locus-tag	class	description
BO993_RS00140	COG3039	Transposase
BO993_RS00180	COG3039	Transposase
BO993_RS00200	COG4695	Portal protein
BO993_RS00245	COG3179	chitinase
BO993_RS00460	COG1611	Belongs to the LOG family
BO993_RS00475	COG2095	MarC family integral membrane protein
BO993_RS00485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BO993_RS00520	COG1185	polyribonucleotide nucleotidyltransferase activity
BO993_RS00525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BO993_RS00540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BO993_RS00545	COG0195	Participates in both transcription termination and antitermination
BO993_RS00550	COG0779	Required for maturation of 30S ribosomal subunits
BO993_RS00560	COG1007	ATP synthesis coupled electron transport
BO993_RS00590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BO993_RS00595	COG1034	ATP synthesis coupled electron transport
BO993_RS00600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BO993_RS00605	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BO993_RS00610	COG0649	NAD binding
BO993_RS00615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BO993_RS00625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BO993_RS00640	COG0149	triose-phosphate isomerase activity
BO993_RS00695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BO993_RS00700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BO993_RS00710	COG0159	tryptophan synthase activity
BO993_RS00730	COG0135	phosphoribosylanthranilate isomerase activity
BO993_RS00735	COG0101	tRNA pseudouridine synthase activity
BO993_RS00755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BO993_RS00760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BO993_RS00765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BO993_RS00770	COG2890	protein-(glutamine-N5) methyltransferase activity
BO993_RS00825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BO993_RS00835	COG0412	Dienelactone hydrolase
BO993_RS00855	COG0717	Belongs to the dCTP deaminase family
BO993_RS00860	COG0489	protein tyrosine kinase activity
BO993_RS00905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO993_RS00910	COG2311	Membrane
BO993_RS00915	COG1047	Peptidyl-prolyl cis-trans
BO993_RS00920	COG0791	NLP P60 protein
BO993_RS00925	COG0791	NLP P60 protein
BO993_RS00945	COG1301	dicarboxylic acid transport
BO993_RS00950	COG1785	Belongs to the alkaline phosphatase family
BO993_RS00955	COG0037	tRNA processing
BO993_RS00960	COG1722	exodeoxyribonuclease VII activity
BO993_RS00965	COG0142	geranyltranstransferase activity
BO993_RS00990	COG0312	modulator of DNA gyrase
BO993_RS00995	COG3028	Belongs to the UPF0307 family
BO993_RS01000	COG0312	modulator of DNA gyrase
BO993_RS01010	COG3164	Protein of unknown function
BO993_RS01025	COG2968	Membrane
BO993_RS01055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BO993_RS01080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BO993_RS01110	COG3118	belongs to the thioredoxin family
BO993_RS01245	COG2022	thiamine diphosphate biosynthetic process
BO993_RS01260	COG3273	potassium ion transport
BO993_RS01260	COG0471	metal ion transport
BO993_RS01290	COG1970	mechanosensitive ion channel activity
BO993_RS01315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BO993_RS01345	COG0308	aminopeptidase N
BO993_RS01350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO993_RS01365	COG3039	Transposase
BO993_RS01375	COG0529	Catalyzes the synthesis of activated sulfate
BO993_RS01375	COG2895	sulfate adenylyltransferase (ATP) activity
BO993_RS01380	COG0175	sulfate reduction
BO993_RS01385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BO993_RS01390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BO993_RS01395	COG0175	sulfate reduction
BO993_RS01420	COG2205	protein histidine kinase activity
BO993_RS01420	COG2198	Histidine kinase
BO993_RS01420	COG0784	Response regulator, receiver
BO993_RS01470	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BO993_RS01475	COG3588	fructose-bisphosphate aldolase
BO993_RS01480	COG0469	pyruvate kinase activity
BO993_RS01490	COG0126	phosphoglycerate kinase activity
BO993_RS01525	COG0753	catalase activity
BO993_RS01555	COG2207	Transcriptional regulator
BO993_RS01555	COG1917	Cupin 2, conserved barrel domain protein
BO993_RS01575	COG0823	Involved in the tonB-independent uptake of proteins
BO993_RS01575	COG1506	peptidase
BO993_RS01600	COG1297	OPT oligopeptide transporter protein
BO993_RS01620	COG0587	DNA-directed DNA polymerase activity
BO993_RS01700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BO993_RS01715	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BO993_RS01720	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BO993_RS01725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BO993_RS01745	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BO993_RS01810	COG3039	Transposase
BO993_RS01825	COG3039	Transposase
BO993_RS01945	COG3179	chitinase
BO993_RS02010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BO993_RS02020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BO993_RS02030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BO993_RS02135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BO993_RS02160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BO993_RS02175	COG2197	response regulator
BO993_RS02180	COG4585	Histidine kinase
BO993_RS02200	COG2894	cell division
BO993_RS02205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BO993_RS02215	COG0642	Histidine kinase
BO993_RS02220	COG0745	RESPONSE REGULATOR receiver
BO993_RS02225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BO993_RS02235	COG2194	sulfuric ester hydrolase activity
BO993_RS02265	COG3551	Protein conserved in bacteria
BO993_RS02330	COG0203	ribosomal protein L17
BO993_RS02340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BO993_RS02345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BO993_RS02355	COG0201	protein transport
BO993_RS02365	COG1841	ribosomal large subunit assembly
BO993_RS02395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BO993_RS02405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BO993_RS02410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BO993_RS02415	COG0255	Belongs to the universal ribosomal protein uL29 family
BO993_RS02420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BO993_RS02430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BO993_RS02445	COG0089	rRNA binding
BO993_RS02450	COG0088	Forms part of the polypeptide exit tunnel
BO993_RS02455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BO993_RS02460	COG0051	transcription antitermination factor activity, RNA binding
BO993_RS02480	COG0049	tRNA binding
BO993_RS02485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BO993_RS02490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BO993_RS02495	COG0085	RNA polymerase activity
BO993_RS02500	COG0222	ribosome binding
BO993_RS02505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BO993_RS02515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BO993_RS02525	COG0250	Participates in transcription elongation, termination and antitermination
BO993_RS02530	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BO993_RS02560	COG0012	GTP binding
BO993_RS02565	COG0193	aminoacyl-tRNA hydrolase activity
BO993_RS02575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BO993_RS02590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BO993_RS02600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BO993_RS02605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BO993_RS02615	COG0521	Mo-molybdopterin cofactor biosynthetic process
BO993_RS02635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BO993_RS02640	COG1295	ribonuclease BN
BO993_RS02670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BO993_RS02680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BO993_RS02710	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BO993_RS02735	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BO993_RS02750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BO993_RS02750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BO993_RS02790	COG2890	protein-(glutamine-N5) methyltransferase activity
BO993_RS02800	COG3634	alkyl hydroperoxide reductase activity
BO993_RS02805	COG0583	DNA-binding transcription factor activity
BO993_RS02815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BO993_RS02820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BO993_RS02865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BO993_RS02905	COG0584	glycerophosphoryl diester phosphodiesterase
BO993_RS02945	COG0625	glutathione transferase activity
BO993_RS02975	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BO993_RS03130	COG3781	membrane
BO993_RS03140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BO993_RS03175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BO993_RS03195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BO993_RS03220	COG3710	Transcriptional regulator
BO993_RS03225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BO993_RS03235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BO993_RS03265	COG2226	methyltransferase
BO993_RS03270	COG0066	3-isopropylmalate dehydratase activity
BO993_RS03275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BO993_RS03305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BO993_RS03310	COG1538	Outer membrane efflux protein
BO993_RS03315	COG1519	Transferase
BO993_RS03320	COG1560	Kdo2-lipid A biosynthetic process
BO993_RS03380	COG0308	aminopeptidase N
BO993_RS03385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BO993_RS03395	COG0330	HflC and HflK could
BO993_RS03400	COG0330	HflC and HflK could
BO993_RS03420	COG0678	peroxiredoxin activity
BO993_RS03430	COG2826	transposase and inactivated derivatives, IS30 family
BO993_RS03525	COG3829	transcription factor binding
BO993_RS03560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BO993_RS03565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BO993_RS03575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BO993_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS03605	COG1399	metal-binding, possibly nucleic acid-binding protein
BO993_RS03630	COG3039	Transposase
BO993_RS03665	COG1518	maintenance of DNA repeat elements
BO993_RS03670	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BO993_RS03725	COG2188	Transcriptional regulator
BO993_RS03740	COG1450	Type ii and iii secretion system protein
BO993_RS03755	COG3166	PFAM Fimbrial assembly family protein
BO993_RS03760	COG3156	type II secretion system protein K
BO993_RS03765	COG4795	General secretion pathway protein
BO993_RS03770	COG2165	general secretion pathway protein
BO993_RS03775	COG4970	Tfp pilus assembly protein FimT
BO993_RS03780	COG2165	general secretion pathway protein
BO993_RS03785	COG1459	type II secretion system
BO993_RS03795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BO993_RS03805	COG5295	Hep Hag repeat protein
BO993_RS03815	COG0047	phosphoribosylformylglycinamidine synthase activity
BO993_RS03815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BO993_RS03820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BO993_RS03825	COG4974	Belongs to the 'phage' integrase family
BO993_RS03840	COG0795	lipopolysaccharide-transporting ATPase activity
BO993_RS03850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BO993_RS03865	COG0525	valine-tRNA ligase activity
BO993_RS03975	COG1183	phosphatidylcholine synthase activity
BO993_RS03985	COG0442	prolyl-tRNA aminoacylation
BO993_RS04000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BO993_RS04005	COG1127	ABC transporter
BO993_RS04010	COG3218	ABC-type transport auxiliary lipoprotein component
BO993_RS04010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BO993_RS04050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BO993_RS04055	COG0662	Cupin 2, conserved barrel domain protein
BO993_RS04055	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BO993_RS04080	COG2086	electron transfer activity
BO993_RS04095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BO993_RS04095	COG0546	phosphoglycolate phosphatase activity
BO993_RS04100	COG0277	FAD linked oxidase domain protein
BO993_RS04115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BO993_RS04120	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BO993_RS04155	COG1216	Glycosyl transferase, family 2
BO993_RS04155	COG0438	transferase activity, transferring glycosyl groups
BO993_RS04175	COG0626	cystathionine gamma-synthase activity
BO993_RS04205	COG0625	glutathione transferase activity
BO993_RS04220	COG0513	Belongs to the DEAD box helicase family
BO993_RS04230	COG0720	synthase
BO993_RS04240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BO993_RS04245	COG1956	GAF domain-containing protein
BO993_RS04285	COG0339	signal peptide processing
BO993_RS04335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BO993_RS04340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO993_RS04390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BO993_RS04395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BO993_RS04400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BO993_RS04405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BO993_RS04415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BO993_RS04425	COG0356	it plays a direct role in the translocation of protons across the membrane
BO993_RS04445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BO993_RS04455	COG0508	dehydrogenase complex catalyzes the overall conversion of
BO993_RS04485	COG2011	ABC-type metal ion transport system permease component
BO993_RS04495	COG0697	spore germination
BO993_RS04530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BO993_RS04535	COG1187	pseudouridine synthase activity
BO993_RS04540	COG2813	Specifically methylates the guanine in position
BO993_RS04570	COG2205	protein histidine kinase activity
BO993_RS04570	COG2202	Pas domain
BO993_RS04595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO993_RS04645	COG0745	RESPONSE REGULATOR receiver
BO993_RS04660	COG1404	Belongs to the peptidase S8 family
BO993_RS04675	COG0842	Transport permease protein
BO993_RS04680	COG1131	(ABC) transporter
BO993_RS04685	COG0025	NhaP-type Na H and K H
BO993_RS04700	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BO993_RS04710	COG1573	uracil-dna glycosylase
BO993_RS04720	COG3384	dioxygenase
BO993_RS04735	COG0667	Aldo Keto reductase
BO993_RS04750	COG3590	peptidase
BO993_RS04770	COG0531	amino acid
BO993_RS04785	COG2972	Histidine kinase
BO993_RS04850	COG1271	oxidase subunit
BO993_RS05025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BO993_RS05035	COG1560	Kdo2-lipid A biosynthetic process
BO993_RS05085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BO993_RS05085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BO993_RS05090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BO993_RS05095	COG0242	peptide deformylase activity
BO993_RS05100	COG1652	LysM domain
BO993_RS05105	COG0758	DNA mediated transformation
BO993_RS05110	COG2922	Belongs to the Smg family
BO993_RS05125	COG1754	DNA topoisomerase type I activity
BO993_RS05125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BO993_RS05130	COG0009	L-threonylcarbamoyladenylate synthase
BO993_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS05155	COG0616	signal peptide processing
BO993_RS05160	COG0534	Mate efflux family protein
BO993_RS05190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BO993_RS05230	COG1324	tolerance protein
BO993_RS05250	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BO993_RS05255	COG0511	ligase activity, forming carbon-carbon bonds
BO993_RS05265	COG0439	Biotin carboxylase
BO993_RS05320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BO993_RS05340	COG2267	carboxylic ester hydrolase activity
BO993_RS05350	COG2267	carboxylic ester hydrolase activity
BO993_RS05355	COG3039	Transposase
BO993_RS05365	COG0138	bifunctional purine biosynthesis protein purh
BO993_RS05375	COG0151	Belongs to the GarS family
BO993_RS05400	COG1289	transmembrane transporter activity
BO993_RS05415	COG2814	Major facilitator Superfamily
BO993_RS05440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BO993_RS05475	COG0745	RESPONSE REGULATOR receiver
BO993_RS05520	COG0739	heme binding
BO993_RS05540	COG2211	Major facilitator Superfamily
BO993_RS05545	COG0708	Exodeoxyribonuclease III
BO993_RS05560	COG1192	Involved in chromosome partitioning
BO993_RS05565	COG1475	DNA binding
BO993_RS05580	COG0463	Glycosyl transferase, family 2
BO993_RS05605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BO993_RS05630	COG4221	oxidoreductase activity
BO993_RS05655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BO993_RS05660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BO993_RS05680	COG3485	protocatechuate 3,4-dioxygenase
BO993_RS05720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BO993_RS05730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BO993_RS05745	COG0045	succinate-CoA ligase (ADP-forming) activity
BO993_RS05745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BO993_RS05745	COG1042	CoA-binding domain protein
BO993_RS05760	COG2239	Acts as a magnesium transporter
BO993_RS05780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BO993_RS05800	COG3100	YcgL domain-containing protein
BO993_RS05805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BO993_RS05815	COG0463	Glycosyl transferase, family 2
BO993_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS05845	COG0156	8-amino-7-oxononanoate synthase activity
BO993_RS05850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BO993_RS05855	COG1040	competence protein
BO993_RS05860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BO993_RS05875	COG0628	permease
BO993_RS05885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BO993_RS05900	COG0753	catalase activity
BO993_RS05950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BO993_RS05955	COG0180	Tryptophanyl-tRNA synthetase
BO993_RS05960	COG3237	CsbD-like
BO993_RS06000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BO993_RS06015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BO993_RS06020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BO993_RS06020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BO993_RS06060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BO993_RS06090	COG1566	PFAM secretion protein HlyD family protein
BO993_RS06110	COG1199	ATP-dependent helicase activity
BO993_RS06145	COG0583	DNA-binding transcription factor activity
BO993_RS06195	COG0625	glutathione transferase activity
BO993_RS06230	COG4555	ABC transporter
BO993_RS06240	COG1476	TRANSCRIPTIONal
BO993_RS06265	COG1131	(ABC) transporter
BO993_RS06270	COG0842	Transport permease protein
BO993_RS06280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BO993_RS06365	COG1181	Belongs to the D-alanine--D-alanine ligase family
BO993_RS06380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BO993_RS06390	COG0564	pseudouridine synthase activity
BO993_RS06420	COG0339	signal peptide processing
BO993_RS06450	COG3254	rhamnose metabolic process
BO993_RS06455	COG0738	Major facilitator superfamily
BO993_RS06460	COG1414	Transcriptional regulator
BO993_RS06470	COG2205	protein histidine kinase activity
BO993_RS06480	COG3459	Glycosyltransferase 36 associated
BO993_RS06485	COG2211	Major facilitator Superfamily
BO993_RS06490	COG3265	gluconokinase activity
BO993_RS06510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO993_RS06590	COG1127	ABC transporter
BO993_RS06595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BO993_RS06600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BO993_RS06615	COG2853	Lipoprotein
BO993_RS06645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BO993_RS06710	COG0676	glucose-6-phosphate 1-epimerase activity
BO993_RS06730	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO993_RS06740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO993_RS06750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO993_RS06760	COG1064	alcohol dehydrogenase
BO993_RS06810	COG1522	sequence-specific DNA binding
BO993_RS06815	COG3186	Phenylalanine-4-hydroxylase
BO993_RS06830	COG2755	lipolytic protein G-D-S-L family
BO993_RS06860	COG2937	Belongs to the GPAT DAPAT family
BO993_RS06895	COG0284	orotidine-5'-phosphate decarboxylase activity
BO993_RS06900	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BO993_RS06905	COG3132	Protein of unknown function, DUF480
BO993_RS06920	COG0210	DNA helicase
BO993_RS06935	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BO993_RS06960	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS06985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BO993_RS07050	COG1166	arginine decarboxylase activity
BO993_RS07055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BO993_RS07100	COG0606	chelatase, subunit chli
BO993_RS07160	COG0366	Alpha amylase catalytic
BO993_RS07165	COG0366	Alpha amylase catalytic
BO993_RS07195	COG1609	Transcriptional regulator
BO993_RS07245	COG0493	'glutamate synthase
BO993_RS07250	COG0070	glutamate synthase
BO993_RS07250	COG0069	glutamate synthase activity
BO993_RS07250	COG0067	glutamate synthase
BO993_RS07310	COG1205	dead DEAH box helicase
BO993_RS07310	COG1111	helicase
BO993_RS07315	COG1272	protein, Hemolysin III
BO993_RS07360	COG1136	(ABC) transporter
BO993_RS07405	COG1136	(ABC) transporter
BO993_RS07455	COG3039	Transposase
BO993_RS07465	COG0513	Belongs to the DEAD box helicase family
BO993_RS07550	COG1858	cytochrome C peroxidase
BO993_RS07565	COG0702	epimerase
BO993_RS07590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BO993_RS07610	COG1649	PFAM Uncharacterised BCR, COG1649
BO993_RS07615	COG2354	Protein conserved in bacteria
BO993_RS07625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BO993_RS07640	COG3264	Mechanosensitive ion channel
BO993_RS07640	COG1511	domain protein
BO993_RS07720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BO993_RS07825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BO993_RS07835	COG0642	Histidine kinase
BO993_RS07845	COG1090	epimerase
BO993_RS07855	COG3039	Transposase
BO993_RS07880	COG2826	transposase and inactivated derivatives, IS30 family
BO993_RS07970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO993_RS07985	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BO993_RS08005	COG1304	FMN binding
BO993_RS08010	COG3039	Transposase
BO993_RS08025	COG4772	TonB-dependent receptor
BO993_RS08035	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BO993_RS08045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BO993_RS08055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BO993_RS08085	COG0501	Belongs to the peptidase M48B family
BO993_RS08095	COG0187	DNA topoisomerase II activity
BO993_RS08115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BO993_RS08140	COG0726	polysaccharide deacetylase
BO993_RS08145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BO993_RS08150	COG0671	phosphoesterase, PA-phosphatase related
BO993_RS08160	COG0584	glycerophosphoryl diester phosphodiesterase
BO993_RS08175	COG0861	Integral membrane protein TerC family
BO993_RS08185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BO993_RS08200	COG2271	Major facilitator Superfamily
BO993_RS08205	COG1929	Belongs to the glycerate kinase type-1 family
BO993_RS08280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BO993_RS08290	COG0477	Major facilitator Superfamily
BO993_RS08310	COG0302	gtp cyclohydrolase
BO993_RS08315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BO993_RS08365	COG2234	aminopeptidase activity
BO993_RS08375	COG4942	peptidase
BO993_RS08380	COG0793	Belongs to the peptidase S41A family
BO993_RS08440	COG0386	Belongs to the glutathione peroxidase family
BO993_RS08450	COG1322	Protein conserved in bacteria
BO993_RS08460	COG0531	amino acid
BO993_RS08475	COG0210	DNA helicase
BO993_RS08495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BO993_RS08500	COG0583	DNA-binding transcription factor activity
BO993_RS08505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BO993_RS08520	COG2159	amidohydrolase
BO993_RS08545	COG0357	Ribosomal RNA small subunit methyltransferase G
BO993_RS08550	COG3540	Alkaline phosphatase
BO993_RS08560	COG2091	lysine biosynthetic process via aminoadipic acid
BO993_RS08575	COG0708	Exodeoxyribonuclease III
BO993_RS08590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BO993_RS08595	COG3162	membrane
BO993_RS08635	COG3507	Belongs to the glycosyl hydrolase 43 family
BO993_RS08655	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS08660	COG0179	Fumarylacetoacetate (FAA) hydrolase
BO993_RS08670	COG4948	Mandelate Racemase Muconate Lactonizing
BO993_RS08675	COG4807	Protein conserved in bacteria
BO993_RS08680	COG1643	Atp-dependent helicase
BO993_RS08695	COG1187	pseudouridine synthase activity
BO993_RS08705	COG0667	Aldo Keto reductase
BO993_RS08710	COG2130	NADP-dependent
BO993_RS08715	COG0656	L-ascorbic acid biosynthetic process
BO993_RS08740	COG3039	Transposase
BO993_RS08755	COG1752	Esterase of the alpha-beta hydrolase superfamily
BO993_RS08765	COG1119	ATPase activity
BO993_RS08780	COG0517	IMP dehydrogenase activity
BO993_RS08780	COG1125	glycine betaine transport
BO993_RS08795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BO993_RS08800	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BO993_RS08805	COG3550	peptidyl-serine autophosphorylation
BO993_RS08810	COG1396	sequence-specific DNA binding
BO993_RS08830	COG0489	protein tyrosine kinase activity
BO993_RS08835	COG2062	phosphohistidine phosphatase, SixA
BO993_RS08845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BO993_RS08890	COG1968	undecaprenyl-diphosphatase activity
BO993_RS08895	COG0174	glutamine synthetase
BO993_RS08900	COG0347	Belongs to the P(II) protein family
BO993_RS08905	COG0004	ammonium transporteR
BO993_RS08910	COG3852	Histidine kinase
BO993_RS08915	COG2204	response regulator
BO993_RS08920	COG2032	superoxide dismutase activity
BO993_RS08925	COG2032	superoxide dismutase activity
BO993_RS08970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BO993_RS08975	COG1074	ATP-dependent DNA helicase activity
BO993_RS08985	COG3549	Plasmid maintenance system killer
BO993_RS09075	COG1764	response to oxidative stress
BO993_RS09080	COG1846	Transcriptional regulator
BO993_RS09120	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BO993_RS09170	COG2211	Major facilitator Superfamily
BO993_RS09195	COG3693	PFAM glycoside hydrolase, family 10
BO993_RS09220	COG0246	Mannitol dehydrogenase
BO993_RS09225	COG1472	Belongs to the glycosyl hydrolase 3 family
BO993_RS09235	COG4948	Mandelate Racemase Muconate Lactonizing
BO993_RS09245	COG3661	Belongs to the glycosyl hydrolase 67 family
BO993_RS09265	COG0037	tRNA processing
BO993_RS09270	COG2974	May be involved in recombination
BO993_RS09295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BO993_RS09305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BO993_RS09315	COG0805	protein transport
BO993_RS09325	COG0519	Catalyzes the synthesis of GMP from XMP
BO993_RS09325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BO993_RS09350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BO993_RS09355	COG0752	glycyl-tRNA synthetase alpha subunit
BO993_RS09365	COG0457	Tetratricopeptide repeat
BO993_RS09370	COG4771	TonB-dependent receptor
BO993_RS09385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BO993_RS09395	COG0697	spore germination
BO993_RS09405	COG0523	cobalamin synthesis protein
BO993_RS09460	COG1960	acyl-CoA dehydrogenase activity
BO993_RS09465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BO993_RS09470	COG4770	biotin carboxylase activity
BO993_RS09535	COG2072	flavoprotein involved in K transport
BO993_RS09555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BO993_RS09600	COG0084	hydrolase, TatD family'
BO993_RS09620	COG0583	DNA-binding transcription factor activity
BO993_RS09625	COG2814	Major facilitator Superfamily
BO993_RS09635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BO993_RS09640	COG1902	pentaerythritol trinitrate reductase activity
BO993_RS09670	COG0745	RESPONSE REGULATOR receiver
BO993_RS09690	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BO993_RS09695	COG0583	DNA-binding transcription factor activity
BO993_RS09725	COG0702	epimerase
BO993_RS09730	COG1733	regulation of RNA biosynthetic process
BO993_RS09790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BO993_RS09805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BO993_RS09840	COG2911	Protein conserved in bacteria
BO993_RS09845	COG0729	surface antigen
BO993_RS09860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BO993_RS09865	COG3118	belongs to the thioredoxin family
BO993_RS09875	COG2884	Cell division ATP-binding protein ftsE
BO993_RS09880	COG2177	Part of the ABC transporter FtsEX involved in
BO993_RS09885	COG3437	response regulator, receiver
BO993_RS09890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BO993_RS09895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BO993_RS09905	COG1252	NADH dehydrogenase
BO993_RS09930	COG0459	protein refolding
BO993_RS09940	COG4771	TonB-dependent receptor
BO993_RS09955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BO993_RS09995	COG3386	PFAM SMP-30 Gluconolaconase
BO993_RS10010	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BO993_RS10050	COG0778	Nitroreductase
BO993_RS10055	COG2353	YceI-like domain
BO993_RS10115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BO993_RS10165	COG0408	coproporphyrinogen oxidase activity
BO993_RS10175	COG3039	Transposase
BO993_RS10200	COG0129	dihydroxy-acid dehydratase activity
BO993_RS10210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BO993_RS10265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BO993_RS10270	COG0318	PFAM AMP-dependent synthetase and ligase
BO993_RS10275	COG0727	PFAM Uncharacterised protein family (UPF0153)
BO993_RS10280	COG0596	Alpha beta hydrolase
BO993_RS10295	COG3177	Filamentation induced by cAMP protein fic
BO993_RS10300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BO993_RS10315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BO993_RS10340	COG4191	Histidine kinase
BO993_RS10345	COG0028	Belongs to the TPP enzyme family
BO993_RS10360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BO993_RS10365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BO993_RS10405	COG5383	Protein conserved in bacteria
BO993_RS10420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO993_RS10425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO993_RS10430	COG1473	amidohydrolase
BO993_RS10440	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BO993_RS10440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BO993_RS10475	COG3039	Transposase
BO993_RS10495	COG3039	Transposase
BO993_RS10575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BO993_RS10580	COG0134	indole-3-glycerol-phosphate synthase activity
BO993_RS10590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BO993_RS10595	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BO993_RS10605	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BO993_RS10610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BO993_RS10615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BO993_RS10665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BO993_RS10680	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BO993_RS10745	COG0358	DNA primase activity
BO993_RS10750	COG1295	ribonuclease BN
BO993_RS10765	COG1610	YqeY-like protein
BO993_RS10775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BO993_RS10780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BO993_RS10820	COG2133	pyrroloquinoline quinone binding
BO993_RS10825	COG4682	membrane
BO993_RS10850	COG0531	amino acid
BO993_RS10885	COG4948	Mandelate Racemase Muconate Lactonizing
BO993_RS10895	COG3023	N-Acetylmuramoyl-L-alanine amidase
BO993_RS10900	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BO993_RS10975	COG0183	Belongs to the thiolase family
BO993_RS11015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BO993_RS11025	COG3483	tryptophan 2,3-dioxygenase activity
BO993_RS11030	COG3104	oligopeptide transport
BO993_RS11050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BO993_RS11060	COG1320	monovalent cation:proton antiporter activity
BO993_RS11065	COG2212	antiporter activity
BO993_RS11075	COG0651	ATP synthesis coupled electron transport
BO993_RS11080	COG1006	Multisubunit Na H antiporter MnhC subunit
BO993_RS11085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BO993_RS11085	COG2111	Na H antiporter
BO993_RS11130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BO993_RS11140	COG0456	acetyltransferase
BO993_RS11170	COG4221	oxidoreductase activity
BO993_RS11230	COG0697	spore germination
BO993_RS11235	COG4305	rare lipoprotein A
BO993_RS11240	COG5297	Belongs to the glycosyl hydrolase family 6
BO993_RS11250	COG1113	amino acid transport
BO993_RS11260	COG0598	Magnesium transport protein CorA
BO993_RS11345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BO993_RS11345	COG5297	Belongs to the glycosyl hydrolase family 6
BO993_RS11350	COG0659	secondary active sulfate transmembrane transporter activity
BO993_RS11395	COG3275	phosphorelay sensor kinase activity
BO993_RS11405	COG0181	hydroxymethylbilane synthase activity
BO993_RS11430	COG1505	serine-type exopeptidase activity
BO993_RS11465	COG0436	Aminotransferase
BO993_RS11495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BO993_RS11525	COG0308	aminopeptidase N
BO993_RS11530	COG2199	diguanylate cyclase activity
BO993_RS11580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO993_RS11585	COG1077	Cell shape determining protein MreB Mrl
BO993_RS11590	COG1792	Involved in formation and maintenance of cell shape
BO993_RS11605	COG0772	Belongs to the SEDS family
BO993_RS11680	COG2951	lytic endotransglycosylase activity
BO993_RS11685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BO993_RS11690	COG1686	Belongs to the peptidase S11 family
BO993_RS11705	COG2921	Belongs to the UPF0250 family
BO993_RS11730	COG1056	cytidyltransferase-related domain
BO993_RS11730	COG1051	belongs to the nudix hydrolase family
BO993_RS11765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BO993_RS11770	COG0673	inositol 2-dehydrogenase activity
BO993_RS11775	COG2823	Periplasmic or secreted lipoprotein
BO993_RS11780	COG4251	negative regulation of phosphorylation
BO993_RS11785	COG0784	Response regulator, receiver
BO993_RS11790	COG4191	Histidine kinase
BO993_RS11795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BO993_RS11845	COG3250	beta-galactosidase activity
BO993_RS11860	COG2188	Transcriptional regulator
BO993_RS11870	COG1609	Transcriptional regulator
BO993_RS11875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BO993_RS11880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BO993_RS11890	COG1215	transferase activity, transferring glycosyl groups
BO993_RS11895	COG1649	PFAM Uncharacterised BCR, COG1649
BO993_RS11895	COG0726	polysaccharide deacetylase
BO993_RS12000	COG3039	Transposase
BO993_RS12035	COG3039	Transposase
BO993_RS12070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BO993_RS12085	COG2205	protein histidine kinase activity
BO993_RS12140	COG2205	protein histidine kinase activity
BO993_RS12190	COG3039	Transposase
BO993_RS12200	COG0488	(ABC) transporter
BO993_RS12220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BO993_RS12240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BO993_RS12240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BO993_RS12260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BO993_RS12265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BO993_RS12270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BO993_RS12295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BO993_RS12300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BO993_RS12310	COG2205	protein histidine kinase activity
BO993_RS12315	COG0745	RESPONSE REGULATOR receiver
BO993_RS12320	COG0277	FAD linked oxidase domain protein
BO993_RS12325	COG1988	membrane-bound metal-dependent
BO993_RS12330	COG0792	nuclease activity
BO993_RS12365	COG0275	rRNA processing
BO993_RS12370	COG3116	cell division
BO993_RS12385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BO993_RS12390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BO993_RS12405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BO993_RS12410	COG1181	Belongs to the D-alanine--D-alanine ligase family
BO993_RS12415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BO993_RS12430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BO993_RS12440	COG1388	LysM domain
BO993_RS12440	COG4942	peptidase
BO993_RS12455	COG0494	nUDIX hydrolase
BO993_RS12470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BO993_RS12485	COG0604	alcohol dehydrogenase
BO993_RS12485	COG3321	synthase
BO993_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS12540	COG2226	methyltransferase
BO993_RS12545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BO993_RS12600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BO993_RS12615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BO993_RS12630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO993_RS12635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BO993_RS12645	COG3039	Transposase
BO993_RS12655	COG0667	Aldo Keto reductase
BO993_RS12710	COG2175	clavaminate synthase activity
BO993_RS12720	COG4181	ATPase activity
BO993_RS12735	COG0642	Histidine kinase
BO993_RS12755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BO993_RS12775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BO993_RS12800	COG2967	ApaG domain
BO993_RS12805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BO993_RS12815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BO993_RS12830	COG0123	including yeast histone deacetylase and acetoin utilization protein
BO993_RS12835	COG2096	Adenosyltransferase
BO993_RS12845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BO993_RS12850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BO993_RS12890	COG0583	DNA-binding transcription factor activity
BO993_RS12895	COG0318	PFAM AMP-dependent synthetase and ligase
BO993_RS12905	COG1024	Enoyl-CoA hydratase
BO993_RS12925	COG3386	PFAM SMP-30 Gluconolaconase
BO993_RS12955	COG0697	spore germination
BO993_RS13055	COG1902	pentaerythritol trinitrate reductase activity
BO993_RS13055	COG0446	pyridine nucleotide-disulphide oxidoreductase
BO993_RS13060	COG0604	alcohol dehydrogenase
BO993_RS13090	COG0156	8-amino-7-oxononanoate synthase activity
BO993_RS13095	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BO993_RS13100	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BO993_RS13105	COG4208	sulfate ABC transporter
BO993_RS13110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BO993_RS13145	COG0588	phosphoglycerate mutase activity
BO993_RS13155	COG0285	dihydrofolate synthase activity
BO993_RS13175	COG2833	Protein of unknown function (DUF455)
BO993_RS13195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BO993_RS13200	COG0671	phosphoesterase, PA-phosphatase related
BO993_RS13205	COG0438	transferase activity, transferring glycosyl groups
BO993_RS13215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BO993_RS13230	COG4783	chaperone-mediated protein folding
BO993_RS13255	COG0473	3-isopropylmalate dehydrogenase activity
BO993_RS13310	COG0544	peptidyl-prolyl cis-trans isomerase activity
BO993_RS13350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BO993_RS13375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BO993_RS13385	COG0631	protein serine/threonine phosphatase activity
BO993_RS13440	COG0582	viral genome integration into host DNA
BO993_RS13450	COG0859	PFAM glycosyl transferase family 9
BO993_RS13455	COG3642	lipopolysaccharide core region biosynthetic process
BO993_RS13460	COG1234	tRNA 3'-trailer cleavage
BO993_RS13465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BO993_RS13475	COG0315	cyclic pyranopterin monophosphate synthase activity
BO993_RS13480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BO993_RS13485	COG0314	molybdopterin synthase activity
BO993_RS13515	COG0537	adenosine 5'-monophosphoramidase activity
BO993_RS13535	COG0714	Associated with various cellular activities
BO993_RS13555	COG0242	peptide deformylase activity
BO993_RS13605	COG3039	Transposase
BO993_RS13645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BO993_RS13650	COG0726	polysaccharide deacetylase
BO993_RS13675	COG1162	GTPase activity
BO993_RS13700	COG2211	Major facilitator Superfamily
BO993_RS13710	COG1609	Transcriptional regulator
BO993_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS13720	COG2851	Citrate transporter
BO993_RS13740	COG0642	Histidine kinase
BO993_RS13750	COG2197	response regulator
BO993_RS13770	COG0583	DNA-binding transcription factor activity
BO993_RS13785	COG4191	Histidine kinase
BO993_RS13805	COG0280	phosphate acetyltransferase
BO993_RS13805	COG0281	malic enzyme
BO993_RS13875	COG0352	thiamine-phosphate diphosphorylase activity
BO993_RS13880	COG1773	rubredoxin
BO993_RS13885	COG2912	Transglutaminase-like superfamily
BO993_RS13895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BO993_RS13905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BO993_RS13930	COG0006	proline dipeptidase activity
BO993_RS13960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BO993_RS13975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BO993_RS13980	COG1561	YicC-like family, N-terminal region
BO993_RS14005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BO993_RS14015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BO993_RS14040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BO993_RS14085	COG0714	Associated with various cellular activities
BO993_RS14105	COG2304	oxidoreductase activity
BO993_RS14125	COG1301	dicarboxylic acid transport
BO993_RS14130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BO993_RS14140	COG0739	heme binding
BO993_RS14145	COG1376	ErfK ybiS ycfS ynhG family protein
BO993_RS14170	COG1022	Amp-dependent synthetase and ligase
BO993_RS14180	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS14195	COG0642	Histidine kinase
BO993_RS14215	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BO993_RS14220	COG4149	molybdate abc transporter
BO993_RS14225	COG0725	ABC transporter, periplasmic molybdate-binding protein
BO993_RS14230	COG3453	Protein conserved in bacteria
BO993_RS14230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BO993_RS14260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BO993_RS14280	COG2205	protein histidine kinase activity
BO993_RS14285	COG0745	RESPONSE REGULATOR receiver
BO993_RS14300	COG3039	Transposase
BO993_RS14335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BO993_RS14340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BO993_RS14390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BO993_RS14410	COG2801	Transposase and inactivated derivatives
BO993_RS14500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BO993_RS14510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BO993_RS14515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BO993_RS14530	COG1842	Phage shock protein A
BO993_RS14555	COG0754	glutathionylspermidine amidase activity
BO993_RS14625	COG0531	amino acid
BO993_RS14630	COG2197	response regulator
BO993_RS14645	COG1113	amino acid transport
BO993_RS14665	COG1271	oxidase subunit
BO993_RS14670	COG1294	oxidase, subunit
BO993_RS14680	COG2239	Acts as a magnesium transporter
BO993_RS14690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BO993_RS14695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BO993_RS14705	COG1660	Displays ATPase and GTPase activities
BO993_RS14710	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BO993_RS14715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BO993_RS14730	COG1137	ATPase activity
BO993_RS14735	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BO993_RS14745	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BO993_RS14755	COG0271	Belongs to the BolA IbaG family
BO993_RS14760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BO993_RS14780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BO993_RS14795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BO993_RS14805	COG0628	permease
BO993_RS14815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BO993_RS14820	COG3178	'Phosphotransferase
BO993_RS14835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BO993_RS14840	COG1555	photosystem II stabilization
BO993_RS14885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BO993_RS14895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BO993_RS14920	COG0228	four-way junction DNA binding
BO993_RS14925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BO993_RS14930	COG0336	Belongs to the RNA methyltransferase TrmD family
BO993_RS14945	COG0534	Mate efflux family protein
BO993_RS14995	COG0542	response to heat
BO993_RS15035	COG4206	TonB-dependent receptor
BO993_RS15095	COG0019	diaminopimelate decarboxylase activity
BO993_RS15105	COG2814	Major facilitator Superfamily
BO993_RS15110	COG4264	IucA IucC family
BO993_RS15120	COG4772	TonB-dependent receptor
BO993_RS15135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BO993_RS15135	COG4651	solute:proton antiporter activity
BO993_RS15170	COG0488	(ABC) transporter
BO993_RS15195	COG0657	acetylesterase activity
BO993_RS15195	COG2755	lipolytic protein G-D-S-L family
BO993_RS15220	COG2207	Transcriptional regulator
BO993_RS15225	COG0326	Molecular chaperone. Has ATPase activity
BO993_RS15260	COG0174	glutamine synthetase
BO993_RS15265	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BO993_RS15275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BO993_RS15290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BO993_RS15315	COG2146	nitrite reductase [NAD(P)H] activity
BO993_RS15330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BO993_RS15335	COG0719	Fe-S assembly protein
BO993_RS15340	COG0396	ATPase activity
BO993_RS15345	COG0719	Fe-S assembly protein
BO993_RS15350	COG1959	2 iron, 2 sulfur cluster binding
BO993_RS15370	COG0693	protein deglycase activity
BO993_RS15415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BO993_RS15450	COG0519	Catalyzes the synthesis of GMP from XMP
BO993_RS15460	COG1678	Uncharacterized ACR, COG1678
BO993_RS15465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BO993_RS15480	COG1764	response to oxidative stress
BO993_RS15490	COG0384	phenazine biosynthesis protein PhzF
BO993_RS15500	COG0527	aspartate kinase activity
BO993_RS15530	COG0142	geranyltranstransferase activity
BO993_RS15535	COG0629	single-stranded DNA binding
BO993_RS15540	COG5001	Diguanylate cyclase
BO993_RS15540	COG2203	Gaf domain
BO993_RS15540	COG3706	GGDEF domain
BO993_RS15540	COG4251	negative regulation of phosphorylation
BO993_RS15585	COG2879	small protein
BO993_RS15590	COG1966	Carbon starvation protein
BO993_RS15595	COG1741	Belongs to the pirin family
BO993_RS15665	COG1741	Belongs to the pirin family
BO993_RS15675	COG1515	deoxyribonuclease V activity
BO993_RS15680	COG0588	phosphoglycerate mutase activity
BO993_RS15695	COG3590	peptidase
BO993_RS15710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BO993_RS15715	COG2200	EAL domain
BO993_RS15715	COG2202	Pas domain
BO993_RS15715	COG2199	diguanylate cyclase activity
BO993_RS15720	COG0835	chemotaxis
BO993_RS15725	COG0840	transmembrane signaling receptor activity
BO993_RS15735	COG0643	Histidine kinase
BO993_RS15735	COG2198	Histidine kinase
BO993_RS15750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BO993_RS15760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BO993_RS15780	COG2205	protein histidine kinase activity
BO993_RS15830	COG3039	Transposase
BO993_RS15870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BO993_RS15875	COG0735	belongs to the Fur family
BO993_RS15935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BO993_RS15940	COG0084	hydrolase, TatD family'
BO993_RS15955	COG1960	acyl-CoA dehydrogenase activity
BO993_RS15970	COG0367	asparagine synthase
BO993_RS15980	COG0305	Participates in initiation and elongation during chromosome replication
BO993_RS15985	COG0415	Belongs to the DNA photolyase family
BO993_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS16110	COG5001	Diguanylate cyclase
BO993_RS16110	COG5002	protein histidine kinase activity
BO993_RS16115	COG1187	pseudouridine synthase activity
BO993_RS16140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BO993_RS16150	COG0475	glutathione-regulated potassium exporter activity
BO993_RS16155	COG5002	protein histidine kinase activity
BO993_RS16155	COG5000	phosphorelay sensor kinase activity
BO993_RS16160	COG0745	RESPONSE REGULATOR receiver
BO993_RS16190	COG1132	(ABC) transporter
BO993_RS16225	COG3039	Transposase
BO993_RS16245	COG3039	Transposase
BO993_RS16270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BO993_RS16280	COG4969	Belongs to the N-Me-Phe pilin family
BO993_RS16285	COG2194	sulfuric ester hydrolase activity
BO993_RS16325	COG0045	succinate-CoA ligase (ADP-forming) activity
BO993_RS16330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BO993_RS16340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BO993_RS16340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BO993_RS16345	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO993_RS16350	COG0564	pseudouridine synthase activity
BO993_RS16375	COG3387	PFAM Glycoside hydrolase 15-related
BO993_RS16380	COG1877	trehalose-phosphatase activity
BO993_RS16420	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BO993_RS16435	COG1595	DNA-templated transcription, initiation
BO993_RS16445	COG1946	Acyl-CoA thioesterase
BO993_RS16460	COG0824	Thioesterase
BO993_RS16465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BO993_RS16475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BO993_RS16480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BO993_RS16485	COG0268	Binds directly to 16S ribosomal RNA
BO993_RS16490	COG0728	peptidoglycan biosynthetic process
BO993_RS16495	COG0196	riboflavin kinase activity
BO993_RS16505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BO993_RS16510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BO993_RS16525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BO993_RS16530	COG1845	cytochrome c oxidase, subunit III
BO993_RS16535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BO993_RS16580	COG3209	COG3209 Rhs family protein
BO993_RS16730	COG0632	four-way junction helicase activity
BO993_RS16740	COG2255	four-way junction helicase activity
BO993_RS16745	COG0824	Thioesterase
BO993_RS16755	COG0848	biopolymer transport protein
BO993_RS16770	COG2885	chlorophyll binding
BO993_RS16780	COG0602	queuosine metabolic process
BO993_RS16790	COG1187	pseudouridine synthase activity
BO993_RS16850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BO993_RS16875	COG0514	ATP-dependent DNA helicase (RecQ)
BO993_RS16885	COG0783	Belongs to the Dps family
BO993_RS16890	COG1643	Atp-dependent helicase
BO993_RS16915	COG0535	radical SAM domain protein
BO993_RS16920	COG0535	radical SAM domain protein
BO993_RS16940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BO993_RS16950	COG1215	transferase activity, transferring glycosyl groups
BO993_RS16955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BO993_RS16965	COG1199	ATP-dependent helicase activity
BO993_RS16975	COG1397	ADP-ribosylglycohydrolase
BO993_RS16985	COG0189	ligase activity
BO993_RS17000	COG0835	chemotaxis
BO993_RS17005	COG0840	transmembrane signaling receptor activity
BO993_RS17010	COG0643	Histidine kinase
BO993_RS17010	COG0784	Response regulator, receiver
BO993_RS17010	COG2198	Histidine kinase
BO993_RS17035	COG3039	Transposase
BO993_RS17070	COG1446	asparaginase
BO993_RS17075	COG3142	Participates in the control of copper homeostasis
BO993_RS17125	COG3537	Alpha-1,2-mannosidase
BO993_RS17175	COG1472	Belongs to the glycosyl hydrolase 3 family
BO993_RS17195	COG1388	LysM domain
BO993_RS17195	COG3858	chitin binding
BO993_RS17210	COG0837	glucose binding
BO993_RS17215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BO993_RS17225	COG0494	nUDIX hydrolase
BO993_RS17235	COG3956	TIGRFAM MazG family protein
BO993_RS17250	COG0330	HflC and HflK could
BO993_RS17265	COG0509	glycine decarboxylation via glycine cleavage system
BO993_RS17300	COG1960	acyl-CoA dehydrogenase activity
BO993_RS17310	COG1309	transcriptional regulator
BO993_RS17315	COG4771	TonB-dependent receptor
BO993_RS17325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BO993_RS17335	COG0463	Glycosyl transferase, family 2
BO993_RS17355	COG1272	protein, Hemolysin III
BO993_RS17365	COG0739	heme binding
BO993_RS17370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BO993_RS17375	COG0626	cystathionine gamma-synthase activity
BO993_RS17385	COG1760	l-serine dehydratase
BO993_RS17400	COG2353	YceI-like domain
BO993_RS17410	COG2353	YceI-like domain
BO993_RS17480	COG1960	acyl-CoA dehydrogenase activity
BO993_RS17485	COG1024	Enoyl-CoA hydratase
BO993_RS17505	COG1024	Enoyl-CoA hydratase
BO993_RS17505	COG1250	3-hydroxyacyl-CoA dehydrogenase
BO993_RS17520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BO993_RS17550	COG1381	Involved in DNA repair and RecF pathway recombination
BO993_RS17565	COG2954	triphosphatase activity
BO993_RS17575	COG3039	Transposase
BO993_RS17610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BO993_RS17620	COG3046	protein related to deoxyribodipyrimidine photolyase
BO993_RS17630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BO993_RS17635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BO993_RS17640	COG1278	Cold shock
BO993_RS17660	COG1201	RNA secondary structure unwinding
BO993_RS17665	COG1793	dna ligase
BO993_RS17675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BO993_RS17675	COG1793	dna ligase
BO993_RS17705	COG0183	Belongs to the thiolase family
BO993_RS17730	COG1451	nucleotide metabolic process
BO993_RS17745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BO993_RS17750	COG3039	Transposase
BO993_RS17800	COG1047	Peptidyl-prolyl cis-trans
BO993_RS17815	COG2824	Alkylphosphonate utilization operon protein PhnA
BO993_RS17830	COG1902	pentaerythritol trinitrate reductase activity
BO993_RS17835	COG2814	Major facilitator Superfamily
BO993_RS17870	COG3039	Transposase
BO993_RS17900	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BO993_RS17900	COG0392	lysyltransferase activity
BO993_RS17910	COG0251	oxidation-reduction process
BO993_RS17915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BO993_RS17930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BO993_RS17955	COG1595	DNA-templated transcription, initiation
BO993_RS17975	COG2878	Part of a membrane complex involved in electron transport
BO993_RS17985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BO993_RS17985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BO993_RS18005	COG0833	amino acid
BO993_RS18010	COG2040	homocysteine
BO993_RS18025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BO993_RS18060	COG2895	sulfate adenylyltransferase (ATP) activity
BO993_RS18060	COG0529	Catalyzes the synthesis of activated sulfate
BO993_RS18105	COG1981	membrane
BO993_RS18130	COG1131	(ABC) transporter
BO993_RS18135	COG4771	TonB-dependent receptor
BO993_RS18145	COG0825	malonyl-CoA metabolic process
BO993_RS18165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BO993_RS18170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BO993_RS18190	COG0750	zinc metalloprotease
BO993_RS18200	COG0575	Belongs to the CDS family
BO993_RS18210	COG0233	cytoplasmic translational termination
BO993_RS18225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BO993_RS18275	COG3039	Transposase
BO993_RS18290	COG1393	Belongs to the ArsC family
BO993_RS18305	COG0367	asparagine synthase
BO993_RS18315	COG4774	siderophore transport
BO993_RS18345	COG2207	Transcriptional regulator
BO993_RS18360	COG1566	PFAM secretion protein HlyD family protein
BO993_RS18365	COG2814	Major facilitator Superfamily
BO993_RS18420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BO993_RS18430	COG1960	acyl-CoA dehydrogenase activity
BO993_RS18445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BO993_RS18455	COG2914	Belongs to the UPF0125 (RnfH) family
BO993_RS18465	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO993_RS18475	COG0497	DNA recombination
BO993_RS18485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BO993_RS18490	COG0443	Heat shock 70 kDa protein
BO993_RS18495	COG0484	heat shock protein binding
BO993_RS18505	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BO993_RS18510	COG0287	Prephenate dehydrogenase
BO993_RS18510	COG1605	Chorismate mutase
BO993_RS18530	COG0583	DNA-binding transcription factor activity
BO993_RS18545	COG1132	(ABC) transporter
BO993_RS18580	COG2850	peptidyl-arginine hydroxylation
BO993_RS18645	COG1131	(ABC) transporter
BO993_RS18650	COG1725	Transcriptional regulator
BO993_RS18660	COG0386	Belongs to the glutathione peroxidase family
BO993_RS18675	COG2900	Belongs to the SlyX family
BO993_RS18690	COG1609	Transcriptional regulator
BO993_RS18700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BO993_RS18710	COG1410	methionine synthase
BO993_RS18710	COG0646	methionine synthase
BO993_RS18715	COG1410	methionine synthase
BO993_RS18715	COG0646	methionine synthase
BO993_RS18720	COG2226	methyltransferase
BO993_RS18725	COG1960	acyl-CoA dehydrogenase activity
BO993_RS18755	COG0557	exoribonuclease II activity
BO993_RS18775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BO993_RS18790	COG3039	Transposase
BO993_RS18925	COG0583	DNA-binding transcription factor activity
BO993_RS19020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BO993_RS19025	COG0235	Class ii aldolase
BO993_RS19030	COG0531	amino acid
BO993_RS19035	COG0531	amino acid
BO993_RS19045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BO993_RS19050	COG0277	FAD linked oxidase domain protein
BO993_RS19115	COG0436	Aminotransferase
BO993_RS19140	COG1187	pseudouridine synthase activity
BO993_RS19145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BO993_RS19150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BO993_RS19155	COG2350	Protein conserved in bacteria
BO993_RS19185	COG1175	transmembrane transport
BO993_RS19190	COG0395	ABC-type sugar transport system, permease component
BO993_RS19215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BO993_RS19225	COG2957	Belongs to the agmatine deiminase family
BO993_RS19240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BO993_RS19245	COG0539	negative regulation of cytoplasmic translation
BO993_RS19250	COG0776	regulation of translation
BO993_RS19260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BO993_RS19265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BO993_RS19275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BO993_RS19295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BO993_RS19310	COG3002	Belongs to the UPF0753 family
BO993_RS19315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BO993_RS19320	COG0583	DNA-binding transcription factor activity
BO993_RS19350	COG0583	DNA-binding transcription factor activity
BO993_RS19355	COG0583	DNA-binding transcription factor activity
BO993_RS19385	COG1914	H( )-stimulated, divalent metal cation uptake system
BO993_RS19405	COG0668	transmembrane transport
BO993_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS19435	COG1183	phosphatidylcholine synthase activity
BO993_RS19445	COG3243	poly(R)-hydroxyalkanoic acid synthase
BO993_RS19460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO993_RS19460	COG0723	plastoquinol--plastocyanin reductase activity
BO993_RS19470	COG2183	response to ionizing radiation
BO993_RS19485	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BO993_RS19500	COG0671	phosphoesterase, PA-phosphatase related
BO993_RS19525	COG1794	racemase activity, acting on amino acids and derivatives
BO993_RS19535	COG0697	spore germination
BO993_RS19560	COG1012	belongs to the aldehyde dehydrogenase family
BO993_RS19595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BO993_RS19615	COG0124	histidyl-tRNA synthetase
BO993_RS19635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BO993_RS19650	COG0131	Imidazoleglycerol-phosphate dehydratase
BO993_RS19650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BO993_RS19660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BO993_RS19670	COG0140	phosphoribosyl-ATP diphosphatase activity
BO993_RS19670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BO993_RS19845	COG0653	protein targeting
BO993_RS19915	COG2801	Transposase and inactivated derivatives
BO993_RS19930	COG3039	Transposase
BO993_RS19990	COG0322	excinuclease ABC activity
BO993_RS20000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BO993_RS20010	COG1663	tetraacyldisaccharide 4'-kinase activity
BO993_RS20025	COG0811	peptide transport
BO993_RS20050	COG4591	ABC-type transport system involved in lipoprotein release permease component
BO993_RS20065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BO993_RS20080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BO993_RS20095	COG0354	folic acid binding
BO993_RS20110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BO993_RS20120	COG0363	glucosamine-6-phosphate deaminase activity
BO993_RS20125	COG0129	dihydroxy-acid dehydratase activity
BO993_RS20130	COG0800	Aldolase
BO993_RS20165	COG0784	Response regulator, receiver
BO993_RS20165	COG2205	protein histidine kinase activity
BO993_RS20165	COG5002	protein histidine kinase activity
BO993_RS20180	COG3039	Transposase
BO993_RS20270	COG0386	Belongs to the glutathione peroxidase family
BO993_RS20300	COG1595	DNA-templated transcription, initiation
BO993_RS20360	COG3706	GGDEF domain
BO993_RS20360	COG4251	negative regulation of phosphorylation
BO993_RS20360	COG2203	Gaf domain
BO993_RS20360	COG5001	Diguanylate cyclase
BO993_RS20380	COG1472	Belongs to the glycosyl hydrolase 3 family
BO993_RS20415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BO993_RS20420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BO993_RS20430	COG0617	tRNA 3'-terminal CCA addition
BO993_RS20440	COG1469	GTP cyclohydrolase I activity
BO993_RS20445	COG0860	N-Acetylmuramoyl-L-alanine amidase
BO993_RS20500	COG4566	intracellular signal transduction
BO993_RS20530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BO993_RS20535	COG1605	Chorismate mutase
BO993_RS20535	COG0077	Prephenate dehydratase
BO993_RS20545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BO993_RS20590	COG1228	amidohydrolase
BO993_RS20595	COG2986	histidine ammonia-lyase
BO993_RS20605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BO993_RS20630	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BO993_RS20650	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BO993_RS20665	COG3115	cell septum assembly
BO993_RS20675	COG0359	binds to the 23S rRNA
BO993_RS20685	COG0360	Binds together with S18 to 16S ribosomal RNA
BO993_RS20690	COG0316	Belongs to the HesB IscA family
BO993_RS20725	COG0288	reversible hydration of carbon dioxide
BO993_RS20755	COG2925	Exonuclease
BO993_RS20765	COG0667	Aldo Keto reductase
BO993_RS20790	COG0116	Belongs to the methyltransferase superfamily
BO993_RS20790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BO993_RS20835	COG0494	nUDIX hydrolase
BO993_RS20845	COG1024	Enoyl-CoA hydratase
BO993_RS20855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BO993_RS20900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BO993_RS20905	COG0573	inorganic phosphate transmembrane transporter activity
BO993_RS20920	COG0704	Plays a role in the regulation of phosphate uptake
BO993_RS20930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BO993_RS20970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BO993_RS20975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BO993_RS20980	COG1862	Preprotein translocase
BO993_RS20985	COG0343	queuine tRNA-ribosyltransferase activity
BO993_RS21075	COG3039	Transposase
BO993_RS21100	COG0405	Gamma-glutamyltransferase
BO993_RS21105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BO993_RS21120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BO993_RS21125	COG0742	ribosomal rna small subunit methyltransferase
BO993_RS21185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BO993_RS21240	COG0303	'Molybdopterin
BO993_RS21250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BO993_RS21260	COG1426	Protein conserved in bacteria
BO993_RS21270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BO993_RS21285	COG1024	Enoyl-CoA hydratase
BO993_RS21285	COG1250	3-hydroxyacyl-CoA dehydrogenase
BO993_RS21290	COG0183	Belongs to the thiolase family
BO993_RS21295	COG0038	chloride channel
BO993_RS21315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BO993_RS21340	COG1674	ftsk spoiiie
BO993_RS21345	COG0492	ferredoxin-NADP+ reductase activity
BO993_RS21370	COG0542	response to heat
BO993_RS21385	COG0482	sulfurtransferase activity
BO993_RS21410	COG5001	Diguanylate cyclase
BO993_RS21415	COG4585	Histidine kinase
BO993_RS21425	COG5002	protein histidine kinase activity
BO993_RS21445	COG0784	Response regulator, receiver
BO993_RS21445	COG0835	chemotaxis
BO993_RS21455	COG1558	bacterial-type flagellum-dependent cell motility
BO993_RS21460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BO993_RS21470	COG4787	bacterial-type flagellum-dependent cell motility
BO993_RS21495	COG1705	Flagellar rod assembly protein muramidase FlgJ
BO993_RS21495	COG3951	Flagellar rod assembly protein muramidase FlgJ
BO993_RS21510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BO993_RS21515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BO993_RS21545	COG2201	protein-glutamate methylesterase activity
BO993_RS21565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BO993_RS21575	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS21610	COG1677	Flagellar hook-basal body complex protein FliE
BO993_RS21660	COG3190	flagellar
BO993_RS21680	COG1684	flagellar biosynthetic protein fliR
BO993_RS21735	COG0643	Histidine kinase
BO993_RS21735	COG2198	Histidine kinase
BO993_RS21735	COG0784	Response regulator, receiver
BO993_RS21775	COG3039	Transposase
BO993_RS21785	COG3209	COG3209 Rhs family protein
BO993_RS21810	COG3039	Transposase
BO993_RS21910	COG3039	Transposase
BO993_RS21920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BO993_RS21925	COG4988	ABC transporter
BO993_RS21975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BO993_RS21995	COG0165	Argininosuccinate lyase
BO993_RS22010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BO993_RS22015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BO993_RS22025	COG0137	argininosuccinate synthase activity
BO993_RS22030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BO993_RS22045	COG2166	iron-sulfur cluster assembly
BO993_RS22070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BO993_RS22095	COG4677	pectinesterase activity
BO993_RS22120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BO993_RS22125	COG0402	S-adenosylhomocysteine deaminase activity
BO993_RS22140	COG1509	lysine 2,3-aminomutase activity
BO993_RS22145	COG5001	Diguanylate cyclase
BO993_RS22145	COG3300	MHYT domain
BO993_RS22160	COG0483	inositol monophosphate 1-phosphatase activity
BO993_RS22165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BO993_RS22190	COG0488	(ABC) transporter
BO993_RS22195	COG0513	Belongs to the DEAD box helicase family
BO993_RS22200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BO993_RS22205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BO993_RS22215	COG0625	glutathione transferase activity
BO993_RS22225	COG1671	Belongs to the UPF0178 family
BO993_RS22230	COG4681	YaeQ
BO993_RS22235	COG2081	HI0933 family
BO993_RS22245	COG0501	Belongs to the peptidase M48B family
BO993_RS22255	COG1028	Short-chain dehydrogenase reductase Sdr
BO993_RS22280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BO993_RS22285	COG0860	N-Acetylmuramoyl-L-alanine amidase
BO993_RS22290	COG0802	atpase or kinase
BO993_RS22295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BO993_RS22295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BO993_RS22300	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BO993_RS22320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BO993_RS22450	COG2969	positive regulation of protein catabolic process
BO993_RS22455	COG0625	glutathione transferase activity
BO993_RS22460	COG2857	Cytochrome c1
BO993_RS22465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BO993_RS22470	COG0723	plastoquinol--plastocyanin reductase activity
BO993_RS22480	COG0741	lytic transglycosylase activity
BO993_RS22505	COG1702	phosphate starvation-inducible protein PhoH
BO993_RS22525	COG4535	Mg2 and Co2 transporter CorC
BO993_RS22540	COG1012	belongs to the aldehyde dehydrogenase family
BO993_RS22550	COG1177	transmembrane transport
BO993_RS22560	COG3842	ATPase activity
BO993_RS22600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BO993_RS22605	COG0174	glutamine synthetase
BO993_RS22610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO993_RS22620	COG0477	Major facilitator Superfamily
BO993_RS22630	COG0243	molybdopterin cofactor binding
BO993_RS22640	COG2223	nitrite transmembrane transporter activity
BO993_RS22650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BO993_RS22655	COG1121	(ABC) transporter
BO993_RS22665	COG2733	membrane
BO993_RS22690	COG2902	Dehydrogenase
BO993_RS22700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO993_RS22705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO993_RS22730	COG1609	Transcriptional regulator
BO993_RS22735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BO993_RS22735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BO993_RS22740	COG1105	Belongs to the carbohydrate kinase PfkB family
BO993_RS22745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BO993_RS22745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BO993_RS22785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BO993_RS22995	COG3039	Transposase
BO993_RS23040	COG4771	TonB-dependent receptor
BO993_RS23050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BO993_RS23070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BO993_RS23075	COG1360	Flagellar Motor Protein
BO993_RS23085	COG0835	chemotaxis
BO993_RS23095	COG0745	RESPONSE REGULATOR receiver
BO993_RS23120	COG0840	transmembrane signaling receptor activity
BO993_RS23135	COG0840	transmembrane signaling receptor activity
BO993_RS23145	COG0840	transmembrane signaling receptor activity
BO993_RS23155	COG0840	transmembrane signaling receptor activity
BO993_RS23160	COG0840	transmembrane signaling receptor activity
BO993_RS23165	COG0840	transmembrane signaling receptor activity
BO993_RS23170	COG0840	transmembrane signaling receptor activity
BO993_RS23190	COG0835	chemotaxis
BO993_RS23210	COG3039	Transposase
BO993_RS23230	COG0840	transmembrane signaling receptor activity
BO993_RS23265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BO993_RS23295	COG0318	PFAM AMP-dependent synthetase and ligase
BO993_RS23300	COG1024	Enoyl-CoA hydratase
BO993_RS23305	COG0784	Response regulator, receiver
BO993_RS23305	COG2205	protein histidine kinase activity
BO993_RS23305	COG2198	Histidine kinase
BO993_RS23380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BO993_RS23390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BO993_RS23395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BO993_RS23405	COG0505	Belongs to the CarA family
BO993_RS23410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BO993_RS23420	COG2258	MOSC domain
BO993_RS23425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BO993_RS23475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BO993_RS23495	COG0477	Major facilitator Superfamily
BO993_RS23505	COG1070	Carbohydrate kinase
BO993_RS23515	COG1501	Belongs to the glycosyl hydrolase 31 family
BO993_RS23530	COG0800	Aldolase
BO993_RS23535	COG4948	Mandelate Racemase Muconate Lactonizing
BO993_RS23545	COG3734	2-keto-3-deoxy-galactonokinase
BO993_RS23550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BO993_RS23560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BO993_RS23580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BO993_RS23585	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BO993_RS23595	COG0351	phosphomethylpyrimidine kinase
BO993_RS23625	COG0583	DNA-binding transcription factor activity
BO993_RS23630	COG1741	Belongs to the pirin family
BO993_RS23655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BO993_RS23660	COG0305	Participates in initiation and elongation during chromosome replication
BO993_RS23685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BO993_RS23690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BO993_RS23695	COG2137	regulation of response to DNA damage stimulus
BO993_RS23700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BO993_RS23715	COG1546	Belongs to the CinA family
BO993_RS23720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BO993_RS23735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BO993_RS23745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BO993_RS23750	COG1534	Rna-binding protein
BO993_RS23765	COG1238	metal cluster binding
BO993_RS23770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BO993_RS23775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BO993_RS23780	COG2840	Smr protein MutS2
BO993_RS23790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BO993_RS23800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BO993_RS23805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BO993_RS23810	COG0148	phosphopyruvate hydratase activity
BO993_RS23820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BO993_RS23825	COG0504	CTP synthase activity
BO993_RS23855	COG0306	phosphate transporter
BO993_RS23870	COG1253	flavin adenine dinucleotide binding
BO993_RS23885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BO993_RS23905	COG0477	Major facilitator Superfamily
BO993_RS23915	COG1132	(ABC) transporter
BO993_RS23920	COG1136	(ABC) transporter
BO993_RS23935	COG0438	transferase activity, transferring glycosyl groups
BO993_RS23945	COG2264	protein methyltransferase activity
BO993_RS23975	COG2244	polysaccharide biosynthetic process
BO993_RS24025	COG1595	DNA-templated transcription, initiation
BO993_RS24040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BO993_RS24060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BO993_RS24130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BO993_RS24135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BO993_RS24185	COG1858	cytochrome C peroxidase
BO993_RS24215	COG0515	serine threonine protein kinase
BO993_RS24220	COG0631	protein serine/threonine phosphatase activity
BO993_RS24345	COG3039	Transposase
BO993_RS24400	COG2154	pterin-4-alpha-carbinolamine dehydratase
BO993_RS24410	COG0428	transporter
BO993_RS24415	COG0428	transporter
BO993_RS24420	COG3064	Membrane
BO993_RS24430	COG1530	ribonuclease E activity
BO993_RS24450	COG1054	Belongs to the UPF0176 family
BO993_RS24470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BO993_RS24525	COG3039	Transposase
BO993_RS24560	COG1648	precorrin-2 dehydrogenase activity
BO993_RS24560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BO993_RS24585	COG0746	molybdenum cofactor guanylyltransferase activity
BO993_RS24655	COG3328	transposase activity
BO993_RS24685	COG4206	TonB-dependent receptor
BO993_RS24735	COG0531	amino acid
BO993_RS24750	COG0006	proline dipeptidase activity
BO993_RS24760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BO993_RS24775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BO993_RS24780	COG3938	Belongs to the proline racemase family
BO993_RS24790	COG0552	protein localization to endoplasmic reticulum
BO993_RS24815	COG0784	Response regulator, receiver
BO993_RS24815	COG4191	Histidine kinase
BO993_RS24940	COG0438	transferase activity, transferring glycosyl groups
BO993_RS24950	COG0438	transferase activity, transferring glycosyl groups
BO993_RS24955	COG0438	transferase activity, transferring glycosyl groups
BO993_RS25010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BO993_RS25025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BO993_RS25065	COG0556	nucleotide-excision repair
BO993_RS25070	COG4969	Belongs to the N-Me-Phe pilin family
BO993_RS25245	COG4962	Type ii secretion system protein e
BO993_RS25260	COG3451	type IV secretory pathway VirB4
BO993_RS25340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone