locus-tag	class	description
BO992_RS00025	COG0187	DNA topoisomerase II activity
BO992_RS00035	COG0501	Belongs to the peptidase M48B family
BO992_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BO992_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BO992_RS00095	COG4772	TonB-dependent receptor
BO992_RS00110	COG3039	Transposase
BO992_RS00115	COG1304	FMN binding
BO992_RS00120	COG1755	Isoprenylcysteine carboxyl methyltransferase
BO992_RS00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO992_RS00155	COG3039	Transposase
BO992_RS00165	COG1136	(ABC) transporter
BO992_RS00215	COG3039	Transposase
BO992_RS00225	COG0513	Belongs to the DEAD box helicase family
BO992_RS00330	COG1858	cytochrome C peroxidase
BO992_RS00345	COG0702	epimerase
BO992_RS00370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BO992_RS00390	COG1649	PFAM Uncharacterised BCR, COG1649
BO992_RS00395	COG2354	Protein conserved in bacteria
BO992_RS00405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BO992_RS00420	COG3264	Mechanosensitive ion channel
BO992_RS00420	COG1511	domain protein
BO992_RS00500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BO992_RS00580	COG3039	Transposase
BO992_RS00590	COG3039	Transposase
BO992_RS00625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BO992_RS00635	COG0642	Histidine kinase
BO992_RS00645	COG1090	epimerase
BO992_RS00655	COG3039	Transposase
BO992_RS00680	COG2826	transposase and inactivated derivatives, IS30 family
BO992_RS00745	COG1136	(ABC) transporter
BO992_RS00790	COG1272	protein, Hemolysin III
BO992_RS00795	COG1111	helicase
BO992_RS00795	COG1205	dead DEAH box helicase
BO992_RS00860	COG0070	glutamate synthase
BO992_RS00860	COG0067	glutamate synthase
BO992_RS00860	COG0069	glutamate synthase activity
BO992_RS00865	COG0493	'glutamate synthase
BO992_RS00915	COG1609	Transcriptional regulator
BO992_RS00950	COG0366	Alpha amylase catalytic
BO992_RS00955	COG0366	Alpha amylase catalytic
BO992_RS01010	COG0606	chelatase, subunit chli
BO992_RS01055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BO992_RS01060	COG1166	arginine decarboxylase activity
BO992_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BO992_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS01175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BO992_RS01190	COG0210	DNA helicase
BO992_RS01205	COG3132	Protein of unknown function, DUF480
BO992_RS01210	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BO992_RS01215	COG0284	orotidine-5'-phosphate decarboxylase activity
BO992_RS01250	COG2937	Belongs to the GPAT DAPAT family
BO992_RS01280	COG2755	lipolytic protein G-D-S-L family
BO992_RS01295	COG3186	Phenylalanine-4-hydroxylase
BO992_RS01300	COG1522	sequence-specific DNA binding
BO992_RS01350	COG1064	alcohol dehydrogenase
BO992_RS01360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO992_RS01370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO992_RS01380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO992_RS01405	COG3039	Transposase
BO992_RS01410	COG0676	glucose-6-phosphate 1-epimerase activity
BO992_RS01480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BO992_RS01505	COG2853	Lipoprotein
BO992_RS01520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BO992_RS01525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BO992_RS01530	COG1127	ABC transporter
BO992_RS01605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO992_RS01620	COG3265	gluconokinase activity
BO992_RS01625	COG2211	Major facilitator Superfamily
BO992_RS01630	COG3459	Glycosyltransferase 36 associated
BO992_RS01640	COG2205	protein histidine kinase activity
BO992_RS01650	COG1414	Transcriptional regulator
BO992_RS01655	COG0738	Major facilitator superfamily
BO992_RS01660	COG3254	rhamnose metabolic process
BO992_RS01690	COG0339	signal peptide processing
BO992_RS01720	COG0564	pseudouridine synthase activity
BO992_RS01730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BO992_RS01830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BO992_RS01840	COG0842	Transport permease protein
BO992_RS01845	COG1131	(ABC) transporter
BO992_RS01850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BO992_RS01870	COG1476	TRANSCRIPTIONal
BO992_RS01880	COG4555	ABC transporter
BO992_RS01920	COG0625	glutathione transferase activity
BO992_RS01970	COG0583	DNA-binding transcription factor activity
BO992_RS02005	COG1199	ATP-dependent helicase activity
BO992_RS02025	COG1566	PFAM secretion protein HlyD family protein
BO992_RS02055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BO992_RS02095	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BO992_RS02095	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BO992_RS02100	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BO992_RS02115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BO992_RS02155	COG3237	CsbD-like
BO992_RS02160	COG0180	Tryptophanyl-tRNA synthetase
BO992_RS02165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BO992_RS02215	COG0753	catalase activity
BO992_RS02220	COG1595	DNA-templated transcription, initiation
BO992_RS02230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BO992_RS02240	COG0628	permease
BO992_RS02255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BO992_RS02260	COG1040	competence protein
BO992_RS02265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BO992_RS02270	COG0156	8-amino-7-oxononanoate synthase activity
BO992_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS02300	COG0463	Glycosyl transferase, family 2
BO992_RS02310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BO992_RS02315	COG3100	YcgL domain-containing protein
BO992_RS02330	COG3387	PFAM Glycoside hydrolase 15-related
BO992_RS02340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BO992_RS02360	COG2239	Acts as a magnesium transporter
BO992_RS02375	COG0045	succinate-CoA ligase (ADP-forming) activity
BO992_RS02375	COG1042	CoA-binding domain protein
BO992_RS02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BO992_RS02385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BO992_RS02395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BO992_RS02430	COG3485	protocatechuate 3,4-dioxygenase
BO992_RS02435	COG3485	protocatechuate 3,4-dioxygenase
BO992_RS02450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BO992_RS02455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BO992_RS02485	COG4221	oxidoreductase activity
BO992_RS02510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BO992_RS02535	COG0463	Glycosyl transferase, family 2
BO992_RS02550	COG1475	DNA binding
BO992_RS02555	COG1192	Involved in chromosome partitioning
BO992_RS02570	COG0708	Exodeoxyribonuclease III
BO992_RS02575	COG2211	Major facilitator Superfamily
BO992_RS02590	COG0739	heme binding
BO992_RS02640	COG0745	RESPONSE REGULATOR receiver
BO992_RS02680	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BO992_RS02705	COG2814	Major facilitator Superfamily
BO992_RS02720	COG1289	transmembrane transporter activity
BO992_RS02730	COG1136	(ABC) transporter
BO992_RS02730	COG0577	efflux transmembrane transporter activity
BO992_RS02735	COG0151	Belongs to the GarS family
BO992_RS02745	COG0419	ATPase involved in DNA repair
BO992_RS02760	COG2267	carboxylic ester hydrolase activity
BO992_RS02765	COG2267	carboxylic ester hydrolase activity
BO992_RS02770	COG2267	carboxylic ester hydrolase activity
BO992_RS02790	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BO992_RS02850	COG0439	Biotin carboxylase
BO992_RS02860	COG0511	ligase activity, forming carbon-carbon bonds
BO992_RS02865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BO992_RS02885	COG1324	tolerance protein
BO992_RS02920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BO992_RS02945	COG0534	Mate efflux family protein
BO992_RS02950	COG0616	signal peptide processing
BO992_RS02960	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS02975	COG0009	L-threonylcarbamoyladenylate synthase
BO992_RS02980	COG1754	DNA topoisomerase type I activity
BO992_RS02980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BO992_RS02995	COG2922	Belongs to the Smg family
BO992_RS03000	COG0758	DNA mediated transformation
BO992_RS03005	COG1652	LysM domain
BO992_RS03010	COG0242	peptide deformylase activity
BO992_RS03015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BO992_RS03020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BO992_RS03020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BO992_RS03070	COG1560	Kdo2-lipid A biosynthetic process
BO992_RS03080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BO992_RS03240	COG1294	oxidase, subunit
BO992_RS03245	COG1271	oxidase subunit
BO992_RS03260	COG2204	response regulator
BO992_RS03290	COG2972	Histidine kinase
BO992_RS03305	COG0531	amino acid
BO992_RS03325	COG3590	peptidase
BO992_RS03340	COG0667	Aldo Keto reductase
BO992_RS03355	COG3384	dioxygenase
BO992_RS03365	COG1573	uracil-dna glycosylase
BO992_RS03375	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BO992_RS03385	COG0025	NhaP-type Na H and K H
BO992_RS03390	COG1131	(ABC) transporter
BO992_RS03395	COG0842	Transport permease protein
BO992_RS03410	COG1404	Belongs to the peptidase S8 family
BO992_RS03425	COG0745	RESPONSE REGULATOR receiver
BO992_RS03475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO992_RS03500	COG2202	Pas domain
BO992_RS03500	COG2205	protein histidine kinase activity
BO992_RS03530	COG2813	Specifically methylates the guanine in position
BO992_RS03535	COG1187	pseudouridine synthase activity
BO992_RS03540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BO992_RS03575	COG0697	spore germination
BO992_RS03585	COG2011	ABC-type metal ion transport system permease component
BO992_RS03615	COG0508	dehydrogenase complex catalyzes the overall conversion of
BO992_RS03625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BO992_RS03645	COG0356	it plays a direct role in the translocation of protons across the membrane
BO992_RS03655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BO992_RS03665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BO992_RS03670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BO992_RS03675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BO992_RS03730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO992_RS03735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BO992_RS03790	COG0339	signal peptide processing
BO992_RS03830	COG1956	GAF domain-containing protein
BO992_RS03835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BO992_RS03845	COG0720	synthase
BO992_RS03855	COG0513	Belongs to the DEAD box helicase family
BO992_RS03900	COG0626	cystathionine gamma-synthase activity
BO992_RS03950	COG3328	transposase activity
BO992_RS03975	COG2086	electron transfer activity
BO992_RS04000	COG0662	Cupin 2, conserved barrel domain protein
BO992_RS04000	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BO992_RS04005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BO992_RS04045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BO992_RS04045	COG3218	ABC-type transport auxiliary lipoprotein component
BO992_RS04050	COG1127	ABC transporter
BO992_RS04055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BO992_RS04070	COG0442	prolyl-tRNA aminoacylation
BO992_RS04080	COG1183	phosphatidylcholine synthase activity
BO992_RS04110	COG3039	Transposase
BO992_RS04180	COG0525	valine-tRNA ligase activity
BO992_RS04195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BO992_RS04205	COG0795	lipopolysaccharide-transporting ATPase activity
BO992_RS04220	COG4974	Belongs to the 'phage' integrase family
BO992_RS04225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BO992_RS04230	COG0047	phosphoribosylformylglycinamidine synthase activity
BO992_RS04230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BO992_RS04240	COG5295	Hep Hag repeat protein
BO992_RS04260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BO992_RS04270	COG1459	type II secretion system
BO992_RS04275	COG2165	general secretion pathway protein
BO992_RS04280	COG4970	Tfp pilus assembly protein FimT
BO992_RS04285	COG2165	general secretion pathway protein
BO992_RS04290	COG4795	General secretion pathway protein
BO992_RS04295	COG3156	type II secretion system protein K
BO992_RS04300	COG3166	PFAM Fimbrial assembly family protein
BO992_RS04315	COG1450	Type ii and iii secretion system protein
BO992_RS04330	COG2188	Transcriptional regulator
BO992_RS04385	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BO992_RS04390	COG1518	maintenance of DNA repeat elements
BO992_RS04435	COG1399	metal-binding, possibly nucleic acid-binding protein
BO992_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS04465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BO992_RS04475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BO992_RS04480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BO992_RS04515	COG3829	transcription factor binding
BO992_RS04550	COG3039	Transposase
BO992_RS04605	COG2826	transposase and inactivated derivatives, IS30 family
BO992_RS04615	COG0678	peroxiredoxin activity
BO992_RS04635	COG0330	HflC and HflK could
BO992_RS04640	COG0330	HflC and HflK could
BO992_RS04655	COG0308	aminopeptidase N
BO992_RS04705	COG1560	Kdo2-lipid A biosynthetic process
BO992_RS04710	COG1519	Transferase
BO992_RS04715	COG1538	Outer membrane efflux protein
BO992_RS04720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BO992_RS04745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BO992_RS04750	COG0066	3-isopropylmalate dehydratase activity
BO992_RS04785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BO992_RS04795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BO992_RS04800	COG3710	Transcriptional regulator
BO992_RS04825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BO992_RS04845	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BO992_RS04875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BO992_RS04885	COG3781	membrane
BO992_RS04905	COG0625	glutathione transferase activity
BO992_RS04915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BO992_RS04920	COG1217	gtp-binding protein TYPA
BO992_RS04940	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BO992_RS05080	COG3039	Transposase
BO992_RS05105	COG0584	glycerophosphoryl diester phosphodiesterase
BO992_RS05130	COG0473	3-isopropylmalate dehydrogenase activity
BO992_RS05185	COG0544	peptidyl-prolyl cis-trans isomerase activity
BO992_RS05225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BO992_RS05250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BO992_RS05260	COG0631	protein serine/threonine phosphatase activity
BO992_RS05345	COG0582	viral genome integration into host DNA
BO992_RS05355	COG0859	PFAM glycosyl transferase family 9
BO992_RS05360	COG3642	lipopolysaccharide core region biosynthetic process
BO992_RS05365	COG1234	tRNA 3'-trailer cleavage
BO992_RS05370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BO992_RS05380	COG0315	cyclic pyranopterin monophosphate synthase activity
BO992_RS05385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BO992_RS05390	COG0314	molybdopterin synthase activity
BO992_RS05420	COG0537	adenosine 5'-monophosphoramidase activity
BO992_RS05440	COG0714	Associated with various cellular activities
BO992_RS05460	COG0242	peptide deformylase activity
BO992_RS05510	COG3039	Transposase
BO992_RS05540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BO992_RS05545	COG0726	polysaccharide deacetylase
BO992_RS05595	COG2211	Major facilitator Superfamily
BO992_RS05605	COG1609	Transcriptional regulator
BO992_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS05615	COG2851	Citrate transporter
BO992_RS05635	COG0642	Histidine kinase
BO992_RS05645	COG2197	response regulator
BO992_RS05665	COG0583	DNA-binding transcription factor activity
BO992_RS05680	COG4191	Histidine kinase
BO992_RS05700	COG0281	malic enzyme
BO992_RS05700	COG0280	phosphate acetyltransferase
BO992_RS05735	COG0352	thiamine-phosphate diphosphorylase activity
BO992_RS05740	COG1773	rubredoxin
BO992_RS05745	COG2912	Transglutaminase-like superfamily
BO992_RS05765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BO992_RS05790	COG0006	proline dipeptidase activity
BO992_RS05825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BO992_RS05840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BO992_RS05845	COG1561	YicC-like family, N-terminal region
BO992_RS05870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BO992_RS05880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BO992_RS05905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BO992_RS05955	COG0714	Associated with various cellular activities
BO992_RS05975	COG2304	oxidoreductase activity
BO992_RS05995	COG1301	dicarboxylic acid transport
BO992_RS06000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BO992_RS06010	COG0739	heme binding
BO992_RS06015	COG1376	ErfK ybiS ycfS ynhG family protein
BO992_RS06040	COG1022	Amp-dependent synthetase and ligase
BO992_RS06050	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS06065	COG0642	Histidine kinase
BO992_RS06085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BO992_RS06090	COG4149	molybdate abc transporter
BO992_RS06095	COG0725	ABC transporter, periplasmic molybdate-binding protein
BO992_RS06100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BO992_RS06100	COG3453	Protein conserved in bacteria
BO992_RS06130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BO992_RS06150	COG2205	protein histidine kinase activity
BO992_RS06155	COG0745	RESPONSE REGULATOR receiver
BO992_RS06205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BO992_RS06210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BO992_RS06300	COG2201	protein-glutamate methylesterase activity
BO992_RS06350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BO992_RS06365	COG1842	Phage shock protein A
BO992_RS06390	COG0754	glutathionylspermidine amidase activity
BO992_RS06460	COG0531	amino acid
BO992_RS06465	COG2197	response regulator
BO992_RS06480	COG1113	amino acid transport
BO992_RS06500	COG1271	oxidase subunit
BO992_RS06505	COG1294	oxidase, subunit
BO992_RS06515	COG2239	Acts as a magnesium transporter
BO992_RS06525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BO992_RS06530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BO992_RS06540	COG1660	Displays ATPase and GTPase activities
BO992_RS06545	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BO992_RS06550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BO992_RS06565	COG1137	ATPase activity
BO992_RS06570	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BO992_RS06580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BO992_RS06590	COG0271	Belongs to the BolA IbaG family
BO992_RS06600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BO992_RS06620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BO992_RS06635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BO992_RS06645	COG0628	permease
BO992_RS06655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BO992_RS06660	COG3178	'Phosphotransferase
BO992_RS06675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BO992_RS06680	COG1555	photosystem II stabilization
BO992_RS06725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BO992_RS06740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BO992_RS06765	COG0228	four-way junction DNA binding
BO992_RS06770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BO992_RS06775	COG0336	Belongs to the RNA methyltransferase TrmD family
BO992_RS06790	COG0534	Mate efflux family protein
BO992_RS06830	COG0542	response to heat
BO992_RS06870	COG4206	TonB-dependent receptor
BO992_RS06930	COG0019	diaminopimelate decarboxylase activity
BO992_RS06940	COG2814	Major facilitator Superfamily
BO992_RS06945	COG4264	IucA IucC family
BO992_RS06955	COG4772	TonB-dependent receptor
BO992_RS06970	COG4651	solute:proton antiporter activity
BO992_RS06970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BO992_RS07005	COG0488	(ABC) transporter
BO992_RS07030	COG0657	acetylesterase activity
BO992_RS07030	COG2755	lipolytic protein G-D-S-L family
BO992_RS07055	COG2207	Transcriptional regulator
BO992_RS07060	COG0326	Molecular chaperone. Has ATPase activity
BO992_RS07090	COG3328	transposase activity
BO992_RS07095	COG0174	glutamine synthetase
BO992_RS07100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BO992_RS07110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BO992_RS07125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BO992_RS07160	COG2146	nitrite reductase [NAD(P)H] activity
BO992_RS07170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BO992_RS07175	COG0719	Fe-S assembly protein
BO992_RS07180	COG0396	ATPase activity
BO992_RS07185	COG0719	Fe-S assembly protein
BO992_RS07190	COG1959	2 iron, 2 sulfur cluster binding
BO992_RS07210	COG0693	protein deglycase activity
BO992_RS07255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BO992_RS07290	COG0519	Catalyzes the synthesis of GMP from XMP
BO992_RS07300	COG1678	Uncharacterized ACR, COG1678
BO992_RS07305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BO992_RS07320	COG1764	response to oxidative stress
BO992_RS07330	COG0384	phenazine biosynthesis protein PhzF
BO992_RS07340	COG0527	aspartate kinase activity
BO992_RS07370	COG0142	geranyltranstransferase activity
BO992_RS07375	COG0629	single-stranded DNA binding
BO992_RS07380	COG5001	Diguanylate cyclase
BO992_RS07380	COG4251	negative regulation of phosphorylation
BO992_RS07380	COG2203	Gaf domain
BO992_RS07380	COG3706	GGDEF domain
BO992_RS07420	COG2879	small protein
BO992_RS07425	COG1966	Carbon starvation protein
BO992_RS07430	COG1741	Belongs to the pirin family
BO992_RS07545	COG1741	Belongs to the pirin family
BO992_RS07555	COG1515	deoxyribonuclease V activity
BO992_RS07575	COG3590	peptidase
BO992_RS07590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BO992_RS07595	COG2202	Pas domain
BO992_RS07595	COG2200	EAL domain
BO992_RS07595	COG2199	diguanylate cyclase activity
BO992_RS07600	COG0835	chemotaxis
BO992_RS07605	COG0840	transmembrane signaling receptor activity
BO992_RS07610	COG0643	Histidine kinase
BO992_RS07610	COG2198	Histidine kinase
BO992_RS07625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BO992_RS07635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BO992_RS07655	COG2205	protein histidine kinase activity
BO992_RS07670	COG3039	Transposase
BO992_RS07690	COG3039	Transposase
BO992_RS07715	COG3039	Transposase
BO992_RS07735	COG3039	Transposase
BO992_RS07765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BO992_RS07770	COG0735	belongs to the Fur family
BO992_RS07830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BO992_RS07835	COG0084	hydrolase, TatD family'
BO992_RS07850	COG1960	acyl-CoA dehydrogenase activity
BO992_RS07865	COG0367	asparagine synthase
BO992_RS07875	COG0305	Participates in initiation and elongation during chromosome replication
BO992_RS07880	COG0415	Belongs to the DNA photolyase family
BO992_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS07945	COG3039	Transposase
BO992_RS08005	COG5001	Diguanylate cyclase
BO992_RS08005	COG5002	protein histidine kinase activity
BO992_RS08010	COG1187	pseudouridine synthase activity
BO992_RS08035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BO992_RS08045	COG0475	glutathione-regulated potassium exporter activity
BO992_RS08050	COG5000	phosphorelay sensor kinase activity
BO992_RS08050	COG5002	protein histidine kinase activity
BO992_RS08055	COG0745	RESPONSE REGULATOR receiver
BO992_RS08085	COG1132	(ABC) transporter
BO992_RS08115	COG3039	Transposase
BO992_RS08140	COG3039	Transposase
BO992_RS08185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BO992_RS08195	COG4969	Belongs to the N-Me-Phe pilin family
BO992_RS08200	COG2194	sulfuric ester hydrolase activity
BO992_RS08240	COG0045	succinate-CoA ligase (ADP-forming) activity
BO992_RS08245	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BO992_RS08260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BO992_RS08260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BO992_RS08265	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO992_RS08270	COG0564	pseudouridine synthase activity
BO992_RS08295	COG3387	PFAM Glycoside hydrolase 15-related
BO992_RS08300	COG1877	trehalose-phosphatase activity
BO992_RS08340	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BO992_RS08360	COG1595	DNA-templated transcription, initiation
BO992_RS08370	COG1946	Acyl-CoA thioesterase
BO992_RS08385	COG0824	Thioesterase
BO992_RS08390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BO992_RS08400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BO992_RS08405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BO992_RS08410	COG0268	Binds directly to 16S ribosomal RNA
BO992_RS08415	COG0728	peptidoglycan biosynthetic process
BO992_RS08420	COG0196	riboflavin kinase activity
BO992_RS08430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BO992_RS08435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BO992_RS08450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BO992_RS08455	COG1845	cytochrome c oxidase, subunit III
BO992_RS08460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BO992_RS08480	COG3209	COG3209 Rhs family protein
BO992_RS08480	COG3209	COG3209 Rhs family protein
BO992_RS08605	COG0632	four-way junction helicase activity
BO992_RS08615	COG2255	four-way junction helicase activity
BO992_RS08620	COG0824	Thioesterase
BO992_RS08630	COG0848	biopolymer transport protein
BO992_RS08645	COG2885	chlorophyll binding
BO992_RS08655	COG0602	queuosine metabolic process
BO992_RS08665	COG1187	pseudouridine synthase activity
BO992_RS08725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BO992_RS08750	COG0514	ATP-dependent DNA helicase (RecQ)
BO992_RS08760	COG0783	Belongs to the Dps family
BO992_RS08765	COG1643	Atp-dependent helicase
BO992_RS08820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BO992_RS08830	COG1215	transferase activity, transferring glycosyl groups
BO992_RS08835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BO992_RS08845	COG1199	ATP-dependent helicase activity
BO992_RS08855	COG1397	ADP-ribosylglycohydrolase
BO992_RS08865	COG0189	ligase activity
BO992_RS08880	COG0835	chemotaxis
BO992_RS08885	COG0840	transmembrane signaling receptor activity
BO992_RS08890	COG0643	Histidine kinase
BO992_RS08890	COG0784	Response regulator, receiver
BO992_RS08890	COG2198	Histidine kinase
BO992_RS08935	COG1446	asparaginase
BO992_RS08940	COG3142	Participates in the control of copper homeostasis
BO992_RS08995	COG3537	Alpha-1,2-mannosidase
BO992_RS09065	COG1472	Belongs to the glycosyl hydrolase 3 family
BO992_RS09085	COG3858	chitin binding
BO992_RS09085	COG1388	LysM domain
BO992_RS09100	COG0837	glucose binding
BO992_RS09105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BO992_RS09115	COG0494	nUDIX hydrolase
BO992_RS09125	COG3956	TIGRFAM MazG family protein
BO992_RS09130	COG1742	UPF0060 membrane protein
BO992_RS09140	COG0330	HflC and HflK could
BO992_RS09155	COG0509	glycine decarboxylation via glycine cleavage system
BO992_RS09190	COG1960	acyl-CoA dehydrogenase activity
BO992_RS09200	COG1309	transcriptional regulator
BO992_RS09205	COG4771	TonB-dependent receptor
BO992_RS09215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BO992_RS09225	COG0463	Glycosyl transferase, family 2
BO992_RS09245	COG1272	protein, Hemolysin III
BO992_RS09255	COG0739	heme binding
BO992_RS09260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BO992_RS09265	COG0626	cystathionine gamma-synthase activity
BO992_RS09275	COG1760	l-serine dehydratase
BO992_RS09290	COG2353	YceI-like domain
BO992_RS09300	COG2353	YceI-like domain
BO992_RS09350	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BO992_RS09370	COG1960	acyl-CoA dehydrogenase activity
BO992_RS09375	COG1024	Enoyl-CoA hydratase
BO992_RS09395	COG1024	Enoyl-CoA hydratase
BO992_RS09395	COG1250	3-hydroxyacyl-CoA dehydrogenase
BO992_RS09410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BO992_RS09440	COG1381	Involved in DNA repair and RecF pathway recombination
BO992_RS09455	COG2954	triphosphatase activity
BO992_RS09470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BO992_RS09475	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BO992_RS09480	COG3046	protein related to deoxyribodipyrimidine photolyase
BO992_RS09490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BO992_RS09495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BO992_RS09500	COG1278	Cold shock
BO992_RS09520	COG1201	RNA secondary structure unwinding
BO992_RS09525	COG1793	dna ligase
BO992_RS09535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BO992_RS09535	COG1793	dna ligase
BO992_RS09565	COG0183	Belongs to the thiolase family
BO992_RS09590	COG1451	nucleotide metabolic process
BO992_RS09605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BO992_RS09650	COG1047	Peptidyl-prolyl cis-trans
BO992_RS09665	COG2824	Alkylphosphonate utilization operon protein PhnA
BO992_RS09680	COG1902	pentaerythritol trinitrate reductase activity
BO992_RS09685	COG2814	Major facilitator Superfamily
BO992_RS09740	COG0392	lysyltransferase activity
BO992_RS09740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BO992_RS09750	COG0251	oxidation-reduction process
BO992_RS09755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BO992_RS09770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BO992_RS09795	COG1595	DNA-templated transcription, initiation
BO992_RS09815	COG2878	Part of a membrane complex involved in electron transport
BO992_RS09825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BO992_RS09825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BO992_RS09845	COG0833	amino acid
BO992_RS09850	COG2040	homocysteine
BO992_RS09865	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BO992_RS09905	COG0529	Catalyzes the synthesis of activated sulfate
BO992_RS09905	COG2895	sulfate adenylyltransferase (ATP) activity
BO992_RS09950	COG1981	membrane
BO992_RS09975	COG1131	(ABC) transporter
BO992_RS09980	COG4771	TonB-dependent receptor
BO992_RS09990	COG0825	malonyl-CoA metabolic process
BO992_RS10010	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BO992_RS10015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BO992_RS10035	COG0750	zinc metalloprotease
BO992_RS10045	COG0575	Belongs to the CDS family
BO992_RS10055	COG0233	cytoplasmic translational termination
BO992_RS10070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BO992_RS10130	COG1393	Belongs to the ArsC family
BO992_RS10145	COG0367	asparagine synthase
BO992_RS10155	COG4774	siderophore transport
BO992_RS10195	COG1566	PFAM secretion protein HlyD family protein
BO992_RS10200	COG2814	Major facilitator Superfamily
BO992_RS10245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BO992_RS10255	COG1960	acyl-CoA dehydrogenase activity
BO992_RS10280	COG2914	Belongs to the UPF0125 (RnfH) family
BO992_RS10290	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO992_RS10300	COG0497	DNA recombination
BO992_RS10310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BO992_RS10315	COG0443	Heat shock 70 kDa protein
BO992_RS10320	COG0484	heat shock protein binding
BO992_RS10330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BO992_RS10335	COG1605	Chorismate mutase
BO992_RS10335	COG0287	Prephenate dehydrogenase
BO992_RS10355	COG0583	DNA-binding transcription factor activity
BO992_RS10370	COG1132	(ABC) transporter
BO992_RS10405	COG2850	peptidyl-arginine hydroxylation
BO992_RS10485	COG1131	(ABC) transporter
BO992_RS10490	COG1725	Transcriptional regulator
BO992_RS10500	COG0386	Belongs to the glutathione peroxidase family
BO992_RS10515	COG2900	Belongs to the SlyX family
BO992_RS10530	COG1609	Transcriptional regulator
BO992_RS10540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO992_RS10550	COG1410	methionine synthase
BO992_RS10550	COG0646	methionine synthase
BO992_RS10555	COG0646	methionine synthase
BO992_RS10555	COG1410	methionine synthase
BO992_RS10560	COG2226	methyltransferase
BO992_RS10565	COG1960	acyl-CoA dehydrogenase activity
BO992_RS10595	COG0557	exoribonuclease II activity
BO992_RS10615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BO992_RS10630	COG3039	Transposase
BO992_RS10655	COG3328	transposase activity
BO992_RS10665	COG1278	Cold shock
BO992_RS10680	COG3039	Transposase
BO992_RS10685	COG3039	Transposase
BO992_RS10735	COG3039	Transposase
BO992_RS10745	COG0583	DNA-binding transcription factor activity
BO992_RS10805	COG2201	protein-glutamate methylesterase activity
BO992_RS10840	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BO992_RS10850	COG0531	amino acid
BO992_RS10855	COG0531	amino acid
BO992_RS10865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BO992_RS10870	COG0277	FAD linked oxidase domain protein
BO992_RS10935	COG0436	Aminotransferase
BO992_RS10960	COG1187	pseudouridine synthase activity
BO992_RS10965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BO992_RS10970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BO992_RS10975	COG2350	Protein conserved in bacteria
BO992_RS11005	COG1175	transmembrane transport
BO992_RS11010	COG0395	ABC-type sugar transport system, permease component
BO992_RS11035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BO992_RS11045	COG2957	Belongs to the agmatine deiminase family
BO992_RS11060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BO992_RS11065	COG0539	negative regulation of cytoplasmic translation
BO992_RS11070	COG0776	regulation of translation
BO992_RS11080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BO992_RS11085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BO992_RS11095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BO992_RS11115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BO992_RS11130	COG3002	Belongs to the UPF0753 family
BO992_RS11135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BO992_RS11140	COG0583	DNA-binding transcription factor activity
BO992_RS11170	COG0583	DNA-binding transcription factor activity
BO992_RS11195	COG1914	H( )-stimulated, divalent metal cation uptake system
BO992_RS11215	COG0668	transmembrane transport
BO992_RS11255	COG3039	Transposase
BO992_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS11280	COG1183	phosphatidylcholine synthase activity
BO992_RS11290	COG3243	poly(R)-hydroxyalkanoic acid synthase
BO992_RS11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO992_RS11305	COG0723	plastoquinol--plastocyanin reductase activity
BO992_RS11315	COG2183	response to ionizing radiation
BO992_RS11330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BO992_RS11345	COG0671	phosphoesterase, PA-phosphatase related
BO992_RS11370	COG1794	racemase activity, acting on amino acids and derivatives
BO992_RS11380	COG0697	spore germination
BO992_RS11405	COG1012	belongs to the aldehyde dehydrogenase family
BO992_RS11440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BO992_RS11460	COG0124	histidyl-tRNA synthetase
BO992_RS11480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BO992_RS11495	COG0131	Imidazoleglycerol-phosphate dehydratase
BO992_RS11495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BO992_RS11505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BO992_RS11515	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BO992_RS11515	COG0140	phosphoribosyl-ATP diphosphatase activity
BO992_RS11555	COG0653	protein targeting
BO992_RS11710	COG2201	protein-glutamate methylesterase activity
BO992_RS11720	COG2801	Transposase and inactivated derivatives
BO992_RS11740	COG3039	Transposase
BO992_RS11765	COG3328	transposase activity
BO992_RS11800	COG0322	excinuclease ABC activity
BO992_RS11810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BO992_RS11820	COG1663	tetraacyldisaccharide 4'-kinase activity
BO992_RS11835	COG0811	peptide transport
BO992_RS11860	COG4591	ABC-type transport system involved in lipoprotein release permease component
BO992_RS11875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BO992_RS11890	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BO992_RS11905	COG0354	folic acid binding
BO992_RS11920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BO992_RS11930	COG0363	glucosamine-6-phosphate deaminase activity
BO992_RS11935	COG0129	dihydroxy-acid dehydratase activity
BO992_RS11940	COG0800	Aldolase
BO992_RS11970	COG2205	protein histidine kinase activity
BO992_RS11970	COG5002	protein histidine kinase activity
BO992_RS11970	COG0784	Response regulator, receiver
BO992_RS12055	COG0386	Belongs to the glutathione peroxidase family
BO992_RS12145	COG3706	GGDEF domain
BO992_RS12145	COG2203	Gaf domain
BO992_RS12145	COG5001	Diguanylate cyclase
BO992_RS12145	COG4251	negative regulation of phosphorylation
BO992_RS12165	COG1472	Belongs to the glycosyl hydrolase 3 family
BO992_RS12215	COG0617	tRNA 3'-terminal CCA addition
BO992_RS12225	COG1469	GTP cyclohydrolase I activity
BO992_RS12230	COG0860	N-Acetylmuramoyl-L-alanine amidase
BO992_RS12285	COG4566	intracellular signal transduction
BO992_RS12325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BO992_RS12330	COG0077	Prephenate dehydratase
BO992_RS12330	COG1605	Chorismate mutase
BO992_RS12340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BO992_RS12385	COG1228	amidohydrolase
BO992_RS12390	COG2986	histidine ammonia-lyase
BO992_RS12400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BO992_RS12425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BO992_RS12440	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BO992_RS12455	COG3115	cell septum assembly
BO992_RS12465	COG0359	binds to the 23S rRNA
BO992_RS12475	COG0360	Binds together with S18 to 16S ribosomal RNA
BO992_RS12480	COG0316	Belongs to the HesB IscA family
BO992_RS12515	COG0288	reversible hydration of carbon dioxide
BO992_RS12540	COG2925	Exonuclease
BO992_RS12550	COG0667	Aldo Keto reductase
BO992_RS12575	COG0116	Belongs to the methyltransferase superfamily
BO992_RS12575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BO992_RS12620	COG0494	nUDIX hydrolase
BO992_RS12630	COG1024	Enoyl-CoA hydratase
BO992_RS12640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BO992_RS12655	COG3039	Transposase
BO992_RS12695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BO992_RS12700	COG0573	inorganic phosphate transmembrane transporter activity
BO992_RS12715	COG0704	Plays a role in the regulation of phosphate uptake
BO992_RS12725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BO992_RS12740	COG3328	transposase activity
BO992_RS12775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BO992_RS12780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BO992_RS12785	COG1862	Preprotein translocase
BO992_RS12790	COG0343	queuine tRNA-ribosyltransferase activity
BO992_RS12875	COG0405	Gamma-glutamyltransferase
BO992_RS12880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BO992_RS12895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BO992_RS12900	COG0742	ribosomal rna small subunit methyltransferase
BO992_RS12920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BO992_RS12950	COG3039	Transposase
BO992_RS12960	COG3039	Transposase
BO992_RS12990	COG0303	'Molybdopterin
BO992_RS13000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO992_RS13010	COG1426	Protein conserved in bacteria
BO992_RS13020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BO992_RS13035	COG1024	Enoyl-CoA hydratase
BO992_RS13035	COG1250	3-hydroxyacyl-CoA dehydrogenase
BO992_RS13040	COG0183	Belongs to the thiolase family
BO992_RS13045	COG0038	chloride channel
BO992_RS13065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BO992_RS13090	COG1674	ftsk spoiiie
BO992_RS13095	COG0492	ferredoxin-NADP+ reductase activity
BO992_RS13120	COG0542	response to heat
BO992_RS13135	COG0482	sulfurtransferase activity
BO992_RS13160	COG5001	Diguanylate cyclase
BO992_RS13165	COG4585	Histidine kinase
BO992_RS13175	COG5002	protein histidine kinase activity
BO992_RS13195	COG0835	chemotaxis
BO992_RS13195	COG0784	Response regulator, receiver
BO992_RS13205	COG1558	bacterial-type flagellum-dependent cell motility
BO992_RS13210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BO992_RS13220	COG4787	bacterial-type flagellum-dependent cell motility
BO992_RS13260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BO992_RS13265	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BO992_RS13295	COG2201	protein-glutamate methylesterase activity
BO992_RS13315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BO992_RS13325	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS13360	COG1677	Flagellar hook-basal body complex protein FliE
BO992_RS13410	COG3190	flagellar
BO992_RS13430	COG1684	flagellar biosynthetic protein fliR
BO992_RS13485	COG0643	Histidine kinase
BO992_RS13485	COG0784	Response regulator, receiver
BO992_RS13485	COG2198	Histidine kinase
BO992_RS13525	COG3039	Transposase
BO992_RS13605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BO992_RS13610	COG4988	ABC transporter
BO992_RS13635	COG1271	oxidase subunit
BO992_RS13670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BO992_RS13690	COG0165	Argininosuccinate lyase
BO992_RS13705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BO992_RS13710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BO992_RS13720	COG0137	argininosuccinate synthase activity
BO992_RS13725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BO992_RS13740	COG2166	iron-sulfur cluster assembly
BO992_RS13765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BO992_RS13805	COG3039	Transposase
BO992_RS13820	COG4677	pectinesterase activity
BO992_RS13845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BO992_RS13850	COG0402	S-adenosylhomocysteine deaminase activity
BO992_RS13865	COG1509	lysine 2,3-aminomutase activity
BO992_RS13870	COG5001	Diguanylate cyclase
BO992_RS13870	COG3300	MHYT domain
BO992_RS13885	COG0483	inositol monophosphate 1-phosphatase activity
BO992_RS13890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BO992_RS13915	COG0488	(ABC) transporter
BO992_RS13920	COG0513	Belongs to the DEAD box helicase family
BO992_RS13940	COG0625	glutathione transferase activity
BO992_RS13950	COG1671	Belongs to the UPF0178 family
BO992_RS13955	COG4681	YaeQ
BO992_RS13960	COG2081	HI0933 family
BO992_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS14005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BO992_RS14010	COG0860	N-Acetylmuramoyl-L-alanine amidase
BO992_RS14015	COG0802	atpase or kinase
BO992_RS14020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BO992_RS14020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BO992_RS14025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BO992_RS14050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BO992_RS14135	COG3328	transposase activity
BO992_RS14180	COG2969	positive regulation of protein catabolic process
BO992_RS14185	COG0625	glutathione transferase activity
BO992_RS14190	COG2857	Cytochrome c1
BO992_RS14195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BO992_RS14200	COG0723	plastoquinol--plastocyanin reductase activity
BO992_RS14210	COG0741	lytic transglycosylase activity
BO992_RS14235	COG1702	phosphate starvation-inducible protein PhoH
BO992_RS14255	COG4535	Mg2 and Co2 transporter CorC
BO992_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
BO992_RS14280	COG1177	transmembrane transport
BO992_RS14290	COG3842	ATPase activity
BO992_RS14330	COG0174	glutamine synthetase
BO992_RS14335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO992_RS14345	COG0477	Major facilitator Superfamily
BO992_RS14355	COG0243	molybdopterin cofactor binding
BO992_RS14365	COG2223	nitrite transmembrane transporter activity
BO992_RS14385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BO992_RS14390	COG1121	(ABC) transporter
BO992_RS14400	COG2733	membrane
BO992_RS14405	COG5002	protein histidine kinase activity
BO992_RS14405	COG2205	protein histidine kinase activity
BO992_RS14405	COG0784	Response regulator, receiver
BO992_RS14415	COG3039	Transposase
BO992_RS14425	COG2902	Dehydrogenase
BO992_RS14435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO992_RS14440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO992_RS14460	COG1609	Transcriptional regulator
BO992_RS14465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BO992_RS14465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BO992_RS14470	COG1105	Belongs to the carbohydrate kinase PfkB family
BO992_RS14475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BO992_RS14475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BO992_RS14490	COG3039	Transposase
BO992_RS14500	COG3039	Transposase
BO992_RS14625	COG3039	Transposase
BO992_RS14655	COG4771	TonB-dependent receptor
BO992_RS14665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BO992_RS14685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BO992_RS14690	COG1360	Flagellar Motor Protein
BO992_RS14700	COG0835	chemotaxis
BO992_RS14710	COG0745	RESPONSE REGULATOR receiver
BO992_RS14735	COG0840	transmembrane signaling receptor activity
BO992_RS14750	COG0840	transmembrane signaling receptor activity
BO992_RS14760	COG0840	transmembrane signaling receptor activity
BO992_RS14770	COG0840	transmembrane signaling receptor activity
BO992_RS14775	COG0840	transmembrane signaling receptor activity
BO992_RS14780	COG0840	transmembrane signaling receptor activity
BO992_RS14785	COG0840	transmembrane signaling receptor activity
BO992_RS14805	COG0835	chemotaxis
BO992_RS14830	COG0840	transmembrane signaling receptor activity
BO992_RS14865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BO992_RS14895	COG0318	PFAM AMP-dependent synthetase and ligase
BO992_RS14900	COG1024	Enoyl-CoA hydratase
BO992_RS14905	COG2205	protein histidine kinase activity
BO992_RS14905	COG2198	Histidine kinase
BO992_RS14905	COG0784	Response regulator, receiver
BO992_RS14975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BO992_RS14985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BO992_RS14990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BO992_RS15000	COG0505	Belongs to the CarA family
BO992_RS15005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BO992_RS15015	COG2258	MOSC domain
BO992_RS15020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BO992_RS15070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BO992_RS15090	COG0477	Major facilitator Superfamily
BO992_RS15100	COG1070	Carbohydrate kinase
BO992_RS15110	COG1501	Belongs to the glycosyl hydrolase 31 family
BO992_RS15125	COG0800	Aldolase
BO992_RS15130	COG4948	Mandelate Racemase Muconate Lactonizing
BO992_RS15140	COG3734	2-keto-3-deoxy-galactonokinase
BO992_RS15145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BO992_RS15155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BO992_RS15170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BO992_RS15175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BO992_RS15185	COG0351	phosphomethylpyrimidine kinase
BO992_RS15215	COG0583	DNA-binding transcription factor activity
BO992_RS15220	COG1741	Belongs to the pirin family
BO992_RS15240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BO992_RS15245	COG0305	Participates in initiation and elongation during chromosome replication
BO992_RS15270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BO992_RS15275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BO992_RS15280	COG2137	regulation of response to DNA damage stimulus
BO992_RS15285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BO992_RS15300	COG1546	Belongs to the CinA family
BO992_RS15305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BO992_RS15320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BO992_RS15330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BO992_RS15335	COG1534	Rna-binding protein
BO992_RS15350	COG1238	metal cluster binding
BO992_RS15355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BO992_RS15360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BO992_RS15365	COG2840	Smr protein MutS2
BO992_RS15380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BO992_RS15395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BO992_RS15400	COG0148	phosphopyruvate hydratase activity
BO992_RS15410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BO992_RS15415	COG0504	CTP synthase activity
BO992_RS15440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BO992_RS15445	COG0306	phosphate transporter
BO992_RS15460	COG1253	flavin adenine dinucleotide binding
BO992_RS15475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BO992_RS15495	COG0477	Major facilitator Superfamily
BO992_RS15505	COG1132	(ABC) transporter
BO992_RS15510	COG1136	(ABC) transporter
BO992_RS15530	COG0438	transferase activity, transferring glycosyl groups
BO992_RS15540	COG2264	protein methyltransferase activity
BO992_RS15570	COG2244	polysaccharide biosynthetic process
BO992_RS15620	COG1595	DNA-templated transcription, initiation
BO992_RS15635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BO992_RS15655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BO992_RS15670	COG2201	protein-glutamate methylesterase activity
BO992_RS15690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO992_RS15695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO992_RS15750	COG1858	cytochrome C peroxidase
BO992_RS15790	COG0515	serine threonine protein kinase
BO992_RS15795	COG0631	protein serine/threonine phosphatase activity
BO992_RS15910	COG3039	Transposase
BO992_RS15930	COG3039	Transposase
BO992_RS15975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BO992_RS15975	COG0316	Belongs to the HesB IscA family
BO992_RS15980	COG2154	pterin-4-alpha-carbinolamine dehydratase
BO992_RS15990	COG0428	transporter
BO992_RS15995	COG0428	transporter
BO992_RS16000	COG3064	Membrane
BO992_RS16010	COG1530	ribonuclease E activity
BO992_RS16030	COG1054	Belongs to the UPF0176 family
BO992_RS16035	COG3039	Transposase
BO992_RS16055	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BO992_RS16095	COG3039	Transposase
BO992_RS16100	COG3039	Transposase
BO992_RS16130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BO992_RS16130	COG1648	precorrin-2 dehydrogenase activity
BO992_RS16155	COG0746	molybdenum cofactor guanylyltransferase activity
BO992_RS16230	COG3328	transposase activity
BO992_RS16235	COG4206	TonB-dependent receptor
BO992_RS16270	COG4206	TonB-dependent receptor
BO992_RS16320	COG0531	amino acid
BO992_RS16335	COG0006	proline dipeptidase activity
BO992_RS16345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BO992_RS16360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO992_RS16365	COG3938	Belongs to the proline racemase family
BO992_RS16375	COG0552	protein localization to endoplasmic reticulum
BO992_RS16400	COG0784	Response regulator, receiver
BO992_RS16400	COG4191	Histidine kinase
BO992_RS16490	COG3040	lipid binding
BO992_RS16530	COG0438	transferase activity, transferring glycosyl groups
BO992_RS16540	COG0438	transferase activity, transferring glycosyl groups
BO992_RS16545	COG0438	transferase activity, transferring glycosyl groups
BO992_RS16615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BO992_RS16645	COG0556	nucleotide-excision repair
BO992_RS16650	COG4969	Belongs to the N-Me-Phe pilin family
BO992_RS16690	COG1611	Belongs to the LOG family
BO992_RS16705	COG2095	MarC family integral membrane protein
BO992_RS16715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BO992_RS16750	COG1185	polyribonucleotide nucleotidyltransferase activity
BO992_RS16755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BO992_RS16775	COG0195	Participates in both transcription termination and antitermination
BO992_RS16780	COG0779	Required for maturation of 30S ribosomal subunits
BO992_RS16790	COG1007	ATP synthesis coupled electron transport
BO992_RS16825	COG1034	ATP synthesis coupled electron transport
BO992_RS16830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BO992_RS16835	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BO992_RS16840	COG0649	NAD binding
BO992_RS16845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BO992_RS16855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BO992_RS16870	COG0149	triose-phosphate isomerase activity
BO992_RS16925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BO992_RS16930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BO992_RS16955	COG0135	phosphoribosylanthranilate isomerase activity
BO992_RS16960	COG0101	tRNA pseudouridine synthase activity
BO992_RS16980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BO992_RS16985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BO992_RS16990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BO992_RS16995	COG2890	protein-(glutamine-N5) methyltransferase activity
BO992_RS17050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BO992_RS17060	COG0412	Dienelactone hydrolase
BO992_RS17085	COG0717	Belongs to the dCTP deaminase family
BO992_RS17090	COG0489	protein tyrosine kinase activity
BO992_RS17135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO992_RS17140	COG2311	Membrane
BO992_RS17145	COG1047	Peptidyl-prolyl cis-trans
BO992_RS17150	COG0791	NLP P60 protein
BO992_RS17155	COG0791	NLP P60 protein
BO992_RS17175	COG1301	dicarboxylic acid transport
BO992_RS17180	COG1785	Belongs to the alkaline phosphatase family
BO992_RS17185	COG0037	tRNA processing
BO992_RS17190	COG1722	exodeoxyribonuclease VII activity
BO992_RS17195	COG0142	geranyltranstransferase activity
BO992_RS17220	COG0312	modulator of DNA gyrase
BO992_RS17225	COG3028	Belongs to the UPF0307 family
BO992_RS17230	COG0312	modulator of DNA gyrase
BO992_RS17240	COG3164	Protein of unknown function
BO992_RS17255	COG2968	Membrane
BO992_RS17280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BO992_RS17305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BO992_RS17335	COG3118	belongs to the thioredoxin family
BO992_RS17410	COG3039	Transposase
BO992_RS17415	COG3039	Transposase
BO992_RS17510	COG2022	thiamine diphosphate biosynthetic process
BO992_RS17525	COG0471	metal ion transport
BO992_RS17525	COG3273	potassium ion transport
BO992_RS17555	COG1970	mechanosensitive ion channel activity
BO992_RS17580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BO992_RS17610	COG0308	aminopeptidase N
BO992_RS17615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO992_RS17630	COG2895	sulfate adenylyltransferase (ATP) activity
BO992_RS17630	COG0529	Catalyzes the synthesis of activated sulfate
BO992_RS17635	COG0175	sulfate reduction
BO992_RS17640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BO992_RS17645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BO992_RS17650	COG0175	sulfate reduction
BO992_RS17670	COG2198	Histidine kinase
BO992_RS17670	COG2205	protein histidine kinase activity
BO992_RS17670	COG0784	Response regulator, receiver
BO992_RS17715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BO992_RS17720	COG3588	fructose-bisphosphate aldolase
BO992_RS17725	COG0469	pyruvate kinase activity
BO992_RS17770	COG0753	catalase activity
BO992_RS17795	COG3039	Transposase
BO992_RS17815	COG2207	Transcriptional regulator
BO992_RS17815	COG1917	Cupin 2, conserved barrel domain protein
BO992_RS17845	COG1506	peptidase
BO992_RS17845	COG0823	Involved in the tonB-independent uptake of proteins
BO992_RS17870	COG3039	Transposase
BO992_RS17875	COG1297	OPT oligopeptide transporter protein
BO992_RS17980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BO992_RS17985	COG3039	Transposase
BO992_RS18000	COG0732	type I restriction modification DNA specificity domain
BO992_RS18005	COG3039	Transposase
BO992_RS18015	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BO992_RS18020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BO992_RS18040	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BO992_RS18245	COG3039	Transposase
BO992_RS18380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BO992_RS18395	COG2197	response regulator
BO992_RS18400	COG4585	Histidine kinase
BO992_RS18420	COG2894	cell division
BO992_RS18425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BO992_RS18435	COG0642	Histidine kinase
BO992_RS18440	COG0745	RESPONSE REGULATOR receiver
BO992_RS18445	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BO992_RS18455	COG2194	sulfuric ester hydrolase activity
BO992_RS18485	COG3551	Protein conserved in bacteria
BO992_RS18550	COG0203	ribosomal protein L17
BO992_RS18560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BO992_RS18565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BO992_RS18575	COG0201	protein transport
BO992_RS18585	COG1841	ribosomal large subunit assembly
BO992_RS18615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BO992_RS18625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BO992_RS18630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BO992_RS18635	COG0255	Belongs to the universal ribosomal protein uL29 family
BO992_RS18640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BO992_RS18650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BO992_RS18665	COG0089	rRNA binding
BO992_RS18670	COG0088	Forms part of the polypeptide exit tunnel
BO992_RS18675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BO992_RS18680	COG0051	transcription antitermination factor activity, RNA binding
BO992_RS18700	COG0049	tRNA binding
BO992_RS18705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BO992_RS18710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BO992_RS18715	COG0085	RNA polymerase activity
BO992_RS18720	COG0222	ribosome binding
BO992_RS18725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BO992_RS18735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BO992_RS18745	COG0250	Participates in transcription elongation, termination and antitermination
BO992_RS18750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BO992_RS18780	COG0012	GTP binding
BO992_RS18785	COG0193	aminoacyl-tRNA hydrolase activity
BO992_RS18795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BO992_RS18810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BO992_RS18825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BO992_RS18835	COG0521	Mo-molybdopterin cofactor biosynthetic process
BO992_RS18855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BO992_RS18860	COG1295	ribonuclease BN
BO992_RS18890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BO992_RS18900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BO992_RS18930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BO992_RS18955	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BO992_RS18970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BO992_RS18970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BO992_RS19020	COG2890	protein-(glutamine-N5) methyltransferase activity
BO992_RS19030	COG3634	alkyl hydroperoxide reductase activity
BO992_RS19035	COG0583	DNA-binding transcription factor activity
BO992_RS19045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BO992_RS19125	COG4783	chaperone-mediated protein folding
BO992_RS19140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BO992_RS19150	COG0438	transferase activity, transferring glycosyl groups
BO992_RS19155	COG0671	phosphoesterase, PA-phosphatase related
BO992_RS19160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BO992_RS19180	COG2833	Protein of unknown function (DUF455)
BO992_RS19200	COG0285	dihydrofolate synthase activity
BO992_RS19210	COG0406	alpha-ribazole phosphatase activity
BO992_RS19245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BO992_RS19250	COG4208	sulfate ABC transporter
BO992_RS19255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BO992_RS19260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BO992_RS19265	COG0156	8-amino-7-oxononanoate synthase activity
BO992_RS19295	COG0604	alcohol dehydrogenase
BO992_RS19300	COG0446	pyridine nucleotide-disulphide oxidoreductase
BO992_RS19300	COG1902	pentaerythritol trinitrate reductase activity
BO992_RS19435	COG3386	PFAM SMP-30 Gluconolaconase
BO992_RS19455	COG1024	Enoyl-CoA hydratase
BO992_RS19465	COG0318	PFAM AMP-dependent synthetase and ligase
BO992_RS19470	COG0583	DNA-binding transcription factor activity
BO992_RS19510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BO992_RS19515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BO992_RS19525	COG2096	Adenosyltransferase
BO992_RS19530	COG0123	including yeast histone deacetylase and acetoin utilization protein
BO992_RS19545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BO992_RS19555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BO992_RS19560	COG2967	ApaG domain
BO992_RS19585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BO992_RS19605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BO992_RS19625	COG0642	Histidine kinase
BO992_RS19640	COG4181	ATPase activity
BO992_RS19650	COG2175	clavaminate synthase activity
BO992_RS19660	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BO992_RS19700	COG0667	Aldo Keto reductase
BO992_RS19710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BO992_RS19715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO992_RS19730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BO992_RS19745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BO992_RS19800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BO992_RS19805	COG2226	methyltransferase
BO992_RS19860	COG3321	synthase
BO992_RS19860	COG0604	alcohol dehydrogenase
BO992_RS19860	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS19875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BO992_RS19890	COG0494	nUDIX hydrolase
BO992_RS19905	COG4942	peptidase
BO992_RS19905	COG1388	LysM domain
BO992_RS19915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BO992_RS19930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BO992_RS19935	COG1181	Belongs to the D-alanine--D-alanine ligase family
BO992_RS19940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BO992_RS19955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BO992_RS19960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BO992_RS19975	COG3116	cell division
BO992_RS19980	COG0275	rRNA processing
BO992_RS20015	COG0792	nuclease activity
BO992_RS20020	COG1988	membrane-bound metal-dependent
BO992_RS20025	COG0277	FAD linked oxidase domain protein
BO992_RS20030	COG0745	RESPONSE REGULATOR receiver
BO992_RS20035	COG2205	protein histidine kinase activity
BO992_RS20045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BO992_RS20050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BO992_RS20075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BO992_RS20080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BO992_RS20085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BO992_RS20105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BO992_RS20105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BO992_RS20125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BO992_RS20145	COG0488	(ABC) transporter
BO992_RS20195	COG2205	protein histidine kinase activity
BO992_RS20235	COG2205	protein histidine kinase activity
BO992_RS20255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BO992_RS20290	COG3039	Transposase
BO992_RS20295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BO992_RS20310	COG3039	Transposase
BO992_RS20365	COG3039	Transposase
BO992_RS20415	COG0726	polysaccharide deacetylase
BO992_RS20415	COG1649	PFAM Uncharacterised BCR, COG1649
BO992_RS20420	COG1215	transferase activity, transferring glycosyl groups
BO992_RS20430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BO992_RS20435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BO992_RS20440	COG1609	Transcriptional regulator
BO992_RS20450	COG2188	Transcriptional regulator
BO992_RS20465	COG3250	beta-galactosidase activity
BO992_RS20520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BO992_RS20525	COG4191	Histidine kinase
BO992_RS20530	COG0784	Response regulator, receiver
BO992_RS20535	COG4251	negative regulation of phosphorylation
BO992_RS20540	COG2823	Periplasmic or secreted lipoprotein
BO992_RS20545	COG0673	inositol 2-dehydrogenase activity
BO992_RS20550	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BO992_RS20585	COG1056	cytidyltransferase-related domain
BO992_RS20585	COG1051	belongs to the nudix hydrolase family
BO992_RS20620	COG2921	Belongs to the UPF0250 family
BO992_RS20635	COG1686	Belongs to the peptidase S11 family
BO992_RS20640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BO992_RS20645	COG2951	lytic endotransglycosylase activity
BO992_RS20665	COG3409	Peptidoglycan-binding domain 1 protein
BO992_RS20665	COG1388	LysM domain
BO992_RS20665	COG5632	N-Acetylmuramoyl-L-alanine amidase
BO992_RS20705	COG0772	Belongs to the SEDS family
BO992_RS20720	COG1792	Involved in formation and maintenance of cell shape
BO992_RS20725	COG1077	Cell shape determining protein MreB Mrl
BO992_RS20730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO992_RS20775	COG2199	diguanylate cyclase activity
BO992_RS20780	COG0308	aminopeptidase N
BO992_RS20810	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BO992_RS20840	COG0436	Aminotransferase
BO992_RS20855	COG1505	serine-type exopeptidase activity
BO992_RS20880	COG0181	hydroxymethylbilane synthase activity
BO992_RS20890	COG3275	phosphorelay sensor kinase activity
BO992_RS20935	COG0659	secondary active sulfate transmembrane transporter activity
BO992_RS20940	COG5297	Belongs to the glycosyl hydrolase family 6
BO992_RS20940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO992_RS21015	COG0598	Magnesium transport protein CorA
BO992_RS21025	COG1113	amino acid transport
BO992_RS21035	COG5297	Belongs to the glycosyl hydrolase family 6
BO992_RS21040	COG4305	rare lipoprotein A
BO992_RS21045	COG0697	spore germination
BO992_RS21105	COG4221	oxidoreductase activity
BO992_RS21135	COG0456	acetyltransferase
BO992_RS21145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BO992_RS21200	COG2111	Na H antiporter
BO992_RS21200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BO992_RS21205	COG1006	Multisubunit Na H antiporter MnhC subunit
BO992_RS21210	COG0651	ATP synthesis coupled electron transport
BO992_RS21220	COG2212	antiporter activity
BO992_RS21225	COG1320	monovalent cation:proton antiporter activity
BO992_RS21235	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BO992_RS21255	COG3104	oligopeptide transport
BO992_RS21260	COG3483	tryptophan 2,3-dioxygenase activity
BO992_RS21270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BO992_RS21305	COG0183	Belongs to the thiolase family
BO992_RS21360	COG3039	Transposase
BO992_RS21395	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BO992_RS21400	COG3023	N-Acetylmuramoyl-L-alanine amidase
BO992_RS21410	COG4948	Mandelate Racemase Muconate Lactonizing
BO992_RS21450	COG0531	amino acid
BO992_RS21485	COG4682	membrane
BO992_RS21490	COG2133	pyrroloquinoline quinone binding
BO992_RS21530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BO992_RS21535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BO992_RS21545	COG1610	YqeY-like protein
BO992_RS21560	COG1295	ribonuclease BN
BO992_RS21565	COG0358	DNA primase activity
BO992_RS21630	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BO992_RS21645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BO992_RS21695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BO992_RS21700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BO992_RS21705	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BO992_RS21715	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BO992_RS21720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BO992_RS21735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BO992_RS21815	COG3039	Transposase
BO992_RS21830	COG3328	transposase activity
BO992_RS21845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BO992_RS21845	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BO992_RS21855	COG1473	amidohydrolase
BO992_RS21860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO992_RS21865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO992_RS21880	COG5383	Protein conserved in bacteria
BO992_RS21925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BO992_RS21930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BO992_RS21945	COG0028	Belongs to the TPP enzyme family
BO992_RS21950	COG4191	Histidine kinase
BO992_RS21975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BO992_RS21990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BO992_RS21995	COG3177	Filamentation induced by cAMP protein fic
BO992_RS22010	COG0596	Alpha beta hydrolase
BO992_RS22015	COG0727	PFAM Uncharacterised protein family (UPF0153)
BO992_RS22020	COG0318	PFAM AMP-dependent synthetase and ligase
BO992_RS22025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BO992_RS22085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BO992_RS22095	COG0129	dihydroxy-acid dehydratase activity
BO992_RS22120	COG3039	Transposase
BO992_RS22130	COG0408	coproporphyrinogen oxidase activity
BO992_RS22230	COG2353	YceI-like domain
BO992_RS22260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BO992_RS22275	COG3386	PFAM SMP-30 Gluconolaconase
BO992_RS22315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BO992_RS22330	COG4771	TonB-dependent receptor
BO992_RS22340	COG0459	protein refolding
BO992_RS22365	COG1252	NADH dehydrogenase
BO992_RS22375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BO992_RS22380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BO992_RS22385	COG3437	response regulator, receiver
BO992_RS22390	COG2177	Part of the ABC transporter FtsEX involved in
BO992_RS22395	COG2884	Cell division ATP-binding protein ftsE
BO992_RS22405	COG3118	belongs to the thioredoxin family
BO992_RS22410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BO992_RS22425	COG0729	surface antigen
BO992_RS22430	COG2911	Protein conserved in bacteria
BO992_RS22465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BO992_RS22480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BO992_RS22540	COG1733	regulation of RNA biosynthetic process
BO992_RS22545	COG0702	epimerase
BO992_RS22575	COG0583	DNA-binding transcription factor activity
BO992_RS22580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BO992_RS22600	COG0745	RESPONSE REGULATOR receiver
BO992_RS22630	COG1902	pentaerythritol trinitrate reductase activity
BO992_RS22635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BO992_RS22645	COG2814	Major facilitator Superfamily
BO992_RS22650	COG0583	DNA-binding transcription factor activity
BO992_RS22670	COG0084	hydrolase, TatD family'
BO992_RS22720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BO992_RS22740	COG2072	flavoprotein involved in K transport
BO992_RS22795	COG4770	biotin carboxylase activity
BO992_RS22800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BO992_RS22805	COG1960	acyl-CoA dehydrogenase activity
BO992_RS22855	COG0523	cobalamin synthesis protein
BO992_RS22865	COG0697	spore germination
BO992_RS22875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BO992_RS22890	COG4771	TonB-dependent receptor
BO992_RS22895	COG0457	Tetratricopeptide repeat
BO992_RS22910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BO992_RS22935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BO992_RS22935	COG0519	Catalyzes the synthesis of GMP from XMP
BO992_RS22945	COG0805	protein transport
BO992_RS22955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BO992_RS22965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BO992_RS23015	COG3661	Belongs to the glycosyl hydrolase 67 family
BO992_RS23025	COG4948	Mandelate Racemase Muconate Lactonizing
BO992_RS23035	COG1472	Belongs to the glycosyl hydrolase 3 family
BO992_RS23040	COG0246	Mannitol dehydrogenase
BO992_RS23065	COG3693	PFAM glycoside hydrolase, family 10
BO992_RS23090	COG2211	Major facilitator Superfamily
BO992_RS23135	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BO992_RS23185	COG1846	Transcriptional regulator
BO992_RS23190	COG1764	response to oxidative stress
BO992_RS23290	COG3549	Plasmid maintenance system killer
BO992_RS23300	COG1074	ATP-dependent DNA helicase activity
BO992_RS23305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BO992_RS23350	COG2032	superoxide dismutase activity
BO992_RS23355	COG2032	superoxide dismutase activity
BO992_RS23360	COG2204	response regulator
BO992_RS23365	COG3852	Histidine kinase
BO992_RS23370	COG0004	ammonium transporteR
BO992_RS23375	COG0347	Belongs to the P(II) protein family
BO992_RS23380	COG0174	glutamine synthetase
BO992_RS23385	COG1968	undecaprenyl-diphosphatase activity
BO992_RS23430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BO992_RS23440	COG2062	phosphohistidine phosphatase, SixA
BO992_RS23445	COG0489	protein tyrosine kinase activity
BO992_RS23465	COG1396	sequence-specific DNA binding
BO992_RS23470	COG3550	peptidyl-serine autophosphorylation
BO992_RS23475	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BO992_RS23480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BO992_RS23495	COG1125	glycine betaine transport
BO992_RS23495	COG0517	IMP dehydrogenase activity
BO992_RS23510	COG1119	ATPase activity
BO992_RS23520	COG1752	Esterase of the alpha-beta hydrolase superfamily
BO992_RS23535	COG3039	Transposase
BO992_RS23560	COG0656	L-ascorbic acid biosynthetic process
BO992_RS23565	COG2130	NADP-dependent
BO992_RS23570	COG0667	Aldo Keto reductase
BO992_RS23580	COG1187	pseudouridine synthase activity
BO992_RS23595	COG1643	Atp-dependent helicase
BO992_RS23600	COG4807	Protein conserved in bacteria
BO992_RS23605	COG4948	Mandelate Racemase Muconate Lactonizing
BO992_RS23615	COG0179	Fumarylacetoacetate (FAA) hydrolase
BO992_RS23620	COG1028	Short-chain dehydrogenase reductase Sdr
BO992_RS23640	COG3507	Belongs to the glycosyl hydrolase 43 family
BO992_RS23680	COG3162	membrane
BO992_RS23685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BO992_RS23700	COG0708	Exodeoxyribonuclease III
BO992_RS23715	COG2091	lysine biosynthetic process via aminoadipic acid
BO992_RS23725	COG3540	Alkaline phosphatase
BO992_RS23755	COG2159	amidohydrolase
BO992_RS23780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BO992_RS23785	COG0583	DNA-binding transcription factor activity
BO992_RS23790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BO992_RS23810	COG0210	DNA helicase
BO992_RS23830	COG0531	amino acid
BO992_RS23840	COG1322	Protein conserved in bacteria
BO992_RS23850	COG0386	Belongs to the glutathione peroxidase family
BO992_RS23905	COG0793	Belongs to the peptidase S41A family
BO992_RS23910	COG4942	peptidase
BO992_RS23920	COG2234	aminopeptidase activity
BO992_RS23970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BO992_RS23975	COG0302	gtp cyclohydrolase
BO992_RS24000	COG0477	Major facilitator Superfamily
BO992_RS24105	COG1929	Belongs to the glycerate kinase type-1 family
BO992_RS24110	COG2271	Major facilitator Superfamily
BO992_RS24125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BO992_RS24135	COG0861	Integral membrane protein TerC family
BO992_RS24145	COG0584	glycerophosphoryl diester phosphodiesterase
BO992_RS24155	COG0671	phosphoesterase, PA-phosphatase related
BO992_RS24165	COG0726	polysaccharide deacetylase