locus-tag	class	description
LA08_RS00025	COG0187	DNA topoisomerase II activity
LA08_RS00035	COG0501	Belongs to the peptidase M48B family
LA08_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA08_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LA08_RS00095	COG4772	TonB-dependent receptor
LA08_RS00110	COG3039	Transposase
LA08_RS00115	COG1304	FMN binding
LA08_RS00120	COG1755	Isoprenylcysteine carboxyl methyltransferase
LA08_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA08_RS00155	COG3039	Transposase
LA08_RS00160	COG1136	(ABC) transporter
LA08_RS00210	COG3039	Transposase
LA08_RS00220	COG0513	Belongs to the DEAD box helicase family
LA08_RS00325	COG1858	cytochrome C peroxidase
LA08_RS00335	COG0702	epimerase
LA08_RS00360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LA08_RS00380	COG1649	PFAM Uncharacterised BCR, COG1649
LA08_RS00385	COG2354	Protein conserved in bacteria
LA08_RS00395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LA08_RS00410	COG1511	domain protein
LA08_RS00410	COG3264	Mechanosensitive ion channel
LA08_RS00490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LA08_RS00570	COG3039	Transposase
LA08_RS00580	COG3039	Transposase
LA08_RS00615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA08_RS00625	COG0642	Histidine kinase
LA08_RS00635	COG1090	epimerase
LA08_RS00645	COG3039	Transposase
LA08_RS00670	COG2826	transposase and inactivated derivatives, IS30 family
LA08_RS00730	COG1136	(ABC) transporter
LA08_RS00775	COG1272	protein, Hemolysin III
LA08_RS00780	COG1205	dead DEAH box helicase
LA08_RS00780	COG1111	helicase
LA08_RS00845	COG0067	glutamate synthase
LA08_RS00845	COG0069	glutamate synthase activity
LA08_RS00845	COG0070	glutamate synthase
LA08_RS00850	COG0493	'glutamate synthase
LA08_RS00900	COG1609	Transcriptional regulator
LA08_RS00935	COG0366	Alpha amylase catalytic
LA08_RS00940	COG0366	Alpha amylase catalytic
LA08_RS00995	COG0606	chelatase, subunit chli
LA08_RS01040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LA08_RS01045	COG1166	arginine decarboxylase activity
LA08_RS01110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LA08_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS01160	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LA08_RS01175	COG0210	DNA helicase
LA08_RS01190	COG3132	Protein of unknown function, DUF480
LA08_RS01195	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LA08_RS01200	COG0284	orotidine-5'-phosphate decarboxylase activity
LA08_RS01235	COG2937	Belongs to the GPAT DAPAT family
LA08_RS01265	COG2755	lipolytic protein G-D-S-L family
LA08_RS01280	COG3186	Phenylalanine-4-hydroxylase
LA08_RS01285	COG1522	sequence-specific DNA binding
LA08_RS01335	COG1064	alcohol dehydrogenase
LA08_RS01345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LA08_RS01355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LA08_RS01365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LA08_RS01390	COG3039	Transposase
LA08_RS01395	COG0676	glucose-6-phosphate 1-epimerase activity
LA08_RS01460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LA08_RS01485	COG2853	Lipoprotein
LA08_RS01500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA08_RS01505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA08_RS01510	COG1127	ABC transporter
LA08_RS01585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA08_RS01600	COG3265	gluconokinase activity
LA08_RS01605	COG2211	Major facilitator Superfamily
LA08_RS01610	COG3459	Glycosyltransferase 36 associated
LA08_RS01625	COG2205	protein histidine kinase activity
LA08_RS01635	COG1414	Transcriptional regulator
LA08_RS01640	COG0738	Major facilitator superfamily
LA08_RS01645	COG3254	rhamnose metabolic process
LA08_RS01675	COG0339	signal peptide processing
LA08_RS01705	COG0564	pseudouridine synthase activity
LA08_RS01715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LA08_RS01815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LA08_RS01825	COG0842	Transport permease protein
LA08_RS01830	COG1131	(ABC) transporter
LA08_RS01835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA08_RS01855	COG1476	TRANSCRIPTIONal
LA08_RS01865	COG4555	ABC transporter
LA08_RS01905	COG0625	glutathione transferase activity
LA08_RS01955	COG0583	DNA-binding transcription factor activity
LA08_RS01990	COG1199	ATP-dependent helicase activity
LA08_RS02010	COG1566	PFAM secretion protein HlyD family protein
LA08_RS02040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA08_RS02080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LA08_RS02080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LA08_RS02085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LA08_RS02100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LA08_RS02140	COG3237	CsbD-like
LA08_RS02145	COG0180	Tryptophanyl-tRNA synthetase
LA08_RS02150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA08_RS02200	COG0753	catalase activity
LA08_RS02205	COG1595	DNA-templated transcription, initiation
LA08_RS02215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LA08_RS02225	COG0628	permease
LA08_RS02240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LA08_RS02245	COG1040	competence protein
LA08_RS02250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LA08_RS02255	COG0156	8-amino-7-oxononanoate synthase activity
LA08_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS02285	COG0463	Glycosyl transferase, family 2
LA08_RS02295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LA08_RS02300	COG3100	YcgL domain-containing protein
LA08_RS02315	COG3387	PFAM Glycoside hydrolase 15-related
LA08_RS02325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA08_RS02345	COG2239	Acts as a magnesium transporter
LA08_RS02355	COG1042	CoA-binding domain protein
LA08_RS02355	COG0045	succinate-CoA ligase (ADP-forming) activity
LA08_RS02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA08_RS02365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA08_RS02375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA08_RS02410	COG3485	protocatechuate 3,4-dioxygenase
LA08_RS02415	COG3485	protocatechuate 3,4-dioxygenase
LA08_RS02430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA08_RS02435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LA08_RS02465	COG4221	oxidoreductase activity
LA08_RS02490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA08_RS02515	COG0463	Glycosyl transferase, family 2
LA08_RS02530	COG1475	DNA binding
LA08_RS02535	COG1192	Involved in chromosome partitioning
LA08_RS02550	COG0708	Exodeoxyribonuclease III
LA08_RS02555	COG2211	Major facilitator Superfamily
LA08_RS02570	COG0739	heme binding
LA08_RS02620	COG0745	RESPONSE REGULATOR receiver
LA08_RS02660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LA08_RS02685	COG2814	Major facilitator Superfamily
LA08_RS02700	COG1289	transmembrane transporter activity
LA08_RS02710	COG1136	(ABC) transporter
LA08_RS02710	COG0577	efflux transmembrane transporter activity
LA08_RS02715	COG0151	Belongs to the GarS family
LA08_RS02725	COG0419	ATPase involved in DNA repair
LA08_RS02740	COG2267	carboxylic ester hydrolase activity
LA08_RS02750	COG2267	carboxylic ester hydrolase activity
LA08_RS02755	COG0671	phosphoesterase, PA-phosphatase related
LA08_RS02755	COG2453	phosphatase
LA08_RS02770	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LA08_RS02830	COG0439	Biotin carboxylase
LA08_RS02840	COG0511	ligase activity, forming carbon-carbon bonds
LA08_RS02845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LA08_RS02865	COG1324	tolerance protein
LA08_RS02900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA08_RS02930	COG0534	Mate efflux family protein
LA08_RS02935	COG0616	signal peptide processing
LA08_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS02960	COG0009	L-threonylcarbamoyladenylate synthase
LA08_RS02965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA08_RS02965	COG1754	DNA topoisomerase type I activity
LA08_RS02980	COG2922	Belongs to the Smg family
LA08_RS02985	COG0758	DNA mediated transformation
LA08_RS02990	COG1652	LysM domain
LA08_RS02995	COG0242	peptide deformylase activity
LA08_RS03000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LA08_RS03005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA08_RS03005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA08_RS03055	COG1560	Kdo2-lipid A biosynthetic process
LA08_RS03065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA08_RS03220	COG1294	oxidase, subunit
LA08_RS03225	COG1271	oxidase subunit
LA08_RS03240	COG2204	response regulator
LA08_RS03270	COG2972	Histidine kinase
LA08_RS03285	COG0531	amino acid
LA08_RS03305	COG3590	peptidase
LA08_RS03320	COG0667	Aldo Keto reductase
LA08_RS03335	COG3384	dioxygenase
LA08_RS03345	COG1573	uracil-dna glycosylase
LA08_RS03355	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LA08_RS03370	COG0025	NhaP-type Na H and K H
LA08_RS03375	COG1131	(ABC) transporter
LA08_RS03380	COG0842	Transport permease protein
LA08_RS03395	COG1404	Belongs to the peptidase S8 family
LA08_RS03410	COG0745	RESPONSE REGULATOR receiver
LA08_RS03460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA08_RS03485	COG2202	Pas domain
LA08_RS03485	COG2205	protein histidine kinase activity
LA08_RS03520	COG2813	Specifically methylates the guanine in position
LA08_RS03525	COG1187	pseudouridine synthase activity
LA08_RS03530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA08_RS03565	COG0697	spore germination
LA08_RS03575	COG2011	ABC-type metal ion transport system permease component
LA08_RS03605	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA08_RS03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA08_RS03635	COG0356	it plays a direct role in the translocation of protons across the membrane
LA08_RS03645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LA08_RS03655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LA08_RS03660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LA08_RS03665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LA08_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA08_RS03730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LA08_RS03785	COG0339	signal peptide processing
LA08_RS03825	COG1956	GAF domain-containing protein
LA08_RS03830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LA08_RS03840	COG0720	synthase
LA08_RS03850	COG0513	Belongs to the DEAD box helicase family
LA08_RS03895	COG0626	cystathionine gamma-synthase activity
LA08_RS03945	COG3328	transposase activity
LA08_RS03970	COG2086	electron transfer activity
LA08_RS03995	COG0662	Cupin 2, conserved barrel domain protein
LA08_RS03995	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LA08_RS04000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA08_RS04040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA08_RS04040	COG3218	ABC-type transport auxiliary lipoprotein component
LA08_RS04045	COG1127	ABC transporter
LA08_RS04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA08_RS04065	COG0442	prolyl-tRNA aminoacylation
LA08_RS04075	COG1183	phosphatidylcholine synthase activity
LA08_RS04105	COG3039	Transposase
LA08_RS04175	COG0525	valine-tRNA ligase activity
LA08_RS04190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LA08_RS04200	COG0795	lipopolysaccharide-transporting ATPase activity
LA08_RS04215	COG4974	Belongs to the 'phage' integrase family
LA08_RS04220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA08_RS04225	COG0047	phosphoribosylformylglycinamidine synthase activity
LA08_RS04225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LA08_RS04235	COG5295	Hep Hag repeat protein
LA08_RS04255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA08_RS04265	COG1459	type II secretion system
LA08_RS04270	COG2165	general secretion pathway protein
LA08_RS04275	COG4970	Tfp pilus assembly protein FimT
LA08_RS04280	COG2165	general secretion pathway protein
LA08_RS04285	COG4795	General secretion pathway protein
LA08_RS04290	COG3156	type II secretion system protein K
LA08_RS04295	COG3166	PFAM Fimbrial assembly family protein
LA08_RS04310	COG1450	Type ii and iii secretion system protein
LA08_RS04325	COG2188	Transcriptional regulator
LA08_RS04380	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LA08_RS04385	COG1518	maintenance of DNA repeat elements
LA08_RS04430	COG1399	metal-binding, possibly nucleic acid-binding protein
LA08_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS04460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA08_RS04470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA08_RS04475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA08_RS04510	COG3829	transcription factor binding
LA08_RS04545	COG3039	Transposase
LA08_RS04595	COG2826	transposase and inactivated derivatives, IS30 family
LA08_RS04605	COG0678	peroxiredoxin activity
LA08_RS04625	COG0330	HflC and HflK could
LA08_RS04630	COG0330	HflC and HflK could
LA08_RS04645	COG0308	aminopeptidase N
LA08_RS04695	COG1560	Kdo2-lipid A biosynthetic process
LA08_RS04700	COG1519	Transferase
LA08_RS04705	COG1538	Outer membrane efflux protein
LA08_RS04710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LA08_RS04735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LA08_RS04740	COG0066	3-isopropylmalate dehydratase activity
LA08_RS04775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LA08_RS04785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LA08_RS04790	COG3710	Transcriptional regulator
LA08_RS04815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LA08_RS04835	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LA08_RS04865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA08_RS04875	COG3781	membrane
LA08_RS04895	COG0625	glutathione transferase activity
LA08_RS04905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA08_RS04910	COG1217	gtp-binding protein TYPA
LA08_RS04930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LA08_RS05065	COG3039	Transposase
LA08_RS05090	COG0584	glycerophosphoryl diester phosphodiesterase
LA08_RS05115	COG0473	3-isopropylmalate dehydrogenase activity
LA08_RS05170	COG0544	peptidyl-prolyl cis-trans isomerase activity
LA08_RS05210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA08_RS05235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA08_RS05245	COG0631	protein serine/threonine phosphatase activity
LA08_RS05330	COG0582	viral genome integration into host DNA
LA08_RS05340	COG0859	PFAM glycosyl transferase family 9
LA08_RS05345	COG3642	lipopolysaccharide core region biosynthetic process
LA08_RS05350	COG1234	tRNA 3'-trailer cleavage
LA08_RS05355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LA08_RS05365	COG0315	cyclic pyranopterin monophosphate synthase activity
LA08_RS05370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LA08_RS05375	COG0314	molybdopterin synthase activity
LA08_RS05405	COG0537	adenosine 5'-monophosphoramidase activity
LA08_RS05425	COG0714	Associated with various cellular activities
LA08_RS05445	COG0242	peptide deformylase activity
LA08_RS05495	COG3039	Transposase
LA08_RS05525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA08_RS05530	COG0726	polysaccharide deacetylase
LA08_RS05580	COG2211	Major facilitator Superfamily
LA08_RS05590	COG1609	Transcriptional regulator
LA08_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS05600	COG2851	Citrate transporter
LA08_RS05620	COG0642	Histidine kinase
LA08_RS05630	COG2197	response regulator
LA08_RS05650	COG0583	DNA-binding transcription factor activity
LA08_RS05665	COG4191	Histidine kinase
LA08_RS05685	COG0280	phosphate acetyltransferase
LA08_RS05685	COG0281	malic enzyme
LA08_RS05720	COG0352	thiamine-phosphate diphosphorylase activity
LA08_RS05725	COG1773	rubredoxin
LA08_RS05730	COG2912	Transglutaminase-like superfamily
LA08_RS05750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LA08_RS05775	COG0006	proline dipeptidase activity
LA08_RS05810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA08_RS05825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LA08_RS05830	COG1561	YicC-like family, N-terminal region
LA08_RS05855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA08_RS05865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA08_RS05890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LA08_RS05940	COG0714	Associated with various cellular activities
LA08_RS05960	COG2304	oxidoreductase activity
LA08_RS05980	COG1301	dicarboxylic acid transport
LA08_RS05985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA08_RS05995	COG0739	heme binding
LA08_RS06000	COG1376	ErfK ybiS ycfS ynhG family protein
LA08_RS06025	COG1022	Amp-dependent synthetase and ligase
LA08_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS06050	COG0642	Histidine kinase
LA08_RS06070	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LA08_RS06075	COG4149	molybdate abc transporter
LA08_RS06080	COG0725	ABC transporter, periplasmic molybdate-binding protein
LA08_RS06085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA08_RS06085	COG3453	Protein conserved in bacteria
LA08_RS06120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA08_RS06140	COG2205	protein histidine kinase activity
LA08_RS06145	COG0745	RESPONSE REGULATOR receiver
LA08_RS06195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA08_RS06200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LA08_RS06290	COG2201	protein-glutamate methylesterase activity
LA08_RS06340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LA08_RS06355	COG1842	Phage shock protein A
LA08_RS06380	COG0754	glutathionylspermidine amidase activity
LA08_RS06450	COG0531	amino acid
LA08_RS06455	COG2197	response regulator
LA08_RS06470	COG1113	amino acid transport
LA08_RS06490	COG1271	oxidase subunit
LA08_RS06495	COG1294	oxidase, subunit
LA08_RS06505	COG2239	Acts as a magnesium transporter
LA08_RS06515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA08_RS06520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA08_RS06530	COG1660	Displays ATPase and GTPase activities
LA08_RS06535	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LA08_RS06540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA08_RS06555	COG1137	ATPase activity
LA08_RS06560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LA08_RS06570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LA08_RS06580	COG0271	Belongs to the BolA IbaG family
LA08_RS06590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LA08_RS06610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LA08_RS06625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LA08_RS06635	COG0628	permease
LA08_RS06645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LA08_RS06650	COG3178	'Phosphotransferase
LA08_RS06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LA08_RS06670	COG1555	photosystem II stabilization
LA08_RS06715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA08_RS06730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA08_RS06755	COG0228	four-way junction DNA binding
LA08_RS06760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LA08_RS06765	COG0336	Belongs to the RNA methyltransferase TrmD family
LA08_RS06780	COG0534	Mate efflux family protein
LA08_RS06820	COG0542	response to heat
LA08_RS06860	COG4206	TonB-dependent receptor
LA08_RS06920	COG0019	diaminopimelate decarboxylase activity
LA08_RS06930	COG2814	Major facilitator Superfamily
LA08_RS06935	COG4264	IucA IucC family
LA08_RS06945	COG4772	TonB-dependent receptor
LA08_RS06960	COG4651	solute:proton antiporter activity
LA08_RS06960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA08_RS06995	COG0488	(ABC) transporter
LA08_RS07020	COG0657	acetylesterase activity
LA08_RS07020	COG2755	lipolytic protein G-D-S-L family
LA08_RS07040	COG2207	Transcriptional regulator
LA08_RS07045	COG0326	Molecular chaperone. Has ATPase activity
LA08_RS07075	COG3328	transposase activity
LA08_RS07080	COG0174	glutamine synthetase
LA08_RS07085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LA08_RS07095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LA08_RS07110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LA08_RS07140	COG2146	nitrite reductase [NAD(P)H] activity
LA08_RS07150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LA08_RS07155	COG0719	Fe-S assembly protein
LA08_RS07160	COG0396	ATPase activity
LA08_RS07165	COG0719	Fe-S assembly protein
LA08_RS07170	COG1959	2 iron, 2 sulfur cluster binding
LA08_RS07190	COG0693	protein deglycase activity
LA08_RS07235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LA08_RS07270	COG0519	Catalyzes the synthesis of GMP from XMP
LA08_RS07280	COG1678	Uncharacterized ACR, COG1678
LA08_RS07285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LA08_RS07300	COG1764	response to oxidative stress
LA08_RS07310	COG0384	phenazine biosynthesis protein PhzF
LA08_RS07320	COG0527	aspartate kinase activity
LA08_RS07350	COG0142	geranyltranstransferase activity
LA08_RS07355	COG0629	single-stranded DNA binding
LA08_RS07360	COG2203	Gaf domain
LA08_RS07360	COG3706	GGDEF domain
LA08_RS07360	COG4251	negative regulation of phosphorylation
LA08_RS07360	COG5001	Diguanylate cyclase
LA08_RS07395	COG2879	small protein
LA08_RS07400	COG1966	Carbon starvation protein
LA08_RS07405	COG1741	Belongs to the pirin family
LA08_RS07520	COG1741	Belongs to the pirin family
LA08_RS07530	COG1515	deoxyribonuclease V activity
LA08_RS07550	COG3590	peptidase
LA08_RS07565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LA08_RS07570	COG2199	diguanylate cyclase activity
LA08_RS07570	COG2202	Pas domain
LA08_RS07570	COG2200	EAL domain
LA08_RS07575	COG0835	chemotaxis
LA08_RS07580	COG0840	transmembrane signaling receptor activity
LA08_RS07585	COG0643	Histidine kinase
LA08_RS07585	COG2198	Histidine kinase
LA08_RS07595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA08_RS07605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LA08_RS07625	COG2205	protein histidine kinase activity
LA08_RS07640	COG3039	Transposase
LA08_RS07660	COG3039	Transposase
LA08_RS07685	COG3039	Transposase
LA08_RS07705	COG3039	Transposase
LA08_RS07735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA08_RS07740	COG0735	belongs to the Fur family
LA08_RS07800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LA08_RS07805	COG0084	hydrolase, TatD family'
LA08_RS07820	COG1960	acyl-CoA dehydrogenase activity
LA08_RS07835	COG0367	asparagine synthase
LA08_RS07845	COG0305	Participates in initiation and elongation during chromosome replication
LA08_RS07850	COG0415	Belongs to the DNA photolyase family
LA08_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS07915	COG3039	Transposase
LA08_RS07975	COG5001	Diguanylate cyclase
LA08_RS07975	COG5002	protein histidine kinase activity
LA08_RS07980	COG1187	pseudouridine synthase activity
LA08_RS08005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA08_RS08015	COG0475	glutathione-regulated potassium exporter activity
LA08_RS08020	COG5002	protein histidine kinase activity
LA08_RS08020	COG5000	phosphorelay sensor kinase activity
LA08_RS08025	COG0745	RESPONSE REGULATOR receiver
LA08_RS08055	COG1132	(ABC) transporter
LA08_RS08080	COG3039	Transposase
LA08_RS08095	COG3039	Transposase
LA08_RS08140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LA08_RS08150	COG4969	Belongs to the N-Me-Phe pilin family
LA08_RS08155	COG2194	sulfuric ester hydrolase activity
LA08_RS08195	COG0045	succinate-CoA ligase (ADP-forming) activity
LA08_RS08200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LA08_RS08215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LA08_RS08215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA08_RS08220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA08_RS08225	COG0564	pseudouridine synthase activity
LA08_RS08250	COG3387	PFAM Glycoside hydrolase 15-related
LA08_RS08255	COG1877	trehalose-phosphatase activity
LA08_RS08295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LA08_RS08315	COG1595	DNA-templated transcription, initiation
LA08_RS08325	COG1946	Acyl-CoA thioesterase
LA08_RS08340	COG0824	Thioesterase
LA08_RS08345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LA08_RS08355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LA08_RS08360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LA08_RS08365	COG0268	Binds directly to 16S ribosomal RNA
LA08_RS08370	COG0728	peptidoglycan biosynthetic process
LA08_RS08375	COG0196	riboflavin kinase activity
LA08_RS08385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LA08_RS08390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LA08_RS08405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LA08_RS08410	COG1845	cytochrome c oxidase, subunit III
LA08_RS08415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LA08_RS08435	COG3209	COG3209 Rhs family protein
LA08_RS08435	COG3209	COG3209 Rhs family protein
LA08_RS08555	COG0632	four-way junction helicase activity
LA08_RS08565	COG2255	four-way junction helicase activity
LA08_RS08570	COG0824	Thioesterase
LA08_RS08580	COG0848	biopolymer transport protein
LA08_RS08595	COG2885	chlorophyll binding
LA08_RS08605	COG0602	queuosine metabolic process
LA08_RS08615	COG1187	pseudouridine synthase activity
LA08_RS08675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LA08_RS08700	COG0514	ATP-dependent DNA helicase (RecQ)
LA08_RS08710	COG0783	Belongs to the Dps family
LA08_RS08715	COG1643	Atp-dependent helicase
LA08_RS08770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA08_RS08780	COG1215	transferase activity, transferring glycosyl groups
LA08_RS08785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA08_RS08795	COG1199	ATP-dependent helicase activity
LA08_RS08805	COG1397	ADP-ribosylglycohydrolase
LA08_RS08815	COG0189	ligase activity
LA08_RS08830	COG0835	chemotaxis
LA08_RS08835	COG0840	transmembrane signaling receptor activity
LA08_RS08840	COG2198	Histidine kinase
LA08_RS08840	COG0643	Histidine kinase
LA08_RS08840	COG0784	Response regulator, receiver
LA08_RS08885	COG1446	asparaginase
LA08_RS08890	COG3142	Participates in the control of copper homeostasis
LA08_RS08945	COG3537	Alpha-1,2-mannosidase
LA08_RS09015	COG1472	Belongs to the glycosyl hydrolase 3 family
LA08_RS09035	COG1388	LysM domain
LA08_RS09035	COG3858	chitin binding
LA08_RS09050	COG0837	glucose binding
LA08_RS09055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA08_RS09065	COG0494	nUDIX hydrolase
LA08_RS09075	COG3956	TIGRFAM MazG family protein
LA08_RS09080	COG1742	UPF0060 membrane protein
LA08_RS09090	COG0330	HflC and HflK could
LA08_RS09105	COG0509	glycine decarboxylation via glycine cleavage system
LA08_RS09140	COG1960	acyl-CoA dehydrogenase activity
LA08_RS09150	COG1309	transcriptional regulator
LA08_RS09155	COG4771	TonB-dependent receptor
LA08_RS09165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LA08_RS09175	COG0463	Glycosyl transferase, family 2
LA08_RS09195	COG1272	protein, Hemolysin III
LA08_RS09205	COG0739	heme binding
LA08_RS09210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA08_RS09215	COG0626	cystathionine gamma-synthase activity
LA08_RS09225	COG1760	l-serine dehydratase
LA08_RS09240	COG2353	YceI-like domain
LA08_RS09250	COG2353	YceI-like domain
LA08_RS09300	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LA08_RS09320	COG1960	acyl-CoA dehydrogenase activity
LA08_RS09325	COG1024	Enoyl-CoA hydratase
LA08_RS09345	COG1024	Enoyl-CoA hydratase
LA08_RS09345	COG1250	3-hydroxyacyl-CoA dehydrogenase
LA08_RS09360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA08_RS09390	COG1381	Involved in DNA repair and RecF pathway recombination
LA08_RS09405	COG2954	triphosphatase activity
LA08_RS09420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LA08_RS09425	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LA08_RS09430	COG3046	protein related to deoxyribodipyrimidine photolyase
LA08_RS09440	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LA08_RS09445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LA08_RS09450	COG1278	Cold shock
LA08_RS09470	COG1201	RNA secondary structure unwinding
LA08_RS09475	COG1793	dna ligase
LA08_RS09485	COG1793	dna ligase
LA08_RS09485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LA08_RS09515	COG0183	Belongs to the thiolase family
LA08_RS09540	COG1451	nucleotide metabolic process
LA08_RS09555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LA08_RS09600	COG1047	Peptidyl-prolyl cis-trans
LA08_RS09615	COG2824	Alkylphosphonate utilization operon protein PhnA
LA08_RS09630	COG1902	pentaerythritol trinitrate reductase activity
LA08_RS09635	COG2814	Major facilitator Superfamily
LA08_RS09690	COG0392	lysyltransferase activity
LA08_RS09690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LA08_RS09700	COG0251	oxidation-reduction process
LA08_RS09705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA08_RS09720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA08_RS09745	COG1595	DNA-templated transcription, initiation
LA08_RS09765	COG2878	Part of a membrane complex involved in electron transport
LA08_RS09775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA08_RS09775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA08_RS09795	COG0833	amino acid
LA08_RS09800	COG2040	homocysteine
LA08_RS09815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LA08_RS09850	COG2895	sulfate adenylyltransferase (ATP) activity
LA08_RS09850	COG0529	Catalyzes the synthesis of activated sulfate
LA08_RS09895	COG1981	membrane
LA08_RS09920	COG1131	(ABC) transporter
LA08_RS09925	COG4771	TonB-dependent receptor
LA08_RS09935	COG0825	malonyl-CoA metabolic process
LA08_RS09955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA08_RS09960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA08_RS09980	COG0750	zinc metalloprotease
LA08_RS09990	COG0575	Belongs to the CDS family
LA08_RS10000	COG0233	cytoplasmic translational termination
LA08_RS10015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LA08_RS10075	COG1393	Belongs to the ArsC family
LA08_RS10090	COG0367	asparagine synthase
LA08_RS10105	COG4774	siderophore transport
LA08_RS10145	COG1566	PFAM secretion protein HlyD family protein
LA08_RS10150	COG2814	Major facilitator Superfamily
LA08_RS10195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LA08_RS10205	COG1960	acyl-CoA dehydrogenase activity
LA08_RS10230	COG2914	Belongs to the UPF0125 (RnfH) family
LA08_RS10240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA08_RS10250	COG0497	DNA recombination
LA08_RS10260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LA08_RS10265	COG0443	Heat shock 70 kDa protein
LA08_RS10270	COG0484	heat shock protein binding
LA08_RS10280	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LA08_RS10285	COG0287	Prephenate dehydrogenase
LA08_RS10285	COG1605	Chorismate mutase
LA08_RS10305	COG0583	DNA-binding transcription factor activity
LA08_RS10320	COG1132	(ABC) transporter
LA08_RS10355	COG2850	peptidyl-arginine hydroxylation
LA08_RS10435	COG1131	(ABC) transporter
LA08_RS10440	COG1725	Transcriptional regulator
LA08_RS10450	COG0386	Belongs to the glutathione peroxidase family
LA08_RS10465	COG2900	Belongs to the SlyX family
LA08_RS10480	COG1609	Transcriptional regulator
LA08_RS10490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA08_RS10500	COG1410	methionine synthase
LA08_RS10500	COG0646	methionine synthase
LA08_RS10505	COG0646	methionine synthase
LA08_RS10505	COG1410	methionine synthase
LA08_RS10510	COG2226	methyltransferase
LA08_RS10515	COG1960	acyl-CoA dehydrogenase activity
LA08_RS10545	COG0557	exoribonuclease II activity
LA08_RS10565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA08_RS10580	COG3039	Transposase
LA08_RS10605	COG3328	transposase activity
LA08_RS10615	COG1278	Cold shock
LA08_RS10630	COG3039	Transposase
LA08_RS10635	COG3039	Transposase
LA08_RS10685	COG3039	Transposase
LA08_RS10695	COG0583	DNA-binding transcription factor activity
LA08_RS10755	COG2201	protein-glutamate methylesterase activity
LA08_RS10790	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LA08_RS10800	COG0531	amino acid
LA08_RS10805	COG0531	amino acid
LA08_RS10815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA08_RS10820	COG0277	FAD linked oxidase domain protein
LA08_RS10885	COG0436	Aminotransferase
LA08_RS10910	COG1187	pseudouridine synthase activity
LA08_RS10915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LA08_RS10920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LA08_RS10925	COG2350	Protein conserved in bacteria
LA08_RS10955	COG1175	transmembrane transport
LA08_RS10960	COG0395	ABC-type sugar transport system, permease component
LA08_RS10985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA08_RS10995	COG2957	Belongs to the agmatine deiminase family
LA08_RS11010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LA08_RS11015	COG0539	negative regulation of cytoplasmic translation
LA08_RS11020	COG0776	regulation of translation
LA08_RS11030	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LA08_RS11035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA08_RS11045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA08_RS11065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LA08_RS11080	COG3002	Belongs to the UPF0753 family
LA08_RS11085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LA08_RS11090	COG0583	DNA-binding transcription factor activity
LA08_RS11120	COG0583	DNA-binding transcription factor activity
LA08_RS11145	COG1914	H( )-stimulated, divalent metal cation uptake system
LA08_RS11165	COG0668	transmembrane transport
LA08_RS11205	COG3039	Transposase
LA08_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS11230	COG1183	phosphatidylcholine synthase activity
LA08_RS11240	COG3243	poly(R)-hydroxyalkanoic acid synthase
LA08_RS11255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA08_RS11255	COG0723	plastoquinol--plastocyanin reductase activity
LA08_RS11265	COG2183	response to ionizing radiation
LA08_RS11280	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LA08_RS11295	COG0671	phosphoesterase, PA-phosphatase related
LA08_RS11320	COG1794	racemase activity, acting on amino acids and derivatives
LA08_RS11330	COG0697	spore germination
LA08_RS11355	COG1012	belongs to the aldehyde dehydrogenase family
LA08_RS11390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LA08_RS11405	COG0124	histidyl-tRNA synthetase
LA08_RS11425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LA08_RS11440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA08_RS11440	COG0131	Imidazoleglycerol-phosphate dehydratase
LA08_RS11450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LA08_RS11460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LA08_RS11460	COG0140	phosphoribosyl-ATP diphosphatase activity
LA08_RS11500	COG0653	protein targeting
LA08_RS11655	COG2201	protein-glutamate methylesterase activity
LA08_RS11665	COG2801	Transposase and inactivated derivatives
LA08_RS11680	COG3039	Transposase
LA08_RS11705	COG3328	transposase activity
LA08_RS11740	COG0322	excinuclease ABC activity
LA08_RS11750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LA08_RS11760	COG1663	tetraacyldisaccharide 4'-kinase activity
LA08_RS11775	COG0811	peptide transport
LA08_RS11805	COG4591	ABC-type transport system involved in lipoprotein release permease component
LA08_RS11820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LA08_RS11835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LA08_RS11850	COG0354	folic acid binding
LA08_RS11865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA08_RS11875	COG0363	glucosamine-6-phosphate deaminase activity
LA08_RS11880	COG0129	dihydroxy-acid dehydratase activity
LA08_RS11885	COG0800	Aldolase
LA08_RS11915	COG0784	Response regulator, receiver
LA08_RS11915	COG2205	protein histidine kinase activity
LA08_RS11915	COG5002	protein histidine kinase activity
LA08_RS12000	COG0386	Belongs to the glutathione peroxidase family
LA08_RS12090	COG4251	negative regulation of phosphorylation
LA08_RS12090	COG3706	GGDEF domain
LA08_RS12090	COG2203	Gaf domain
LA08_RS12090	COG5001	Diguanylate cyclase
LA08_RS12110	COG1472	Belongs to the glycosyl hydrolase 3 family
LA08_RS12160	COG0617	tRNA 3'-terminal CCA addition
LA08_RS12170	COG1469	GTP cyclohydrolase I activity
LA08_RS12175	COG0860	N-Acetylmuramoyl-L-alanine amidase
LA08_RS12225	COG4566	intracellular signal transduction
LA08_RS12265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LA08_RS12270	COG0077	Prephenate dehydratase
LA08_RS12270	COG1605	Chorismate mutase
LA08_RS12280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LA08_RS12325	COG1228	amidohydrolase
LA08_RS12330	COG2986	histidine ammonia-lyase
LA08_RS12340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LA08_RS12365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LA08_RS12380	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LA08_RS12395	COG3115	cell septum assembly
LA08_RS12405	COG0359	binds to the 23S rRNA
LA08_RS12415	COG0360	Binds together with S18 to 16S ribosomal RNA
LA08_RS12420	COG0316	Belongs to the HesB IscA family
LA08_RS12455	COG0288	reversible hydration of carbon dioxide
LA08_RS12480	COG2925	Exonuclease
LA08_RS12490	COG0667	Aldo Keto reductase
LA08_RS12515	COG0116	Belongs to the methyltransferase superfamily
LA08_RS12515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LA08_RS12560	COG0494	nUDIX hydrolase
LA08_RS12570	COG1024	Enoyl-CoA hydratase
LA08_RS12580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA08_RS12595	COG3039	Transposase
LA08_RS12635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LA08_RS12640	COG0573	inorganic phosphate transmembrane transporter activity
LA08_RS12655	COG0704	Plays a role in the regulation of phosphate uptake
LA08_RS12665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA08_RS12680	COG3328	transposase activity
LA08_RS12715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA08_RS12720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA08_RS12725	COG1862	Preprotein translocase
LA08_RS12730	COG0343	queuine tRNA-ribosyltransferase activity
LA08_RS12815	COG0405	Gamma-glutamyltransferase
LA08_RS12820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA08_RS12835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LA08_RS12840	COG0742	ribosomal rna small subunit methyltransferase
LA08_RS12860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA08_RS12890	COG3039	Transposase
LA08_RS12900	COG3039	Transposase
LA08_RS12930	COG0303	'Molybdopterin
LA08_RS12940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA08_RS12950	COG1426	Protein conserved in bacteria
LA08_RS12960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LA08_RS12975	COG1250	3-hydroxyacyl-CoA dehydrogenase
LA08_RS12975	COG1024	Enoyl-CoA hydratase
LA08_RS12980	COG0183	Belongs to the thiolase family
LA08_RS12985	COG0038	chloride channel
LA08_RS13005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA08_RS13030	COG1674	ftsk spoiiie
LA08_RS13035	COG0492	ferredoxin-NADP+ reductase activity
LA08_RS13060	COG0542	response to heat
LA08_RS13075	COG0482	sulfurtransferase activity
LA08_RS13100	COG5001	Diguanylate cyclase
LA08_RS13105	COG4585	Histidine kinase
LA08_RS13115	COG5002	protein histidine kinase activity
LA08_RS13135	COG0835	chemotaxis
LA08_RS13135	COG0784	Response regulator, receiver
LA08_RS13145	COG1558	bacterial-type flagellum-dependent cell motility
LA08_RS13150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LA08_RS13160	COG4787	bacterial-type flagellum-dependent cell motility
LA08_RS13200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA08_RS13205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LA08_RS13235	COG2201	protein-glutamate methylesterase activity
LA08_RS13255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LA08_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS13300	COG1677	Flagellar hook-basal body complex protein FliE
LA08_RS13350	COG3190	flagellar
LA08_RS13370	COG1684	flagellar biosynthetic protein fliR
LA08_RS13425	COG2198	Histidine kinase
LA08_RS13425	COG0643	Histidine kinase
LA08_RS13425	COG0784	Response regulator, receiver
LA08_RS13465	COG3039	Transposase
LA08_RS13555	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LA08_RS13560	COG4988	ABC transporter
LA08_RS13585	COG1271	oxidase subunit
LA08_RS13620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LA08_RS13640	COG0165	Argininosuccinate lyase
LA08_RS13655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LA08_RS13660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LA08_RS13670	COG0137	argininosuccinate synthase activity
LA08_RS13675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LA08_RS13690	COG2166	iron-sulfur cluster assembly
LA08_RS13715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LA08_RS13755	COG3039	Transposase
LA08_RS13770	COG4677	pectinesterase activity
LA08_RS13800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA08_RS13805	COG0402	S-adenosylhomocysteine deaminase activity
LA08_RS13820	COG1509	lysine 2,3-aminomutase activity
LA08_RS13825	COG5001	Diguanylate cyclase
LA08_RS13825	COG3300	MHYT domain
LA08_RS13840	COG0483	inositol monophosphate 1-phosphatase activity
LA08_RS13845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA08_RS13870	COG0488	(ABC) transporter
LA08_RS13875	COG0513	Belongs to the DEAD box helicase family
LA08_RS13895	COG0625	glutathione transferase activity
LA08_RS13905	COG1671	Belongs to the UPF0178 family
LA08_RS13910	COG4681	YaeQ
LA08_RS13915	COG2081	HI0933 family
LA08_RS13935	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS13960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LA08_RS13965	COG0860	N-Acetylmuramoyl-L-alanine amidase
LA08_RS13970	COG0802	atpase or kinase
LA08_RS13975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LA08_RS13975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LA08_RS13980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LA08_RS14005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LA08_RS14090	COG3328	transposase activity
LA08_RS14135	COG2969	positive regulation of protein catabolic process
LA08_RS14140	COG0625	glutathione transferase activity
LA08_RS14145	COG2857	Cytochrome c1
LA08_RS14150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LA08_RS14155	COG0723	plastoquinol--plastocyanin reductase activity
LA08_RS14165	COG0741	lytic transglycosylase activity
LA08_RS14190	COG1702	phosphate starvation-inducible protein PhoH
LA08_RS14210	COG4535	Mg2 and Co2 transporter CorC
LA08_RS14225	COG1012	belongs to the aldehyde dehydrogenase family
LA08_RS14235	COG1177	transmembrane transport
LA08_RS14245	COG3842	ATPase activity
LA08_RS14285	COG0174	glutamine synthetase
LA08_RS14290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA08_RS14300	COG0477	Major facilitator Superfamily
LA08_RS14310	COG0243	molybdopterin cofactor binding
LA08_RS14320	COG2223	nitrite transmembrane transporter activity
LA08_RS14340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA08_RS14345	COG1121	(ABC) transporter
LA08_RS14355	COG2733	membrane
LA08_RS14360	COG5002	protein histidine kinase activity
LA08_RS14360	COG2205	protein histidine kinase activity
LA08_RS14360	COG0784	Response regulator, receiver
LA08_RS14370	COG3039	Transposase
LA08_RS14380	COG2902	Dehydrogenase
LA08_RS14390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA08_RS14395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA08_RS14415	COG1609	Transcriptional regulator
LA08_RS14420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA08_RS14420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA08_RS14425	COG1105	Belongs to the carbohydrate kinase PfkB family
LA08_RS14430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA08_RS14430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA08_RS14445	COG3039	Transposase
LA08_RS14455	COG3039	Transposase
LA08_RS14580	COG3039	Transposase
LA08_RS14610	COG4771	TonB-dependent receptor
LA08_RS14620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA08_RS14640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA08_RS14645	COG1360	Flagellar Motor Protein
LA08_RS14655	COG0835	chemotaxis
LA08_RS14665	COG0745	RESPONSE REGULATOR receiver
LA08_RS14690	COG0840	transmembrane signaling receptor activity
LA08_RS14705	COG0840	transmembrane signaling receptor activity
LA08_RS14715	COG0840	transmembrane signaling receptor activity
LA08_RS14725	COG0840	transmembrane signaling receptor activity
LA08_RS14730	COG0840	transmembrane signaling receptor activity
LA08_RS14735	COG0840	transmembrane signaling receptor activity
LA08_RS14740	COG0840	transmembrane signaling receptor activity
LA08_RS14760	COG0835	chemotaxis
LA08_RS14785	COG0840	transmembrane signaling receptor activity
LA08_RS14820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA08_RS14850	COG0318	PFAM AMP-dependent synthetase and ligase
LA08_RS14855	COG1024	Enoyl-CoA hydratase
LA08_RS14860	COG0784	Response regulator, receiver
LA08_RS14860	COG2198	Histidine kinase
LA08_RS14860	COG2205	protein histidine kinase activity
LA08_RS14930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LA08_RS14940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA08_RS14945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LA08_RS14955	COG0505	Belongs to the CarA family
LA08_RS14960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LA08_RS14970	COG2258	MOSC domain
LA08_RS14975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA08_RS15025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LA08_RS15045	COG0477	Major facilitator Superfamily
LA08_RS15055	COG1070	Carbohydrate kinase
LA08_RS15065	COG1501	Belongs to the glycosyl hydrolase 31 family
LA08_RS15080	COG0800	Aldolase
LA08_RS15085	COG4948	Mandelate Racemase Muconate Lactonizing
LA08_RS15095	COG3734	2-keto-3-deoxy-galactonokinase
LA08_RS15100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LA08_RS15110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA08_RS15125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LA08_RS15130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LA08_RS15140	COG0351	phosphomethylpyrimidine kinase
LA08_RS15170	COG0583	DNA-binding transcription factor activity
LA08_RS15175	COG1741	Belongs to the pirin family
LA08_RS15195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LA08_RS15200	COG0305	Participates in initiation and elongation during chromosome replication
LA08_RS15225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LA08_RS15230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LA08_RS15235	COG2137	regulation of response to DNA damage stimulus
LA08_RS15245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LA08_RS15260	COG1546	Belongs to the CinA family
LA08_RS15265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA08_RS15280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LA08_RS15290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LA08_RS15295	COG1534	Rna-binding protein
LA08_RS15310	COG1238	metal cluster binding
LA08_RS15315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LA08_RS15320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LA08_RS15325	COG2840	Smr protein MutS2
LA08_RS15340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LA08_RS15355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LA08_RS15360	COG0148	phosphopyruvate hydratase activity
LA08_RS15370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LA08_RS15375	COG0504	CTP synthase activity
LA08_RS15400	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LA08_RS15405	COG0306	phosphate transporter
LA08_RS15420	COG1253	flavin adenine dinucleotide binding
LA08_RS15435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LA08_RS15455	COG0477	Major facilitator Superfamily
LA08_RS15465	COG1132	(ABC) transporter
LA08_RS15470	COG1136	(ABC) transporter
LA08_RS15490	COG0438	transferase activity, transferring glycosyl groups
LA08_RS15500	COG2264	protein methyltransferase activity
LA08_RS15530	COG2244	polysaccharide biosynthetic process
LA08_RS15580	COG1595	DNA-templated transcription, initiation
LA08_RS15595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA08_RS15615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA08_RS15630	COG2201	protein-glutamate methylesterase activity
LA08_RS15650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA08_RS15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA08_RS15710	COG1858	cytochrome C peroxidase
LA08_RS15745	COG0515	serine threonine protein kinase
LA08_RS15750	COG0631	protein serine/threonine phosphatase activity
LA08_RS15860	COG3039	Transposase
LA08_RS15880	COG3039	Transposase
LA08_RS15925	COG0316	Belongs to the HesB IscA family
LA08_RS15925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LA08_RS15930	COG2154	pterin-4-alpha-carbinolamine dehydratase
LA08_RS15940	COG0428	transporter
LA08_RS15945	COG0428	transporter
LA08_RS15950	COG3064	Membrane
LA08_RS15960	COG1530	ribonuclease E activity
LA08_RS15980	COG1054	Belongs to the UPF0176 family
LA08_RS15985	COG3039	Transposase
LA08_RS16005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LA08_RS16045	COG3039	Transposase
LA08_RS16050	COG3039	Transposase
LA08_RS16080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LA08_RS16080	COG1648	precorrin-2 dehydrogenase activity
LA08_RS16105	COG0746	molybdenum cofactor guanylyltransferase activity
LA08_RS16180	COG3328	transposase activity
LA08_RS16185	COG4206	TonB-dependent receptor
LA08_RS16220	COG4206	TonB-dependent receptor
LA08_RS16270	COG0531	amino acid
LA08_RS16285	COG0006	proline dipeptidase activity
LA08_RS16295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA08_RS16310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA08_RS16315	COG3938	Belongs to the proline racemase family
LA08_RS16325	COG0552	protein localization to endoplasmic reticulum
LA08_RS16350	COG4191	Histidine kinase
LA08_RS16350	COG0784	Response regulator, receiver
LA08_RS16440	COG3040	lipid binding
LA08_RS16480	COG0438	transferase activity, transferring glycosyl groups
LA08_RS16490	COG0438	transferase activity, transferring glycosyl groups
LA08_RS16495	COG0438	transferase activity, transferring glycosyl groups
LA08_RS16565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LA08_RS16600	COG0556	nucleotide-excision repair
LA08_RS16605	COG4969	Belongs to the N-Me-Phe pilin family
LA08_RS16645	COG1611	Belongs to the LOG family
LA08_RS16660	COG2095	MarC family integral membrane protein
LA08_RS16670	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA08_RS16705	COG1185	polyribonucleotide nucleotidyltransferase activity
LA08_RS16710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LA08_RS16730	COG0195	Participates in both transcription termination and antitermination
LA08_RS16735	COG0779	Required for maturation of 30S ribosomal subunits
LA08_RS16745	COG1007	ATP synthesis coupled electron transport
LA08_RS16780	COG1034	ATP synthesis coupled electron transport
LA08_RS16785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LA08_RS16790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LA08_RS16795	COG0649	NAD binding
LA08_RS16800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA08_RS16810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA08_RS16825	COG0149	triose-phosphate isomerase activity
LA08_RS16875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA08_RS16880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LA08_RS16905	COG0135	phosphoribosylanthranilate isomerase activity
LA08_RS16910	COG0101	tRNA pseudouridine synthase activity
LA08_RS16930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA08_RS16935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA08_RS16940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LA08_RS16945	COG2890	protein-(glutamine-N5) methyltransferase activity
LA08_RS17000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA08_RS17010	COG0412	Dienelactone hydrolase
LA08_RS17035	COG0717	Belongs to the dCTP deaminase family
LA08_RS17040	COG0489	protein tyrosine kinase activity
LA08_RS17085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA08_RS17090	COG2311	Membrane
LA08_RS17095	COG1047	Peptidyl-prolyl cis-trans
LA08_RS17100	COG0791	NLP P60 protein
LA08_RS17105	COG0791	NLP P60 protein
LA08_RS17120	COG1301	dicarboxylic acid transport
LA08_RS17125	COG1785	Belongs to the alkaline phosphatase family
LA08_RS17130	COG0037	tRNA processing
LA08_RS17135	COG1722	exodeoxyribonuclease VII activity
LA08_RS17140	COG0142	geranyltranstransferase activity
LA08_RS17165	COG0312	modulator of DNA gyrase
LA08_RS17170	COG3028	Belongs to the UPF0307 family
LA08_RS17175	COG0312	modulator of DNA gyrase
LA08_RS17185	COG3164	Protein of unknown function
LA08_RS17200	COG2968	Membrane
LA08_RS17225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LA08_RS17250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LA08_RS17280	COG3118	belongs to the thioredoxin family
LA08_RS17360	COG3039	Transposase
LA08_RS17365	COG3039	Transposase
LA08_RS17460	COG2022	thiamine diphosphate biosynthetic process
LA08_RS17475	COG0471	metal ion transport
LA08_RS17475	COG3273	potassium ion transport
LA08_RS17505	COG1970	mechanosensitive ion channel activity
LA08_RS17530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA08_RS17560	COG0308	aminopeptidase N
LA08_RS17565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA08_RS17580	COG2895	sulfate adenylyltransferase (ATP) activity
LA08_RS17580	COG0529	Catalyzes the synthesis of activated sulfate
LA08_RS17585	COG0175	sulfate reduction
LA08_RS17590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA08_RS17595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA08_RS17600	COG0175	sulfate reduction
LA08_RS17620	COG2205	protein histidine kinase activity
LA08_RS17620	COG0784	Response regulator, receiver
LA08_RS17620	COG2198	Histidine kinase
LA08_RS17665	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LA08_RS17670	COG3588	fructose-bisphosphate aldolase
LA08_RS17675	COG0469	pyruvate kinase activity
LA08_RS17720	COG0753	catalase activity
LA08_RS17745	COG3039	Transposase
LA08_RS17765	COG1917	Cupin 2, conserved barrel domain protein
LA08_RS17765	COG2207	Transcriptional regulator
LA08_RS17795	COG0823	Involved in the tonB-independent uptake of proteins
LA08_RS17795	COG1506	peptidase
LA08_RS17820	COG3039	Transposase
LA08_RS17825	COG1297	OPT oligopeptide transporter protein
LA08_RS17930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LA08_RS17935	COG3039	Transposase
LA08_RS17950	COG0732	type I restriction modification DNA specificity domain
LA08_RS17955	COG3039	Transposase
LA08_RS17965	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
LA08_RS17970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LA08_RS17990	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LA08_RS18195	COG3039	Transposase
LA08_RS18330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LA08_RS18345	COG2197	response regulator
LA08_RS18350	COG4585	Histidine kinase
LA08_RS18370	COG2894	cell division
LA08_RS18375	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LA08_RS18385	COG0642	Histidine kinase
LA08_RS18390	COG0745	RESPONSE REGULATOR receiver
LA08_RS18395	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LA08_RS18405	COG2194	sulfuric ester hydrolase activity
LA08_RS18435	COG3551	Protein conserved in bacteria
LA08_RS18500	COG0203	ribosomal protein L17
LA08_RS18510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LA08_RS18515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LA08_RS18525	COG0201	protein transport
LA08_RS18535	COG1841	ribosomal large subunit assembly
LA08_RS18565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LA08_RS18575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LA08_RS18580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LA08_RS18585	COG0255	Belongs to the universal ribosomal protein uL29 family
LA08_RS18590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LA08_RS18600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LA08_RS18615	COG0089	rRNA binding
LA08_RS18620	COG0088	Forms part of the polypeptide exit tunnel
LA08_RS18625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LA08_RS18630	COG0051	transcription antitermination factor activity, RNA binding
LA08_RS18650	COG0049	tRNA binding
LA08_RS18655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LA08_RS18660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LA08_RS18665	COG0085	RNA polymerase activity
LA08_RS18670	COG0222	ribosome binding
LA08_RS18675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LA08_RS18685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LA08_RS18695	COG0250	Participates in transcription elongation, termination and antitermination
LA08_RS18700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA08_RS18730	COG0012	GTP binding
LA08_RS18735	COG0193	aminoacyl-tRNA hydrolase activity
LA08_RS18745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LA08_RS18760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LA08_RS18775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LA08_RS18785	COG0521	Mo-molybdopterin cofactor biosynthetic process
LA08_RS18805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA08_RS18810	COG1295	ribonuclease BN
LA08_RS18840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LA08_RS18850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LA08_RS18880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LA08_RS18905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LA08_RS18920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA08_RS18920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA08_RS18970	COG2890	protein-(glutamine-N5) methyltransferase activity
LA08_RS18980	COG3634	alkyl hydroperoxide reductase activity
LA08_RS18985	COG0583	DNA-binding transcription factor activity
LA08_RS18995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA08_RS19075	COG4783	chaperone-mediated protein folding
LA08_RS19090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LA08_RS19100	COG0438	transferase activity, transferring glycosyl groups
LA08_RS19105	COG0671	phosphoesterase, PA-phosphatase related
LA08_RS19110	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA08_RS19130	COG2833	Protein of unknown function (DUF455)
LA08_RS19150	COG0285	dihydrofolate synthase activity
LA08_RS19160	COG0406	alpha-ribazole phosphatase activity
LA08_RS19195	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LA08_RS19200	COG4208	sulfate ABC transporter
LA08_RS19205	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LA08_RS19210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA08_RS19215	COG0156	8-amino-7-oxononanoate synthase activity
LA08_RS19245	COG0604	alcohol dehydrogenase
LA08_RS19250	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA08_RS19250	COG1902	pentaerythritol trinitrate reductase activity
LA08_RS19385	COG3386	PFAM SMP-30 Gluconolaconase
LA08_RS19405	COG1024	Enoyl-CoA hydratase
LA08_RS19415	COG0318	PFAM AMP-dependent synthetase and ligase
LA08_RS19420	COG0583	DNA-binding transcription factor activity
LA08_RS19460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA08_RS19465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA08_RS19475	COG2096	Adenosyltransferase
LA08_RS19480	COG0123	including yeast histone deacetylase and acetoin utilization protein
LA08_RS19495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LA08_RS19505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LA08_RS19510	COG2967	ApaG domain
LA08_RS19535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LA08_RS19555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LA08_RS19580	COG0642	Histidine kinase
LA08_RS19595	COG4181	ATPase activity
LA08_RS19605	COG2175	clavaminate synthase activity
LA08_RS19615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LA08_RS19655	COG0667	Aldo Keto reductase
LA08_RS19665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA08_RS19670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA08_RS19690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA08_RS19705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LA08_RS19760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LA08_RS19765	COG2226	methyltransferase
LA08_RS19820	COG0604	alcohol dehydrogenase
LA08_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS19820	COG3321	synthase
LA08_RS19835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LA08_RS19850	COG0494	nUDIX hydrolase
LA08_RS19865	COG1388	LysM domain
LA08_RS19865	COG4942	peptidase
LA08_RS19875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LA08_RS19890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LA08_RS19895	COG1181	Belongs to the D-alanine--D-alanine ligase family
LA08_RS19900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA08_RS19915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA08_RS19920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA08_RS19935	COG3116	cell division
LA08_RS19940	COG0275	rRNA processing
LA08_RS19975	COG0792	nuclease activity
LA08_RS19980	COG1988	membrane-bound metal-dependent
LA08_RS19985	COG0277	FAD linked oxidase domain protein
LA08_RS19990	COG0745	RESPONSE REGULATOR receiver
LA08_RS19995	COG2205	protein histidine kinase activity
LA08_RS20005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LA08_RS20010	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LA08_RS20035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA08_RS20040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA08_RS20045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LA08_RS20065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA08_RS20065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA08_RS20085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LA08_RS20105	COG0488	(ABC) transporter
LA08_RS20155	COG2205	protein histidine kinase activity
LA08_RS20195	COG2205	protein histidine kinase activity
LA08_RS20215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LA08_RS20250	COG3039	Transposase
LA08_RS20255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LA08_RS20270	COG3039	Transposase
LA08_RS20325	COG3039	Transposase
LA08_RS20375	COG1649	PFAM Uncharacterised BCR, COG1649
LA08_RS20375	COG0726	polysaccharide deacetylase
LA08_RS20380	COG1215	transferase activity, transferring glycosyl groups
LA08_RS20390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LA08_RS20395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LA08_RS20400	COG1609	Transcriptional regulator
LA08_RS20410	COG2188	Transcriptional regulator
LA08_RS20425	COG3250	beta-galactosidase activity
LA08_RS20480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA08_RS20485	COG4191	Histidine kinase
LA08_RS20490	COG0784	Response regulator, receiver
LA08_RS20495	COG4251	negative regulation of phosphorylation
LA08_RS20500	COG2823	Periplasmic or secreted lipoprotein
LA08_RS20505	COG0673	inositol 2-dehydrogenase activity
LA08_RS20510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LA08_RS20545	COG1056	cytidyltransferase-related domain
LA08_RS20545	COG1051	belongs to the nudix hydrolase family
LA08_RS20580	COG2921	Belongs to the UPF0250 family
LA08_RS20595	COG1686	Belongs to the peptidase S11 family
LA08_RS20605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LA08_RS20610	COG2951	lytic endotransglycosylase activity
LA08_RS20625	COG5632	N-Acetylmuramoyl-L-alanine amidase
LA08_RS20625	COG3409	Peptidoglycan-binding domain 1 protein
LA08_RS20625	COG1388	LysM domain
LA08_RS20670	COG0772	Belongs to the SEDS family
LA08_RS20685	COG1792	Involved in formation and maintenance of cell shape
LA08_RS20690	COG1077	Cell shape determining protein MreB Mrl
LA08_RS20695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA08_RS20740	COG2199	diguanylate cyclase activity
LA08_RS20745	COG0308	aminopeptidase N
LA08_RS20775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LA08_RS20805	COG0436	Aminotransferase
LA08_RS20820	COG1505	serine-type exopeptidase activity
LA08_RS20845	COG0181	hydroxymethylbilane synthase activity
LA08_RS20855	COG3275	phosphorelay sensor kinase activity
LA08_RS20900	COG0659	secondary active sulfate transmembrane transporter activity
LA08_RS20905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LA08_RS20905	COG5297	Belongs to the glycosyl hydrolase family 6
LA08_RS20980	COG0598	Magnesium transport protein CorA
LA08_RS20990	COG1113	amino acid transport
LA08_RS21000	COG5297	Belongs to the glycosyl hydrolase family 6
LA08_RS21005	COG4305	rare lipoprotein A
LA08_RS21010	COG0697	spore germination
LA08_RS21070	COG4221	oxidoreductase activity
LA08_RS21100	COG0456	acetyltransferase
LA08_RS21110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LA08_RS21165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LA08_RS21165	COG2111	Na H antiporter
LA08_RS21170	COG1006	Multisubunit Na H antiporter MnhC subunit
LA08_RS21175	COG0651	ATP synthesis coupled electron transport
LA08_RS21185	COG2212	antiporter activity
LA08_RS21190	COG1320	monovalent cation:proton antiporter activity
LA08_RS21200	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LA08_RS21220	COG3104	oligopeptide transport
LA08_RS21225	COG3483	tryptophan 2,3-dioxygenase activity
LA08_RS21235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LA08_RS21270	COG0183	Belongs to the thiolase family
LA08_RS21325	COG3039	Transposase
LA08_RS21355	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LA08_RS21360	COG3023	N-Acetylmuramoyl-L-alanine amidase
LA08_RS21370	COG4948	Mandelate Racemase Muconate Lactonizing
LA08_RS21410	COG0531	amino acid
LA08_RS21445	COG4682	membrane
LA08_RS21450	COG2133	pyrroloquinoline quinone binding
LA08_RS21490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LA08_RS21495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LA08_RS21505	COG1610	YqeY-like protein
LA08_RS21520	COG1295	ribonuclease BN
LA08_RS21525	COG0358	DNA primase activity
LA08_RS21590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LA08_RS21605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LA08_RS21655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LA08_RS21660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LA08_RS21665	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LA08_RS21675	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LA08_RS21680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA08_RS21695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LA08_RS21775	COG3039	Transposase
LA08_RS21790	COG3328	transposase activity
LA08_RS21805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LA08_RS21805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LA08_RS21815	COG1473	amidohydrolase
LA08_RS21820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA08_RS21825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA08_RS21840	COG5383	Protein conserved in bacteria
LA08_RS21880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA08_RS21885	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LA08_RS21900	COG0028	Belongs to the TPP enzyme family
LA08_RS21905	COG4191	Histidine kinase
LA08_RS21930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LA08_RS21945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LA08_RS21950	COG3177	Filamentation induced by cAMP protein fic
LA08_RS21965	COG0596	Alpha beta hydrolase
LA08_RS21970	COG0727	PFAM Uncharacterised protein family (UPF0153)
LA08_RS21975	COG0318	PFAM AMP-dependent synthetase and ligase
LA08_RS21980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA08_RS22035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LA08_RS22045	COG0129	dihydroxy-acid dehydratase activity
LA08_RS22070	COG3039	Transposase
LA08_RS22080	COG0408	coproporphyrinogen oxidase activity
LA08_RS22180	COG2353	YceI-like domain
LA08_RS22210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LA08_RS22225	COG3386	PFAM SMP-30 Gluconolaconase
LA08_RS22265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA08_RS22280	COG4771	TonB-dependent receptor
LA08_RS22290	COG0459	protein refolding
LA08_RS22315	COG1252	NADH dehydrogenase
LA08_RS22325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA08_RS22330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LA08_RS22335	COG3437	response regulator, receiver
LA08_RS22340	COG2177	Part of the ABC transporter FtsEX involved in
LA08_RS22345	COG2884	Cell division ATP-binding protein ftsE
LA08_RS22355	COG3118	belongs to the thioredoxin family
LA08_RS22360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LA08_RS22375	COG0729	surface antigen
LA08_RS22380	COG2911	Protein conserved in bacteria
LA08_RS22415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA08_RS22430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA08_RS22490	COG1733	regulation of RNA biosynthetic process
LA08_RS22495	COG0702	epimerase
LA08_RS22530	COG0583	DNA-binding transcription factor activity
LA08_RS22535	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LA08_RS22555	COG0745	RESPONSE REGULATOR receiver
LA08_RS22585	COG1902	pentaerythritol trinitrate reductase activity
LA08_RS22590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LA08_RS22600	COG2814	Major facilitator Superfamily
LA08_RS22605	COG0583	DNA-binding transcription factor activity
LA08_RS22625	COG0084	hydrolase, TatD family'
LA08_RS22675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LA08_RS22695	COG2072	flavoprotein involved in K transport
LA08_RS22745	COG4770	biotin carboxylase activity
LA08_RS22750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LA08_RS22755	COG1960	acyl-CoA dehydrogenase activity
LA08_RS22810	COG0523	cobalamin synthesis protein
LA08_RS22820	COG0697	spore germination
LA08_RS22830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LA08_RS22845	COG4771	TonB-dependent receptor
LA08_RS22850	COG0457	Tetratricopeptide repeat
LA08_RS22865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA08_RS22890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LA08_RS22890	COG0519	Catalyzes the synthesis of GMP from XMP
LA08_RS22900	COG0805	protein transport
LA08_RS22910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LA08_RS22920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LA08_RS22975	COG3661	Belongs to the glycosyl hydrolase 67 family
LA08_RS22985	COG4948	Mandelate Racemase Muconate Lactonizing
LA08_RS22995	COG1472	Belongs to the glycosyl hydrolase 3 family
LA08_RS23000	COG0246	Mannitol dehydrogenase
LA08_RS23025	COG3693	PFAM glycoside hydrolase, family 10
LA08_RS23050	COG2211	Major facilitator Superfamily
LA08_RS23095	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LA08_RS23145	COG1846	Transcriptional regulator
LA08_RS23150	COG1764	response to oxidative stress
LA08_RS23250	COG3549	Plasmid maintenance system killer
LA08_RS23260	COG1074	ATP-dependent DNA helicase activity
LA08_RS23265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LA08_RS23305	COG2032	superoxide dismutase activity
LA08_RS23310	COG2032	superoxide dismutase activity
LA08_RS23315	COG2204	response regulator
LA08_RS23320	COG3852	Histidine kinase
LA08_RS23325	COG0004	ammonium transporteR
LA08_RS23330	COG0347	Belongs to the P(II) protein family
LA08_RS23335	COG0174	glutamine synthetase
LA08_RS23340	COG1968	undecaprenyl-diphosphatase activity
LA08_RS23385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA08_RS23395	COG2062	phosphohistidine phosphatase, SixA
LA08_RS23400	COG0489	protein tyrosine kinase activity
LA08_RS23420	COG1396	sequence-specific DNA binding
LA08_RS23425	COG3550	peptidyl-serine autophosphorylation
LA08_RS23430	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LA08_RS23435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LA08_RS23450	COG0517	IMP dehydrogenase activity
LA08_RS23450	COG1125	glycine betaine transport
LA08_RS23465	COG1119	ATPase activity
LA08_RS23475	COG1752	Esterase of the alpha-beta hydrolase superfamily
LA08_RS23490	COG3039	Transposase
LA08_RS23515	COG0656	L-ascorbic acid biosynthetic process
LA08_RS23520	COG2130	NADP-dependent
LA08_RS23525	COG0667	Aldo Keto reductase
LA08_RS23535	COG1187	pseudouridine synthase activity
LA08_RS23550	COG1643	Atp-dependent helicase
LA08_RS23555	COG4807	Protein conserved in bacteria
LA08_RS23560	COG4948	Mandelate Racemase Muconate Lactonizing
LA08_RS23570	COG0179	Fumarylacetoacetate (FAA) hydrolase
LA08_RS23575	COG1028	Short-chain dehydrogenase reductase Sdr
LA08_RS23595	COG3507	Belongs to the glycosyl hydrolase 43 family
LA08_RS23640	COG3162	membrane
LA08_RS23645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA08_RS23660	COG0708	Exodeoxyribonuclease III
LA08_RS23675	COG2091	lysine biosynthetic process via aminoadipic acid
LA08_RS23685	COG3540	Alkaline phosphatase
LA08_RS23715	COG2159	amidohydrolase
LA08_RS23740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA08_RS23745	COG0583	DNA-binding transcription factor activity
LA08_RS23750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA08_RS23770	COG0210	DNA helicase
LA08_RS23790	COG0531	amino acid
LA08_RS23800	COG1322	Protein conserved in bacteria
LA08_RS23810	COG0386	Belongs to the glutathione peroxidase family
LA08_RS23865	COG0793	Belongs to the peptidase S41A family
LA08_RS23870	COG4942	peptidase
LA08_RS23880	COG2234	aminopeptidase activity
LA08_RS23930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LA08_RS23935	COG0302	gtp cyclohydrolase
LA08_RS23960	COG0477	Major facilitator Superfamily
LA08_RS24065	COG1929	Belongs to the glycerate kinase type-1 family
LA08_RS24070	COG2271	Major facilitator Superfamily
LA08_RS24085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LA08_RS24095	COG0861	Integral membrane protein TerC family
LA08_RS24105	COG0584	glycerophosphoryl diester phosphodiesterase
LA08_RS24115	COG0671	phosphoesterase, PA-phosphatase related
LA08_RS24125	COG0726	polysaccharide deacetylase