locus-tag	class	description
PXO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PXO_RS00020	COG0187	DNA topoisomerase II activity
PXO_RS00030	COG0501	Belongs to the peptidase M48B family
PXO_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PXO_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PXO_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PXO_RS00090	COG4772	TonB-dependent receptor
PXO_RS00100	COG3039	Transposase
PXO_RS00105	COG1304	FMN binding
PXO_RS00125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PXO_RS00130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PXO_RS00160	COG3039	Transposase
PXO_RS00220	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS00245	COG3039	Transposase
PXO_RS00255	COG1090	epimerase
PXO_RS00260	COG0642	Histidine kinase
PXO_RS00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PXO_RS00365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PXO_RS00450	COG1511	domain protein
PXO_RS00450	COG3264	Mechanosensitive ion channel
PXO_RS00460	COG3293	Transposase
PXO_RS00470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PXO_RS00475	COG2354	Protein conserved in bacteria
PXO_RS00480	COG1649	PFAM Uncharacterised BCR, COG1649
PXO_RS00490	COG0297	glycogen (starch) synthase activity
PXO_RS00500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PXO_RS00525	COG0702	epimerase
PXO_RS00530	COG1858	cytochrome C peroxidase
PXO_RS00590	COG0513	Belongs to the DEAD box helicase family
PXO_RS00600	COG3039	Transposase
PXO_RS00620	COG0508	dehydrogenase complex catalyzes the overall conversion of
PXO_RS00670	COG1136	(ABC) transporter
PXO_RS00685	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS00710	COG1272	protein, Hemolysin III
PXO_RS00715	COG1111	helicase
PXO_RS00715	COG1205	dead DEAH box helicase
PXO_RS00770	COG0070	glutamate synthase
PXO_RS00770	COG0067	glutamate synthase
PXO_RS00770	COG0069	glutamate synthase activity
PXO_RS00775	COG0493	'glutamate synthase
PXO_RS00795	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS00825	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PXO_RS00830	COG1609	Transcriptional regulator
PXO_RS00855	COG0366	Alpha amylase catalytic
PXO_RS00860	COG0366	Alpha amylase catalytic
PXO_RS00875	COG3328	transposase activity
PXO_RS00905	COG0606	chelatase, subunit chli
PXO_RS00940	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PXO_RS00945	COG1166	arginine decarboxylase activity
PXO_RS01010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PXO_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS01050	COG2801	Transposase and inactivated derivatives
PXO_RS01060	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PXO_RS01075	COG0210	DNA helicase
PXO_RS01085	COG3132	Protein of unknown function, DUF480
PXO_RS01090	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
PXO_RS01095	COG0284	orotidine-5'-phosphate decarboxylase activity
PXO_RS01125	COG2937	Belongs to the GPAT DAPAT family
PXO_RS01145	COG2963	transposase activity
PXO_RS01150	COG2801	Transposase and inactivated derivatives
PXO_RS01180	COG1752	Esterase of the alpha-beta hydrolase superfamily
PXO_RS01190	COG1119	ATPase activity
PXO_RS01205	COG0517	IMP dehydrogenase activity
PXO_RS01205	COG1125	glycine betaine transport
PXO_RS01220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PXO_RS01225	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
PXO_RS01230	COG3550	peptidyl-serine autophosphorylation
PXO_RS01235	COG1396	sequence-specific DNA binding
PXO_RS01255	COG0489	protein tyrosine kinase activity
PXO_RS01260	COG2062	phosphohistidine phosphatase, SixA
PXO_RS01270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PXO_RS01315	COG1968	undecaprenyl-diphosphatase activity
PXO_RS01320	COG0174	glutamine synthetase
PXO_RS01325	COG0347	Belongs to the P(II) protein family
PXO_RS01330	COG0004	ammonium transporteR
PXO_RS01335	COG3852	Histidine kinase
PXO_RS01340	COG2204	response regulator
PXO_RS01345	COG2032	superoxide dismutase activity
PXO_RS01350	COG2032	superoxide dismutase activity
PXO_RS01385	COG1196	nuclear chromosome segregation
PXO_RS01390	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PXO_RS01395	COG1074	ATP-dependent DNA helicase activity
PXO_RS01405	COG3549	Plasmid maintenance system killer
PXO_RS01490	COG1764	response to oxidative stress
PXO_RS01495	COG1846	Transcriptional regulator
PXO_RS01540	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PXO_RS01550	COG3293	Transposase
PXO_RS01580	COG2211	Major facilitator Superfamily
PXO_RS01600	COG3693	PFAM glycoside hydrolase, family 10
PXO_RS01605	COG3693	PFAM glycoside hydrolase, family 10
PXO_RS01630	COG0246	Mannitol dehydrogenase
PXO_RS01635	COG1472	Belongs to the glycosyl hydrolase 3 family
PXO_RS01645	COG4948	Mandelate Racemase Muconate Lactonizing
PXO_RS01655	COG3661	Belongs to the glycosyl hydrolase 67 family
PXO_RS01670	COG0037	tRNA processing
PXO_RS01675	COG2974	May be involved in recombination
PXO_RS01695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PXO_RS01705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PXO_RS01715	COG0805	protein transport
PXO_RS01725	COG0519	Catalyzes the synthesis of GMP from XMP
PXO_RS01725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PXO_RS01740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PXO_RS01745	COG0752	glycyl-tRNA synthetase alpha subunit
PXO_RS01755	COG0457	Tetratricopeptide repeat
PXO_RS01760	COG4771	TonB-dependent receptor
PXO_RS01775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PXO_RS01795	COG0523	cobalamin synthesis protein
PXO_RS01855	COG1960	acyl-CoA dehydrogenase activity
PXO_RS01860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PXO_RS01865	COG4770	biotin carboxylase activity
PXO_RS01875	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS01920	COG2351	hydroxyisourate hydrolase activity
PXO_RS01940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PXO_RS01965	COG3293	Transposase
PXO_RS01990	COG0084	hydrolase, TatD family'
PXO_RS02000	COG0583	DNA-binding transcription factor activity
PXO_RS02005	COG2814	Major facilitator Superfamily
PXO_RS02015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PXO_RS02020	COG1902	pentaerythritol trinitrate reductase activity
PXO_RS02040	COG0745	RESPONSE REGULATOR receiver
PXO_RS02045	COG2205	protein histidine kinase activity
PXO_RS02050	COG2205	protein histidine kinase activity
PXO_RS02060	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PXO_RS02065	COG0583	DNA-binding transcription factor activity
PXO_RS02100	COG0702	epimerase
PXO_RS02105	COG1733	regulation of RNA biosynthetic process
PXO_RS02160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PXO_RS02175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PXO_RS02205	COG2911	Protein conserved in bacteria
PXO_RS02210	COG0729	surface antigen
PXO_RS02220	COG2963	transposase activity
PXO_RS02230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PXO_RS02235	COG3118	belongs to the thioredoxin family
PXO_RS02245	COG2884	Cell division ATP-binding protein ftsE
PXO_RS02250	COG2177	Part of the ABC transporter FtsEX involved in
PXO_RS02255	COG2201	protein-glutamate methylesterase activity
PXO_RS02260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PXO_RS02265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PXO_RS02275	COG1252	NADH dehydrogenase
PXO_RS02305	COG0459	protein refolding
PXO_RS02315	COG4771	TonB-dependent receptor
PXO_RS02325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PXO_RS02365	COG3386	PFAM SMP-30 Gluconolaconase
PXO_RS02380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PXO_RS02385	COG3293	Transposase
PXO_RS02425	COG0778	Nitroreductase
PXO_RS02430	COG2353	YceI-like domain
PXO_RS02525	COG2963	transposase activity
PXO_RS02530	COG2801	Transposase and inactivated derivatives
PXO_RS02545	COG0408	coproporphyrinogen oxidase activity
PXO_RS02560	COG3039	Transposase
PXO_RS02580	COG0129	dihydroxy-acid dehydratase activity
PXO_RS02590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PXO_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PXO_RS02625	COG0318	PFAM AMP-dependent synthetase and ligase
PXO_RS02630	COG0727	PFAM Uncharacterised protein family (UPF0153)
PXO_RS02635	COG0596	Alpha beta hydrolase
PXO_RS02650	COG3177	Filamentation induced by cAMP protein fic
PXO_RS02655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PXO_RS02670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PXO_RS02695	COG4191	Histidine kinase
PXO_RS02700	COG0028	Belongs to the TPP enzyme family
PXO_RS02715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PXO_RS02720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PXO_RS02750	COG5383	Protein conserved in bacteria
PXO_RS02760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PXO_RS02765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PXO_RS02775	COG1473	amidohydrolase
PXO_RS02785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PXO_RS02785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PXO_RS02790	COG3328	transposase activity
PXO_RS02825	COG2801	Transposase and inactivated derivatives
PXO_RS02830	COG2963	transposase activity
PXO_RS02855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PXO_RS02860	COG0134	indole-3-glycerol-phosphate synthase activity
PXO_RS02870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PXO_RS02875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PXO_RS02885	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PXO_RS02890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PXO_RS02895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PXO_RS02930	COG2801	Transposase and inactivated derivatives
PXO_RS02935	COG2963	transposase activity
PXO_RS02950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PXO_RS02965	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PXO_RS03020	COG3039	Transposase
PXO_RS03035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PXO_RS03060	COG0534	Mate efflux family protein
PXO_RS03065	COG0616	signal peptide processing
PXO_RS03075	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS03090	COG0009	L-threonylcarbamoyladenylate synthase
PXO_RS03095	COG1754	DNA topoisomerase type I activity
PXO_RS03095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PXO_RS03110	COG2922	Belongs to the Smg family
PXO_RS03115	COG0758	DNA mediated transformation
PXO_RS03120	COG1652	LysM domain
PXO_RS03125	COG0242	peptide deformylase activity
PXO_RS03130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PXO_RS03135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PXO_RS03135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PXO_RS03180	COG1560	Kdo2-lipid A biosynthetic process
PXO_RS03190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PXO_RS03330	COG0358	DNA primase activity
PXO_RS03335	COG1295	ribonuclease BN
PXO_RS03350	COG1610	YqeY-like protein
PXO_RS03360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PXO_RS03365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PXO_RS03375	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS03405	COG2133	pyrroloquinoline quinone binding
PXO_RS03410	COG4682	membrane
PXO_RS03430	COG3293	Transposase
PXO_RS03440	COG0531	amino acid
PXO_RS03450	COG3293	Transposase
PXO_RS03475	COG4948	Mandelate Racemase Muconate Lactonizing
PXO_RS03485	COG3023	N-Acetylmuramoyl-L-alanine amidase
PXO_RS03490	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
PXO_RS03560	COG0183	Belongs to the thiolase family
PXO_RS03575	COG0022	dehydrogenase e1 component
PXO_RS03590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PXO_RS03600	COG3483	tryptophan 2,3-dioxygenase activity
PXO_RS03605	COG3104	oligopeptide transport
PXO_RS03625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PXO_RS03630	COG1320	monovalent cation:proton antiporter activity
PXO_RS03635	COG2212	antiporter activity
PXO_RS03645	COG0651	ATP synthesis coupled electron transport
PXO_RS03650	COG1006	Multisubunit Na H antiporter MnhC subunit
PXO_RS03655	COG2111	Na H antiporter
PXO_RS03655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PXO_RS03670	COG3227	Zinc metalloprotease (Elastase)
PXO_RS03710	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PXO_RS03720	COG0456	acetyltransferase
PXO_RS03740	COG2963	transposase activity
PXO_RS03745	COG2801	Transposase and inactivated derivatives
PXO_RS03755	COG4221	oxidoreductase activity
PXO_RS03810	COG0697	spore germination
PXO_RS03815	COG4305	rare lipoprotein A
PXO_RS03820	COG5297	Belongs to the glycosyl hydrolase family 6
PXO_RS03825	COG1113	amino acid transport
PXO_RS03835	COG0598	Magnesium transport protein CorA
PXO_RS03855	COG3039	Transposase
PXO_RS03885	COG3293	Transposase
PXO_RS03915	COG0840	transmembrane signaling receptor activity
PXO_RS03925	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PXO_RS03925	COG5297	Belongs to the glycosyl hydrolase family 6
PXO_RS03930	COG0659	secondary active sulfate transmembrane transporter activity
PXO_RS03960	COG3293	Transposase
PXO_RS03975	COG3275	phosphorelay sensor kinase activity
PXO_RS03985	COG0181	hydroxymethylbilane synthase activity
PXO_RS04010	COG1505	serine-type exopeptidase activity
PXO_RS04020	COG0436	Aminotransferase
PXO_RS04050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PXO_RS04075	COG0308	aminopeptidase N
PXO_RS04080	COG2199	diguanylate cyclase activity
PXO_RS04130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PXO_RS04135	COG1077	Cell shape determining protein MreB Mrl
PXO_RS04140	COG1792	Involved in formation and maintenance of cell shape
PXO_RS04155	COG0772	Belongs to the SEDS family
PXO_RS04190	COG2951	lytic endotransglycosylase activity
PXO_RS04195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PXO_RS04205	COG1686	Belongs to the peptidase S11 family
PXO_RS04215	COG2921	Belongs to the UPF0250 family
PXO_RS04240	COG1056	cytidyltransferase-related domain
PXO_RS04240	COG1051	belongs to the nudix hydrolase family
PXO_RS04280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PXO_RS04285	COG0673	inositol 2-dehydrogenase activity
PXO_RS04290	COG2823	Periplasmic or secreted lipoprotein
PXO_RS04295	COG4251	negative regulation of phosphorylation
PXO_RS04300	COG0784	Response regulator, receiver
PXO_RS04305	COG4191	Histidine kinase
PXO_RS04310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PXO_RS04330	COG2801	Transposase and inactivated derivatives
PXO_RS04340	COG2963	transposase activity
PXO_RS04350	COG3250	beta-galactosidase activity
PXO_RS04365	COG2188	Transcriptional regulator
PXO_RS04375	COG1609	Transcriptional regulator
PXO_RS04380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PXO_RS04385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PXO_RS04395	COG1215	transferase activity, transferring glycosyl groups
PXO_RS04400	COG0726	polysaccharide deacetylase
PXO_RS04400	COG1649	PFAM Uncharacterised BCR, COG1649
PXO_RS04440	COG3293	Transposase
PXO_RS04495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PXO_RS04505	COG3039	Transposase
PXO_RS04510	COG2963	transposase activity
PXO_RS04515	COG2801	Transposase and inactivated derivatives
PXO_RS04520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PXO_RS04545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PXO_RS04590	COG2205	protein histidine kinase activity
PXO_RS04620	COG3791	Glutathione-dependent formaldehyde-activating
PXO_RS04645	COG0488	(ABC) transporter
PXO_RS04665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PXO_RS04685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PXO_RS04685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PXO_RS04705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PXO_RS04710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PXO_RS04715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PXO_RS04740	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PXO_RS04745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PXO_RS04755	COG2205	protein histidine kinase activity
PXO_RS04760	COG0745	RESPONSE REGULATOR receiver
PXO_RS04765	COG0277	FAD linked oxidase domain protein
PXO_RS04770	COG1988	membrane-bound metal-dependent
PXO_RS04775	COG0792	nuclease activity
PXO_RS04805	COG0275	rRNA processing
PXO_RS04810	COG3116	cell division
PXO_RS04825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PXO_RS04830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PXO_RS04845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PXO_RS04850	COG1181	Belongs to the D-alanine--D-alanine ligase family
PXO_RS04855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PXO_RS04870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PXO_RS04880	COG1388	LysM domain
PXO_RS04880	COG4942	peptidase
PXO_RS04885	COG0653	protein targeting
PXO_RS04895	COG0494	nUDIX hydrolase
PXO_RS04905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PXO_RS04915	COG3321	synthase
PXO_RS04915	COG0604	alcohol dehydrogenase
PXO_RS04915	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS04965	COG2226	methyltransferase
PXO_RS04970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PXO_RS05015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PXO_RS05025	COG4106	trans-aconitate 2-methyltransferase activity
PXO_RS05030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PXO_RS05045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PXO_RS05050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PXO_RS05060	COG3039	Transposase
PXO_RS05070	COG0667	Aldo Keto reductase
PXO_RS05105	COG2175	clavaminate synthase activity
PXO_RS05115	COG4181	ATPase activity
PXO_RS05130	COG0642	Histidine kinase
PXO_RS05145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PXO_RS05165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PXO_RS05185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PXO_RS05190	COG2967	ApaG domain
PXO_RS05195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PXO_RS05200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PXO_RS05215	COG0123	including yeast histone deacetylase and acetoin utilization protein
PXO_RS05220	COG2096	Adenosyltransferase
PXO_RS05230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PXO_RS05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PXO_RS05275	COG0583	DNA-binding transcription factor activity
PXO_RS05280	COG0318	PFAM AMP-dependent synthetase and ligase
PXO_RS05290	COG1024	Enoyl-CoA hydratase
PXO_RS05310	COG3386	PFAM SMP-30 Gluconolaconase
PXO_RS05320	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PXO_RS05355	COG3293	Transposase
PXO_RS05365	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS05410	COG3039	Transposase
PXO_RS05425	COG2197	response regulator
PXO_RS05435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PXO_RS05455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PXO_RS05460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PXO_RS05465	COG0583	DNA-binding transcription factor activity
PXO_RS05470	COG3634	alkyl hydroperoxide reductase activity
PXO_RS05480	COG2890	protein-(glutamine-N5) methyltransferase activity
PXO_RS05520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PXO_RS05520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PXO_RS05535	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PXO_RS05560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PXO_RS05585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PXO_RS05595	COG1404	Belongs to the peptidase S8 family
PXO_RS05600	COG1404	Belongs to the peptidase S8 family
PXO_RS05605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PXO_RS05630	COG1295	ribonuclease BN
PXO_RS05635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PXO_RS05655	COG0521	Mo-molybdopterin cofactor biosynthetic process
PXO_RS05665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PXO_RS05670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PXO_RS05680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PXO_RS05695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PXO_RS05705	COG0193	aminoacyl-tRNA hydrolase activity
PXO_RS05710	COG0012	GTP binding
PXO_RS05740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PXO_RS05745	COG0250	Participates in transcription elongation, termination and antitermination
PXO_RS05750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PXO_RS05755	COG0081	regulation of translation
PXO_RS05760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PXO_RS05765	COG0222	ribosome binding
PXO_RS05770	COG0085	RNA polymerase activity
PXO_RS05775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PXO_RS05780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PXO_RS05785	COG0049	tRNA binding
PXO_RS05805	COG0051	transcription antitermination factor activity, RNA binding
PXO_RS05810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PXO_RS05815	COG0088	Forms part of the polypeptide exit tunnel
PXO_RS05820	COG0089	rRNA binding
PXO_RS05845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PXO_RS05850	COG0255	Belongs to the universal ribosomal protein uL29 family
PXO_RS05855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PXO_RS05860	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PXO_RS05865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PXO_RS05870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PXO_RS05890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PXO_RS05900	COG1841	ribosomal large subunit assembly
PXO_RS05910	COG0201	protein transport
PXO_RS05920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PXO_RS05925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PXO_RS05935	COG0203	ribosomal protein L17
PXO_RS05950	COG3293	Transposase
PXO_RS05960	COG2963	transposase activity
PXO_RS06005	COG3551	Protein conserved in bacteria
PXO_RS06035	COG2194	sulfuric ester hydrolase activity
PXO_RS06045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PXO_RS06050	COG0745	RESPONSE REGULATOR receiver
PXO_RS06055	COG0642	Histidine kinase
PXO_RS06065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PXO_RS06070	COG2894	cell division
PXO_RS06085	COG4585	Histidine kinase
PXO_RS06090	COG2197	response regulator
PXO_RS06105	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PXO_RS06130	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PXO_RS06135	COG2963	transposase activity
PXO_RS06195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PXO_RS06205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PXO_RS06220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PXO_RS06240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PXO_RS06265	COG3039	Transposase
PXO_RS06280	COG3039	Transposase
PXO_RS06295	COG3039	Transposase
PXO_RS06315	COG1741	Belongs to the pirin family
PXO_RS06325	COG1515	deoxyribonuclease V activity
PXO_RS06330	COG0588	phosphoglycerate mutase activity
PXO_RS06345	COG3590	peptidase
PXO_RS06360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PXO_RS06365	COG2199	diguanylate cyclase activity
PXO_RS06365	COG2200	EAL domain
PXO_RS06365	COG2202	Pas domain
PXO_RS06370	COG0835	chemotaxis
PXO_RS06375	COG0840	transmembrane signaling receptor activity
PXO_RS06380	COG0643	Histidine kinase
PXO_RS06380	COG2198	Histidine kinase
PXO_RS06385	COG3039	Transposase
PXO_RS06390	COG0643	Histidine kinase
PXO_RS06390	COG2198	Histidine kinase
PXO_RS06400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PXO_RS06410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PXO_RS06415	COG2205	protein histidine kinase activity
PXO_RS06440	COG3039	Transposase
PXO_RS06490	COG3039	Transposase
PXO_RS06515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PXO_RS06520	COG0735	belongs to the Fur family
PXO_RS06560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PXO_RS06565	COG0084	hydrolase, TatD family'
PXO_RS06580	COG1960	acyl-CoA dehydrogenase activity
PXO_RS06605	COG0367	asparagine synthase
PXO_RS06615	COG0305	Participates in initiation and elongation during chromosome replication
PXO_RS06620	COG0415	Belongs to the DNA photolyase family
PXO_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS06745	COG5001	Diguanylate cyclase
PXO_RS06745	COG5002	protein histidine kinase activity
PXO_RS06750	COG1187	pseudouridine synthase activity
PXO_RS06765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PXO_RS06775	COG0475	glutathione-regulated potassium exporter activity
PXO_RS06780	COG5000	phosphorelay sensor kinase activity
PXO_RS06780	COG5002	protein histidine kinase activity
PXO_RS06785	COG0745	RESPONSE REGULATOR receiver
PXO_RS06815	COG1132	(ABC) transporter
PXO_RS06835	COG3293	Transposase
PXO_RS06850	COG3039	Transposase
PXO_RS06855	COG3209	COG3209 Rhs family protein
PXO_RS06860	COG3039	Transposase
PXO_RS06880	COG3039	Transposase
PXO_RS06890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PXO_RS06900	COG4969	Belongs to the N-Me-Phe pilin family
PXO_RS06905	COG2194	sulfuric ester hydrolase activity
PXO_RS06925	COG2184	nucleotidyltransferase activity
PXO_RS06945	COG0045	succinate-CoA ligase (ADP-forming) activity
PXO_RS06950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PXO_RS06960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PXO_RS06960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PXO_RS06965	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PXO_RS06970	COG0564	pseudouridine synthase activity
PXO_RS06995	COG3387	PFAM Glycoside hydrolase 15-related
PXO_RS07000	COG1877	trehalose-phosphatase activity
PXO_RS07040	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PXO_RS07055	COG1595	DNA-templated transcription, initiation
PXO_RS07065	COG1946	Acyl-CoA thioesterase
PXO_RS07080	COG0824	Thioesterase
PXO_RS07085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PXO_RS07095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PXO_RS07100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PXO_RS07105	COG0268	Binds directly to 16S ribosomal RNA
PXO_RS07110	COG0728	peptidoglycan biosynthetic process
PXO_RS07115	COG0196	riboflavin kinase activity
PXO_RS07125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PXO_RS07130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PXO_RS07145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PXO_RS07150	COG1845	cytochrome c oxidase, subunit III
PXO_RS07155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PXO_RS07175	COG3209	COG3209 Rhs family protein
PXO_RS07210	COG3209	COG3209 Rhs family protein
PXO_RS07210	COG3209	COG3209 Rhs family protein
PXO_RS07215	COG3039	Transposase
PXO_RS07255	COG3039	Transposase
PXO_RS07315	COG3039	Transposase
PXO_RS07370	COG3039	Transposase
PXO_RS07415	COG0631	protein serine/threonine phosphatase activity
PXO_RS07420	COG0515	serine threonine protein kinase
PXO_RS07445	COG1858	cytochrome C peroxidase
PXO_RS07455	COG4644	lycopene metabolic process
PXO_RS07470	COG2963	transposase activity
PXO_RS07515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PXO_RS07520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PXO_RS07535	COG2201	protein-glutamate methylesterase activity
PXO_RS07565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PXO_RS07585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PXO_RS07600	COG1595	DNA-templated transcription, initiation
PXO_RS07650	COG2244	polysaccharide biosynthetic process
PXO_RS07680	COG2264	protein methyltransferase activity
PXO_RS07690	COG0438	transferase activity, transferring glycosyl groups
PXO_RS07705	COG1136	(ABC) transporter
PXO_RS07710	COG1132	(ABC) transporter
PXO_RS07715	COG0477	Major facilitator Superfamily
PXO_RS07720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PXO_RS07735	COG1253	flavin adenine dinucleotide binding
PXO_RS07745	COG0306	phosphate transporter
PXO_RS07780	COG0504	CTP synthase activity
PXO_RS07785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PXO_RS07795	COG0148	phosphopyruvate hydratase activity
PXO_RS07800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PXO_RS07805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PXO_RS07810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PXO_RS07820	COG2840	Smr protein MutS2
PXO_RS07825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PXO_RS07830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PXO_RS07835	COG1238	metal cluster binding
PXO_RS07850	COG1534	Rna-binding protein
PXO_RS07855	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PXO_RS07865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PXO_RS07870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PXO_RS07880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PXO_RS07885	COG1546	Belongs to the CinA family
PXO_RS07900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PXO_RS07905	COG2137	regulation of response to DNA damage stimulus
PXO_RS07910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PXO_RS07915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PXO_RS07935	COG0305	Participates in initiation and elongation during chromosome replication
PXO_RS07940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PXO_RS07970	COG1741	Belongs to the pirin family
PXO_RS07975	COG0583	DNA-binding transcription factor activity
PXO_RS08005	COG0351	phosphomethylpyrimidine kinase
PXO_RS08015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PXO_RS08020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PXO_RS08035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PXO_RS08045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PXO_RS08050	COG3734	2-keto-3-deoxy-galactonokinase
PXO_RS08060	COG4948	Mandelate Racemase Muconate Lactonizing
PXO_RS08065	COG0800	Aldolase
PXO_RS08080	COG1501	Belongs to the glycosyl hydrolase 31 family
PXO_RS08095	COG1070	Carbohydrate kinase
PXO_RS08105	COG0477	Major facilitator Superfamily
PXO_RS08125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PXO_RS08175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PXO_RS08180	COG2258	MOSC domain
PXO_RS08185	COG3293	Transposase
PXO_RS08195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PXO_RS08200	COG0505	Belongs to the CarA family
PXO_RS08210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PXO_RS08215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PXO_RS08225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PXO_RS08260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PXO_RS08265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PXO_RS08280	COG0784	Response regulator, receiver
PXO_RS08280	COG2198	Histidine kinase
PXO_RS08280	COG2205	protein histidine kinase activity
PXO_RS08285	COG1024	Enoyl-CoA hydratase
PXO_RS08290	COG0318	PFAM AMP-dependent synthetase and ligase
PXO_RS08320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PXO_RS08345	COG0840	transmembrane signaling receptor activity
PXO_RS08365	COG0835	chemotaxis
PXO_RS08385	COG0840	transmembrane signaling receptor activity
PXO_RS08390	COG0840	transmembrane signaling receptor activity
PXO_RS08395	COG0840	transmembrane signaling receptor activity
PXO_RS08400	COG0840	transmembrane signaling receptor activity
PXO_RS08405	COG0840	transmembrane signaling receptor activity
PXO_RS08415	COG0840	transmembrane signaling receptor activity
PXO_RS08445	COG0745	RESPONSE REGULATOR receiver
PXO_RS08455	COG0835	chemotaxis
PXO_RS08465	COG1360	Flagellar Motor Protein
PXO_RS08470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PXO_RS08490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PXO_RS08500	COG4771	TonB-dependent receptor
PXO_RS08620	COG3039	Transposase
PXO_RS08630	COG3039	Transposase
PXO_RS08645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PXO_RS08645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PXO_RS08650	COG1105	Belongs to the carbohydrate kinase PfkB family
PXO_RS08655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PXO_RS08655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PXO_RS08660	COG1609	Transcriptional regulator
PXO_RS08675	COG3293	Transposase
PXO_RS08690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PXO_RS08695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PXO_RS08705	COG2902	Dehydrogenase
PXO_RS08710	COG3039	Transposase
PXO_RS08720	COG2205	protein histidine kinase activity
PXO_RS08720	COG0784	Response regulator, receiver
PXO_RS08720	COG5002	protein histidine kinase activity
PXO_RS08725	COG2733	membrane
PXO_RS08735	COG1121	(ABC) transporter
PXO_RS08740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PXO_RS08750	COG2223	nitrite transmembrane transporter activity
PXO_RS08760	COG0243	molybdopterin cofactor binding
PXO_RS08770	COG0477	Major facilitator Superfamily
PXO_RS08780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PXO_RS08785	COG0174	glutamine synthetase
PXO_RS08820	COG3842	ATPase activity
PXO_RS08825	COG1176	ABC-type spermidine putrescine transport system, permease component I
PXO_RS08830	COG1177	transmembrane transport
PXO_RS08840	COG1012	belongs to the aldehyde dehydrogenase family
PXO_RS08855	COG4535	Mg2 and Co2 transporter CorC
PXO_RS08875	COG1702	phosphate starvation-inducible protein PhoH
PXO_RS08880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PXO_RS08900	COG0741	lytic transglycosylase activity
PXO_RS08905	COG0723	plastoquinol--plastocyanin reductase activity
PXO_RS08910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PXO_RS08915	COG2857	Cytochrome c1
PXO_RS08920	COG0625	glutathione transferase activity
PXO_RS08925	COG2969	positive regulation of protein catabolic process
PXO_RS08955	COG3328	transposase activity
PXO_RS09015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PXO_RS09030	COG1570	exodeoxyribonuclease VII activity
PXO_RS09035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PXO_RS09040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PXO_RS09040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PXO_RS09045	COG0802	atpase or kinase
PXO_RS09050	COG0860	N-Acetylmuramoyl-L-alanine amidase
PXO_RS09055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PXO_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS09085	COG0501	Belongs to the peptidase M48B family
PXO_RS09095	COG2081	HI0933 family
PXO_RS09100	COG4681	YaeQ
PXO_RS09105	COG1671	Belongs to the UPF0178 family
PXO_RS09115	COG0625	glutathione transferase activity
PXO_RS09125	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PXO_RS09130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PXO_RS09135	COG0513	Belongs to the DEAD box helicase family
PXO_RS09140	COG0488	(ABC) transporter
PXO_RS09160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PXO_RS09165	COG0483	inositol monophosphate 1-phosphatase activity
PXO_RS09180	COG5001	Diguanylate cyclase
PXO_RS09180	COG3300	MHYT domain
PXO_RS09185	COG1509	lysine 2,3-aminomutase activity
PXO_RS09200	COG0402	S-adenosylhomocysteine deaminase activity
PXO_RS09205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PXO_RS09240	COG4677	pectinesterase activity
PXO_RS09260	COG3039	Transposase
PXO_RS09280	COG4302	ethanolamine ammonia-lyase activity
PXO_RS09290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PXO_RS09320	COG2166	iron-sulfur cluster assembly
PXO_RS09335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PXO_RS09340	COG0137	argininosuccinate synthase activity
PXO_RS09350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PXO_RS09355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PXO_RS09370	COG0165	Argininosuccinate lyase
PXO_RS09390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PXO_RS09415	COG1294	oxidase, subunit
PXO_RS09420	COG1271	oxidase subunit
PXO_RS09430	COG4988	ABC transporter
PXO_RS09435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PXO_RS09560	COG0742	ribosomal rna small subunit methyltransferase
PXO_RS09565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PXO_RS09580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PXO_RS09585	COG0405	Gamma-glutamyltransferase
PXO_RS09600	COG3293	Transposase
PXO_RS09650	COG3039	Transposase
PXO_RS09695	COG0343	queuine tRNA-ribosyltransferase activity
PXO_RS09700	COG1862	Preprotein translocase
PXO_RS09705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PXO_RS09710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PXO_RS09740	COG3328	transposase activity
PXO_RS09755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PXO_RS09765	COG0704	Plays a role in the regulation of phosphate uptake
PXO_RS09780	COG0573	inorganic phosphate transmembrane transporter activity
PXO_RS09785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PXO_RS09805	COG3293	Transposase
PXO_RS09825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PXO_RS09835	COG1024	Enoyl-CoA hydratase
PXO_RS09845	COG0494	nUDIX hydrolase
PXO_RS09880	COG0488	(ABC) transporter
PXO_RS09885	COG4133	protoheme IX ABC transporter activity
PXO_RS09890	COG0488	(ABC) transporter
PXO_RS09895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PXO_RS09895	COG0116	Belongs to the methyltransferase superfamily
PXO_RS09915	COG0667	Aldo Keto reductase
PXO_RS09925	COG2925	Exonuclease
PXO_RS09935	COG3844	kynureninase activity
PXO_RS09950	COG0288	reversible hydration of carbon dioxide
PXO_RS09985	COG0316	Belongs to the HesB IscA family
PXO_RS09990	COG0360	Binds together with S18 to 16S ribosomal RNA
PXO_RS10000	COG0359	binds to the 23S rRNA
PXO_RS10010	COG3115	cell septum assembly
PXO_RS10025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PXO_RS10035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PXO_RS10045	COG2963	transposase activity
PXO_RS10065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PXO_RS10075	COG2986	histidine ammonia-lyase
PXO_RS10080	COG1228	amidohydrolase
PXO_RS10120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PXO_RS10125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PXO_RS10130	COG1605	Chorismate mutase
PXO_RS10130	COG0077	Prephenate dehydratase
PXO_RS10135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PXO_RS10145	COG2963	transposase activity
PXO_RS10155	COG4566	intracellular signal transduction
PXO_RS10210	COG0860	N-Acetylmuramoyl-L-alanine amidase
PXO_RS10215	COG1469	GTP cyclohydrolase I activity
PXO_RS10225	COG0617	tRNA 3'-terminal CCA addition
PXO_RS10235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PXO_RS10240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PXO_RS10250	COG0166	Belongs to the GPI family
PXO_RS10270	COG1472	Belongs to the glycosyl hydrolase 3 family
PXO_RS10280	COG2203	Gaf domain
PXO_RS10280	COG3706	GGDEF domain
PXO_RS10280	COG4251	negative regulation of phosphorylation
PXO_RS10280	COG5001	Diguanylate cyclase
PXO_RS10365	COG0386	Belongs to the glutathione peroxidase family
PXO_RS10435	COG3293	Transposase
PXO_RS10445	COG1247	-acetyltransferase
PXO_RS10470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PXO_RS10500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PXO_RS10515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PXO_RS10525	COG0431	NADPH-dependent FMN reductase
PXO_RS10530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PXO_RS10535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PXO_RS10555	COG3293	Transposase
PXO_RS10565	COG5002	protein histidine kinase activity
PXO_RS10565	COG0784	Response regulator, receiver
PXO_RS10565	COG2205	protein histidine kinase activity
PXO_RS10590	COG3293	Transposase
PXO_RS10610	COG0800	Aldolase
PXO_RS10615	COG0129	dihydroxy-acid dehydratase activity
PXO_RS10620	COG0363	glucosamine-6-phosphate deaminase activity
PXO_RS10630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PXO_RS10640	COG0354	folic acid binding
PXO_RS10650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PXO_RS10665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PXO_RS10680	COG4591	ABC-type transport system involved in lipoprotein release permease component
PXO_RS10705	COG0811	peptide transport
PXO_RS10720	COG1663	tetraacyldisaccharide 4'-kinase activity
PXO_RS10730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PXO_RS10740	COG0322	excinuclease ABC activity
PXO_RS10775	COG3328	transposase activity
PXO_RS10790	COG2801	Transposase and inactivated derivatives
PXO_RS10800	COG2201	protein-glutamate methylesterase activity
PXO_RS10880	COG3293	Transposase
PXO_RS10940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PXO_RS10940	COG0140	phosphoribosyl-ATP diphosphatase activity
PXO_RS10950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PXO_RS10960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PXO_RS10960	COG0131	Imidazoleglycerol-phosphate dehydratase
PXO_RS10975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PXO_RS11000	COG0124	histidyl-tRNA synthetase
PXO_RS11015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PXO_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
PXO_RS11075	COG0167	dihydroorotate dehydrogenase activity
PXO_RS11080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PXO_RS11085	COG0697	spore germination
PXO_RS11090	COG1794	racemase activity, acting on amino acids and derivatives
PXO_RS11105	COG0671	phosphoesterase, PA-phosphatase related
PXO_RS11120	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PXO_RS11130	COG2183	response to ionizing radiation
PXO_RS11140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PXO_RS11140	COG0723	plastoquinol--plastocyanin reductase activity
PXO_RS11155	COG3243	poly(R)-hydroxyalkanoic acid synthase
PXO_RS11165	COG1183	phosphatidylcholine synthase activity
PXO_RS11170	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS11185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PXO_RS11195	COG0668	transmembrane transport
PXO_RS11215	COG1914	H( )-stimulated, divalent metal cation uptake system
PXO_RS11230	COG0583	DNA-binding transcription factor activity
PXO_RS11235	COG0583	DNA-binding transcription factor activity
PXO_RS11250	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS11255	COG0583	DNA-binding transcription factor activity
PXO_RS11260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PXO_RS11265	COG3002	Belongs to the UPF0753 family
PXO_RS11270	COG0519	Catalyzes the synthesis of GMP from XMP
PXO_RS11270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PXO_RS11280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PXO_RS11315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PXO_RS11315	COG0475	glutathione-regulated potassium exporter activity
PXO_RS11320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PXO_RS11330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PXO_RS11335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PXO_RS11345	COG0776	regulation of translation
PXO_RS11350	COG0539	negative regulation of cytoplasmic translation
PXO_RS11355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PXO_RS11370	COG2957	Belongs to the agmatine deiminase family
PXO_RS11375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PXO_RS11400	COG0395	ABC-type sugar transport system, permease component
PXO_RS11405	COG1175	transmembrane transport
PXO_RS11435	COG2350	Protein conserved in bacteria
PXO_RS11440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PXO_RS11445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PXO_RS11450	COG1187	pseudouridine synthase activity
PXO_RS11475	COG0436	Aminotransferase
PXO_RS11540	COG0277	FAD linked oxidase domain protein
PXO_RS11545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PXO_RS11555	COG0531	amino acid
PXO_RS11560	COG0531	amino acid
PXO_RS11565	COG0235	Class ii aldolase
PXO_RS11570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PXO_RS11575	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PXO_RS11595	COG3039	Transposase
PXO_RS11605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PXO_RS11640	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS11675	COG0303	'Molybdopterin
PXO_RS11685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PXO_RS11695	COG1426	Protein conserved in bacteria
PXO_RS11705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PXO_RS11720	COG1024	Enoyl-CoA hydratase
PXO_RS11720	COG1250	3-hydroxyacyl-CoA dehydrogenase
PXO_RS11725	COG0183	Belongs to the thiolase family
PXO_RS11730	COG0038	chloride channel
PXO_RS11750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PXO_RS11770	COG1674	ftsk spoiiie
PXO_RS11775	COG0492	ferredoxin-NADP+ reductase activity
PXO_RS11805	COG0542	response to heat
PXO_RS11820	COG0482	sulfurtransferase activity
PXO_RS11845	COG5001	Diguanylate cyclase
PXO_RS11850	COG4585	Histidine kinase
PXO_RS11860	COG5002	protein histidine kinase activity
PXO_RS11880	COG0835	chemotaxis
PXO_RS11880	COG0784	Response regulator, receiver
PXO_RS11890	COG1558	bacterial-type flagellum-dependent cell motility
PXO_RS11895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PXO_RS11905	COG4787	bacterial-type flagellum-dependent cell motility
PXO_RS11940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PXO_RS11945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PXO_RS11975	COG2201	protein-glutamate methylesterase activity
PXO_RS11995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PXO_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS12035	COG1677	Flagellar hook-basal body complex protein FliE
PXO_RS12085	COG3190	flagellar
PXO_RS12105	COG1684	flagellar biosynthetic protein fliR
PXO_RS12160	COG2198	Histidine kinase
PXO_RS12160	COG0784	Response regulator, receiver
PXO_RS12160	COG0643	Histidine kinase
PXO_RS12180	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS12195	COG3209	COG3209 Rhs family protein
PXO_RS12220	COG3209	COG3209 Rhs family protein
PXO_RS12275	COG0583	DNA-binding transcription factor activity
PXO_RS12285	COG3039	Transposase
PXO_RS12320	COG2963	transposase activity
PXO_RS12325	COG2801	Transposase and inactivated derivatives
PXO_RS12375	COG1278	Cold shock
PXO_RS12385	COG3328	transposase activity
PXO_RS12405	COG0436	Aminotransferase
PXO_RS12470	COG0277	FAD linked oxidase domain protein
PXO_RS12475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PXO_RS12485	COG0531	amino acid
PXO_RS12490	COG0531	amino acid
PXO_RS12495	COG0235	Class ii aldolase
PXO_RS12500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PXO_RS12505	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PXO_RS12525	COG3039	Transposase
PXO_RS12535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PXO_RS12570	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS12605	COG0303	'Molybdopterin
PXO_RS12615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PXO_RS12625	COG1426	Protein conserved in bacteria
PXO_RS12635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PXO_RS12650	COG1024	Enoyl-CoA hydratase
PXO_RS12650	COG1250	3-hydroxyacyl-CoA dehydrogenase
PXO_RS12655	COG0183	Belongs to the thiolase family
PXO_RS12660	COG0038	chloride channel
PXO_RS12680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PXO_RS12700	COG1674	ftsk spoiiie
PXO_RS12705	COG0492	ferredoxin-NADP+ reductase activity
PXO_RS12735	COG0542	response to heat
PXO_RS12750	COG0482	sulfurtransferase activity
PXO_RS12775	COG5001	Diguanylate cyclase
PXO_RS12780	COG4585	Histidine kinase
PXO_RS12790	COG5002	protein histidine kinase activity
PXO_RS12810	COG0835	chemotaxis
PXO_RS12810	COG0784	Response regulator, receiver
PXO_RS12820	COG1558	bacterial-type flagellum-dependent cell motility
PXO_RS12825	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PXO_RS12835	COG4787	bacterial-type flagellum-dependent cell motility
PXO_RS12870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PXO_RS12875	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PXO_RS12905	COG2201	protein-glutamate methylesterase activity
PXO_RS12925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PXO_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS12965	COG1677	Flagellar hook-basal body complex protein FliE
PXO_RS13015	COG3190	flagellar
PXO_RS13035	COG1684	flagellar biosynthetic protein fliR
PXO_RS13090	COG0643	Histidine kinase
PXO_RS13090	COG2198	Histidine kinase
PXO_RS13090	COG0784	Response regulator, receiver
PXO_RS13110	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS13125	COG3209	COG3209 Rhs family protein
PXO_RS13150	COG3209	COG3209 Rhs family protein
PXO_RS13205	COG0583	DNA-binding transcription factor activity
PXO_RS13215	COG3039	Transposase
PXO_RS13250	COG2963	transposase activity
PXO_RS13255	COG2801	Transposase and inactivated derivatives
PXO_RS13305	COG1278	Cold shock
PXO_RS13315	COG3328	transposase activity
PXO_RS13350	COG3039	Transposase
PXO_RS13360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PXO_RS13370	COG0557	exoribonuclease II activity
PXO_RS13390	COG1960	acyl-CoA dehydrogenase activity
PXO_RS13395	COG2226	methyltransferase
PXO_RS13400	COG0646	methionine synthase
PXO_RS13400	COG1410	methionine synthase
PXO_RS13405	COG0646	methionine synthase
PXO_RS13405	COG1410	methionine synthase
PXO_RS13415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PXO_RS13425	COG1609	Transcriptional regulator
PXO_RS13440	COG2900	Belongs to the SlyX family
PXO_RS13455	COG0386	Belongs to the glutathione peroxidase family
PXO_RS13460	COG1725	Transcriptional regulator
PXO_RS13465	COG1131	(ABC) transporter
PXO_RS13505	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS13515	COG3293	Transposase
PXO_RS13550	COG2850	peptidyl-arginine hydroxylation
PXO_RS13585	COG1132	(ABC) transporter
PXO_RS13590	COG0583	DNA-binding transcription factor activity
PXO_RS13605	COG1605	Chorismate mutase
PXO_RS13605	COG0287	Prephenate dehydrogenase
PXO_RS13610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PXO_RS13615	COG0484	heat shock protein binding
PXO_RS13620	COG0443	Heat shock 70 kDa protein
PXO_RS13625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PXO_RS13635	COG0497	DNA recombination
PXO_RS13645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PXO_RS13650	COG2914	Belongs to the UPF0125 (RnfH) family
PXO_RS13660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PXO_RS13680	COG1960	acyl-CoA dehydrogenase activity
PXO_RS13690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PXO_RS13710	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS13730	COG3293	Transposase
PXO_RS13745	COG2814	Major facilitator Superfamily
PXO_RS13750	COG1566	PFAM secretion protein HlyD family protein
PXO_RS13765	COG2207	Transcriptional regulator
PXO_RS13795	COG4774	siderophore transport
PXO_RS13810	COG0367	asparagine synthase
PXO_RS13815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PXO_RS13825	COG1393	Belongs to the ArsC family
PXO_RS13885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PXO_RS13900	COG0233	cytoplasmic translational termination
PXO_RS13910	COG0575	Belongs to the CDS family
PXO_RS13915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PXO_RS13920	COG0750	zinc metalloprotease
PXO_RS13945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PXO_RS13950	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PXO_RS13970	COG0825	malonyl-CoA metabolic process
PXO_RS13980	COG4771	TonB-dependent receptor
PXO_RS13985	COG1131	(ABC) transporter
PXO_RS14010	COG1981	membrane
PXO_RS14045	COG2895	sulfate adenylyltransferase (ATP) activity
PXO_RS14045	COG0529	Catalyzes the synthesis of activated sulfate
PXO_RS14080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PXO_RS14095	COG2040	homocysteine
PXO_RS14100	COG0833	amino acid
PXO_RS14110	COG0346	lactoylglutathione lyase activity
PXO_RS14120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PXO_RS14120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PXO_RS14130	COG2878	Part of a membrane complex involved in electron transport
PXO_RS14150	COG1595	DNA-templated transcription, initiation
PXO_RS14175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PXO_RS14190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PXO_RS14195	COG0251	oxidation-reduction process
PXO_RS14205	COG0392	lysyltransferase activity
PXO_RS14205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PXO_RS14235	COG2814	Major facilitator Superfamily
PXO_RS14240	COG1902	pentaerythritol trinitrate reductase activity
PXO_RS14255	COG2824	Alkylphosphonate utilization operon protein PhnA
PXO_RS14270	COG1047	Peptidyl-prolyl cis-trans
PXO_RS14305	COG3039	Transposase
PXO_RS14310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PXO_RS14330	COG1451	nucleotide metabolic process
PXO_RS14345	COG0183	Belongs to the thiolase family
PXO_RS14375	COG1793	dna ligase
PXO_RS14375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PXO_RS14385	COG1793	dna ligase
PXO_RS14390	COG1201	RNA secondary structure unwinding
PXO_RS14410	COG1278	Cold shock
PXO_RS14415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PXO_RS14420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PXO_RS14430	COG3046	protein related to deoxyribodipyrimidine photolyase
PXO_RS14435	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PXO_RS14445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PXO_RS14450	COG2954	triphosphatase activity
PXO_RS14465	COG1381	Involved in DNA repair and RecF pathway recombination
PXO_RS14490	COG0481	GTPase activity
PXO_RS14495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PXO_RS14510	COG1024	Enoyl-CoA hydratase
PXO_RS14510	COG1250	3-hydroxyacyl-CoA dehydrogenase
PXO_RS14530	COG1024	Enoyl-CoA hydratase
PXO_RS14535	COG1960	acyl-CoA dehydrogenase activity
PXO_RS14565	COG3250	beta-galactosidase activity
PXO_RS14610	COG2353	YceI-like domain
PXO_RS14620	COG2353	YceI-like domain
PXO_RS14630	COG1760	l-serine dehydratase
PXO_RS14640	COG0626	cystathionine gamma-synthase activity
PXO_RS14645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PXO_RS14650	COG0739	heme binding
PXO_RS14655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PXO_RS14660	COG1272	protein, Hemolysin III
PXO_RS14675	COG0516	GMP reductase activity
PXO_RS14675	COG0517	IMP dehydrogenase activity
PXO_RS14680	COG0463	Glycosyl transferase, family 2
PXO_RS14690	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PXO_RS14700	COG4771	TonB-dependent receptor
PXO_RS14705	COG1309	transcriptional regulator
PXO_RS14715	COG1960	acyl-CoA dehydrogenase activity
PXO_RS14740	COG0509	glycine decarboxylation via glycine cleavage system
PXO_RS14745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PXO_RS14755	COG0330	HflC and HflK could
PXO_RS14765	COG3956	TIGRFAM MazG family protein
PXO_RS14775	COG0494	nUDIX hydrolase
PXO_RS14785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PXO_RS14790	COG0837	glucose binding
PXO_RS14805	COG1388	LysM domain
PXO_RS14805	COG3858	chitin binding
PXO_RS14810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PXO_RS14820	COG1472	Belongs to the glycosyl hydrolase 3 family
PXO_RS14865	COG3537	Alpha-1,2-mannosidase
PXO_RS14910	COG1446	asparaginase
PXO_RS14920	COG2304	oxidoreductase activity
PXO_RS14955	COG0643	Histidine kinase
PXO_RS14955	COG2198	Histidine kinase
PXO_RS14955	COG0784	Response regulator, receiver
PXO_RS14960	COG0840	transmembrane signaling receptor activity
PXO_RS14965	COG0835	chemotaxis
PXO_RS14980	COG0189	ligase activity
PXO_RS14990	COG1397	ADP-ribosylglycohydrolase
PXO_RS15000	COG1199	ATP-dependent helicase activity
PXO_RS15010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PXO_RS15015	COG1215	transferase activity, transferring glycosyl groups
PXO_RS15025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PXO_RS15035	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PXO_RS15040	COG0535	radical SAM domain protein
PXO_RS15045	COG0535	radical SAM domain protein
PXO_RS15060	COG0837	glucose binding
PXO_RS15080	COG1643	Atp-dependent helicase
PXO_RS15085	COG0783	Belongs to the Dps family
PXO_RS15090	COG0514	ATP-dependent DNA helicase (RecQ)
PXO_RS15110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PXO_RS15120	COG3293	Transposase
PXO_RS15135	COG0602	queuosine metabolic process
PXO_RS15145	COG2885	chlorophyll binding
PXO_RS15150	COG0823	Involved in the tonB-independent uptake of proteins
PXO_RS15160	COG0848	biopolymer transport protein
PXO_RS15170	COG0824	Thioesterase
PXO_RS15175	COG2255	four-way junction helicase activity
PXO_RS15185	COG0632	four-way junction helicase activity
PXO_RS15190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PXO_RS15195	COG0217	transcriptional regulatory protein
PXO_RS15210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PXO_RS15225	COG0477	Major facilitator Superfamily
PXO_RS15250	COG2963	transposase activity
PXO_RS15270	COG2963	transposase activity
PXO_RS15275	COG2801	Transposase and inactivated derivatives
PXO_RS15300	COG3293	Transposase
PXO_RS15345	COG0316	Belongs to the HesB IscA family
PXO_RS15345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PXO_RS15350	COG2154	pterin-4-alpha-carbinolamine dehydratase
PXO_RS15360	COG0428	transporter
PXO_RS15365	COG0428	transporter
PXO_RS15370	COG3064	Membrane
PXO_RS15380	COG1530	ribonuclease E activity
PXO_RS15390	COG3293	Transposase
PXO_RS15400	COG1054	Belongs to the UPF0176 family
PXO_RS15420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PXO_RS15445	COG3293	Transposase
PXO_RS15475	COG3039	Transposase
PXO_RS15520	COG1648	precorrin-2 dehydrogenase activity
PXO_RS15520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PXO_RS15545	COG0746	molybdenum cofactor guanylyltransferase activity
PXO_RS15590	COG3328	transposase activity
PXO_RS15595	COG4206	TonB-dependent receptor
PXO_RS15615	COG4206	TonB-dependent receptor
PXO_RS15665	COG0531	amino acid
PXO_RS15680	COG0006	proline dipeptidase activity
PXO_RS15690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PXO_RS15705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PXO_RS15710	COG3938	Belongs to the proline racemase family
PXO_RS15720	COG0552	protein localization to endoplasmic reticulum
PXO_RS15740	COG0784	Response regulator, receiver
PXO_RS15740	COG4191	Histidine kinase
PXO_RS15760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PXO_RS15870	COG0438	transferase activity, transferring glycosyl groups
PXO_RS15880	COG0438	transferase activity, transferring glycosyl groups
PXO_RS15885	COG0438	transferase activity, transferring glycosyl groups
PXO_RS15940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PXO_RS15945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PXO_RS15955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PXO_RS15970	COG2963	transposase activity
PXO_RS15995	COG0556	nucleotide-excision repair
PXO_RS16000	COG4969	Belongs to the N-Me-Phe pilin family
PXO_RS16015	COG3039	Transposase
PXO_RS16055	COG4695	Portal protein
PXO_RS16100	COG3179	chitinase
PXO_RS16305	COG1611	Belongs to the LOG family
PXO_RS16315	COG2095	MarC family integral membrane protein
PXO_RS16325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PXO_RS16360	COG1185	polyribonucleotide nucleotidyltransferase activity
PXO_RS16365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PXO_RS16380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PXO_RS16385	COG0195	Participates in both transcription termination and antitermination
PXO_RS16390	COG0779	Required for maturation of 30S ribosomal subunits
PXO_RS16400	COG1007	ATP synthesis coupled electron transport
PXO_RS16430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PXO_RS16435	COG1034	ATP synthesis coupled electron transport
PXO_RS16440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PXO_RS16445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PXO_RS16450	COG0649	NAD binding
PXO_RS16455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PXO_RS16465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PXO_RS16480	COG0149	triose-phosphate isomerase activity
PXO_RS16500	COG3293	Transposase
PXO_RS16530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PXO_RS16535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PXO_RS16545	COG0159	tryptophan synthase activity
PXO_RS16555	COG0133	tryptophan synthase activity
PXO_RS16565	COG0135	phosphoribosylanthranilate isomerase activity
PXO_RS16570	COG0101	tRNA pseudouridine synthase activity
PXO_RS16585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PXO_RS16590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PXO_RS16595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PXO_RS16600	COG2890	protein-(glutamine-N5) methyltransferase activity
PXO_RS16620	COG0433	COG0433 Predicted ATPase
PXO_RS16625	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS16650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PXO_RS16660	COG0412	Dienelactone hydrolase
PXO_RS16680	COG0717	Belongs to the dCTP deaminase family
PXO_RS16685	COG0489	protein tyrosine kinase activity
PXO_RS16720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PXO_RS16725	COG2311	Membrane
PXO_RS16730	COG1047	Peptidyl-prolyl cis-trans
PXO_RS16735	COG0791	NLP P60 protein
PXO_RS16740	COG0791	NLP P60 protein
PXO_RS16755	COG1301	dicarboxylic acid transport
PXO_RS16760	COG1785	Belongs to the alkaline phosphatase family
PXO_RS16765	COG0037	tRNA processing
PXO_RS16770	COG1722	exodeoxyribonuclease VII activity
PXO_RS16775	COG0142	geranyltranstransferase activity
PXO_RS16795	COG0312	modulator of DNA gyrase
PXO_RS16800	COG3028	Belongs to the UPF0307 family
PXO_RS16805	COG0312	modulator of DNA gyrase
PXO_RS16815	COG3164	Protein of unknown function
PXO_RS16830	COG2968	Membrane
PXO_RS16855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PXO_RS16880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PXO_RS16895	COG0495	leucyl-tRNA aminoacylation
PXO_RS16905	COG3118	belongs to the thioredoxin family
PXO_RS16920	COG3293	Transposase
PXO_RS16960	COG3039	Transposase
PXO_RS16970	COG3293	Transposase
PXO_RS16985	COG3039	Transposase
PXO_RS17005	COG3293	Transposase
PXO_RS17010	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS17040	COG2801	Transposase and inactivated derivatives
PXO_RS17045	COG2963	transposase activity
PXO_RS17080	COG2022	thiamine diphosphate biosynthetic process
PXO_RS17090	COG0471	metal ion transport
PXO_RS17090	COG3273	potassium ion transport
PXO_RS17115	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS17125	COG1970	mechanosensitive ion channel activity
PXO_RS17135	COG3293	Transposase
PXO_RS17145	COG2272	Belongs to the type-B carboxylesterase lipase family
PXO_RS17150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PXO_RS17180	COG0308	aminopeptidase N
PXO_RS17185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PXO_RS17195	COG3039	Transposase
PXO_RS17205	COG2895	sulfate adenylyltransferase (ATP) activity
PXO_RS17205	COG0529	Catalyzes the synthesis of activated sulfate
PXO_RS17210	COG0175	sulfate reduction
PXO_RS17215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PXO_RS17220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PXO_RS17225	COG0175	sulfate reduction
PXO_RS17245	COG2205	protein histidine kinase activity
PXO_RS17245	COG2198	Histidine kinase
PXO_RS17245	COG0784	Response regulator, receiver
PXO_RS17275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PXO_RS17280	COG3588	fructose-bisphosphate aldolase
PXO_RS17285	COG0469	pyruvate kinase activity
PXO_RS17295	COG0126	phosphoglycerate kinase activity
PXO_RS17325	COG0753	catalase activity
PXO_RS17340	COG1917	Cupin 2, conserved barrel domain protein
PXO_RS17340	COG2207	Transcriptional regulator
PXO_RS17365	COG0823	Involved in the tonB-independent uptake of proteins
PXO_RS17365	COG1506	peptidase
PXO_RS17380	COG1297	OPT oligopeptide transporter protein
PXO_RS17395	COG0587	DNA-directed DNA polymerase activity
PXO_RS17525	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
PXO_RS17655	COG3179	chitinase
PXO_RS17715	COG1741	Belongs to the pirin family
PXO_RS17720	COG1966	Carbon starvation protein
PXO_RS17725	COG2879	small protein
PXO_RS17755	COG3321	synthase
PXO_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS17755	COG0604	alcohol dehydrogenase
PXO_RS17760	COG2203	Gaf domain
PXO_RS17760	COG3706	GGDEF domain
PXO_RS17760	COG5001	Diguanylate cyclase
PXO_RS17760	COG4251	negative regulation of phosphorylation
PXO_RS17770	COG0629	single-stranded DNA binding
PXO_RS17775	COG0142	geranyltranstransferase activity
PXO_RS17805	COG0527	aspartate kinase activity
PXO_RS17815	COG0384	phenazine biosynthesis protein PhzF
PXO_RS17825	COG1764	response to oxidative stress
PXO_RS17835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PXO_RS17840	COG1678	Uncharacterized ACR, COG1678
PXO_RS17855	COG0519	Catalyzes the synthesis of GMP from XMP
PXO_RS17880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PXO_RS17920	COG0693	protein deglycase activity
PXO_RS17935	COG1959	2 iron, 2 sulfur cluster binding
PXO_RS17940	COG0719	Fe-S assembly protein
PXO_RS17945	COG0396	ATPase activity
PXO_RS17950	COG0719	Fe-S assembly protein
PXO_RS17955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PXO_RS17965	COG2146	nitrite reductase [NAD(P)H] activity
PXO_RS17970	COG3039	Transposase
PXO_RS17975	COG2963	transposase activity
PXO_RS18015	COG3328	transposase activity
PXO_RS18025	COG2963	transposase activity
PXO_RS18045	COG0326	Molecular chaperone. Has ATPase activity
PXO_RS18050	COG2207	Transcriptional regulator
PXO_RS18070	COG2755	lipolytic protein G-D-S-L family
PXO_RS18070	COG0657	acetylesterase activity
PXO_RS18090	COG0488	(ABC) transporter
PXO_RS18120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PXO_RS18120	COG4651	solute:proton antiporter activity
PXO_RS18125	COG2801	Transposase and inactivated derivatives
PXO_RS18140	COG4772	TonB-dependent receptor
PXO_RS18150	COG4264	IucA IucC family
PXO_RS18155	COG2814	Major facilitator Superfamily
PXO_RS18165	COG0019	diaminopimelate decarboxylase activity
PXO_RS18180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PXO_RS18215	COG4206	TonB-dependent receptor
PXO_RS18230	COG2963	transposase activity
PXO_RS18245	COG0542	response to heat
PXO_RS18275	COG0534	Mate efflux family protein
PXO_RS18285	COG0336	Belongs to the RNA methyltransferase TrmD family
PXO_RS18290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PXO_RS18295	COG0228	four-way junction DNA binding
PXO_RS18315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PXO_RS18330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PXO_RS18385	COG1555	photosystem II stabilization
PXO_RS18390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PXO_RS18405	COG3178	'Phosphotransferase
PXO_RS18410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PXO_RS18420	COG0628	permease
PXO_RS18430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PXO_RS18445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PXO_RS18465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PXO_RS18470	COG0271	Belongs to the BolA IbaG family
PXO_RS18480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PXO_RS18490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PXO_RS18495	COG1137	ATPase activity
PXO_RS18510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PXO_RS18515	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PXO_RS18520	COG1660	Displays ATPase and GTPase activities
PXO_RS18530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PXO_RS18535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PXO_RS18540	COG2239	Acts as a magnesium transporter
PXO_RS18550	COG1294	oxidase, subunit
PXO_RS18555	COG1271	oxidase subunit
PXO_RS18565	COG1113	amino acid transport
PXO_RS18575	COG2197	response regulator
PXO_RS18580	COG0531	amino acid
PXO_RS18655	COG0754	glutathionylspermidine amidase activity
PXO_RS18680	COG1842	Phage shock protein A
PXO_RS18695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PXO_RS18700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PXO_RS18710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PXO_RS18745	COG2201	protein-glutamate methylesterase activity
PXO_RS18790	COG2201	protein-glutamate methylesterase activity
PXO_RS18815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PXO_RS18835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PXO_RS18870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PXO_RS18875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PXO_RS18910	COG3039	Transposase
PXO_RS18925	COG0745	RESPONSE REGULATOR receiver
PXO_RS18930	COG3039	Transposase
PXO_RS18935	COG2205	protein histidine kinase activity
PXO_RS18950	COG3293	Transposase
PXO_RS18955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PXO_RS18995	COG3453	Protein conserved in bacteria
PXO_RS18995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PXO_RS19000	COG0725	ABC transporter, periplasmic molybdate-binding protein
PXO_RS19005	COG4149	molybdate abc transporter
PXO_RS19010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PXO_RS19030	COG0642	Histidine kinase
PXO_RS19045	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS19055	COG1022	Amp-dependent synthetase and ligase
PXO_RS19080	COG1376	ErfK ybiS ycfS ynhG family protein
PXO_RS19085	COG0739	heme binding
PXO_RS19090	COG4773	Receptor
PXO_RS19095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PXO_RS19100	COG1301	dicarboxylic acid transport
PXO_RS19115	COG2304	oxidoreductase activity
PXO_RS19135	COG0714	Associated with various cellular activities
PXO_RS19170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PXO_RS19195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PXO_RS19205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PXO_RS19225	COG1561	YicC-like family, N-terminal region
PXO_RS19230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PXO_RS19245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PXO_RS19270	COG0006	proline dipeptidase activity
PXO_RS19290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PXO_RS19300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PXO_RS19310	COG2912	Transglutaminase-like superfamily
PXO_RS19315	COG1773	rubredoxin
PXO_RS19320	COG0352	thiamine-phosphate diphosphorylase activity
PXO_RS19340	COG2801	Transposase and inactivated derivatives
PXO_RS19345	COG2963	transposase activity
PXO_RS19355	COG0281	malic enzyme
PXO_RS19355	COG0280	phosphate acetyltransferase
PXO_RS19370	COG4191	Histidine kinase
PXO_RS19385	COG0583	DNA-binding transcription factor activity
PXO_RS19400	COG2197	response regulator
PXO_RS19410	COG0642	Histidine kinase
PXO_RS19425	COG2851	Citrate transporter
PXO_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS19435	COG1609	Transcriptional regulator
PXO_RS19440	COG2211	Major facilitator Superfamily
PXO_RS19465	COG1162	GTPase activity
PXO_RS19485	COG0726	polysaccharide deacetylase
PXO_RS19490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PXO_RS19525	COG0242	peptide deformylase activity
PXO_RS19545	COG0714	Associated with various cellular activities
PXO_RS19565	COG0537	adenosine 5'-monophosphoramidase activity
PXO_RS19590	COG0314	molybdopterin synthase activity
PXO_RS19595	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PXO_RS19600	COG0315	cyclic pyranopterin monophosphate synthase activity
PXO_RS19610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PXO_RS19615	COG1234	tRNA 3'-trailer cleavage
PXO_RS19620	COG3642	lipopolysaccharide core region biosynthetic process
PXO_RS19625	COG0859	PFAM glycosyl transferase family 9
PXO_RS19635	COG0582	viral genome integration into host DNA
PXO_RS19710	COG0631	protein serine/threonine phosphatase activity
PXO_RS19740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PXO_RS19770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PXO_RS19780	COG0544	peptidyl-prolyl cis-trans isomerase activity
PXO_RS19805	COG2963	transposase activity
PXO_RS19835	COG0473	3-isopropylmalate dehydrogenase activity
PXO_RS19865	COG4783	chaperone-mediated protein folding
PXO_RS19880	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PXO_RS19890	COG0438	transferase activity, transferring glycosyl groups
PXO_RS19895	COG0671	phosphoesterase, PA-phosphatase related
PXO_RS19900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PXO_RS19910	COG2833	Protein of unknown function (DUF455)
PXO_RS19930	COG0285	dihydrofolate synthase activity
PXO_RS19935	COG0406	alpha-ribazole phosphatase activity
PXO_RS19965	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PXO_RS19970	COG4208	sulfate ABC transporter
PXO_RS19975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PXO_RS19980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PXO_RS19985	COG0156	8-amino-7-oxononanoate synthase activity
PXO_RS20010	COG0604	alcohol dehydrogenase
PXO_RS20015	COG0446	pyridine nucleotide-disulphide oxidoreductase
PXO_RS20015	COG1902	pentaerythritol trinitrate reductase activity
PXO_RS20025	COG2963	transposase activity
PXO_RS20055	COG0584	glycerophosphoryl diester phosphodiesterase
PXO_RS20060	COG3293	Transposase
PXO_RS20085	COG3039	Transposase
PXO_RS20100	COG0625	glutathione transferase activity
PXO_RS20105	COG0039	L-malate dehydrogenase activity
PXO_RS20110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PXO_RS20115	COG1217	gtp-binding protein TYPA
PXO_RS20135	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PXO_RS20155	COG2963	transposase activity
PXO_RS20205	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS20225	COG2963	transposase activity
PXO_RS20250	COG3293	Transposase
PXO_RS20275	COG3293	Transposase
PXO_RS20300	COG3781	membrane
PXO_RS20310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PXO_RS20350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PXO_RS20370	COG3710	Transcriptional regulator
PXO_RS20375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PXO_RS20380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PXO_RS20410	COG2226	methyltransferase
PXO_RS20415	COG0066	3-isopropylmalate dehydratase activity
PXO_RS20420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PXO_RS20455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PXO_RS20460	COG1538	Outer membrane efflux protein
PXO_RS20465	COG1519	Transferase
PXO_RS20470	COG1560	Kdo2-lipid A biosynthetic process
PXO_RS20510	COG0308	aminopeptidase N
PXO_RS20515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PXO_RS20525	COG0330	HflC and HflK could
PXO_RS20530	COG0330	HflC and HflK could
PXO_RS20550	COG0678	peroxiredoxin activity
PXO_RS20560	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS20640	COG3829	transcription factor binding
PXO_RS20665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PXO_RS20670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PXO_RS20680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PXO_RS20685	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS20710	COG1399	metal-binding, possibly nucleic acid-binding protein
PXO_RS20750	COG1518	maintenance of DNA repeat elements
PXO_RS20755	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PXO_RS20790	COG2188	Transcriptional regulator
PXO_RS20800	COG1450	Type ii and iii secretion system protein
PXO_RS20815	COG3166	PFAM Fimbrial assembly family protein
PXO_RS20820	COG3156	type II secretion system protein K
PXO_RS20825	COG4795	General secretion pathway protein
PXO_RS20830	COG2165	general secretion pathway protein
PXO_RS20835	COG4970	Tfp pilus assembly protein FimT
PXO_RS20840	COG2165	general secretion pathway protein
PXO_RS20845	COG1459	type II secretion system
PXO_RS20855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PXO_RS20865	COG5295	Hep Hag repeat protein
PXO_RS20870	COG0047	phosphoribosylformylglycinamidine synthase activity
PXO_RS20870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PXO_RS20875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PXO_RS20880	COG4974	Belongs to the 'phage' integrase family
PXO_RS20895	COG0795	lipopolysaccharide-transporting ATPase activity
PXO_RS20905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PXO_RS20920	COG0525	valine-tRNA ligase activity
PXO_RS20930	COG2963	transposase activity
PXO_RS20935	COG2801	Transposase and inactivated derivatives
PXO_RS20945	COG3039	Transposase
PXO_RS20965	COG3039	Transposase
PXO_RS20990	COG1183	phosphatidylcholine synthase activity
PXO_RS21000	COG0442	prolyl-tRNA aminoacylation
PXO_RS21015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PXO_RS21020	COG1127	ABC transporter
PXO_RS21025	COG3218	ABC-type transport auxiliary lipoprotein component
PXO_RS21025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PXO_RS21060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PXO_RS21065	COG0662	Cupin 2, conserved barrel domain protein
PXO_RS21065	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PXO_RS21090	COG2086	electron transfer activity
PXO_RS21115	COG3328	transposase activity
PXO_RS21155	COG0626	cystathionine gamma-synthase activity
PXO_RS21185	COG0625	glutathione transferase activity
PXO_RS21195	COG0513	Belongs to the DEAD box helicase family
PXO_RS21205	COG0720	synthase
PXO_RS21215	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PXO_RS21220	COG1956	GAF domain-containing protein
PXO_RS21255	COG0339	signal peptide processing
PXO_RS21290	COG3293	Transposase
PXO_RS21305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PXO_RS21310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PXO_RS21315	COG3842	ATPase activity
PXO_RS21365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PXO_RS21370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PXO_RS21375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PXO_RS21380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PXO_RS21385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PXO_RS21390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PXO_RS21400	COG0356	it plays a direct role in the translocation of protons across the membrane
PXO_RS21420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PXO_RS21430	COG0508	dehydrogenase complex catalyzes the overall conversion of
PXO_RS21460	COG2011	ABC-type metal ion transport system permease component
PXO_RS21470	COG0697	spore germination
PXO_RS21505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PXO_RS21510	COG1187	pseudouridine synthase activity
PXO_RS21515	COG2813	Specifically methylates the guanine in position
PXO_RS21535	COG2205	protein histidine kinase activity
PXO_RS21535	COG2202	Pas domain
PXO_RS21560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PXO_RS21605	COG0745	RESPONSE REGULATOR receiver
PXO_RS21620	COG1404	Belongs to the peptidase S8 family
PXO_RS21640	COG0842	Transport permease protein
PXO_RS21645	COG1131	(ABC) transporter
PXO_RS21650	COG0025	NhaP-type Na H and K H
PXO_RS21665	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PXO_RS21670	COG1573	uracil-dna glycosylase
PXO_RS21680	COG3384	dioxygenase
PXO_RS21695	COG0667	Aldo Keto reductase
PXO_RS21710	COG3590	peptidase
PXO_RS21725	COG0531	amino acid
PXO_RS21735	COG3279	Response regulator of the LytR AlgR family
PXO_RS21740	COG3279	Response regulator of the LytR AlgR family
PXO_RS21775	COG2963	transposase activity
PXO_RS21805	COG1271	oxidase subunit
PXO_RS21820	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS21840	COG1324	tolerance protein
PXO_RS21855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PXO_RS21860	COG0511	ligase activity, forming carbon-carbon bonds
PXO_RS21870	COG0439	Biotin carboxylase
PXO_RS21905	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PXO_RS21930	COG2801	Transposase and inactivated derivatives
PXO_RS21935	COG2963	transposase activity
PXO_RS21975	COG3039	Transposase
PXO_RS22000	COG2963	transposase activity
PXO_RS22015	COG3210	domain, Protein
PXO_RS22020	COG2831	hemolysin activation secretion protein
PXO_RS22040	COG2453	phosphatase
PXO_RS22040	COG0671	phosphoesterase, PA-phosphatase related
PXO_RS22045	COG2267	carboxylic ester hydrolase activity
PXO_RS22055	COG2267	carboxylic ester hydrolase activity
PXO_RS22060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PXO_RS22065	COG0138	bifunctional purine biosynthesis protein purh
PXO_RS22070	COG0151	Belongs to the GarS family
PXO_RS22075	COG0577	efflux transmembrane transporter activity
PXO_RS22075	COG1136	(ABC) transporter
PXO_RS22085	COG1289	transmembrane transporter activity
PXO_RS22100	COG2814	Major facilitator Superfamily
PXO_RS22120	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PXO_RS22160	COG0745	RESPONSE REGULATOR receiver
PXO_RS22170	COG2963	transposase activity
PXO_RS22175	COG2801	Transposase and inactivated derivatives
PXO_RS22210	COG0739	heme binding
PXO_RS22225	COG2211	Major facilitator Superfamily
PXO_RS22230	COG0708	Exodeoxyribonuclease III
PXO_RS22245	COG1192	Involved in chromosome partitioning
PXO_RS22250	COG1475	DNA binding
PXO_RS22265	COG0463	Glycosyl transferase, family 2
PXO_RS22285	COG0756	dUTP diphosphatase activity
PXO_RS22290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PXO_RS22295	COG2003	Belongs to the UPF0758 family
PXO_RS22300	COG0018	arginyl-trna synthetase
PXO_RS22315	COG4221	oxidoreductase activity
PXO_RS22320	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS22330	COG1414	Transcriptional regulator
PXO_RS22340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PXO_RS22345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PXO_RS22355	COG3485	protocatechuate 3,4-dioxygenase
PXO_RS22360	COG3485	protocatechuate 3,4-dioxygenase
PXO_RS22380	COG2963	transposase activity
PXO_RS22405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PXO_RS22410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PXO_RS22420	COG0045	succinate-CoA ligase (ADP-forming) activity
PXO_RS22420	COG1042	CoA-binding domain protein
PXO_RS22420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PXO_RS22430	COG2239	Acts as a magnesium transporter
PXO_RS22445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PXO_RS22450	COG3387	PFAM Glycoside hydrolase 15-related
PXO_RS22465	COG3100	YcgL domain-containing protein
PXO_RS22470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PXO_RS22480	COG0463	Glycosyl transferase, family 2
PXO_RS22495	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS22505	COG0156	8-amino-7-oxononanoate synthase activity
PXO_RS22510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PXO_RS22515	COG1040	competence protein
PXO_RS22520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PXO_RS22530	COG0628	permease
PXO_RS22540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PXO_RS22550	COG1595	DNA-templated transcription, initiation
PXO_RS22555	COG0753	catalase activity
PXO_RS22600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PXO_RS22605	COG0180	Tryptophanyl-tRNA synthetase
PXO_RS22610	COG3237	CsbD-like
PXO_RS22645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PXO_RS22660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PXO_RS22665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PXO_RS22665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PXO_RS22705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PXO_RS22730	COG1566	PFAM secretion protein HlyD family protein
PXO_RS22750	COG1199	ATP-dependent helicase activity
PXO_RS22780	COG0583	DNA-binding transcription factor activity
PXO_RS22815	COG0625	glutathione transferase activity
PXO_RS22850	COG4555	ABC transporter
PXO_RS22860	COG1476	TRANSCRIPTIONal
PXO_RS22880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PXO_RS22885	COG1131	(ABC) transporter
PXO_RS22890	COG0842	Transport permease protein
PXO_RS22900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PXO_RS22940	COG2963	transposase activity
PXO_RS22945	COG3293	Transposase
PXO_RS22975	COG1181	Belongs to the D-alanine--D-alanine ligase family
PXO_RS22990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PXO_RS23000	COG0564	pseudouridine synthase activity
PXO_RS23025	COG0339	signal peptide processing
PXO_RS23050	COG3254	rhamnose metabolic process
PXO_RS23055	COG0738	Major facilitator superfamily
PXO_RS23060	COG1414	Transcriptional regulator
PXO_RS23070	COG3293	Transposase
PXO_RS23080	COG2205	protein histidine kinase activity
PXO_RS23095	COG3459	Glycosyltransferase 36 associated
PXO_RS23100	COG2211	Major facilitator Superfamily
PXO_RS23105	COG3265	gluconokinase activity
PXO_RS23110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PXO_RS23130	COG2963	transposase activity
PXO_RS23135	COG2801	Transposase and inactivated derivatives
PXO_RS23190	COG1127	ABC transporter
PXO_RS23195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PXO_RS23200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PXO_RS23215	COG2853	Lipoprotein
PXO_RS23235	COG3293	Transposase
PXO_RS23250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PXO_RS23260	COG2963	transposase activity
PXO_RS23265	COG2801	Transposase and inactivated derivatives
PXO_RS23295	COG3135	benzoate transporter
PXO_RS23300	COG3135	benzoate transporter
PXO_RS23320	COG0676	glucose-6-phosphate 1-epimerase activity
PXO_RS23340	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS23345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PXO_RS23350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PXO_RS23355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PXO_RS23360	COG1064	alcohol dehydrogenase
PXO_RS23395	COG2826	transposase and inactivated derivatives, IS30 family
PXO_RS23400	COG4773	Receptor
PXO_RS23415	COG1522	sequence-specific DNA binding
PXO_RS23420	COG3186	Phenylalanine-4-hydroxylase
PXO_RS23430	COG2755	lipolytic protein G-D-S-L family
PXO_RS23445	COG2963	transposase activity
PXO_RS23460	COG0656	L-ascorbic acid biosynthetic process
PXO_RS23465	COG2130	NADP-dependent
PXO_RS23470	COG0667	Aldo Keto reductase
PXO_RS23480	COG1187	pseudouridine synthase activity
PXO_RS23495	COG1643	Atp-dependent helicase
PXO_RS23500	COG4807	Protein conserved in bacteria
PXO_RS23505	COG4948	Mandelate Racemase Muconate Lactonizing
PXO_RS23510	COG0179	Fumarylacetoacetate (FAA) hydrolase
PXO_RS23515	COG1028	Short-chain dehydrogenase reductase Sdr
PXO_RS23535	COG3507	Belongs to the glycosyl hydrolase 43 family
PXO_RS23575	COG3162	membrane
PXO_RS23580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PXO_RS23590	COG0708	Exodeoxyribonuclease III
PXO_RS23605	COG2091	lysine biosynthetic process via aminoadipic acid
PXO_RS23615	COG3540	Alkaline phosphatase
PXO_RS23620	COG0357	Ribosomal RNA small subunit methyltransferase G
PXO_RS23640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PXO_RS23645	COG2159	amidohydrolase
PXO_RS23660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PXO_RS23665	COG0583	DNA-binding transcription factor activity
PXO_RS23670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PXO_RS23685	COG0210	DNA helicase
PXO_RS23700	COG0531	amino acid
PXO_RS23705	COG1322	Protein conserved in bacteria
PXO_RS23715	COG0386	Belongs to the glutathione peroxidase family
PXO_RS23765	COG0793	Belongs to the peptidase S41A family
PXO_RS23770	COG4942	peptidase
PXO_RS23780	COG2234	aminopeptidase activity
PXO_RS23825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PXO_RS23830	COG0302	gtp cyclohydrolase
PXO_RS23850	COG0477	Major facilitator Superfamily
PXO_RS23865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PXO_RS23965	COG1929	Belongs to the glycerate kinase type-1 family
PXO_RS23970	COG2271	Major facilitator Superfamily
PXO_RS23985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PXO_RS23990	COG0861	Integral membrane protein TerC family
PXO_RS24000	COG0584	glycerophosphoryl diester phosphodiesterase
PXO_RS24010	COG0671	phosphoesterase, PA-phosphatase related
PXO_RS24015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PXO_RS24020	COG0726	polysaccharide deacetylase
PXO_RS24025	COG0706	membrane insertase activity
PXO_RS24045	COG1116	anion transmembrane transporter activity