RS10670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EBA21_RS10690	COG2166	iron-sulfur cluster assembly
EBA21_RS10715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EBA21_RS10750	COG3039	Transposase
EBA21_RS10770	COG4677	pectinesterase activity
EBA21_RS10795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EBA21_RS10800	COG0402	S-adenosylhomocysteine deaminase activity
EBA21_RS10815	COG1509	lysine 2,3-aminomutase activity
EBA21_RS10820	COG3300	MHYT domain
EBA21_RS10820	COG5001	Diguanylate cyclase
EBA21_RS10835	COG0483	inositol monophosphate 1-phosphatase activity
EBA21_RS10840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EBA21_RS10865	COG0488	(ABC) transporter
EBA21_RS10870	COG0513	Belongs to the DEAD box helicase family
EBA21_RS10875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EBA21_RS10880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EBA21_RS10890	COG0625	glutathione transferase activity
EBA21_RS10900	COG1671	Belongs to the UPF0178 family
EBA21_RS10905	COG4681	YaeQ
EBA21_RS10910	COG2081	HI0933 family
EBA21_RS10920	COG0501	Belongs to the peptidase M48B family
EBA21_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS10955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EBA21_RS10960	COG0860	N-Acetylmuramoyl-L-alanine amidase
EBA21_RS10965	COG0802	atpase or kinase
EBA21_RS10970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EBA21_RS10970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EBA21_RS10975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EBA21_RS10995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EBA21_RS11085	COG3328	transposase activity
EBA21_RS11130	COG2969	positive regulation of protein catabolic process
EBA21_RS11135	COG0625	glutathione transferase activity
EBA21_RS11140	COG2857	Cytochrome c1
EBA21_RS11145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EBA21_RS11150	COG0723	plastoquinol--plastocyanin reductase activity
EBA21_RS11160	COG0741	lytic transglycosylase activity
EBA21_RS11185	COG1702	phosphate starvation-inducible protein PhoH
EBA21_RS11205	COG4535	Mg2 and Co2 transporter CorC
EBA21_RS11220	COG1012	belongs to the aldehyde dehydrogenase family
EBA21_RS11230	COG1177	transmembrane transport
EBA21_RS11240	COG3842	ATPase activity
EBA21_RS11285	COG0174	glutamine synthetase
EBA21_RS11290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA21_RS11300	COG0477	Major facilitator Superfamily
EBA21_RS11310	COG0243	molybdopterin cofactor binding
EBA21_RS11320	COG2223	nitrite transmembrane transporter activity
EBA21_RS11330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EBA21_RS11335	COG1121	(ABC) transporter
EBA21_RS11345	COG2733	membrane
EBA21_RS11350	COG0784	Response regulator, receiver
EBA21_RS11350	COG2205	protein histidine kinase activity
EBA21_RS11350	COG5002	protein histidine kinase activity
EBA21_RS11360	COG3039	Transposase
EBA21_RS11370	COG2902	Dehydrogenase
EBA21_RS11380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA21_RS11385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA21_RS11405	COG1609	Transcriptional regulator
EBA21_RS11410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBA21_RS11410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBA21_RS11415	COG1105	Belongs to the carbohydrate kinase PfkB family
EBA21_RS11420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EBA21_RS11420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EBA21_RS11435	COG3039	Transposase
EBA21_RS11445	COG3039	Transposase
EBA21_RS11605	COG0405	Gamma-glutamyltransferase
EBA21_RS11610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EBA21_RS11625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EBA21_RS11630	COG0742	ribosomal rna small subunit methyltransferase
EBA21_RS11730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA21_RS11735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBA21_RS11790	COG1858	cytochrome C peroxidase
EBA21_RS11820	COG0515	serine threonine protein kinase
EBA21_RS11825	COG0631	protein serine/threonine phosphatase activity
EBA21_RS11945	COG3039	Transposase
EBA21_RS11995	COG3039	Transposase
EBA21_RS12020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EBA21_RS12020	COG0316	Belongs to the HesB IscA family
EBA21_RS12025	COG2154	pterin-4-alpha-carbinolamine dehydratase
EBA21_RS12035	COG0428	transporter
EBA21_RS12040	COG0428	transporter
EBA21_RS12055	COG1530	ribonuclease E activity
EBA21_RS12075	COG1054	Belongs to the UPF0176 family
EBA21_RS12095	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EBA21_RS12130	COG3039	Transposase
EBA21_RS12160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBA21_RS12160	COG1648	precorrin-2 dehydrogenase activity
EBA21_RS12185	COG0746	molybdenum cofactor guanylyltransferase activity
EBA21_RS12215	COG3039	Transposase
EBA21_RS12285	COG4206	TonB-dependent receptor
EBA21_RS12335	COG0531	amino acid
EBA21_RS12350	COG0006	proline dipeptidase activity
EBA21_RS12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBA21_RS12375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA21_RS12380	COG3938	Belongs to the proline racemase family
EBA21_RS12390	COG0552	protein localization to endoplasmic reticulum
EBA21_RS12415	COG4191	Histidine kinase
EBA21_RS12415	COG0784	Response regulator, receiver
EBA21_RS12510	COG3040	lipid binding
EBA21_RS12550	COG0438	transferase activity, transferring glycosyl groups
EBA21_RS12560	COG0438	transferase activity, transferring glycosyl groups
EBA21_RS12565	COG0438	transferase activity, transferring glycosyl groups
EBA21_RS12620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EBA21_RS12625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EBA21_RS12635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EBA21_RS12675	COG0556	nucleotide-excision repair
EBA21_RS12680	COG4969	Belongs to the N-Me-Phe pilin family
EBA21_RS12730	COG1611	Belongs to the LOG family
EBA21_RS12745	COG2095	MarC family integral membrane protein
EBA21_RS12755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EBA21_RS12790	COG1185	polyribonucleotide nucleotidyltransferase activity
EBA21_RS12795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EBA21_RS12815	COG0195	Participates in both transcription termination and antitermination
EBA21_RS12820	COG0779	Required for maturation of 30S ribosomal subunits
EBA21_RS12830	COG1007	ATP synthesis coupled electron transport
EBA21_RS12860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EBA21_RS12865	COG1034	ATP synthesis coupled electron transport
EBA21_RS12870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EBA21_RS12875	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EBA21_RS12880	COG0649	NAD binding
EBA21_RS12885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBA21_RS12895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBA21_RS12910	COG0149	triose-phosphate isomerase activity
EBA21_RS12965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBA21_RS12970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EBA21_RS12980	COG0159	tryptophan synthase activity
EBA21_RS12990	COG0133	tryptophan synthase activity
EBA21_RS13000	COG0135	phosphoribosylanthranilate isomerase activity
EBA21_RS13005	COG0101	tRNA pseudouridine synthase activity
EBA21_RS13025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EBA21_RS13030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EBA21_RS13035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EBA21_RS13040	COG2890	protein-(glutamine-N5) methyltransferase activity
EBA21_RS13170	COG3039	Transposase
EBA21_RS13190	COG3179	chitinase
EBA21_RS13245	COG1741	Belongs to the pirin family
EBA21_RS13250	COG1966	Carbon starvation protein
EBA21_RS13255	COG2879	small protein
EBA21_RS13295	COG4251	negative regulation of phosphorylation
EBA21_RS13295	COG2203	Gaf domain
EBA21_RS13295	COG3706	GGDEF domain
EBA21_RS13295	COG5001	Diguanylate cyclase
EBA21_RS13300	COG0629	single-stranded DNA binding
EBA21_RS13305	COG0142	geranyltranstransferase activity
EBA21_RS13335	COG0527	aspartate kinase activity
EBA21_RS13345	COG0384	phenazine biosynthesis protein PhzF
EBA21_RS13355	COG1764	response to oxidative stress
EBA21_RS13370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EBA21_RS13375	COG1678	Uncharacterized ACR, COG1678
EBA21_RS13385	COG0519	Catalyzes the synthesis of GMP from XMP
EBA21_RS13420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EBA21_RS13460	COG0693	protein deglycase activity
EBA21_RS13480	COG1959	2 iron, 2 sulfur cluster binding
EBA21_RS13485	COG0719	Fe-S assembly protein
EBA21_RS13490	COG0396	ATPase activity
EBA21_RS13495	COG0719	Fe-S assembly protein
EBA21_RS13500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EBA21_RS13510	COG2146	nitrite reductase [NAD(P)H] activity
EBA21_RS13545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EBA21_RS13560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EBA21_RS13570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EBA21_RS13575	COG0174	glutamine synthetase
EBA21_RS13580	COG3328	transposase activity
EBA21_RS13610	COG0326	Molecular chaperone. Has ATPase activity
EBA21_RS13615	COG2207	Transcriptional regulator
EBA21_RS13635	COG2755	lipolytic protein G-D-S-L family
EBA21_RS13635	COG0657	acetylesterase activity
EBA21_RS13660	COG0488	(ABC) transporter
EBA21_RS13685	COG4651	solute:proton antiporter activity
EBA21_RS13685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EBA21_RS13700	COG4772	TonB-dependent receptor
EBA21_RS13710	COG4264	IucA IucC family
EBA21_RS13725	COG0019	diaminopimelate decarboxylase activity
EBA21_RS13785	COG4206	TonB-dependent receptor
EBA21_RS13825	COG0542	response to heat
EBA21_RS13855	COG3039	Transposase
EBA21_RS13875	COG0534	Mate efflux family protein
EBA21_RS13890	COG0336	Belongs to the RNA methyltransferase TrmD family
EBA21_RS13895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EBA21_RS13900	COG0228	four-way junction DNA binding
EBA21_RS13925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EBA21_RS13940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EBA21_RS13985	COG1555	photosystem II stabilization
EBA21_RS13990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBA21_RS14005	COG3178	'Phosphotransferase
EBA21_RS14010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EBA21_RS14020	COG0628	permease
EBA21_RS14030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EBA21_RS14045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EBA21_RS14065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EBA21_RS14070	COG0271	Belongs to the BolA IbaG family
EBA21_RS14080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EBA21_RS14090	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EBA21_RS14095	COG1137	ATPase activity
EBA21_RS14110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBA21_RS14115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EBA21_RS14120	COG1660	Displays ATPase and GTPase activities
EBA21_RS14130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBA21_RS14135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBA21_RS14145	COG2239	Acts as a magnesium transporter
EBA21_RS14155	COG1294	oxidase, subunit
EBA21_RS14160	COG1271	oxidase subunit
EBA21_RS14185	COG1113	amino acid transport
EBA21_RS14200	COG2197	response regulator
EBA21_RS14205	COG0531	amino acid
EBA21_RS14285	COG0754	glutathionylspermidine amidase activity
EBA21_RS14310	COG1842	Phage shock protein A
EBA21_RS14325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EBA21_RS14330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EBA21_RS14340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EBA21_RS14435	COG0583	DNA-binding transcription factor activity
EBA21_RS14445	COG3039	Transposase
EBA21_RS14530	COG1278	Cold shock
EBA21_RS14580	COG3039	Transposase
EBA21_RS14595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBA21_RS14610	COG0557	exoribonuclease II activity
EBA21_RS14640	COG1960	acyl-CoA dehydrogenase activity
EBA21_RS14645	COG2226	methyltransferase
EBA21_RS14650	COG0646	methionine synthase
EBA21_RS14650	COG1410	methionine synthase
EBA21_RS14655	COG1410	methionine synthase
EBA21_RS14655	COG0646	methionine synthase
EBA21_RS14665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA21_RS14675	COG1609	Transcriptional regulator
EBA21_RS14690	COG2900	Belongs to the SlyX family
EBA21_RS14705	COG0386	Belongs to the glutathione peroxidase family
EBA21_RS14715	COG1725	Transcriptional regulator
EBA21_RS14720	COG1131	(ABC) transporter
EBA21_RS14800	COG2850	peptidyl-arginine hydroxylation
EBA21_RS14835	COG1132	(ABC) transporter
EBA21_RS14850	COG0583	DNA-binding transcription factor activity
EBA21_RS14865	COG0287	Prephenate dehydrogenase
EBA21_RS14865	COG1605	Chorismate mutase
EBA21_RS14870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EBA21_RS14880	COG0484	heat shock protein binding
EBA21_RS14890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EBA21_RS14900	COG0497	DNA recombination
EBA21_RS14910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA21_RS14920	COG2914	Belongs to the UPF0125 (RnfH) family
EBA21_RS14930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EBA21_RS14945	COG1960	acyl-CoA dehydrogenase activity
EBA21_RS14955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EBA21_RS15000	COG2814	Major facilitator Superfamily
EBA21_RS15005	COG1566	PFAM secretion protein HlyD family protein
EBA21_RS15020	COG2207	Transcriptional regulator
EBA21_RS15050	COG4774	siderophore transport
EBA21_RS15060	COG0367	asparagine synthase
EBA21_RS15065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBA21_RS15075	COG1393	Belongs to the ArsC family
EBA21_RS15135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EBA21_RS15150	COG0233	cytoplasmic translational termination
EBA21_RS15160	COG0575	Belongs to the CDS family
EBA21_RS15170	COG0750	zinc metalloprotease
EBA21_RS15195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBA21_RS15200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBA21_RS15220	COG0825	malonyl-CoA metabolic process
EBA21_RS15230	COG4771	TonB-dependent receptor
EBA21_RS15260	COG1981	membrane
EBA21_RS15305	COG0529	Catalyzes the synthesis of activated sulfate
EBA21_RS15305	COG2895	sulfate adenylyltransferase (ATP) activity
EBA21_RS15345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EBA21_RS15365	COG2040	homocysteine
EBA21_RS15370	COG0833	amino acid
EBA21_RS15390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBA21_RS15390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBA21_RS15400	COG2878	Part of a membrane complex involved in electron transport
EBA21_RS15420	COG1595	DNA-templated transcription, initiation
EBA21_RS15445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EBA21_RS15460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EBA21_RS15465	COG0251	oxidation-reduction process
EBA21_RS15475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EBA21_RS15475	COG0392	lysyltransferase activity
EBA21_RS15520	COG2814	Major facilitator Superfamily
EBA21_RS15525	COG1902	pentaerythritol trinitrate reductase activity
EBA21_RS15540	COG2824	Alkylphosphonate utilization operon protein PhnA
EBA21_RS15555	COG1047	Peptidyl-prolyl cis-trans
EBA21_RS15610	COG3039	Transposase
EBA21_RS15615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EBA21_RS15620	COG3039	Transposase
EBA21_RS15635	COG1451	nucleotide metabolic process
EBA21_RS15660	COG0183	Belongs to the thiolase family
EBA21_RS15690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EBA21_RS15690	COG1793	dna ligase
EBA21_RS15700	COG1793	dna ligase
EBA21_RS15705	COG1201	RNA secondary structure unwinding
EBA21_RS15725	COG1278	Cold shock
EBA21_RS15730	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EBA21_RS15735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EBA21_RS15745	COG3046	protein related to deoxyribodipyrimidine photolyase
EBA21_RS15750	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
EBA21_RS15755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EBA21_RS15780	COG2954	triphosphatase activity
EBA21_RS15795	COG1381	Involved in DNA repair and RecF pathway recombination
EBA21_RS15825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBA21_RS15840	COG1024	Enoyl-CoA hydratase
EBA21_RS15840	COG1250	3-hydroxyacyl-CoA dehydrogenase
EBA21_RS15860	COG1024	Enoyl-CoA hydratase
EBA21_RS15865	COG1960	acyl-CoA dehydrogenase activity
EBA21_RS15935	COG2353	YceI-like domain
EBA21_RS15945	COG2353	YceI-like domain
EBA21_RS15960	COG1760	l-serine dehydratase
EBA21_RS15970	COG0626	cystathionine gamma-synthase activity
EBA21_RS15975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EBA21_RS15980	COG0739	heme binding
EBA21_RS15985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EBA21_RS15990	COG1272	protein, Hemolysin III
EBA21_RS16010	COG0463	Glycosyl transferase, family 2
EBA21_RS16020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EBA21_RS16030	COG4771	TonB-dependent receptor
EBA21_RS16035	COG1309	transcriptional regulator
EBA21_RS16045	COG1960	acyl-CoA dehydrogenase activity
EBA21_RS16080	COG0509	glycine decarboxylation via glycine cleavage system
EBA21_RS16095	COG0330	HflC and HflK could
EBA21_RS16110	COG3956	TIGRFAM MazG family protein
EBA21_RS16120	COG0494	nUDIX hydrolase
EBA21_RS16130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EBA21_RS16135	COG0837	glucose binding
EBA21_RS16150	COG3858	chitin binding
EBA21_RS16150	COG1388	LysM domain
EBA21_RS16170	COG1472	Belongs to the glycosyl hydrolase 3 family
EBA21_RS16235	COG3537	Alpha-1,2-mannosidase
EBA21_RS16285	COG1446	asparaginase
EBA21_RS16335	COG0643	Histidine kinase
EBA21_RS16335	COG0784	Response regulator, receiver
EBA21_RS16335	COG2198	Histidine kinase
EBA21_RS16340	COG0840	transmembrane signaling receptor activity
EBA21_RS16345	COG0835	chemotaxis
EBA21_RS16360	COG0189	ligase activity
EBA21_RS16370	COG1397	ADP-ribosylglycohydrolase
EBA21_RS16380	COG1199	ATP-dependent helicase activity
EBA21_RS16390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EBA21_RS16395	COG1215	transferase activity, transferring glycosyl groups
EBA21_RS16405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EBA21_RS16420	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EBA21_RS16425	COG0535	radical SAM domain protein
EBA21_RS16430	COG0535	radical SAM domain protein
EBA21_RS16465	COG1643	Atp-dependent helicase
EBA21_RS16470	COG0783	Belongs to the Dps family
EBA21_RS16480	COG0514	ATP-dependent DNA helicase (RecQ)
EBA21_RS16505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EBA21_RS16530	COG0602	queuosine metabolic process
EBA21_RS16540	COG2885	chlorophyll binding
EBA21_RS16545	COG0823	Involved in the tonB-independent uptake of proteins
EBA21_RS16555	COG0848	biopolymer transport protein
EBA21_RS16565	COG0824	Thioesterase
EBA21_RS16570	COG2255	four-way junction helicase activity
EBA21_RS16580	COG0632	four-way junction helicase activity
EBA21_RS16780	COG2022	thiamine diphosphate biosynthetic process
EBA21_RS16795	COG3273	potassium ion transport
EBA21_RS16795	COG0471	metal ion transport
EBA21_RS16825	COG1970	mechanosensitive ion channel activity
EBA21_RS16850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBA21_RS16880	COG0308	aminopeptidase N
EBA21_RS16885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBA21_RS16900	COG2895	sulfate adenylyltransferase (ATP) activity
EBA21_RS16900	COG0529	Catalyzes the synthesis of activated sulfate
EBA21_RS16905	COG0175	sulfate reduction
EBA21_RS16910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EBA21_RS16915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EBA21_RS16920	COG0175	sulfate reduction
EBA21_RS16945	COG2205	protein histidine kinase activity
EBA21_RS16945	COG2198	Histidine kinase
EBA21_RS16945	COG0784	Response regulator, receiver
EBA21_RS16995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EBA21_RS17000	COG3588	fructose-bisphosphate aldolase
EBA21_RS17005	COG0469	pyruvate kinase activity
EBA21_RS17015	COG0126	phosphoglycerate kinase activity
EBA21_RS17050	COG0753	catalase activity
EBA21_RS17080	COG1917	Cupin 2, conserved barrel domain protein
EBA21_RS17080	COG2207	Transcriptional regulator
EBA21_RS17100	COG1506	peptidase
EBA21_RS17100	COG0823	Involved in the tonB-independent uptake of proteins
EBA21_RS17125	COG1297	OPT oligopeptide transporter protein
EBA21_RS17145	COG0587	DNA-directed DNA polymerase activity
EBA21_RS17225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EBA21_RS17240	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EBA21_RS17245	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EBA21_RS17250	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EBA21_RS17270	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EBA21_RS17440	COG3179	chitinase
EBA21_RS17480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBA21_RS17490	COG0412	Dienelactone hydrolase
EBA21_RS17510	COG0717	Belongs to the dCTP deaminase family
EBA21_RS17515	COG0489	protein tyrosine kinase activity
EBA21_RS17560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBA21_RS17565	COG2311	Membrane
EBA21_RS17570	COG1047	Peptidyl-prolyl cis-trans
EBA21_RS17575	COG0791	NLP P60 protein
EBA21_RS17580	COG0791	NLP P60 protein
EBA21_RS17600	COG1301	dicarboxylic acid transport
EBA21_RS17605	COG1785	Belongs to the alkaline phosphatase family
EBA21_RS17610	COG0037	tRNA processing
EBA21_RS17615	COG1722	exodeoxyribonuclease VII activity
EBA21_RS17620	COG0142	geranyltranstransferase activity
EBA21_RS17645	COG0312	modulator of DNA gyrase
EBA21_RS17650	COG3028	Belongs to the UPF0307 family
EBA21_RS17655	COG0312	modulator of DNA gyrase
EBA21_RS17665	COG3164	Protein of unknown function
EBA21_RS17680	COG2968	Membrane
EBA21_RS17710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EBA21_RS17735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EBA21_RS17765	COG3118	belongs to the thioredoxin family
EBA21_RS17830	COG3039	Transposase
EBA21_RS17855	COG3039	Transposase
EBA21_RS17885	COG3209	COG3209 Rhs family protein
EBA21_RS17890	COG3039	Transposase
EBA21_RS17915	COG3209	COG3209 Rhs family protein
EBA21_RS17930	COG3039	Transposase
EBA21_RS17965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EBA21_RS17970	COG1845	cytochrome c oxidase, subunit III
EBA21_RS17975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EBA21_RS17990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EBA21_RS17995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EBA21_RS18005	COG0196	riboflavin kinase activity
EBA21_RS18010	COG0728	peptidoglycan biosynthetic process
EBA21_RS18015	COG0268	Binds directly to 16S ribosomal RNA
EBA21_RS18020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EBA21_RS18025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EBA21_RS18035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EBA21_RS18040	COG0824	Thioesterase
EBA21_RS18055	COG1946	Acyl-CoA thioesterase
EBA21_RS18065	COG1595	DNA-templated transcription, initiation
EBA21_RS18080	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EBA21_RS18120	COG1877	trehalose-phosphatase activity
EBA21_RS18125	COG3387	PFAM Glycoside hydrolase 15-related
EBA21_RS18150	COG0564	pseudouridine synthase activity
EBA21_RS18155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA21_RS18160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBA21_RS18160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EBA21_RS18170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EBA21_RS18175	COG0045	succinate-CoA ligase (ADP-forming) activity
EBA21_RS18215	COG2194	sulfuric ester hydrolase activity
EBA21_RS18220	COG4969	Belongs to the N-Me-Phe pilin family
EBA21_RS18230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EBA21_RS18265	COG3039	Transposase
EBA21_RS18280	COG3209	COG3209 Rhs family protein
EBA21_RS18300	COG3039	Transposase
EBA21_RS18350	COG1132	(ABC) transporter
EBA21_RS18380	COG0745	RESPONSE REGULATOR receiver
EBA21_RS18385	COG5002	protein histidine kinase activity
EBA21_RS18385	COG5000	phosphorelay sensor kinase activity
EBA21_RS18390	COG0475	glutathione-regulated potassium exporter activity
EBA21_RS18400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBA21_RS18425	COG1187	pseudouridine synthase activity
EBA21_RS18430	COG5002	protein histidine kinase activity
EBA21_RS18430	COG5001	Diguanylate cyclase
EBA21_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS18565	COG0415	Belongs to the DNA photolyase family
EBA21_RS18570	COG0305	Participates in initiation and elongation during chromosome replication
EBA21_RS18580	COG0367	asparagine synthase
EBA21_RS18595	COG1960	acyl-CoA dehydrogenase activity
EBA21_RS18610	COG0084	hydrolase, TatD family'
EBA21_RS18615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EBA21_RS18675	COG0735	belongs to the Fur family
EBA21_RS18680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBA21_RS18730	COG3039	Transposase
EBA21_RS18780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EBA21_RS18790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EBA21_RS18805	COG0643	Histidine kinase
EBA21_RS18805	COG2198	Histidine kinase
EBA21_RS18815	COG0840	transmembrane signaling receptor activity
EBA21_RS18820	COG0835	chemotaxis
EBA21_RS18825	COG2202	Pas domain
EBA21_RS18825	COG2199	diguanylate cyclase activity
EBA21_RS18825	COG2200	EAL domain
EBA21_RS18830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EBA21_RS18870	COG0588	phosphoglycerate mutase activity
EBA21_RS18875	COG1515	deoxyribonuclease V activity
EBA21_RS18885	COG1741	Belongs to the pirin family
EBA21_RS18955	COG3039	Transposase
EBA21_RS19090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EBA21_RS19105	COG2197	response regulator
EBA21_RS19110	COG4585	Histidine kinase
EBA21_RS19130	COG2894	cell division
EBA21_RS19135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EBA21_RS19145	COG0642	Histidine kinase
EBA21_RS19150	COG0745	RESPONSE REGULATOR receiver
EBA21_RS19155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EBA21_RS19165	COG2194	sulfuric ester hydrolase activity
EBA21_RS19195	COG3551	Protein conserved in bacteria
EBA21_RS19260	COG0203	ribosomal protein L17
EBA21_RS19270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EBA21_RS19275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EBA21_RS19285	COG0201	protein transport
EBA21_RS19295	COG1841	ribosomal large subunit assembly
EBA21_RS19305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EBA21_RS19325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EBA21_RS19330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EBA21_RS19335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EBA21_RS19340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EBA21_RS19345	COG0255	Belongs to the universal ribosomal protein uL29 family
EBA21_RS19350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EBA21_RS19360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EBA21_RS19375	COG0089	rRNA binding
EBA21_RS19380	COG0088	Forms part of the polypeptide exit tunnel
EBA21_RS19385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EBA21_RS19390	COG0051	transcription antitermination factor activity, RNA binding
EBA21_RS19410	COG0049	tRNA binding
EBA21_RS19415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EBA21_RS19420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EBA21_RS19425	COG0085	RNA polymerase activity
EBA21_RS19430	COG0222	ribosome binding
EBA21_RS19435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EBA21_RS19445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EBA21_RS19455	COG0250	Participates in transcription elongation, termination and antitermination
EBA21_RS19460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EBA21_RS19490	COG0012	GTP binding
EBA21_RS19495	COG0193	aminoacyl-tRNA hydrolase activity
EBA21_RS19505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EBA21_RS19520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EBA21_RS19530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EBA21_RS19535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EBA21_RS19545	COG0521	Mo-molybdopterin cofactor biosynthetic process
EBA21_RS19565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBA21_RS19570	COG1295	ribonuclease BN
EBA21_RS19600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EBA21_RS19605	COG1404	Belongs to the peptidase S8 family
EBA21_RS19620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EBA21_RS19650	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EBA21_RS19675	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EBA21_RS19690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EBA21_RS19690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EBA21_RS19730	COG2890	protein-(glutamine-N5) methyltransferase activity
EBA21_RS19740	COG3634	alkyl hydroperoxide reductase activity
EBA21_RS19745	COG0583	DNA-binding transcription factor activity
EBA21_RS19755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBA21_RS19760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EBA21_RS19810	COG2197	response regulator
EBA21_RS19930	COG3386	PFAM SMP-30 Gluconolaconase
EBA21_RS19950	COG1024	Enoyl-CoA hydratase
EBA21_RS19960	COG0318	PFAM AMP-dependent synthetase and ligase
EBA21_RS19965	COG0583	DNA-binding transcription factor activity
EBA21_RS20005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EBA21_RS20010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EBA21_RS20020	COG2096	Adenosyltransferase
EBA21_RS20025	COG0123	including yeast histone deacetylase and acetoin utilization protein
EBA21_RS20040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EBA21_RS20050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EBA21_RS20055	COG2967	ApaG domain
EBA21_RS20060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EBA21_RS20080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EBA21_RS20100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EBA21_RS20120	COG0642	Histidine kinase
EBA21_RS20135	COG4181	ATPase activity
EBA21_RS20145	COG2175	clavaminate synthase activity
EBA21_RS20195	COG0667	Aldo Keto reductase
EBA21_RS20205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EBA21_RS20210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA21_RS20225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EBA21_RS20240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EBA21_RS20280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EBA21_RS20285	COG2226	methyltransferase
EBA21_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS20340	COG0604	alcohol dehydrogenase
EBA21_RS20340	COG3321	synthase
EBA21_RS20355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EBA21_RS20370	COG0494	nUDIX hydrolase
EBA21_RS20380	COG0653	protein targeting
EBA21_RS20385	COG4942	peptidase
EBA21_RS20385	COG1388	LysM domain
EBA21_RS20395	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EBA21_RS20410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EBA21_RS20415	COG1181	Belongs to the D-alanine--D-alanine ligase family
EBA21_RS20420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBA21_RS20435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBA21_RS20440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EBA21_RS20455	COG3116	cell division
EBA21_RS20460	COG0275	rRNA processing
EBA21_RS20495	COG0792	nuclease activity
EBA21_RS20500	COG1988	membrane-bound metal-dependent
EBA21_RS20505	COG0277	FAD linked oxidase domain protein
EBA21_RS20510	COG0745	RESPONSE REGULATOR receiver
EBA21_RS20515	COG2205	protein histidine kinase activity
EBA21_RS20525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EBA21_RS20530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EBA21_RS20555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EBA21_RS20560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EBA21_RS20565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EBA21_RS20585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBA21_RS20585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBA21_RS20605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EBA21_RS20625	COG0488	(ABC) transporter
EBA21_RS20680	COG2205	protein histidine kinase activity
EBA21_RS20715	COG2205	protein histidine kinase activity
EBA21_RS20730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EBA21_RS20775	COG3039	Transposase
EBA21_RS20780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EBA21_RS20890	COG1649	PFAM Uncharacterised BCR, COG1649
EBA21_RS20890	COG0726	polysaccharide deacetylase
EBA21_RS20895	COG1215	transferase activity, transferring glycosyl groups
EBA21_RS20905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EBA21_RS20910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBA21_RS20915	COG1609	Transcriptional regulator
EBA21_RS20925	COG2188	Transcriptional regulator
EBA21_RS20945	COG3250	beta-galactosidase activity
EBA21_RS20995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EBA21_RS21000	COG4191	Histidine kinase
EBA21_RS21005	COG0784	Response regulator, receiver
EBA21_RS21010	COG4251	negative regulation of phosphorylation
EBA21_RS21015	COG2823	Periplasmic or secreted lipoprotein
EBA21_RS21020	COG0673	inositol 2-dehydrogenase activity
EBA21_RS21025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EBA21_RS21060	COG1056	cytidyltransferase-related domain
EBA21_RS21060	COG1051	belongs to the nudix hydrolase family
EBA21_RS21085	COG2921	Belongs to the UPF0250 family
EBA21_RS21095	COG1686	Belongs to the peptidase S11 family
EBA21_RS21100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EBA21_RS21105	COG2951	lytic endotransglycosylase activity
EBA21_RS21150	COG3039	Transposase
EBA21_RS21180	COG0772	Belongs to the SEDS family
EBA21_RS21195	COG1792	Involved in formation and maintenance of cell shape
EBA21_RS21200	COG1077	Cell shape determining protein MreB Mrl
EBA21_RS21205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBA21_RS21255	COG2199	diguanylate cyclase activity
EBA21_RS21260	COG0308	aminopeptidase N
EBA21_RS21290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EBA21_RS21320	COG0436	Aminotransferase
EBA21_RS21335	COG1505	serine-type exopeptidase activity
EBA21_RS21360	COG0181	hydroxymethylbilane synthase activity
EBA21_RS21370	COG3275	phosphorelay sensor kinase activity
EBA21_RS21425	COG0659	secondary active sulfate transmembrane transporter activity
EBA21_RS21430	COG5297	Belongs to the glycosyl hydrolase family 6
EBA21_RS21430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA21_RS21435	COG0840	transmembrane signaling receptor activity
EBA21_RS21495	COG3039	Transposase
EBA21_RS21515	COG0598	Magnesium transport protein CorA
EBA21_RS21525	COG1113	amino acid transport
EBA21_RS21535	COG5297	Belongs to the glycosyl hydrolase family 6
EBA21_RS21540	COG4305	rare lipoprotein A
EBA21_RS21545	COG0697	spore germination
EBA21_RS21605	COG4221	oxidoreductase activity
EBA21_RS21635	COG0456	acetyltransferase
EBA21_RS21645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EBA21_RS21700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EBA21_RS21700	COG2111	Na H antiporter
EBA21_RS21705	COG1006	Multisubunit Na H antiporter MnhC subunit
EBA21_RS21710	COG0651	ATP synthesis coupled electron transport
EBA21_RS21720	COG2212	antiporter activity
EBA21_RS21725	COG1320	monovalent cation:proton antiporter activity
EBA21_RS21740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EBA21_RS21760	COG3104	oligopeptide transport
EBA21_RS21765	COG3483	tryptophan 2,3-dioxygenase activity
EBA21_RS21775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EBA21_RS21810	COG0183	Belongs to the thiolase family
EBA21_RS21855	COG3039	Transposase
EBA21_RS21935	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EBA21_RS21940	COG3023	N-Acetylmuramoyl-L-alanine amidase
EBA21_RS21950	COG4948	Mandelate Racemase Muconate Lactonizing
EBA21_RS21980	COG0531	amino acid
EBA21_RS22005	COG4682	membrane
EBA21_RS22010	COG2133	pyrroloquinoline quinone binding
EBA21_RS22070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EBA21_RS22075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EBA21_RS22085	COG1610	YqeY-like protein
EBA21_RS22105	COG1295	ribonuclease BN
EBA21_RS22110	COG0358	DNA primase activity
EBA21_RS22165	COG3039	Transposase
EBA21_RS22220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EBA21_RS22230	COG1560	Kdo2-lipid A biosynthetic process
EBA21_RS22280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EBA21_RS22280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EBA21_RS22285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EBA21_RS22290	COG0242	peptide deformylase activity
EBA21_RS22295	COG1652	LysM domain
EBA21_RS22300	COG0758	DNA mediated transformation
EBA21_RS22305	COG2922	Belongs to the Smg family
EBA21_RS22320	COG1754	DNA topoisomerase type I activity
EBA21_RS22320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EBA21_RS22325	COG0009	L-threonylcarbamoyladenylate synthase
EBA21_RS22340	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS22350	COG0616	signal peptide processing
EBA21_RS22355	COG0534	Mate efflux family protein
EBA21_RS22380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EBA21_RS22420	COG1324	tolerance protein
EBA21_RS22440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EBA21_RS22445	COG0511	ligase activity, forming carbon-carbon bonds
EBA21_RS22455	COG0439	Biotin carboxylase
EBA21_RS22515	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EBA21_RS22565	COG3210	domain, Protein
EBA21_RS22620	COG2831	hemolysin activation secretion protein
EBA21_RS22650	COG2267	carboxylic ester hydrolase activity
EBA21_RS22660	COG2267	carboxylic ester hydrolase activity
EBA21_RS22675	COG0419	ATPase involved in DNA repair
EBA21_RS22685	COG0151	Belongs to the GarS family
EBA21_RS22705	COG1289	transmembrane transporter activity
EBA21_RS22720	COG2814	Major facilitator Superfamily
EBA21_RS22745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EBA21_RS22780	COG0745	RESPONSE REGULATOR receiver
EBA21_RS22830	COG0739	heme binding
EBA21_RS22845	COG2211	Major facilitator Superfamily
EBA21_RS22850	COG0708	Exodeoxyribonuclease III
EBA21_RS22865	COG1192	Involved in chromosome partitioning
EBA21_RS22870	COG1475	DNA binding
EBA21_RS22885	COG0463	Glycosyl transferase, family 2
EBA21_RS22910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EBA21_RS22935	COG4221	oxidoreductase activity
EBA21_RS22960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EBA21_RS22965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EBA21_RS22980	COG3485	protocatechuate 3,4-dioxygenase
EBA21_RS22985	COG3485	protocatechuate 3,4-dioxygenase
EBA21_RS23025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EBA21_RS23035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EBA21_RS23050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EBA21_RS23050	COG1042	CoA-binding domain protein
EBA21_RS23050	COG0045	succinate-CoA ligase (ADP-forming) activity
EBA21_RS23060	COG2239	Acts as a magnesium transporter
EBA21_RS23075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EBA21_RS23095	COG3100	YcgL domain-containing protein
EBA21_RS23100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EBA21_RS23110	COG0463	Glycosyl transferase, family 2
EBA21_RS23125	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS23140	COG0156	8-amino-7-oxononanoate synthase activity
EBA21_RS23145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EBA21_RS23150	COG1040	competence protein
EBA21_RS23155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EBA21_RS23170	COG0628	permease
EBA21_RS23180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EBA21_RS23190	COG1595	DNA-templated transcription, initiation
EBA21_RS23195	COG0753	catalase activity
EBA21_RS23250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBA21_RS23255	COG0180	Tryptophanyl-tRNA synthetase
EBA21_RS23260	COG3237	CsbD-like
EBA21_RS23300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EBA21_RS23315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EBA21_RS23320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EBA21_RS23320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EBA21_RS23360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EBA21_RS23390	COG1566	PFAM secretion protein HlyD family protein
EBA21_RS23410	COG1199	ATP-dependent helicase activity
EBA21_RS23445	COG0583	DNA-binding transcription factor activity
EBA21_RS23495	COG0625	glutathione transferase activity
EBA21_RS23530	COG4555	ABC transporter
EBA21_RS23540	COG1476	TRANSCRIPTIONal
EBA21_RS23565	COG1131	(ABC) transporter
EBA21_RS23570	COG0842	Transport permease protein
EBA21_RS23690	COG1181	Belongs to the D-alanine--D-alanine ligase family
EBA21_RS23705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EBA21_RS23715	COG0564	pseudouridine synthase activity
EBA21_RS23745	COG0339	signal peptide processing
EBA21_RS23775	COG3254	rhamnose metabolic process
EBA21_RS23780	COG0738	Major facilitator superfamily
EBA21_RS23785	COG1414	Transcriptional regulator
EBA21_RS23800	COG2205	protein histidine kinase activity
EBA21_RS23810	COG3459	Glycosyltransferase 36 associated
EBA21_RS23815	COG2211	Major facilitator Superfamily
EBA21_RS23820	COG3265	gluconokinase activity
EBA21_RS23830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBA21_RS23870	COG3039	Transposase
EBA21_RS23935	COG1127	ABC transporter
EBA21_RS23940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EBA21_RS23945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EBA21_RS23960	COG2853	Lipoprotein
EBA21_RS23990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EBA21_RS24060	COG0676	glucose-6-phosphate 1-epimerase activity
EBA21_RS24085	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA21_RS24095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA21_RS24105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EBA21_RS24115	COG1064	alcohol dehydrogenase
EBA21_RS24165	COG1522	sequence-specific DNA binding
EBA21_RS24170	COG3186	Phenylalanine-4-hydroxylase
EBA21_RS24185	COG2755	lipolytic protein G-D-S-L family
EBA21_RS24210	COG0656	L-ascorbic acid biosynthetic process
EBA21_RS24215	COG2130	NADP-dependent
EBA21_RS24220	COG0667	Aldo Keto reductase
EBA21_RS24230	COG1187	pseudouridine synthase activity
EBA21_RS24245	COG1643	Atp-dependent helicase
EBA21_RS24250	COG4807	Protein conserved in bacteria
EBA21_RS24255	COG4948	Mandelate Racemase Muconate Lactonizing
EBA21_RS24265	COG0179	Fumarylacetoacetate (FAA) hydrolase
EBA21_RS24270	COG1028	Short-chain dehydrogenase reductase Sdr
EBA21_RS24330	COG3162	membrane
EBA21_RS24335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EBA21_RS24350	COG0708	Exodeoxyribonuclease III
EBA21_RS24365	COG2091	lysine biosynthetic process via aminoadipic acid
EBA21_RS24375	COG3540	Alkaline phosphatase
EBA21_RS24380	COG0357	Ribosomal RNA small subunit methyltransferase G
EBA21_RS24405	COG2159	amidohydrolase
EBA21_RS24420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBA21_RS24425	COG0583	DNA-binding transcription factor activity
EBA21_RS24430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA21_RS24450	COG0210	DNA helicase
EBA21_RS24465	COG0531	amino acid
EBA21_RS24480	COG1322	Protein conserved in bacteria
EBA21_RS24495	COG0386	Belongs to the glutathione peroxidase family
EBA21_RS24550	COG0793	Belongs to the peptidase S41A family
EBA21_RS24555	COG4942	peptidase
EBA21_RS24565	COG2234	aminopeptidase activity
EBA21_RS24610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBA21_RS24615	COG0302	gtp cyclohydrolase
EBA21_RS24645	COG0477	Major facilitator Superfamily
EBA21_RS24655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBA21_RS24785	COG1929	Belongs to the glycerate kinase type-1 family
EBA21_RS24790	COG2271	Major facilitator Superfamily
EBA21_RS24805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBA21_RS24815	COG0861	Integral membrane protein TerC family
EBA21_RS24825	COG0584	glycerophosphoryl diester phosphodiesterase
EBA21_RS24835	COG0671	phosphoesterase, PA-phosphatase related
EBA21_RS24840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EBA21_RS24850	COG0726	polysaccharide deacetylase
EBA21_RS24855	COG0706	membrane insertase activity