locus-tag	class	description
B4599_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4599_RS00030	COG0187	DNA topoisomerase II activity
B4599_RS00040	COG0501	Belongs to the peptidase M48B family
B4599_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4599_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B4599_RS00100	COG4772	TonB-dependent receptor
B4599_RS00115	COG3039	Transposase
B4599_RS00120	COG1304	FMN binding
B4599_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4599_RS00160	COG3039	Transposase
B4599_RS00165	COG1136	(ABC) transporter
B4599_RS00215	COG3039	Transposase
B4599_RS00225	COG0513	Belongs to the DEAD box helicase family
B4599_RS00280	COG3039	Transposase
B4599_RS00340	COG1858	cytochrome C peroxidase
B4599_RS00350	COG0702	epimerase
B4599_RS00375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B4599_RS00395	COG1649	PFAM Uncharacterised BCR, COG1649
B4599_RS00400	COG2354	Protein conserved in bacteria
B4599_RS00410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B4599_RS00425	COG1511	domain protein
B4599_RS00425	COG3264	Mechanosensitive ion channel
B4599_RS00505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4599_RS00615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4599_RS00625	COG0642	Histidine kinase
B4599_RS00635	COG1090	epimerase
B4599_RS00645	COG3039	Transposase
B4599_RS00670	COG2826	transposase and inactivated derivatives, IS30 family
B4599_RS00725	COG1136	(ABC) transporter
B4599_RS00770	COG1272	protein, Hemolysin III
B4599_RS00775	COG1205	dead DEAH box helicase
B4599_RS00775	COG1111	helicase
B4599_RS00840	COG0070	glutamate synthase
B4599_RS00840	COG0069	glutamate synthase activity
B4599_RS00840	COG0067	glutamate synthase
B4599_RS00845	COG0493	'glutamate synthase
B4599_RS00895	COG1609	Transcriptional regulator
B4599_RS00930	COG0366	Alpha amylase catalytic
B4599_RS00935	COG0366	Alpha amylase catalytic
B4599_RS00990	COG0606	chelatase, subunit chli
B4599_RS01035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4599_RS01040	COG1166	arginine decarboxylase activity
B4599_RS01105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4599_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS01155	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B4599_RS01170	COG0210	DNA helicase
B4599_RS01185	COG3132	Protein of unknown function, DUF480
B4599_RS01190	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B4599_RS01195	COG0284	orotidine-5'-phosphate decarboxylase activity
B4599_RS01230	COG2937	Belongs to the GPAT DAPAT family
B4599_RS01235	COG0604	alcohol dehydrogenase
B4599_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS01235	COG3321	synthase
B4599_RS01260	COG2755	lipolytic protein G-D-S-L family
B4599_RS01275	COG3186	Phenylalanine-4-hydroxylase
B4599_RS01280	COG1522	sequence-specific DNA binding
B4599_RS01330	COG1064	alcohol dehydrogenase
B4599_RS01340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_RS01350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_RS01360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_RS01385	COG3039	Transposase
B4599_RS01390	COG0676	glucose-6-phosphate 1-epimerase activity
B4599_RS01455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4599_RS01480	COG2853	Lipoprotein
B4599_RS01495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B4599_RS01500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B4599_RS01505	COG1127	ABC transporter
B4599_RS01580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_RS01595	COG3265	gluconokinase activity
B4599_RS01600	COG2211	Major facilitator Superfamily
B4599_RS01605	COG3459	Glycosyltransferase 36 associated
B4599_RS01620	COG2205	protein histidine kinase activity
B4599_RS01630	COG1414	Transcriptional regulator
B4599_RS01635	COG0738	Major facilitator superfamily
B4599_RS01640	COG3254	rhamnose metabolic process
B4599_RS01670	COG0339	signal peptide processing
B4599_RS01700	COG0564	pseudouridine synthase activity
B4599_RS01710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B4599_RS01725	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4599_RS01740	COG3039	Transposase
B4599_RS01835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4599_RS01845	COG0842	Transport permease protein
B4599_RS01850	COG1131	(ABC) transporter
B4599_RS01855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4599_RS01875	COG1476	TRANSCRIPTIONal
B4599_RS01885	COG4555	ABC transporter
B4599_RS01920	COG0625	glutathione transferase activity
B4599_RS01970	COG0583	DNA-binding transcription factor activity
B4599_RS02005	COG1199	ATP-dependent helicase activity
B4599_RS02025	COG1566	PFAM secretion protein HlyD family protein
B4599_RS02055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4599_RS02095	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4599_RS02095	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4599_RS02100	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B4599_RS02115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4599_RS02155	COG3237	CsbD-like
B4599_RS02160	COG0180	Tryptophanyl-tRNA synthetase
B4599_RS02165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4599_RS02215	COG0753	catalase activity
B4599_RS02220	COG1595	DNA-templated transcription, initiation
B4599_RS02230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4599_RS02240	COG0628	permease
B4599_RS02255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B4599_RS02260	COG1040	competence protein
B4599_RS02265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4599_RS02270	COG0156	8-amino-7-oxononanoate synthase activity
B4599_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS02300	COG0463	Glycosyl transferase, family 2
B4599_RS02310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4599_RS02315	COG3100	YcgL domain-containing protein
B4599_RS02335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4599_RS02355	COG2239	Acts as a magnesium transporter
B4599_RS02365	COG0045	succinate-CoA ligase (ADP-forming) activity
B4599_RS02365	COG1042	CoA-binding domain protein
B4599_RS02365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4599_RS02375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4599_RS02385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4599_RS02420	COG3485	protocatechuate 3,4-dioxygenase
B4599_RS02425	COG3485	protocatechuate 3,4-dioxygenase
B4599_RS02440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4599_RS02445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4599_RS02470	COG4221	oxidoreductase activity
B4599_RS02485	COG0018	arginyl-trna synthetase
B4599_RS02490	COG2003	Belongs to the UPF0758 family
B4599_RS02495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4599_RS02520	COG0463	Glycosyl transferase, family 2
B4599_RS02535	COG1475	DNA binding
B4599_RS02540	COG1192	Involved in chromosome partitioning
B4599_RS02555	COG0708	Exodeoxyribonuclease III
B4599_RS02560	COG2211	Major facilitator Superfamily
B4599_RS02575	COG0739	heme binding
B4599_RS02620	COG0745	RESPONSE REGULATOR receiver
B4599_RS02665	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B4599_RS02690	COG2814	Major facilitator Superfamily
B4599_RS02705	COG1289	transmembrane transporter activity
B4599_RS02715	COG0577	efflux transmembrane transporter activity
B4599_RS02715	COG1136	(ABC) transporter
B4599_RS02720	COG0151	Belongs to the GarS family
B4599_RS02730	COG0419	ATPase involved in DNA repair
B4599_RS02745	COG2267	carboxylic ester hydrolase activity
B4599_RS02755	COG2267	carboxylic ester hydrolase activity
B4599_RS02760	COG2453	phosphatase
B4599_RS02760	COG0671	phosphoesterase, PA-phosphatase related
B4599_RS02775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B4599_RS02835	COG0439	Biotin carboxylase
B4599_RS02845	COG0511	ligase activity, forming carbon-carbon bonds
B4599_RS02850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4599_RS02870	COG1324	tolerance protein
B4599_RS02875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4599_RS02900	COG0534	Mate efflux family protein
B4599_RS02905	COG0616	signal peptide processing
B4599_RS02915	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS02930	COG0009	L-threonylcarbamoyladenylate synthase
B4599_RS02935	COG1754	DNA topoisomerase type I activity
B4599_RS02935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4599_RS02950	COG2922	Belongs to the Smg family
B4599_RS02955	COG0758	DNA mediated transformation
B4599_RS02960	COG1652	LysM domain
B4599_RS02965	COG0242	peptide deformylase activity
B4599_RS02970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4599_RS02975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4599_RS02975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4599_RS03025	COG1560	Kdo2-lipid A biosynthetic process
B4599_RS03035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4599_RS03275	COG1294	oxidase, subunit
B4599_RS03280	COG1271	oxidase subunit
B4599_RS03295	COG2204	response regulator
B4599_RS03325	COG2972	Histidine kinase
B4599_RS03340	COG0531	amino acid
B4599_RS03360	COG3590	peptidase
B4599_RS03375	COG0667	Aldo Keto reductase
B4599_RS03390	COG3384	dioxygenase
B4599_RS03400	COG1573	uracil-dna glycosylase
B4599_RS03410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B4599_RS03425	COG0025	NhaP-type Na H and K H
B4599_RS03430	COG1131	(ABC) transporter
B4599_RS03435	COG0842	Transport permease protein
B4599_RS03455	COG1404	Belongs to the peptidase S8 family
B4599_RS03470	COG0745	RESPONSE REGULATOR receiver
B4599_RS03520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_RS03545	COG2202	Pas domain
B4599_RS03545	COG2205	protein histidine kinase activity
B4599_RS03580	COG2813	Specifically methylates the guanine in position
B4599_RS03585	COG1187	pseudouridine synthase activity
B4599_RS03590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4599_RS03625	COG0697	spore germination
B4599_RS03635	COG2011	ABC-type metal ion transport system permease component
B4599_RS03665	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4599_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4599_RS03695	COG0356	it plays a direct role in the translocation of protons across the membrane
B4599_RS03705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B4599_RS03715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4599_RS03720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4599_RS03725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4599_RS03730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B4599_RS03785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_RS03790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4599_RS03845	COG0339	signal peptide processing
B4599_RS03885	COG1956	GAF domain-containing protein
B4599_RS03890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4599_RS03900	COG0720	synthase
B4599_RS03910	COG0513	Belongs to the DEAD box helicase family
B4599_RS03955	COG0626	cystathionine gamma-synthase activity
B4599_RS04005	COG3328	transposase activity
B4599_RS04030	COG2086	electron transfer activity
B4599_RS04055	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B4599_RS04055	COG0662	Cupin 2, conserved barrel domain protein
B4599_RS04060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4599_RS04100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B4599_RS04100	COG3218	ABC-type transport auxiliary lipoprotein component
B4599_RS04105	COG1127	ABC transporter
B4599_RS04110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B4599_RS04125	COG0442	prolyl-tRNA aminoacylation
B4599_RS04135	COG1183	phosphatidylcholine synthase activity
B4599_RS04165	COG3039	Transposase
B4599_RS04235	COG0525	valine-tRNA ligase activity
B4599_RS04250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4599_RS04260	COG0795	lipopolysaccharide-transporting ATPase activity
B4599_RS04275	COG4974	Belongs to the 'phage' integrase family
B4599_RS04280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4599_RS04285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4599_RS04285	COG0047	phosphoribosylformylglycinamidine synthase activity
B4599_RS04295	COG5295	Hep Hag repeat protein
B4599_RS04315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4599_RS04325	COG1459	type II secretion system
B4599_RS04330	COG2165	general secretion pathway protein
B4599_RS04335	COG4970	Tfp pilus assembly protein FimT
B4599_RS04340	COG2165	general secretion pathway protein
B4599_RS04345	COG4795	General secretion pathway protein
B4599_RS04350	COG3156	type II secretion system protein K
B4599_RS04355	COG3166	PFAM Fimbrial assembly family protein
B4599_RS04370	COG1450	Type ii and iii secretion system protein
B4599_RS04385	COG2188	Transcriptional regulator
B4599_RS04440	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B4599_RS04445	COG1518	maintenance of DNA repeat elements
B4599_RS04490	COG1399	metal-binding, possibly nucleic acid-binding protein
B4599_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS04520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4599_RS04530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4599_RS04535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4599_RS04560	COG3829	transcription factor binding
B4599_RS04575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4599_RS04645	COG2826	transposase and inactivated derivatives, IS30 family
B4599_RS04655	COG0678	peroxiredoxin activity
B4599_RS04675	COG0330	HflC and HflK could
B4599_RS04680	COG0330	HflC and HflK could
B4599_RS04695	COG0308	aminopeptidase N
B4599_RS04745	COG1560	Kdo2-lipid A biosynthetic process
B4599_RS04750	COG1519	Transferase
B4599_RS04755	COG1538	Outer membrane efflux protein
B4599_RS04760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B4599_RS04785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4599_RS04790	COG0066	3-isopropylmalate dehydratase activity
B4599_RS04825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4599_RS04835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B4599_RS04840	COG3710	Transcriptional regulator
B4599_RS04865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B4599_RS04885	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B4599_RS04915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4599_RS04925	COG3781	membrane
B4599_RS04945	COG0625	glutathione transferase activity
B4599_RS04955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4599_RS04960	COG1217	gtp-binding protein TYPA
B4599_RS04980	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B4599_RS05115	COG3039	Transposase
B4599_RS05140	COG0584	glycerophosphoryl diester phosphodiesterase
B4599_RS05165	COG0473	3-isopropylmalate dehydrogenase activity
B4599_RS05220	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4599_RS05260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4599_RS05285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4599_RS05295	COG0631	protein serine/threonine phosphatase activity
B4599_RS05365	COG0582	viral genome integration into host DNA
B4599_RS05375	COG0859	PFAM glycosyl transferase family 9
B4599_RS05380	COG3642	lipopolysaccharide core region biosynthetic process
B4599_RS05385	COG1234	tRNA 3'-trailer cleavage
B4599_RS05390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4599_RS05400	COG0315	cyclic pyranopterin monophosphate synthase activity
B4599_RS05405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B4599_RS05410	COG0314	molybdopterin synthase activity
B4599_RS05440	COG0537	adenosine 5'-monophosphoramidase activity
B4599_RS05460	COG0714	Associated with various cellular activities
B4599_RS05480	COG0242	peptide deformylase activity
B4599_RS05530	COG3039	Transposase
B4599_RS05560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B4599_RS05565	COG0726	polysaccharide deacetylase
B4599_RS05615	COG2211	Major facilitator Superfamily
B4599_RS05625	COG1609	Transcriptional regulator
B4599_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS05635	COG2851	Citrate transporter
B4599_RS05655	COG0642	Histidine kinase
B4599_RS05665	COG2197	response regulator
B4599_RS05685	COG0583	DNA-binding transcription factor activity
B4599_RS05700	COG4191	Histidine kinase
B4599_RS05720	COG0280	phosphate acetyltransferase
B4599_RS05720	COG0281	malic enzyme
B4599_RS05755	COG0352	thiamine-phosphate diphosphorylase activity
B4599_RS05760	COG1773	rubredoxin
B4599_RS05765	COG2912	Transglutaminase-like superfamily
B4599_RS05785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4599_RS05810	COG0006	proline dipeptidase activity
B4599_RS05845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4599_RS05860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B4599_RS05865	COG1561	YicC-like family, N-terminal region
B4599_RS05890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4599_RS05900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4599_RS05930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B4599_RS05980	COG0714	Associated with various cellular activities
B4599_RS06000	COG2304	oxidoreductase activity
B4599_RS06020	COG1301	dicarboxylic acid transport
B4599_RS06025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B4599_RS06035	COG0739	heme binding
B4599_RS06040	COG1376	ErfK ybiS ycfS ynhG family protein
B4599_RS06065	COG1022	Amp-dependent synthetase and ligase
B4599_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS06090	COG0642	Histidine kinase
B4599_RS06110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B4599_RS06115	COG4149	molybdate abc transporter
B4599_RS06120	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4599_RS06125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4599_RS06125	COG3453	Protein conserved in bacteria
B4599_RS06155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4599_RS06175	COG2205	protein histidine kinase activity
B4599_RS06180	COG0745	RESPONSE REGULATOR receiver
B4599_RS06230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4599_RS06235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4599_RS06280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4599_RS06345	COG2201	protein-glutamate methylesterase activity
B4599_RS06380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4599_RS06395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4599_RS06410	COG1842	Phage shock protein A
B4599_RS06435	COG0754	glutathionylspermidine amidase activity
B4599_RS06505	COG0531	amino acid
B4599_RS06510	COG2197	response regulator
B4599_RS06525	COG1113	amino acid transport
B4599_RS06545	COG1271	oxidase subunit
B4599_RS06550	COG1294	oxidase, subunit
B4599_RS06560	COG2239	Acts as a magnesium transporter
B4599_RS06570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4599_RS06575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4599_RS06585	COG1660	Displays ATPase and GTPase activities
B4599_RS06590	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B4599_RS06595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4599_RS06610	COG1137	ATPase activity
B4599_RS06615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B4599_RS06625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B4599_RS06635	COG0271	Belongs to the BolA IbaG family
B4599_RS06645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4599_RS06665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4599_RS06680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4599_RS06690	COG0628	permease
B4599_RS06700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4599_RS06705	COG3178	'Phosphotransferase
B4599_RS06720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4599_RS06725	COG1555	photosystem II stabilization
B4599_RS06775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4599_RS06785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4599_RS06810	COG0228	four-way junction DNA binding
B4599_RS06815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4599_RS06820	COG0336	Belongs to the RNA methyltransferase TrmD family
B4599_RS06835	COG0534	Mate efflux family protein
B4599_RS06880	COG0542	response to heat
B4599_RS06920	COG4206	TonB-dependent receptor
B4599_RS06980	COG0019	diaminopimelate decarboxylase activity
B4599_RS06990	COG2814	Major facilitator Superfamily
B4599_RS06995	COG4264	IucA IucC family
B4599_RS07005	COG4772	TonB-dependent receptor
B4599_RS07020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4599_RS07020	COG4651	solute:proton antiporter activity
B4599_RS07055	COG0488	(ABC) transporter
B4599_RS07080	COG2755	lipolytic protein G-D-S-L family
B4599_RS07080	COG0657	acetylesterase activity
B4599_RS07100	COG2207	Transcriptional regulator
B4599_RS07105	COG0326	Molecular chaperone. Has ATPase activity
B4599_RS07135	COG3328	transposase activity
B4599_RS07140	COG0174	glutamine synthetase
B4599_RS07145	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B4599_RS07155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B4599_RS07170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4599_RS07200	COG2146	nitrite reductase [NAD(P)H] activity
B4599_RS07215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4599_RS07220	COG0719	Fe-S assembly protein
B4599_RS07225	COG0396	ATPase activity
B4599_RS07230	COG0719	Fe-S assembly protein
B4599_RS07235	COG1959	2 iron, 2 sulfur cluster binding
B4599_RS07255	COG0693	protein deglycase activity
B4599_RS07300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4599_RS07335	COG0519	Catalyzes the synthesis of GMP from XMP
B4599_RS07345	COG1678	Uncharacterized ACR, COG1678
B4599_RS07350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4599_RS07365	COG1764	response to oxidative stress
B4599_RS07375	COG0384	phenazine biosynthesis protein PhzF
B4599_RS07385	COG0527	aspartate kinase activity
B4599_RS07415	COG0142	geranyltranstransferase activity
B4599_RS07420	COG0629	single-stranded DNA binding
B4599_RS07425	COG2203	Gaf domain
B4599_RS07425	COG3706	GGDEF domain
B4599_RS07425	COG4251	negative regulation of phosphorylation
B4599_RS07425	COG5001	Diguanylate cyclase
B4599_RS07465	COG2879	small protein
B4599_RS07470	COG1966	Carbon starvation protein
B4599_RS07475	COG1741	Belongs to the pirin family
B4599_RS07560	COG1741	Belongs to the pirin family
B4599_RS07570	COG1515	deoxyribonuclease V activity
B4599_RS07590	COG3590	peptidase
B4599_RS07605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4599_RS07610	COG2202	Pas domain
B4599_RS07610	COG2200	EAL domain
B4599_RS07610	COG2199	diguanylate cyclase activity
B4599_RS07615	COG0835	chemotaxis
B4599_RS07620	COG0840	transmembrane signaling receptor activity
B4599_RS07625	COG2198	Histidine kinase
B4599_RS07625	COG0643	Histidine kinase
B4599_RS07635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4599_RS07645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B4599_RS07660	COG3039	Transposase
B4599_RS07675	COG2205	protein histidine kinase activity
B4599_RS07700	COG3039	Transposase
B4599_RS07725	COG3039	Transposase
B4599_RS07760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4599_RS07765	COG0735	belongs to the Fur family
B4599_RS07825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4599_RS07830	COG0084	hydrolase, TatD family'
B4599_RS07845	COG1960	acyl-CoA dehydrogenase activity
B4599_RS07860	COG0367	asparagine synthase
B4599_RS07870	COG0305	Participates in initiation and elongation during chromosome replication
B4599_RS07875	COG0415	Belongs to the DNA photolyase family
B4599_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS07995	COG5001	Diguanylate cyclase
B4599_RS07995	COG5002	protein histidine kinase activity
B4599_RS08000	COG1187	pseudouridine synthase activity
B4599_RS08025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B4599_RS08035	COG0475	glutathione-regulated potassium exporter activity
B4599_RS08040	COG5002	protein histidine kinase activity
B4599_RS08040	COG5000	phosphorelay sensor kinase activity
B4599_RS08045	COG0745	RESPONSE REGULATOR receiver
B4599_RS08075	COG1132	(ABC) transporter
B4599_RS08100	COG3039	Transposase
B4599_RS08115	COG3039	Transposase
B4599_RS08160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4599_RS08170	COG4969	Belongs to the N-Me-Phe pilin family
B4599_RS08175	COG2194	sulfuric ester hydrolase activity
B4599_RS08215	COG0045	succinate-CoA ligase (ADP-forming) activity
B4599_RS08220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4599_RS08235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4599_RS08235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4599_RS08240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_RS08245	COG0564	pseudouridine synthase activity
B4599_RS08270	COG3387	PFAM Glycoside hydrolase 15-related
B4599_RS08275	COG1877	trehalose-phosphatase activity
B4599_RS08315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B4599_RS08335	COG1595	DNA-templated transcription, initiation
B4599_RS08345	COG1946	Acyl-CoA thioesterase
B4599_RS08360	COG0824	Thioesterase
B4599_RS08365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4599_RS08375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B4599_RS08380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4599_RS08385	COG0268	Binds directly to 16S ribosomal RNA
B4599_RS08390	COG0728	peptidoglycan biosynthetic process
B4599_RS08395	COG0196	riboflavin kinase activity
B4599_RS08405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4599_RS08410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B4599_RS08425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4599_RS08430	COG1845	cytochrome c oxidase, subunit III
B4599_RS08435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4599_RS08455	COG3209	COG3209 Rhs family protein
B4599_RS08465	COG3209	COG3209 Rhs family protein
B4599_RS08580	COG0632	four-way junction helicase activity
B4599_RS08590	COG2255	four-way junction helicase activity
B4599_RS08595	COG0824	Thioesterase
B4599_RS08605	COG0848	biopolymer transport protein
B4599_RS08620	COG2885	chlorophyll binding
B4599_RS08630	COG0602	queuosine metabolic process
B4599_RS08640	COG1187	pseudouridine synthase activity
B4599_RS08695	COG3039	Transposase
B4599_RS08710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B4599_RS08735	COG0514	ATP-dependent DNA helicase (RecQ)
B4599_RS08745	COG0783	Belongs to the Dps family
B4599_RS08750	COG1643	Atp-dependent helicase
B4599_RS08805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4599_RS08815	COG1215	transferase activity, transferring glycosyl groups
B4599_RS08820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4599_RS08830	COG1199	ATP-dependent helicase activity
B4599_RS08840	COG1397	ADP-ribosylglycohydrolase
B4599_RS08850	COG0189	ligase activity
B4599_RS08865	COG0835	chemotaxis
B4599_RS08870	COG0840	transmembrane signaling receptor activity
B4599_RS08875	COG0643	Histidine kinase
B4599_RS08875	COG0784	Response regulator, receiver
B4599_RS08875	COG2198	Histidine kinase
B4599_RS08920	COG1446	asparaginase
B4599_RS08925	COG3142	Participates in the control of copper homeostasis
B4599_RS08980	COG3537	Alpha-1,2-mannosidase
B4599_RS09050	COG1472	Belongs to the glycosyl hydrolase 3 family
B4599_RS09070	COG1388	LysM domain
B4599_RS09070	COG3858	chitin binding
B4599_RS09085	COG0837	glucose binding
B4599_RS09090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4599_RS09100	COG0494	nUDIX hydrolase
B4599_RS09110	COG3956	TIGRFAM MazG family protein
B4599_RS09125	COG0330	HflC and HflK could
B4599_RS09140	COG0509	glycine decarboxylation via glycine cleavage system
B4599_RS09175	COG1960	acyl-CoA dehydrogenase activity
B4599_RS09185	COG1309	transcriptional regulator
B4599_RS09190	COG4771	TonB-dependent receptor
B4599_RS09200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4599_RS09210	COG0463	Glycosyl transferase, family 2
B4599_RS09230	COG1272	protein, Hemolysin III
B4599_RS09240	COG0739	heme binding
B4599_RS09245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4599_RS09250	COG0626	cystathionine gamma-synthase activity
B4599_RS09260	COG1760	l-serine dehydratase
B4599_RS09275	COG2353	YceI-like domain
B4599_RS09285	COG2353	YceI-like domain
B4599_RS09355	COG1960	acyl-CoA dehydrogenase activity
B4599_RS09360	COG1024	Enoyl-CoA hydratase
B4599_RS09380	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4599_RS09380	COG1024	Enoyl-CoA hydratase
B4599_RS09395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4599_RS09425	COG1381	Involved in DNA repair and RecF pathway recombination
B4599_RS09440	COG2954	triphosphatase activity
B4599_RS09455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4599_RS09460	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B4599_RS09465	COG3046	protein related to deoxyribodipyrimidine photolyase
B4599_RS09475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B4599_RS09480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B4599_RS09485	COG1278	Cold shock
B4599_RS09505	COG1201	RNA secondary structure unwinding
B4599_RS09510	COG1793	dna ligase
B4599_RS09520	COG1793	dna ligase
B4599_RS09520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B4599_RS09550	COG0183	Belongs to the thiolase family
B4599_RS09575	COG1451	nucleotide metabolic process
B4599_RS09590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4599_RS09635	COG1047	Peptidyl-prolyl cis-trans
B4599_RS09650	COG2824	Alkylphosphonate utilization operon protein PhnA
B4599_RS09665	COG1902	pentaerythritol trinitrate reductase activity
B4599_RS09670	COG2814	Major facilitator Superfamily
B4599_RS09730	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4599_RS09730	COG0392	lysyltransferase activity
B4599_RS09740	COG0251	oxidation-reduction process
B4599_RS09745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4599_RS09760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4599_RS09785	COG1595	DNA-templated transcription, initiation
B4599_RS09805	COG2878	Part of a membrane complex involved in electron transport
B4599_RS09815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4599_RS09815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4599_RS09835	COG0833	amino acid
B4599_RS09840	COG2040	homocysteine
B4599_RS09855	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4599_RS09890	COG0529	Catalyzes the synthesis of activated sulfate
B4599_RS09890	COG2895	sulfate adenylyltransferase (ATP) activity
B4599_RS09935	COG1981	membrane
B4599_RS09960	COG1131	(ABC) transporter
B4599_RS09965	COG4771	TonB-dependent receptor
B4599_RS09975	COG0825	malonyl-CoA metabolic process
B4599_RS09995	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B4599_RS10000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4599_RS10020	COG0750	zinc metalloprotease
B4599_RS10030	COG0575	Belongs to the CDS family
B4599_RS10040	COG0233	cytoplasmic translational termination
B4599_RS10055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B4599_RS10115	COG1393	Belongs to the ArsC family
B4599_RS10130	COG0367	asparagine synthase
B4599_RS10145	COG4774	siderophore transport
B4599_RS10185	COG1566	PFAM secretion protein HlyD family protein
B4599_RS10190	COG2814	Major facilitator Superfamily
B4599_RS10235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B4599_RS10245	COG1960	acyl-CoA dehydrogenase activity
B4599_RS10270	COG2914	Belongs to the UPF0125 (RnfH) family
B4599_RS10280	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_RS10290	COG0497	DNA recombination
B4599_RS10300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4599_RS10305	COG0443	Heat shock 70 kDa protein
B4599_RS10310	COG0484	heat shock protein binding
B4599_RS10320	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B4599_RS10325	COG0287	Prephenate dehydrogenase
B4599_RS10325	COG1605	Chorismate mutase
B4599_RS10345	COG0583	DNA-binding transcription factor activity
B4599_RS10360	COG1132	(ABC) transporter
B4599_RS10395	COG2850	peptidyl-arginine hydroxylation
B4599_RS10475	COG1131	(ABC) transporter
B4599_RS10480	COG1725	Transcriptional regulator
B4599_RS10490	COG0386	Belongs to the glutathione peroxidase family
B4599_RS10505	COG2900	Belongs to the SlyX family
B4599_RS10520	COG1609	Transcriptional regulator
B4599_RS10530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4599_RS10540	COG0646	methionine synthase
B4599_RS10540	COG1410	methionine synthase
B4599_RS10545	COG1410	methionine synthase
B4599_RS10545	COG0646	methionine synthase
B4599_RS10550	COG2226	methyltransferase
B4599_RS10555	COG1960	acyl-CoA dehydrogenase activity
B4599_RS10585	COG0557	exoribonuclease II activity
B4599_RS10605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4599_RS10620	COG3039	Transposase
B4599_RS10645	COG3328	transposase activity
B4599_RS10655	COG1278	Cold shock
B4599_RS10670	COG3039	Transposase
B4599_RS10730	COG3039	Transposase
B4599_RS10780	COG3039	Transposase
B4599_RS10790	COG0583	DNA-binding transcription factor activity
B4599_RS10850	COG2201	protein-glutamate methylesterase activity
B4599_RS10885	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B4599_RS10895	COG0531	amino acid
B4599_RS10900	COG0531	amino acid
B4599_RS10910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4599_RS10915	COG0277	FAD linked oxidase domain protein
B4599_RS10980	COG0436	Aminotransferase
B4599_RS11005	COG1187	pseudouridine synthase activity
B4599_RS11010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4599_RS11015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4599_RS11020	COG2350	Protein conserved in bacteria
B4599_RS11050	COG1175	transmembrane transport
B4599_RS11055	COG0395	ABC-type sugar transport system, permease component
B4599_RS11080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4599_RS11085	COG3039	Transposase
B4599_RS11095	COG2957	Belongs to the agmatine deiminase family
B4599_RS11110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4599_RS11115	COG0539	negative regulation of cytoplasmic translation
B4599_RS11120	COG0776	regulation of translation
B4599_RS11130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B4599_RS11135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4599_RS11145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4599_RS11165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4599_RS11180	COG3002	Belongs to the UPF0753 family
B4599_RS11185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4599_RS11190	COG0583	DNA-binding transcription factor activity
B4599_RS11220	COG0583	DNA-binding transcription factor activity
B4599_RS11245	COG1914	H( )-stimulated, divalent metal cation uptake system
B4599_RS11265	COG0668	transmembrane transport
B4599_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS11325	COG1183	phosphatidylcholine synthase activity
B4599_RS11335	COG3243	poly(R)-hydroxyalkanoic acid synthase
B4599_RS11350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_RS11350	COG0723	plastoquinol--plastocyanin reductase activity
B4599_RS11360	COG2183	response to ionizing radiation
B4599_RS11375	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B4599_RS11390	COG0671	phosphoesterase, PA-phosphatase related
B4599_RS11415	COG1794	racemase activity, acting on amino acids and derivatives
B4599_RS11425	COG0697	spore germination
B4599_RS11450	COG1012	belongs to the aldehyde dehydrogenase family
B4599_RS11485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4599_RS11500	COG0124	histidyl-tRNA synthetase
B4599_RS11520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B4599_RS11535	COG0131	Imidazoleglycerol-phosphate dehydratase
B4599_RS11535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B4599_RS11545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B4599_RS11555	COG0140	phosphoribosyl-ATP diphosphatase activity
B4599_RS11555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4599_RS11595	COG0653	protein targeting
B4599_RS11690	COG2201	protein-glutamate methylesterase activity
B4599_RS11700	COG2801	Transposase and inactivated derivatives
B4599_RS11715	COG3039	Transposase
B4599_RS11740	COG3328	transposase activity
B4599_RS11775	COG0322	excinuclease ABC activity
B4599_RS11785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4599_RS11795	COG1663	tetraacyldisaccharide 4'-kinase activity
B4599_RS11810	COG0811	peptide transport
B4599_RS11840	COG4591	ABC-type transport system involved in lipoprotein release permease component
B4599_RS11855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4599_RS11870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B4599_RS11885	COG0354	folic acid binding
B4599_RS11900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4599_RS11910	COG0363	glucosamine-6-phosphate deaminase activity
B4599_RS11915	COG0129	dihydroxy-acid dehydratase activity
B4599_RS11920	COG0800	Aldolase
B4599_RS11950	COG0784	Response regulator, receiver
B4599_RS11950	COG2205	protein histidine kinase activity
B4599_RS11950	COG5002	protein histidine kinase activity
B4599_RS12035	COG0386	Belongs to the glutathione peroxidase family
B4599_RS12125	COG4251	negative regulation of phosphorylation
B4599_RS12125	COG5001	Diguanylate cyclase
B4599_RS12125	COG3706	GGDEF domain
B4599_RS12125	COG2203	Gaf domain
B4599_RS12145	COG1472	Belongs to the glycosyl hydrolase 3 family
B4599_RS12180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B4599_RS12195	COG0617	tRNA 3'-terminal CCA addition
B4599_RS12205	COG1469	GTP cyclohydrolase I activity
B4599_RS12210	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4599_RS12260	COG4566	intracellular signal transduction
B4599_RS12290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4599_RS12295	COG0077	Prephenate dehydratase
B4599_RS12295	COG1605	Chorismate mutase
B4599_RS12300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4599_RS12305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4599_RS12350	COG1228	amidohydrolase
B4599_RS12355	COG2986	histidine ammonia-lyase
B4599_RS12365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B4599_RS12390	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B4599_RS12405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B4599_RS12420	COG3115	cell septum assembly
B4599_RS12430	COG0359	binds to the 23S rRNA
B4599_RS12440	COG0360	Binds together with S18 to 16S ribosomal RNA
B4599_RS12445	COG0316	Belongs to the HesB IscA family
B4599_RS12480	COG0288	reversible hydration of carbon dioxide
B4599_RS12505	COG2925	Exonuclease
B4599_RS12515	COG0667	Aldo Keto reductase
B4599_RS12540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4599_RS12540	COG0116	Belongs to the methyltransferase superfamily
B4599_RS12585	COG0494	nUDIX hydrolase
B4599_RS12595	COG1024	Enoyl-CoA hydratase
B4599_RS12605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4599_RS12620	COG3039	Transposase
B4599_RS12660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4599_RS12665	COG0573	inorganic phosphate transmembrane transporter activity
B4599_RS12680	COG0704	Plays a role in the regulation of phosphate uptake
B4599_RS12690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4599_RS12705	COG3328	transposase activity
B4599_RS12740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4599_RS12745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4599_RS12750	COG1862	Preprotein translocase
B4599_RS12755	COG0343	queuine tRNA-ribosyltransferase activity
B4599_RS12835	COG0405	Gamma-glutamyltransferase
B4599_RS12840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B4599_RS12855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4599_RS12860	COG0742	ribosomal rna small subunit methyltransferase
B4599_RS12880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4599_RS12915	COG3039	Transposase
B4599_RS12945	COG0303	'Molybdopterin
B4599_RS12955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_RS12965	COG1426	Protein conserved in bacteria
B4599_RS12975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4599_RS12990	COG1024	Enoyl-CoA hydratase
B4599_RS12990	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4599_RS12995	COG0183	Belongs to the thiolase family
B4599_RS13000	COG0038	chloride channel
B4599_RS13020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4599_RS13045	COG1674	ftsk spoiiie
B4599_RS13050	COG0492	ferredoxin-NADP+ reductase activity
B4599_RS13075	COG0542	response to heat
B4599_RS13090	COG0482	sulfurtransferase activity
B4599_RS13115	COG5001	Diguanylate cyclase
B4599_RS13120	COG4585	Histidine kinase
B4599_RS13130	COG5002	protein histidine kinase activity
B4599_RS13150	COG0835	chemotaxis
B4599_RS13150	COG0784	Response regulator, receiver
B4599_RS13160	COG1558	bacterial-type flagellum-dependent cell motility
B4599_RS13165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B4599_RS13175	COG4787	bacterial-type flagellum-dependent cell motility
B4599_RS13215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4599_RS13220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B4599_RS13250	COG2201	protein-glutamate methylesterase activity
B4599_RS13270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4599_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS13315	COG1677	Flagellar hook-basal body complex protein FliE
B4599_RS13365	COG3190	flagellar
B4599_RS13385	COG1684	flagellar biosynthetic protein fliR
B4599_RS13440	COG0643	Histidine kinase
B4599_RS13440	COG0784	Response regulator, receiver
B4599_RS13440	COG2198	Histidine kinase
B4599_RS13480	COG3039	Transposase
B4599_RS13490	COG3209	COG3209 Rhs family protein
B4599_RS13500	COG3039	Transposase
B4599_RS13510	COG3039	Transposase
B4599_RS13600	COG3039	Transposase
B4599_RS13610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4599_RS13615	COG4988	ABC transporter
B4599_RS13630	COG3039	Transposase
B4599_RS13665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B4599_RS13685	COG0165	Argininosuccinate lyase
B4599_RS13700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B4599_RS13705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4599_RS13715	COG0137	argininosuccinate synthase activity
B4599_RS13720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4599_RS13735	COG2166	iron-sulfur cluster assembly
B4599_RS13760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4599_RS13800	COG3039	Transposase
B4599_RS13815	COG4677	pectinesterase activity
B4599_RS13845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4599_RS13850	COG0402	S-adenosylhomocysteine deaminase activity
B4599_RS13865	COG1509	lysine 2,3-aminomutase activity
B4599_RS13870	COG3300	MHYT domain
B4599_RS13870	COG5001	Diguanylate cyclase
B4599_RS13885	COG0483	inositol monophosphate 1-phosphatase activity
B4599_RS13890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4599_RS13915	COG0488	(ABC) transporter
B4599_RS13920	COG0513	Belongs to the DEAD box helicase family
B4599_RS13940	COG0625	glutathione transferase activity
B4599_RS13950	COG1671	Belongs to the UPF0178 family
B4599_RS13955	COG4681	YaeQ
B4599_RS13960	COG2081	HI0933 family
B4599_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS14005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4599_RS14010	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4599_RS14015	COG0802	atpase or kinase
B4599_RS14020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B4599_RS14020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4599_RS14025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4599_RS14050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_RS14135	COG3328	transposase activity
B4599_RS14180	COG2969	positive regulation of protein catabolic process
B4599_RS14185	COG0625	glutathione transferase activity
B4599_RS14190	COG2857	Cytochrome c1
B4599_RS14195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4599_RS14200	COG0723	plastoquinol--plastocyanin reductase activity
B4599_RS14210	COG0741	lytic transglycosylase activity
B4599_RS14235	COG1702	phosphate starvation-inducible protein PhoH
B4599_RS14255	COG4535	Mg2 and Co2 transporter CorC
B4599_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
B4599_RS14280	COG1177	transmembrane transport
B4599_RS14290	COG3842	ATPase activity
B4599_RS14330	COG0174	glutamine synthetase
B4599_RS14335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_RS14345	COG0477	Major facilitator Superfamily
B4599_RS14355	COG0243	molybdopterin cofactor binding
B4599_RS14365	COG2223	nitrite transmembrane transporter activity
B4599_RS14375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4599_RS14380	COG1121	(ABC) transporter
B4599_RS14390	COG2733	membrane
B4599_RS14395	COG0784	Response regulator, receiver
B4599_RS14395	COG5002	protein histidine kinase activity
B4599_RS14395	COG2205	protein histidine kinase activity
B4599_RS14405	COG3039	Transposase
B4599_RS14415	COG2902	Dehydrogenase
B4599_RS14425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_RS14430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_RS14450	COG1609	Transcriptional regulator
B4599_RS14455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4599_RS14455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4599_RS14460	COG1105	Belongs to the carbohydrate kinase PfkB family
B4599_RS14465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4599_RS14465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4599_RS14480	COG3039	Transposase
B4599_RS14625	COG3039	Transposase
B4599_RS14665	COG4771	TonB-dependent receptor
B4599_RS14675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4599_RS14695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4599_RS14700	COG1360	Flagellar Motor Protein
B4599_RS14710	COG0835	chemotaxis
B4599_RS14720	COG0745	RESPONSE REGULATOR receiver
B4599_RS14745	COG0840	transmembrane signaling receptor activity
B4599_RS14760	COG0840	transmembrane signaling receptor activity
B4599_RS14770	COG0840	transmembrane signaling receptor activity
B4599_RS14780	COG0840	transmembrane signaling receptor activity
B4599_RS14785	COG0840	transmembrane signaling receptor activity
B4599_RS14790	COG0840	transmembrane signaling receptor activity
B4599_RS14795	COG0840	transmembrane signaling receptor activity
B4599_RS14815	COG0835	chemotaxis
B4599_RS14840	COG0840	transmembrane signaling receptor activity
B4599_RS14875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4599_RS14905	COG0318	PFAM AMP-dependent synthetase and ligase
B4599_RS14910	COG1024	Enoyl-CoA hydratase
B4599_RS14915	COG2205	protein histidine kinase activity
B4599_RS14915	COG2198	Histidine kinase
B4599_RS14915	COG0784	Response regulator, receiver
B4599_RS14985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4599_RS14995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4599_RS15000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4599_RS15010	COG0505	Belongs to the CarA family
B4599_RS15015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4599_RS15025	COG2258	MOSC domain
B4599_RS15030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4599_RS15080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4599_RS15100	COG0477	Major facilitator Superfamily
B4599_RS15110	COG1070	Carbohydrate kinase
B4599_RS15120	COG1501	Belongs to the glycosyl hydrolase 31 family
B4599_RS15135	COG0800	Aldolase
B4599_RS15140	COG4948	Mandelate Racemase Muconate Lactonizing
B4599_RS15150	COG3734	2-keto-3-deoxy-galactonokinase
B4599_RS15155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B4599_RS15165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4599_RS15180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4599_RS15185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4599_RS15195	COG0351	phosphomethylpyrimidine kinase
B4599_RS15225	COG0583	DNA-binding transcription factor activity
B4599_RS15230	COG1741	Belongs to the pirin family
B4599_RS15250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B4599_RS15255	COG0305	Participates in initiation and elongation during chromosome replication
B4599_RS15280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B4599_RS15285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4599_RS15290	COG2137	regulation of response to DNA damage stimulus
B4599_RS15300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B4599_RS15315	COG1546	Belongs to the CinA family
B4599_RS15320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4599_RS15335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4599_RS15345	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B4599_RS15350	COG1534	Rna-binding protein
B4599_RS15365	COG1238	metal cluster binding
B4599_RS15370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B4599_RS15375	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B4599_RS15380	COG2840	Smr protein MutS2
B4599_RS15395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B4599_RS15410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B4599_RS15415	COG0148	phosphopyruvate hydratase activity
B4599_RS15425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B4599_RS15430	COG0504	CTP synthase activity
B4599_RS15455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B4599_RS15460	COG0306	phosphate transporter
B4599_RS15475	COG1253	flavin adenine dinucleotide binding
B4599_RS15490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4599_RS15510	COG0477	Major facilitator Superfamily
B4599_RS15520	COG1132	(ABC) transporter
B4599_RS15525	COG1136	(ABC) transporter
B4599_RS15545	COG0438	transferase activity, transferring glycosyl groups
B4599_RS15555	COG2264	protein methyltransferase activity
B4599_RS15585	COG2244	polysaccharide biosynthetic process
B4599_RS15635	COG1595	DNA-templated transcription, initiation
B4599_RS15650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4599_RS15670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4599_RS15725	COG2201	protein-glutamate methylesterase activity
B4599_RS15745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_RS15750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_RS15805	COG1858	cytochrome C peroxidase
B4599_RS15840	COG0515	serine threonine protein kinase
B4599_RS15845	COG0631	protein serine/threonine phosphatase activity
B4599_RS15955	COG3039	Transposase
B4599_RS15975	COG3039	Transposase
B4599_RS16025	COG0316	Belongs to the HesB IscA family
B4599_RS16025	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4599_RS16030	COG2154	pterin-4-alpha-carbinolamine dehydratase
B4599_RS16040	COG0428	transporter
B4599_RS16045	COG0428	transporter
B4599_RS16050	COG3064	Membrane
B4599_RS16060	COG1530	ribonuclease E activity
B4599_RS16080	COG1054	Belongs to the UPF0176 family
B4599_RS16085	COG3039	Transposase
B4599_RS16105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B4599_RS16145	COG3039	Transposase
B4599_RS16155	COG3039	Transposase
B4599_RS16185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4599_RS16185	COG1648	precorrin-2 dehydrogenase activity
B4599_RS16210	COG0746	molybdenum cofactor guanylyltransferase activity
B4599_RS16290	COG4206	TonB-dependent receptor
B4599_RS16320	COG4206	TonB-dependent receptor
B4599_RS16370	COG0531	amino acid
B4599_RS16385	COG0006	proline dipeptidase activity
B4599_RS16395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4599_RS16410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_RS16415	COG3938	Belongs to the proline racemase family
B4599_RS16425	COG0552	protein localization to endoplasmic reticulum
B4599_RS16450	COG0784	Response regulator, receiver
B4599_RS16450	COG4191	Histidine kinase
B4599_RS16540	COG3040	lipid binding
B4599_RS16580	COG0438	transferase activity, transferring glycosyl groups
B4599_RS16590	COG0438	transferase activity, transferring glycosyl groups
B4599_RS16595	COG0438	transferase activity, transferring glycosyl groups
B4599_RS16665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4599_RS16695	COG0556	nucleotide-excision repair
B4599_RS16700	COG4969	Belongs to the N-Me-Phe pilin family
B4599_RS16750	COG1611	Belongs to the LOG family
B4599_RS16765	COG2095	MarC family integral membrane protein
B4599_RS16775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B4599_RS16810	COG1185	polyribonucleotide nucleotidyltransferase activity
B4599_RS16815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4599_RS16835	COG0195	Participates in both transcription termination and antitermination
B4599_RS16840	COG0779	Required for maturation of 30S ribosomal subunits
B4599_RS16850	COG1007	ATP synthesis coupled electron transport
B4599_RS16880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B4599_RS16885	COG1034	ATP synthesis coupled electron transport
B4599_RS16890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B4599_RS16895	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B4599_RS16900	COG0649	NAD binding
B4599_RS16905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4599_RS16915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4599_RS16930	COG0149	triose-phosphate isomerase activity
B4599_RS16980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4599_RS16985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4599_RS17010	COG0135	phosphoribosylanthranilate isomerase activity
B4599_RS17015	COG0101	tRNA pseudouridine synthase activity
B4599_RS17035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4599_RS17040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4599_RS17045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4599_RS17050	COG2890	protein-(glutamine-N5) methyltransferase activity
B4599_RS17080	COG0433	COG0433 Predicted ATPase
B4599_RS17085	COG2826	transposase and inactivated derivatives, IS30 family
B4599_RS17105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4599_RS17115	COG0412	Dienelactone hydrolase
B4599_RS17140	COG0717	Belongs to the dCTP deaminase family
B4599_RS17145	COG0489	protein tyrosine kinase activity
B4599_RS17190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_RS17195	COG2311	Membrane
B4599_RS17200	COG1047	Peptidyl-prolyl cis-trans
B4599_RS17205	COG0791	NLP P60 protein
B4599_RS17210	COG0791	NLP P60 protein
B4599_RS17225	COG1301	dicarboxylic acid transport
B4599_RS17230	COG1785	Belongs to the alkaline phosphatase family
B4599_RS17235	COG0037	tRNA processing
B4599_RS17240	COG1722	exodeoxyribonuclease VII activity
B4599_RS17245	COG0142	geranyltranstransferase activity
B4599_RS17270	COG0312	modulator of DNA gyrase
B4599_RS17275	COG3028	Belongs to the UPF0307 family
B4599_RS17280	COG0312	modulator of DNA gyrase
B4599_RS17290	COG3164	Protein of unknown function
B4599_RS17305	COG2968	Membrane
B4599_RS17330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B4599_RS17355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4599_RS17385	COG3118	belongs to the thioredoxin family
B4599_RS17465	COG3039	Transposase
B4599_RS17470	COG3039	Transposase
B4599_RS17565	COG2022	thiamine diphosphate biosynthetic process
B4599_RS17580	COG0471	metal ion transport
B4599_RS17580	COG3273	potassium ion transport
B4599_RS17610	COG1970	mechanosensitive ion channel activity
B4599_RS17635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4599_RS17665	COG0308	aminopeptidase N
B4599_RS17670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_RS17685	COG2895	sulfate adenylyltransferase (ATP) activity
B4599_RS17685	COG0529	Catalyzes the synthesis of activated sulfate
B4599_RS17690	COG0175	sulfate reduction
B4599_RS17695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4599_RS17700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4599_RS17705	COG0175	sulfate reduction
B4599_RS17725	COG2205	protein histidine kinase activity
B4599_RS17725	COG2198	Histidine kinase
B4599_RS17725	COG0784	Response regulator, receiver
B4599_RS17770	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B4599_RS17775	COG3588	fructose-bisphosphate aldolase
B4599_RS17780	COG0469	pyruvate kinase activity
B4599_RS17835	COG0753	catalase activity
B4599_RS17860	COG3039	Transposase
B4599_RS17885	COG2207	Transcriptional regulator
B4599_RS17885	COG1917	Cupin 2, conserved barrel domain protein
B4599_RS17905	COG0823	Involved in the tonB-independent uptake of proteins
B4599_RS17905	COG1506	peptidase
B4599_RS17930	COG3039	Transposase
B4599_RS17935	COG1297	OPT oligopeptide transporter protein
B4599_RS18045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4599_RS18060	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
B4599_RS18065	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
B4599_RS18070	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4599_RS18090	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B4599_RS18105	COG0732	type I restriction modification DNA specificity domain
B4599_RS18300	COG3039	Transposase
B4599_RS18400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_RS18465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_RS18475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_RS18565	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4599_RS18580	COG2197	response regulator
B4599_RS18585	COG4585	Histidine kinase
B4599_RS18605	COG2894	cell division
B4599_RS18610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B4599_RS18620	COG0642	Histidine kinase
B4599_RS18625	COG0745	RESPONSE REGULATOR receiver
B4599_RS18630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4599_RS18640	COG2194	sulfuric ester hydrolase activity
B4599_RS18670	COG3551	Protein conserved in bacteria
B4599_RS18735	COG0203	ribosomal protein L17
B4599_RS18745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4599_RS18750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B4599_RS18760	COG0201	protein transport
B4599_RS18770	COG1841	ribosomal large subunit assembly
B4599_RS18800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B4599_RS18810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B4599_RS18815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4599_RS18820	COG0255	Belongs to the universal ribosomal protein uL29 family
B4599_RS18825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4599_RS18835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B4599_RS18850	COG0089	rRNA binding
B4599_RS18855	COG0088	Forms part of the polypeptide exit tunnel
B4599_RS18860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4599_RS18865	COG0051	transcription antitermination factor activity, RNA binding
B4599_RS18885	COG0049	tRNA binding
B4599_RS18890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4599_RS18895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4599_RS18900	COG0085	RNA polymerase activity
B4599_RS18905	COG0222	ribosome binding
B4599_RS18910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4599_RS18920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B4599_RS18930	COG0250	Participates in transcription elongation, termination and antitermination
B4599_RS18935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4599_RS18965	COG0012	GTP binding
B4599_RS18970	COG0193	aminoacyl-tRNA hydrolase activity
B4599_RS18980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4599_RS18995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B4599_RS19010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4599_RS19020	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4599_RS19040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4599_RS19045	COG1295	ribonuclease BN
B4599_RS19075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4599_RS19085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4599_RS19115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B4599_RS19140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B4599_RS19155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4599_RS19155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4599_RS19205	COG2890	protein-(glutamine-N5) methyltransferase activity
B4599_RS19215	COG3634	alkyl hydroperoxide reductase activity
B4599_RS19220	COG0583	DNA-binding transcription factor activity
B4599_RS19230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4599_RS19310	COG4783	chaperone-mediated protein folding
B4599_RS19325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B4599_RS19335	COG0438	transferase activity, transferring glycosyl groups
B4599_RS19340	COG0671	phosphoesterase, PA-phosphatase related
B4599_RS19345	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B4599_RS19365	COG2833	Protein of unknown function (DUF455)
B4599_RS19385	COG0285	dihydrofolate synthase activity
B4599_RS19395	COG0406	alpha-ribazole phosphatase activity
B4599_RS19430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B4599_RS19435	COG4208	sulfate ABC transporter
B4599_RS19440	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B4599_RS19445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B4599_RS19450	COG0156	8-amino-7-oxononanoate synthase activity
B4599_RS19480	COG0604	alcohol dehydrogenase
B4599_RS19485	COG1902	pentaerythritol trinitrate reductase activity
B4599_RS19485	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4599_RS19625	COG3386	PFAM SMP-30 Gluconolaconase
B4599_RS19645	COG1024	Enoyl-CoA hydratase
B4599_RS19655	COG0318	PFAM AMP-dependent synthetase and ligase
B4599_RS19660	COG0583	DNA-binding transcription factor activity
B4599_RS19700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4599_RS19705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4599_RS19715	COG2096	Adenosyltransferase
B4599_RS19720	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4599_RS19735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B4599_RS19745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4599_RS19750	COG2967	ApaG domain
B4599_RS19775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B4599_RS19795	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4599_RS19810	COG0642	Histidine kinase
B4599_RS19825	COG4181	ATPase activity
B4599_RS19835	COG2175	clavaminate synthase activity
B4599_RS19845	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B4599_RS19885	COG0667	Aldo Keto reductase
B4599_RS19895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4599_RS19900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4599_RS19920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4599_RS19935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4599_RS19990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B4599_RS19995	COG2226	methyltransferase
B4599_RS20050	COG0604	alcohol dehydrogenase
B4599_RS20050	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS20050	COG3321	synthase
B4599_RS20065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4599_RS20085	COG0494	nUDIX hydrolase
B4599_RS20100	COG4942	peptidase
B4599_RS20100	COG1388	LysM domain
B4599_RS20110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B4599_RS20125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4599_RS20130	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4599_RS20135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4599_RS20155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4599_RS20170	COG3116	cell division
B4599_RS20175	COG0275	rRNA processing
B4599_RS20210	COG0792	nuclease activity
B4599_RS20215	COG1988	membrane-bound metal-dependent
B4599_RS20220	COG0277	FAD linked oxidase domain protein
B4599_RS20225	COG0745	RESPONSE REGULATOR receiver
B4599_RS20230	COG2205	protein histidine kinase activity
B4599_RS20240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B4599_RS20245	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B4599_RS20270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4599_RS20275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4599_RS20280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4599_RS20300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4599_RS20300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4599_RS20320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4599_RS20340	COG0488	(ABC) transporter
B4599_RS20390	COG2205	protein histidine kinase activity
B4599_RS20425	COG2205	protein histidine kinase activity
B4599_RS20445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B4599_RS20480	COG3039	Transposase
B4599_RS20485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4599_RS20500	COG3039	Transposase
B4599_RS20555	COG3039	Transposase
B4599_RS20605	COG1649	PFAM Uncharacterised BCR, COG1649
B4599_RS20605	COG0726	polysaccharide deacetylase
B4599_RS20610	COG1215	transferase activity, transferring glycosyl groups
B4599_RS20620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4599_RS20625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4599_RS20630	COG1609	Transcriptional regulator
B4599_RS20640	COG2188	Transcriptional regulator
B4599_RS20655	COG3250	beta-galactosidase activity
B4599_RS20695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4599_RS20700	COG4191	Histidine kinase
B4599_RS20705	COG0784	Response regulator, receiver
B4599_RS20710	COG4251	negative regulation of phosphorylation
B4599_RS20715	COG2823	Periplasmic or secreted lipoprotein
B4599_RS20720	COG0673	inositol 2-dehydrogenase activity
B4599_RS20725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4599_RS20760	COG1056	cytidyltransferase-related domain
B4599_RS20760	COG1051	belongs to the nudix hydrolase family
B4599_RS20795	COG2921	Belongs to the UPF0250 family
B4599_RS20810	COG1686	Belongs to the peptidase S11 family
B4599_RS20820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4599_RS20825	COG2951	lytic endotransglycosylase activity
B4599_RS20860	COG0772	Belongs to the SEDS family
B4599_RS20875	COG1792	Involved in formation and maintenance of cell shape
B4599_RS20880	COG1077	Cell shape determining protein MreB Mrl
B4599_RS20885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4599_RS20890	COG3039	Transposase
B4599_RS20940	COG2199	diguanylate cyclase activity
B4599_RS20945	COG0308	aminopeptidase N
B4599_RS20975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B4599_RS21005	COG0436	Aminotransferase
B4599_RS21020	COG1505	serine-type exopeptidase activity
B4599_RS21045	COG0181	hydroxymethylbilane synthase activity
B4599_RS21055	COG3275	phosphorelay sensor kinase activity
B4599_RS21100	COG0659	secondary active sulfate transmembrane transporter activity
B4599_RS21105	COG5297	Belongs to the glycosyl hydrolase family 6
B4599_RS21105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_RS21180	COG0598	Magnesium transport protein CorA
B4599_RS21190	COG1113	amino acid transport
B4599_RS21200	COG5297	Belongs to the glycosyl hydrolase family 6
B4599_RS21205	COG4305	rare lipoprotein A
B4599_RS21210	COG0697	spore germination
B4599_RS21270	COG4221	oxidoreductase activity
B4599_RS21300	COG0456	acetyltransferase
B4599_RS21310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B4599_RS21345	COG2111	Na H antiporter
B4599_RS21345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4599_RS21350	COG1006	Multisubunit Na H antiporter MnhC subunit
B4599_RS21355	COG0651	ATP synthesis coupled electron transport
B4599_RS21365	COG2212	antiporter activity
B4599_RS21370	COG1320	monovalent cation:proton antiporter activity
B4599_RS21380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B4599_RS21400	COG3104	oligopeptide transport
B4599_RS21405	COG3483	tryptophan 2,3-dioxygenase activity
B4599_RS21415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4599_RS21450	COG0183	Belongs to the thiolase family
B4599_RS21505	COG3039	Transposase
B4599_RS21535	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B4599_RS21540	COG3023	N-Acetylmuramoyl-L-alanine amidase
B4599_RS21550	COG4948	Mandelate Racemase Muconate Lactonizing
B4599_RS21590	COG0531	amino acid
B4599_RS21625	COG4682	membrane
B4599_RS21630	COG2133	pyrroloquinoline quinone binding
B4599_RS21670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4599_RS21675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B4599_RS21685	COG1610	YqeY-like protein
B4599_RS21700	COG1295	ribonuclease BN
B4599_RS21705	COG0358	DNA primase activity
B4599_RS21770	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B4599_RS21785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4599_RS21835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4599_RS21840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4599_RS21845	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B4599_RS21855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4599_RS21860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4599_RS21875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4599_RS21975	COG3039	Transposase
B4599_RS21990	COG3328	transposase activity
B4599_RS22005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4599_RS22005	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4599_RS22015	COG1473	amidohydrolase
B4599_RS22020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_RS22025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_RS22040	COG5383	Protein conserved in bacteria
B4599_RS22080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4599_RS22085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B4599_RS22100	COG0028	Belongs to the TPP enzyme family
B4599_RS22105	COG4191	Histidine kinase
B4599_RS22130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4599_RS22145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4599_RS22150	COG3177	Filamentation induced by cAMP protein fic
B4599_RS22165	COG0596	Alpha beta hydrolase
B4599_RS22170	COG0727	PFAM Uncharacterised protein family (UPF0153)
B4599_RS22175	COG0318	PFAM AMP-dependent synthetase and ligase
B4599_RS22180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4599_RS22240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4599_RS22250	COG0129	dihydroxy-acid dehydratase activity
B4599_RS22280	COG3039	Transposase
B4599_RS22290	COG0408	coproporphyrinogen oxidase activity
B4599_RS22340	COG2201	protein-glutamate methylesterase activity
B4599_RS22390	COG2353	YceI-like domain
B4599_RS22420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4599_RS22435	COG3386	PFAM SMP-30 Gluconolaconase
B4599_RS22480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B4599_RS22495	COG4771	TonB-dependent receptor
B4599_RS22505	COG0459	protein refolding
B4599_RS22530	COG1252	NADH dehydrogenase
B4599_RS22540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4599_RS22545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4599_RS22550	COG3437	response regulator, receiver
B4599_RS22555	COG2177	Part of the ABC transporter FtsEX involved in
B4599_RS22560	COG2884	Cell division ATP-binding protein ftsE
B4599_RS22570	COG3118	belongs to the thioredoxin family
B4599_RS22575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4599_RS22590	COG0729	surface antigen
B4599_RS22595	COG2911	Protein conserved in bacteria
B4599_RS22630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4599_RS22645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4599_RS22705	COG1733	regulation of RNA biosynthetic process
B4599_RS22710	COG0702	epimerase
B4599_RS22745	COG0583	DNA-binding transcription factor activity
B4599_RS22750	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4599_RS22770	COG0745	RESPONSE REGULATOR receiver
B4599_RS22800	COG1902	pentaerythritol trinitrate reductase activity
B4599_RS22805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4599_RS22815	COG2814	Major facilitator Superfamily
B4599_RS22820	COG0583	DNA-binding transcription factor activity
B4599_RS22840	COG0084	hydrolase, TatD family'
B4599_RS22890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4599_RS22910	COG2072	flavoprotein involved in K transport
B4599_RS22960	COG4770	biotin carboxylase activity
B4599_RS22965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4599_RS22970	COG1960	acyl-CoA dehydrogenase activity
B4599_RS23025	COG0523	cobalamin synthesis protein
B4599_RS23035	COG0697	spore germination
B4599_RS23045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B4599_RS23060	COG4771	TonB-dependent receptor
B4599_RS23065	COG0457	Tetratricopeptide repeat
B4599_RS23080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4599_RS23105	COG0519	Catalyzes the synthesis of GMP from XMP
B4599_RS23105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4599_RS23115	COG0805	protein transport
B4599_RS23125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4599_RS23135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B4599_RS23190	COG3661	Belongs to the glycosyl hydrolase 67 family
B4599_RS23200	COG4948	Mandelate Racemase Muconate Lactonizing
B4599_RS23210	COG1472	Belongs to the glycosyl hydrolase 3 family
B4599_RS23215	COG0246	Mannitol dehydrogenase
B4599_RS23240	COG3693	PFAM glycoside hydrolase, family 10
B4599_RS23265	COG2211	Major facilitator Superfamily
B4599_RS23310	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B4599_RS23360	COG1846	Transcriptional regulator
B4599_RS23365	COG1764	response to oxidative stress
B4599_RS23465	COG3549	Plasmid maintenance system killer
B4599_RS23475	COG1074	ATP-dependent DNA helicase activity
B4599_RS23480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B4599_RS23520	COG2032	superoxide dismutase activity
B4599_RS23525	COG2032	superoxide dismutase activity
B4599_RS23530	COG2204	response regulator
B4599_RS23535	COG3852	Histidine kinase
B4599_RS23540	COG0004	ammonium transporteR
B4599_RS23545	COG0347	Belongs to the P(II) protein family
B4599_RS23550	COG0174	glutamine synthetase
B4599_RS23555	COG1968	undecaprenyl-diphosphatase activity
B4599_RS23600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4599_RS23610	COG2062	phosphohistidine phosphatase, SixA
B4599_RS23615	COG0489	protein tyrosine kinase activity
B4599_RS23635	COG1396	sequence-specific DNA binding
B4599_RS23640	COG3550	peptidyl-serine autophosphorylation
B4599_RS23645	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B4599_RS23650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_RS23665	COG1125	glycine betaine transport
B4599_RS23665	COG0517	IMP dehydrogenase activity
B4599_RS23680	COG1119	ATPase activity
B4599_RS23690	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4599_RS23705	COG3039	Transposase
B4599_RS23730	COG0656	L-ascorbic acid biosynthetic process
B4599_RS23735	COG2130	NADP-dependent
B4599_RS23740	COG0667	Aldo Keto reductase
B4599_RS23750	COG1187	pseudouridine synthase activity
B4599_RS23765	COG1643	Atp-dependent helicase
B4599_RS23770	COG4807	Protein conserved in bacteria
B4599_RS23775	COG4948	Mandelate Racemase Muconate Lactonizing
B4599_RS23785	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4599_RS23790	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_RS23810	COG3507	Belongs to the glycosyl hydrolase 43 family
B4599_RS23855	COG3162	membrane
B4599_RS23860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4599_RS23875	COG0708	Exodeoxyribonuclease III
B4599_RS23890	COG2091	lysine biosynthetic process via aminoadipic acid
B4599_RS23900	COG3540	Alkaline phosphatase
B4599_RS23930	COG2159	amidohydrolase
B4599_RS23955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B4599_RS23960	COG0583	DNA-binding transcription factor activity
B4599_RS23965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4599_RS23985	COG0210	DNA helicase
B4599_RS24000	COG0531	amino acid
B4599_RS24010	COG1322	Protein conserved in bacteria
B4599_RS24020	COG0386	Belongs to the glutathione peroxidase family
B4599_RS24075	COG0793	Belongs to the peptidase S41A family
B4599_RS24080	COG4942	peptidase
B4599_RS24090	COG2234	aminopeptidase activity
B4599_RS24140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4599_RS24145	COG0302	gtp cyclohydrolase
B4599_RS24170	COG0477	Major facilitator Superfamily
B4599_RS24275	COG1929	Belongs to the glycerate kinase type-1 family
B4599_RS24280	COG2271	Major facilitator Superfamily
B4599_RS24295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4599_RS24305	COG0861	Integral membrane protein TerC family
B4599_RS24315	COG0584	glycerophosphoryl diester phosphodiesterase
B4599_RS24325	COG0671	phosphoesterase, PA-phosphatase related
B4599_RS24335	COG0726	polysaccharide deacetylase