locus-tag	class	description
BRN66_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRN66_RS00030	COG0187	DNA topoisomerase II activity
BRN66_RS00040	COG0501	Belongs to the peptidase M48B family
BRN66_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN66_RS00090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRN66_RS00100	COG4772	TonB-dependent receptor
BRN66_RS00115	COG3039	Transposase
BRN66_RS00120	COG1304	FMN binding
BRN66_RS00125	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRN66_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN66_RS00160	COG3039	Transposase
BRN66_RS00165	COG1136	(ABC) transporter
BRN66_RS00215	COG3039	Transposase
BRN66_RS00225	COG0513	Belongs to the DEAD box helicase family
BRN66_RS00330	COG1858	cytochrome C peroxidase
BRN66_RS00340	COG0702	epimerase
BRN66_RS00365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRN66_RS00385	COG1649	PFAM Uncharacterised BCR, COG1649
BRN66_RS00390	COG2354	Protein conserved in bacteria
BRN66_RS00400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRN66_RS00415	COG1511	domain protein
BRN66_RS00415	COG3264	Mechanosensitive ion channel
BRN66_RS00495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN66_RS00575	COG3039	Transposase
BRN66_RS00585	COG3039	Transposase
BRN66_RS00620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN66_RS00630	COG0642	Histidine kinase
BRN66_RS00640	COG1090	epimerase
BRN66_RS00650	COG3039	Transposase
BRN66_RS00675	COG2826	transposase and inactivated derivatives, IS30 family
BRN66_RS00740	COG1136	(ABC) transporter
BRN66_RS00785	COG1272	protein, Hemolysin III
BRN66_RS00790	COG1111	helicase
BRN66_RS00790	COG1205	dead DEAH box helicase
BRN66_RS00850	COG0067	glutamate synthase
BRN66_RS00850	COG0069	glutamate synthase activity
BRN66_RS00850	COG0070	glutamate synthase
BRN66_RS00855	COG0493	'glutamate synthase
BRN66_RS00905	COG1609	Transcriptional regulator
BRN66_RS00940	COG0366	Alpha amylase catalytic
BRN66_RS00945	COG0366	Alpha amylase catalytic
BRN66_RS01000	COG0606	chelatase, subunit chli
BRN66_RS01045	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRN66_RS01050	COG1166	arginine decarboxylase activity
BRN66_RS01115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRN66_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS01165	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRN66_RS01180	COG0210	DNA helicase
BRN66_RS01195	COG3132	Protein of unknown function, DUF480
BRN66_RS01200	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRN66_RS01205	COG0284	orotidine-5'-phosphate decarboxylase activity
BRN66_RS01240	COG2937	Belongs to the GPAT DAPAT family
BRN66_RS01270	COG2755	lipolytic protein G-D-S-L family
BRN66_RS01285	COG3186	Phenylalanine-4-hydroxylase
BRN66_RS01290	COG1522	sequence-specific DNA binding
BRN66_RS01340	COG1064	alcohol dehydrogenase
BRN66_RS01350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_RS01360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_RS01370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_RS01395	COG3039	Transposase
BRN66_RS01400	COG0676	glucose-6-phosphate 1-epimerase activity
BRN66_RS01465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BRN66_RS01490	COG2853	Lipoprotein
BRN66_RS01505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN66_RS01510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN66_RS01515	COG1127	ABC transporter
BRN66_RS01590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_RS01605	COG3265	gluconokinase activity
BRN66_RS01610	COG2211	Major facilitator Superfamily
BRN66_RS01615	COG3459	Glycosyltransferase 36 associated
BRN66_RS01630	COG2205	protein histidine kinase activity
BRN66_RS01640	COG1414	Transcriptional regulator
BRN66_RS01645	COG0738	Major facilitator superfamily
BRN66_RS01650	COG3254	rhamnose metabolic process
BRN66_RS01680	COG0339	signal peptide processing
BRN66_RS01710	COG0564	pseudouridine synthase activity
BRN66_RS01720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRN66_RS01820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRN66_RS01830	COG0842	Transport permease protein
BRN66_RS01835	COG1131	(ABC) transporter
BRN66_RS01840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN66_RS01860	COG1476	TRANSCRIPTIONal
BRN66_RS01870	COG4555	ABC transporter
BRN66_RS01910	COG0625	glutathione transferase activity
BRN66_RS01960	COG0583	DNA-binding transcription factor activity
BRN66_RS01995	COG1199	ATP-dependent helicase activity
BRN66_RS02015	COG1566	PFAM secretion protein HlyD family protein
BRN66_RS02045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN66_RS02085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRN66_RS02085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRN66_RS02090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRN66_RS02105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRN66_RS02145	COG3237	CsbD-like
BRN66_RS02150	COG0180	Tryptophanyl-tRNA synthetase
BRN66_RS02155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN66_RS02205	COG0753	catalase activity
BRN66_RS02210	COG1595	DNA-templated transcription, initiation
BRN66_RS02220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRN66_RS02230	COG0628	permease
BRN66_RS02245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRN66_RS02250	COG1040	competence protein
BRN66_RS02255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRN66_RS02260	COG0156	8-amino-7-oxononanoate synthase activity
BRN66_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS02290	COG0463	Glycosyl transferase, family 2
BRN66_RS02300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRN66_RS02305	COG3100	YcgL domain-containing protein
BRN66_RS02325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN66_RS02345	COG2239	Acts as a magnesium transporter
BRN66_RS02355	COG1042	CoA-binding domain protein
BRN66_RS02355	COG0045	succinate-CoA ligase (ADP-forming) activity
BRN66_RS02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRN66_RS02365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN66_RS02375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN66_RS02410	COG3485	protocatechuate 3,4-dioxygenase
BRN66_RS02415	COG3485	protocatechuate 3,4-dioxygenase
BRN66_RS02430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN66_RS02435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRN66_RS02465	COG4221	oxidoreductase activity
BRN66_RS02485	COG2003	Belongs to the UPF0758 family
BRN66_RS02490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRN66_RS02515	COG0463	Glycosyl transferase, family 2
BRN66_RS02530	COG1475	DNA binding
BRN66_RS02535	COG1192	Involved in chromosome partitioning
BRN66_RS02550	COG0708	Exodeoxyribonuclease III
BRN66_RS02555	COG2211	Major facilitator Superfamily
BRN66_RS02570	COG0739	heme binding
BRN66_RS02620	COG0745	RESPONSE REGULATOR receiver
BRN66_RS02660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRN66_RS02685	COG2814	Major facilitator Superfamily
BRN66_RS02700	COG1289	transmembrane transporter activity
BRN66_RS02710	COG1136	(ABC) transporter
BRN66_RS02710	COG0577	efflux transmembrane transporter activity
BRN66_RS02715	COG0151	Belongs to the GarS family
BRN66_RS02725	COG0419	ATPase involved in DNA repair
BRN66_RS02740	COG2267	carboxylic ester hydrolase activity
BRN66_RS02750	COG2267	carboxylic ester hydrolase activity
BRN66_RS02755	COG2453	phosphatase
BRN66_RS02755	COG0671	phosphoesterase, PA-phosphatase related
BRN66_RS02770	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRN66_RS02830	COG0439	Biotin carboxylase
BRN66_RS02840	COG0511	ligase activity, forming carbon-carbon bonds
BRN66_RS02845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRN66_RS02865	COG1324	tolerance protein
BRN66_RS02900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRN66_RS02930	COG0534	Mate efflux family protein
BRN66_RS02935	COG0616	signal peptide processing
BRN66_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS02960	COG0009	L-threonylcarbamoyladenylate synthase
BRN66_RS02965	COG1754	DNA topoisomerase type I activity
BRN66_RS02965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRN66_RS02980	COG2922	Belongs to the Smg family
BRN66_RS02985	COG0758	DNA mediated transformation
BRN66_RS02990	COG1652	LysM domain
BRN66_RS02995	COG0242	peptide deformylase activity
BRN66_RS03000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRN66_RS03005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRN66_RS03005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRN66_RS03055	COG1560	Kdo2-lipid A biosynthetic process
BRN66_RS03065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN66_RS03220	COG1294	oxidase, subunit
BRN66_RS03225	COG1271	oxidase subunit
BRN66_RS03240	COG2204	response regulator
BRN66_RS03270	COG2972	Histidine kinase
BRN66_RS03285	COG0531	amino acid
BRN66_RS03305	COG3590	peptidase
BRN66_RS03320	COG0667	Aldo Keto reductase
BRN66_RS03335	COG3384	dioxygenase
BRN66_RS03345	COG1573	uracil-dna glycosylase
BRN66_RS03355	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRN66_RS03370	COG0025	NhaP-type Na H and K H
BRN66_RS03375	COG1131	(ABC) transporter
BRN66_RS03380	COG0842	Transport permease protein
BRN66_RS03395	COG1404	Belongs to the peptidase S8 family
BRN66_RS03410	COG0745	RESPONSE REGULATOR receiver
BRN66_RS03460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_RS03485	COG2202	Pas domain
BRN66_RS03485	COG2205	protein histidine kinase activity
BRN66_RS03520	COG2813	Specifically methylates the guanine in position
BRN66_RS03525	COG1187	pseudouridine synthase activity
BRN66_RS03530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRN66_RS03565	COG0697	spore germination
BRN66_RS03575	COG2011	ABC-type metal ion transport system permease component
BRN66_RS03605	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRN66_RS03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRN66_RS03635	COG0356	it plays a direct role in the translocation of protons across the membrane
BRN66_RS03645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRN66_RS03655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRN66_RS03660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRN66_RS03665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRN66_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_RS03730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN66_RS03785	COG0339	signal peptide processing
BRN66_RS03825	COG1956	GAF domain-containing protein
BRN66_RS03830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRN66_RS03840	COG0720	synthase
BRN66_RS03850	COG0513	Belongs to the DEAD box helicase family
BRN66_RS03895	COG0626	cystathionine gamma-synthase activity
BRN66_RS03945	COG3328	transposase activity
BRN66_RS03970	COG2086	electron transfer activity
BRN66_RS03995	COG0662	Cupin 2, conserved barrel domain protein
BRN66_RS03995	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRN66_RS04000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRN66_RS04040	COG3218	ABC-type transport auxiliary lipoprotein component
BRN66_RS04040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN66_RS04045	COG1127	ABC transporter
BRN66_RS04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN66_RS04065	COG0442	prolyl-tRNA aminoacylation
BRN66_RS04075	COG1183	phosphatidylcholine synthase activity
BRN66_RS04105	COG3039	Transposase
BRN66_RS04175	COG0525	valine-tRNA ligase activity
BRN66_RS04190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRN66_RS04200	COG0795	lipopolysaccharide-transporting ATPase activity
BRN66_RS04215	COG4974	Belongs to the 'phage' integrase family
BRN66_RS04220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRN66_RS04225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRN66_RS04225	COG0047	phosphoribosylformylglycinamidine synthase activity
BRN66_RS04235	COG5295	Hep Hag repeat protein
BRN66_RS04255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN66_RS04265	COG1459	type II secretion system
BRN66_RS04270	COG2165	general secretion pathway protein
BRN66_RS04275	COG4970	Tfp pilus assembly protein FimT
BRN66_RS04280	COG2165	general secretion pathway protein
BRN66_RS04285	COG4795	General secretion pathway protein
BRN66_RS04290	COG3156	type II secretion system protein K
BRN66_RS04295	COG3166	PFAM Fimbrial assembly family protein
BRN66_RS04310	COG1450	Type ii and iii secretion system protein
BRN66_RS04325	COG2188	Transcriptional regulator
BRN66_RS04380	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRN66_RS04385	COG1518	maintenance of DNA repeat elements
BRN66_RS04430	COG1399	metal-binding, possibly nucleic acid-binding protein
BRN66_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS04460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRN66_RS04470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRN66_RS04475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRN66_RS04510	COG3829	transcription factor binding
BRN66_RS04545	COG3039	Transposase
BRN66_RS04605	COG2826	transposase and inactivated derivatives, IS30 family
BRN66_RS04615	COG0678	peroxiredoxin activity
BRN66_RS04635	COG0330	HflC and HflK could
BRN66_RS04640	COG0330	HflC and HflK could
BRN66_RS04655	COG0308	aminopeptidase N
BRN66_RS04705	COG1560	Kdo2-lipid A biosynthetic process
BRN66_RS04710	COG1519	Transferase
BRN66_RS04715	COG1538	Outer membrane efflux protein
BRN66_RS04720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRN66_RS04745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRN66_RS04750	COG0066	3-isopropylmalate dehydratase activity
BRN66_RS04785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRN66_RS04795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRN66_RS04800	COG3710	Transcriptional regulator
BRN66_RS04825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRN66_RS04845	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRN66_RS04875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRN66_RS04885	COG3781	membrane
BRN66_RS04905	COG0625	glutathione transferase activity
BRN66_RS04915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRN66_RS04920	COG1217	gtp-binding protein TYPA
BRN66_RS04940	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRN66_RS05075	COG3039	Transposase
BRN66_RS05100	COG0584	glycerophosphoryl diester phosphodiesterase
BRN66_RS05125	COG0473	3-isopropylmalate dehydrogenase activity
BRN66_RS05220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRN66_RS05245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN66_RS05255	COG0631	protein serine/threonine phosphatase activity
BRN66_RS05340	COG0582	viral genome integration into host DNA
BRN66_RS05350	COG0859	PFAM glycosyl transferase family 9
BRN66_RS05355	COG3642	lipopolysaccharide core region biosynthetic process
BRN66_RS05360	COG1234	tRNA 3'-trailer cleavage
BRN66_RS05365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRN66_RS05375	COG0315	cyclic pyranopterin monophosphate synthase activity
BRN66_RS05380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRN66_RS05385	COG0314	molybdopterin synthase activity
BRN66_RS05415	COG0537	adenosine 5'-monophosphoramidase activity
BRN66_RS05435	COG0714	Associated with various cellular activities
BRN66_RS05455	COG0242	peptide deformylase activity
BRN66_RS05505	COG3039	Transposase
BRN66_RS05535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN66_RS05540	COG0726	polysaccharide deacetylase
BRN66_RS05590	COG2211	Major facilitator Superfamily
BRN66_RS05600	COG1609	Transcriptional regulator
BRN66_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS05610	COG2851	Citrate transporter
BRN66_RS05630	COG0642	Histidine kinase
BRN66_RS05640	COG2197	response regulator
BRN66_RS05660	COG0583	DNA-binding transcription factor activity
BRN66_RS05675	COG4191	Histidine kinase
BRN66_RS05695	COG0280	phosphate acetyltransferase
BRN66_RS05695	COG0281	malic enzyme
BRN66_RS05730	COG0352	thiamine-phosphate diphosphorylase activity
BRN66_RS05735	COG1773	rubredoxin
BRN66_RS05740	COG2912	Transglutaminase-like superfamily
BRN66_RS05760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRN66_RS05785	COG0006	proline dipeptidase activity
BRN66_RS05820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRN66_RS05835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BRN66_RS05840	COG1561	YicC-like family, N-terminal region
BRN66_RS05865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN66_RS05875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRN66_RS05900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRN66_RS05950	COG0714	Associated with various cellular activities
BRN66_RS05970	COG2304	oxidoreductase activity
BRN66_RS05990	COG1301	dicarboxylic acid transport
BRN66_RS05995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRN66_RS06005	COG0739	heme binding
BRN66_RS06010	COG1376	ErfK ybiS ycfS ynhG family protein
BRN66_RS06035	COG1022	Amp-dependent synthetase and ligase
BRN66_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS06060	COG0642	Histidine kinase
BRN66_RS06080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRN66_RS06085	COG4149	molybdate abc transporter
BRN66_RS06090	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRN66_RS06095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN66_RS06095	COG3453	Protein conserved in bacteria
BRN66_RS06130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRN66_RS06150	COG2205	protein histidine kinase activity
BRN66_RS06155	COG0745	RESPONSE REGULATOR receiver
BRN66_RS06205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRN66_RS06210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRN66_RS06320	COG2201	protein-glutamate methylesterase activity
BRN66_RS06370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRN66_RS06385	COG1842	Phage shock protein A
BRN66_RS06410	COG0754	glutathionylspermidine amidase activity
BRN66_RS06480	COG0531	amino acid
BRN66_RS06485	COG2197	response regulator
BRN66_RS06500	COG1113	amino acid transport
BRN66_RS06520	COG1271	oxidase subunit
BRN66_RS06525	COG1294	oxidase, subunit
BRN66_RS06535	COG2239	Acts as a magnesium transporter
BRN66_RS06545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN66_RS06550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN66_RS06560	COG1660	Displays ATPase and GTPase activities
BRN66_RS06565	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRN66_RS06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN66_RS06585	COG1137	ATPase activity
BRN66_RS06590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRN66_RS06600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRN66_RS06610	COG0271	Belongs to the BolA IbaG family
BRN66_RS06620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRN66_RS06640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRN66_RS06655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRN66_RS06665	COG0628	permease
BRN66_RS06675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRN66_RS06680	COG3178	'Phosphotransferase
BRN66_RS06695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN66_RS06700	COG1555	photosystem II stabilization
BRN66_RS06745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN66_RS06755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRN66_RS06780	COG0228	four-way junction DNA binding
BRN66_RS06785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRN66_RS06790	COG0336	Belongs to the RNA methyltransferase TrmD family
BRN66_RS06805	COG0534	Mate efflux family protein
BRN66_RS06845	COG0542	response to heat
BRN66_RS06885	COG4206	TonB-dependent receptor
BRN66_RS06945	COG0019	diaminopimelate decarboxylase activity
BRN66_RS06955	COG2814	Major facilitator Superfamily
BRN66_RS06960	COG4264	IucA IucC family
BRN66_RS06970	COG4772	TonB-dependent receptor
BRN66_RS06985	COG4651	solute:proton antiporter activity
BRN66_RS06985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRN66_RS07020	COG0488	(ABC) transporter
BRN66_RS07045	COG2755	lipolytic protein G-D-S-L family
BRN66_RS07045	COG0657	acetylesterase activity
BRN66_RS07065	COG2207	Transcriptional regulator
BRN66_RS07100	COG3328	transposase activity
BRN66_RS07105	COG0174	glutamine synthetase
BRN66_RS07110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRN66_RS07120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRN66_RS07135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRN66_RS07165	COG2146	nitrite reductase [NAD(P)H] activity
BRN66_RS07175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRN66_RS07180	COG0719	Fe-S assembly protein
BRN66_RS07185	COG0396	ATPase activity
BRN66_RS07190	COG0719	Fe-S assembly protein
BRN66_RS07195	COG1959	2 iron, 2 sulfur cluster binding
BRN66_RS07215	COG0693	protein deglycase activity
BRN66_RS07260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRN66_RS07295	COG0519	Catalyzes the synthesis of GMP from XMP
BRN66_RS07305	COG1678	Uncharacterized ACR, COG1678
BRN66_RS07310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRN66_RS07325	COG1764	response to oxidative stress
BRN66_RS07335	COG0384	phenazine biosynthesis protein PhzF
BRN66_RS07345	COG0527	aspartate kinase activity
BRN66_RS07375	COG0142	geranyltranstransferase activity
BRN66_RS07380	COG0629	single-stranded DNA binding
BRN66_RS07385	COG5001	Diguanylate cyclase
BRN66_RS07385	COG4251	negative regulation of phosphorylation
BRN66_RS07385	COG3706	GGDEF domain
BRN66_RS07385	COG2203	Gaf domain
BRN66_RS07420	COG2879	small protein
BRN66_RS07425	COG1966	Carbon starvation protein
BRN66_RS07430	COG1741	Belongs to the pirin family
BRN66_RS07545	COG1741	Belongs to the pirin family
BRN66_RS07555	COG1515	deoxyribonuclease V activity
BRN66_RS07580	COG3590	peptidase
BRN66_RS07595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRN66_RS07600	COG2200	EAL domain
BRN66_RS07600	COG2199	diguanylate cyclase activity
BRN66_RS07600	COG2202	Pas domain
BRN66_RS07605	COG0835	chemotaxis
BRN66_RS07610	COG0840	transmembrane signaling receptor activity
BRN66_RS07615	COG2198	Histidine kinase
BRN66_RS07615	COG0643	Histidine kinase
BRN66_RS07625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRN66_RS07635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRN66_RS07655	COG2205	protein histidine kinase activity
BRN66_RS07680	COG3039	Transposase
BRN66_RS07705	COG3039	Transposase
BRN66_RS07740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRN66_RS07745	COG0735	belongs to the Fur family
BRN66_RS07805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRN66_RS07810	COG0084	hydrolase, TatD family'
BRN66_RS07825	COG1960	acyl-CoA dehydrogenase activity
BRN66_RS07840	COG0367	asparagine synthase
BRN66_RS07850	COG0305	Participates in initiation and elongation during chromosome replication
BRN66_RS07855	COG0415	Belongs to the DNA photolyase family
BRN66_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS07920	COG3039	Transposase
BRN66_RS07980	COG5002	protein histidine kinase activity
BRN66_RS07980	COG5001	Diguanylate cyclase
BRN66_RS07985	COG1187	pseudouridine synthase activity
BRN66_RS08010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRN66_RS08020	COG0475	glutathione-regulated potassium exporter activity
BRN66_RS08025	COG5002	protein histidine kinase activity
BRN66_RS08025	COG5000	phosphorelay sensor kinase activity
BRN66_RS08030	COG0745	RESPONSE REGULATOR receiver
BRN66_RS08060	COG1132	(ABC) transporter
BRN66_RS08085	COG3039	Transposase
BRN66_RS08100	COG3039	Transposase
BRN66_RS08145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRN66_RS08155	COG4969	Belongs to the N-Me-Phe pilin family
BRN66_RS08160	COG2194	sulfuric ester hydrolase activity
BRN66_RS08200	COG0045	succinate-CoA ligase (ADP-forming) activity
BRN66_RS08205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRN66_RS08220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRN66_RS08220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN66_RS08225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_RS08230	COG0564	pseudouridine synthase activity
BRN66_RS08255	COG3387	PFAM Glycoside hydrolase 15-related
BRN66_RS08260	COG1877	trehalose-phosphatase activity
BRN66_RS08300	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BRN66_RS08320	COG1595	DNA-templated transcription, initiation
BRN66_RS08330	COG1946	Acyl-CoA thioesterase
BRN66_RS08345	COG0824	Thioesterase
BRN66_RS08350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRN66_RS08360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRN66_RS08365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRN66_RS08370	COG0268	Binds directly to 16S ribosomal RNA
BRN66_RS08375	COG0728	peptidoglycan biosynthetic process
BRN66_RS08380	COG0196	riboflavin kinase activity
BRN66_RS08390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRN66_RS08395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRN66_RS08410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRN66_RS08415	COG1845	cytochrome c oxidase, subunit III
BRN66_RS08420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRN66_RS08440	COG3209	COG3209 Rhs family protein
BRN66_RS08440	COG3209	COG3209 Rhs family protein
BRN66_RS08560	COG0632	four-way junction helicase activity
BRN66_RS08570	COG2255	four-way junction helicase activity
BRN66_RS08575	COG0824	Thioesterase
BRN66_RS08585	COG0848	biopolymer transport protein
BRN66_RS08600	COG2885	chlorophyll binding
BRN66_RS08610	COG0602	queuosine metabolic process
BRN66_RS08620	COG1187	pseudouridine synthase activity
BRN66_RS08680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRN66_RS08705	COG0514	ATP-dependent DNA helicase (RecQ)
BRN66_RS08715	COG0783	Belongs to the Dps family
BRN66_RS08720	COG1643	Atp-dependent helicase
BRN66_RS08775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN66_RS08785	COG1215	transferase activity, transferring glycosyl groups
BRN66_RS08790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRN66_RS08800	COG1199	ATP-dependent helicase activity
BRN66_RS08810	COG1397	ADP-ribosylglycohydrolase
BRN66_RS08820	COG0189	ligase activity
BRN66_RS08835	COG0835	chemotaxis
BRN66_RS08840	COG0840	transmembrane signaling receptor activity
BRN66_RS08845	COG0643	Histidine kinase
BRN66_RS08845	COG2198	Histidine kinase
BRN66_RS08845	COG0784	Response regulator, receiver
BRN66_RS08890	COG1446	asparaginase
BRN66_RS08895	COG3142	Participates in the control of copper homeostasis
BRN66_RS08950	COG3537	Alpha-1,2-mannosidase
BRN66_RS09020	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN66_RS09040	COG1388	LysM domain
BRN66_RS09040	COG3858	chitin binding
BRN66_RS09055	COG0837	glucose binding
BRN66_RS09060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRN66_RS09070	COG0494	nUDIX hydrolase
BRN66_RS09080	COG3956	TIGRFAM MazG family protein
BRN66_RS09095	COG0330	HflC and HflK could
BRN66_RS09110	COG0509	glycine decarboxylation via glycine cleavage system
BRN66_RS09145	COG1960	acyl-CoA dehydrogenase activity
BRN66_RS09155	COG1309	transcriptional regulator
BRN66_RS09160	COG4771	TonB-dependent receptor
BRN66_RS09170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRN66_RS09180	COG0463	Glycosyl transferase, family 2
BRN66_RS09200	COG1272	protein, Hemolysin III
BRN66_RS09210	COG0739	heme binding
BRN66_RS09215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN66_RS09220	COG0626	cystathionine gamma-synthase activity
BRN66_RS09230	COG1760	l-serine dehydratase
BRN66_RS09245	COG2353	YceI-like domain
BRN66_RS09255	COG2353	YceI-like domain
BRN66_RS09305	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BRN66_RS09325	COG1960	acyl-CoA dehydrogenase activity
BRN66_RS09330	COG1024	Enoyl-CoA hydratase
BRN66_RS09350	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN66_RS09350	COG1024	Enoyl-CoA hydratase
BRN66_RS09365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN66_RS09395	COG1381	Involved in DNA repair and RecF pathway recombination
BRN66_RS09410	COG2954	triphosphatase activity
BRN66_RS09425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRN66_RS09430	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRN66_RS09435	COG3046	protein related to deoxyribodipyrimidine photolyase
BRN66_RS09445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BRN66_RS09450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRN66_RS09455	COG1278	Cold shock
BRN66_RS09475	COG1201	RNA secondary structure unwinding
BRN66_RS09480	COG1793	dna ligase
BRN66_RS09490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRN66_RS09490	COG1793	dna ligase
BRN66_RS09520	COG0183	Belongs to the thiolase family
BRN66_RS09545	COG1451	nucleotide metabolic process
BRN66_RS09560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN66_RS09605	COG1047	Peptidyl-prolyl cis-trans
BRN66_RS09620	COG2824	Alkylphosphonate utilization operon protein PhnA
BRN66_RS09635	COG1902	pentaerythritol trinitrate reductase activity
BRN66_RS09640	COG2814	Major facilitator Superfamily
BRN66_RS09695	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRN66_RS09695	COG0392	lysyltransferase activity
BRN66_RS09705	COG0251	oxidation-reduction process
BRN66_RS09710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN66_RS09725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN66_RS09750	COG1595	DNA-templated transcription, initiation
BRN66_RS09770	COG2878	Part of a membrane complex involved in electron transport
BRN66_RS09780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRN66_RS09780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRN66_RS09800	COG0833	amino acid
BRN66_RS09805	COG2040	homocysteine
BRN66_RS09820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN66_RS09855	COG2895	sulfate adenylyltransferase (ATP) activity
BRN66_RS09855	COG0529	Catalyzes the synthesis of activated sulfate
BRN66_RS09900	COG1981	membrane
BRN66_RS09925	COG1131	(ABC) transporter
BRN66_RS09930	COG4771	TonB-dependent receptor
BRN66_RS09940	COG0825	malonyl-CoA metabolic process
BRN66_RS09960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRN66_RS09965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRN66_RS09985	COG0750	zinc metalloprotease
BRN66_RS09995	COG0575	Belongs to the CDS family
BRN66_RS10005	COG0233	cytoplasmic translational termination
BRN66_RS10020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRN66_RS10080	COG1393	Belongs to the ArsC family
BRN66_RS10095	COG0367	asparagine synthase
BRN66_RS10110	COG4774	siderophore transport
BRN66_RS10150	COG1566	PFAM secretion protein HlyD family protein
BRN66_RS10155	COG2814	Major facilitator Superfamily
BRN66_RS10200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRN66_RS10210	COG1960	acyl-CoA dehydrogenase activity
BRN66_RS10235	COG2914	Belongs to the UPF0125 (RnfH) family
BRN66_RS10245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_RS10255	COG0497	DNA recombination
BRN66_RS10265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRN66_RS10270	COG0443	Heat shock 70 kDa protein
BRN66_RS10275	COG0484	heat shock protein binding
BRN66_RS10285	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRN66_RS10290	COG1605	Chorismate mutase
BRN66_RS10290	COG0287	Prephenate dehydrogenase
BRN66_RS10310	COG0583	DNA-binding transcription factor activity
BRN66_RS10325	COG1132	(ABC) transporter
BRN66_RS10360	COG2850	peptidyl-arginine hydroxylation
BRN66_RS10440	COG1131	(ABC) transporter
BRN66_RS10445	COG1725	Transcriptional regulator
BRN66_RS10455	COG0386	Belongs to the glutathione peroxidase family
BRN66_RS10470	COG2900	Belongs to the SlyX family
BRN66_RS10485	COG1609	Transcriptional regulator
BRN66_RS10495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN66_RS10505	COG0646	methionine synthase
BRN66_RS10505	COG1410	methionine synthase
BRN66_RS10510	COG0646	methionine synthase
BRN66_RS10510	COG1410	methionine synthase
BRN66_RS10515	COG2226	methyltransferase
BRN66_RS10520	COG1960	acyl-CoA dehydrogenase activity
BRN66_RS10550	COG0557	exoribonuclease II activity
BRN66_RS10570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN66_RS10585	COG3039	Transposase
BRN66_RS10610	COG3328	transposase activity
BRN66_RS10620	COG1278	Cold shock
BRN66_RS10635	COG3039	Transposase
BRN66_RS10640	COG3039	Transposase
BRN66_RS10690	COG3039	Transposase
BRN66_RS10700	COG0583	DNA-binding transcription factor activity
BRN66_RS10760	COG2201	protein-glutamate methylesterase activity
BRN66_RS10795	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BRN66_RS10805	COG0531	amino acid
BRN66_RS10810	COG0531	amino acid
BRN66_RS10820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRN66_RS10825	COG0277	FAD linked oxidase domain protein
BRN66_RS10890	COG0436	Aminotransferase
BRN66_RS10915	COG1187	pseudouridine synthase activity
BRN66_RS10920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRN66_RS10925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRN66_RS10930	COG2350	Protein conserved in bacteria
BRN66_RS10960	COG1175	transmembrane transport
BRN66_RS10965	COG0395	ABC-type sugar transport system, permease component
BRN66_RS10990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN66_RS11000	COG2957	Belongs to the agmatine deiminase family
BRN66_RS11015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRN66_RS11020	COG0539	negative regulation of cytoplasmic translation
BRN66_RS11025	COG0776	regulation of translation
BRN66_RS11035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRN66_RS11040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN66_RS11050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRN66_RS11070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRN66_RS11085	COG3002	Belongs to the UPF0753 family
BRN66_RS11090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN66_RS11095	COG0583	DNA-binding transcription factor activity
BRN66_RS11125	COG0583	DNA-binding transcription factor activity
BRN66_RS11150	COG1914	H( )-stimulated, divalent metal cation uptake system
BRN66_RS11170	COG0668	transmembrane transport
BRN66_RS11210	COG3039	Transposase
BRN66_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS11235	COG1183	phosphatidylcholine synthase activity
BRN66_RS11245	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRN66_RS11260	COG0723	plastoquinol--plastocyanin reductase activity
BRN66_RS11260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_RS11270	COG2183	response to ionizing radiation
BRN66_RS11285	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRN66_RS11300	COG0671	phosphoesterase, PA-phosphatase related
BRN66_RS11325	COG1794	racemase activity, acting on amino acids and derivatives
BRN66_RS11335	COG0697	spore germination
BRN66_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
BRN66_RS11395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRN66_RS11410	COG0124	histidyl-tRNA synthetase
BRN66_RS11430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRN66_RS11455	COG2801	Transposase and inactivated derivatives
BRN66_RS11470	COG3039	Transposase
BRN66_RS11495	COG3328	transposase activity
BRN66_RS11530	COG0322	excinuclease ABC activity
BRN66_RS11540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRN66_RS11550	COG1663	tetraacyldisaccharide 4'-kinase activity
BRN66_RS11565	COG0811	peptide transport
BRN66_RS11595	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRN66_RS11610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRN66_RS11625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRN66_RS11640	COG0354	folic acid binding
BRN66_RS11655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN66_RS11665	COG0363	glucosamine-6-phosphate deaminase activity
BRN66_RS11670	COG0129	dihydroxy-acid dehydratase activity
BRN66_RS11675	COG0800	Aldolase
BRN66_RS11705	COG5002	protein histidine kinase activity
BRN66_RS11705	COG2205	protein histidine kinase activity
BRN66_RS11705	COG0784	Response regulator, receiver
BRN66_RS11790	COG0386	Belongs to the glutathione peroxidase family
BRN66_RS11880	COG5001	Diguanylate cyclase
BRN66_RS11880	COG4251	negative regulation of phosphorylation
BRN66_RS11880	COG3706	GGDEF domain
BRN66_RS11880	COG2203	Gaf domain
BRN66_RS11900	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN66_RS11950	COG0617	tRNA 3'-terminal CCA addition
BRN66_RS11960	COG1469	GTP cyclohydrolase I activity
BRN66_RS11965	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN66_RS12015	COG4566	intracellular signal transduction
BRN66_RS12055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRN66_RS12060	COG0077	Prephenate dehydratase
BRN66_RS12060	COG1605	Chorismate mutase
BRN66_RS12070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRN66_RS12115	COG1228	amidohydrolase
BRN66_RS12120	COG2986	histidine ammonia-lyase
BRN66_RS12130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRN66_RS12155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRN66_RS12170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRN66_RS12185	COG3115	cell septum assembly
BRN66_RS12195	COG0359	binds to the 23S rRNA
BRN66_RS12205	COG0360	Binds together with S18 to 16S ribosomal RNA
BRN66_RS12210	COG0316	Belongs to the HesB IscA family
BRN66_RS12245	COG0288	reversible hydration of carbon dioxide
BRN66_RS12270	COG2925	Exonuclease
BRN66_RS12280	COG0667	Aldo Keto reductase
BRN66_RS12305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRN66_RS12305	COG0116	Belongs to the methyltransferase superfamily
BRN66_RS12350	COG0494	nUDIX hydrolase
BRN66_RS12360	COG1024	Enoyl-CoA hydratase
BRN66_RS12370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRN66_RS12385	COG3039	Transposase
BRN66_RS12425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRN66_RS12430	COG0573	inorganic phosphate transmembrane transporter activity
BRN66_RS12445	COG0704	Plays a role in the regulation of phosphate uptake
BRN66_RS12455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN66_RS12470	COG3328	transposase activity
BRN66_RS12505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRN66_RS12510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRN66_RS12515	COG1862	Preprotein translocase
BRN66_RS12520	COG0343	queuine tRNA-ribosyltransferase activity
BRN66_RS12605	COG0405	Gamma-glutamyltransferase
BRN66_RS12610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRN66_RS12625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRN66_RS12630	COG0742	ribosomal rna small subunit methyltransferase
BRN66_RS12650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRN66_RS12680	COG3039	Transposase
BRN66_RS12690	COG3039	Transposase
BRN66_RS12720	COG0303	'Molybdopterin
BRN66_RS12730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_RS12740	COG1426	Protein conserved in bacteria
BRN66_RS12750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRN66_RS12765	COG1024	Enoyl-CoA hydratase
BRN66_RS12765	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN66_RS12770	COG0183	Belongs to the thiolase family
BRN66_RS12775	COG0038	chloride channel
BRN66_RS12795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRN66_RS12820	COG1674	ftsk spoiiie
BRN66_RS12825	COG0492	ferredoxin-NADP+ reductase activity
BRN66_RS12850	COG0542	response to heat
BRN66_RS12865	COG0482	sulfurtransferase activity
BRN66_RS12890	COG5001	Diguanylate cyclase
BRN66_RS12895	COG4585	Histidine kinase
BRN66_RS12905	COG5002	protein histidine kinase activity
BRN66_RS12925	COG0784	Response regulator, receiver
BRN66_RS12925	COG0835	chemotaxis
BRN66_RS12935	COG1558	bacterial-type flagellum-dependent cell motility
BRN66_RS12940	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRN66_RS12950	COG4787	bacterial-type flagellum-dependent cell motility
BRN66_RS12990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRN66_RS12995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRN66_RS13025	COG2201	protein-glutamate methylesterase activity
BRN66_RS13045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN66_RS13055	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS13090	COG1677	Flagellar hook-basal body complex protein FliE
BRN66_RS13140	COG3190	flagellar
BRN66_RS13160	COG1684	flagellar biosynthetic protein fliR
BRN66_RS13215	COG0784	Response regulator, receiver
BRN66_RS13215	COG2198	Histidine kinase
BRN66_RS13215	COG0643	Histidine kinase
BRN66_RS13255	COG3039	Transposase
BRN66_RS13350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRN66_RS13355	COG4988	ABC transporter
BRN66_RS13380	COG1271	oxidase subunit
BRN66_RS13415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRN66_RS13435	COG0165	Argininosuccinate lyase
BRN66_RS13450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRN66_RS13455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN66_RS13465	COG0137	argininosuccinate synthase activity
BRN66_RS13470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRN66_RS13485	COG2166	iron-sulfur cluster assembly
BRN66_RS13510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRN66_RS13550	COG3039	Transposase
BRN66_RS13565	COG4677	pectinesterase activity
BRN66_RS13595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRN66_RS13600	COG0402	S-adenosylhomocysteine deaminase activity
BRN66_RS13615	COG1509	lysine 2,3-aminomutase activity
BRN66_RS13620	COG5001	Diguanylate cyclase
BRN66_RS13620	COG3300	MHYT domain
BRN66_RS13635	COG0483	inositol monophosphate 1-phosphatase activity
BRN66_RS13640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN66_RS13665	COG0488	(ABC) transporter
BRN66_RS13670	COG0513	Belongs to the DEAD box helicase family
BRN66_RS13690	COG0625	glutathione transferase activity
BRN66_RS13700	COG1671	Belongs to the UPF0178 family
BRN66_RS13705	COG4681	YaeQ
BRN66_RS13710	COG2081	HI0933 family
BRN66_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS13755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRN66_RS13760	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN66_RS13765	COG0802	atpase or kinase
BRN66_RS13770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRN66_RS13770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRN66_RS13775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN66_RS13800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN66_RS13885	COG3328	transposase activity
BRN66_RS13930	COG2969	positive regulation of protein catabolic process
BRN66_RS13935	COG0625	glutathione transferase activity
BRN66_RS13940	COG2857	Cytochrome c1
BRN66_RS13945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRN66_RS13950	COG0723	plastoquinol--plastocyanin reductase activity
BRN66_RS13960	COG0741	lytic transglycosylase activity
BRN66_RS13985	COG1702	phosphate starvation-inducible protein PhoH
BRN66_RS14005	COG4535	Mg2 and Co2 transporter CorC
BRN66_RS14020	COG1012	belongs to the aldehyde dehydrogenase family
BRN66_RS14030	COG1177	transmembrane transport
BRN66_RS14040	COG3842	ATPase activity
BRN66_RS14080	COG0174	glutamine synthetase
BRN66_RS14085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_RS14095	COG0477	Major facilitator Superfamily
BRN66_RS14105	COG0243	molybdopterin cofactor binding
BRN66_RS14115	COG2223	nitrite transmembrane transporter activity
BRN66_RS14135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BRN66_RS14140	COG1121	(ABC) transporter
BRN66_RS14150	COG2733	membrane
BRN66_RS14155	COG0784	Response regulator, receiver
BRN66_RS14155	COG2205	protein histidine kinase activity
BRN66_RS14155	COG5002	protein histidine kinase activity
BRN66_RS14165	COG3039	Transposase
BRN66_RS14175	COG2902	Dehydrogenase
BRN66_RS14185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_RS14190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_RS14210	COG1609	Transcriptional regulator
BRN66_RS14215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN66_RS14215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN66_RS14220	COG1105	Belongs to the carbohydrate kinase PfkB family
BRN66_RS14225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN66_RS14225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN66_RS14245	COG3039	Transposase
BRN66_RS14370	COG3039	Transposase
BRN66_RS14380	COG3039	Transposase
BRN66_RS14405	COG4771	TonB-dependent receptor
BRN66_RS14415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN66_RS14435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRN66_RS14440	COG1360	Flagellar Motor Protein
BRN66_RS14450	COG0835	chemotaxis
BRN66_RS14460	COG0745	RESPONSE REGULATOR receiver
BRN66_RS14485	COG0840	transmembrane signaling receptor activity
BRN66_RS14500	COG0840	transmembrane signaling receptor activity
BRN66_RS14510	COG0840	transmembrane signaling receptor activity
BRN66_RS14520	COG0840	transmembrane signaling receptor activity
BRN66_RS14525	COG0840	transmembrane signaling receptor activity
BRN66_RS14530	COG0840	transmembrane signaling receptor activity
BRN66_RS14535	COG0840	transmembrane signaling receptor activity
BRN66_RS14555	COG0835	chemotaxis
BRN66_RS14580	COG0840	transmembrane signaling receptor activity
BRN66_RS14615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN66_RS14645	COG0318	PFAM AMP-dependent synthetase and ligase
BRN66_RS14650	COG1024	Enoyl-CoA hydratase
BRN66_RS14655	COG2205	protein histidine kinase activity
BRN66_RS14655	COG2198	Histidine kinase
BRN66_RS14655	COG0784	Response regulator, receiver
BRN66_RS14725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRN66_RS14735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN66_RS14740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRN66_RS14750	COG0505	Belongs to the CarA family
BRN66_RS14755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRN66_RS14765	COG2258	MOSC domain
BRN66_RS14770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRN66_RS14820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRN66_RS14840	COG0477	Major facilitator Superfamily
BRN66_RS14850	COG1070	Carbohydrate kinase
BRN66_RS14860	COG1501	Belongs to the glycosyl hydrolase 31 family
BRN66_RS14875	COG0800	Aldolase
BRN66_RS14880	COG4948	Mandelate Racemase Muconate Lactonizing
BRN66_RS14890	COG3734	2-keto-3-deoxy-galactonokinase
BRN66_RS14895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRN66_RS14905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN66_RS14920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRN66_RS14925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRN66_RS14935	COG0351	phosphomethylpyrimidine kinase
BRN66_RS14965	COG0583	DNA-binding transcription factor activity
BRN66_RS14970	COG1741	Belongs to the pirin family
BRN66_RS14990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRN66_RS14995	COG0305	Participates in initiation and elongation during chromosome replication
BRN66_RS15020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRN66_RS15025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRN66_RS15030	COG2137	regulation of response to DNA damage stimulus
BRN66_RS15040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRN66_RS15055	COG1546	Belongs to the CinA family
BRN66_RS15060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRN66_RS15075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRN66_RS15085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRN66_RS15090	COG1534	Rna-binding protein
BRN66_RS15105	COG1238	metal cluster binding
BRN66_RS15110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRN66_RS15115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRN66_RS15120	COG2840	Smr protein MutS2
BRN66_RS15135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRN66_RS15150	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRN66_RS15155	COG0148	phosphopyruvate hydratase activity
BRN66_RS15165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRN66_RS15170	COG0504	CTP synthase activity
BRN66_RS15195	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BRN66_RS15200	COG0306	phosphate transporter
BRN66_RS15215	COG1253	flavin adenine dinucleotide binding
BRN66_RS15230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRN66_RS15250	COG0477	Major facilitator Superfamily
BRN66_RS15260	COG1132	(ABC) transporter
BRN66_RS15265	COG1136	(ABC) transporter
BRN66_RS15285	COG0438	transferase activity, transferring glycosyl groups
BRN66_RS15295	COG2264	protein methyltransferase activity
BRN66_RS15325	COG2244	polysaccharide biosynthetic process
BRN66_RS15375	COG1595	DNA-templated transcription, initiation
BRN66_RS15390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN66_RS15410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN66_RS15465	COG2201	protein-glutamate methylesterase activity
BRN66_RS15485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_RS15490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_RS15545	COG1858	cytochrome C peroxidase
BRN66_RS15580	COG0515	serine threonine protein kinase
BRN66_RS15585	COG0631	protein serine/threonine phosphatase activity
BRN66_RS15700	COG3039	Transposase
BRN66_RS15720	COG3039	Transposase
BRN66_RS15765	COG0316	Belongs to the HesB IscA family
BRN66_RS15765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRN66_RS15770	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRN66_RS15780	COG0428	transporter
BRN66_RS15785	COG0428	transporter
BRN66_RS15790	COG3064	Membrane
BRN66_RS15800	COG1530	ribonuclease E activity
BRN66_RS15820	COG1054	Belongs to the UPF0176 family
BRN66_RS15825	COG3039	Transposase
BRN66_RS15845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRN66_RS15885	COG3039	Transposase
BRN66_RS15890	COG3039	Transposase
BRN66_RS15920	COG1648	precorrin-2 dehydrogenase activity
BRN66_RS15920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRN66_RS15945	COG0746	molybdenum cofactor guanylyltransferase activity
BRN66_RS16020	COG3328	transposase activity
BRN66_RS16025	COG4206	TonB-dependent receptor
BRN66_RS16060	COG4206	TonB-dependent receptor
BRN66_RS16110	COG0531	amino acid
BRN66_RS16125	COG0006	proline dipeptidase activity
BRN66_RS16135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN66_RS16150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_RS16155	COG3938	Belongs to the proline racemase family
BRN66_RS16165	COG0552	protein localization to endoplasmic reticulum
BRN66_RS16190	COG0784	Response regulator, receiver
BRN66_RS16190	COG4191	Histidine kinase
BRN66_RS16280	COG3040	lipid binding
BRN66_RS16320	COG0438	transferase activity, transferring glycosyl groups
BRN66_RS16330	COG0438	transferase activity, transferring glycosyl groups
BRN66_RS16335	COG0438	transferase activity, transferring glycosyl groups
BRN66_RS16405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRN66_RS16445	COG4969	Belongs to the N-Me-Phe pilin family
BRN66_RS16485	COG1611	Belongs to the LOG family
BRN66_RS16500	COG2095	MarC family integral membrane protein
BRN66_RS16510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN66_RS16545	COG1185	polyribonucleotide nucleotidyltransferase activity
BRN66_RS16550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRN66_RS16570	COG0195	Participates in both transcription termination and antitermination
BRN66_RS16575	COG0779	Required for maturation of 30S ribosomal subunits
BRN66_RS16585	COG1007	ATP synthesis coupled electron transport
BRN66_RS16620	COG1034	ATP synthesis coupled electron transport
BRN66_RS16625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRN66_RS16630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRN66_RS16635	COG0649	NAD binding
BRN66_RS16640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRN66_RS16650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRN66_RS16665	COG0149	triose-phosphate isomerase activity
BRN66_RS16715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRN66_RS16720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRN66_RS16745	COG0135	phosphoribosylanthranilate isomerase activity
BRN66_RS16750	COG0101	tRNA pseudouridine synthase activity
BRN66_RS16770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRN66_RS16775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRN66_RS16780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRN66_RS16785	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN66_RS16840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN66_RS16850	COG0412	Dienelactone hydrolase
BRN66_RS16875	COG0717	Belongs to the dCTP deaminase family
BRN66_RS16880	COG0489	protein tyrosine kinase activity
BRN66_RS16925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_RS16930	COG2311	Membrane
BRN66_RS16935	COG1047	Peptidyl-prolyl cis-trans
BRN66_RS16940	COG0791	NLP P60 protein
BRN66_RS16945	COG0791	NLP P60 protein
BRN66_RS16960	COG1301	dicarboxylic acid transport
BRN66_RS16965	COG1785	Belongs to the alkaline phosphatase family
BRN66_RS16970	COG0037	tRNA processing
BRN66_RS16975	COG1722	exodeoxyribonuclease VII activity
BRN66_RS16980	COG0142	geranyltranstransferase activity
BRN66_RS17005	COG0312	modulator of DNA gyrase
BRN66_RS17010	COG3028	Belongs to the UPF0307 family
BRN66_RS17015	COG0312	modulator of DNA gyrase
BRN66_RS17025	COG3164	Protein of unknown function
BRN66_RS17040	COG2968	Membrane
BRN66_RS17065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRN66_RS17090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRN66_RS17120	COG3118	belongs to the thioredoxin family
BRN66_RS17200	COG3039	Transposase
BRN66_RS17205	COG3039	Transposase
BRN66_RS17300	COG2022	thiamine diphosphate biosynthetic process
BRN66_RS17315	COG3273	potassium ion transport
BRN66_RS17315	COG0471	metal ion transport
BRN66_RS17345	COG1970	mechanosensitive ion channel activity
BRN66_RS17370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN66_RS17400	COG0308	aminopeptidase N
BRN66_RS17405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_RS17420	COG2895	sulfate adenylyltransferase (ATP) activity
BRN66_RS17420	COG0529	Catalyzes the synthesis of activated sulfate
BRN66_RS17425	COG0175	sulfate reduction
BRN66_RS17430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN66_RS17435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BRN66_RS17440	COG0175	sulfate reduction
BRN66_RS17460	COG2198	Histidine kinase
BRN66_RS17460	COG2205	protein histidine kinase activity
BRN66_RS17460	COG0784	Response regulator, receiver
BRN66_RS17505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRN66_RS17510	COG3588	fructose-bisphosphate aldolase
BRN66_RS17515	COG0469	pyruvate kinase activity
BRN66_RS17560	COG0753	catalase activity
BRN66_RS17585	COG3039	Transposase
BRN66_RS17605	COG2207	Transcriptional regulator
BRN66_RS17605	COG1917	Cupin 2, conserved barrel domain protein
BRN66_RS17635	COG0823	Involved in the tonB-independent uptake of proteins
BRN66_RS17635	COG1506	peptidase
BRN66_RS17660	COG3039	Transposase
BRN66_RS17665	COG1297	OPT oligopeptide transporter protein
BRN66_RS17770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRN66_RS17775	COG3039	Transposase
BRN66_RS17790	COG0732	type I restriction modification DNA specificity domain
BRN66_RS17795	COG3039	Transposase
BRN66_RS17805	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRN66_RS17810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRN66_RS17830	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRN66_RS18030	COG3179	chitinase
BRN66_RS18050	COG3039	Transposase
BRN66_RS18145	COG3039	Transposase
BRN66_RS18160	COG3039	Transposase
BRN66_RS18290	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRN66_RS18305	COG2197	response regulator
BRN66_RS18310	COG4585	Histidine kinase
BRN66_RS18330	COG2894	cell division
BRN66_RS18335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRN66_RS18345	COG0642	Histidine kinase
BRN66_RS18350	COG0745	RESPONSE REGULATOR receiver
BRN66_RS18355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRN66_RS18365	COG2194	sulfuric ester hydrolase activity
BRN66_RS18395	COG3551	Protein conserved in bacteria
BRN66_RS18460	COG0203	ribosomal protein L17
BRN66_RS18470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRN66_RS18475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRN66_RS18485	COG0201	protein transport
BRN66_RS18495	COG1841	ribosomal large subunit assembly
BRN66_RS18525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRN66_RS18535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRN66_RS18540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRN66_RS18545	COG0255	Belongs to the universal ribosomal protein uL29 family
BRN66_RS18550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRN66_RS18560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRN66_RS18575	COG0089	rRNA binding
BRN66_RS18580	COG0088	Forms part of the polypeptide exit tunnel
BRN66_RS18585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRN66_RS18590	COG0051	transcription antitermination factor activity, RNA binding
BRN66_RS18615	COG0049	tRNA binding
BRN66_RS18620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRN66_RS18625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRN66_RS18630	COG0085	RNA polymerase activity
BRN66_RS18635	COG0222	ribosome binding
BRN66_RS18640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRN66_RS18650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRN66_RS18660	COG0250	Participates in transcription elongation, termination and antitermination
BRN66_RS18665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRN66_RS18695	COG0012	GTP binding
BRN66_RS18700	COG0193	aminoacyl-tRNA hydrolase activity
BRN66_RS18710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRN66_RS18725	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BRN66_RS18740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRN66_RS18750	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRN66_RS18770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN66_RS18775	COG1295	ribonuclease BN
BRN66_RS18805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRN66_RS18815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRN66_RS18845	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRN66_RS18870	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN66_RS18885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN66_RS18885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN66_RS18935	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN66_RS18945	COG3634	alkyl hydroperoxide reductase activity
BRN66_RS18950	COG0583	DNA-binding transcription factor activity
BRN66_RS18960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN66_RS19040	COG4783	chaperone-mediated protein folding
BRN66_RS19055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRN66_RS19065	COG0438	transferase activity, transferring glycosyl groups
BRN66_RS19070	COG0671	phosphoesterase, PA-phosphatase related
BRN66_RS19075	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRN66_RS19095	COG2833	Protein of unknown function (DUF455)
BRN66_RS19115	COG0285	dihydrofolate synthase activity
BRN66_RS19125	COG0406	alpha-ribazole phosphatase activity
BRN66_RS19160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRN66_RS19165	COG4208	sulfate ABC transporter
BRN66_RS19170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRN66_RS19175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRN66_RS19180	COG0156	8-amino-7-oxononanoate synthase activity
BRN66_RS19210	COG0604	alcohol dehydrogenase
BRN66_RS19215	COG1902	pentaerythritol trinitrate reductase activity
BRN66_RS19215	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRN66_RS19350	COG3386	PFAM SMP-30 Gluconolaconase
BRN66_RS19370	COG1024	Enoyl-CoA hydratase
BRN66_RS19380	COG0318	PFAM AMP-dependent synthetase and ligase
BRN66_RS19385	COG0583	DNA-binding transcription factor activity
BRN66_RS19425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN66_RS19430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN66_RS19440	COG2096	Adenosyltransferase
BRN66_RS19445	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRN66_RS19460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRN66_RS19470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRN66_RS19475	COG2967	ApaG domain
BRN66_RS19500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRN66_RS19520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRN66_RS19545	COG0642	Histidine kinase
BRN66_RS19560	COG4181	ATPase activity
BRN66_RS19570	COG2175	clavaminate synthase activity
BRN66_RS19580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BRN66_RS19620	COG0667	Aldo Keto reductase
BRN66_RS19630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRN66_RS19635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN66_RS19655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN66_RS19670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRN66_RS19725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRN66_RS19730	COG2226	methyltransferase
BRN66_RS19785	COG3321	synthase
BRN66_RS19785	COG0604	alcohol dehydrogenase
BRN66_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS19800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRN66_RS19815	COG0494	nUDIX hydrolase
BRN66_RS19830	COG1388	LysM domain
BRN66_RS19830	COG4942	peptidase
BRN66_RS19840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRN66_RS19855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRN66_RS19860	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN66_RS19865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRN66_RS19880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN66_RS19885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRN66_RS19900	COG3116	cell division
BRN66_RS19905	COG0275	rRNA processing
BRN66_RS19940	COG0792	nuclease activity
BRN66_RS19945	COG1988	membrane-bound metal-dependent
BRN66_RS19950	COG0277	FAD linked oxidase domain protein
BRN66_RS19955	COG0745	RESPONSE REGULATOR receiver
BRN66_RS19960	COG2205	protein histidine kinase activity
BRN66_RS19970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRN66_RS19975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRN66_RS20000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRN66_RS20005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRN66_RS20010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BRN66_RS20030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN66_RS20030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN66_RS20050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRN66_RS20070	COG0488	(ABC) transporter
BRN66_RS20120	COG2205	protein histidine kinase activity
BRN66_RS20160	COG2205	protein histidine kinase activity
BRN66_RS20180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRN66_RS20215	COG3039	Transposase
BRN66_RS20220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRN66_RS20235	COG3039	Transposase
BRN66_RS20290	COG3039	Transposase
BRN66_RS20340	COG1649	PFAM Uncharacterised BCR, COG1649
BRN66_RS20340	COG0726	polysaccharide deacetylase
BRN66_RS20345	COG1215	transferase activity, transferring glycosyl groups
BRN66_RS20355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRN66_RS20360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN66_RS20365	COG1609	Transcriptional regulator
BRN66_RS20375	COG2188	Transcriptional regulator
BRN66_RS20390	COG3250	beta-galactosidase activity
BRN66_RS20445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRN66_RS20450	COG4191	Histidine kinase
BRN66_RS20455	COG0784	Response regulator, receiver
BRN66_RS20460	COG4251	negative regulation of phosphorylation
BRN66_RS20465	COG2823	Periplasmic or secreted lipoprotein
BRN66_RS20470	COG0673	inositol 2-dehydrogenase activity
BRN66_RS20475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRN66_RS20510	COG1056	cytidyltransferase-related domain
BRN66_RS20510	COG1051	belongs to the nudix hydrolase family
BRN66_RS20545	COG2921	Belongs to the UPF0250 family
BRN66_RS20560	COG1686	Belongs to the peptidase S11 family
BRN66_RS20570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRN66_RS20575	COG2951	lytic endotransglycosylase activity
BRN66_RS20590	COG1388	LysM domain
BRN66_RS20590	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRN66_RS20590	COG3409	Peptidoglycan-binding domain 1 protein
BRN66_RS20635	COG0772	Belongs to the SEDS family
BRN66_RS20650	COG1792	Involved in formation and maintenance of cell shape
BRN66_RS20655	COG1077	Cell shape determining protein MreB Mrl
BRN66_RS20660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN66_RS20705	COG2199	diguanylate cyclase activity
BRN66_RS20710	COG0308	aminopeptidase N
BRN66_RS20740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRN66_RS20770	COG0436	Aminotransferase
BRN66_RS20785	COG1505	serine-type exopeptidase activity
BRN66_RS20810	COG0181	hydroxymethylbilane synthase activity
BRN66_RS20820	COG3275	phosphorelay sensor kinase activity
BRN66_RS20865	COG0659	secondary active sulfate transmembrane transporter activity
BRN66_RS20870	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_RS20870	COG5297	Belongs to the glycosyl hydrolase family 6
BRN66_RS20945	COG0598	Magnesium transport protein CorA
BRN66_RS20955	COG1113	amino acid transport
BRN66_RS20965	COG5297	Belongs to the glycosyl hydrolase family 6
BRN66_RS20970	COG4305	rare lipoprotein A
BRN66_RS20975	COG0697	spore germination
BRN66_RS21035	COG4221	oxidoreductase activity
BRN66_RS21065	COG0456	acetyltransferase
BRN66_RS21075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRN66_RS21135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN66_RS21135	COG2111	Na H antiporter
BRN66_RS21140	COG1006	Multisubunit Na H antiporter MnhC subunit
BRN66_RS21145	COG0651	ATP synthesis coupled electron transport
BRN66_RS21155	COG2212	antiporter activity
BRN66_RS21160	COG1320	monovalent cation:proton antiporter activity
BRN66_RS21170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BRN66_RS21190	COG3104	oligopeptide transport
BRN66_RS21195	COG3483	tryptophan 2,3-dioxygenase activity
BRN66_RS21205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRN66_RS21240	COG0183	Belongs to the thiolase family
BRN66_RS21295	COG3039	Transposase
BRN66_RS21325	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRN66_RS21330	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRN66_RS21340	COG4948	Mandelate Racemase Muconate Lactonizing
BRN66_RS21380	COG0531	amino acid
BRN66_RS21415	COG4682	membrane
BRN66_RS21420	COG2133	pyrroloquinoline quinone binding
BRN66_RS21460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRN66_RS21465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRN66_RS21475	COG1610	YqeY-like protein
BRN66_RS21490	COG1295	ribonuclease BN
BRN66_RS21495	COG0358	DNA primase activity
BRN66_RS21560	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRN66_RS21575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRN66_RS21625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRN66_RS21630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRN66_RS21635	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BRN66_RS21645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BRN66_RS21650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRN66_RS21665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRN66_RS21745	COG3039	Transposase
BRN66_RS21760	COG3328	transposase activity
BRN66_RS21775	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRN66_RS21775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BRN66_RS21785	COG1473	amidohydrolase
BRN66_RS21790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_RS21795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_RS21810	COG5383	Protein conserved in bacteria
BRN66_RS21850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN66_RS21855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRN66_RS21870	COG0028	Belongs to the TPP enzyme family
BRN66_RS21875	COG4191	Histidine kinase
BRN66_RS21900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRN66_RS21915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN66_RS21920	COG3177	Filamentation induced by cAMP protein fic
BRN66_RS21935	COG0596	Alpha beta hydrolase
BRN66_RS21940	COG0727	PFAM Uncharacterised protein family (UPF0153)
BRN66_RS21945	COG0318	PFAM AMP-dependent synthetase and ligase
BRN66_RS21950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRN66_RS22005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRN66_RS22015	COG0129	dihydroxy-acid dehydratase activity
BRN66_RS22040	COG3039	Transposase
BRN66_RS22050	COG0408	coproporphyrinogen oxidase activity
BRN66_RS22150	COG2353	YceI-like domain
BRN66_RS22180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN66_RS22195	COG3386	PFAM SMP-30 Gluconolaconase
BRN66_RS22235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRN66_RS22250	COG4771	TonB-dependent receptor
BRN66_RS22260	COG0459	protein refolding
BRN66_RS22285	COG1252	NADH dehydrogenase
BRN66_RS22295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN66_RS22300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRN66_RS22305	COG3437	response regulator, receiver
BRN66_RS22310	COG2177	Part of the ABC transporter FtsEX involved in
BRN66_RS22315	COG2884	Cell division ATP-binding protein ftsE
BRN66_RS22325	COG3118	belongs to the thioredoxin family
BRN66_RS22330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRN66_RS22345	COG0729	surface antigen
BRN66_RS22350	COG2911	Protein conserved in bacteria
BRN66_RS22385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRN66_RS22400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRN66_RS22460	COG1733	regulation of RNA biosynthetic process
BRN66_RS22465	COG0702	epimerase
BRN66_RS22500	COG0583	DNA-binding transcription factor activity
BRN66_RS22505	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN66_RS22525	COG0745	RESPONSE REGULATOR receiver
BRN66_RS22555	COG1902	pentaerythritol trinitrate reductase activity
BRN66_RS22560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRN66_RS22570	COG2814	Major facilitator Superfamily
BRN66_RS22575	COG0583	DNA-binding transcription factor activity
BRN66_RS22595	COG0084	hydrolase, TatD family'
BRN66_RS22645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRN66_RS22665	COG2072	flavoprotein involved in K transport
BRN66_RS22715	COG4770	biotin carboxylase activity
BRN66_RS22720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRN66_RS22725	COG1960	acyl-CoA dehydrogenase activity
BRN66_RS22780	COG0523	cobalamin synthesis protein
BRN66_RS22790	COG0697	spore germination
BRN66_RS22800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRN66_RS22815	COG4771	TonB-dependent receptor
BRN66_RS22820	COG0457	Tetratricopeptide repeat
BRN66_RS22835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN66_RS22865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRN66_RS22865	COG0519	Catalyzes the synthesis of GMP from XMP
BRN66_RS22875	COG0805	protein transport
BRN66_RS22885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRN66_RS22895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRN66_RS22950	COG3661	Belongs to the glycosyl hydrolase 67 family
BRN66_RS22960	COG4948	Mandelate Racemase Muconate Lactonizing
BRN66_RS22970	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN66_RS22975	COG0246	Mannitol dehydrogenase
BRN66_RS23000	COG3693	PFAM glycoside hydrolase, family 10
BRN66_RS23025	COG2211	Major facilitator Superfamily
BRN66_RS23070	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRN66_RS23120	COG1846	Transcriptional regulator
BRN66_RS23125	COG1764	response to oxidative stress
BRN66_RS23225	COG3549	Plasmid maintenance system killer
BRN66_RS23235	COG1074	ATP-dependent DNA helicase activity
BRN66_RS23240	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRN66_RS23280	COG2032	superoxide dismutase activity
BRN66_RS23285	COG2032	superoxide dismutase activity
BRN66_RS23290	COG2204	response regulator
BRN66_RS23295	COG3852	Histidine kinase
BRN66_RS23300	COG0004	ammonium transporteR
BRN66_RS23305	COG0347	Belongs to the P(II) protein family
BRN66_RS23310	COG0174	glutamine synthetase
BRN66_RS23315	COG1968	undecaprenyl-diphosphatase activity
BRN66_RS23360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN66_RS23370	COG2062	phosphohistidine phosphatase, SixA
BRN66_RS23375	COG0489	protein tyrosine kinase activity
BRN66_RS23395	COG1396	sequence-specific DNA binding
BRN66_RS23400	COG3550	peptidyl-serine autophosphorylation
BRN66_RS23405	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRN66_RS23410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN66_RS23425	COG1125	glycine betaine transport
BRN66_RS23425	COG0517	IMP dehydrogenase activity
BRN66_RS23440	COG1119	ATPase activity
BRN66_RS23450	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRN66_RS23465	COG3039	Transposase
BRN66_RS23490	COG0656	L-ascorbic acid biosynthetic process
BRN66_RS23495	COG2130	NADP-dependent
BRN66_RS23500	COG0667	Aldo Keto reductase
BRN66_RS23510	COG1187	pseudouridine synthase activity
BRN66_RS23525	COG1643	Atp-dependent helicase
BRN66_RS23530	COG4807	Protein conserved in bacteria
BRN66_RS23535	COG4948	Mandelate Racemase Muconate Lactonizing
BRN66_RS23545	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRN66_RS23550	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_RS23570	COG3507	Belongs to the glycosyl hydrolase 43 family
BRN66_RS23615	COG3162	membrane
BRN66_RS23620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRN66_RS23635	COG0708	Exodeoxyribonuclease III
BRN66_RS23650	COG2091	lysine biosynthetic process via aminoadipic acid
BRN66_RS23660	COG3540	Alkaline phosphatase
BRN66_RS23690	COG2159	amidohydrolase
BRN66_RS23715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRN66_RS23720	COG0583	DNA-binding transcription factor activity
BRN66_RS23725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN66_RS23745	COG0210	DNA helicase
BRN66_RS23760	COG0531	amino acid
BRN66_RS23770	COG1322	Protein conserved in bacteria
BRN66_RS23780	COG0386	Belongs to the glutathione peroxidase family
BRN66_RS23835	COG0793	Belongs to the peptidase S41A family
BRN66_RS23840	COG4942	peptidase
BRN66_RS23850	COG2234	aminopeptidase activity
BRN66_RS23900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN66_RS23905	COG0302	gtp cyclohydrolase
BRN66_RS23930	COG0477	Major facilitator Superfamily
BRN66_RS24040	COG1929	Belongs to the glycerate kinase type-1 family
BRN66_RS24045	COG2271	Major facilitator Superfamily
BRN66_RS24060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRN66_RS24070	COG0861	Integral membrane protein TerC family
BRN66_RS24080	COG0584	glycerophosphoryl diester phosphodiesterase
BRN66_RS24090	COG0671	phosphoesterase, PA-phosphatase related
BRN66_RS24100	COG0726	polysaccharide deacetylase