locus-tag	class	description
J4Q40_RS00055	COG3039	Transposase
J4Q40_RS00065	COG3039	Transposase
J4Q40_RS00075	COG3209	COG3209 Rhs family protein
J4Q40_RS00085	COG3039	Transposase
J4Q40_RS00115	COG2198	Histidine kinase
J4Q40_RS00115	COG0784	Response regulator, receiver
J4Q40_RS00115	COG0643	Histidine kinase
J4Q40_RS00170	COG1684	flagellar biosynthetic protein fliR
J4Q40_RS00185	COG3190	flagellar
J4Q40_RS00235	COG1677	Flagellar hook-basal body complex protein FliE
J4Q40_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS00275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4Q40_RS00295	COG2201	protein-glutamate methylesterase activity
J4Q40_RS00325	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J4Q40_RS00330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4Q40_RS00365	COG4787	bacterial-type flagellum-dependent cell motility
J4Q40_RS00375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J4Q40_RS00380	COG1558	bacterial-type flagellum-dependent cell motility
J4Q40_RS00390	COG0784	Response regulator, receiver
J4Q40_RS00390	COG0835	chemotaxis
J4Q40_RS00410	COG5002	protein histidine kinase activity
J4Q40_RS00420	COG4585	Histidine kinase
J4Q40_RS00425	COG5001	Diguanylate cyclase
J4Q40_RS00450	COG0482	sulfurtransferase activity
J4Q40_RS00465	COG0542	response to heat
J4Q40_RS00490	COG0492	ferredoxin-NADP+ reductase activity
J4Q40_RS00495	COG1674	ftsk spoiiie
J4Q40_RS00515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J4Q40_RS00535	COG0038	chloride channel
J4Q40_RS00540	COG0183	Belongs to the thiolase family
J4Q40_RS00545	COG1024	Enoyl-CoA hydratase
J4Q40_RS00545	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4Q40_RS00560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J4Q40_RS00570	COG1426	Protein conserved in bacteria
J4Q40_RS00580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4Q40_RS00590	COG0303	'Molybdopterin
J4Q40_RS00620	COG3039	Transposase
J4Q40_RS00655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4Q40_RS00675	COG0742	ribosomal rna small subunit methyltransferase
J4Q40_RS00680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J4Q40_RS00690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4Q40_RS00695	COG0405	Gamma-glutamyltransferase
J4Q40_RS00770	COG0343	queuine tRNA-ribosyltransferase activity
J4Q40_RS00775	COG1862	Preprotein translocase
J4Q40_RS00780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4Q40_RS00785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4Q40_RS00815	COG3328	transposase activity
J4Q40_RS00830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4Q40_RS00840	COG0704	Plays a role in the regulation of phosphate uptake
J4Q40_RS00855	COG0573	inorganic phosphate transmembrane transporter activity
J4Q40_RS00860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J4Q40_RS00900	COG3039	Transposase
J4Q40_RS00915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4Q40_RS00925	COG1024	Enoyl-CoA hydratase
J4Q40_RS00935	COG0494	nUDIX hydrolase
J4Q40_RS00980	COG0116	Belongs to the methyltransferase superfamily
J4Q40_RS00980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4Q40_RS01005	COG0667	Aldo Keto reductase
J4Q40_RS01015	COG2925	Exonuclease
J4Q40_RS01045	COG0288	reversible hydration of carbon dioxide
J4Q40_RS01075	COG0316	Belongs to the HesB IscA family
J4Q40_RS01080	COG0360	Binds together with S18 to 16S ribosomal RNA
J4Q40_RS01090	COG0359	binds to the 23S rRNA
J4Q40_RS01100	COG3115	cell septum assembly
J4Q40_RS01115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J4Q40_RS01130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J4Q40_RS01155	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J4Q40_RS01165	COG2986	histidine ammonia-lyase
J4Q40_RS01170	COG1228	amidohydrolase
J4Q40_RS01210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J4Q40_RS01220	COG0077	Prephenate dehydratase
J4Q40_RS01220	COG1605	Chorismate mutase
J4Q40_RS01225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J4Q40_RS01255	COG4566	intracellular signal transduction
J4Q40_RS01300	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4Q40_RS01305	COG1469	GTP cyclohydrolase I activity
J4Q40_RS01315	COG0617	tRNA 3'-terminal CCA addition
J4Q40_RS01330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J4Q40_RS01360	COG1472	Belongs to the glycosyl hydrolase 3 family
J4Q40_RS01375	COG3706	GGDEF domain
J4Q40_RS01375	COG4251	negative regulation of phosphorylation
J4Q40_RS01375	COG5001	Diguanylate cyclase
J4Q40_RS01375	COG2203	Gaf domain
J4Q40_RS01460	COG0386	Belongs to the glutathione peroxidase family
J4Q40_RS01540	COG0784	Response regulator, receiver
J4Q40_RS01540	COG2205	protein histidine kinase activity
J4Q40_RS01540	COG5002	protein histidine kinase activity
J4Q40_RS01570	COG0800	Aldolase
J4Q40_RS01575	COG0129	dihydroxy-acid dehydratase activity
J4Q40_RS01580	COG0363	glucosamine-6-phosphate deaminase activity
J4Q40_RS01590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J4Q40_RS01605	COG0354	folic acid binding
J4Q40_RS01620	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J4Q40_RS01635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J4Q40_RS01650	COG4591	ABC-type transport system involved in lipoprotein release permease component
J4Q40_RS01675	COG0811	peptide transport
J4Q40_RS01690	COG1663	tetraacyldisaccharide 4'-kinase activity
J4Q40_RS01700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4Q40_RS01710	COG0322	excinuclease ABC activity
J4Q40_RS01745	COG3328	transposase activity
J4Q40_RS01765	COG3039	Transposase
J4Q40_RS01785	COG2801	Transposase and inactivated derivatives
J4Q40_RS01795	COG2201	protein-glutamate methylesterase activity
J4Q40_RS01810	COG3293	Transposase
J4Q40_RS02000	COG0653	protein targeting
J4Q40_RS02040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J4Q40_RS02040	COG0140	phosphoribosyl-ATP diphosphatase activity
J4Q40_RS02050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J4Q40_RS02060	COG0131	Imidazoleglycerol-phosphate dehydratase
J4Q40_RS02060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J4Q40_RS02075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J4Q40_RS02095	COG0124	histidyl-tRNA synthetase
J4Q40_RS02110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J4Q40_RS02145	COG1012	belongs to the aldehyde dehydrogenase family
J4Q40_RS02165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J4Q40_RS02170	COG0697	spore germination
J4Q40_RS02175	COG1794	racemase activity, acting on amino acids and derivatives
J4Q40_RS02200	COG0671	phosphoesterase, PA-phosphatase related
J4Q40_RS02215	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J4Q40_RS02230	COG2183	response to ionizing radiation
J4Q40_RS02240	COG0723	plastoquinol--plastocyanin reductase activity
J4Q40_RS02240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4Q40_RS02255	COG3243	poly(R)-hydroxyalkanoic acid synthase
J4Q40_RS02265	COG1183	phosphatidylcholine synthase activity
J4Q40_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS02315	COG0668	transmembrane transport
J4Q40_RS02335	COG1914	H( )-stimulated, divalent metal cation uptake system
J4Q40_RS02380	COG0583	DNA-binding transcription factor activity
J4Q40_RS02385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4Q40_RS02390	COG3002	Belongs to the UPF0753 family
J4Q40_RS02405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J4Q40_RS02425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J4Q40_RS02435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4Q40_RS02440	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J4Q40_RS02450	COG0776	regulation of translation
J4Q40_RS02455	COG0539	negative regulation of cytoplasmic translation
J4Q40_RS02460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J4Q40_RS02475	COG2957	Belongs to the agmatine deiminase family
J4Q40_RS02485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4Q40_RS02510	COG0395	ABC-type sugar transport system, permease component
J4Q40_RS02515	COG1175	transmembrane transport
J4Q40_RS02545	COG2350	Protein conserved in bacteria
J4Q40_RS02550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J4Q40_RS02555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J4Q40_RS02560	COG1187	pseudouridine synthase activity
J4Q40_RS02585	COG0436	Aminotransferase
J4Q40_RS02650	COG0277	FAD linked oxidase domain protein
J4Q40_RS02655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4Q40_RS02665	COG0531	amino acid
J4Q40_RS02670	COG0531	amino acid
J4Q40_RS02680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J4Q40_RS02710	COG2201	protein-glutamate methylesterase activity
J4Q40_RS02755	COG0583	DNA-binding transcription factor activity
J4Q40_RS02765	COG3039	Transposase
J4Q40_RS02820	COG3039	Transposase
J4Q40_RS02870	COG3039	Transposase
J4Q40_RS02875	COG3039	Transposase
J4Q40_RS02890	COG1278	Cold shock
J4Q40_RS02900	COG3328	transposase activity
J4Q40_RS02920	COG3039	Transposase
J4Q40_RS02930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4Q40_RS02950	COG0557	exoribonuclease II activity
J4Q40_RS02975	COG1960	acyl-CoA dehydrogenase activity
J4Q40_RS02980	COG2226	methyltransferase
J4Q40_RS02985	COG0646	methionine synthase
J4Q40_RS02985	COG1410	methionine synthase
J4Q40_RS02990	COG0646	methionine synthase
J4Q40_RS02990	COG1410	methionine synthase
J4Q40_RS03000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4Q40_RS03010	COG1609	Transcriptional regulator
J4Q40_RS03025	COG2900	Belongs to the SlyX family
J4Q40_RS03040	COG0386	Belongs to the glutathione peroxidase family
J4Q40_RS03050	COG1725	Transcriptional regulator
J4Q40_RS03055	COG1131	(ABC) transporter
J4Q40_RS03140	COG2850	peptidyl-arginine hydroxylation
J4Q40_RS03175	COG1132	(ABC) transporter
J4Q40_RS03190	COG0583	DNA-binding transcription factor activity
J4Q40_RS03205	COG0287	Prephenate dehydrogenase
J4Q40_RS03205	COG1605	Chorismate mutase
J4Q40_RS03210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J4Q40_RS03215	COG0484	heat shock protein binding
J4Q40_RS03220	COG0443	Heat shock 70 kDa protein
J4Q40_RS03225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J4Q40_RS03235	COG0497	DNA recombination
J4Q40_RS03245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4Q40_RS03250	COG2914	Belongs to the UPF0125 (RnfH) family
J4Q40_RS03275	COG1960	acyl-CoA dehydrogenase activity
J4Q40_RS03285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J4Q40_RS03330	COG2814	Major facilitator Superfamily
J4Q40_RS03335	COG1566	PFAM secretion protein HlyD family protein
J4Q40_RS03370	COG4774	siderophore transport
J4Q40_RS03380	COG0367	asparagine synthase
J4Q40_RS03395	COG1393	Belongs to the ArsC family
J4Q40_RS03455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J4Q40_RS03470	COG0233	cytoplasmic translational termination
J4Q40_RS03480	COG0575	Belongs to the CDS family
J4Q40_RS03490	COG0750	zinc metalloprotease
J4Q40_RS03505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4Q40_RS03510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4Q40_RS03530	COG0825	malonyl-CoA metabolic process
J4Q40_RS03540	COG4771	TonB-dependent receptor
J4Q40_RS03545	COG1131	(ABC) transporter
J4Q40_RS03565	COG1981	membrane
J4Q40_RS03610	COG2895	sulfate adenylyltransferase (ATP) activity
J4Q40_RS03610	COG0529	Catalyzes the synthesis of activated sulfate
J4Q40_RS03645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J4Q40_RS03660	COG2040	homocysteine
J4Q40_RS03665	COG0833	amino acid
J4Q40_RS03685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4Q40_RS03685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4Q40_RS03695	COG2878	Part of a membrane complex involved in electron transport
J4Q40_RS03710	COG1595	DNA-templated transcription, initiation
J4Q40_RS03735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J4Q40_RS03750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J4Q40_RS03755	COG0251	oxidation-reduction process
J4Q40_RS03765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J4Q40_RS03765	COG0392	lysyltransferase activity
J4Q40_RS03810	COG2814	Major facilitator Superfamily
J4Q40_RS03815	COG1902	pentaerythritol trinitrate reductase activity
J4Q40_RS03825	COG2824	Alkylphosphonate utilization operon protein PhnA
J4Q40_RS03840	COG1047	Peptidyl-prolyl cis-trans
J4Q40_RS03875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J4Q40_RS03890	COG1451	nucleotide metabolic process
J4Q40_RS03910	COG0183	Belongs to the thiolase family
J4Q40_RS03940	COG1793	dna ligase
J4Q40_RS03940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J4Q40_RS03950	COG1793	dna ligase
J4Q40_RS03955	COG1201	RNA secondary structure unwinding
J4Q40_RS03975	COG1278	Cold shock
J4Q40_RS03980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J4Q40_RS03985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J4Q40_RS03995	COG3046	protein related to deoxyribodipyrimidine photolyase
J4Q40_RS04000	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J4Q40_RS04005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J4Q40_RS04020	COG2954	triphosphatase activity
J4Q40_RS04035	COG1381	Involved in DNA repair and RecF pathway recombination
J4Q40_RS04065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4Q40_RS04080	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4Q40_RS04080	COG1024	Enoyl-CoA hydratase
J4Q40_RS04100	COG1024	Enoyl-CoA hydratase
J4Q40_RS04105	COG1960	acyl-CoA dehydrogenase activity
J4Q40_RS04125	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J4Q40_RS04175	COG2353	YceI-like domain
J4Q40_RS04185	COG2353	YceI-like domain
J4Q40_RS04200	COG1760	l-serine dehydratase
J4Q40_RS04210	COG0626	cystathionine gamma-synthase activity
J4Q40_RS04215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4Q40_RS04220	COG0739	heme binding
J4Q40_RS04230	COG1272	protein, Hemolysin III
J4Q40_RS04250	COG0463	Glycosyl transferase, family 2
J4Q40_RS04260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J4Q40_RS04270	COG4771	TonB-dependent receptor
J4Q40_RS04275	COG1309	transcriptional regulator
J4Q40_RS04285	COG1960	acyl-CoA dehydrogenase activity
J4Q40_RS04320	COG0509	glycine decarboxylation via glycine cleavage system
J4Q40_RS04335	COG0330	HflC and HflK could
J4Q40_RS04350	COG3956	TIGRFAM MazG family protein
J4Q40_RS04360	COG0494	nUDIX hydrolase
J4Q40_RS04370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J4Q40_RS04375	COG0837	glucose binding
J4Q40_RS04390	COG1388	LysM domain
J4Q40_RS04390	COG3858	chitin binding
J4Q40_RS04400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4Q40_RS04410	COG1472	Belongs to the glycosyl hydrolase 3 family
J4Q40_RS04485	COG3537	Alpha-1,2-mannosidase
J4Q40_RS04535	COG3142	Participates in the control of copper homeostasis
J4Q40_RS04540	COG1446	asparaginase
J4Q40_RS04575	COG2198	Histidine kinase
J4Q40_RS04575	COG0784	Response regulator, receiver
J4Q40_RS04575	COG0643	Histidine kinase
J4Q40_RS04580	COG0840	transmembrane signaling receptor activity
J4Q40_RS04585	COG0835	chemotaxis
J4Q40_RS04600	COG0189	ligase activity
J4Q40_RS04610	COG1397	ADP-ribosylglycohydrolase
J4Q40_RS04620	COG1199	ATP-dependent helicase activity
J4Q40_RS04630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4Q40_RS04635	COG1215	transferase activity, transferring glycosyl groups
J4Q40_RS04645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4Q40_RS04695	COG1643	Atp-dependent helicase
J4Q40_RS04700	COG0783	Belongs to the Dps family
J4Q40_RS04705	COG0514	ATP-dependent DNA helicase (RecQ)
J4Q40_RS04775	COG4695	Portal protein
J4Q40_RS04820	COG3179	chitinase
J4Q40_RS04995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J4Q40_RS05045	COG1187	pseudouridine synthase activity
J4Q40_RS05050	COG0602	queuosine metabolic process
J4Q40_RS05060	COG2885	chlorophyll binding
J4Q40_RS05075	COG0848	biopolymer transport protein
J4Q40_RS05085	COG0824	Thioesterase
J4Q40_RS05090	COG2255	four-way junction helicase activity
J4Q40_RS05100	COG0632	four-way junction helicase activity
J4Q40_RS05205	COG3209	COG3209 Rhs family protein
J4Q40_RS05205	COG3209	COG3209 Rhs family protein
J4Q40_RS05225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J4Q40_RS05230	COG1845	cytochrome c oxidase, subunit III
J4Q40_RS05235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J4Q40_RS05250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J4Q40_RS05255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J4Q40_RS05265	COG0196	riboflavin kinase activity
J4Q40_RS05270	COG0728	peptidoglycan biosynthetic process
J4Q40_RS05275	COG0268	Binds directly to 16S ribosomal RNA
J4Q40_RS05280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J4Q40_RS05285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J4Q40_RS05295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4Q40_RS05300	COG0824	Thioesterase
J4Q40_RS05315	COG1946	Acyl-CoA thioesterase
J4Q40_RS05325	COG1595	DNA-templated transcription, initiation
J4Q40_RS05345	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J4Q40_RS05385	COG1877	trehalose-phosphatase activity
J4Q40_RS05390	COG3387	PFAM Glycoside hydrolase 15-related
J4Q40_RS05415	COG0564	pseudouridine synthase activity
J4Q40_RS05420	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4Q40_RS05425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J4Q40_RS05425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4Q40_RS05435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J4Q40_RS05440	COG0045	succinate-CoA ligase (ADP-forming) activity
J4Q40_RS05480	COG2194	sulfuric ester hydrolase activity
J4Q40_RS05485	COG4969	Belongs to the N-Me-Phe pilin family
J4Q40_RS05495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J4Q40_RS05530	COG3039	Transposase
J4Q40_RS05555	COG3039	Transposase
J4Q40_RS05585	COG1132	(ABC) transporter
J4Q40_RS05615	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS05620	COG5000	phosphorelay sensor kinase activity
J4Q40_RS05620	COG5002	protein histidine kinase activity
J4Q40_RS05625	COG0475	glutathione-regulated potassium exporter activity
J4Q40_RS05635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J4Q40_RS05655	COG1187	pseudouridine synthase activity
J4Q40_RS05660	COG5001	Diguanylate cyclase
J4Q40_RS05660	COG5002	protein histidine kinase activity
J4Q40_RS05775	COG0415	Belongs to the DNA photolyase family
J4Q40_RS05780	COG0305	Participates in initiation and elongation during chromosome replication
J4Q40_RS05790	COG0367	asparagine synthase
J4Q40_RS05805	COG1960	acyl-CoA dehydrogenase activity
J4Q40_RS05820	COG0084	hydrolase, TatD family'
J4Q40_RS05825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J4Q40_RS05885	COG0735	belongs to the Fur family
J4Q40_RS05890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4Q40_RS05925	COG3039	Transposase
J4Q40_RS05950	COG3039	Transposase
J4Q40_RS05975	COG2205	protein histidine kinase activity
J4Q40_RS05985	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J4Q40_RS05995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4Q40_RS06010	COG0643	Histidine kinase
J4Q40_RS06010	COG2198	Histidine kinase
J4Q40_RS06015	COG0840	transmembrane signaling receptor activity
J4Q40_RS06020	COG0835	chemotaxis
J4Q40_RS06025	COG2202	Pas domain
J4Q40_RS06025	COG2199	diguanylate cyclase activity
J4Q40_RS06025	COG2200	EAL domain
J4Q40_RS06030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J4Q40_RS06045	COG3590	peptidase
J4Q40_RS06065	COG1515	deoxyribonuclease V activity
J4Q40_RS06070	COG1741	Belongs to the pirin family
J4Q40_RS06190	COG1741	Belongs to the pirin family
J4Q40_RS06195	COG1966	Carbon starvation protein
J4Q40_RS06200	COG2879	small protein
J4Q40_RS06235	COG3706	GGDEF domain
J4Q40_RS06235	COG4251	negative regulation of phosphorylation
J4Q40_RS06235	COG5001	Diguanylate cyclase
J4Q40_RS06235	COG2203	Gaf domain
J4Q40_RS06240	COG0629	single-stranded DNA binding
J4Q40_RS06245	COG0142	geranyltranstransferase activity
J4Q40_RS06270	COG0527	aspartate kinase activity
J4Q40_RS06280	COG0384	phenazine biosynthesis protein PhzF
J4Q40_RS06290	COG1764	response to oxidative stress
J4Q40_RS06305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J4Q40_RS06310	COG1678	Uncharacterized ACR, COG1678
J4Q40_RS06320	COG0519	Catalyzes the synthesis of GMP from XMP
J4Q40_RS06350	COG3039	Transposase
J4Q40_RS06355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J4Q40_RS06395	COG0693	protein deglycase activity
J4Q40_RS06415	COG1959	2 iron, 2 sulfur cluster binding
J4Q40_RS06420	COG0719	Fe-S assembly protein
J4Q40_RS06425	COG0396	ATPase activity
J4Q40_RS06430	COG0719	Fe-S assembly protein
J4Q40_RS06435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4Q40_RS06445	COG2146	nitrite reductase [NAD(P)H] activity
J4Q40_RS06480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J4Q40_RS06495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J4Q40_RS06505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
J4Q40_RS06510	COG0174	glutamine synthetase
J4Q40_RS06515	COG3328	transposase activity
J4Q40_RS06540	COG0326	Molecular chaperone. Has ATPase activity
J4Q40_RS06545	COG2207	Transcriptional regulator
J4Q40_RS06575	COG0657	acetylesterase activity
J4Q40_RS06575	COG2755	lipolytic protein G-D-S-L family
J4Q40_RS06600	COG0488	(ABC) transporter
J4Q40_RS06635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J4Q40_RS06635	COG4651	solute:proton antiporter activity
J4Q40_RS06650	COG4772	TonB-dependent receptor
J4Q40_RS06660	COG4264	IucA IucC family
J4Q40_RS06665	COG2814	Major facilitator Superfamily
J4Q40_RS06675	COG0019	diaminopimelate decarboxylase activity
J4Q40_RS06735	COG4206	TonB-dependent receptor
J4Q40_RS06770	COG0542	response to heat
J4Q40_RS06805	COG0534	Mate efflux family protein
J4Q40_RS06820	COG0336	Belongs to the RNA methyltransferase TrmD family
J4Q40_RS06825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J4Q40_RS06830	COG0228	four-way junction DNA binding
J4Q40_RS06850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4Q40_RS06860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4Q40_RS06905	COG1555	photosystem II stabilization
J4Q40_RS06910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4Q40_RS06925	COG3178	'Phosphotransferase
J4Q40_RS06930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J4Q40_RS06940	COG0628	permease
J4Q40_RS06950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J4Q40_RS06965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4Q40_RS06985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4Q40_RS06990	COG0271	Belongs to the BolA IbaG family
J4Q40_RS07000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J4Q40_RS07010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J4Q40_RS07015	COG1137	ATPase activity
J4Q40_RS07030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4Q40_RS07035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J4Q40_RS07040	COG1660	Displays ATPase and GTPase activities
J4Q40_RS07050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4Q40_RS07055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4Q40_RS07060	COG2239	Acts as a magnesium transporter
J4Q40_RS07070	COG1294	oxidase, subunit
J4Q40_RS07075	COG1271	oxidase subunit
J4Q40_RS07090	COG1113	amino acid transport
J4Q40_RS07105	COG2197	response regulator
J4Q40_RS07110	COG0531	amino acid
J4Q40_RS07165	COG0754	glutathionylspermidine amidase activity
J4Q40_RS07190	COG1842	Phage shock protein A
J4Q40_RS07205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J4Q40_RS07210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J4Q40_RS07220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J4Q40_RS07250	COG2201	protein-glutamate methylesterase activity
J4Q40_RS07355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4Q40_RS07360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4Q40_RS07400	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS07405	COG2205	protein histidine kinase activity
J4Q40_RS07425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4Q40_RS07455	COG3453	Protein conserved in bacteria
J4Q40_RS07455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4Q40_RS07460	COG0725	ABC transporter, periplasmic molybdate-binding protein
J4Q40_RS07465	COG4149	molybdate abc transporter
J4Q40_RS07470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J4Q40_RS07490	COG0642	Histidine kinase
J4Q40_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS07515	COG1022	Amp-dependent synthetase and ligase
J4Q40_RS07540	COG1376	ErfK ybiS ycfS ynhG family protein
J4Q40_RS07545	COG0739	heme binding
J4Q40_RS07555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J4Q40_RS07560	COG1301	dicarboxylic acid transport
J4Q40_RS07580	COG2304	oxidoreductase activity
J4Q40_RS07600	COG0714	Associated with various cellular activities
J4Q40_RS07650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J4Q40_RS07680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4Q40_RS07690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4Q40_RS07715	COG1561	YicC-like family, N-terminal region
J4Q40_RS07720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J4Q40_RS07735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4Q40_RS07775	COG0006	proline dipeptidase activity
J4Q40_RS07800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J4Q40_RS07820	COG2912	Transglutaminase-like superfamily
J4Q40_RS07825	COG1773	rubredoxin
J4Q40_RS07830	COG0352	thiamine-phosphate diphosphorylase activity
J4Q40_RS07860	COG0280	phosphate acetyltransferase
J4Q40_RS07860	COG0281	malic enzyme
J4Q40_RS07880	COG4191	Histidine kinase
J4Q40_RS07895	COG0583	DNA-binding transcription factor activity
J4Q40_RS07910	COG2197	response regulator
J4Q40_RS07920	COG0642	Histidine kinase
J4Q40_RS07935	COG2851	Citrate transporter
J4Q40_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS07945	COG1609	Transcriptional regulator
J4Q40_RS07955	COG2211	Major facilitator Superfamily
J4Q40_RS08005	COG0726	polysaccharide deacetylase
J4Q40_RS08010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J4Q40_RS08035	COG3039	Transposase
J4Q40_RS08080	COG0242	peptide deformylase activity
J4Q40_RS08100	COG0714	Associated with various cellular activities
J4Q40_RS08120	COG0537	adenosine 5'-monophosphoramidase activity
J4Q40_RS08150	COG0314	molybdopterin synthase activity
J4Q40_RS08155	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J4Q40_RS08160	COG0315	cyclic pyranopterin monophosphate synthase activity
J4Q40_RS08170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J4Q40_RS08175	COG1234	tRNA 3'-trailer cleavage
J4Q40_RS08180	COG3642	lipopolysaccharide core region biosynthetic process
J4Q40_RS08185	COG0859	PFAM glycosyl transferase family 9
J4Q40_RS08195	COG0582	viral genome integration into host DNA
J4Q40_RS08265	COG0631	protein serine/threonine phosphatase activity
J4Q40_RS08275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4Q40_RS08300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4Q40_RS08340	COG0544	peptidyl-prolyl cis-trans isomerase activity
J4Q40_RS08390	COG0473	3-isopropylmalate dehydrogenase activity
J4Q40_RS08415	COG0584	glycerophosphoryl diester phosphodiesterase
J4Q40_RS08435	COG3039	Transposase
J4Q40_RS08565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J4Q40_RS08585	COG1217	gtp-binding protein TYPA
J4Q40_RS08590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4Q40_RS08600	COG0625	glutathione transferase activity
J4Q40_RS08615	COG3781	membrane
J4Q40_RS08625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4Q40_RS08655	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J4Q40_RS08665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J4Q40_RS08675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J4Q40_RS08700	COG3710	Transcriptional regulator
J4Q40_RS08705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J4Q40_RS08715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J4Q40_RS08750	COG0066	3-isopropylmalate dehydratase activity
J4Q40_RS08755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J4Q40_RS08780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J4Q40_RS08785	COG1538	Outer membrane efflux protein
J4Q40_RS08790	COG1519	Transferase
J4Q40_RS08795	COG1560	Kdo2-lipid A biosynthetic process
J4Q40_RS08815	COG3039	Transposase
J4Q40_RS08850	COG0308	aminopeptidase N
J4Q40_RS08865	COG0330	HflC and HflK could
J4Q40_RS08870	COG0330	HflC and HflK could
J4Q40_RS08890	COG0678	peroxiredoxin activity
J4Q40_RS08900	COG2826	transposase and inactivated derivatives, IS30 family
J4Q40_RS08945	COG3039	Transposase
J4Q40_RS08975	COG3829	transcription factor binding
J4Q40_RS09010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J4Q40_RS09015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4Q40_RS09025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4Q40_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS09055	COG1399	metal-binding, possibly nucleic acid-binding protein
J4Q40_RS09095	COG1518	maintenance of DNA repeat elements
J4Q40_RS09100	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J4Q40_RS09150	COG2188	Transcriptional regulator
J4Q40_RS09165	COG1450	Type ii and iii secretion system protein
J4Q40_RS09180	COG3166	PFAM Fimbrial assembly family protein
J4Q40_RS09185	COG3156	type II secretion system protein K
J4Q40_RS09190	COG4795	General secretion pathway protein
J4Q40_RS09195	COG2165	general secretion pathway protein
J4Q40_RS09200	COG4970	Tfp pilus assembly protein FimT
J4Q40_RS09205	COG2165	general secretion pathway protein
J4Q40_RS09210	COG1459	type II secretion system
J4Q40_RS09220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4Q40_RS09225	COG1404	Belongs to the peptidase S8 family
J4Q40_RS09250	COG5295	Hep Hag repeat protein
J4Q40_RS09255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4Q40_RS09255	COG0047	phosphoribosylformylglycinamidine synthase activity
J4Q40_RS09260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J4Q40_RS09265	COG4974	Belongs to the 'phage' integrase family
J4Q40_RS09275	COG0795	lipopolysaccharide-transporting ATPase activity
J4Q40_RS09285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J4Q40_RS09300	COG0525	valine-tRNA ligase activity
J4Q40_RS09355	COG3039	Transposase
J4Q40_RS09380	COG1183	phosphatidylcholine synthase activity
J4Q40_RS09390	COG0442	prolyl-tRNA aminoacylation
J4Q40_RS09405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J4Q40_RS09410	COG1127	ABC transporter
J4Q40_RS09415	COG3218	ABC-type transport auxiliary lipoprotein component
J4Q40_RS09415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J4Q40_RS09450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4Q40_RS09455	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J4Q40_RS09455	COG0662	Cupin 2, conserved barrel domain protein
J4Q40_RS09480	COG2086	electron transfer activity
J4Q40_RS09505	COG3328	transposase activity
J4Q40_RS09545	COG0626	cystathionine gamma-synthase activity
J4Q40_RS09585	COG0513	Belongs to the DEAD box helicase family
J4Q40_RS09590	COG0720	synthase
J4Q40_RS09600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J4Q40_RS09605	COG1956	GAF domain-containing protein
J4Q40_RS09640	COG0339	signal peptide processing
J4Q40_RS09695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J4Q40_RS09700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4Q40_RS09750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J4Q40_RS09755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J4Q40_RS09760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J4Q40_RS09765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J4Q40_RS09775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J4Q40_RS09785	COG0356	it plays a direct role in the translocation of protons across the membrane
J4Q40_RS09805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4Q40_RS09815	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4Q40_RS09845	COG2011	ABC-type metal ion transport system permease component
J4Q40_RS09855	COG0697	spore germination
J4Q40_RS09890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4Q40_RS09895	COG1187	pseudouridine synthase activity
J4Q40_RS09900	COG2813	Specifically methylates the guanine in position
J4Q40_RS09930	COG2205	protein histidine kinase activity
J4Q40_RS09930	COG2202	Pas domain
J4Q40_RS09955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4Q40_RS10005	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS10020	COG1404	Belongs to the peptidase S8 family
J4Q40_RS10040	COG0842	Transport permease protein
J4Q40_RS10045	COG1131	(ABC) transporter
J4Q40_RS10050	COG0025	NhaP-type Na H and K H
J4Q40_RS10065	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J4Q40_RS10075	COG1573	uracil-dna glycosylase
J4Q40_RS10085	COG3384	dioxygenase
J4Q40_RS10100	COG0667	Aldo Keto reductase
J4Q40_RS10115	COG3590	peptidase
J4Q40_RS10135	COG0531	amino acid
J4Q40_RS10150	COG2972	Histidine kinase
J4Q40_RS10175	COG2204	response regulator
J4Q40_RS10185	COG1271	oxidase subunit
J4Q40_RS10190	COG1294	oxidase, subunit
J4Q40_RS10410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4Q40_RS10420	COG1560	Kdo2-lipid A biosynthetic process
J4Q40_RS10470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J4Q40_RS10470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4Q40_RS10475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J4Q40_RS10480	COG0242	peptide deformylase activity
J4Q40_RS10485	COG1652	LysM domain
J4Q40_RS10490	COG0758	DNA mediated transformation
J4Q40_RS10495	COG2922	Belongs to the Smg family
J4Q40_RS10510	COG1754	DNA topoisomerase type I activity
J4Q40_RS10510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4Q40_RS10515	COG0009	L-threonylcarbamoyladenylate synthase
J4Q40_RS10530	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS10540	COG0616	signal peptide processing
J4Q40_RS10545	COG0534	Mate efflux family protein
J4Q40_RS10565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4Q40_RS10600	COG1324	tolerance protein
J4Q40_RS10610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J4Q40_RS10615	COG0511	ligase activity, forming carbon-carbon bonds
J4Q40_RS10625	COG0439	Biotin carboxylase
J4Q40_RS10670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J4Q40_RS10690	COG2267	carboxylic ester hydrolase activity
J4Q40_RS10695	COG2267	carboxylic ester hydrolase activity
J4Q40_RS10710	COG0419	ATPase involved in DNA repair
J4Q40_RS10720	COG0151	Belongs to the GarS family
J4Q40_RS10725	COG0577	efflux transmembrane transporter activity
J4Q40_RS10725	COG1136	(ABC) transporter
J4Q40_RS10735	COG1289	transmembrane transporter activity
J4Q40_RS10750	COG2814	Major facilitator Superfamily
J4Q40_RS10765	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J4Q40_RS10805	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS10850	COG0739	heme binding
J4Q40_RS10865	COG2211	Major facilitator Superfamily
J4Q40_RS10870	COG0708	Exodeoxyribonuclease III
J4Q40_RS10885	COG1192	Involved in chromosome partitioning
J4Q40_RS10890	COG1475	DNA binding
J4Q40_RS10905	COG0463	Glycosyl transferase, family 2
J4Q40_RS10930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4Q40_RS10935	COG2003	Belongs to the UPF0758 family
J4Q40_RS10940	COG0018	arginyl-trna synthetase
J4Q40_RS10955	COG4221	oxidoreductase activity
J4Q40_RS10980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J4Q40_RS10985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4Q40_RS10990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J4Q40_RS11000	COG3485	protocatechuate 3,4-dioxygenase
J4Q40_RS11005	COG3485	protocatechuate 3,4-dioxygenase
J4Q40_RS11040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4Q40_RS11045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4Q40_RS11055	COG0045	succinate-CoA ligase (ADP-forming) activity
J4Q40_RS11055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4Q40_RS11055	COG1042	CoA-binding domain protein
J4Q40_RS11065	COG2239	Acts as a magnesium transporter
J4Q40_RS11080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J4Q40_RS11100	COG3100	YcgL domain-containing protein
J4Q40_RS11105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4Q40_RS11115	COG0463	Glycosyl transferase, family 2
J4Q40_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS11140	COG0156	8-amino-7-oxononanoate synthase activity
J4Q40_RS11145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J4Q40_RS11150	COG1040	competence protein
J4Q40_RS11155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J4Q40_RS11165	COG0628	permease
J4Q40_RS11175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J4Q40_RS11185	COG1595	DNA-templated transcription, initiation
J4Q40_RS11190	COG0753	catalase activity
J4Q40_RS11235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4Q40_RS11240	COG0180	Tryptophanyl-tRNA synthetase
J4Q40_RS11245	COG3237	CsbD-like
J4Q40_RS11280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J4Q40_RS11295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J4Q40_RS11300	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J4Q40_RS11300	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J4Q40_RS11340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4Q40_RS11365	COG1566	PFAM secretion protein HlyD family protein
J4Q40_RS11380	COG1199	ATP-dependent helicase activity
J4Q40_RS11420	COG0583	DNA-binding transcription factor activity
J4Q40_RS11465	COG0625	glutathione transferase activity
J4Q40_RS11500	COG4555	ABC transporter
J4Q40_RS11510	COG1476	TRANSCRIPTIONal
J4Q40_RS11535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4Q40_RS11540	COG1131	(ABC) transporter
J4Q40_RS11545	COG0842	Transport permease protein
J4Q40_RS11555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J4Q40_RS11640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J4Q40_RS11650	COG0564	pseudouridine synthase activity
J4Q40_RS11680	COG0339	signal peptide processing
J4Q40_RS11710	COG3254	rhamnose metabolic process
J4Q40_RS11715	COG0738	Major facilitator superfamily
J4Q40_RS11720	COG1414	Transcriptional regulator
J4Q40_RS11730	COG2205	protein histidine kinase activity
J4Q40_RS11740	COG3459	Glycosyltransferase 36 associated
J4Q40_RS11745	COG2211	Major facilitator Superfamily
J4Q40_RS11750	COG3265	gluconokinase activity
J4Q40_RS11760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4Q40_RS11835	COG1127	ABC transporter
J4Q40_RS11840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J4Q40_RS11845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J4Q40_RS11860	COG2853	Lipoprotein
J4Q40_RS11880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J4Q40_RS11945	COG0676	glucose-6-phosphate 1-epimerase activity
J4Q40_RS11950	COG3039	Transposase
J4Q40_RS11975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J4Q40_RS11985	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J4Q40_RS11995	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J4Q40_RS12000	COG1064	alcohol dehydrogenase
J4Q40_RS12045	COG1522	sequence-specific DNA binding
J4Q40_RS12050	COG3186	Phenylalanine-4-hydroxylase
J4Q40_RS12090	COG2937	Belongs to the GPAT DAPAT family
J4Q40_RS12125	COG0284	orotidine-5'-phosphate decarboxylase activity
J4Q40_RS12130	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J4Q40_RS12135	COG3132	Protein of unknown function, DUF480
J4Q40_RS12150	COG0210	DNA helicase
J4Q40_RS12165	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J4Q40_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS12215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J4Q40_RS12275	COG1166	arginine decarboxylase activity
J4Q40_RS12280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J4Q40_RS12320	COG0606	chelatase, subunit chli
J4Q40_RS12365	COG0366	Alpha amylase catalytic
J4Q40_RS12370	COG0366	Alpha amylase catalytic
J4Q40_RS12400	COG1609	Transcriptional regulator
J4Q40_RS12450	COG0493	'glutamate synthase
J4Q40_RS12455	COG0069	glutamate synthase activity
J4Q40_RS12455	COG0070	glutamate synthase
J4Q40_RS12455	COG0067	glutamate synthase
J4Q40_RS12515	COG1111	helicase
J4Q40_RS12515	COG1205	dead DEAH box helicase
J4Q40_RS12520	COG1272	protein, Hemolysin III
J4Q40_RS12560	COG1136	(ABC) transporter
J4Q40_RS12620	COG2826	transposase and inactivated derivatives, IS30 family
J4Q40_RS12645	COG3039	Transposase
J4Q40_RS12655	COG1090	epimerase
J4Q40_RS12665	COG0642	Histidine kinase
J4Q40_RS12675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4Q40_RS12785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J4Q40_RS12860	COG1511	domain protein
J4Q40_RS12860	COG3264	Mechanosensitive ion channel
J4Q40_RS12875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J4Q40_RS12880	COG2354	Protein conserved in bacteria
J4Q40_RS12885	COG1649	PFAM Uncharacterised BCR, COG1649
J4Q40_RS12905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J4Q40_RS12930	COG0702	epimerase
J4Q40_RS12945	COG1858	cytochrome C peroxidase
J4Q40_RS12985	COG3039	Transposase
J4Q40_RS12990	COG3039	Transposase
J4Q40_RS13035	COG0513	Belongs to the DEAD box helicase family
J4Q40_RS13040	COG3039	Transposase
J4Q40_RS13080	COG1136	(ABC) transporter
J4Q40_RS13090	COG3039	Transposase
J4Q40_RS13100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4Q40_RS13125	COG1755	Isoprenylcysteine carboxyl methyltransferase
J4Q40_RS13130	COG1304	FMN binding
J4Q40_RS13135	COG3039	Transposase
J4Q40_RS13150	COG4772	TonB-dependent receptor
J4Q40_RS13160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J4Q40_RS13175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4Q40_RS13215	COG0501	Belongs to the peptidase M48B family
J4Q40_RS13225	COG0187	DNA topoisomerase II activity
J4Q40_RS13240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J4Q40_RS13260	COG0726	polysaccharide deacetylase
J4Q40_RS13270	COG0671	phosphoesterase, PA-phosphatase related
J4Q40_RS13280	COG0584	glycerophosphoryl diester phosphodiesterase
J4Q40_RS13290	COG0861	Integral membrane protein TerC family
J4Q40_RS13295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4Q40_RS13310	COG2271	Major facilitator Superfamily
J4Q40_RS13315	COG1929	Belongs to the glycerate kinase type-1 family
J4Q40_RS13405	COG0477	Major facilitator Superfamily
J4Q40_RS13430	COG0302	gtp cyclohydrolase
J4Q40_RS13435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J4Q40_RS13480	COG2234	aminopeptidase activity
J4Q40_RS13490	COG4942	peptidase
J4Q40_RS13495	COG0793	Belongs to the peptidase S41A family
J4Q40_RS13545	COG0386	Belongs to the glutathione peroxidase family
J4Q40_RS13555	COG1322	Protein conserved in bacteria
J4Q40_RS13565	COG0531	amino acid
J4Q40_RS13580	COG0210	DNA helicase
J4Q40_RS13595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4Q40_RS13600	COG0583	DNA-binding transcription factor activity
J4Q40_RS13605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J4Q40_RS13625	COG2159	amidohydrolase
J4Q40_RS13655	COG3540	Alkaline phosphatase
J4Q40_RS13665	COG2091	lysine biosynthetic process via aminoadipic acid
J4Q40_RS13680	COG0708	Exodeoxyribonuclease III
J4Q40_RS13695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4Q40_RS13700	COG3162	membrane
J4Q40_RS13740	COG3507	Belongs to the glycosyl hydrolase 43 family
J4Q40_RS13760	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS13765	COG0179	Fumarylacetoacetate (FAA) hydrolase
J4Q40_RS13770	COG4948	Mandelate Racemase Muconate Lactonizing
J4Q40_RS13775	COG4807	Protein conserved in bacteria
J4Q40_RS13780	COG1643	Atp-dependent helicase
J4Q40_RS13790	COG1187	pseudouridine synthase activity
J4Q40_RS13800	COG0667	Aldo Keto reductase
J4Q40_RS13805	COG2130	NADP-dependent
J4Q40_RS13810	COG0656	L-ascorbic acid biosynthetic process
J4Q40_RS13845	COG1752	Esterase of the alpha-beta hydrolase superfamily
J4Q40_RS13855	COG1119	ATPase activity
J4Q40_RS13870	COG0517	IMP dehydrogenase activity
J4Q40_RS13870	COG1125	glycine betaine transport
J4Q40_RS13885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4Q40_RS13890	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
J4Q40_RS13895	COG3550	peptidyl-serine autophosphorylation
J4Q40_RS13900	COG1396	sequence-specific DNA binding
J4Q40_RS13920	COG0489	protein tyrosine kinase activity
J4Q40_RS13925	COG2062	phosphohistidine phosphatase, SixA
J4Q40_RS13935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4Q40_RS13980	COG1968	undecaprenyl-diphosphatase activity
J4Q40_RS13985	COG0174	glutamine synthetase
J4Q40_RS13990	COG0347	Belongs to the P(II) protein family
J4Q40_RS13995	COG0004	ammonium transporteR
J4Q40_RS14000	COG3852	Histidine kinase
J4Q40_RS14005	COG2204	response regulator
J4Q40_RS14010	COG2032	superoxide dismutase activity
J4Q40_RS14015	COG2032	superoxide dismutase activity
J4Q40_RS14060	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J4Q40_RS14065	COG1074	ATP-dependent DNA helicase activity
J4Q40_RS14075	COG3549	Plasmid maintenance system killer
J4Q40_RS14155	COG1764	response to oxidative stress
J4Q40_RS14160	COG1846	Transcriptional regulator
J4Q40_RS14250	COG2211	Major facilitator Superfamily
J4Q40_RS14270	COG3693	PFAM glycoside hydrolase, family 10
J4Q40_RS14295	COG0246	Mannitol dehydrogenase
J4Q40_RS14300	COG1472	Belongs to the glycosyl hydrolase 3 family
J4Q40_RS14310	COG4948	Mandelate Racemase Muconate Lactonizing
J4Q40_RS14320	COG3661	Belongs to the glycosyl hydrolase 67 family
J4Q40_RS14365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J4Q40_RS14375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4Q40_RS14385	COG0805	protein transport
J4Q40_RS14395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J4Q40_RS14395	COG0519	Catalyzes the synthesis of GMP from XMP
J4Q40_RS14410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4Q40_RS14425	COG0457	Tetratricopeptide repeat
J4Q40_RS14430	COG4771	TonB-dependent receptor
J4Q40_RS14445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J4Q40_RS14465	COG0523	cobalamin synthesis protein
J4Q40_RS14530	COG1960	acyl-CoA dehydrogenase activity
J4Q40_RS14535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J4Q40_RS14540	COG4770	biotin carboxylase activity
J4Q40_RS14590	COG2072	flavoprotein involved in K transport
J4Q40_RS14610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J4Q40_RS14660	COG0084	hydrolase, TatD family'
J4Q40_RS14675	COG0583	DNA-binding transcription factor activity
J4Q40_RS14680	COG2814	Major facilitator Superfamily
J4Q40_RS14690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J4Q40_RS14695	COG1902	pentaerythritol trinitrate reductase activity
J4Q40_RS14725	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS14745	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4Q40_RS14750	COG0583	DNA-binding transcription factor activity
J4Q40_RS14780	COG0702	epimerase
J4Q40_RS14785	COG1733	regulation of RNA biosynthetic process
J4Q40_RS14840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4Q40_RS14855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4Q40_RS14890	COG2911	Protein conserved in bacteria
J4Q40_RS14895	COG0729	surface antigen
J4Q40_RS14910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J4Q40_RS14915	COG3118	belongs to the thioredoxin family
J4Q40_RS14925	COG2884	Cell division ATP-binding protein ftsE
J4Q40_RS14930	COG2177	Part of the ABC transporter FtsEX involved in
J4Q40_RS14935	COG2201	protein-glutamate methylesterase activity
J4Q40_RS14940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J4Q40_RS14945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4Q40_RS14955	COG1252	NADH dehydrogenase
J4Q40_RS14980	COG0459	protein refolding
J4Q40_RS14990	COG4771	TonB-dependent receptor
J4Q40_RS15005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4Q40_RS15045	COG3386	PFAM SMP-30 Gluconolaconase
J4Q40_RS15060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J4Q40_RS15090	COG2353	YceI-like domain
J4Q40_RS15185	COG0408	coproporphyrinogen oxidase activity
J4Q40_RS15195	COG3039	Transposase
J4Q40_RS15220	COG0129	dihydroxy-acid dehydratase activity
J4Q40_RS15230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J4Q40_RS15280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4Q40_RS15285	COG0318	PFAM AMP-dependent synthetase and ligase
J4Q40_RS15290	COG0727	PFAM Uncharacterised protein family (UPF0153)
J4Q40_RS15295	COG0596	Alpha beta hydrolase
J4Q40_RS15310	COG3177	Filamentation induced by cAMP protein fic
J4Q40_RS15315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4Q40_RS15330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J4Q40_RS15355	COG4191	Histidine kinase
J4Q40_RS15360	COG0028	Belongs to the TPP enzyme family
J4Q40_RS15375	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J4Q40_RS15380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4Q40_RS15415	COG5383	Protein conserved in bacteria
J4Q40_RS15425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4Q40_RS15430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4Q40_RS15435	COG1473	amidohydrolase
J4Q40_RS15445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J4Q40_RS15445	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J4Q40_RS15450	COG3328	transposase activity
J4Q40_RS15460	COG3039	Transposase
J4Q40_RS15545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4Q40_RS15560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4Q40_RS15565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J4Q40_RS15575	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J4Q40_RS15580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J4Q40_RS15585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J4Q40_RS15635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J4Q40_RS15650	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J4Q40_RS15715	COG0358	DNA primase activity
J4Q40_RS15720	COG1295	ribonuclease BN
J4Q40_RS15730	COG1610	YqeY-like protein
J4Q40_RS15740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J4Q40_RS15745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J4Q40_RS15780	COG2133	pyrroloquinoline quinone binding
J4Q40_RS15785	COG4682	membrane
J4Q40_RS15820	COG0531	amino acid
J4Q40_RS15855	COG4948	Mandelate Racemase Muconate Lactonizing
J4Q40_RS15865	COG3023	N-Acetylmuramoyl-L-alanine amidase
J4Q40_RS15870	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J4Q40_RS15900	COG3039	Transposase
J4Q40_RS15950	COG0183	Belongs to the thiolase family
J4Q40_RS15990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J4Q40_RS16000	COG3483	tryptophan 2,3-dioxygenase activity
J4Q40_RS16005	COG3104	oligopeptide transport
J4Q40_RS16025	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J4Q40_RS16035	COG1320	monovalent cation:proton antiporter activity
J4Q40_RS16040	COG2212	antiporter activity
J4Q40_RS16050	COG0651	ATP synthesis coupled electron transport
J4Q40_RS16055	COG1006	Multisubunit Na H antiporter MnhC subunit
J4Q40_RS16060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4Q40_RS16060	COG2111	Na H antiporter
J4Q40_RS16095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J4Q40_RS16105	COG0456	acetyltransferase
J4Q40_RS16135	COG4221	oxidoreductase activity
J4Q40_RS16195	COG0697	spore germination
J4Q40_RS16200	COG4305	rare lipoprotein A
J4Q40_RS16205	COG5297	Belongs to the glycosyl hydrolase family 6
J4Q40_RS16215	COG1113	amino acid transport
J4Q40_RS16225	COG0598	Magnesium transport protein CorA
J4Q40_RS16295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J4Q40_RS16295	COG5297	Belongs to the glycosyl hydrolase family 6
J4Q40_RS16300	COG0659	secondary active sulfate transmembrane transporter activity
J4Q40_RS16335	COG3275	phosphorelay sensor kinase activity
J4Q40_RS16345	COG0181	hydroxymethylbilane synthase activity
J4Q40_RS16370	COG1505	serine-type exopeptidase activity
J4Q40_RS16385	COG0436	Aminotransferase
J4Q40_RS16415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J4Q40_RS16445	COG0308	aminopeptidase N
J4Q40_RS16450	COG2199	diguanylate cyclase activity
J4Q40_RS16495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4Q40_RS16500	COG1077	Cell shape determining protein MreB Mrl
J4Q40_RS16505	COG1792	Involved in formation and maintenance of cell shape
J4Q40_RS16520	COG0772	Belongs to the SEDS family
J4Q40_RS16565	COG2951	lytic endotransglycosylase activity
J4Q40_RS16570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4Q40_RS16575	COG1686	Belongs to the peptidase S11 family
J4Q40_RS16590	COG2921	Belongs to the UPF0250 family
J4Q40_RS16640	COG1051	belongs to the nudix hydrolase family
J4Q40_RS16640	COG1056	cytidyltransferase-related domain
J4Q40_RS16675	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J4Q40_RS16680	COG0673	inositol 2-dehydrogenase activity
J4Q40_RS16685	COG2823	Periplasmic or secreted lipoprotein
J4Q40_RS16690	COG4251	negative regulation of phosphorylation
J4Q40_RS16695	COG0784	Response regulator, receiver
J4Q40_RS16700	COG4191	Histidine kinase
J4Q40_RS16705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4Q40_RS16745	COG3250	beta-galactosidase activity
J4Q40_RS16760	COG2188	Transcriptional regulator
J4Q40_RS16770	COG1609	Transcriptional regulator
J4Q40_RS16775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J4Q40_RS16780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J4Q40_RS16790	COG1215	transferase activity, transferring glycosyl groups
J4Q40_RS16795	COG1649	PFAM Uncharacterised BCR, COG1649
J4Q40_RS16795	COG0726	polysaccharide deacetylase
J4Q40_RS16835	COG3039	Transposase
J4Q40_RS16885	COG3039	Transposase
J4Q40_RS16895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J4Q40_RS16900	COG3039	Transposase
J4Q40_RS16935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J4Q40_RS16955	COG2205	protein histidine kinase activity
J4Q40_RS16995	COG2205	protein histidine kinase activity
J4Q40_RS17045	COG0488	(ABC) transporter
J4Q40_RS17065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J4Q40_RS17085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4Q40_RS17085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4Q40_RS17105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J4Q40_RS17110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4Q40_RS17115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J4Q40_RS17135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J4Q40_RS17140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J4Q40_RS17150	COG2205	protein histidine kinase activity
J4Q40_RS17155	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS17160	COG0277	FAD linked oxidase domain protein
J4Q40_RS17165	COG1988	membrane-bound metal-dependent
J4Q40_RS17170	COG0792	nuclease activity
J4Q40_RS17205	COG0275	rRNA processing
J4Q40_RS17210	COG3116	cell division
J4Q40_RS17225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4Q40_RS17230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4Q40_RS17245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4Q40_RS17250	COG1181	Belongs to the D-alanine--D-alanine ligase family
J4Q40_RS17255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J4Q40_RS17270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J4Q40_RS17280	COG4942	peptidase
J4Q40_RS17280	COG1388	LysM domain
J4Q40_RS17295	COG0494	nUDIX hydrolase
J4Q40_RS17315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J4Q40_RS17325	COG0604	alcohol dehydrogenase
J4Q40_RS17325	COG3321	synthase
J4Q40_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS17370	COG2226	methyltransferase
J4Q40_RS17375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J4Q40_RS17420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J4Q40_RS17435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4Q40_RS17445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4Q40_RS17450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4Q40_RS17460	COG0667	Aldo Keto reductase
J4Q40_RS17500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J4Q40_RS17510	COG2175	clavaminate synthase activity
J4Q40_RS17520	COG4181	ATPase activity
J4Q40_RS17535	COG0642	Histidine kinase
J4Q40_RS17555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J4Q40_RS17575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J4Q40_RS17600	COG2967	ApaG domain
J4Q40_RS17605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J4Q40_RS17615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J4Q40_RS17630	COG0123	including yeast histone deacetylase and acetoin utilization protein
J4Q40_RS17635	COG2096	Adenosyltransferase
J4Q40_RS17645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4Q40_RS17650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4Q40_RS17690	COG0583	DNA-binding transcription factor activity
J4Q40_RS17695	COG0318	PFAM AMP-dependent synthetase and ligase
J4Q40_RS17705	COG1024	Enoyl-CoA hydratase
J4Q40_RS17725	COG3386	PFAM SMP-30 Gluconolaconase
J4Q40_RS17850	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4Q40_RS17850	COG1902	pentaerythritol trinitrate reductase activity
J4Q40_RS17855	COG0604	alcohol dehydrogenase
J4Q40_RS17880	COG0156	8-amino-7-oxononanoate synthase activity
J4Q40_RS17885	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J4Q40_RS17890	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J4Q40_RS17895	COG4208	sulfate ABC transporter
J4Q40_RS17900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J4Q40_RS17930	COG0406	alpha-ribazole phosphatase activity
J4Q40_RS17940	COG0285	dihydrofolate synthase activity
J4Q40_RS17960	COG2833	Protein of unknown function (DUF455)
J4Q40_RS17980	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4Q40_RS17985	COG0671	phosphoesterase, PA-phosphatase related
J4Q40_RS17990	COG0438	transferase activity, transferring glycosyl groups
J4Q40_RS18000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J4Q40_RS18015	COG4783	chaperone-mediated protein folding
J4Q40_RS18080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4Q40_RS18085	COG0583	DNA-binding transcription factor activity
J4Q40_RS18090	COG3634	alkyl hydroperoxide reductase activity
J4Q40_RS18100	COG2890	protein-(glutamine-N5) methyltransferase activity
J4Q40_RS18150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4Q40_RS18150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4Q40_RS18165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J4Q40_RS18190	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J4Q40_RS18215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4Q40_RS18225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4Q40_RS18255	COG1295	ribonuclease BN
J4Q40_RS18260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4Q40_RS18280	COG0521	Mo-molybdopterin cofactor biosynthetic process
J4Q40_RS18290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4Q40_RS18305	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J4Q40_RS18320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4Q40_RS18330	COG0193	aminoacyl-tRNA hydrolase activity
J4Q40_RS18335	COG0012	GTP binding
J4Q40_RS18365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4Q40_RS18370	COG0250	Participates in transcription elongation, termination and antitermination
J4Q40_RS18375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J4Q40_RS18385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J4Q40_RS18390	COG0222	ribosome binding
J4Q40_RS18395	COG0085	RNA polymerase activity
J4Q40_RS18400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J4Q40_RS18405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J4Q40_RS18410	COG0049	tRNA binding
J4Q40_RS18430	COG0051	transcription antitermination factor activity, RNA binding
J4Q40_RS18435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J4Q40_RS18440	COG0088	Forms part of the polypeptide exit tunnel
J4Q40_RS18445	COG0089	rRNA binding
J4Q40_RS18460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J4Q40_RS18470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J4Q40_RS18475	COG0255	Belongs to the universal ribosomal protein uL29 family
J4Q40_RS18480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J4Q40_RS18485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J4Q40_RS18495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J4Q40_RS18525	COG1841	ribosomal large subunit assembly
J4Q40_RS18535	COG0201	protein transport
J4Q40_RS18545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J4Q40_RS18550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J4Q40_RS18560	COG0203	ribosomal protein L17
J4Q40_RS18620	COG3551	Protein conserved in bacteria
J4Q40_RS18650	COG2194	sulfuric ester hydrolase activity
J4Q40_RS18660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J4Q40_RS18665	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS18670	COG0642	Histidine kinase
J4Q40_RS18680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J4Q40_RS18685	COG2894	cell division
J4Q40_RS18700	COG4585	Histidine kinase
J4Q40_RS18705	COG2197	response regulator
J4Q40_RS18730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J4Q40_RS18825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4Q40_RS18835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4Q40_RS18905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4Q40_RS19005	COG3179	chitinase
J4Q40_RS19185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J4Q40_RS19195	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J4Q40_RS19215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J4Q40_RS19220	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
J4Q40_RS19225	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
J4Q40_RS19240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J4Q40_RS19275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4Q40_RS19280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4Q40_RS19335	COG1297	OPT oligopeptide transporter protein
J4Q40_RS19340	COG3039	Transposase
J4Q40_RS19360	COG0823	Involved in the tonB-independent uptake of proteins
J4Q40_RS19360	COG1506	peptidase
J4Q40_RS19390	COG2207	Transcriptional regulator
J4Q40_RS19390	COG1917	Cupin 2, conserved barrel domain protein
J4Q40_RS19410	COG3039	Transposase
J4Q40_RS19430	COG0753	catalase activity
J4Q40_RS19470	COG0469	pyruvate kinase activity
J4Q40_RS19475	COG3588	fructose-bisphosphate aldolase
J4Q40_RS19480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J4Q40_RS19525	COG2198	Histidine kinase
J4Q40_RS19525	COG0784	Response regulator, receiver
J4Q40_RS19525	COG2205	protein histidine kinase activity
J4Q40_RS19545	COG0175	sulfate reduction
J4Q40_RS19550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4Q40_RS19555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4Q40_RS19560	COG0175	sulfate reduction
J4Q40_RS19565	COG0529	Catalyzes the synthesis of activated sulfate
J4Q40_RS19565	COG2895	sulfate adenylyltransferase (ATP) activity
J4Q40_RS19575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4Q40_RS19580	COG0308	aminopeptidase N
J4Q40_RS19600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4Q40_RS19630	COG1970	mechanosensitive ion channel activity
J4Q40_RS19660	COG0471	metal ion transport
J4Q40_RS19660	COG3273	potassium ion transport
J4Q40_RS19670	COG2022	thiamine diphosphate biosynthetic process
J4Q40_RS19735	COG3293	Transposase
J4Q40_RS19750	COG3039	Transposase
J4Q40_RS19755	COG3039	Transposase
J4Q40_RS19820	COG3118	belongs to the thioredoxin family
J4Q40_RS19845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J4Q40_RS19870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J4Q40_RS19895	COG2968	Membrane
J4Q40_RS19910	COG3164	Protein of unknown function
J4Q40_RS19920	COG0312	modulator of DNA gyrase
J4Q40_RS19925	COG3028	Belongs to the UPF0307 family
J4Q40_RS19930	COG0312	modulator of DNA gyrase
J4Q40_RS19955	COG0142	geranyltranstransferase activity
J4Q40_RS19960	COG1722	exodeoxyribonuclease VII activity
J4Q40_RS19965	COG0037	tRNA processing
J4Q40_RS19970	COG1785	Belongs to the alkaline phosphatase family
J4Q40_RS19975	COG1301	dicarboxylic acid transport
J4Q40_RS19990	COG0791	NLP P60 protein
J4Q40_RS19995	COG0791	NLP P60 protein
J4Q40_RS20000	COG1047	Peptidyl-prolyl cis-trans
J4Q40_RS20005	COG2311	Membrane
J4Q40_RS20010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4Q40_RS20050	COG0489	protein tyrosine kinase activity
J4Q40_RS20055	COG0717	Belongs to the dCTP deaminase family
J4Q40_RS20075	COG0412	Dienelactone hydrolase
J4Q40_RS20085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4Q40_RS20125	COG2890	protein-(glutamine-N5) methyltransferase activity
J4Q40_RS20130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J4Q40_RS20135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4Q40_RS20140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4Q40_RS20160	COG0101	tRNA pseudouridine synthase activity
J4Q40_RS20165	COG0135	phosphoribosylanthranilate isomerase activity
J4Q40_RS20190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J4Q40_RS20195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4Q40_RS20245	COG0149	triose-phosphate isomerase activity
J4Q40_RS20260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4Q40_RS20270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4Q40_RS20275	COG0649	NAD binding
J4Q40_RS20280	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J4Q40_RS20285	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J4Q40_RS20290	COG1034	ATP synthesis coupled electron transport
J4Q40_RS20295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J4Q40_RS20325	COG1007	ATP synthesis coupled electron transport
J4Q40_RS20335	COG0779	Required for maturation of 30S ribosomal subunits
J4Q40_RS20340	COG0195	Participates in both transcription termination and antitermination
J4Q40_RS20360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J4Q40_RS20365	COG1185	polyribonucleotide nucleotidyltransferase activity
J4Q40_RS20400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J4Q40_RS20410	COG2095	MarC family integral membrane protein
J4Q40_RS20425	COG1611	Belongs to the LOG family
J4Q40_RS20465	COG4969	Belongs to the N-Me-Phe pilin family
J4Q40_RS20470	COG0556	nucleotide-excision repair
J4Q40_RS20505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J4Q40_RS20575	COG0438	transferase activity, transferring glycosyl groups
J4Q40_RS20580	COG0438	transferase activity, transferring glycosyl groups
J4Q40_RS20590	COG0438	transferase activity, transferring glycosyl groups
J4Q40_RS20630	COG3040	lipid binding
J4Q40_RS20715	COG4191	Histidine kinase
J4Q40_RS20715	COG0784	Response regulator, receiver
J4Q40_RS20735	COG0552	protein localization to endoplasmic reticulum
J4Q40_RS20745	COG3938	Belongs to the proline racemase family
J4Q40_RS20750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4Q40_RS20765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4Q40_RS20775	COG0006	proline dipeptidase activity
J4Q40_RS20790	COG0531	amino acid
J4Q40_RS20840	COG4206	TonB-dependent receptor
J4Q40_RS20865	COG4206	TonB-dependent receptor
J4Q40_RS20935	COG0746	molybdenum cofactor guanylyltransferase activity
J4Q40_RS20960	COG1648	precorrin-2 dehydrogenase activity
J4Q40_RS20960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J4Q40_RS21005	COG3039	Transposase
J4Q40_RS21010	COG3039	Transposase
J4Q40_RS21045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J4Q40_RS21065	COG3039	Transposase
J4Q40_RS21070	COG1054	Belongs to the UPF0176 family
J4Q40_RS21085	COG1530	ribonuclease E activity
J4Q40_RS21095	COG3064	Membrane
J4Q40_RS21100	COG0428	transporter
J4Q40_RS21105	COG0428	transporter
J4Q40_RS21115	COG2154	pterin-4-alpha-carbinolamine dehydratase
J4Q40_RS21120	COG0316	Belongs to the HesB IscA family
J4Q40_RS21120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J4Q40_RS21165	COG3039	Transposase
J4Q40_RS21180	COG3039	Transposase
J4Q40_RS21290	COG0631	protein serine/threonine phosphatase activity
J4Q40_RS21295	COG0515	serine threonine protein kinase
J4Q40_RS21330	COG1858	cytochrome C peroxidase
J4Q40_RS21380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4Q40_RS21385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4Q40_RS21450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4Q40_RS21470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4Q40_RS21485	COG1595	DNA-templated transcription, initiation
J4Q40_RS21535	COG2244	polysaccharide biosynthetic process
J4Q40_RS21565	COG2264	protein methyltransferase activity
J4Q40_RS21575	COG0438	transferase activity, transferring glycosyl groups
J4Q40_RS21595	COG1136	(ABC) transporter
J4Q40_RS21600	COG1132	(ABC) transporter
J4Q40_RS21610	COG0477	Major facilitator Superfamily
J4Q40_RS21620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4Q40_RS21635	COG1253	flavin adenine dinucleotide binding
J4Q40_RS21645	COG0306	phosphate transporter
J4Q40_RS21650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J4Q40_RS21675	COG0504	CTP synthase activity
J4Q40_RS21680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J4Q40_RS21690	COG0148	phosphopyruvate hydratase activity
J4Q40_RS21695	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J4Q40_RS21710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J4Q40_RS21720	COG2840	Smr protein MutS2
J4Q40_RS21725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J4Q40_RS21730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J4Q40_RS21735	COG1238	metal cluster binding
J4Q40_RS21750	COG1534	Rna-binding protein
J4Q40_RS21755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J4Q40_RS21765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J4Q40_RS21780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4Q40_RS21785	COG1546	Belongs to the CinA family
J4Q40_RS21800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J4Q40_RS21805	COG2137	regulation of response to DNA damage stimulus
J4Q40_RS21810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J4Q40_RS21815	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J4Q40_RS21835	COG0305	Participates in initiation and elongation during chromosome replication
J4Q40_RS21840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J4Q40_RS21860	COG1741	Belongs to the pirin family
J4Q40_RS21865	COG0583	DNA-binding transcription factor activity
J4Q40_RS21895	COG0351	phosphomethylpyrimidine kinase
J4Q40_RS21905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J4Q40_RS21910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J4Q40_RS21925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4Q40_RS21935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J4Q40_RS21940	COG3734	2-keto-3-deoxy-galactonokinase
J4Q40_RS21950	COG4948	Mandelate Racemase Muconate Lactonizing
J4Q40_RS21955	COG0800	Aldolase
J4Q40_RS21970	COG1501	Belongs to the glycosyl hydrolase 31 family
J4Q40_RS21980	COG1070	Carbohydrate kinase
J4Q40_RS21990	COG0477	Major facilitator Superfamily
J4Q40_RS22010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J4Q40_RS22060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4Q40_RS22065	COG2258	MOSC domain
J4Q40_RS22075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J4Q40_RS22080	COG0505	Belongs to the CarA family
J4Q40_RS22090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4Q40_RS22095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4Q40_RS22105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4Q40_RS22165	COG2205	protein histidine kinase activity
J4Q40_RS22165	COG2198	Histidine kinase
J4Q40_RS22165	COG0784	Response regulator, receiver
J4Q40_RS22170	COG1024	Enoyl-CoA hydratase
J4Q40_RS22175	COG0318	PFAM AMP-dependent synthetase and ligase
J4Q40_RS22205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4Q40_RS22235	COG0840	transmembrane signaling receptor activity
J4Q40_RS22255	COG0835	chemotaxis
J4Q40_RS22270	COG0840	transmembrane signaling receptor activity
J4Q40_RS22275	COG0840	transmembrane signaling receptor activity
J4Q40_RS22280	COG0840	transmembrane signaling receptor activity
J4Q40_RS22285	COG0840	transmembrane signaling receptor activity
J4Q40_RS22295	COG0840	transmembrane signaling receptor activity
J4Q40_RS22305	COG0840	transmembrane signaling receptor activity
J4Q40_RS22315	COG0840	transmembrane signaling receptor activity
J4Q40_RS22335	COG0745	RESPONSE REGULATOR receiver
J4Q40_RS22345	COG0835	chemotaxis
J4Q40_RS22355	COG1360	Flagellar Motor Protein
J4Q40_RS22360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J4Q40_RS22380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J4Q40_RS22390	COG4771	TonB-dependent receptor
J4Q40_RS22425	COG3039	Transposase
J4Q40_RS22540	COG3039	Transposase
J4Q40_RS22555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4Q40_RS22555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4Q40_RS22560	COG1105	Belongs to the carbohydrate kinase PfkB family
J4Q40_RS22565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4Q40_RS22565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4Q40_RS22570	COG1609	Transcriptional regulator
J4Q40_RS22590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4Q40_RS22595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4Q40_RS22605	COG2902	Dehydrogenase
J4Q40_RS22610	COG3039	Transposase
J4Q40_RS22620	COG5002	protein histidine kinase activity
J4Q40_RS22620	COG2205	protein histidine kinase activity
J4Q40_RS22620	COG0784	Response regulator, receiver
J4Q40_RS22625	COG2733	membrane
J4Q40_RS22635	COG1121	(ABC) transporter
J4Q40_RS22640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J4Q40_RS22645	COG2223	nitrite transmembrane transporter activity
J4Q40_RS22655	COG0243	molybdopterin cofactor binding
J4Q40_RS22665	COG0477	Major facilitator Superfamily
J4Q40_RS22675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4Q40_RS22680	COG0174	glutamine synthetase
J4Q40_RS22715	COG3842	ATPase activity
J4Q40_RS22725	COG1177	transmembrane transport
J4Q40_RS22735	COG1012	belongs to the aldehyde dehydrogenase family
J4Q40_RS22750	COG4535	Mg2 and Co2 transporter CorC
J4Q40_RS22770	COG1702	phosphate starvation-inducible protein PhoH
J4Q40_RS22795	COG0741	lytic transglycosylase activity
J4Q40_RS22800	COG0723	plastoquinol--plastocyanin reductase activity
J4Q40_RS22805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J4Q40_RS22810	COG2857	Cytochrome c1
J4Q40_RS22815	COG0625	glutathione transferase activity
J4Q40_RS22820	COG2969	positive regulation of protein catabolic process
J4Q40_RS22855	COG3328	transposase activity
J4Q40_RS22930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4Q40_RS22955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4Q40_RS22960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J4Q40_RS22960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4Q40_RS22965	COG0802	atpase or kinase
J4Q40_RS22970	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4Q40_RS22975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J4Q40_RS22995	COG1028	Short-chain dehydrogenase reductase Sdr
J4Q40_RS23015	COG2081	HI0933 family
J4Q40_RS23020	COG4681	YaeQ
J4Q40_RS23025	COG1671	Belongs to the UPF0178 family
J4Q40_RS23035	COG0625	glutathione transferase activity
J4Q40_RS23055	COG0513	Belongs to the DEAD box helicase family
J4Q40_RS23060	COG0488	(ABC) transporter
J4Q40_RS23080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J4Q40_RS23085	COG0483	inositol monophosphate 1-phosphatase activity
J4Q40_RS23100	COG3300	MHYT domain
J4Q40_RS23100	COG5001	Diguanylate cyclase
J4Q40_RS23105	COG1509	lysine 2,3-aminomutase activity
J4Q40_RS23120	COG0402	S-adenosylhomocysteine deaminase activity
J4Q40_RS23125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J4Q40_RS23150	COG4677	pectinesterase activity
J4Q40_RS23160	COG3039	Transposase
J4Q40_RS23195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4Q40_RS23220	COG2166	iron-sulfur cluster assembly
J4Q40_RS23235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4Q40_RS23240	COG0137	argininosuccinate synthase activity
J4Q40_RS23250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4Q40_RS23255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J4Q40_RS23270	COG0165	Argininosuccinate lyase
J4Q40_RS23290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J4Q40_RS23325	COG3039	Transposase
J4Q40_RS23340	COG4988	ABC transporter
J4Q40_RS23345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J4Q40_RS23355	COG3039	Transposase