locus-tag	class	description
BRN52_RS00025	COG0187	DNA topoisomerase II activity
BRN52_RS00035	COG0501	Belongs to the peptidase M48B family
BRN52_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BRN52_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN52_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRN52_RS00095	COG4772	TonB-dependent receptor
BRN52_RS00110	COG3039	Transposase
BRN52_RS00115	COG1304	FMN binding
BRN52_RS00120	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRN52_RS00135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BRN52_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN52_RS00250	COG2826	transposase and inactivated derivatives, IS30 family
BRN52_RS00275	COG3039	Transposase
BRN52_RS00285	COG1090	epimerase
BRN52_RS00295	COG0642	Histidine kinase
BRN52_RS00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN52_RS00415	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN52_RS00500	COG3264	Mechanosensitive ion channel
BRN52_RS00500	COG1511	domain protein
BRN52_RS00515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRN52_RS00525	COG2354	Protein conserved in bacteria
BRN52_RS00530	COG1649	PFAM Uncharacterised BCR, COG1649
BRN52_RS00550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRN52_RS00575	COG0702	epimerase
BRN52_RS00585	COG1858	cytochrome C peroxidase
BRN52_RS00670	COG0513	Belongs to the DEAD box helicase family
BRN52_RS00680	COG3039	Transposase
BRN52_RS00730	COG1136	(ABC) transporter
BRN52_RS00765	COG1136	(ABC) transporter
BRN52_RS00810	COG1272	protein, Hemolysin III
BRN52_RS00815	COG1205	dead DEAH box helicase
BRN52_RS00815	COG1111	helicase
BRN52_RS00875	COG0070	glutamate synthase
BRN52_RS00875	COG0069	glutamate synthase activity
BRN52_RS00875	COG0067	glutamate synthase
BRN52_RS00880	COG0493	'glutamate synthase
BRN52_RS00925	COG1609	Transcriptional regulator
BRN52_RS00960	COG0366	Alpha amylase catalytic
BRN52_RS00965	COG0366	Alpha amylase catalytic
BRN52_RS01030	COG0606	chelatase, subunit chli
BRN52_RS01080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRN52_RS01085	COG1166	arginine decarboxylase activity
BRN52_RS01135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRN52_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS01185	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRN52_RS01200	COG0210	DNA helicase
BRN52_RS01215	COG3132	Protein of unknown function, DUF480
BRN52_RS01220	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRN52_RS01225	COG0284	orotidine-5'-phosphate decarboxylase activity
BRN52_RS01260	COG2937	Belongs to the GPAT DAPAT family
BRN52_RS01265	COG3321	synthase
BRN52_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS01265	COG0604	alcohol dehydrogenase
BRN52_RS01285	COG3328	transposase activity
BRN52_RS01335	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRN52_RS01345	COG1119	ATPase activity
BRN52_RS01360	COG0517	IMP dehydrogenase activity
BRN52_RS01360	COG1125	glycine betaine transport
BRN52_RS01375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_RS01380	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRN52_RS01385	COG3550	peptidyl-serine autophosphorylation
BRN52_RS01390	COG1396	sequence-specific DNA binding
BRN52_RS01410	COG0489	protein tyrosine kinase activity
BRN52_RS01415	COG2062	phosphohistidine phosphatase, SixA
BRN52_RS01425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN52_RS01470	COG1968	undecaprenyl-diphosphatase activity
BRN52_RS01475	COG0174	glutamine synthetase
BRN52_RS01480	COG0347	Belongs to the P(II) protein family
BRN52_RS01485	COG0004	ammonium transporteR
BRN52_RS01490	COG3852	Histidine kinase
BRN52_RS01495	COG2204	response regulator
BRN52_RS01500	COG2032	superoxide dismutase activity
BRN52_RS01505	COG2032	superoxide dismutase activity
BRN52_RS01555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRN52_RS01560	COG1074	ATP-dependent DNA helicase activity
BRN52_RS01570	COG3549	Plasmid maintenance system killer
BRN52_RS01660	COG1764	response to oxidative stress
BRN52_RS01665	COG1846	Transcriptional regulator
BRN52_RS01715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRN52_RS01755	COG2211	Major facilitator Superfamily
BRN52_RS01780	COG3693	PFAM glycoside hydrolase, family 10
BRN52_RS01805	COG0246	Mannitol dehydrogenase
BRN52_RS01810	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN52_RS01820	COG4948	Mandelate Racemase Muconate Lactonizing
BRN52_RS01830	COG3661	Belongs to the glycosyl hydrolase 67 family
BRN52_RS01850	COG0037	tRNA processing
BRN52_RS01855	COG2974	May be involved in recombination
BRN52_RS01885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRN52_RS01895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRN52_RS01905	COG0805	protein transport
BRN52_RS01915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRN52_RS01915	COG0519	Catalyzes the synthesis of GMP from XMP
BRN52_RS01940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN52_RS01945	COG0752	glycyl-tRNA synthetase alpha subunit
BRN52_RS01955	COG0457	Tetratricopeptide repeat
BRN52_RS01960	COG4771	TonB-dependent receptor
BRN52_RS01975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRN52_RS01985	COG0697	spore germination
BRN52_RS01995	COG0523	cobalamin synthesis protein
BRN52_RS02050	COG1960	acyl-CoA dehydrogenase activity
BRN52_RS02055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRN52_RS02060	COG4770	biotin carboxylase activity
BRN52_RS02120	COG2072	flavoprotein involved in K transport
BRN52_RS02140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRN52_RS02185	COG0084	hydrolase, TatD family'
BRN52_RS02205	COG0583	DNA-binding transcription factor activity
BRN52_RS02210	COG2814	Major facilitator Superfamily
BRN52_RS02220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRN52_RS02225	COG1902	pentaerythritol trinitrate reductase activity
BRN52_RS02255	COG0745	RESPONSE REGULATOR receiver
BRN52_RS02275	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN52_RS02280	COG0583	DNA-binding transcription factor activity
BRN52_RS02315	COG0702	epimerase
BRN52_RS02320	COG1733	regulation of RNA biosynthetic process
BRN52_RS02390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRN52_RS02405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRN52_RS02440	COG2911	Protein conserved in bacteria
BRN52_RS02445	COG0729	surface antigen
BRN52_RS02460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRN52_RS02465	COG3118	belongs to the thioredoxin family
BRN52_RS02475	COG2884	Cell division ATP-binding protein ftsE
BRN52_RS02480	COG2177	Part of the ABC transporter FtsEX involved in
BRN52_RS02485	COG3437	response regulator, receiver
BRN52_RS02490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRN52_RS02495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN52_RS02505	COG1252	NADH dehydrogenase
BRN52_RS02530	COG0459	protein refolding
BRN52_RS02540	COG4771	TonB-dependent receptor
BRN52_RS02555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRN52_RS02595	COG3386	PFAM SMP-30 Gluconolaconase
BRN52_RS02610	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN52_RS02640	COG2353	YceI-like domain
BRN52_RS02705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BRN52_RS02755	COG0408	coproporphyrinogen oxidase activity
BRN52_RS02765	COG3039	Transposase
BRN52_RS02790	COG0129	dihydroxy-acid dehydratase activity
BRN52_RS02800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRN52_RS02840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRN52_RS02845	COG0318	PFAM AMP-dependent synthetase and ligase
BRN52_RS02850	COG0727	PFAM Uncharacterised protein family (UPF0153)
BRN52_RS02855	COG0596	Alpha beta hydrolase
BRN52_RS02870	COG3177	Filamentation induced by cAMP protein fic
BRN52_RS02875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN52_RS02890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRN52_RS02915	COG4191	Histidine kinase
BRN52_RS02920	COG0028	Belongs to the TPP enzyme family
BRN52_RS02935	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRN52_RS02940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN52_RS02970	COG5383	Protein conserved in bacteria
BRN52_RS02985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_RS02990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_RS02995	COG1473	amidohydrolase
BRN52_RS03005	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRN52_RS03005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRN52_RS03020	COG3328	transposase activity
BRN52_RS03120	COG0358	DNA primase activity
BRN52_RS03125	COG1295	ribonuclease BN
BRN52_RS03145	COG1610	YqeY-like protein
BRN52_RS03155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRN52_RS03160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRN52_RS03220	COG2133	pyrroloquinoline quinone binding
BRN52_RS03230	COG4682	membrane
BRN52_RS03255	COG0531	amino acid
BRN52_RS03285	COG4948	Mandelate Racemase Muconate Lactonizing
BRN52_RS03295	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRN52_RS03300	COG3039	Transposase
BRN52_RS03305	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRN52_RS03350	COG3039	Transposase
BRN52_RS03395	COG0183	Belongs to the thiolase family
BRN52_RS03430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRN52_RS03440	COG3483	tryptophan 2,3-dioxygenase activity
BRN52_RS03445	COG3104	oligopeptide transport
BRN52_RS03475	COG1320	monovalent cation:proton antiporter activity
BRN52_RS03480	COG2212	antiporter activity
BRN52_RS03490	COG0651	ATP synthesis coupled electron transport
BRN52_RS03495	COG1006	Multisubunit Na H antiporter MnhC subunit
BRN52_RS03500	COG2111	Na H antiporter
BRN52_RS03500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN52_RS03535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRN52_RS03545	COG0456	acetyltransferase
BRN52_RS03575	COG4221	oxidoreductase activity
BRN52_RS03635	COG0697	spore germination
BRN52_RS03640	COG4305	rare lipoprotein A
BRN52_RS03645	COG5297	Belongs to the glycosyl hydrolase family 6
BRN52_RS03655	COG1113	amino acid transport
BRN52_RS03665	COG0598	Magnesium transport protein CorA
BRN52_RS03735	COG0840	transmembrane signaling receptor activity
BRN52_RS03745	COG5297	Belongs to the glycosyl hydrolase family 6
BRN52_RS03745	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_RS03750	COG0659	secondary active sulfate transmembrane transporter activity
BRN52_RS03800	COG3275	phosphorelay sensor kinase activity
BRN52_RS03810	COG0181	hydroxymethylbilane synthase activity
BRN52_RS03835	COG1505	serine-type exopeptidase activity
BRN52_RS03850	COG0436	Aminotransferase
BRN52_RS03880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRN52_RS03910	COG0308	aminopeptidase N
BRN52_RS03915	COG2199	diguanylate cyclase activity
BRN52_RS03965	COG3039	Transposase
BRN52_RS03970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN52_RS03975	COG1077	Cell shape determining protein MreB Mrl
BRN52_RS03980	COG1792	Involved in formation and maintenance of cell shape
BRN52_RS03995	COG0772	Belongs to the SEDS family
BRN52_RS04065	COG2951	lytic endotransglycosylase activity
BRN52_RS04070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRN52_RS04080	COG1686	Belongs to the peptidase S11 family
BRN52_RS04090	COG2921	Belongs to the UPF0250 family
BRN52_RS04115	COG1056	cytidyltransferase-related domain
BRN52_RS04115	COG1051	belongs to the nudix hydrolase family
BRN52_RS04150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRN52_RS04155	COG0673	inositol 2-dehydrogenase activity
BRN52_RS04160	COG2823	Periplasmic or secreted lipoprotein
BRN52_RS04165	COG4251	negative regulation of phosphorylation
BRN52_RS04170	COG0784	Response regulator, receiver
BRN52_RS04175	COG4191	Histidine kinase
BRN52_RS04180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRN52_RS04235	COG3250	beta-galactosidase activity
BRN52_RS04250	COG2188	Transcriptional regulator
BRN52_RS04260	COG1609	Transcriptional regulator
BRN52_RS04265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN52_RS04270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRN52_RS04280	COG1215	transferase activity, transferring glycosyl groups
BRN52_RS04285	COG1649	PFAM Uncharacterised BCR, COG1649
BRN52_RS04285	COG0726	polysaccharide deacetylase
BRN52_RS04405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRN52_RS04410	COG3039	Transposase
BRN52_RS04445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRN52_RS04460	COG2205	protein histidine kinase activity
BRN52_RS04500	COG2205	protein histidine kinase activity
BRN52_RS04555	COG0488	(ABC) transporter
BRN52_RS04575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRN52_RS04595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN52_RS04595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN52_RS04615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRN52_RS04620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRN52_RS04625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRN52_RS04650	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRN52_RS04655	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRN52_RS04665	COG2205	protein histidine kinase activity
BRN52_RS04670	COG0745	RESPONSE REGULATOR receiver
BRN52_RS04675	COG0277	FAD linked oxidase domain protein
BRN52_RS04680	COG1988	membrane-bound metal-dependent
BRN52_RS04685	COG0792	nuclease activity
BRN52_RS04720	COG0275	rRNA processing
BRN52_RS04725	COG3116	cell division
BRN52_RS04740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRN52_RS04760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRN52_RS04765	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN52_RS04770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRN52_RS04785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRN52_RS04795	COG4942	peptidase
BRN52_RS04795	COG1388	LysM domain
BRN52_RS04810	COG0494	nUDIX hydrolase
BRN52_RS04835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRN52_RS04850	COG0604	alcohol dehydrogenase
BRN52_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS04850	COG3321	synthase
BRN52_RS04905	COG2226	methyltransferase
BRN52_RS04910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRN52_RS04950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRN52_RS04965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN52_RS04985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN52_RS04990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRN52_RS05000	COG0667	Aldo Keto reductase
BRN52_RS05050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BRN52_RS05060	COG2175	clavaminate synthase activity
BRN52_RS05070	COG4181	ATPase activity
BRN52_RS05085	COG0642	Histidine kinase
BRN52_RS05100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRN52_RS05120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRN52_RS05145	COG2967	ApaG domain
BRN52_RS05150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRN52_RS05160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRN52_RS05175	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRN52_RS05180	COG2096	Adenosyltransferase
BRN52_RS05190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN52_RS05195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN52_RS05235	COG0583	DNA-binding transcription factor activity
BRN52_RS05240	COG0318	PFAM AMP-dependent synthetase and ligase
BRN52_RS05250	COG1024	Enoyl-CoA hydratase
BRN52_RS05270	COG3386	PFAM SMP-30 Gluconolaconase
BRN52_RS05385	COG2197	response regulator
BRN52_RS05440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BRN52_RS05445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN52_RS05455	COG0583	DNA-binding transcription factor activity
BRN52_RS05460	COG3634	alkyl hydroperoxide reductase activity
BRN52_RS05470	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN52_RS05510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN52_RS05510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN52_RS05525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN52_RS05550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRN52_RS05580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRN52_RS05595	COG1404	Belongs to the peptidase S8 family
BRN52_RS05600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRN52_RS05630	COG1295	ribonuclease BN
BRN52_RS05635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN52_RS05655	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRN52_RS05665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRN52_RS05680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BRN52_RS05695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRN52_RS05705	COG0193	aminoacyl-tRNA hydrolase activity
BRN52_RS05710	COG0012	GTP binding
BRN52_RS05740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRN52_RS05745	COG0250	Participates in transcription elongation, termination and antitermination
BRN52_RS05755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRN52_RS05765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRN52_RS05770	COG0222	ribosome binding
BRN52_RS05775	COG0085	RNA polymerase activity
BRN52_RS05780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRN52_RS05785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRN52_RS05790	COG0049	tRNA binding
BRN52_RS05810	COG0051	transcription antitermination factor activity, RNA binding
BRN52_RS05815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRN52_RS05820	COG0088	Forms part of the polypeptide exit tunnel
BRN52_RS05825	COG0089	rRNA binding
BRN52_RS05840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRN52_RS05850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRN52_RS05855	COG0255	Belongs to the universal ribosomal protein uL29 family
BRN52_RS05860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRN52_RS05865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRN52_RS05870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BRN52_RS05875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRN52_RS05895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BRN52_RS05905	COG1841	ribosomal large subunit assembly
BRN52_RS05915	COG0201	protein transport
BRN52_RS05925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRN52_RS05930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRN52_RS05940	COG0203	ribosomal protein L17
BRN52_RS06005	COG3551	Protein conserved in bacteria
BRN52_RS06035	COG2194	sulfuric ester hydrolase activity
BRN52_RS06045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRN52_RS06050	COG0745	RESPONSE REGULATOR receiver
BRN52_RS06055	COG0642	Histidine kinase
BRN52_RS06065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRN52_RS06070	COG2894	cell division
BRN52_RS06090	COG4585	Histidine kinase
BRN52_RS06095	COG2197	response regulator
BRN52_RS06110	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRN52_RS06140	COG2963	transposase activity
BRN52_RS06200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_RS06210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_RS06250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_RS06470	COG0732	type I restriction modification DNA specificity domain
BRN52_RS06485	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRN52_RS06505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRN52_RS06510	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRN52_RS06520	COG0732	type I restriction modification DNA specificity domain
BRN52_RS06525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRN52_RS06610	COG0587	DNA-directed DNA polymerase activity
BRN52_RS06630	COG1297	OPT oligopeptide transporter protein
BRN52_RS06655	COG0823	Involved in the tonB-independent uptake of proteins
BRN52_RS06655	COG1506	peptidase
BRN52_RS06675	COG1917	Cupin 2, conserved barrel domain protein
BRN52_RS06675	COG2207	Transcriptional regulator
BRN52_RS06705	COG0753	catalase activity
BRN52_RS06720	COG3039	Transposase
BRN52_RS06755	COG0126	phosphoglycerate kinase activity
BRN52_RS06765	COG0469	pyruvate kinase activity
BRN52_RS06775	COG3588	fructose-bisphosphate aldolase
BRN52_RS06780	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRN52_RS06835	COG2205	protein histidine kinase activity
BRN52_RS06835	COG2198	Histidine kinase
BRN52_RS06835	COG0784	Response regulator, receiver
BRN52_RS06855	COG0175	sulfate reduction
BRN52_RS06860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRN52_RS06865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN52_RS06870	COG0175	sulfate reduction
BRN52_RS06875	COG0529	Catalyzes the synthesis of activated sulfate
BRN52_RS06875	COG2895	sulfate adenylyltransferase (ATP) activity
BRN52_RS06890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_RS06895	COG0308	aminopeptidase N
BRN52_RS06925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN52_RS06960	COG1970	mechanosensitive ion channel activity
BRN52_RS06995	COG3273	potassium ion transport
BRN52_RS06995	COG0471	metal ion transport
BRN52_RS07010	COG2022	thiamine diphosphate biosynthetic process
BRN52_RS07110	COG3039	Transposase
BRN52_RS07135	COG3039	Transposase
BRN52_RS07195	COG3118	belongs to the thioredoxin family
BRN52_RS07225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRN52_RS07250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRN52_RS07280	COG3039	Transposase
BRN52_RS07290	COG2968	Membrane
BRN52_RS07305	COG3164	Protein of unknown function
BRN52_RS07315	COG0312	modulator of DNA gyrase
BRN52_RS07325	COG0312	modulator of DNA gyrase
BRN52_RS07350	COG0142	geranyltranstransferase activity
BRN52_RS07355	COG1722	exodeoxyribonuclease VII activity
BRN52_RS07360	COG0037	tRNA processing
BRN52_RS07365	COG1785	Belongs to the alkaline phosphatase family
BRN52_RS07370	COG1301	dicarboxylic acid transport
BRN52_RS07385	COG0791	NLP P60 protein
BRN52_RS07390	COG0791	NLP P60 protein
BRN52_RS07395	COG1047	Peptidyl-prolyl cis-trans
BRN52_RS07400	COG2311	Membrane
BRN52_RS07405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_RS07450	COG0489	protein tyrosine kinase activity
BRN52_RS07455	COG0717	Belongs to the dCTP deaminase family
BRN52_RS07475	COG0412	Dienelactone hydrolase
BRN52_RS07485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN52_RS07535	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN52_RS07540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRN52_RS07545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRN52_RS07550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRN52_RS07570	COG0101	tRNA pseudouridine synthase activity
BRN52_RS07575	COG0135	phosphoribosylanthranilate isomerase activity
BRN52_RS07585	COG0133	tryptophan synthase activity
BRN52_RS07600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRN52_RS07605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRN52_RS07655	COG0149	triose-phosphate isomerase activity
BRN52_RS07670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRN52_RS07680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRN52_RS07685	COG0649	NAD binding
BRN52_RS07690	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRN52_RS07695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRN52_RS07700	COG1034	ATP synthesis coupled electron transport
BRN52_RS07705	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BRN52_RS07735	COG1007	ATP synthesis coupled electron transport
BRN52_RS07745	COG0779	Required for maturation of 30S ribosomal subunits
BRN52_RS07750	COG0195	Participates in both transcription termination and antitermination
BRN52_RS07770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRN52_RS07775	COG1185	polyribonucleotide nucleotidyltransferase activity
BRN52_RS07810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN52_RS07820	COG2095	MarC family integral membrane protein
BRN52_RS07835	COG1611	Belongs to the LOG family
BRN52_RS07840	COG3039	Transposase
BRN52_RS07885	COG4969	Belongs to the N-Me-Phe pilin family
BRN52_RS07890	COG0556	nucleotide-excision repair
BRN52_RS07935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRN52_RS07945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BRN52_RS07950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BRN52_RS08005	COG0438	transferase activity, transferring glycosyl groups
BRN52_RS08010	COG0438	transferase activity, transferring glycosyl groups
BRN52_RS08020	COG0438	transferase activity, transferring glycosyl groups
BRN52_RS08060	COG3040	lipid binding
BRN52_RS08190	COG0552	protein localization to endoplasmic reticulum
BRN52_RS08200	COG3938	Belongs to the proline racemase family
BRN52_RS08205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_RS08220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN52_RS08230	COG0006	proline dipeptidase activity
BRN52_RS08245	COG0531	amino acid
BRN52_RS08295	COG4206	TonB-dependent receptor
BRN52_RS08325	COG4206	TonB-dependent receptor
BRN52_RS08395	COG0746	molybdenum cofactor guanylyltransferase activity
BRN52_RS08420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRN52_RS08420	COG1648	precorrin-2 dehydrogenase activity
BRN52_RS08450	COG3039	Transposase
BRN52_RS08490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRN52_RS08510	COG1054	Belongs to the UPF0176 family
BRN52_RS08530	COG1530	ribonuclease E activity
BRN52_RS08540	COG3064	Membrane
BRN52_RS08545	COG0428	transporter
BRN52_RS08550	COG0428	transporter
BRN52_RS08640	COG3039	Transposase
BRN52_RS08765	COG0631	protein serine/threonine phosphatase activity
BRN52_RS08770	COG0515	serine threonine protein kinase
BRN52_RS08800	COG1858	cytochrome C peroxidase
BRN52_RS08855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_RS08860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_RS08910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN52_RS08930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN52_RS08945	COG1595	DNA-templated transcription, initiation
BRN52_RS08995	COG2244	polysaccharide biosynthetic process
BRN52_RS09025	COG2264	protein methyltransferase activity
BRN52_RS09035	COG0438	transferase activity, transferring glycosyl groups
BRN52_RS09050	COG1136	(ABC) transporter
BRN52_RS09055	COG1132	(ABC) transporter
BRN52_RS09065	COG0477	Major facilitator Superfamily
BRN52_RS09085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRN52_RS09100	COG1253	flavin adenine dinucleotide binding
BRN52_RS09115	COG0306	phosphate transporter
BRN52_RS09145	COG0504	CTP synthase activity
BRN52_RS09150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRN52_RS09160	COG0148	phosphopyruvate hydratase activity
BRN52_RS09165	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRN52_RS09170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BRN52_RS09180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRN52_RS09195	COG2840	Smr protein MutS2
BRN52_RS09200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRN52_RS09205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRN52_RS09210	COG1238	metal cluster binding
BRN52_RS09225	COG1534	Rna-binding protein
BRN52_RS09230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRN52_RS09240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRN52_RS09255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRN52_RS09260	COG1546	Belongs to the CinA family
BRN52_RS09275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRN52_RS09285	COG2137	regulation of response to DNA damage stimulus
BRN52_RS09290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRN52_RS09295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRN52_RS09320	COG0305	Participates in initiation and elongation during chromosome replication
BRN52_RS09325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRN52_RS09345	COG1741	Belongs to the pirin family
BRN52_RS09350	COG0583	DNA-binding transcription factor activity
BRN52_RS09380	COG0351	phosphomethylpyrimidine kinase
BRN52_RS09390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRN52_RS09395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRN52_RS09410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN52_RS09420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRN52_RS09425	COG3734	2-keto-3-deoxy-galactonokinase
BRN52_RS09435	COG4948	Mandelate Racemase Muconate Lactonizing
BRN52_RS09440	COG0800	Aldolase
BRN52_RS09455	COG1501	Belongs to the glycosyl hydrolase 31 family
BRN52_RS09465	COG1070	Carbohydrate kinase
BRN52_RS09475	COG0477	Major facilitator Superfamily
BRN52_RS09495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRN52_RS09545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRN52_RS09550	COG2258	MOSC domain
BRN52_RS09560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRN52_RS09565	COG0505	Belongs to the CarA family
BRN52_RS09575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRN52_RS09580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN52_RS09590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRN52_RS09675	COG0784	Response regulator, receiver
BRN52_RS09675	COG2198	Histidine kinase
BRN52_RS09675	COG2205	protein histidine kinase activity
BRN52_RS09680	COG1024	Enoyl-CoA hydratase
BRN52_RS09685	COG0318	PFAM AMP-dependent synthetase and ligase
BRN52_RS09715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN52_RS09750	COG0840	transmembrane signaling receptor activity
BRN52_RS09775	COG0835	chemotaxis
BRN52_RS09795	COG0840	transmembrane signaling receptor activity
BRN52_RS09800	COG0840	transmembrane signaling receptor activity
BRN52_RS09805	COG0840	transmembrane signaling receptor activity
BRN52_RS09810	COG0840	transmembrane signaling receptor activity
BRN52_RS09820	COG0840	transmembrane signaling receptor activity
BRN52_RS09835	COG0840	transmembrane signaling receptor activity
BRN52_RS09850	COG0840	transmembrane signaling receptor activity
BRN52_RS09875	COG0745	RESPONSE REGULATOR receiver
BRN52_RS09885	COG0835	chemotaxis
BRN52_RS09895	COG1360	Flagellar Motor Protein
BRN52_RS09900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRN52_RS09920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN52_RS09930	COG4771	TonB-dependent receptor
BRN52_RS10065	COG3039	Transposase
BRN52_RS10080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN52_RS10080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN52_RS10085	COG1105	Belongs to the carbohydrate kinase PfkB family
BRN52_RS10090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN52_RS10090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN52_RS10095	COG1609	Transcriptional regulator
BRN52_RS10115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_RS10120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_RS10130	COG2902	Dehydrogenase
BRN52_RS10140	COG3039	Transposase
BRN52_RS10150	COG0784	Response regulator, receiver
BRN52_RS10150	COG2205	protein histidine kinase activity
BRN52_RS10150	COG5002	protein histidine kinase activity
BRN52_RS10155	COG2733	membrane
BRN52_RS10165	COG1121	(ABC) transporter
BRN52_RS10170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRN52_RS10180	COG2223	nitrite transmembrane transporter activity
BRN52_RS10190	COG0243	molybdopterin cofactor binding
BRN52_RS10200	COG0477	Major facilitator Superfamily
BRN52_RS10210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_RS10215	COG0174	glutamine synthetase
BRN52_RS10255	COG3842	ATPase activity
BRN52_RS10265	COG1177	transmembrane transport
BRN52_RS10275	COG1012	belongs to the aldehyde dehydrogenase family
BRN52_RS10290	COG4535	Mg2 and Co2 transporter CorC
BRN52_RS10310	COG1702	phosphate starvation-inducible protein PhoH
BRN52_RS10335	COG0741	lytic transglycosylase activity
BRN52_RS10345	COG0723	plastoquinol--plastocyanin reductase activity
BRN52_RS10350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRN52_RS10355	COG2857	Cytochrome c1
BRN52_RS10360	COG0625	glutathione transferase activity
BRN52_RS10365	COG2969	positive regulation of protein catabolic process
BRN52_RS10410	COG3328	transposase activity
BRN52_RS10415	COG3039	Transposase
BRN52_RS10505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_RS10525	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN52_RS10530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRN52_RS10530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRN52_RS10535	COG0802	atpase or kinase
BRN52_RS10540	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN52_RS10545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRN52_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS10590	COG2081	HI0933 family
BRN52_RS10595	COG4681	YaeQ
BRN52_RS10600	COG1671	Belongs to the UPF0178 family
BRN52_RS10610	COG0625	glutathione transferase activity
BRN52_RS10620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BRN52_RS10630	COG0513	Belongs to the DEAD box helicase family
BRN52_RS10635	COG0488	(ABC) transporter
BRN52_RS10660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN52_RS10665	COG0483	inositol monophosphate 1-phosphatase activity
BRN52_RS10680	COG5001	Diguanylate cyclase
BRN52_RS10680	COG3300	MHYT domain
BRN52_RS10685	COG1509	lysine 2,3-aminomutase activity
BRN52_RS10700	COG0402	S-adenosylhomocysteine deaminase activity
BRN52_RS10705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRN52_RS10730	COG4677	pectinesterase activity
BRN52_RS10755	COG3039	Transposase
BRN52_RS10790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRN52_RS10815	COG2166	iron-sulfur cluster assembly
BRN52_RS10830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRN52_RS10835	COG0137	argininosuccinate synthase activity
BRN52_RS10845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN52_RS10850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRN52_RS10865	COG0165	Argininosuccinate lyase
BRN52_RS10885	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRN52_RS10915	COG1271	oxidase subunit
BRN52_RS10925	COG4988	ABC transporter
BRN52_RS10930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRN52_RS11040	COG3209	COG3209 Rhs family protein
BRN52_RS11075	COG0643	Histidine kinase
BRN52_RS11075	COG0784	Response regulator, receiver
BRN52_RS11075	COG2198	Histidine kinase
BRN52_RS11130	COG1684	flagellar biosynthetic protein fliR
BRN52_RS11150	COG3190	flagellar
BRN52_RS11200	COG1677	Flagellar hook-basal body complex protein FliE
BRN52_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS11250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN52_RS11270	COG2201	protein-glutamate methylesterase activity
BRN52_RS11300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRN52_RS11305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRN52_RS11345	COG4787	bacterial-type flagellum-dependent cell motility
BRN52_RS11355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRN52_RS11360	COG1558	bacterial-type flagellum-dependent cell motility
BRN52_RS11370	COG0784	Response regulator, receiver
BRN52_RS11370	COG0835	chemotaxis
BRN52_RS11390	COG5002	protein histidine kinase activity
BRN52_RS11400	COG4585	Histidine kinase
BRN52_RS11405	COG5001	Diguanylate cyclase
BRN52_RS11445	COG0542	response to heat
BRN52_RS11470	COG0492	ferredoxin-NADP+ reductase activity
BRN52_RS11475	COG1674	ftsk spoiiie
BRN52_RS11500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRN52_RS11520	COG0038	chloride channel
BRN52_RS11525	COG0183	Belongs to the thiolase family
BRN52_RS11530	COG1024	Enoyl-CoA hydratase
BRN52_RS11530	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN52_RS11545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRN52_RS11555	COG1426	Protein conserved in bacteria
BRN52_RS11565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_RS11575	COG0303	'Molybdopterin
BRN52_RS11655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRN52_RS11670	COG3039	Transposase
BRN52_RS11700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BRN52_RS11710	COG0531	amino acid
BRN52_RS11715	COG0531	amino acid
BRN52_RS11725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRN52_RS11730	COG0277	FAD linked oxidase domain protein
BRN52_RS11795	COG0436	Aminotransferase
BRN52_RS11820	COG1187	pseudouridine synthase activity
BRN52_RS11825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRN52_RS11830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRN52_RS11835	COG2350	Protein conserved in bacteria
BRN52_RS11865	COG1175	transmembrane transport
BRN52_RS11870	COG0395	ABC-type sugar transport system, permease component
BRN52_RS11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN52_RS11905	COG2957	Belongs to the agmatine deiminase family
BRN52_RS11920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRN52_RS11925	COG0539	negative regulation of cytoplasmic translation
BRN52_RS11930	COG0776	regulation of translation
BRN52_RS11940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRN52_RS11945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN52_RS11955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRN52_RS11975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRN52_RS11995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN52_RS12000	COG0583	DNA-binding transcription factor activity
BRN52_RS12030	COG0583	DNA-binding transcription factor activity
BRN52_RS12035	COG0583	DNA-binding transcription factor activity
BRN52_RS12055	COG1914	H( )-stimulated, divalent metal cation uptake system
BRN52_RS12075	COG0668	transmembrane transport
BRN52_RS12100	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS12105	COG1183	phosphatidylcholine synthase activity
BRN52_RS12115	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRN52_RS12130	COG0723	plastoquinol--plastocyanin reductase activity
BRN52_RS12130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_RS12140	COG2183	response to ionizing radiation
BRN52_RS12155	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRN52_RS12170	COG0671	phosphoesterase, PA-phosphatase related
BRN52_RS12195	COG1794	racemase activity, acting on amino acids and derivatives
BRN52_RS12200	COG0697	spore germination
BRN52_RS12225	COG1012	belongs to the aldehyde dehydrogenase family
BRN52_RS12260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRN52_RS12275	COG0124	histidyl-tRNA synthetase
BRN52_RS12295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRN52_RS12310	COG0131	Imidazoleglycerol-phosphate dehydratase
BRN52_RS12310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BRN52_RS12320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRN52_RS12330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRN52_RS12330	COG0140	phosphoribosyl-ATP diphosphatase activity
BRN52_RS12430	COG0653	protein targeting
BRN52_RS12475	COG2201	protein-glutamate methylesterase activity
BRN52_RS12485	COG2801	Transposase and inactivated derivatives
BRN52_RS12550	COG0322	excinuclease ABC activity
BRN52_RS12560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRN52_RS12570	COG1663	tetraacyldisaccharide 4'-kinase activity
BRN52_RS12585	COG0811	peptide transport
BRN52_RS12615	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRN52_RS12630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRN52_RS12645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRN52_RS12660	COG0354	folic acid binding
BRN52_RS12675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN52_RS12685	COG0363	glucosamine-6-phosphate deaminase activity
BRN52_RS12690	COG0129	dihydroxy-acid dehydratase activity
BRN52_RS12695	COG0800	Aldolase
BRN52_RS12730	COG5002	protein histidine kinase activity
BRN52_RS12730	COG0784	Response regulator, receiver
BRN52_RS12730	COG2205	protein histidine kinase activity
BRN52_RS12750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN52_RS12755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BRN52_RS12760	COG0431	NADPH-dependent FMN reductase
BRN52_RS12765	COG1393	Belongs to the ArsC family
BRN52_RS12770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRN52_RS12785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN52_RS12815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRN52_RS12840	COG1247	-acetyltransferase
BRN52_RS12915	COG0386	Belongs to the glutathione peroxidase family
BRN52_RS13005	COG2203	Gaf domain
BRN52_RS13005	COG5001	Diguanylate cyclase
BRN52_RS13005	COG4251	negative regulation of phosphorylation
BRN52_RS13005	COG3706	GGDEF domain
BRN52_RS13025	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN52_RS13065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BRN52_RS13085	COG1469	GTP cyclohydrolase I activity
BRN52_RS13090	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN52_RS13140	COG4566	intracellular signal transduction
BRN52_RS13175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRN52_RS13180	COG1605	Chorismate mutase
BRN52_RS13180	COG0077	Prephenate dehydratase
BRN52_RS13190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRN52_RS13235	COG1228	amidohydrolase
BRN52_RS13240	COG2986	histidine ammonia-lyase
BRN52_RS13250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRN52_RS13275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRN52_RS13290	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRN52_RS13305	COG3115	cell septum assembly
BRN52_RS13315	COG0359	binds to the 23S rRNA
BRN52_RS13325	COG0360	Binds together with S18 to 16S ribosomal RNA
BRN52_RS13330	COG0316	Belongs to the HesB IscA family
BRN52_RS13365	COG0288	reversible hydration of carbon dioxide
BRN52_RS13395	COG2925	Exonuclease
BRN52_RS13405	COG0667	Aldo Keto reductase
BRN52_RS13430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRN52_RS13430	COG0116	Belongs to the methyltransferase superfamily
BRN52_RS13475	COG0494	nUDIX hydrolase
BRN52_RS13485	COG1024	Enoyl-CoA hydratase
BRN52_RS13495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRN52_RS13530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRN52_RS13535	COG0573	inorganic phosphate transmembrane transporter activity
BRN52_RS13550	COG0704	Plays a role in the regulation of phosphate uptake
BRN52_RS13560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN52_RS13580	COG3328	transposase activity
BRN52_RS13610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRN52_RS13615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRN52_RS13620	COG1862	Preprotein translocase
BRN52_RS13625	COG0343	queuine tRNA-ribosyltransferase activity
BRN52_RS13665	COG3039	Transposase
BRN52_RS13810	COG0405	Gamma-glutamyltransferase
BRN52_RS13815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRN52_RS13830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRN52_RS13835	COG0742	ribosomal rna small subunit methyltransferase
BRN52_RS13915	COG0583	DNA-binding transcription factor activity
BRN52_RS13925	COG3039	Transposase
BRN52_RS14005	COG1278	Cold shock
BRN52_RS14055	COG3039	Transposase
BRN52_RS14070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN52_RS14085	COG0557	exoribonuclease II activity
BRN52_RS14115	COG1960	acyl-CoA dehydrogenase activity
BRN52_RS14120	COG2226	methyltransferase
BRN52_RS14125	COG1410	methionine synthase
BRN52_RS14125	COG0646	methionine synthase
BRN52_RS14130	COG0646	methionine synthase
BRN52_RS14130	COG1410	methionine synthase
BRN52_RS14140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN52_RS14150	COG1609	Transcriptional regulator
BRN52_RS14165	COG2900	Belongs to the SlyX family
BRN52_RS14180	COG0386	Belongs to the glutathione peroxidase family
BRN52_RS14190	COG1725	Transcriptional regulator
BRN52_RS14195	COG1131	(ABC) transporter
BRN52_RS14290	COG2850	peptidyl-arginine hydroxylation
BRN52_RS14325	COG1132	(ABC) transporter
BRN52_RS14340	COG0583	DNA-binding transcription factor activity
BRN52_RS14360	COG0287	Prephenate dehydrogenase
BRN52_RS14360	COG1605	Chorismate mutase
BRN52_RS14365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRN52_RS14375	COG0484	heat shock protein binding
BRN52_RS14385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRN52_RS14395	COG0497	DNA recombination
BRN52_RS14405	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_RS14415	COG2914	Belongs to the UPF0125 (RnfH) family
BRN52_RS14425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BRN52_RS14440	COG1960	acyl-CoA dehydrogenase activity
BRN52_RS14450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRN52_RS14495	COG2814	Major facilitator Superfamily
BRN52_RS14500	COG1566	PFAM secretion protein HlyD family protein
BRN52_RS14515	COG2207	Transcriptional regulator
BRN52_RS14550	COG4774	siderophore transport
BRN52_RS14565	COG0367	asparagine synthase
BRN52_RS14570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN52_RS14580	COG1393	Belongs to the ArsC family
BRN52_RS14640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRN52_RS14655	COG0233	cytoplasmic translational termination
BRN52_RS14665	COG0575	Belongs to the CDS family
BRN52_RS14675	COG0750	zinc metalloprotease
BRN52_RS14690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRN52_RS14695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRN52_RS14715	COG0825	malonyl-CoA metabolic process
BRN52_RS14725	COG4771	TonB-dependent receptor
BRN52_RS14730	COG1131	(ABC) transporter
BRN52_RS14765	COG1981	membrane
BRN52_RS14810	COG0529	Catalyzes the synthesis of activated sulfate
BRN52_RS14810	COG2895	sulfate adenylyltransferase (ATP) activity
BRN52_RS14845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN52_RS14865	COG2040	homocysteine
BRN52_RS14870	COG0833	amino acid
BRN52_RS14890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRN52_RS14890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRN52_RS14900	COG2878	Part of a membrane complex involved in electron transport
BRN52_RS14920	COG1595	DNA-templated transcription, initiation
BRN52_RS14945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN52_RS14960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN52_RS14965	COG0251	oxidation-reduction process
BRN52_RS14975	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRN52_RS14975	COG0392	lysyltransferase activity
BRN52_RS15020	COG2814	Major facilitator Superfamily
BRN52_RS15025	COG1902	pentaerythritol trinitrate reductase activity
BRN52_RS15040	COG2824	Alkylphosphonate utilization operon protein PhnA
BRN52_RS15055	COG1047	Peptidyl-prolyl cis-trans
BRN52_RS15095	COG3039	Transposase
BRN52_RS15100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN52_RS15115	COG1451	nucleotide metabolic process
BRN52_RS15140	COG0183	Belongs to the thiolase family
BRN52_RS15170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRN52_RS15170	COG1793	dna ligase
BRN52_RS15180	COG1793	dna ligase
BRN52_RS15185	COG1201	RNA secondary structure unwinding
BRN52_RS15205	COG1278	Cold shock
BRN52_RS15210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRN52_RS15215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BRN52_RS15225	COG3046	protein related to deoxyribodipyrimidine photolyase
BRN52_RS15230	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRN52_RS15235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRN52_RS15265	COG2954	triphosphatase activity
BRN52_RS15280	COG1381	Involved in DNA repair and RecF pathway recombination
BRN52_RS15310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN52_RS15325	COG1024	Enoyl-CoA hydratase
BRN52_RS15325	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN52_RS15345	COG1024	Enoyl-CoA hydratase
BRN52_RS15350	COG1960	acyl-CoA dehydrogenase activity
BRN52_RS15425	COG2353	YceI-like domain
BRN52_RS15435	COG2353	YceI-like domain
BRN52_RS15450	COG1760	l-serine dehydratase
BRN52_RS15460	COG0626	cystathionine gamma-synthase activity
BRN52_RS15465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN52_RS15470	COG0739	heme binding
BRN52_RS15480	COG1272	protein, Hemolysin III
BRN52_RS15510	COG0463	Glycosyl transferase, family 2
BRN52_RS15520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRN52_RS15530	COG4771	TonB-dependent receptor
BRN52_RS15535	COG1309	transcriptional regulator
BRN52_RS15545	COG1960	acyl-CoA dehydrogenase activity
BRN52_RS15580	COG0509	glycine decarboxylation via glycine cleavage system
BRN52_RS15595	COG0330	HflC and HflK could
BRN52_RS15610	COG3956	TIGRFAM MazG family protein
BRN52_RS15620	COG0494	nUDIX hydrolase
BRN52_RS15630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRN52_RS15635	COG0837	glucose binding
BRN52_RS15650	COG1388	LysM domain
BRN52_RS15650	COG3858	chitin binding
BRN52_RS15670	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN52_RS15735	COG3537	Alpha-1,2-mannosidase
BRN52_RS15790	COG1446	asparaginase
BRN52_RS15845	COG0643	Histidine kinase
BRN52_RS15845	COG2198	Histidine kinase
BRN52_RS15845	COG0784	Response regulator, receiver
BRN52_RS15850	COG0840	transmembrane signaling receptor activity
BRN52_RS15855	COG0835	chemotaxis
BRN52_RS15870	COG0189	ligase activity
BRN52_RS15880	COG1397	ADP-ribosylglycohydrolase
BRN52_RS15890	COG1199	ATP-dependent helicase activity
BRN52_RS15900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRN52_RS15905	COG1215	transferase activity, transferring glycosyl groups
BRN52_RS15915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN52_RS15935	COG0535	radical SAM domain protein
BRN52_RS15940	COG0535	radical SAM domain protein
BRN52_RS15965	COG1643	Atp-dependent helicase
BRN52_RS15970	COG0783	Belongs to the Dps family
BRN52_RS15980	COG0514	ATP-dependent DNA helicase (RecQ)
BRN52_RS16005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRN52_RS16030	COG0602	queuosine metabolic process
BRN52_RS16040	COG2885	chlorophyll binding
BRN52_RS16055	COG0848	biopolymer transport protein
BRN52_RS16065	COG0824	Thioesterase
BRN52_RS16070	COG2255	four-way junction helicase activity
BRN52_RS16080	COG0632	four-way junction helicase activity
BRN52_RS16215	COG3039	Transposase
BRN52_RS16220	COG3209	COG3209 Rhs family protein
BRN52_RS16225	COG3039	Transposase
BRN52_RS16245	COG3039	Transposase
BRN52_RS16300	COG3209	COG3209 Rhs family protein
BRN52_RS16320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRN52_RS16325	COG1845	cytochrome c oxidase, subunit III
BRN52_RS16330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRN52_RS16345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRN52_RS16350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRN52_RS16360	COG0196	riboflavin kinase activity
BRN52_RS16365	COG0728	peptidoglycan biosynthetic process
BRN52_RS16370	COG0268	Binds directly to 16S ribosomal RNA
BRN52_RS16375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRN52_RS16380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRN52_RS16390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRN52_RS16395	COG0824	Thioesterase
BRN52_RS16410	COG1946	Acyl-CoA thioesterase
BRN52_RS16420	COG1595	DNA-templated transcription, initiation
BRN52_RS16435	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BRN52_RS16475	COG1877	trehalose-phosphatase activity
BRN52_RS16480	COG3387	PFAM Glycoside hydrolase 15-related
BRN52_RS16505	COG0564	pseudouridine synthase activity
BRN52_RS16510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_RS16515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRN52_RS16515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN52_RS16525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRN52_RS16530	COG0045	succinate-CoA ligase (ADP-forming) activity
BRN52_RS16570	COG2194	sulfuric ester hydrolase activity
BRN52_RS16575	COG4969	Belongs to the N-Me-Phe pilin family
BRN52_RS16585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRN52_RS16620	COG3039	Transposase
BRN52_RS16650	COG1132	(ABC) transporter
BRN52_RS16680	COG0745	RESPONSE REGULATOR receiver
BRN52_RS16685	COG5002	protein histidine kinase activity
BRN52_RS16685	COG5000	phosphorelay sensor kinase activity
BRN52_RS16690	COG0475	glutathione-regulated potassium exporter activity
BRN52_RS16700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRN52_RS16725	COG1187	pseudouridine synthase activity
BRN52_RS16730	COG5002	protein histidine kinase activity
BRN52_RS16730	COG5001	Diguanylate cyclase
BRN52_RS16850	COG0415	Belongs to the DNA photolyase family
BRN52_RS16855	COG0305	Participates in initiation and elongation during chromosome replication
BRN52_RS16865	COG0367	asparagine synthase
BRN52_RS16880	COG1960	acyl-CoA dehydrogenase activity
BRN52_RS16895	COG0084	hydrolase, TatD family'
BRN52_RS16900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRN52_RS16960	COG0735	belongs to the Fur family
BRN52_RS16965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRN52_RS16995	COG3039	Transposase
BRN52_RS17030	COG3039	Transposase
BRN52_RS17060	COG2205	protein histidine kinase activity
BRN52_RS17070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRN52_RS17080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRN52_RS17090	COG0643	Histidine kinase
BRN52_RS17090	COG2198	Histidine kinase
BRN52_RS17100	COG0840	transmembrane signaling receptor activity
BRN52_RS17105	COG0835	chemotaxis
BRN52_RS17110	COG2202	Pas domain
BRN52_RS17110	COG2200	EAL domain
BRN52_RS17110	COG2199	diguanylate cyclase activity
BRN52_RS17115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRN52_RS17130	COG3590	peptidase
BRN52_RS17145	COG0588	phosphoglycerate mutase activity
BRN52_RS17150	COG1515	deoxyribonuclease V activity
BRN52_RS17160	COG1741	Belongs to the pirin family
BRN52_RS17235	COG3039	Transposase
BRN52_RS17290	COG1741	Belongs to the pirin family
BRN52_RS17295	COG1966	Carbon starvation protein
BRN52_RS17300	COG2879	small protein
BRN52_RS17340	COG4251	negative regulation of phosphorylation
BRN52_RS17340	COG3706	GGDEF domain
BRN52_RS17340	COG2203	Gaf domain
BRN52_RS17340	COG5001	Diguanylate cyclase
BRN52_RS17345	COG0629	single-stranded DNA binding
BRN52_RS17350	COG0142	geranyltranstransferase activity
BRN52_RS17380	COG0527	aspartate kinase activity
BRN52_RS17390	COG0384	phenazine biosynthesis protein PhzF
BRN52_RS17405	COG1764	response to oxidative stress
BRN52_RS17420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRN52_RS17425	COG1678	Uncharacterized ACR, COG1678
BRN52_RS17435	COG0519	Catalyzes the synthesis of GMP from XMP
BRN52_RS17460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRN52_RS17505	COG0693	protein deglycase activity
BRN52_RS17525	COG1959	2 iron, 2 sulfur cluster binding
BRN52_RS17530	COG0719	Fe-S assembly protein
BRN52_RS17535	COG0396	ATPase activity
BRN52_RS17540	COG0719	Fe-S assembly protein
BRN52_RS17545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRN52_RS17555	COG2146	nitrite reductase [NAD(P)H] activity
BRN52_RS17585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRN52_RS17600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRN52_RS17610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRN52_RS17615	COG0174	glutamine synthetase
BRN52_RS17620	COG3328	transposase activity
BRN52_RS17660	COG0326	Molecular chaperone. Has ATPase activity
BRN52_RS17665	COG2207	Transcriptional regulator
BRN52_RS17685	COG2755	lipolytic protein G-D-S-L family
BRN52_RS17685	COG0657	acetylesterase activity
BRN52_RS17710	COG0488	(ABC) transporter
BRN52_RS17755	COG4651	solute:proton antiporter activity
BRN52_RS17755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRN52_RS17770	COG4772	TonB-dependent receptor
BRN52_RS17780	COG4264	IucA IucC family
BRN52_RS17785	COG2814	Major facilitator Superfamily
BRN52_RS17795	COG0019	diaminopimelate decarboxylase activity
BRN52_RS17855	COG4206	TonB-dependent receptor
BRN52_RS17895	COG0542	response to heat
BRN52_RS17945	COG0534	Mate efflux family protein
BRN52_RS17960	COG0336	Belongs to the RNA methyltransferase TrmD family
BRN52_RS17965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRN52_RS17970	COG0228	four-way junction DNA binding
BRN52_RS17995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRN52_RS18010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN52_RS18060	COG1555	photosystem II stabilization
BRN52_RS18065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN52_RS18080	COG3178	'Phosphotransferase
BRN52_RS18085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRN52_RS18095	COG0628	permease
BRN52_RS18105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRN52_RS18120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRN52_RS18140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRN52_RS18150	COG0271	Belongs to the BolA IbaG family
BRN52_RS18160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRN52_RS18170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRN52_RS18175	COG1137	ATPase activity
BRN52_RS18190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN52_RS18195	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRN52_RS18200	COG1660	Displays ATPase and GTPase activities
BRN52_RS18210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN52_RS18215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN52_RS18225	COG2239	Acts as a magnesium transporter
BRN52_RS18235	COG1294	oxidase, subunit
BRN52_RS18240	COG1271	oxidase subunit
BRN52_RS18260	COG1113	amino acid transport
BRN52_RS18275	COG2197	response regulator
BRN52_RS18280	COG0531	amino acid
BRN52_RS18350	COG0754	glutathionylspermidine amidase activity
BRN52_RS18375	COG1842	Phage shock protein A
BRN52_RS18390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRN52_RS18395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BRN52_RS18405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BRN52_RS18440	COG2201	protein-glutamate methylesterase activity
BRN52_RS18490	COG2201	protein-glutamate methylesterase activity
BRN52_RS18520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BRN52_RS18565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRN52_RS18570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRN52_RS18595	COG3039	Transposase
BRN52_RS18615	COG0745	RESPONSE REGULATOR receiver
BRN52_RS18620	COG2205	protein histidine kinase activity
BRN52_RS18640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRN52_RS18685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN52_RS18685	COG3453	Protein conserved in bacteria
BRN52_RS18690	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRN52_RS18695	COG4149	molybdate abc transporter
BRN52_RS18700	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRN52_RS18720	COG0642	Histidine kinase
BRN52_RS18735	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS18745	COG1022	Amp-dependent synthetase and ligase
BRN52_RS18770	COG1376	ErfK ybiS ycfS ynhG family protein
BRN52_RS18775	COG0739	heme binding
BRN52_RS18785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRN52_RS18790	COG1301	dicarboxylic acid transport
BRN52_RS18810	COG2304	oxidoreductase activity
BRN52_RS18830	COG0714	Associated with various cellular activities
BRN52_RS18880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRN52_RS18910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRN52_RS18920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN52_RS18945	COG1561	YicC-like family, N-terminal region
BRN52_RS18950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRN52_RS18965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRN52_RS18995	COG0006	proline dipeptidase activity
BRN52_RS19020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRN52_RS19030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BRN52_RS19040	COG2912	Transglutaminase-like superfamily
BRN52_RS19045	COG1773	rubredoxin
BRN52_RS19050	COG0352	thiamine-phosphate diphosphorylase activity
BRN52_RS19085	COG0281	malic enzyme
BRN52_RS19085	COG0280	phosphate acetyltransferase
BRN52_RS19105	COG4191	Histidine kinase
BRN52_RS19120	COG0583	DNA-binding transcription factor activity
BRN52_RS19145	COG2197	response regulator
BRN52_RS19155	COG0642	Histidine kinase
BRN52_RS19175	COG2851	Citrate transporter
BRN52_RS19180	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS19185	COG1609	Transcriptional regulator
BRN52_RS19245	COG0726	polysaccharide deacetylase
BRN52_RS19250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN52_RS19300	COG0242	peptide deformylase activity
BRN52_RS19320	COG0714	Associated with various cellular activities
BRN52_RS19340	COG0537	adenosine 5'-monophosphoramidase activity
BRN52_RS19370	COG0314	molybdopterin synthase activity
BRN52_RS19375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRN52_RS19380	COG0315	cyclic pyranopterin monophosphate synthase activity
BRN52_RS19390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRN52_RS19395	COG1234	tRNA 3'-trailer cleavage
BRN52_RS19400	COG3642	lipopolysaccharide core region biosynthetic process
BRN52_RS19405	COG0859	PFAM glycosyl transferase family 9
BRN52_RS19415	COG0582	viral genome integration into host DNA
BRN52_RS19505	COG0631	protein serine/threonine phosphatase activity
BRN52_RS19515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN52_RS19540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRN52_RS19580	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRN52_RS19635	COG0473	3-isopropylmalate dehydrogenase activity
BRN52_RS19660	COG4783	chaperone-mediated protein folding
BRN52_RS19675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRN52_RS19685	COG0438	transferase activity, transferring glycosyl groups
BRN52_RS19690	COG0671	phosphoesterase, PA-phosphatase related
BRN52_RS19695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRN52_RS19715	COG2833	Protein of unknown function (DUF455)
BRN52_RS19735	COG0285	dihydrofolate synthase activity
BRN52_RS19745	COG0406	alpha-ribazole phosphatase activity
BRN52_RS19780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRN52_RS19785	COG4208	sulfate ABC transporter
BRN52_RS19790	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRN52_RS19795	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRN52_RS19800	COG0156	8-amino-7-oxononanoate synthase activity
BRN52_RS19830	COG0604	alcohol dehydrogenase
BRN52_RS19835	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRN52_RS19835	COG1902	pentaerythritol trinitrate reductase activity
BRN52_RS19875	COG0584	glycerophosphoryl diester phosphodiesterase
BRN52_RS19905	COG3039	Transposase
BRN52_RS19920	COG0625	glutathione transferase activity
BRN52_RS19930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRN52_RS19935	COG1217	gtp-binding protein TYPA
BRN52_RS19955	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRN52_RS20095	COG3781	membrane
BRN52_RS20105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRN52_RS20135	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRN52_RS20155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRN52_RS20190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRN52_RS20200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRN52_RS20235	COG0066	3-isopropylmalate dehydratase activity
BRN52_RS20240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRN52_RS20270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRN52_RS20275	COG1538	Outer membrane efflux protein
BRN52_RS20280	COG1519	Transferase
BRN52_RS20285	COG1560	Kdo2-lipid A biosynthetic process
BRN52_RS20335	COG0308	aminopeptidase N
BRN52_RS20340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BRN52_RS20350	COG0330	HflC and HflK could
BRN52_RS20355	COG0330	HflC and HflK could
BRN52_RS20375	COG0678	peroxiredoxin activity
BRN52_RS20460	COG3829	transcription factor binding
BRN52_RS20485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRN52_RS20490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRN52_RS20500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRN52_RS20505	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS20530	COG1399	metal-binding, possibly nucleic acid-binding protein
BRN52_RS20575	COG1518	maintenance of DNA repeat elements
BRN52_RS20580	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRN52_RS20635	COG2188	Transcriptional regulator
BRN52_RS20650	COG1450	Type ii and iii secretion system protein
BRN52_RS20665	COG3166	PFAM Fimbrial assembly family protein
BRN52_RS20670	COG3156	type II secretion system protein K
BRN52_RS20675	COG4795	General secretion pathway protein
BRN52_RS20680	COG2165	general secretion pathway protein
BRN52_RS20685	COG4970	Tfp pilus assembly protein FimT
BRN52_RS20690	COG2165	general secretion pathway protein
BRN52_RS20695	COG1459	type II secretion system
BRN52_RS20705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN52_RS20715	COG5295	Hep Hag repeat protein
BRN52_RS20725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRN52_RS20725	COG0047	phosphoribosylformylglycinamidine synthase activity
BRN52_RS20730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRN52_RS20735	COG4974	Belongs to the 'phage' integrase family
BRN52_RS20750	COG0795	lipopolysaccharide-transporting ATPase activity
BRN52_RS20760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRN52_RS20775	COG0525	valine-tRNA ligase activity
BRN52_RS20810	COG3039	Transposase
BRN52_RS20845	COG3039	Transposase
BRN52_RS20885	COG1183	phosphatidylcholine synthase activity
BRN52_RS20895	COG0442	prolyl-tRNA aminoacylation
BRN52_RS20910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN52_RS20915	COG1127	ABC transporter
BRN52_RS20920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN52_RS20920	COG3218	ABC-type transport auxiliary lipoprotein component
BRN52_RS20960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRN52_RS20965	COG0662	Cupin 2, conserved barrel domain protein
BRN52_RS20965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRN52_RS20990	COG2086	electron transfer activity
BRN52_RS21015	COG3328	transposase activity
BRN52_RS21065	COG0626	cystathionine gamma-synthase activity
BRN52_RS21095	COG0625	glutathione transferase activity
BRN52_RS21110	COG0513	Belongs to the DEAD box helicase family
BRN52_RS21120	COG0720	synthase
BRN52_RS21130	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRN52_RS21135	COG1956	GAF domain-containing protein
BRN52_RS21175	COG0339	signal peptide processing
BRN52_RS21225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN52_RS21230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_RS21290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRN52_RS21295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRN52_RS21300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRN52_RS21310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRN52_RS21320	COG0356	it plays a direct role in the translocation of protons across the membrane
BRN52_RS21340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRN52_RS21350	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRN52_RS21380	COG2011	ABC-type metal ion transport system permease component
BRN52_RS21390	COG0697	spore germination
BRN52_RS21430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRN52_RS21435	COG1187	pseudouridine synthase activity
BRN52_RS21440	COG2813	Specifically methylates the guanine in position
BRN52_RS21470	COG2205	protein histidine kinase activity
BRN52_RS21470	COG2202	Pas domain
BRN52_RS21495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_RS21545	COG0745	RESPONSE REGULATOR receiver
BRN52_RS21560	COG1404	Belongs to the peptidase S8 family
BRN52_RS21580	COG0842	Transport permease protein
BRN52_RS21585	COG1131	(ABC) transporter
BRN52_RS21590	COG0025	NhaP-type Na H and K H
BRN52_RS21605	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRN52_RS21615	COG1573	uracil-dna glycosylase
BRN52_RS21625	COG3384	dioxygenase
BRN52_RS21640	COG0667	Aldo Keto reductase
BRN52_RS21655	COG3590	peptidase
BRN52_RS21675	COG0531	amino acid
BRN52_RS21690	COG2972	Histidine kinase
BRN52_RS21755	COG2204	response regulator
BRN52_RS21770	COG1271	oxidase subunit
BRN52_RS21775	COG1294	oxidase, subunit
BRN52_RS21805	COG3039	Transposase
BRN52_RS21870	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRN52_RS21885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRN52_RS21935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRN52_RS21940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRN52_RS21945	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BRN52_RS21955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BRN52_RS21960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRN52_RS21975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRN52_RS22175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN52_RS22185	COG1560	Kdo2-lipid A biosynthetic process
BRN52_RS22235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRN52_RS22235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRN52_RS22240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRN52_RS22245	COG0242	peptide deformylase activity
BRN52_RS22250	COG1652	LysM domain
BRN52_RS22255	COG0758	DNA mediated transformation
BRN52_RS22260	COG2922	Belongs to the Smg family
BRN52_RS22275	COG1754	DNA topoisomerase type I activity
BRN52_RS22275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRN52_RS22280	COG0009	L-threonylcarbamoyladenylate synthase
BRN52_RS22295	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS22305	COG0616	signal peptide processing
BRN52_RS22310	COG0534	Mate efflux family protein
BRN52_RS22335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRN52_RS22365	COG1324	tolerance protein
BRN52_RS22385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRN52_RS22390	COG0511	ligase activity, forming carbon-carbon bonds
BRN52_RS22400	COG0439	Biotin carboxylase
BRN52_RS22460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRN52_RS22505	COG3210	domain, Protein
BRN52_RS22510	COG2831	hemolysin activation secretion protein
BRN52_RS22535	COG2453	phosphatase
BRN52_RS22535	COG0671	phosphoesterase, PA-phosphatase related
BRN52_RS22540	COG2267	carboxylic ester hydrolase activity
BRN52_RS22550	COG2267	carboxylic ester hydrolase activity
BRN52_RS22565	COG0419	ATPase involved in DNA repair
BRN52_RS22575	COG0151	Belongs to the GarS family
BRN52_RS22580	COG1136	(ABC) transporter
BRN52_RS22580	COG0577	efflux transmembrane transporter activity
BRN52_RS22590	COG1289	transmembrane transporter activity
BRN52_RS22605	COG2814	Major facilitator Superfamily
BRN52_RS22630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRN52_RS22665	COG0745	RESPONSE REGULATOR receiver
BRN52_RS22710	COG0739	heme binding
BRN52_RS22725	COG2211	Major facilitator Superfamily
BRN52_RS22730	COG0708	Exodeoxyribonuclease III
BRN52_RS22745	COG1192	Involved in chromosome partitioning
BRN52_RS22750	COG1475	DNA binding
BRN52_RS22765	COG0463	Glycosyl transferase, family 2
BRN52_RS22790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRN52_RS22815	COG4221	oxidoreductase activity
BRN52_RS22840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRN52_RS22845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN52_RS22850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BRN52_RS22860	COG3485	protocatechuate 3,4-dioxygenase
BRN52_RS22865	COG3485	protocatechuate 3,4-dioxygenase
BRN52_RS22905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN52_RS22915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN52_RS22930	COG1042	CoA-binding domain protein
BRN52_RS22930	COG0045	succinate-CoA ligase (ADP-forming) activity
BRN52_RS22930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRN52_RS22940	COG2239	Acts as a magnesium transporter
BRN52_RS22960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN52_RS22980	COG3100	YcgL domain-containing protein
BRN52_RS22985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRN52_RS22995	COG0463	Glycosyl transferase, family 2
BRN52_RS23010	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS23025	COG0156	8-amino-7-oxononanoate synthase activity
BRN52_RS23030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRN52_RS23035	COG1040	competence protein
BRN52_RS23040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRN52_RS23055	COG0628	permease
BRN52_RS23065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRN52_RS23075	COG1595	DNA-templated transcription, initiation
BRN52_RS23080	COG0753	catalase activity
BRN52_RS23125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN52_RS23130	COG0180	Tryptophanyl-tRNA synthetase
BRN52_RS23135	COG3237	CsbD-like
BRN52_RS23175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRN52_RS23190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRN52_RS23195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRN52_RS23195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRN52_RS23235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN52_RS23265	COG1566	PFAM secretion protein HlyD family protein
BRN52_RS23285	COG3039	Transposase
BRN52_RS23290	COG1199	ATP-dependent helicase activity
BRN52_RS23325	COG0583	DNA-binding transcription factor activity
BRN52_RS23375	COG0625	glutathione transferase activity
BRN52_RS23410	COG4555	ABC transporter
BRN52_RS23420	COG1476	TRANSCRIPTIONal
BRN52_RS23445	COG1131	(ABC) transporter
BRN52_RS23450	COG0842	Transport permease protein
BRN52_RS23460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRN52_RS23555	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN52_RS23570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRN52_RS23580	COG0564	pseudouridine synthase activity
BRN52_RS23610	COG0339	signal peptide processing
BRN52_RS23640	COG3254	rhamnose metabolic process
BRN52_RS23645	COG0738	Major facilitator superfamily
BRN52_RS23650	COG1414	Transcriptional regulator
BRN52_RS23665	COG2205	protein histidine kinase activity
BRN52_RS23680	COG3459	Glycosyltransferase 36 associated
BRN52_RS23685	COG2211	Major facilitator Superfamily
BRN52_RS23690	COG3265	gluconokinase activity
BRN52_RS23700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_RS23745	COG3039	Transposase
BRN52_RS23815	COG1127	ABC transporter
BRN52_RS23820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN52_RS23825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN52_RS23840	COG2853	Lipoprotein
BRN52_RS23865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRN52_RS23930	COG0676	glucose-6-phosphate 1-epimerase activity
BRN52_RS23955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_RS23965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_RS23975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_RS23985	COG1064	alcohol dehydrogenase
BRN52_RS24045	COG1522	sequence-specific DNA binding
BRN52_RS24050	COG3186	Phenylalanine-4-hydroxylase
BRN52_RS24065	COG2755	lipolytic protein G-D-S-L family
BRN52_RS24090	COG0656	L-ascorbic acid biosynthetic process
BRN52_RS24095	COG2130	NADP-dependent
BRN52_RS24100	COG0667	Aldo Keto reductase
BRN52_RS24110	COG1187	pseudouridine synthase activity
BRN52_RS24125	COG1643	Atp-dependent helicase
BRN52_RS24130	COG4807	Protein conserved in bacteria
BRN52_RS24135	COG4948	Mandelate Racemase Muconate Lactonizing
BRN52_RS24145	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRN52_RS24150	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_RS24170	COG3507	Belongs to the glycosyl hydrolase 43 family
BRN52_RS24215	COG3162	membrane
BRN52_RS24220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRN52_RS24235	COG0708	Exodeoxyribonuclease III
BRN52_RS24250	COG2091	lysine biosynthetic process via aminoadipic acid
BRN52_RS24260	COG3540	Alkaline phosphatase
BRN52_RS24290	COG2159	amidohydrolase
BRN52_RS24305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRN52_RS24310	COG0583	DNA-binding transcription factor activity
BRN52_RS24315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN52_RS24335	COG0210	DNA helicase
BRN52_RS24350	COG0531	amino acid
BRN52_RS24360	COG1322	Protein conserved in bacteria
BRN52_RS24370	COG0386	Belongs to the glutathione peroxidase family
BRN52_RS24420	COG0793	Belongs to the peptidase S41A family
BRN52_RS24425	COG4942	peptidase
BRN52_RS24435	COG2234	aminopeptidase activity
BRN52_RS24480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN52_RS24485	COG0302	gtp cyclohydrolase
BRN52_RS24505	COG0477	Major facilitator Superfamily
BRN52_RS24620	COG1929	Belongs to the glycerate kinase type-1 family
BRN52_RS24625	COG2271	Major facilitator Superfamily
BRN52_RS24640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRN52_RS24650	COG0861	Integral membrane protein TerC family
BRN52_RS24660	COG0584	glycerophosphoryl diester phosphodiesterase
BRN52_RS24670	COG0671	phosphoesterase, PA-phosphatase related
BRN52_RS24680	COG0726	polysaccharide deacetylase