locus-tag	class	description
APZ20_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APZ20_RS00020	COG0187	DNA topoisomerase II activity
APZ20_RS00030	COG0501	Belongs to the peptidase M48B family
APZ20_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APZ20_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ20_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APZ20_RS00090	COG4772	TonB-dependent receptor
APZ20_RS00100	COG3039	Transposase
APZ20_RS00105	COG1304	FMN binding
APZ20_RS00110	COG1755	Isoprenylcysteine carboxyl methyltransferase
APZ20_RS00125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APZ20_RS00130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ20_RS00160	COG3039	Transposase
APZ20_RS00230	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS00260	COG1090	epimerase
APZ20_RS00265	COG0642	Histidine kinase
APZ20_RS00275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APZ20_RS00380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APZ20_RS00470	COG1511	domain protein
APZ20_RS00470	COG3264	Mechanosensitive ion channel
APZ20_RS00480	COG3293	Transposase
APZ20_RS00490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APZ20_RS00495	COG2354	Protein conserved in bacteria
APZ20_RS00500	COG1649	PFAM Uncharacterised BCR, COG1649
APZ20_RS00520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APZ20_RS00545	COG0702	epimerase
APZ20_RS00555	COG1858	cytochrome C peroxidase
APZ20_RS00620	COG0513	Belongs to the DEAD box helicase family
APZ20_RS00630	COG3039	Transposase
APZ20_RS00650	COG0508	dehydrogenase complex catalyzes the overall conversion of
APZ20_RS00670	COG1136	(ABC) transporter
APZ20_RS00695	COG1136	(ABC) transporter
APZ20_RS00710	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS00735	COG1272	protein, Hemolysin III
APZ20_RS00740	COG1111	helicase
APZ20_RS00740	COG1205	dead DEAH box helicase
APZ20_RS00795	COG0067	glutamate synthase
APZ20_RS00795	COG0069	glutamate synthase activity
APZ20_RS00795	COG0070	glutamate synthase
APZ20_RS00800	COG0493	'glutamate synthase
APZ20_RS00820	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS00845	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
APZ20_RS00850	COG1609	Transcriptional regulator
APZ20_RS00875	COG0366	Alpha amylase catalytic
APZ20_RS00880	COG0366	Alpha amylase catalytic
APZ20_RS00900	COG3328	transposase activity
APZ20_RS00930	COG0606	chelatase, subunit chli
APZ20_RS00970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APZ20_RS00975	COG1166	arginine decarboxylase activity
APZ20_RS01020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APZ20_RS01045	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS01060	COG2801	Transposase and inactivated derivatives
APZ20_RS01070	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APZ20_RS01085	COG0210	DNA helicase
APZ20_RS01100	COG3132	Protein of unknown function, DUF480
APZ20_RS01105	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APZ20_RS01110	COG0284	orotidine-5'-phosphate decarboxylase activity
APZ20_RS01140	COG2937	Belongs to the GPAT DAPAT family
APZ20_RS01145	COG0604	alcohol dehydrogenase
APZ20_RS01145	COG3321	synthase
APZ20_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS01160	COG2963	transposase activity
APZ20_RS01165	COG3328	transposase activity
APZ20_RS01205	COG3328	transposase activity
APZ20_RS01215	COG1752	Esterase of the alpha-beta hydrolase superfamily
APZ20_RS01225	COG1119	ATPase activity
APZ20_RS01240	COG0517	IMP dehydrogenase activity
APZ20_RS01240	COG1125	glycine betaine transport
APZ20_RS01255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_RS01260	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APZ20_RS01265	COG3550	peptidyl-serine autophosphorylation
APZ20_RS01270	COG1396	sequence-specific DNA binding
APZ20_RS01290	COG0489	protein tyrosine kinase activity
APZ20_RS01295	COG2062	phosphohistidine phosphatase, SixA
APZ20_RS01305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ20_RS01350	COG1968	undecaprenyl-diphosphatase activity
APZ20_RS01355	COG0174	glutamine synthetase
APZ20_RS01360	COG0347	Belongs to the P(II) protein family
APZ20_RS01365	COG0004	ammonium transporteR
APZ20_RS01370	COG3852	Histidine kinase
APZ20_RS01375	COG2204	response regulator
APZ20_RS01380	COG2032	superoxide dismutase activity
APZ20_RS01385	COG2032	superoxide dismutase activity
APZ20_RS01420	COG1196	nuclear chromosome segregation
APZ20_RS01445	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APZ20_RS01450	COG1074	ATP-dependent DNA helicase activity
APZ20_RS01460	COG3549	Plasmid maintenance system killer
APZ20_RS01535	COG1764	response to oxidative stress
APZ20_RS01540	COG1846	Transcriptional regulator
APZ20_RS01590	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APZ20_RS01600	COG3293	Transposase
APZ20_RS01630	COG2211	Major facilitator Superfamily
APZ20_RS01650	COG3693	PFAM glycoside hydrolase, family 10
APZ20_RS01655	COG3693	PFAM glycoside hydrolase, family 10
APZ20_RS01680	COG0246	Mannitol dehydrogenase
APZ20_RS01685	COG1472	Belongs to the glycosyl hydrolase 3 family
APZ20_RS01695	COG4948	Mandelate Racemase Muconate Lactonizing
APZ20_RS01705	COG3661	Belongs to the glycosyl hydrolase 67 family
APZ20_RS01720	COG0037	tRNA processing
APZ20_RS01725	COG2974	May be involved in recombination
APZ20_RS01750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APZ20_RS01760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APZ20_RS01770	COG0805	protein transport
APZ20_RS01780	COG0519	Catalyzes the synthesis of GMP from XMP
APZ20_RS01780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APZ20_RS01795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ20_RS01800	COG0752	glycyl-tRNA synthetase alpha subunit
APZ20_RS01810	COG0457	Tetratricopeptide repeat
APZ20_RS01815	COG4771	TonB-dependent receptor
APZ20_RS01830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APZ20_RS01840	COG0697	spore germination
APZ20_RS01850	COG0523	cobalamin synthesis protein
APZ20_RS01910	COG1960	acyl-CoA dehydrogenase activity
APZ20_RS01915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APZ20_RS01920	COG4770	biotin carboxylase activity
APZ20_RS01930	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS01965	COG2351	hydroxyisourate hydrolase activity
APZ20_RS01985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APZ20_RS02030	COG0084	hydrolase, TatD family'
APZ20_RS02045	COG0583	DNA-binding transcription factor activity
APZ20_RS02050	COG2814	Major facilitator Superfamily
APZ20_RS02060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APZ20_RS02065	COG1902	pentaerythritol trinitrate reductase activity
APZ20_RS02095	COG0745	RESPONSE REGULATOR receiver
APZ20_RS02100	COG2205	protein histidine kinase activity
APZ20_RS02105	COG2205	protein histidine kinase activity
APZ20_RS02120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APZ20_RS02125	COG0583	DNA-binding transcription factor activity
APZ20_RS02155	COG0702	epimerase
APZ20_RS02160	COG1733	regulation of RNA biosynthetic process
APZ20_RS02225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APZ20_RS02240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APZ20_RS02280	COG2911	Protein conserved in bacteria
APZ20_RS02285	COG0729	surface antigen
APZ20_RS02295	COG2963	transposase activity
APZ20_RS02305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APZ20_RS02310	COG3118	belongs to the thioredoxin family
APZ20_RS02320	COG2884	Cell division ATP-binding protein ftsE
APZ20_RS02325	COG2177	Part of the ABC transporter FtsEX involved in
APZ20_RS02330	COG2201	protein-glutamate methylesterase activity
APZ20_RS02335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APZ20_RS02340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APZ20_RS02350	COG1252	NADH dehydrogenase
APZ20_RS02380	COG0459	protein refolding
APZ20_RS02390	COG4771	TonB-dependent receptor
APZ20_RS02405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APZ20_RS02445	COG3386	PFAM SMP-30 Gluconolaconase
APZ20_RS02460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APZ20_RS02495	COG2353	YceI-like domain
APZ20_RS02585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APZ20_RS02630	COG0408	coproporphyrinogen oxidase activity
APZ20_RS02645	COG3039	Transposase
APZ20_RS02665	COG0129	dihydroxy-acid dehydratase activity
APZ20_RS02675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APZ20_RS02700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APZ20_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
APZ20_RS02710	COG0727	PFAM Uncharacterised protein family (UPF0153)
APZ20_RS02715	COG0596	Alpha beta hydrolase
APZ20_RS02730	COG3177	Filamentation induced by cAMP protein fic
APZ20_RS02735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APZ20_RS02750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APZ20_RS02775	COG4191	Histidine kinase
APZ20_RS02780	COG0028	Belongs to the TPP enzyme family
APZ20_RS02795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APZ20_RS02800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APZ20_RS02825	COG5383	Protein conserved in bacteria
APZ20_RS02835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_RS02840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_RS02845	COG1473	amidohydrolase
APZ20_RS02855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APZ20_RS02855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APZ20_RS02860	COG3328	transposase activity
APZ20_RS02960	COG0358	DNA primase activity
APZ20_RS02965	COG1295	ribonuclease BN
APZ20_RS02975	COG3293	Transposase
APZ20_RS02985	COG1610	YqeY-like protein
APZ20_RS02995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APZ20_RS03000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APZ20_RS03010	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS03030	COG3293	Transposase
APZ20_RS03060	COG2133	pyrroloquinoline quinone binding
APZ20_RS03070	COG4682	membrane
APZ20_RS03090	COG3293	Transposase
APZ20_RS03100	COG0531	amino acid
APZ20_RS03130	COG4948	Mandelate Racemase Muconate Lactonizing
APZ20_RS03140	COG3023	N-Acetylmuramoyl-L-alanine amidase
APZ20_RS03145	COG3039	Transposase
APZ20_RS03155	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APZ20_RS03190	COG3039	Transposase
APZ20_RS03240	COG0183	Belongs to the thiolase family
APZ20_RS03255	COG0022	dehydrogenase e1 component
APZ20_RS03270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APZ20_RS03275	COG3483	tryptophan 2,3-dioxygenase activity
APZ20_RS03280	COG3104	oligopeptide transport
APZ20_RS03305	COG1320	monovalent cation:proton antiporter activity
APZ20_RS03310	COG2212	antiporter activity
APZ20_RS03320	COG0651	ATP synthesis coupled electron transport
APZ20_RS03325	COG1006	Multisubunit Na H antiporter MnhC subunit
APZ20_RS03330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APZ20_RS03330	COG2111	Na H antiporter
APZ20_RS03345	COG3227	Zinc metalloprotease (Elastase)
APZ20_RS03375	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APZ20_RS03385	COG0456	acetyltransferase
APZ20_RS03405	COG2963	transposase activity
APZ20_RS03420	COG4221	oxidoreductase activity
APZ20_RS03490	COG0697	spore germination
APZ20_RS03495	COG4305	rare lipoprotein A
APZ20_RS03500	COG5297	Belongs to the glycosyl hydrolase family 6
APZ20_RS03505	COG1113	amino acid transport
APZ20_RS03515	COG0598	Magnesium transport protein CorA
APZ20_RS03555	COG3293	Transposase
APZ20_RS03590	COG0840	transmembrane signaling receptor activity
APZ20_RS03600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_RS03600	COG5297	Belongs to the glycosyl hydrolase family 6
APZ20_RS03605	COG0659	secondary active sulfate transmembrane transporter activity
APZ20_RS03635	COG3293	Transposase
APZ20_RS03655	COG3275	phosphorelay sensor kinase activity
APZ20_RS03665	COG0181	hydroxymethylbilane synthase activity
APZ20_RS03690	COG1505	serine-type exopeptidase activity
APZ20_RS03705	COG0436	Aminotransferase
APZ20_RS03735	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APZ20_RS03765	COG0308	aminopeptidase N
APZ20_RS03770	COG2199	diguanylate cyclase activity
APZ20_RS03825	COG3039	Transposase
APZ20_RS03830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ20_RS03835	COG1077	Cell shape determining protein MreB Mrl
APZ20_RS03840	COG1792	Involved in formation and maintenance of cell shape
APZ20_RS03855	COG0772	Belongs to the SEDS family
APZ20_RS03910	COG2951	lytic endotransglycosylase activity
APZ20_RS03915	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APZ20_RS03925	COG1686	Belongs to the peptidase S11 family
APZ20_RS03935	COG2921	Belongs to the UPF0250 family
APZ20_RS03960	COG1051	belongs to the nudix hydrolase family
APZ20_RS03960	COG1056	cytidyltransferase-related domain
APZ20_RS04000	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APZ20_RS04005	COG0673	inositol 2-dehydrogenase activity
APZ20_RS04010	COG2823	Periplasmic or secreted lipoprotein
APZ20_RS04015	COG4251	negative regulation of phosphorylation
APZ20_RS04020	COG0784	Response regulator, receiver
APZ20_RS04025	COG4191	Histidine kinase
APZ20_RS04030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APZ20_RS04050	COG2801	Transposase and inactivated derivatives
APZ20_RS04060	COG2963	transposase activity
APZ20_RS04085	COG2188	Transcriptional regulator
APZ20_RS04095	COG1609	Transcriptional regulator
APZ20_RS04100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APZ20_RS04105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APZ20_RS04115	COG1215	transferase activity, transferring glycosyl groups
APZ20_RS04120	COG0726	polysaccharide deacetylase
APZ20_RS04120	COG1649	PFAM Uncharacterised BCR, COG1649
APZ20_RS04150	COG3293	Transposase
APZ20_RS04205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APZ20_RS04210	COG3039	Transposase
APZ20_RS04215	COG2963	transposase activity
APZ20_RS04225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ20_RS04250	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APZ20_RS04295	COG2205	protein histidine kinase activity
APZ20_RS04325	COG3791	Glutathione-dependent formaldehyde-activating
APZ20_RS04350	COG0488	(ABC) transporter
APZ20_RS04370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APZ20_RS04390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APZ20_RS04390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APZ20_RS04410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APZ20_RS04415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APZ20_RS04420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APZ20_RS04445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APZ20_RS04450	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APZ20_RS04460	COG2205	protein histidine kinase activity
APZ20_RS04465	COG0745	RESPONSE REGULATOR receiver
APZ20_RS04470	COG0277	FAD linked oxidase domain protein
APZ20_RS04475	COG1988	membrane-bound metal-dependent
APZ20_RS04480	COG0792	nuclease activity
APZ20_RS04515	COG0275	rRNA processing
APZ20_RS04520	COG3116	cell division
APZ20_RS04535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APZ20_RS04555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APZ20_RS04560	COG1181	Belongs to the D-alanine--D-alanine ligase family
APZ20_RS04565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APZ20_RS04580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APZ20_RS04590	COG4942	peptidase
APZ20_RS04590	COG1388	LysM domain
APZ20_RS04605	COG0494	nUDIX hydrolase
APZ20_RS04625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APZ20_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS04635	COG0604	alcohol dehydrogenase
APZ20_RS04635	COG3321	synthase
APZ20_RS04690	COG2226	methyltransferase
APZ20_RS04695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APZ20_RS04730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APZ20_RS04740	COG4106	trans-aconitate 2-methyltransferase activity
APZ20_RS04745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APZ20_RS04760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ20_RS04765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APZ20_RS04775	COG0667	Aldo Keto reductase
APZ20_RS04790	COG3293	Transposase
APZ20_RS04830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APZ20_RS04840	COG2175	clavaminate synthase activity
APZ20_RS04850	COG4181	ATPase activity
APZ20_RS04865	COG0642	Histidine kinase
APZ20_RS04880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APZ20_RS04900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APZ20_RS04925	COG2967	ApaG domain
APZ20_RS04930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APZ20_RS04940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APZ20_RS04955	COG0123	including yeast histone deacetylase and acetoin utilization protein
APZ20_RS04960	COG2096	Adenosyltransferase
APZ20_RS04970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APZ20_RS04975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APZ20_RS05015	COG0583	DNA-binding transcription factor activity
APZ20_RS05020	COG0318	PFAM AMP-dependent synthetase and ligase
APZ20_RS05030	COG1024	Enoyl-CoA hydratase
APZ20_RS05050	COG3386	PFAM SMP-30 Gluconolaconase
APZ20_RS05100	COG3293	Transposase
APZ20_RS05110	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS05165	COG2197	response regulator
APZ20_RS05205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APZ20_RS05210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ20_RS05215	COG0583	DNA-binding transcription factor activity
APZ20_RS05220	COG3634	alkyl hydroperoxide reductase activity
APZ20_RS05230	COG2890	protein-(glutamine-N5) methyltransferase activity
APZ20_RS05270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APZ20_RS05270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APZ20_RS05285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APZ20_RS05310	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APZ20_RS05335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APZ20_RS05345	COG1404	Belongs to the peptidase S8 family
APZ20_RS05350	COG1404	Belongs to the peptidase S8 family
APZ20_RS05355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APZ20_RS05385	COG1295	ribonuclease BN
APZ20_RS05390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APZ20_RS05410	COG0521	Mo-molybdopterin cofactor biosynthetic process
APZ20_RS05420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APZ20_RS05435	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
APZ20_RS05450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APZ20_RS05460	COG0193	aminoacyl-tRNA hydrolase activity
APZ20_RS05465	COG0012	GTP binding
APZ20_RS05495	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APZ20_RS05500	COG0250	Participates in transcription elongation, termination and antitermination
APZ20_RS05505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APZ20_RS05515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APZ20_RS05520	COG0222	ribosome binding
APZ20_RS05525	COG0085	RNA polymerase activity
APZ20_RS05530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APZ20_RS05535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APZ20_RS05540	COG0049	tRNA binding
APZ20_RS05555	COG0051	transcription antitermination factor activity, RNA binding
APZ20_RS05560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APZ20_RS05565	COG0088	Forms part of the polypeptide exit tunnel
APZ20_RS05570	COG0089	rRNA binding
APZ20_RS05595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APZ20_RS05600	COG0255	Belongs to the universal ribosomal protein uL29 family
APZ20_RS05605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APZ20_RS05610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APZ20_RS05615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APZ20_RS05620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APZ20_RS05640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APZ20_RS05650	COG1841	ribosomal large subunit assembly
APZ20_RS05660	COG0201	protein transport
APZ20_RS05670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APZ20_RS05675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APZ20_RS05685	COG0203	ribosomal protein L17
APZ20_RS05710	COG2963	transposase activity
APZ20_RS05755	COG3551	Protein conserved in bacteria
APZ20_RS05785	COG2194	sulfuric ester hydrolase activity
APZ20_RS05795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APZ20_RS05800	COG0745	RESPONSE REGULATOR receiver
APZ20_RS05805	COG0642	Histidine kinase
APZ20_RS05815	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APZ20_RS05820	COG2894	cell division
APZ20_RS05845	COG4585	Histidine kinase
APZ20_RS05850	COG2197	response regulator
APZ20_RS05865	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APZ20_RS05895	COG2963	transposase activity
APZ20_RS05955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_RS05965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_RS06020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_RS06085	COG2801	Transposase and inactivated derivatives
APZ20_RS06090	COG2963	transposase activity
APZ20_RS06265	COG0732	type I restriction modification DNA specificity domain
APZ20_RS06280	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APZ20_RS06300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APZ20_RS06305	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
APZ20_RS06310	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
APZ20_RS06315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APZ20_RS06400	COG0587	DNA-directed DNA polymerase activity
APZ20_RS06415	COG1297	OPT oligopeptide transporter protein
APZ20_RS06440	COG1506	peptidase
APZ20_RS06440	COG0823	Involved in the tonB-independent uptake of proteins
APZ20_RS06465	COG2207	Transcriptional regulator
APZ20_RS06465	COG1917	Cupin 2, conserved barrel domain protein
APZ20_RS06490	COG0753	catalase activity
APZ20_RS06505	COG3039	Transposase
APZ20_RS06530	COG0126	phosphoglycerate kinase activity
APZ20_RS06540	COG0469	pyruvate kinase activity
APZ20_RS06545	COG3588	fructose-bisphosphate aldolase
APZ20_RS06550	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APZ20_RS06600	COG2198	Histidine kinase
APZ20_RS06600	COG2205	protein histidine kinase activity
APZ20_RS06600	COG0784	Response regulator, receiver
APZ20_RS06620	COG0175	sulfate reduction
APZ20_RS06625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APZ20_RS06630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APZ20_RS06635	COG0175	sulfate reduction
APZ20_RS06640	COG2895	sulfate adenylyltransferase (ATP) activity
APZ20_RS06640	COG0529	Catalyzes the synthesis of activated sulfate
APZ20_RS06650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_RS06655	COG0308	aminopeptidase N
APZ20_RS06685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APZ20_RS06690	COG2272	Belongs to the type-B carboxylesterase lipase family
APZ20_RS06730	COG1970	mechanosensitive ion channel activity
APZ20_RS06740	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS06775	COG3273	potassium ion transport
APZ20_RS06775	COG0471	metal ion transport
APZ20_RS06785	COG2022	thiamine diphosphate biosynthetic process
APZ20_RS06820	COG2963	transposase activity
APZ20_RS06850	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS06855	COG3293	Transposase
APZ20_RS06880	COG3039	Transposase
APZ20_RS06895	COG3293	Transposase
APZ20_RS06905	COG3039	Transposase
APZ20_RS06950	COG3293	Transposase
APZ20_RS06965	COG3118	belongs to the thioredoxin family
APZ20_RS06990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APZ20_RS07015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APZ20_RS07045	COG3039	Transposase
APZ20_RS07055	COG2968	Membrane
APZ20_RS07070	COG3164	Protein of unknown function
APZ20_RS07080	COG0312	modulator of DNA gyrase
APZ20_RS07090	COG0312	modulator of DNA gyrase
APZ20_RS07110	COG0142	geranyltranstransferase activity
APZ20_RS07115	COG1722	exodeoxyribonuclease VII activity
APZ20_RS07120	COG0037	tRNA processing
APZ20_RS07125	COG1785	Belongs to the alkaline phosphatase family
APZ20_RS07130	COG1301	dicarboxylic acid transport
APZ20_RS07145	COG0791	NLP P60 protein
APZ20_RS07150	COG0791	NLP P60 protein
APZ20_RS07155	COG1047	Peptidyl-prolyl cis-trans
APZ20_RS07160	COG2311	Membrane
APZ20_RS07165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_RS07200	COG0489	protein tyrosine kinase activity
APZ20_RS07205	COG0717	Belongs to the dCTP deaminase family
APZ20_RS07220	COG0412	Dienelactone hydrolase
APZ20_RS07230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ20_RS07250	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS07255	COG0433	COG0433 Predicted ATPase
APZ20_RS07280	COG2890	protein-(glutamine-N5) methyltransferase activity
APZ20_RS07285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APZ20_RS07290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APZ20_RS07295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APZ20_RS07315	COG0101	tRNA pseudouridine synthase activity
APZ20_RS07320	COG0135	phosphoribosylanthranilate isomerase activity
APZ20_RS07330	COG0133	tryptophan synthase activity
APZ20_RS07345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APZ20_RS07350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APZ20_RS07375	COG3293	Transposase
APZ20_RS07400	COG0149	triose-phosphate isomerase activity
APZ20_RS07415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APZ20_RS07425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APZ20_RS07430	COG0649	NAD binding
APZ20_RS07435	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APZ20_RS07440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APZ20_RS07445	COG1034	ATP synthesis coupled electron transport
APZ20_RS07450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APZ20_RS07480	COG1007	ATP synthesis coupled electron transport
APZ20_RS07490	COG0779	Required for maturation of 30S ribosomal subunits
APZ20_RS07495	COG0195	Participates in both transcription termination and antitermination
APZ20_RS07515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APZ20_RS07520	COG1185	polyribonucleotide nucleotidyltransferase activity
APZ20_RS07555	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APZ20_RS07565	COG2095	MarC family integral membrane protein
APZ20_RS07580	COG1611	Belongs to the LOG family
APZ20_RS07585	COG3039	Transposase
APZ20_RS07625	COG4969	Belongs to the N-Me-Phe pilin family
APZ20_RS07630	COG0556	nucleotide-excision repair
APZ20_RS07655	COG2963	transposase activity
APZ20_RS07670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APZ20_RS07680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APZ20_RS07685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APZ20_RS07740	COG0438	transferase activity, transferring glycosyl groups
APZ20_RS07745	COG0438	transferase activity, transferring glycosyl groups
APZ20_RS07755	COG0438	transferase activity, transferring glycosyl groups
APZ20_RS07875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APZ20_RS07890	COG0784	Response regulator, receiver
APZ20_RS07890	COG4191	Histidine kinase
APZ20_RS07900	COG0784	Response regulator, receiver
APZ20_RS07900	COG4191	Histidine kinase
APZ20_RS07925	COG0552	protein localization to endoplasmic reticulum
APZ20_RS07935	COG3938	Belongs to the proline racemase family
APZ20_RS07940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_RS07955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APZ20_RS07965	COG0006	proline dipeptidase activity
APZ20_RS07980	COG0531	amino acid
APZ20_RS08030	COG4206	TonB-dependent receptor
APZ20_RS08055	COG4206	TonB-dependent receptor
APZ20_RS08060	COG3328	transposase activity
APZ20_RS08110	COG0746	molybdenum cofactor guanylyltransferase activity
APZ20_RS08135	COG1648	precorrin-2 dehydrogenase activity
APZ20_RS08135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APZ20_RS08205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APZ20_RS08225	COG1054	Belongs to the UPF0176 family
APZ20_RS08235	COG3293	Transposase
APZ20_RS08250	COG1530	ribonuclease E activity
APZ20_RS08260	COG3064	Membrane
APZ20_RS08265	COG0428	transporter
APZ20_RS08270	COG0428	transporter
APZ20_RS08295	COG2801	Transposase and inactivated derivatives
APZ20_RS08350	COG3039	Transposase
APZ20_RS08410	COG3039	Transposase
APZ20_RS08455	COG0631	protein serine/threonine phosphatase activity
APZ20_RS08460	COG0515	serine threonine protein kinase
APZ20_RS08490	COG1858	cytochrome C peroxidase
APZ20_RS08500	COG4644	lycopene metabolic process
APZ20_RS08515	COG2963	transposase activity
APZ20_RS08545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_RS08550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_RS08565	COG2201	protein-glutamate methylesterase activity
APZ20_RS08595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APZ20_RS08615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APZ20_RS08630	COG1595	DNA-templated transcription, initiation
APZ20_RS08680	COG2244	polysaccharide biosynthetic process
APZ20_RS08710	COG2264	protein methyltransferase activity
APZ20_RS08720	COG0438	transferase activity, transferring glycosyl groups
APZ20_RS08735	COG1136	(ABC) transporter
APZ20_RS08740	COG1132	(ABC) transporter
APZ20_RS08750	COG0477	Major facilitator Superfamily
APZ20_RS08760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APZ20_RS08775	COG1253	flavin adenine dinucleotide binding
APZ20_RS08785	COG0306	phosphate transporter
APZ20_RS08815	COG0504	CTP synthase activity
APZ20_RS08820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APZ20_RS08830	COG0148	phosphopyruvate hydratase activity
APZ20_RS08835	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APZ20_RS08840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APZ20_RS08850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APZ20_RS08860	COG2840	Smr protein MutS2
APZ20_RS08865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APZ20_RS08870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APZ20_RS08875	COG1238	metal cluster binding
APZ20_RS08890	COG1534	Rna-binding protein
APZ20_RS08895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APZ20_RS08905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APZ20_RS08920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APZ20_RS08925	COG1546	Belongs to the CinA family
APZ20_RS08940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APZ20_RS08945	COG2137	regulation of response to DNA damage stimulus
APZ20_RS08950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APZ20_RS08955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APZ20_RS08975	COG0305	Participates in initiation and elongation during chromosome replication
APZ20_RS08980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APZ20_RS09000	COG1741	Belongs to the pirin family
APZ20_RS09005	COG0583	DNA-binding transcription factor activity
APZ20_RS09035	COG0351	phosphomethylpyrimidine kinase
APZ20_RS09045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APZ20_RS09050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APZ20_RS09065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APZ20_RS09075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APZ20_RS09080	COG3734	2-keto-3-deoxy-galactonokinase
APZ20_RS09090	COG4948	Mandelate Racemase Muconate Lactonizing
APZ20_RS09095	COG0800	Aldolase
APZ20_RS09110	COG1501	Belongs to the glycosyl hydrolase 31 family
APZ20_RS09125	COG1070	Carbohydrate kinase
APZ20_RS09135	COG0477	Major facilitator Superfamily
APZ20_RS09155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APZ20_RS09205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APZ20_RS09210	COG2258	MOSC domain
APZ20_RS09215	COG3293	Transposase
APZ20_RS09225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APZ20_RS09230	COG0505	Belongs to the CarA family
APZ20_RS09240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APZ20_RS09245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ20_RS09255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APZ20_RS09295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APZ20_RS09315	COG0784	Response regulator, receiver
APZ20_RS09315	COG2198	Histidine kinase
APZ20_RS09315	COG2205	protein histidine kinase activity
APZ20_RS09320	COG1024	Enoyl-CoA hydratase
APZ20_RS09325	COG0318	PFAM AMP-dependent synthetase and ligase
APZ20_RS09355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APZ20_RS09385	COG0840	transmembrane signaling receptor activity
APZ20_RS09405	COG0835	chemotaxis
APZ20_RS09420	COG0840	transmembrane signaling receptor activity
APZ20_RS09425	COG0840	transmembrane signaling receptor activity
APZ20_RS09430	COG0840	transmembrane signaling receptor activity
APZ20_RS09435	COG0840	transmembrane signaling receptor activity
APZ20_RS09445	COG0840	transmembrane signaling receptor activity
APZ20_RS09455	COG3293	Transposase
APZ20_RS09465	COG0840	transmembrane signaling receptor activity
APZ20_RS09495	COG0745	RESPONSE REGULATOR receiver
APZ20_RS09505	COG0835	chemotaxis
APZ20_RS09515	COG1360	Flagellar Motor Protein
APZ20_RS09520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APZ20_RS09540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APZ20_RS09550	COG4771	TonB-dependent receptor
APZ20_RS09675	COG3039	Transposase
APZ20_RS09720	COG0343	queuine tRNA-ribosyltransferase activity
APZ20_RS09725	COG1862	Preprotein translocase
APZ20_RS09730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APZ20_RS09735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APZ20_RS09765	COG3328	transposase activity
APZ20_RS09780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APZ20_RS09790	COG0704	Plays a role in the regulation of phosphate uptake
APZ20_RS09805	COG0573	inorganic phosphate transmembrane transporter activity
APZ20_RS09810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APZ20_RS09830	COG3293	Transposase
APZ20_RS09850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APZ20_RS09860	COG1024	Enoyl-CoA hydratase
APZ20_RS09870	COG0494	nUDIX hydrolase
APZ20_RS09915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APZ20_RS09915	COG0116	Belongs to the methyltransferase superfamily
APZ20_RS09940	COG0667	Aldo Keto reductase
APZ20_RS09950	COG2925	Exonuclease
APZ20_RS09975	COG0288	reversible hydration of carbon dioxide
APZ20_RS10010	COG0316	Belongs to the HesB IscA family
APZ20_RS10015	COG0360	Binds together with S18 to 16S ribosomal RNA
APZ20_RS10025	COG0359	binds to the 23S rRNA
APZ20_RS10035	COG3115	cell septum assembly
APZ20_RS10050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APZ20_RS10065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APZ20_RS10075	COG2963	transposase activity
APZ20_RS10095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APZ20_RS10105	COG2986	histidine ammonia-lyase
APZ20_RS10110	COG1228	amidohydrolase
APZ20_RS10155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APZ20_RS10165	COG1605	Chorismate mutase
APZ20_RS10165	COG0077	Prephenate dehydratase
APZ20_RS10170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APZ20_RS10180	COG2963	transposase activity
APZ20_RS10200	COG4566	intracellular signal transduction
APZ20_RS10245	COG0860	N-Acetylmuramoyl-L-alanine amidase
APZ20_RS10250	COG1469	GTP cyclohydrolase I activity
APZ20_RS10270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APZ20_RS10305	COG1472	Belongs to the glycosyl hydrolase 3 family
APZ20_RS10320	COG5001	Diguanylate cyclase
APZ20_RS10320	COG4251	negative regulation of phosphorylation
APZ20_RS10320	COG2203	Gaf domain
APZ20_RS10320	COG3706	GGDEF domain
APZ20_RS10405	COG0386	Belongs to the glutathione peroxidase family
APZ20_RS10485	COG3293	Transposase
APZ20_RS10495	COG1247	-acetyltransferase
APZ20_RS10520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APZ20_RS10545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APZ20_RS10560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APZ20_RS10570	COG0431	NADPH-dependent FMN reductase
APZ20_RS10575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APZ20_RS10580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APZ20_RS10600	COG2205	protein histidine kinase activity
APZ20_RS10600	COG0784	Response regulator, receiver
APZ20_RS10600	COG5002	protein histidine kinase activity
APZ20_RS10625	COG3293	Transposase
APZ20_RS10640	COG0800	Aldolase
APZ20_RS10645	COG0129	dihydroxy-acid dehydratase activity
APZ20_RS10650	COG0363	glucosamine-6-phosphate deaminase activity
APZ20_RS10660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APZ20_RS10675	COG0354	folic acid binding
APZ20_RS10685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APZ20_RS10700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APZ20_RS10715	COG4591	ABC-type transport system involved in lipoprotein release permease component
APZ20_RS10740	COG0811	peptide transport
APZ20_RS10755	COG1663	tetraacyldisaccharide 4'-kinase activity
APZ20_RS10765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APZ20_RS10775	COG0322	excinuclease ABC activity
APZ20_RS10810	COG3328	transposase activity
APZ20_RS10835	COG2801	Transposase and inactivated derivatives
APZ20_RS10845	COG2201	protein-glutamate methylesterase activity
APZ20_RS10865	COG3293	Transposase
APZ20_RS10910	COG3293	Transposase
APZ20_RS10980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APZ20_RS10980	COG0140	phosphoribosyl-ATP diphosphatase activity
APZ20_RS10990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APZ20_RS11000	COG0131	Imidazoleglycerol-phosphate dehydratase
APZ20_RS11000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APZ20_RS11015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APZ20_RS11040	COG0124	histidyl-tRNA synthetase
APZ20_RS11045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ20_RS11055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APZ20_RS11090	COG1012	belongs to the aldehyde dehydrogenase family
APZ20_RS11115	COG0697	spore germination
APZ20_RS11120	COG1794	racemase activity, acting on amino acids and derivatives
APZ20_RS11140	COG0671	phosphoesterase, PA-phosphatase related
APZ20_RS11155	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
APZ20_RS11170	COG2183	response to ionizing radiation
APZ20_RS11180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_RS11180	COG0723	plastoquinol--plastocyanin reductase activity
APZ20_RS11195	COG3243	poly(R)-hydroxyalkanoic acid synthase
APZ20_RS11205	COG1183	phosphatidylcholine synthase activity
APZ20_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS11235	COG0668	transmembrane transport
APZ20_RS11255	COG1914	H( )-stimulated, divalent metal cation uptake system
APZ20_RS11270	COG0583	DNA-binding transcription factor activity
APZ20_RS11275	COG0583	DNA-binding transcription factor activity
APZ20_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS11305	COG0583	DNA-binding transcription factor activity
APZ20_RS11310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APZ20_RS11330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APZ20_RS11365	COG0475	glutathione-regulated potassium exporter activity
APZ20_RS11365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APZ20_RS11370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APZ20_RS11380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APZ20_RS11385	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APZ20_RS11395	COG0776	regulation of translation
APZ20_RS11400	COG0539	negative regulation of cytoplasmic translation
APZ20_RS11405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APZ20_RS11420	COG2957	Belongs to the agmatine deiminase family
APZ20_RS11430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APZ20_RS11455	COG0395	ABC-type sugar transport system, permease component
APZ20_RS11460	COG1175	transmembrane transport
APZ20_RS11490	COG2350	Protein conserved in bacteria
APZ20_RS11495	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APZ20_RS11500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APZ20_RS11505	COG1187	pseudouridine synthase activity
APZ20_RS11530	COG0436	Aminotransferase
APZ20_RS11590	COG0277	FAD linked oxidase domain protein
APZ20_RS11595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APZ20_RS11605	COG0531	amino acid
APZ20_RS11610	COG0531	amino acid
APZ20_RS11620	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APZ20_RS11650	COG3039	Transposase
APZ20_RS11660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APZ20_RS11695	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS11740	COG0303	'Molybdopterin
APZ20_RS11750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_RS11760	COG1426	Protein conserved in bacteria
APZ20_RS11770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APZ20_RS11785	COG1250	3-hydroxyacyl-CoA dehydrogenase
APZ20_RS11785	COG1024	Enoyl-CoA hydratase
APZ20_RS11790	COG0183	Belongs to the thiolase family
APZ20_RS11795	COG0038	chloride channel
APZ20_RS11815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APZ20_RS11835	COG1674	ftsk spoiiie
APZ20_RS11840	COG0492	ferredoxin-NADP+ reductase activity
APZ20_RS11870	COG0542	response to heat
APZ20_RS11910	COG5001	Diguanylate cyclase
APZ20_RS11915	COG4585	Histidine kinase
APZ20_RS11925	COG5002	protein histidine kinase activity
APZ20_RS11945	COG0784	Response regulator, receiver
APZ20_RS11945	COG0835	chemotaxis
APZ20_RS11955	COG1558	bacterial-type flagellum-dependent cell motility
APZ20_RS11960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APZ20_RS11970	COG4787	bacterial-type flagellum-dependent cell motility
APZ20_RS12010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ20_RS12015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APZ20_RS12045	COG2201	protein-glutamate methylesterase activity
APZ20_RS12065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APZ20_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS12110	COG1677	Flagellar hook-basal body complex protein FliE
APZ20_RS12160	COG3190	flagellar
APZ20_RS12175	COG1684	flagellar biosynthetic protein fliR
APZ20_RS12230	COG0784	Response regulator, receiver
APZ20_RS12230	COG2198	Histidine kinase
APZ20_RS12230	COG0643	Histidine kinase
APZ20_RS12245	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS12265	COG3209	COG3209 Rhs family protein
APZ20_RS12290	COG3039	Transposase
APZ20_RS12375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APZ20_RS12380	COG4988	ABC transporter
APZ20_RS12390	COG1271	oxidase subunit
APZ20_RS12395	COG1294	oxidase, subunit
APZ20_RS12420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APZ20_RS12440	COG0165	Argininosuccinate lyase
APZ20_RS12455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APZ20_RS12460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APZ20_RS12470	COG0137	argininosuccinate synthase activity
APZ20_RS12475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APZ20_RS12490	COG2166	iron-sulfur cluster assembly
APZ20_RS12520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APZ20_RS12530	COG4302	ethanolamine ammonia-lyase activity
APZ20_RS12550	COG3039	Transposase
APZ20_RS12570	COG4677	pectinesterase activity
APZ20_RS12600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APZ20_RS12605	COG0402	S-adenosylhomocysteine deaminase activity
APZ20_RS12620	COG1509	lysine 2,3-aminomutase activity
APZ20_RS12625	COG5001	Diguanylate cyclase
APZ20_RS12625	COG3300	MHYT domain
APZ20_RS12640	COG0483	inositol monophosphate 1-phosphatase activity
APZ20_RS12645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APZ20_RS12670	COG0488	(ABC) transporter
APZ20_RS12675	COG0513	Belongs to the DEAD box helicase family
APZ20_RS12685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APZ20_RS12695	COG0625	glutathione transferase activity
APZ20_RS12705	COG1671	Belongs to the UPF0178 family
APZ20_RS12710	COG4681	YaeQ
APZ20_RS12715	COG2081	HI0933 family
APZ20_RS12735	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS12755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APZ20_RS12760	COG0860	N-Acetylmuramoyl-L-alanine amidase
APZ20_RS12765	COG0802	atpase or kinase
APZ20_RS12770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APZ20_RS12770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APZ20_RS12775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APZ20_RS12795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_RS12860	COG3039	Transposase
APZ20_RS12865	COG3328	transposase activity
APZ20_RS12895	COG2969	positive regulation of protein catabolic process
APZ20_RS12900	COG0625	glutathione transferase activity
APZ20_RS12905	COG2857	Cytochrome c1
APZ20_RS12910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APZ20_RS12915	COG0723	plastoquinol--plastocyanin reductase activity
APZ20_RS12920	COG0741	lytic transglycosylase activity
APZ20_RS12950	COG1702	phosphate starvation-inducible protein PhoH
APZ20_RS12970	COG4535	Mg2 and Co2 transporter CorC
APZ20_RS12985	COG1012	belongs to the aldehyde dehydrogenase family
APZ20_RS12995	COG1177	transmembrane transport
APZ20_RS13000	COG1176	ABC-type spermidine putrescine transport system, permease component I
APZ20_RS13005	COG3842	ATPase activity
APZ20_RS13040	COG0174	glutamine synthetase
APZ20_RS13045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_RS13055	COG0477	Major facilitator Superfamily
APZ20_RS13065	COG0243	molybdopterin cofactor binding
APZ20_RS13075	COG2223	nitrite transmembrane transporter activity
APZ20_RS13085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APZ20_RS13090	COG1121	(ABC) transporter
APZ20_RS13100	COG2733	membrane
APZ20_RS13105	COG0784	Response regulator, receiver
APZ20_RS13105	COG2205	protein histidine kinase activity
APZ20_RS13105	COG5002	protein histidine kinase activity
APZ20_RS13115	COG3039	Transposase
APZ20_RS13120	COG2902	Dehydrogenase
APZ20_RS13130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_RS13135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_RS13155	COG1609	Transcriptional regulator
APZ20_RS13160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APZ20_RS13160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ20_RS13165	COG1105	Belongs to the carbohydrate kinase PfkB family
APZ20_RS13170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ20_RS13170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ20_RS13185	COG3039	Transposase
APZ20_RS13300	COG3293	Transposase
APZ20_RS13315	COG0405	Gamma-glutamyltransferase
APZ20_RS13320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APZ20_RS13335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APZ20_RS13340	COG0742	ribosomal rna small subunit methyltransferase
APZ20_RS13410	COG0583	DNA-binding transcription factor activity
APZ20_RS13420	COG3039	Transposase
APZ20_RS13450	COG2963	transposase activity
APZ20_RS13455	COG2801	Transposase and inactivated derivatives
APZ20_RS13495	COG1278	Cold shock
APZ20_RS13515	COG3328	transposase activity
APZ20_RS13545	COG3039	Transposase
APZ20_RS13555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APZ20_RS13570	COG0557	exoribonuclease II activity
APZ20_RS13595	COG1960	acyl-CoA dehydrogenase activity
APZ20_RS13600	COG2226	methyltransferase
APZ20_RS13605	COG0646	methionine synthase
APZ20_RS13605	COG1410	methionine synthase
APZ20_RS13610	COG0646	methionine synthase
APZ20_RS13610	COG1410	methionine synthase
APZ20_RS13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ20_RS13630	COG1609	Transcriptional regulator
APZ20_RS13645	COG2900	Belongs to the SlyX family
APZ20_RS13660	COG0386	Belongs to the glutathione peroxidase family
APZ20_RS13670	COG1725	Transcriptional regulator
APZ20_RS13675	COG1131	(ABC) transporter
APZ20_RS13715	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS13725	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS13735	COG3293	Transposase
APZ20_RS13780	COG2850	peptidyl-arginine hydroxylation
APZ20_RS13815	COG1132	(ABC) transporter
APZ20_RS13825	COG0583	DNA-binding transcription factor activity
APZ20_RS13840	COG1605	Chorismate mutase
APZ20_RS13840	COG0287	Prephenate dehydrogenase
APZ20_RS13845	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APZ20_RS13850	COG0484	heat shock protein binding
APZ20_RS13860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APZ20_RS13870	COG0497	DNA recombination
APZ20_RS13880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_RS13885	COG2914	Belongs to the UPF0125 (RnfH) family
APZ20_RS13895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APZ20_RS13915	COG1960	acyl-CoA dehydrogenase activity
APZ20_RS13925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APZ20_RS13945	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS13965	COG3293	Transposase
APZ20_RS13980	COG2814	Major facilitator Superfamily
APZ20_RS13985	COG1566	PFAM secretion protein HlyD family protein
APZ20_RS14000	COG2207	Transcriptional regulator
APZ20_RS14030	COG4774	siderophore transport
APZ20_RS14045	COG0367	asparagine synthase
APZ20_RS14050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APZ20_RS14060	COG1393	Belongs to the ArsC family
APZ20_RS14120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APZ20_RS14135	COG0233	cytoplasmic translational termination
APZ20_RS14145	COG0575	Belongs to the CDS family
APZ20_RS14155	COG0750	zinc metalloprotease
APZ20_RS14170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APZ20_RS14175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APZ20_RS14195	COG0825	malonyl-CoA metabolic process
APZ20_RS14205	COG4771	TonB-dependent receptor
APZ20_RS14210	COG1131	(ABC) transporter
APZ20_RS14245	COG1981	membrane
APZ20_RS14285	COG0529	Catalyzes the synthesis of activated sulfate
APZ20_RS14285	COG2895	sulfate adenylyltransferase (ATP) activity
APZ20_RS14315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APZ20_RS14335	COG2040	homocysteine
APZ20_RS14340	COG0833	amino acid
APZ20_RS14350	COG0346	lactoylglutathione lyase activity
APZ20_RS14360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APZ20_RS14360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APZ20_RS14370	COG2878	Part of a membrane complex involved in electron transport
APZ20_RS14390	COG1595	DNA-templated transcription, initiation
APZ20_RS14415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APZ20_RS14430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APZ20_RS14435	COG0251	oxidation-reduction process
APZ20_RS14445	COG0392	lysyltransferase activity
APZ20_RS14445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APZ20_RS14480	COG2814	Major facilitator Superfamily
APZ20_RS14485	COG1902	pentaerythritol trinitrate reductase activity
APZ20_RS14495	COG2824	Alkylphosphonate utilization operon protein PhnA
APZ20_RS14510	COG1047	Peptidyl-prolyl cis-trans
APZ20_RS14550	COG3039	Transposase
APZ20_RS14555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APZ20_RS14565	COG1451	nucleotide metabolic process
APZ20_RS14585	COG0183	Belongs to the thiolase family
APZ20_RS14615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APZ20_RS14615	COG1793	dna ligase
APZ20_RS14625	COG1793	dna ligase
APZ20_RS14630	COG1201	RNA secondary structure unwinding
APZ20_RS14655	COG1278	Cold shock
APZ20_RS14660	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APZ20_RS14665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APZ20_RS14675	COG3046	protein related to deoxyribodipyrimidine photolyase
APZ20_RS14680	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
APZ20_RS14685	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APZ20_RS14710	COG2954	triphosphatase activity
APZ20_RS14725	COG1381	Involved in DNA repair and RecF pathway recombination
APZ20_RS14755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APZ20_RS14770	COG1024	Enoyl-CoA hydratase
APZ20_RS14770	COG1250	3-hydroxyacyl-CoA dehydrogenase
APZ20_RS14790	COG1024	Enoyl-CoA hydratase
APZ20_RS14795	COG1960	acyl-CoA dehydrogenase activity
APZ20_RS14820	COG3867	Arabinogalactan endo-beta-1,4-galactanase
APZ20_RS14855	COG3293	Transposase
APZ20_RS14880	COG2353	YceI-like domain
APZ20_RS14890	COG2353	YceI-like domain
APZ20_RS14900	COG1760	l-serine dehydratase
APZ20_RS14910	COG0626	cystathionine gamma-synthase activity
APZ20_RS14915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APZ20_RS14920	COG0739	heme binding
APZ20_RS14930	COG1272	protein, Hemolysin III
APZ20_RS14945	COG0517	IMP dehydrogenase activity
APZ20_RS14945	COG0516	GMP reductase activity
APZ20_RS14950	COG0463	Glycosyl transferase, family 2
APZ20_RS14960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APZ20_RS14970	COG4771	TonB-dependent receptor
APZ20_RS14975	COG1309	transcriptional regulator
APZ20_RS14985	COG1960	acyl-CoA dehydrogenase activity
APZ20_RS15010	COG0509	glycine decarboxylation via glycine cleavage system
APZ20_RS15025	COG0330	HflC and HflK could
APZ20_RS15040	COG3956	TIGRFAM MazG family protein
APZ20_RS15050	COG0494	nUDIX hydrolase
APZ20_RS15060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APZ20_RS15065	COG0837	glucose binding
APZ20_RS15080	COG1388	LysM domain
APZ20_RS15080	COG3858	chitin binding
APZ20_RS15090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APZ20_RS15100	COG1472	Belongs to the glycosyl hydrolase 3 family
APZ20_RS15160	COG3537	Alpha-1,2-mannosidase
APZ20_RS15210	COG1446	asparaginase
APZ20_RS15220	COG2304	oxidoreductase activity
APZ20_RS15255	COG0784	Response regulator, receiver
APZ20_RS15255	COG2198	Histidine kinase
APZ20_RS15255	COG0643	Histidine kinase
APZ20_RS15260	COG0840	transmembrane signaling receptor activity
APZ20_RS15265	COG0835	chemotaxis
APZ20_RS15280	COG0189	ligase activity
APZ20_RS15290	COG1397	ADP-ribosylglycohydrolase
APZ20_RS15300	COG1199	ATP-dependent helicase activity
APZ20_RS15310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APZ20_RS15315	COG1215	transferase activity, transferring glycosyl groups
APZ20_RS15325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APZ20_RS15340	COG0535	radical SAM domain protein
APZ20_RS15345	COG0535	radical SAM domain protein
APZ20_RS15360	COG0837	glucose binding
APZ20_RS15380	COG1643	Atp-dependent helicase
APZ20_RS15385	COG0783	Belongs to the Dps family
APZ20_RS15390	COG0514	ATP-dependent DNA helicase (RecQ)
APZ20_RS15410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APZ20_RS15425	COG3293	Transposase
APZ20_RS15440	COG0602	queuosine metabolic process
APZ20_RS15450	COG2885	chlorophyll binding
APZ20_RS15465	COG0848	biopolymer transport protein
APZ20_RS15475	COG0824	Thioesterase
APZ20_RS15480	COG2255	four-way junction helicase activity
APZ20_RS15490	COG0632	four-way junction helicase activity
APZ20_RS15575	COG2963	transposase activity
APZ20_RS15585	COG2801	Transposase and inactivated derivatives
APZ20_RS15610	COG2801	Transposase and inactivated derivatives
APZ20_RS15615	COG2963	transposase activity
APZ20_RS15635	COG3039	Transposase
APZ20_RS15640	COG3039	Transposase
APZ20_RS15655	COG3039	Transposase
APZ20_RS15675	COG3209	COG3209 Rhs family protein
APZ20_RS15690	COG3328	transposase activity
APZ20_RS15700	COG3209	COG3209 Rhs family protein
APZ20_RS15720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APZ20_RS15725	COG1845	cytochrome c oxidase, subunit III
APZ20_RS15730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APZ20_RS15745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APZ20_RS15750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APZ20_RS15760	COG0196	riboflavin kinase activity
APZ20_RS15765	COG0728	peptidoglycan biosynthetic process
APZ20_RS15770	COG0268	Binds directly to 16S ribosomal RNA
APZ20_RS15775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APZ20_RS15780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APZ20_RS15790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APZ20_RS15795	COG0824	Thioesterase
APZ20_RS15810	COG1946	Acyl-CoA thioesterase
APZ20_RS15820	COG1595	DNA-templated transcription, initiation
APZ20_RS15835	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APZ20_RS15875	COG1877	trehalose-phosphatase activity
APZ20_RS15880	COG3387	PFAM Glycoside hydrolase 15-related
APZ20_RS15905	COG0564	pseudouridine synthase activity
APZ20_RS15910	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_RS15915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APZ20_RS15915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APZ20_RS15925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APZ20_RS15930	COG0045	succinate-CoA ligase (ADP-forming) activity
APZ20_RS15945	COG2184	nucleotidyltransferase activity
APZ20_RS15965	COG2194	sulfuric ester hydrolase activity
APZ20_RS15970	COG4969	Belongs to the N-Me-Phe pilin family
APZ20_RS15980	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APZ20_RS16000	COG3039	Transposase
APZ20_RS16015	COG3039	Transposase
APZ20_RS16025	COG3293	Transposase
APZ20_RS16035	COG1132	(ABC) transporter
APZ20_RS16065	COG0745	RESPONSE REGULATOR receiver
APZ20_RS16070	COG5000	phosphorelay sensor kinase activity
APZ20_RS16070	COG5002	protein histidine kinase activity
APZ20_RS16075	COG0475	glutathione-regulated potassium exporter activity
APZ20_RS16085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APZ20_RS16105	COG1187	pseudouridine synthase activity
APZ20_RS16110	COG5001	Diguanylate cyclase
APZ20_RS16110	COG5002	protein histidine kinase activity
APZ20_RS16235	COG0415	Belongs to the DNA photolyase family
APZ20_RS16240	COG0305	Participates in initiation and elongation during chromosome replication
APZ20_RS16250	COG0367	asparagine synthase
APZ20_RS16275	COG1960	acyl-CoA dehydrogenase activity
APZ20_RS16290	COG0084	hydrolase, TatD family'
APZ20_RS16295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APZ20_RS16340	COG0735	belongs to the Fur family
APZ20_RS16345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APZ20_RS16370	COG3039	Transposase
APZ20_RS16400	COG3039	Transposase
APZ20_RS16425	COG2205	protein histidine kinase activity
APZ20_RS16435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APZ20_RS16445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APZ20_RS16455	COG2198	Histidine kinase
APZ20_RS16455	COG0643	Histidine kinase
APZ20_RS16460	COG0840	transmembrane signaling receptor activity
APZ20_RS16465	COG0835	chemotaxis
APZ20_RS16470	COG2200	EAL domain
APZ20_RS16470	COG2199	diguanylate cyclase activity
APZ20_RS16470	COG2202	Pas domain
APZ20_RS16475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APZ20_RS16490	COG3590	peptidase
APZ20_RS16505	COG0588	phosphoglycerate mutase activity
APZ20_RS16510	COG1515	deoxyribonuclease V activity
APZ20_RS16520	COG1741	Belongs to the pirin family
APZ20_RS16580	COG3039	Transposase
APZ20_RS16630	COG1741	Belongs to the pirin family
APZ20_RS16635	COG1966	Carbon starvation protein
APZ20_RS16640	COG2879	small protein
APZ20_RS16670	COG0604	alcohol dehydrogenase
APZ20_RS16670	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS16670	COG3321	synthase
APZ20_RS16675	COG2203	Gaf domain
APZ20_RS16675	COG5001	Diguanylate cyclase
APZ20_RS16675	COG4251	negative regulation of phosphorylation
APZ20_RS16675	COG3706	GGDEF domain
APZ20_RS16685	COG0629	single-stranded DNA binding
APZ20_RS16690	COG0142	geranyltranstransferase activity
APZ20_RS16720	COG0527	aspartate kinase activity
APZ20_RS16730	COG0384	phenazine biosynthesis protein PhzF
APZ20_RS16735	COG3293	Transposase
APZ20_RS16750	COG1764	response to oxidative stress
APZ20_RS16765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APZ20_RS16770	COG1678	Uncharacterized ACR, COG1678
APZ20_RS16785	COG0519	Catalyzes the synthesis of GMP from XMP
APZ20_RS16810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APZ20_RS16850	COG0693	protein deglycase activity
APZ20_RS16870	COG1959	2 iron, 2 sulfur cluster binding
APZ20_RS16875	COG0719	Fe-S assembly protein
APZ20_RS16880	COG0396	ATPase activity
APZ20_RS16885	COG0719	Fe-S assembly protein
APZ20_RS16890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APZ20_RS16900	COG2146	nitrite reductase [NAD(P)H] activity
APZ20_RS16905	COG3039	Transposase
APZ20_RS16910	COG2963	transposase activity
APZ20_RS16915	COG2801	Transposase and inactivated derivatives
APZ20_RS16945	COG3328	transposase activity
APZ20_RS16955	COG2963	transposase activity
APZ20_RS16980	COG0326	Molecular chaperone. Has ATPase activity
APZ20_RS16985	COG2207	Transcriptional regulator
APZ20_RS17005	COG0657	acetylesterase activity
APZ20_RS17005	COG2755	lipolytic protein G-D-S-L family
APZ20_RS17030	COG0488	(ABC) transporter
APZ20_RS17075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APZ20_RS17075	COG4651	solute:proton antiporter activity
APZ20_RS17080	COG2801	Transposase and inactivated derivatives
APZ20_RS17090	COG4772	TonB-dependent receptor
APZ20_RS17100	COG4264	IucA IucC family
APZ20_RS17105	COG2814	Major facilitator Superfamily
APZ20_RS17115	COG0019	diaminopimelate decarboxylase activity
APZ20_RS17175	COG4206	TonB-dependent receptor
APZ20_RS17190	COG2963	transposase activity
APZ20_RS17205	COG0542	response to heat
APZ20_RS17250	COG0534	Mate efflux family protein
APZ20_RS17265	COG0336	Belongs to the RNA methyltransferase TrmD family
APZ20_RS17270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APZ20_RS17275	COG0228	four-way junction DNA binding
APZ20_RS17300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APZ20_RS17310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APZ20_RS17365	COG1555	photosystem II stabilization
APZ20_RS17370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APZ20_RS17385	COG3178	'Phosphotransferase
APZ20_RS17390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APZ20_RS17400	COG0628	permease
APZ20_RS17410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APZ20_RS17425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APZ20_RS17445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APZ20_RS17450	COG0271	Belongs to the BolA IbaG family
APZ20_RS17460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APZ20_RS17470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APZ20_RS17475	COG1137	ATPase activity
APZ20_RS17490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ20_RS17495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APZ20_RS17500	COG1660	Displays ATPase and GTPase activities
APZ20_RS17510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ20_RS17515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APZ20_RS17520	COG2239	Acts as a magnesium transporter
APZ20_RS17530	COG1294	oxidase, subunit
APZ20_RS17535	COG1271	oxidase subunit
APZ20_RS17545	COG1113	amino acid transport
APZ20_RS17560	COG2197	response regulator
APZ20_RS17565	COG0531	amino acid
APZ20_RS17645	COG0754	glutathionylspermidine amidase activity
APZ20_RS17670	COG1842	Phage shock protein A
APZ20_RS17685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APZ20_RS17700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APZ20_RS17735	COG2201	protein-glutamate methylesterase activity
APZ20_RS17780	COG2201	protein-glutamate methylesterase activity
APZ20_RS17805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APZ20_RS17825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APZ20_RS17860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APZ20_RS17865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ20_RS17900	COG3039	Transposase
APZ20_RS17920	COG0745	RESPONSE REGULATOR receiver
APZ20_RS17925	COG2205	protein histidine kinase activity
APZ20_RS17940	COG3293	Transposase
APZ20_RS17945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APZ20_RS17990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APZ20_RS17990	COG3453	Protein conserved in bacteria
APZ20_RS17995	COG0725	ABC transporter, periplasmic molybdate-binding protein
APZ20_RS18000	COG4149	molybdate abc transporter
APZ20_RS18005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APZ20_RS18025	COG0642	Histidine kinase
APZ20_RS18040	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS18050	COG1022	Amp-dependent synthetase and ligase
APZ20_RS18075	COG1376	ErfK ybiS ycfS ynhG family protein
APZ20_RS18080	COG0739	heme binding
APZ20_RS18085	COG4773	Receptor
APZ20_RS18090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APZ20_RS18095	COG1301	dicarboxylic acid transport
APZ20_RS18115	COG2304	oxidoreductase activity
APZ20_RS18135	COG0714	Associated with various cellular activities
APZ20_RS18185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APZ20_RS18215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APZ20_RS18225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APZ20_RS18250	COG1561	YicC-like family, N-terminal region
APZ20_RS18255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APZ20_RS18270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APZ20_RS18300	COG0006	proline dipeptidase activity
APZ20_RS18325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APZ20_RS18335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APZ20_RS18345	COG2912	Transglutaminase-like superfamily
APZ20_RS18350	COG1773	rubredoxin
APZ20_RS18355	COG0352	thiamine-phosphate diphosphorylase activity
APZ20_RS18380	COG2801	Transposase and inactivated derivatives
APZ20_RS18385	COG2963	transposase activity
APZ20_RS18395	COG0281	malic enzyme
APZ20_RS18395	COG0280	phosphate acetyltransferase
APZ20_RS18415	COG4191	Histidine kinase
APZ20_RS18430	COG0583	DNA-binding transcription factor activity
APZ20_RS18445	COG2197	response regulator
APZ20_RS18455	COG0642	Histidine kinase
APZ20_RS18470	COG2851	Citrate transporter
APZ20_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS18480	COG1609	Transcriptional regulator
APZ20_RS18540	COG0726	polysaccharide deacetylase
APZ20_RS18545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APZ20_RS18590	COG0242	peptide deformylase activity
APZ20_RS18605	COG0714	Associated with various cellular activities
APZ20_RS18625	COG0537	adenosine 5'-monophosphoramidase activity
APZ20_RS18655	COG0314	molybdopterin synthase activity
APZ20_RS18660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APZ20_RS18665	COG0315	cyclic pyranopterin monophosphate synthase activity
APZ20_RS18675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APZ20_RS18680	COG1234	tRNA 3'-trailer cleavage
APZ20_RS18685	COG3642	lipopolysaccharide core region biosynthetic process
APZ20_RS18690	COG0859	PFAM glycosyl transferase family 9
APZ20_RS18700	COG0582	viral genome integration into host DNA
APZ20_RS18770	COG0631	protein serine/threonine phosphatase activity
APZ20_RS18780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APZ20_RS18805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APZ20_RS18845	COG0544	peptidyl-prolyl cis-trans isomerase activity
APZ20_RS18870	COG2963	transposase activity
APZ20_RS18900	COG0473	3-isopropylmalate dehydrogenase activity
APZ20_RS18930	COG4783	chaperone-mediated protein folding
APZ20_RS18945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APZ20_RS18955	COG0438	transferase activity, transferring glycosyl groups
APZ20_RS18960	COG0671	phosphoesterase, PA-phosphatase related
APZ20_RS18965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APZ20_RS18980	COG2833	Protein of unknown function (DUF455)
APZ20_RS19000	COG0285	dihydrofolate synthase activity
APZ20_RS19010	COG0406	alpha-ribazole phosphatase activity
APZ20_RS19040	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APZ20_RS19045	COG4208	sulfate ABC transporter
APZ20_RS19050	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APZ20_RS19055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APZ20_RS19060	COG0156	8-amino-7-oxononanoate synthase activity
APZ20_RS19085	COG0604	alcohol dehydrogenase
APZ20_RS19090	COG1902	pentaerythritol trinitrate reductase activity
APZ20_RS19090	COG0446	pyridine nucleotide-disulphide oxidoreductase
APZ20_RS19105	COG3293	Transposase
APZ20_RS19140	COG0584	glycerophosphoryl diester phosphodiesterase
APZ20_RS19150	COG3293	Transposase
APZ20_RS19170	COG3039	Transposase
APZ20_RS19180	COG0625	glutathione transferase activity
APZ20_RS19190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APZ20_RS19195	COG1217	gtp-binding protein TYPA
APZ20_RS19215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APZ20_RS19235	COG2963	transposase activity
APZ20_RS19285	COG2963	transposase activity
APZ20_RS19310	COG3293	Transposase
APZ20_RS19335	COG3293	Transposase
APZ20_RS19360	COG3781	membrane
APZ20_RS19370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APZ20_RS19410	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APZ20_RS19445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APZ20_RS19455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APZ20_RS19490	COG0066	3-isopropylmalate dehydratase activity
APZ20_RS19495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APZ20_RS19530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APZ20_RS19535	COG1538	Outer membrane efflux protein
APZ20_RS19540	COG1519	Transferase
APZ20_RS19545	COG1560	Kdo2-lipid A biosynthetic process
APZ20_RS19585	COG0308	aminopeptidase N
APZ20_RS19590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APZ20_RS19600	COG0330	HflC and HflK could
APZ20_RS19605	COG0330	HflC and HflK could
APZ20_RS19625	COG0678	peroxiredoxin activity
APZ20_RS19690	COG3829	transcription factor binding
APZ20_RS19715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APZ20_RS19720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APZ20_RS19730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APZ20_RS19735	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS19760	COG1399	metal-binding, possibly nucleic acid-binding protein
APZ20_RS19800	COG1518	maintenance of DNA repeat elements
APZ20_RS19805	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APZ20_RS19845	COG2188	Transcriptional regulator
APZ20_RS19860	COG1450	Type ii and iii secretion system protein
APZ20_RS19875	COG3166	PFAM Fimbrial assembly family protein
APZ20_RS19880	COG3156	type II secretion system protein K
APZ20_RS19885	COG4795	General secretion pathway protein
APZ20_RS19890	COG2165	general secretion pathway protein
APZ20_RS19895	COG4970	Tfp pilus assembly protein FimT
APZ20_RS19900	COG2165	general secretion pathway protein
APZ20_RS19905	COG1459	type II secretion system
APZ20_RS19915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ20_RS19925	COG5295	Hep Hag repeat protein
APZ20_RS19930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APZ20_RS19930	COG0047	phosphoribosylformylglycinamidine synthase activity
APZ20_RS19935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APZ20_RS19940	COG4974	Belongs to the 'phage' integrase family
APZ20_RS19955	COG0795	lipopolysaccharide-transporting ATPase activity
APZ20_RS19965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APZ20_RS19980	COG0525	valine-tRNA ligase activity
APZ20_RS19990	COG2963	transposase activity
APZ20_RS19995	COG2801	Transposase and inactivated derivatives
APZ20_RS20005	COG3039	Transposase
APZ20_RS20030	COG3039	Transposase
APZ20_RS20060	COG1183	phosphatidylcholine synthase activity
APZ20_RS20070	COG0442	prolyl-tRNA aminoacylation
APZ20_RS20085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APZ20_RS20090	COG1127	ABC transporter
APZ20_RS20095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APZ20_RS20095	COG3218	ABC-type transport auxiliary lipoprotein component
APZ20_RS20130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APZ20_RS20135	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APZ20_RS20135	COG0662	Cupin 2, conserved barrel domain protein
APZ20_RS20160	COG2086	electron transfer activity
APZ20_RS20185	COG3328	transposase activity
APZ20_RS20225	COG0626	cystathionine gamma-synthase activity
APZ20_RS20255	COG0625	glutathione transferase activity
APZ20_RS20265	COG0513	Belongs to the DEAD box helicase family
APZ20_RS20275	COG0720	synthase
APZ20_RS20285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APZ20_RS20290	COG1956	GAF domain-containing protein
APZ20_RS20325	COG0339	signal peptide processing
APZ20_RS20365	COG3293	Transposase
APZ20_RS20380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APZ20_RS20385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_RS20390	COG3842	ATPase activity
APZ20_RS20445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APZ20_RS20450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APZ20_RS20455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APZ20_RS20465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APZ20_RS20475	COG0356	it plays a direct role in the translocation of protons across the membrane
APZ20_RS20495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APZ20_RS20505	COG0508	dehydrogenase complex catalyzes the overall conversion of
APZ20_RS20535	COG2011	ABC-type metal ion transport system permease component
APZ20_RS20545	COG0697	spore germination
APZ20_RS20580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APZ20_RS20585	COG1187	pseudouridine synthase activity
APZ20_RS20590	COG2813	Specifically methylates the guanine in position
APZ20_RS20620	COG2202	Pas domain
APZ20_RS20620	COG2205	protein histidine kinase activity
APZ20_RS20645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_RS20695	COG0745	RESPONSE REGULATOR receiver
APZ20_RS20710	COG1404	Belongs to the peptidase S8 family
APZ20_RS20730	COG0842	Transport permease protein
APZ20_RS20735	COG1131	(ABC) transporter
APZ20_RS20740	COG0025	NhaP-type Na H and K H
APZ20_RS20755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APZ20_RS20765	COG1573	uracil-dna glycosylase
APZ20_RS20775	COG3384	dioxygenase
APZ20_RS20790	COG0667	Aldo Keto reductase
APZ20_RS20805	COG3590	peptidase
APZ20_RS20825	COG0531	amino acid
APZ20_RS20835	COG3279	Response regulator of the LytR AlgR family
APZ20_RS20840	COG3279	Response regulator of the LytR AlgR family
APZ20_RS20845	COG2972	Histidine kinase
APZ20_RS20885	COG2963	transposase activity
APZ20_RS20910	COG2204	response regulator
APZ20_RS20920	COG1271	oxidase subunit
APZ20_RS20925	COG1294	oxidase, subunit
APZ20_RS20935	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS20950	COG3039	Transposase
APZ20_RS21010	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
APZ20_RS21020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APZ20_RS21035	COG2963	transposase activity
APZ20_RS21040	COG2801	Transposase and inactivated derivatives
APZ20_RS21075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APZ20_RS21080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APZ20_RS21085	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
APZ20_RS21095	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APZ20_RS21100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ20_RS21115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APZ20_RS21140	COG2963	transposase activity
APZ20_RS21145	COG2801	Transposase and inactivated derivatives
APZ20_RS21285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APZ20_RS21295	COG1560	Kdo2-lipid A biosynthetic process
APZ20_RS21345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APZ20_RS21345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APZ20_RS21350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APZ20_RS21355	COG0242	peptide deformylase activity
APZ20_RS21360	COG1652	LysM domain
APZ20_RS21365	COG0758	DNA mediated transformation
APZ20_RS21370	COG2922	Belongs to the Smg family
APZ20_RS21385	COG1754	DNA topoisomerase type I activity
APZ20_RS21385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APZ20_RS21390	COG0009	L-threonylcarbamoyladenylate synthase
APZ20_RS21405	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS21415	COG0616	signal peptide processing
APZ20_RS21420	COG0534	Mate efflux family protein
APZ20_RS21440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APZ20_RS21460	COG1324	tolerance protein
APZ20_RS21475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APZ20_RS21480	COG0511	ligase activity, forming carbon-carbon bonds
APZ20_RS21490	COG0439	Biotin carboxylase
APZ20_RS21530	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APZ20_RS21565	COG3210	domain, Protein
APZ20_RS21570	COG2831	hemolysin activation secretion protein
APZ20_RS21595	COG2453	phosphatase
APZ20_RS21595	COG0671	phosphoesterase, PA-phosphatase related
APZ20_RS21600	COG2267	carboxylic ester hydrolase activity
APZ20_RS21610	COG2267	carboxylic ester hydrolase activity
APZ20_RS21615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APZ20_RS21630	COG0151	Belongs to the GarS family
APZ20_RS21635	COG1136	(ABC) transporter
APZ20_RS21635	COG0577	efflux transmembrane transporter activity
APZ20_RS21645	COG1289	transmembrane transporter activity
APZ20_RS21660	COG2814	Major facilitator Superfamily
APZ20_RS21680	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APZ20_RS21720	COG0745	RESPONSE REGULATOR receiver
APZ20_RS21730	COG2963	transposase activity
APZ20_RS21770	COG0739	heme binding
APZ20_RS21785	COG2211	Major facilitator Superfamily
APZ20_RS21790	COG0708	Exodeoxyribonuclease III
APZ20_RS21805	COG1192	Involved in chromosome partitioning
APZ20_RS21810	COG1475	DNA binding
APZ20_RS21825	COG0463	Glycosyl transferase, family 2
APZ20_RS21850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APZ20_RS21875	COG4221	oxidoreductase activity
APZ20_RS21880	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS21890	COG1414	Transcriptional regulator
APZ20_RS21900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APZ20_RS21905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APZ20_RS21910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APZ20_RS21920	COG3485	protocatechuate 3,4-dioxygenase
APZ20_RS21925	COG3485	protocatechuate 3,4-dioxygenase
APZ20_RS21935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APZ20_RS21945	COG2963	transposase activity
APZ20_RS21965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ20_RS21970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ20_RS21980	COG0045	succinate-CoA ligase (ADP-forming) activity
APZ20_RS21980	COG1042	CoA-binding domain protein
APZ20_RS21980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APZ20_RS21990	COG2239	Acts as a magnesium transporter
APZ20_RS22005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APZ20_RS22010	COG3387	PFAM Glycoside hydrolase 15-related
APZ20_RS22025	COG3100	YcgL domain-containing protein
APZ20_RS22030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APZ20_RS22040	COG0463	Glycosyl transferase, family 2
APZ20_RS22055	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS22065	COG0156	8-amino-7-oxononanoate synthase activity
APZ20_RS22070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APZ20_RS22075	COG1040	competence protein
APZ20_RS22080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APZ20_RS22090	COG0628	permease
APZ20_RS22100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APZ20_RS22110	COG1595	DNA-templated transcription, initiation
APZ20_RS22115	COG0753	catalase activity
APZ20_RS22165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APZ20_RS22170	COG0180	Tryptophanyl-tRNA synthetase
APZ20_RS22175	COG3237	CsbD-like
APZ20_RS22210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APZ20_RS22225	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APZ20_RS22230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APZ20_RS22230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APZ20_RS22270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APZ20_RS22295	COG1566	PFAM secretion protein HlyD family protein
APZ20_RS22315	COG3039	Transposase
APZ20_RS22325	COG1199	ATP-dependent helicase activity
APZ20_RS22360	COG0583	DNA-binding transcription factor activity
APZ20_RS22405	COG0625	glutathione transferase activity
APZ20_RS22440	COG4555	ABC transporter
APZ20_RS22450	COG1476	TRANSCRIPTIONal
APZ20_RS22475	COG1131	(ABC) transporter
APZ20_RS22480	COG0842	Transport permease protein
APZ20_RS22490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APZ20_RS22530	COG2963	transposase activity
APZ20_RS22540	COG3293	Transposase
APZ20_RS22575	COG1181	Belongs to the D-alanine--D-alanine ligase family
APZ20_RS22590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APZ20_RS22600	COG0564	pseudouridine synthase activity
APZ20_RS22625	COG0339	signal peptide processing
APZ20_RS22650	COG3254	rhamnose metabolic process
APZ20_RS22655	COG0738	Major facilitator superfamily
APZ20_RS22660	COG1414	Transcriptional regulator
APZ20_RS22670	COG3293	Transposase
APZ20_RS22680	COG2205	protein histidine kinase activity
APZ20_RS22695	COG3459	Glycosyltransferase 36 associated
APZ20_RS22700	COG2211	Major facilitator Superfamily
APZ20_RS22705	COG3265	gluconokinase activity
APZ20_RS22710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_RS22730	COG2963	transposase activity
APZ20_RS22735	COG2801	Transposase and inactivated derivatives
APZ20_RS22760	COG3039	Transposase
APZ20_RS22815	COG1127	ABC transporter
APZ20_RS22820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APZ20_RS22825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APZ20_RS22840	COG2853	Lipoprotein
APZ20_RS22860	COG3293	Transposase
APZ20_RS22870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APZ20_RS22880	COG2963	transposase activity
APZ20_RS22915	COG3135	benzoate transporter
APZ20_RS22920	COG3135	benzoate transporter
APZ20_RS22940	COG0676	glucose-6-phosphate 1-epimerase activity
APZ20_RS22970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_RS22980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_RS22985	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_RS22990	COG1064	alcohol dehydrogenase
APZ20_RS23030	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_RS23035	COG4773	Receptor
APZ20_RS23055	COG1522	sequence-specific DNA binding
APZ20_RS23060	COG3186	Phenylalanine-4-hydroxylase
APZ20_RS23070	COG2755	lipolytic protein G-D-S-L family
APZ20_RS23085	COG2963	transposase activity
APZ20_RS23100	COG0656	L-ascorbic acid biosynthetic process
APZ20_RS23105	COG2130	NADP-dependent
APZ20_RS23110	COG0667	Aldo Keto reductase
APZ20_RS23120	COG1187	pseudouridine synthase activity
APZ20_RS23135	COG1643	Atp-dependent helicase
APZ20_RS23140	COG4807	Protein conserved in bacteria
APZ20_RS23145	COG4948	Mandelate Racemase Muconate Lactonizing
APZ20_RS23150	COG0179	Fumarylacetoacetate (FAA) hydrolase
APZ20_RS23155	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_RS23175	COG3507	Belongs to the glycosyl hydrolase 43 family
APZ20_RS23220	COG3162	membrane
APZ20_RS23225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APZ20_RS23240	COG0708	Exodeoxyribonuclease III
APZ20_RS23255	COG2091	lysine biosynthetic process via aminoadipic acid
APZ20_RS23265	COG3540	Alkaline phosphatase
APZ20_RS23290	COG2159	amidohydrolase
APZ20_RS23300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APZ20_RS23305	COG0583	DNA-binding transcription factor activity
APZ20_RS23310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ20_RS23325	COG0210	DNA helicase
APZ20_RS23340	COG0531	amino acid
APZ20_RS23345	COG1322	Protein conserved in bacteria
APZ20_RS23355	COG0386	Belongs to the glutathione peroxidase family
APZ20_RS23370	COG3293	Transposase
APZ20_RS23410	COG0793	Belongs to the peptidase S41A family
APZ20_RS23415	COG4942	peptidase
APZ20_RS23425	COG2234	aminopeptidase activity
APZ20_RS23475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APZ20_RS23480	COG0302	gtp cyclohydrolase
APZ20_RS23500	COG0477	Major facilitator Superfamily
APZ20_RS23585	COG1929	Belongs to the glycerate kinase type-1 family
APZ20_RS23590	COG2271	Major facilitator Superfamily
APZ20_RS23605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APZ20_RS23610	COG0861	Integral membrane protein TerC family
APZ20_RS23620	COG0584	glycerophosphoryl diester phosphodiesterase
APZ20_RS23630	COG0671	phosphoesterase, PA-phosphatase related
APZ20_RS23640	COG0726	polysaccharide deacetylase