locus-tag	class	description
GHV42_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GHV42_RS00020	COG0187	DNA topoisomerase II activity
GHV42_RS00030	COG0501	Belongs to the peptidase M48B family
GHV42_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GHV42_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GHV42_RS00085	COG1064	alcohol dehydrogenase
GHV42_RS00090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_RS00095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_RS00105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_RS00115	COG2234	aminopeptidase activity
GHV42_RS00125	COG4942	peptidase
GHV42_RS00130	COG0793	Belongs to the peptidase S41A family
GHV42_RS00175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GHV42_RS00195	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GHV42_RS00210	COG0210	DNA helicase
GHV42_RS00230	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GHV42_RS00235	COG0284	orotidine-5'-phosphate decarboxylase activity
GHV42_RS00265	COG2937	Belongs to the GPAT DAPAT family
GHV42_RS00270	COG3321	synthase
GHV42_RS00270	COG0604	alcohol dehydrogenase
GHV42_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS00310	COG2211	Major facilitator Superfamily
GHV42_RS00330	COG3693	PFAM glycoside hydrolase, family 10
GHV42_RS00365	COG4770	biotin carboxylase activity
GHV42_RS00370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHV42_RS00375	COG1960	acyl-CoA dehydrogenase activity
GHV42_RS00420	COG0523	cobalamin synthesis protein
GHV42_RS00445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GHV42_RS00450	COG1846	Transcriptional regulator
GHV42_RS00455	COG1764	response to oxidative stress
GHV42_RS00485	COG0656	L-ascorbic acid biosynthetic process
GHV42_RS00490	COG2130	NADP-dependent
GHV42_RS00495	COG0667	Aldo Keto reductase
GHV42_RS00505	COG1187	pseudouridine synthase activity
GHV42_RS00515	COG1643	Atp-dependent helicase
GHV42_RS00525	COG4807	Protein conserved in bacteria
GHV42_RS00530	COG2072	flavoprotein involved in K transport
GHV42_RS00550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GHV42_RS00580	COG0129	dihydroxy-acid dehydratase activity
GHV42_RS00590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GHV42_RS00660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GHV42_RS00665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GHV42_RS00675	COG3485	protocatechuate 3,4-dioxygenase
GHV42_RS00680	COG3485	protocatechuate 3,4-dioxygenase
GHV42_RS00695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHV42_RS00700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GHV42_RS00715	COG1414	Transcriptional regulator
GHV42_RS00725	COG0657	acetylesterase activity
GHV42_RS00795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GHV42_RS00835	COG0156	8-amino-7-oxononanoate synthase activity
GHV42_RS00840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GHV42_RS00845	COG1040	competence protein
GHV42_RS00850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GHV42_RS00875	COG2911	Protein conserved in bacteria
GHV42_RS00880	COG0729	surface antigen
GHV42_RS00885	COG4771	TonB-dependent receptor
GHV42_RS00895	COG0457	Tetratricopeptide repeat
GHV42_RS00905	COG0752	glycyl-tRNA synthetase alpha subunit
GHV42_RS00910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GHV42_RS00920	COG3039	Transposase
GHV42_RS00925	COG0519	Catalyzes the synthesis of GMP from XMP
GHV42_RS00925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GHV42_RS00935	COG0805	protein transport
GHV42_RS00940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHV42_RS00945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHV42_RS00955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GHV42_RS00980	COG2974	May be involved in recombination
GHV42_RS01000	COG3661	Belongs to the glycosyl hydrolase 67 family
GHV42_RS01010	COG4948	Mandelate Racemase Muconate Lactonizing
GHV42_RS01020	COG1472	Belongs to the glycosyl hydrolase 3 family
GHV42_RS01025	COG0246	Mannitol dehydrogenase
GHV42_RS01115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GHV42_RS01190	COG3264	Mechanosensitive ion channel
GHV42_RS01190	COG1511	domain protein
GHV42_RS01205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GHV42_RS01210	COG2354	Protein conserved in bacteria
GHV42_RS01215	COG1649	PFAM Uncharacterised BCR, COG1649
GHV42_RS01235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GHV42_RS01260	COG0702	epimerase
GHV42_RS01285	COG3039	Transposase
GHV42_RS01405	COG0084	hydrolase, TatD family'
GHV42_RS01425	COG2814	Major facilitator Superfamily
GHV42_RS01435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GHV42_RS01440	COG1902	pentaerythritol trinitrate reductase activity
GHV42_RS01470	COG0745	RESPONSE REGULATOR receiver
GHV42_RS01490	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GHV42_RS01495	COG0583	DNA-binding transcription factor activity
GHV42_RS01520	COG1733	regulation of RNA biosynthetic process
GHV42_RS01525	COG0702	epimerase
GHV42_RS01565	COG0583	DNA-binding transcription factor activity
GHV42_RS01605	COG1199	ATP-dependent helicase activity
GHV42_RS01610	COG3039	Transposase
GHV42_RS01640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GHV42_RS01670	COG3228	Belongs to the MtfA family
GHV42_RS01680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GHV42_RS01680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GHV42_RS01685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GHV42_RS01700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GHV42_RS01730	COG3237	CsbD-like
GHV42_RS01735	COG0180	Tryptophanyl-tRNA synthetase
GHV42_RS01740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHV42_RS01785	COG0753	catalase activity
GHV42_RS01800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GHV42_RS01835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHV42_RS01845	COG0642	Histidine kinase
GHV42_RS01855	COG1090	epimerase
GHV42_RS01895	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GHV42_RS01915	COG0606	chelatase, subunit chli
GHV42_RS02000	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GHV42_RS02005	COG1166	arginine decarboxylase activity
GHV42_RS02020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GHV42_RS02020	COG2755	lipolytic protein G-D-S-L family
GHV42_RS02025	COG4221	oxidoreductase activity
GHV42_RS02050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GHV42_RS02075	COG0463	Glycosyl transferase, family 2
GHV42_RS02090	COG1475	DNA binding
GHV42_RS02095	COG1192	Involved in chromosome partitioning
GHV42_RS02125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GHV42_RS02135	COG0456	acetyltransferase
GHV42_RS02170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GHV42_RS02175	COG0134	indole-3-glycerol-phosphate synthase activity
GHV42_RS02185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHV42_RS02190	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GHV42_RS02200	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GHV42_RS02210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GHV42_RS02280	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GHV42_RS02295	COG2814	Major facilitator Superfamily
GHV42_RS02310	COG1289	transmembrane transporter activity
GHV42_RS02320	COG0577	efflux transmembrane transporter activity
GHV42_RS02320	COG1136	(ABC) transporter
GHV42_RS02325	COG0151	Belongs to the GarS family
GHV42_RS02330	COG0138	bifunctional purine biosynthesis protein purh
GHV42_RS02360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GHV42_RS02400	COG0439	Biotin carboxylase
GHV42_RS02410	COG0511	ligase activity, forming carbon-carbon bonds
GHV42_RS02415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GHV42_RS02430	COG1324	tolerance protein
GHV42_RS02435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GHV42_RS02455	COG0534	Mate efflux family protein
GHV42_RS02460	COG0616	signal peptide processing
GHV42_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS02485	COG0009	L-threonylcarbamoyladenylate synthase
GHV42_RS02490	COG1754	DNA topoisomerase type I activity
GHV42_RS02490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GHV42_RS02510	COG0758	DNA mediated transformation
GHV42_RS02515	COG1652	LysM domain
GHV42_RS02520	COG0242	peptide deformylase activity
GHV42_RS02525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GHV42_RS02530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GHV42_RS02530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHV42_RS02575	COG1560	Kdo2-lipid A biosynthetic process
GHV42_RS02585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHV42_RS02625	COG0625	glutathione transferase activity
GHV42_RS02670	COG4555	ABC transporter
GHV42_RS02680	COG1476	TRANSCRIPTIONal
GHV42_RS02705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GHV42_RS02710	COG1131	(ABC) transporter
GHV42_RS02715	COG0842	Transport permease protein
GHV42_RS02725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GHV42_RS02745	COG3039	Transposase
GHV42_RS02755	COG3039	Transposase
GHV42_RS02765	COG2951	lytic endotransglycosylase activity
GHV42_RS02800	COG2831	hemolysin activation secretion protein
GHV42_RS02805	COG3210	domain, Protein
GHV42_RS02805	COG3210	domain, Protein
GHV42_RS02815	COG3039	Transposase
GHV42_RS02830	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_RS02855	COG3210	domain, Protein
GHV42_RS02860	COG3039	Transposase
GHV42_RS02930	COG2353	YceI-like domain
GHV42_RS02960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GHV42_RS02995	COG2201	protein-glutamate methylesterase activity
GHV42_RS03055	COG1063	alcohol dehydrogenase
GHV42_RS03085	COG1294	oxidase, subunit
GHV42_RS03090	COG1271	oxidase subunit
GHV42_RS03125	COG2972	Histidine kinase
GHV42_RS03140	COG0531	amino acid
GHV42_RS03160	COG3590	peptidase
GHV42_RS03170	COG0667	Aldo Keto reductase
GHV42_RS03185	COG3384	dioxygenase
GHV42_RS03195	COG1573	uracil-dna glycosylase
GHV42_RS03205	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GHV42_RS03210	COG0025	NhaP-type Na H and K H
GHV42_RS03215	COG1131	(ABC) transporter
GHV42_RS03220	COG0842	Transport permease protein
GHV42_RS03235	COG1404	Belongs to the peptidase S8 family
GHV42_RS03250	COG0745	RESPONSE REGULATOR receiver
GHV42_RS03300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_RS03325	COG2205	protein histidine kinase activity
GHV42_RS03325	COG2202	Pas domain
GHV42_RS03355	COG2813	Specifically methylates the guanine in position
GHV42_RS03360	COG1187	pseudouridine synthase activity
GHV42_RS03365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHV42_RS03400	COG0697	spore germination
GHV42_RS03410	COG2011	ABC-type metal ion transport system permease component
GHV42_RS03445	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHV42_RS03455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GHV42_RS03475	COG0356	it plays a direct role in the translocation of protons across the membrane
GHV42_RS03485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GHV42_RS03495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GHV42_RS03500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GHV42_RS03505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GHV42_RS03530	COG4191	Histidine kinase
GHV42_RS03545	COG1136	(ABC) transporter
GHV42_RS03545	COG0577	efflux transmembrane transporter activity
GHV42_RS03560	COG1136	(ABC) transporter
GHV42_RS03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_RS03570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GHV42_RS03620	COG0339	signal peptide processing
GHV42_RS03650	COG0546	phosphoglycolate phosphatase activity
GHV42_RS03660	COG1956	GAF domain-containing protein
GHV42_RS03665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GHV42_RS03675	COG0720	synthase
GHV42_RS03680	COG0513	Belongs to the DEAD box helicase family
GHV42_RS03695	COG0625	glutathione transferase activity
GHV42_RS03725	COG0626	cystathionine gamma-synthase activity
GHV42_RS03740	COG0110	maltose O-acetyltransferase activity
GHV42_RS03745	COG0438	transferase activity, transferring glycosyl groups
GHV42_RS03745	COG1216	Glycosyl transferase, family 2
GHV42_RS03750	COG3754	Rhamnan synthesis protein F
GHV42_RS03760	COG2226	methyltransferase
GHV42_RS03780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHV42_RS03795	COG0277	FAD linked oxidase domain protein
GHV42_RS03800	COG0546	phosphoglycolate phosphatase activity
GHV42_RS03800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GHV42_RS03815	COG2086	electron transfer activity
GHV42_RS03840	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GHV42_RS03840	COG0662	Cupin 2, conserved barrel domain protein
GHV42_RS03845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHV42_RS03885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GHV42_RS03885	COG3218	ABC-type transport auxiliary lipoprotein component
GHV42_RS03890	COG1127	ABC transporter
GHV42_RS03895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GHV42_RS03910	COG0442	prolyl-tRNA aminoacylation
GHV42_RS03920	COG1183	phosphatidylcholine synthase activity
GHV42_RS03935	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_RS03960	COG0525	valine-tRNA ligase activity
GHV42_RS03975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GHV42_RS03985	COG0795	lipopolysaccharide-transporting ATPase activity
GHV42_RS04000	COG4974	Belongs to the 'phage' integrase family
GHV42_RS04005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GHV42_RS04010	COG0047	phosphoribosylformylglycinamidine synthase activity
GHV42_RS04010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GHV42_RS04015	COG5295	Hep Hag repeat protein
GHV42_RS04020	COG1404	Belongs to the peptidase S8 family
GHV42_RS04025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GHV42_RS04035	COG1459	type II secretion system
GHV42_RS04040	COG2165	general secretion pathway protein
GHV42_RS04045	COG4970	Tfp pilus assembly protein FimT
GHV42_RS04050	COG2165	general secretion pathway protein
GHV42_RS04055	COG4795	General secretion pathway protein
GHV42_RS04060	COG3156	type II secretion system protein K
GHV42_RS04065	COG3166	PFAM Fimbrial assembly family protein
GHV42_RS04080	COG1450	Type ii and iii secretion system protein
GHV42_RS04095	COG2188	Transcriptional regulator
GHV42_RS04145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GHV42_RS04175	COG0242	peptide deformylase activity
GHV42_RS04210	COG1228	amidohydrolase
GHV42_RS04215	COG3964	amidohydrolase
GHV42_RS04235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GHV42_RS04240	COG0726	polysaccharide deacetylase
GHV42_RS04260	COG0436	Aminotransferase
GHV42_RS04290	COG2211	Major facilitator Superfamily
GHV42_RS04300	COG1609	Transcriptional regulator
GHV42_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS04310	COG2851	Citrate transporter
GHV42_RS04325	COG0642	Histidine kinase
GHV42_RS04335	COG2197	response regulator
GHV42_RS04350	COG0583	DNA-binding transcription factor activity
GHV42_RS04365	COG4191	Histidine kinase
GHV42_RS04385	COG0281	malic enzyme
GHV42_RS04385	COG0280	phosphate acetyltransferase
GHV42_RS04410	COG1560	Kdo2-lipid A biosynthetic process
GHV42_RS04415	COG1519	Transferase
GHV42_RS04420	COG1538	Outer membrane efflux protein
GHV42_RS04425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHV42_RS04445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GHV42_RS04450	COG0066	3-isopropylmalate dehydratase activity
GHV42_RS04455	COG2226	methyltransferase
GHV42_RS04485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GHV42_RS04495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GHV42_RS04500	COG3710	Transcriptional regulator
GHV42_RS04525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GHV42_RS04535	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GHV42_RS04570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GHV42_RS04580	COG3781	membrane
GHV42_RS04630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHV42_RS04635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHV42_RS04680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GHV42_RS04690	COG0352	thiamine-phosphate diphosphorylase activity
GHV42_RS04695	COG1773	rubredoxin
GHV42_RS04700	COG2912	Transglutaminase-like superfamily
GHV42_RS04720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GHV42_RS04745	COG0006	proline dipeptidase activity
GHV42_RS04775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GHV42_RS04785	COG0346	lactoylglutathione lyase activity
GHV42_RS04790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GHV42_RS04795	COG1561	YicC-like family, N-terminal region
GHV42_RS04815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHV42_RS04825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GHV42_RS04855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GHV42_RS04890	COG0714	Associated with various cellular activities
GHV42_RS04910	COG2304	oxidoreductase activity
GHV42_RS04945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GHV42_RS05045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GHV42_RS05050	COG4149	molybdate abc transporter
GHV42_RS05055	COG0725	ABC transporter, periplasmic molybdate-binding protein
GHV42_RS05060	COG3453	Protein conserved in bacteria
GHV42_RS05060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHV42_RS05070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GHV42_RS05080	COG0126	phosphoglycerate kinase activity
GHV42_RS05090	COG0469	pyruvate kinase activity
GHV42_RS05095	COG3588	fructose-bisphosphate aldolase
GHV42_RS05100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GHV42_RS05140	COG2205	protein histidine kinase activity
GHV42_RS05140	COG0784	Response regulator, receiver
GHV42_RS05140	COG2198	Histidine kinase
GHV42_RS05160	COG0175	sulfate reduction
GHV42_RS05165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GHV42_RS05170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GHV42_RS05175	COG0175	sulfate reduction
GHV42_RS05180	COG2895	sulfate adenylyltransferase (ATP) activity
GHV42_RS05180	COG0529	Catalyzes the synthesis of activated sulfate
GHV42_RS05190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_RS05195	COG0308	aminopeptidase N
GHV42_RS05215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHV42_RS05240	COG1970	mechanosensitive ion channel activity
GHV42_RS05265	COG3273	potassium ion transport
GHV42_RS05265	COG0471	metal ion transport
GHV42_RS05275	COG2022	thiamine diphosphate biosynthetic process
GHV42_RS05350	COG1074	ATP-dependent DNA helicase activity
GHV42_RS05360	COG3039	Transposase
GHV42_RS05415	COG2003	Belongs to the UPF0758 family
GHV42_RS05450	COG0084	hydrolase, TatD family'
GHV42_RS05530	COG0745	RESPONSE REGULATOR receiver
GHV42_RS05555	COG3039	Transposase
GHV42_RS05565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GHV42_RS05575	COG4969	Belongs to the N-Me-Phe pilin family
GHV42_RS05580	COG2194	sulfuric ester hydrolase activity
GHV42_RS05620	COG0045	succinate-CoA ligase (ADP-forming) activity
GHV42_RS05625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GHV42_RS05635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GHV42_RS05635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHV42_RS05640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_RS05645	COG0564	pseudouridine synthase activity
GHV42_RS05660	COG3011	Protein conserved in bacteria
GHV42_RS05665	COG0840	transmembrane signaling receptor activity
GHV42_RS05680	COG3387	PFAM Glycoside hydrolase 15-related
GHV42_RS05685	COG1877	trehalose-phosphatase activity
GHV42_RS05725	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GHV42_RS05740	COG1595	DNA-templated transcription, initiation
GHV42_RS05750	COG1946	Acyl-CoA thioesterase
GHV42_RS05765	COG0824	Thioesterase
GHV42_RS05770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GHV42_RS05780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GHV42_RS05785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GHV42_RS05790	COG0268	Binds directly to 16S ribosomal RNA
GHV42_RS05795	COG0728	peptidoglycan biosynthetic process
GHV42_RS05800	COG0196	riboflavin kinase activity
GHV42_RS05810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GHV42_RS05815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GHV42_RS05830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GHV42_RS05835	COG1845	cytochrome c oxidase, subunit III
GHV42_RS05840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GHV42_RS05890	COG3039	Transposase
GHV42_RS05935	COG2207	Transcriptional regulator
GHV42_RS05940	COG0326	Molecular chaperone. Has ATPase activity
GHV42_RS05950	COG1366	Belongs to the anti-sigma-factor antagonist family
GHV42_RS05955	COG1366	Belongs to the anti-sigma-factor antagonist family
GHV42_RS05960	COG2172	sigma factor antagonist activity
GHV42_RS06000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHV42_RS06005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GHV42_RS06020	COG2070	2-Nitropropane dioxygenase
GHV42_RS06030	COG0228	four-way junction DNA binding
GHV42_RS06035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GHV42_RS06040	COG0336	Belongs to the RNA methyltransferase TrmD family
GHV42_RS06055	COG0534	Mate efflux family protein
GHV42_RS06065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GHV42_RS06090	COG0542	response to heat
GHV42_RS06140	COG0019	diaminopimelate decarboxylase activity
GHV42_RS06150	COG2814	Major facilitator Superfamily
GHV42_RS06155	COG4264	IucA IucC family
GHV42_RS06165	COG4772	TonB-dependent receptor
GHV42_RS06180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GHV42_RS06180	COG4651	solute:proton antiporter activity
GHV42_RS06210	COG0488	(ABC) transporter
GHV42_RS06235	COG2755	lipolytic protein G-D-S-L family
GHV42_RS06235	COG0657	acetylesterase activity
GHV42_RS06250	COG0477	Major facilitator Superfamily
GHV42_RS06265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GHV42_RS06300	COG2255	four-way junction helicase activity
GHV42_RS06305	COG0824	Thioesterase
GHV42_RS06325	COG0823	Involved in the tonB-independent uptake of proteins
GHV42_RS06330	COG2885	chlorophyll binding
GHV42_RS06340	COG0602	queuosine metabolic process
GHV42_RS06355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GHV42_RS06395	COG4695	Portal protein
GHV42_RS06440	COG3179	chitinase
GHV42_RS06610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GHV42_RS06655	COG1187	pseudouridine synthase activity
GHV42_RS06675	COG0514	ATP-dependent DNA helicase (RecQ)
GHV42_RS06680	COG0783	Belongs to the Dps family
GHV42_RS06685	COG1643	Atp-dependent helicase
GHV42_RS06740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHV42_RS06750	COG1215	transferase activity, transferring glycosyl groups
GHV42_RS06755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GHV42_RS06765	COG1199	ATP-dependent helicase activity
GHV42_RS06785	COG0189	ligase activity
GHV42_RS06800	COG0835	chemotaxis
GHV42_RS06805	COG0840	transmembrane signaling receptor activity
GHV42_RS06810	COG0643	Histidine kinase
GHV42_RS06810	COG0784	Response regulator, receiver
GHV42_RS06810	COG2198	Histidine kinase
GHV42_RS06885	COG2304	oxidoreductase activity
GHV42_RS06890	COG1446	asparaginase
GHV42_RS06935	COG3537	Alpha-1,2-mannosidase
GHV42_RS07000	COG1472	Belongs to the glycosyl hydrolase 3 family
GHV42_RS07015	COG1388	LysM domain
GHV42_RS07015	COG3858	chitin binding
GHV42_RS07030	COG0837	glucose binding
GHV42_RS07035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GHV42_RS07045	COG0494	nUDIX hydrolase
GHV42_RS07055	COG3956	TIGRFAM MazG family protein
GHV42_RS07060	COG1742	UPF0060 membrane protein
GHV42_RS07070	COG0330	HflC and HflK could
GHV42_RS07085	COG0509	glycine decarboxylation via glycine cleavage system
GHV42_RS07120	COG1960	acyl-CoA dehydrogenase activity
GHV42_RS07130	COG1309	transcriptional regulator
GHV42_RS07135	COG4771	TonB-dependent receptor
GHV42_RS07145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GHV42_RS07155	COG0463	Glycosyl transferase, family 2
GHV42_RS07160	COG0517	IMP dehydrogenase activity
GHV42_RS07160	COG0516	GMP reductase activity
GHV42_RS07170	COG1272	protein, Hemolysin III
GHV42_RS07180	COG0739	heme binding
GHV42_RS07185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHV42_RS07190	COG0626	cystathionine gamma-synthase activity
GHV42_RS07200	COG1760	l-serine dehydratase
GHV42_RS07225	COG2353	YceI-like domain
GHV42_RS07230	COG2205	protein histidine kinase activity
GHV42_RS07230	COG0784	Response regulator, receiver
GHV42_RS07230	COG2198	Histidine kinase
GHV42_RS07235	COG5002	protein histidine kinase activity
GHV42_RS07235	COG0784	Response regulator, receiver
GHV42_RS07275	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GHV42_RS07295	COG1960	acyl-CoA dehydrogenase activity
GHV42_RS07335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHV42_RS07345	COG0681	Belongs to the peptidase S26 family
GHV42_RS07365	COG1381	Involved in DNA repair and RecF pathway recombination
GHV42_RS07380	COG2954	triphosphatase activity
GHV42_RS07385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GHV42_RS07390	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GHV42_RS07395	COG3046	protein related to deoxyribodipyrimidine photolyase
GHV42_RS07405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GHV42_RS07410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GHV42_RS07415	COG1278	Cold shock
GHV42_RS07435	COG1201	RNA secondary structure unwinding
GHV42_RS07440	COG1793	dna ligase
GHV42_RS07450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GHV42_RS07450	COG1793	dna ligase
GHV42_RS07465	COG3706	GGDEF domain
GHV42_RS07480	COG0183	Belongs to the thiolase family
GHV42_RS07500	COG1451	nucleotide metabolic process
GHV42_RS07515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GHV42_RS07525	COG3039	Transposase
GHV42_RS07565	COG1047	Peptidyl-prolyl cis-trans
GHV42_RS07575	COG2824	Alkylphosphonate utilization operon protein PhnA
GHV42_RS07590	COG1902	pentaerythritol trinitrate reductase activity
GHV42_RS07595	COG2814	Major facilitator Superfamily
GHV42_RS07630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GHV42_RS07630	COG0392	lysyltransferase activity
GHV42_RS07640	COG0251	oxidation-reduction process
GHV42_RS07645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHV42_RS07660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHV42_RS07685	COG1595	DNA-templated transcription, initiation
GHV42_RS07700	COG2878	Part of a membrane complex involved in electron transport
GHV42_RS07710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHV42_RS07710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHV42_RS07720	COG0346	lactoylglutathione lyase activity
GHV42_RS07725	COG0833	amino acid
GHV42_RS07730	COG2040	homocysteine
GHV42_RS07745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GHV42_RS07765	COG1695	Transcriptional regulator
GHV42_RS07790	COG1981	membrane
GHV42_RS07815	COG0825	malonyl-CoA metabolic process
GHV42_RS07835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHV42_RS07840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GHV42_RS07845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHV42_RS07850	COG3039	Transposase
GHV42_RS07860	COG0750	zinc metalloprotease
GHV42_RS07865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GHV42_RS07870	COG0575	Belongs to the CDS family
GHV42_RS07880	COG0233	cytoplasmic translational termination
GHV42_RS07895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GHV42_RS07955	COG1393	Belongs to the ArsC family
GHV42_RS07965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHV42_RS07970	COG0367	asparagine synthase
GHV42_RS07980	COG4774	siderophore transport
GHV42_RS08000	COG2207	Transcriptional regulator
GHV42_RS08015	COG1566	PFAM secretion protein HlyD family protein
GHV42_RS08020	COG2814	Major facilitator Superfamily
GHV42_RS08125	COG0386	Belongs to the glutathione peroxidase family
GHV42_RS08190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GHV42_RS08195	COG0084	hydrolase, TatD family'
GHV42_RS08210	COG1960	acyl-CoA dehydrogenase activity
GHV42_RS08225	COG0367	asparagine synthase
GHV42_RS08235	COG0305	Participates in initiation and elongation during chromosome replication
GHV42_RS08240	COG0415	Belongs to the DNA photolyase family
GHV42_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS08275	COG3706	GGDEF domain
GHV42_RS08290	COG0489	protein tyrosine kinase activity
GHV42_RS08295	COG0717	Belongs to the dCTP deaminase family
GHV42_RS08320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHV42_RS08335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHV42_RS08350	COG3039	Transposase
GHV42_RS08355	COG0433	COG0433 Predicted ATPase
GHV42_RS08380	COG2890	protein-(glutamine-N5) methyltransferase activity
GHV42_RS08385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GHV42_RS08390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GHV42_RS08395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GHV42_RS08415	COG0101	tRNA pseudouridine synthase activity
GHV42_RS08420	COG0135	phosphoribosylanthranilate isomerase activity
GHV42_RS08430	COG0133	tryptophan synthase activity
GHV42_RS08445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GHV42_RS08450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHV42_RS08490	COG0149	triose-phosphate isomerase activity
GHV42_RS08505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHV42_RS08515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHV42_RS08520	COG0649	NAD binding
GHV42_RS08525	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GHV42_RS08530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GHV42_RS08535	COG1034	ATP synthesis coupled electron transport
GHV42_RS08540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GHV42_RS08570	COG1007	ATP synthesis coupled electron transport
GHV42_RS08580	COG0779	Required for maturation of 30S ribosomal subunits
GHV42_RS08585	COG0195	Participates in both transcription termination and antitermination
GHV42_RS08590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GHV42_RS08605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GHV42_RS08610	COG1185	polyribonucleotide nucleotidyltransferase activity
GHV42_RS08645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GHV42_RS08655	COG2095	MarC family integral membrane protein
GHV42_RS08670	COG1611	Belongs to the LOG family
GHV42_RS08710	COG4969	Belongs to the N-Me-Phe pilin family
GHV42_RS08715	COG0556	nucleotide-excision repair
GHV42_RS08760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GHV42_RS08770	COG2986	histidine ammonia-lyase
GHV42_RS08775	COG1228	amidohydrolase
GHV42_RS08815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GHV42_RS08820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GHV42_RS08825	COG1605	Chorismate mutase
GHV42_RS08825	COG0077	Prephenate dehydratase
GHV42_RS08830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GHV42_RS08850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GHV42_RS08855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GHV42_RS08860	COG0583	DNA-binding transcription factor activity
GHV42_RS08900	COG3039	Transposase
GHV42_RS08940	COG0840	transmembrane signaling receptor activity
GHV42_RS08955	COG0784	Response regulator, receiver
GHV42_RS08955	COG2205	protein histidine kinase activity
GHV42_RS08955	COG5002	protein histidine kinase activity
GHV42_RS08960	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GHV42_RS08970	COG4191	Histidine kinase
GHV42_RS08970	COG0784	Response regulator, receiver
GHV42_RS08975	COG4191	Histidine kinase
GHV42_RS08975	COG0784	Response regulator, receiver
GHV42_RS08990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHV42_RS09010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHV42_RS09025	COG1595	DNA-templated transcription, initiation
GHV42_RS09075	COG2244	polysaccharide biosynthetic process
GHV42_RS09105	COG2264	protein methyltransferase activity
GHV42_RS09115	COG0438	transferase activity, transferring glycosyl groups
GHV42_RS09135	COG1132	(ABC) transporter
GHV42_RS09145	COG0477	Major facilitator Superfamily
GHV42_RS09155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHV42_RS09170	COG1253	flavin adenine dinucleotide binding
GHV42_RS09205	COG0504	CTP synthase activity
GHV42_RS09210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GHV42_RS09220	COG0148	phosphopyruvate hydratase activity
GHV42_RS09225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GHV42_RS09240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GHV42_RS09255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GHV42_RS09260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHV42_RS09265	COG1238	metal cluster binding
GHV42_RS09280	COG1534	Rna-binding protein
GHV42_RS09285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GHV42_RS09295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GHV42_RS09310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GHV42_RS09315	COG1546	Belongs to the CinA family
GHV42_RS09330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GHV42_RS09335	COG2137	regulation of response to DNA damage stimulus
GHV42_RS09340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GHV42_RS09345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GHV42_RS09360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GHV42_RS09380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHV42_RS09405	COG2166	iron-sulfur cluster assembly
GHV42_RS09420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GHV42_RS09425	COG0137	argininosuccinate synthase activity
GHV42_RS09435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHV42_RS09440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GHV42_RS09455	COG0165	Argininosuccinate lyase
GHV42_RS09505	COG1271	oxidase subunit
GHV42_RS09515	COG4988	ABC transporter
GHV42_RS09520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GHV42_RS09580	COG4133	protoheme IX ABC transporter activity
GHV42_RS09585	COG0436	Aminotransferase
GHV42_RS09605	COG1187	pseudouridine synthase activity
GHV42_RS09610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GHV42_RS09615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GHV42_RS09620	COG2350	Protein conserved in bacteria
GHV42_RS09650	COG1175	transmembrane transport
GHV42_RS09655	COG0395	ABC-type sugar transport system, permease component
GHV42_RS09680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHV42_RS09690	COG2957	Belongs to the agmatine deiminase family
GHV42_RS09705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GHV42_RS09710	COG0539	negative regulation of cytoplasmic translation
GHV42_RS09715	COG0776	regulation of translation
GHV42_RS09725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GHV42_RS09730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHV42_RS09740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GHV42_RS09755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GHV42_RS09765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GHV42_RS09765	COG0519	Catalyzes the synthesis of GMP from XMP
GHV42_RS09770	COG3002	Belongs to the UPF0753 family
GHV42_RS09775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHV42_RS09780	COG0583	DNA-binding transcription factor activity
GHV42_RS09805	COG0583	DNA-binding transcription factor activity
GHV42_RS09810	COG0583	DNA-binding transcription factor activity
GHV42_RS09825	COG2201	protein-glutamate methylesterase activity
GHV42_RS09830	COG1914	H( )-stimulated, divalent metal cation uptake system
GHV42_RS09850	COG0668	transmembrane transport
GHV42_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS09880	COG1183	phosphatidylcholine synthase activity
GHV42_RS09890	COG3243	poly(R)-hydroxyalkanoic acid synthase
GHV42_RS09905	COG0723	plastoquinol--plastocyanin reductase activity
GHV42_RS09905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_RS09915	COG2183	response to ionizing radiation
GHV42_RS09925	COG2205	protein histidine kinase activity
GHV42_RS09925	COG0784	Response regulator, receiver
GHV42_RS10050	COG3039	Transposase
GHV42_RS10070	COG3039	Transposase
GHV42_RS10075	COG0800	Aldolase
GHV42_RS10080	COG0129	dihydroxy-acid dehydratase activity
GHV42_RS10085	COG0363	glucosamine-6-phosphate deaminase activity
GHV42_RS10095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GHV42_RS10110	COG0354	folic acid binding
GHV42_RS10125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GHV42_RS10140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GHV42_RS10155	COG4591	ABC-type transport system involved in lipoprotein release permease component
GHV42_RS10180	COG0811	peptide transport
GHV42_RS10195	COG1663	tetraacyldisaccharide 4'-kinase activity
GHV42_RS10205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GHV42_RS10215	COG0322	excinuclease ABC activity
GHV42_RS10265	COG3039	Transposase
GHV42_RS10305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GHV42_RS10325	COG1054	Belongs to the UPF0176 family
GHV42_RS10335	COG1530	ribonuclease E activity
GHV42_RS10345	COG3064	Membrane
GHV42_RS10365	COG2154	pterin-4-alpha-carbinolamine dehydratase
GHV42_RS10435	COG3039	Transposase
GHV42_RS10465	COG3039	Transposase
GHV42_RS10490	COG3039	Transposase
GHV42_RS10630	COG0631	protein serine/threonine phosphatase activity
GHV42_RS10635	COG0515	serine threonine protein kinase
GHV42_RS10665	COG1858	cytochrome C peroxidase
GHV42_RS10715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_RS10720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_RS10775	COG2201	protein-glutamate methylesterase activity
GHV42_RS10815	COG4566	intracellular signal transduction
GHV42_RS10825	COG5001	Diguanylate cyclase
GHV42_RS10875	COG1648	precorrin-2 dehydrogenase activity
GHV42_RS10875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GHV42_RS10900	COG0746	molybdenum cofactor guanylyltransferase activity
GHV42_RS10935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GHV42_RS10950	COG0303	'Molybdopterin
GHV42_RS10955	COG1160	GTP binding
GHV42_RS10960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_RS10980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GHV42_RS10995	COG1024	Enoyl-CoA hydratase
GHV42_RS10995	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHV42_RS11000	COG0183	Belongs to the thiolase family
GHV42_RS11005	COG0038	chloride channel
GHV42_RS11025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GHV42_RS11045	COG1674	ftsk spoiiie
GHV42_RS11050	COG0492	ferredoxin-NADP+ reductase activity
GHV42_RS11075	COG0542	response to heat
GHV42_RS11090	COG0482	sulfurtransferase activity
GHV42_RS11120	COG4585	Histidine kinase
GHV42_RS11130	COG4191	Histidine kinase
GHV42_RS11150	COG0784	Response regulator, receiver
GHV42_RS11150	COG0835	chemotaxis
GHV42_RS11160	COG1558	bacterial-type flagellum-dependent cell motility
GHV42_RS11165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GHV42_RS11175	COG4787	bacterial-type flagellum-dependent cell motility
GHV42_RS11195	COG1705	Flagellar rod assembly protein muramidase FlgJ
GHV42_RS11195	COG3951	Flagellar rod assembly protein muramidase FlgJ
GHV42_RS11210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GHV42_RS11215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GHV42_RS11245	COG2201	protein-glutamate methylesterase activity
GHV42_RS11265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHV42_RS11270	COG4221	oxidoreductase activity
GHV42_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS11315	COG1677	Flagellar hook-basal body complex protein FliE
GHV42_RS11365	COG3190	flagellar
GHV42_RS11380	COG1684	flagellar biosynthetic protein fliR
GHV42_RS11435	COG0643	Histidine kinase
GHV42_RS11435	COG0784	Response regulator, receiver
GHV42_RS11435	COG2198	Histidine kinase
GHV42_RS11580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GHV42_RS11595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GHV42_RS11600	COG1360	Flagellar Motor Protein
GHV42_RS11605	COG1192	Involved in chromosome partitioning
GHV42_RS11610	COG0835	chemotaxis
GHV42_RS11620	COG0745	RESPONSE REGULATOR receiver
GHV42_RS11630	COG0840	transmembrane signaling receptor activity
GHV42_RS11655	COG0840	transmembrane signaling receptor activity
GHV42_RS11660	COG0840	transmembrane signaling receptor activity
GHV42_RS11665	COG0840	transmembrane signaling receptor activity
GHV42_RS11675	COG0840	transmembrane signaling receptor activity
GHV42_RS11680	COG0840	transmembrane signaling receptor activity
GHV42_RS11685	COG0840	transmembrane signaling receptor activity
GHV42_RS11690	COG0840	transmembrane signaling receptor activity
GHV42_RS11700	COG0840	transmembrane signaling receptor activity
GHV42_RS11720	COG0835	chemotaxis
GHV42_RS11730	COG0840	transmembrane signaling receptor activity
GHV42_RS11760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHV42_RS11790	COG0318	PFAM AMP-dependent synthetase and ligase
GHV42_RS11795	COG1024	Enoyl-CoA hydratase
GHV42_RS11800	COG2198	Histidine kinase
GHV42_RS11800	COG0784	Response regulator, receiver
GHV42_RS11800	COG2205	protein histidine kinase activity
GHV42_RS11820	COG3279	Response regulator of the LytR AlgR family
GHV42_RS11835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GHV42_RS11845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHV42_RS11850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GHV42_RS11860	COG0505	Belongs to the CarA family
GHV42_RS11865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GHV42_RS11870	COG2258	MOSC domain
GHV42_RS11875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GHV42_RS11925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GHV42_RS11945	COG0277	FAD linked oxidase domain protein
GHV42_RS11950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GHV42_RS11960	COG0531	amino acid
GHV42_RS11965	COG0531	amino acid
GHV42_RS11970	COG0235	Class ii aldolase
GHV42_RS11975	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GHV42_RS11995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GHV42_RS11995	COG0140	phosphoribosyl-ATP diphosphatase activity
GHV42_RS12005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GHV42_RS12015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GHV42_RS12015	COG0131	Imidazoleglycerol-phosphate dehydratase
GHV42_RS12030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GHV42_RS12040	COG3039	Transposase
GHV42_RS12050	COG0124	histidyl-tRNA synthetase
GHV42_RS12070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GHV42_RS12125	COG1012	belongs to the aldehyde dehydrogenase family
GHV42_RS12145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GHV42_RS12150	COG0697	spore germination
GHV42_RS12155	COG1794	racemase activity, acting on amino acids and derivatives
GHV42_RS12170	COG0671	phosphoesterase, PA-phosphatase related
GHV42_RS12185	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GHV42_RS12195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_RS12205	COG4251	negative regulation of phosphorylation
GHV42_RS12205	COG3706	GGDEF domain
GHV42_RS12205	COG2203	Gaf domain
GHV42_RS12205	COG5001	Diguanylate cyclase
GHV42_RS12225	COG1472	Belongs to the glycosyl hydrolase 3 family
GHV42_RS12250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GHV42_RS12270	COG0617	tRNA 3'-terminal CCA addition
GHV42_RS12280	COG1469	GTP cyclohydrolase I activity
GHV42_RS12285	COG0860	N-Acetylmuramoyl-L-alanine amidase
GHV42_RS12295	COG0477	Major facilitator Superfamily
GHV42_RS12305	COG1070	Carbohydrate kinase
GHV42_RS12330	COG0800	Aldolase
GHV42_RS12335	COG4948	Mandelate Racemase Muconate Lactonizing
GHV42_RS12345	COG3734	2-keto-3-deoxy-galactonokinase
GHV42_RS12350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GHV42_RS12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHV42_RS12375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GHV42_RS12380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GHV42_RS12390	COG0352	thiamine-phosphate diphosphorylase activity
GHV42_RS12390	COG0351	phosphomethylpyrimidine kinase
GHV42_RS12415	COG0583	DNA-binding transcription factor activity
GHV42_RS12420	COG1741	Belongs to the pirin family
GHV42_RS12465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHV42_RS12470	COG0402	S-adenosylhomocysteine deaminase activity
GHV42_RS12485	COG1509	lysine 2,3-aminomutase activity
GHV42_RS12490	COG3300	MHYT domain
GHV42_RS12490	COG5001	Diguanylate cyclase
GHV42_RS12505	COG0483	inositol monophosphate 1-phosphatase activity
GHV42_RS12510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GHV42_RS12535	COG0488	(ABC) transporter
GHV42_RS12540	COG0513	Belongs to the DEAD box helicase family
GHV42_RS12550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GHV42_RS12560	COG0625	glutathione transferase activity
GHV42_RS12565	COG1278	Cold shock
GHV42_RS12570	COG1671	Belongs to the UPF0178 family
GHV42_RS12575	COG4681	YaeQ
GHV42_RS12580	COG2081	HI0933 family
GHV42_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS12620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GHV42_RS12625	COG0860	N-Acetylmuramoyl-L-alanine amidase
GHV42_RS12630	COG0802	atpase or kinase
GHV42_RS12635	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GHV42_RS12635	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GHV42_RS12640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GHV42_RS12660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHV42_RS12725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GHV42_RS12820	COG2801	Transposase and inactivated derivatives
GHV42_RS12835	COG0835	chemotaxis
GHV42_RS12840	COG0840	transmembrane signaling receptor activity
GHV42_RS12865	COG2969	positive regulation of protein catabolic process
GHV42_RS12870	COG0625	glutathione transferase activity
GHV42_RS12875	COG2857	Cytochrome c1
GHV42_RS12880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GHV42_RS12885	COG0723	plastoquinol--plastocyanin reductase activity
GHV42_RS12890	COG0741	lytic transglycosylase activity
GHV42_RS12915	COG1702	phosphate starvation-inducible protein PhoH
GHV42_RS12935	COG4535	Mg2 and Co2 transporter CorC
GHV42_RS12950	COG1012	belongs to the aldehyde dehydrogenase family
GHV42_RS12955	COG1177	transmembrane transport
GHV42_RS12960	COG1176	ABC-type spermidine putrescine transport system, permease component I
GHV42_RS12970	COG3842	ATPase activity
GHV42_RS12990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GHV42_RS13030	COG2201	protein-glutamate methylesterase activity
GHV42_RS13075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GHV42_RS13080	COG0174	glutamine synthetase
GHV42_RS13085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_RS13095	COG0477	Major facilitator Superfamily
GHV42_RS13105	COG0243	molybdopterin cofactor binding
GHV42_RS13125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GHV42_RS13130	COG1121	(ABC) transporter
GHV42_RS13140	COG2733	membrane
GHV42_RS13145	COG5002	protein histidine kinase activity
GHV42_RS13145	COG2205	protein histidine kinase activity
GHV42_RS13145	COG0784	Response regulator, receiver
GHV42_RS13160	COG0477	Major facilitator Superfamily
GHV42_RS13170	COG2902	Dehydrogenase
GHV42_RS13180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_RS13185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_RS13195	COG1609	Transcriptional regulator
GHV42_RS13200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHV42_RS13200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHV42_RS13205	COG1105	Belongs to the carbohydrate kinase PfkB family
GHV42_RS13210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GHV42_RS13210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GHV42_RS13220	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_RS13225	COG3039	Transposase
GHV42_RS13265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GHV42_RS13270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GHV42_RS13275	COG1862	Preprotein translocase
GHV42_RS13280	COG0343	queuine tRNA-ribosyltransferase activity
GHV42_RS13340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GHV42_RS13350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GHV42_RS13355	COG0742	ribosomal rna small subunit methyltransferase
GHV42_RS13360	COG0326	Molecular chaperone. Has ATPase activity
GHV42_RS13390	COG3209	COG3209 Rhs family protein
GHV42_RS13445	COG4206	TonB-dependent receptor
GHV42_RS13495	COG0531	amino acid
GHV42_RS13510	COG0006	proline dipeptidase activity
GHV42_RS13520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHV42_RS13535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_RS13540	COG3938	Belongs to the proline racemase family
GHV42_RS13550	COG0552	protein localization to endoplasmic reticulum
GHV42_RS13560	COG1194	a g-specific adenine glycosylase
GHV42_RS13570	COG0784	Response regulator, receiver
GHV42_RS13570	COG4191	Histidine kinase
GHV42_RS13575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHV42_RS13595	COG3040	lipid binding
GHV42_RS13605	COG1960	acyl-CoA dehydrogenase activity
GHV42_RS13615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GHV42_RS13645	COG0438	transferase activity, transferring glycosyl groups
GHV42_RS13655	COG0438	transferase activity, transferring glycosyl groups
GHV42_RS13660	COG0438	transferase activity, transferring glycosyl groups
GHV42_RS13715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GHV42_RS13730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GHV42_RS13750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GHV42_RS13765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GHV42_RS13780	COG3115	cell septum assembly
GHV42_RS13800	COG0360	Binds together with S18 to 16S ribosomal RNA
GHV42_RS13805	COG0316	Belongs to the HesB IscA family
GHV42_RS13835	COG0288	reversible hydration of carbon dioxide
GHV42_RS13850	COG3844	kynureninase activity
GHV42_RS13860	COG2925	Exonuclease
GHV42_RS13870	COG0667	Aldo Keto reductase
GHV42_RS13895	COG0116	Belongs to the methyltransferase superfamily
GHV42_RS13895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GHV42_RS13940	COG0494	nUDIX hydrolase
GHV42_RS13950	COG1024	Enoyl-CoA hydratase
GHV42_RS13960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GHV42_RS13990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GHV42_RS13995	COG0573	inorganic phosphate transmembrane transporter activity
GHV42_RS14010	COG0704	Plays a role in the regulation of phosphate uptake
GHV42_RS14020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHV42_RS14030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHV42_RS14045	COG0557	exoribonuclease II activity
GHV42_RS14070	COG1960	acyl-CoA dehydrogenase activity
GHV42_RS14075	COG2226	methyltransferase
GHV42_RS14095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHV42_RS14105	COG1609	Transcriptional regulator
GHV42_RS14120	COG2900	Belongs to the SlyX family
GHV42_RS14135	COG0386	Belongs to the glutathione peroxidase family
GHV42_RS14145	COG1725	Transcriptional regulator
GHV42_RS14150	COG1131	(ABC) transporter
GHV42_RS14215	COG2850	peptidyl-arginine hydroxylation
GHV42_RS14250	COG1132	(ABC) transporter
GHV42_RS14260	COG0583	DNA-binding transcription factor activity
GHV42_RS14280	COG3039	Transposase
GHV42_RS14305	COG3039	Transposase
GHV42_RS14335	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GHV42_RS14340	COG0484	heat shock protein binding
GHV42_RS14345	COG0443	Heat shock 70 kDa protein
GHV42_RS14350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GHV42_RS14360	COG0497	DNA recombination
GHV42_RS14370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_RS14375	COG2914	Belongs to the UPF0125 (RnfH) family
GHV42_RS14385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GHV42_RS14470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_RS14475	COG2311	Membrane
GHV42_RS14480	COG1047	Peptidyl-prolyl cis-trans
GHV42_RS14485	COG0791	NLP P60 protein
GHV42_RS14490	COG0791	NLP P60 protein
GHV42_RS14505	COG4106	trans-aconitate 2-methyltransferase activity
GHV42_RS14510	COG1301	dicarboxylic acid transport
GHV42_RS14515	COG1785	Belongs to the alkaline phosphatase family
GHV42_RS14520	COG0037	tRNA processing
GHV42_RS14525	COG1722	exodeoxyribonuclease VII activity
GHV42_RS14530	COG0142	geranyltranstransferase activity
GHV42_RS14535	COG4104	PAAR repeat-containing protein
GHV42_RS14550	COG0312	modulator of DNA gyrase
GHV42_RS14555	COG3028	Belongs to the UPF0307 family
GHV42_RS14560	COG0312	modulator of DNA gyrase
GHV42_RS14570	COG3164	Protein of unknown function
GHV42_RS14585	COG2968	Membrane
GHV42_RS14610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GHV42_RS14630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GHV42_RS14655	COG3118	belongs to the thioredoxin family
GHV42_RS14720	COG1132	(ABC) transporter
GHV42_RS14750	COG0745	RESPONSE REGULATOR receiver
GHV42_RS14755	COG5002	protein histidine kinase activity
GHV42_RS14755	COG5000	phosphorelay sensor kinase activity
GHV42_RS14760	COG0475	glutathione-regulated potassium exporter activity
GHV42_RS14770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GHV42_RS14790	COG1187	pseudouridine synthase activity
GHV42_RS14795	COG5001	Diguanylate cyclase
GHV42_RS14795	COG5002	protein histidine kinase activity
GHV42_RS14845	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GHV42_RS14930	COG0735	belongs to the Fur family
GHV42_RS14935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GHV42_RS14970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GHV42_RS14995	COG0643	Histidine kinase
GHV42_RS14995	COG2198	Histidine kinase
GHV42_RS15000	COG0840	transmembrane signaling receptor activity
GHV42_RS15005	COG0835	chemotaxis
GHV42_RS15010	COG2202	Pas domain
GHV42_RS15010	COG2200	EAL domain
GHV42_RS15010	COG2199	diguanylate cyclase activity
GHV42_RS15015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GHV42_RS15095	COG1515	deoxyribonuclease V activity
GHV42_RS15105	COG1741	Belongs to the pirin family
GHV42_RS15195	COG1741	Belongs to the pirin family
GHV42_RS15200	COG1966	Carbon starvation protein
GHV42_RS15205	COG2879	small protein
GHV42_RS15255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GHV42_RS15260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GHV42_RS15265	COG2080	2 iron, 2 sulfur cluster binding
GHV42_RS15275	COG2203	Gaf domain
GHV42_RS15275	COG5001	Diguanylate cyclase
GHV42_RS15275	COG4251	negative regulation of phosphorylation
GHV42_RS15275	COG3706	GGDEF domain
GHV42_RS15280	COG0629	single-stranded DNA binding
GHV42_RS15285	COG0142	geranyltranstransferase activity
GHV42_RS15310	COG0527	aspartate kinase activity
GHV42_RS15320	COG0384	phenazine biosynthesis protein PhzF
GHV42_RS15330	COG1764	response to oxidative stress
GHV42_RS15345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GHV42_RS15350	COG1678	Uncharacterized ACR, COG1678
GHV42_RS15360	COG0519	Catalyzes the synthesis of GMP from XMP
GHV42_RS15390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GHV42_RS15445	COG1959	2 iron, 2 sulfur cluster binding
GHV42_RS15450	COG0719	Fe-S assembly protein
GHV42_RS15455	COG0396	ATPase activity
GHV42_RS15460	COG0719	Fe-S assembly protein
GHV42_RS15465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GHV42_RS15475	COG2146	nitrite reductase [NAD(P)H] activity
GHV42_RS15495	COG1555	photosystem II stabilization
GHV42_RS15500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHV42_RS15515	COG3178	'Phosphotransferase
GHV42_RS15520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GHV42_RS15535	COG0628	permease
GHV42_RS15545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GHV42_RS15560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GHV42_RS15590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GHV42_RS15600	COG0271	Belongs to the BolA IbaG family
GHV42_RS15610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GHV42_RS15620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GHV42_RS15625	COG1137	ATPase activity
GHV42_RS15640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHV42_RS15650	COG1660	Displays ATPase and GTPase activities
GHV42_RS15660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHV42_RS15665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHV42_RS15670	COG2239	Acts as a magnesium transporter
GHV42_RS15680	COG1294	oxidase, subunit
GHV42_RS15685	COG1271	oxidase subunit
GHV42_RS15695	COG1113	amino acid transport
GHV42_RS15710	COG2197	response regulator
GHV42_RS15715	COG0531	amino acid
GHV42_RS15780	COG0754	glutathionylspermidine amidase activity
GHV42_RS15805	COG1842	Phage shock protein A
GHV42_RS15820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GHV42_RS15960	COG3179	chitinase
GHV42_RS15970	COG3039	Transposase
GHV42_RS16015	COG3039	Transposase
GHV42_RS16075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHV42_RS16195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GHV42_RS16220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GHV42_RS16235	COG2197	response regulator
GHV42_RS16240	COG4585	Histidine kinase
GHV42_RS16255	COG2894	cell division
GHV42_RS16260	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GHV42_RS16270	COG0642	Histidine kinase
GHV42_RS16275	COG0745	RESPONSE REGULATOR receiver
GHV42_RS16280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GHV42_RS16290	COG2194	sulfuric ester hydrolase activity
GHV42_RS16320	COG3551	Protein conserved in bacteria
GHV42_RS16355	COG0753	catalase activity
GHV42_RS16385	COG1917	Cupin 2, conserved barrel domain protein
GHV42_RS16385	COG2207	Transcriptional regulator
GHV42_RS16400	COG1506	peptidase
GHV42_RS16400	COG0823	Involved in the tonB-independent uptake of proteins
GHV42_RS16415	COG1297	OPT oligopeptide transporter protein
GHV42_RS16430	COG0587	DNA-directed DNA polymerase activity
GHV42_RS16500	COG0732	type I restriction modification DNA specificity domain
GHV42_RS16535	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GHV42_RS16545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GHV42_RS16550	COG0732	type I restriction modification DNA specificity domain
GHV42_RS16595	COG0308	aminopeptidase N
GHV42_RS16610	COG0330	HflC and HflK could
GHV42_RS16615	COG0330	HflC and HflK could
GHV42_RS16635	COG0678	peroxiredoxin activity
GHV42_RS16685	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_RS16695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GHV42_RS16710	COG3829	transcription factor binding
GHV42_RS16720	COG3039	Transposase
GHV42_RS16745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GHV42_RS16750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GHV42_RS16760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHV42_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS16790	COG1399	metal-binding, possibly nucleic acid-binding protein
GHV42_RS16810	COG0714	Associated with various cellular activities
GHV42_RS16830	COG0537	adenosine 5'-monophosphoramidase activity
GHV42_RS16840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GHV42_RS16860	COG0314	molybdopterin synthase activity
GHV42_RS16865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GHV42_RS16870	COG0315	cyclic pyranopterin monophosphate synthase activity
GHV42_RS16880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GHV42_RS16885	COG1234	tRNA 3'-trailer cleavage
GHV42_RS16890	COG3642	lipopolysaccharide core region biosynthetic process
GHV42_RS16895	COG0859	PFAM glycosyl transferase family 9
GHV42_RS16910	COG0631	protein serine/threonine phosphatase activity
GHV42_RS16915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHV42_RS16940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHV42_RS16980	COG0544	peptidyl-prolyl cis-trans isomerase activity
GHV42_RS17025	COG0473	3-isopropylmalate dehydrogenase activity
GHV42_RS17040	COG4783	chaperone-mediated protein folding
GHV42_RS17055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GHV42_RS17065	COG0438	transferase activity, transferring glycosyl groups
GHV42_RS17070	COG0671	phosphoesterase, PA-phosphatase related
GHV42_RS17075	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHV42_RS17085	COG3291	Pkd domain containing protein
GHV42_RS17085	COG3291	Pkd domain containing protein
GHV42_RS17095	COG2833	Protein of unknown function (DUF455)
GHV42_RS17115	COG0285	dihydrofolate synthase activity
GHV42_RS17120	COG0406	alpha-ribazole phosphatase activity
GHV42_RS17155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GHV42_RS17160	COG4208	sulfate ABC transporter
GHV42_RS17165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GHV42_RS17170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GHV42_RS17175	COG0156	8-amino-7-oxononanoate synthase activity
GHV42_RS17200	COG0604	alcohol dehydrogenase
GHV42_RS17205	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHV42_RS17205	COG1902	pentaerythritol trinitrate reductase activity
GHV42_RS17235	COG0584	glycerophosphoryl diester phosphodiesterase
GHV42_RS17265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GHV42_RS17270	COG1217	gtp-binding protein TYPA
GHV42_RS17290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GHV42_RS17305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GHV42_RS17310	COG0203	ribosomal protein L17
GHV42_RS17320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GHV42_RS17325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GHV42_RS17335	COG0201	protein transport
GHV42_RS17340	COG0200	Binds to the 23S rRNA
GHV42_RS17345	COG1841	ribosomal large subunit assembly
GHV42_RS17375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GHV42_RS17380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GHV42_RS17385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GHV42_RS17390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GHV42_RS17395	COG0255	Belongs to the universal ribosomal protein uL29 family
GHV42_RS17400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GHV42_RS17410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GHV42_RS17420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GHV42_RS17425	COG0089	rRNA binding
GHV42_RS17430	COG0088	Forms part of the polypeptide exit tunnel
GHV42_RS17440	COG0051	transcription antitermination factor activity, RNA binding
GHV42_RS17460	COG0049	tRNA binding
GHV42_RS17465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GHV42_RS17470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GHV42_RS17475	COG0085	RNA polymerase activity
GHV42_RS17485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GHV42_RS17490	COG0081	regulation of translation
GHV42_RS17495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GHV42_RS17500	COG0250	Participates in transcription elongation, termination and antitermination
GHV42_RS17505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GHV42_RS17535	COG0012	GTP binding
GHV42_RS17540	COG0193	aminoacyl-tRNA hydrolase activity
GHV42_RS17550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GHV42_RS17565	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GHV42_RS17575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GHV42_RS17580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GHV42_RS17590	COG0521	Mo-molybdopterin cofactor biosynthetic process
GHV42_RS17610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHV42_RS17615	COG1295	ribonuclease BN
GHV42_RS17650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GHV42_RS17660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GHV42_RS17715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GHV42_RS17760	COG2890	protein-(glutamine-N5) methyltransferase activity
GHV42_RS17770	COG3634	alkyl hydroperoxide reductase activity
GHV42_RS17775	COG0583	DNA-binding transcription factor activity
GHV42_RS17785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GHV42_RS17790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GHV42_RS17800	COG2197	response regulator
GHV42_RS17825	COG0697	spore germination
GHV42_RS17855	COG3386	PFAM SMP-30 Gluconolaconase
GHV42_RS17865	COG3039	Transposase
GHV42_RS17880	COG1024	Enoyl-CoA hydratase
GHV42_RS17890	COG0318	PFAM AMP-dependent synthetase and ligase
GHV42_RS17895	COG0583	DNA-binding transcription factor activity
GHV42_RS17900	COG3384	dioxygenase
GHV42_RS17930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHV42_RS17935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHV42_RS17945	COG2096	Adenosyltransferase
GHV42_RS17950	COG0123	including yeast histone deacetylase and acetoin utilization protein
GHV42_RS17965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GHV42_RS17975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GHV42_RS17980	COG2967	ApaG domain
GHV42_RS17985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GHV42_RS18005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GHV42_RS18025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GHV42_RS18040	COG0642	Histidine kinase
GHV42_RS18055	COG4181	ATPase activity
GHV42_RS18065	COG2175	clavaminate synthase activity
GHV42_RS18080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GHV42_RS18100	COG0667	Aldo Keto reductase
GHV42_RS18110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GHV42_RS18115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHV42_RS18125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GHV42_RS18140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GHV42_RS18180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GHV42_RS18185	COG2226	methyltransferase
GHV42_RS18235	COG0604	alcohol dehydrogenase
GHV42_RS18235	COG3321	synthase
GHV42_RS18235	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS18245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GHV42_RS18260	COG0494	nUDIX hydrolase
GHV42_RS18275	COG1388	LysM domain
GHV42_RS18275	COG4942	peptidase
GHV42_RS18285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GHV42_RS18305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GHV42_RS18310	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHV42_RS18315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GHV42_RS18330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHV42_RS18335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GHV42_RS18350	COG3116	cell division
GHV42_RS18355	COG0275	rRNA processing
GHV42_RS18395	COG0792	nuclease activity
GHV42_RS18400	COG1988	membrane-bound metal-dependent
GHV42_RS18405	COG0277	FAD linked oxidase domain protein
GHV42_RS18410	COG0745	RESPONSE REGULATOR receiver
GHV42_RS18415	COG2205	protein histidine kinase activity
GHV42_RS18425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GHV42_RS18430	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GHV42_RS18450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GHV42_RS18455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHV42_RS18460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GHV42_RS18480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHV42_RS18480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHV42_RS18495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GHV42_RS18505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GHV42_RS18525	COG0488	(ABC) transporter
GHV42_RS18575	COG2205	protein histidine kinase activity
GHV42_RS18615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GHV42_RS18675	COG0726	polysaccharide deacetylase
GHV42_RS18675	COG1649	PFAM Uncharacterised BCR, COG1649
GHV42_RS18680	COG1215	transferase activity, transferring glycosyl groups
GHV42_RS18690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GHV42_RS18695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GHV42_RS18700	COG1609	Transcriptional regulator
GHV42_RS18710	COG2188	Transcriptional regulator
GHV42_RS18725	COG3250	beta-galactosidase activity
GHV42_RS18760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GHV42_RS18765	COG4191	Histidine kinase
GHV42_RS18770	COG0784	Response regulator, receiver
GHV42_RS18775	COG4251	negative regulation of phosphorylation
GHV42_RS18780	COG2823	Periplasmic or secreted lipoprotein
GHV42_RS18785	COG0673	inositol 2-dehydrogenase activity
GHV42_RS18790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GHV42_RS18825	COG1056	cytidyltransferase-related domain
GHV42_RS18825	COG1051	belongs to the nudix hydrolase family
GHV42_RS18850	COG2921	Belongs to the UPF0250 family
GHV42_RS18860	COG1686	Belongs to the peptidase S11 family
GHV42_RS18865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GHV42_RS18870	COG2951	lytic endotransglycosylase activity
GHV42_RS18930	COG0772	Belongs to the SEDS family
GHV42_RS18945	COG1792	Involved in formation and maintenance of cell shape
GHV42_RS18950	COG1077	Cell shape determining protein MreB Mrl
GHV42_RS18955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHV42_RS18975	COG5001	Diguanylate cyclase
GHV42_RS18975	COG3300	MHYT domain
GHV42_RS19020	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GHV42_RS19040	COG2832	Protein of unknown function (DUF454)
GHV42_RS19050	COG0436	Aminotransferase
GHV42_RS19065	COG1505	serine-type exopeptidase activity
GHV42_RS19090	COG0181	hydroxymethylbilane synthase activity
GHV42_RS19100	COG3275	phosphorelay sensor kinase activity
GHV42_RS19130	COG0659	secondary active sulfate transmembrane transporter activity
GHV42_RS19210	COG0598	Magnesium transport protein CorA
GHV42_RS19220	COG1113	amino acid transport
GHV42_RS19240	COG4305	rare lipoprotein A
GHV42_RS19245	COG0697	spore germination
GHV42_RS19295	COG4221	oxidoreductase activity
GHV42_RS19335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GHV42_RS19360	COG0459	protein refolding
GHV42_RS19390	COG2860	membrane
GHV42_RS19395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHV42_RS19400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GHV42_RS19405	COG3437	response regulator, receiver
GHV42_RS19410	COG2177	Part of the ABC transporter FtsEX involved in
GHV42_RS19415	COG2884	Cell division ATP-binding protein ftsE
GHV42_RS19425	COG3118	belongs to the thioredoxin family
GHV42_RS19430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GHV42_RS19465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GHV42_RS19465	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GHV42_RS19480	COG1473	amidohydrolase
GHV42_RS19485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_RS19490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_RS19520	COG5383	Protein conserved in bacteria
GHV42_RS19570	COG3023	N-Acetylmuramoyl-L-alanine amidase
GHV42_RS19580	COG4948	Mandelate Racemase Muconate Lactonizing
GHV42_RS19595	COG0531	amino acid
GHV42_RS19615	COG4682	membrane
GHV42_RS19620	COG2133	pyrroloquinoline quinone binding
GHV42_RS19640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GHV42_RS19645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GHV42_RS19655	COG1610	YqeY-like protein
GHV42_RS19670	COG1295	ribonuclease BN
GHV42_RS19675	COG0358	DNA primase activity
GHV42_RS19730	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GHV42_RS19745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GHV42_RS19800	COG0739	heme binding
GHV42_RS19815	COG2211	Major facilitator Superfamily
GHV42_RS19820	COG0708	Exodeoxyribonuclease III
GHV42_RS19865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHV42_RS19865	COG2111	Na H antiporter
GHV42_RS19870	COG1006	Multisubunit Na H antiporter MnhC subunit
GHV42_RS19875	COG0651	ATP synthesis coupled electron transport
GHV42_RS19885	COG2212	antiporter activity
GHV42_RS19890	COG1320	monovalent cation:proton antiporter activity
GHV42_RS19900	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GHV42_RS19925	COG3104	oligopeptide transport
GHV42_RS19930	COG3483	tryptophan 2,3-dioxygenase activity
GHV42_RS19940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GHV42_RS19955	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHV42_RS19970	COG3039	Transposase
GHV42_RS19975	COG0513	Belongs to the DEAD box helicase family
GHV42_RS20045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHV42_RS20050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHV42_RS20060	COG0045	succinate-CoA ligase (ADP-forming) activity
GHV42_RS20060	COG1042	CoA-binding domain protein
GHV42_RS20060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GHV42_RS20070	COG2239	Acts as a magnesium transporter
GHV42_RS20100	COG3039	Transposase
GHV42_RS20105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GHV42_RS20125	COG3100	YcgL domain-containing protein
GHV42_RS20130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHV42_RS20140	COG0463	Glycosyl transferase, family 2
GHV42_RS20160	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS20200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GHV42_RS20215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHV42_RS20255	COG0408	coproporphyrinogen oxidase activity
GHV42_RS20330	COG0210	DNA helicase
GHV42_RS20345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GHV42_RS20350	COG0583	DNA-binding transcription factor activity
GHV42_RS20355	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GHV42_RS20365	COG2159	amidohydrolase
GHV42_RS20390	COG0357	Ribosomal RNA small subunit methyltransferase G
GHV42_RS20395	COG3540	Alkaline phosphatase
GHV42_RS20405	COG2091	lysine biosynthetic process via aminoadipic acid
GHV42_RS20420	COG0708	Exodeoxyribonuclease III
GHV42_RS20435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GHV42_RS20440	COG3162	membrane
GHV42_RS20480	COG1414	Transcriptional regulator
GHV42_RS20490	COG2205	protein histidine kinase activity
GHV42_RS20500	COG3459	Glycosyltransferase 36 associated
GHV42_RS20510	COG3265	gluconokinase activity
GHV42_RS20515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_RS20520	COG3039	Transposase
GHV42_RS20535	COG0339	signal peptide processing
GHV42_RS20565	COG0564	pseudouridine synthase activity
GHV42_RS20580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GHV42_RS20590	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHV42_RS20600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHV42_RS20605	COG0318	PFAM AMP-dependent synthetase and ligase
GHV42_RS20610	COG0727	PFAM Uncharacterised protein family (UPF0153)
GHV42_RS20615	COG0596	Alpha beta hydrolase
GHV42_RS20620	COG3177	Filamentation induced by cAMP protein fic
GHV42_RS20625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHV42_RS20640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GHV42_RS20665	COG2205	protein histidine kinase activity
GHV42_RS20670	COG0028	Belongs to the TPP enzyme family
GHV42_RS20685	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GHV42_RS20690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHV42_RS20735	COG0183	Belongs to the thiolase family
GHV42_RS20760	COG3039	Transposase
GHV42_RS20785	COG2032	superoxide dismutase activity
GHV42_RS20790	COG2032	superoxide dismutase activity
GHV42_RS20795	COG2204	response regulator
GHV42_RS20800	COG3852	Histidine kinase
GHV42_RS20805	COG0004	ammonium transporteR
GHV42_RS20810	COG0347	Belongs to the P(II) protein family
GHV42_RS20815	COG0174	glutamine synthetase
GHV42_RS20820	COG1968	undecaprenyl-diphosphatase activity
GHV42_RS20865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GHV42_RS20875	COG2062	phosphohistidine phosphatase, SixA
GHV42_RS20880	COG0489	protein tyrosine kinase activity
GHV42_RS20900	COG1396	sequence-specific DNA binding
GHV42_RS20905	COG3550	peptidyl-serine autophosphorylation
GHV42_RS20910	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GHV42_RS20915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHV42_RS20930	COG1125	glycine betaine transport
GHV42_RS20930	COG0517	IMP dehydrogenase activity
GHV42_RS20945	COG1119	ATPase activity
GHV42_RS20955	COG1473	amidohydrolase
GHV42_RS20960	COG1752	Esterase of the alpha-beta hydrolase superfamily
GHV42_RS20970	COG1522	sequence-specific DNA binding
GHV42_RS20975	COG3186	Phenylalanine-4-hydroxylase
GHV42_RS20995	COG1609	Transcriptional regulator
GHV42_RS21020	COG0366	Alpha amylase catalytic
GHV42_RS21025	COG0366	Alpha amylase catalytic
GHV42_RS21040	COG3039	Transposase
GHV42_RS21075	COG3135	benzoate transporter
GHV42_RS21095	COG0676	glucose-6-phosphate 1-epimerase activity
GHV42_RS21150	COG0302	gtp cyclohydrolase
GHV42_RS21180	COG0477	Major facilitator Superfamily
GHV42_RS21275	COG3237	CsbD-like
GHV42_RS21360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHV42_RS21385	COG3039	Transposase
GHV42_RS21405	COG1755	Isoprenylcysteine carboxyl methyltransferase
GHV42_RS21410	COG1304	FMN binding
GHV42_RS21415	COG3039	Transposase
GHV42_RS21425	COG4772	TonB-dependent receptor
GHV42_RS21435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GHV42_RS21460	COG1272	protein, Hemolysin III
GHV42_RS21465	COG1205	dead DEAH box helicase
GHV42_RS21465	COG1111	helicase
GHV42_RS21525	COG0069	glutamate synthase activity
GHV42_RS21525	COG0067	glutamate synthase
GHV42_RS21525	COG0070	glutamate synthase
GHV42_RS21530	COG0493	'glutamate synthase
GHV42_RS21540	COG0531	amino acid
GHV42_RS21550	COG1322	Protein conserved in bacteria
GHV42_RS21560	COG0386	Belongs to the glutathione peroxidase family
GHV42_RS21565	COG2853	Lipoprotein
GHV42_RS21580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GHV42_RS21585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GHV42_RS21590	COG1127	ABC transporter
GHV42_RS21625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GHV42_RS21630	COG1074	ATP-dependent DNA helicase activity
GHV42_RS21635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GHV42_RS21725	COG2124	cytochrome p450
GHV42_RS21730	COG2124	cytochrome p450
GHV42_RS21735	COG1141	Ferredoxin
GHV42_RS21740	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_RS21745	COG2124	cytochrome p450
GHV42_RS21750	COG0142	geranyltranstransferase activity
GHV42_RS21755	COG1657	PFAM Prenyltransferase squalene oxidase
GHV42_RS21765	COG1304	FMN binding
GHV42_RS21780	COG0564	pseudouridine synthase activity
GHV42_RS21810	COG3706	GGDEF domain
GHV42_RS21820	COG1929	Belongs to the glycerate kinase type-1 family
GHV42_RS21825	COG2271	Major facilitator Superfamily
GHV42_RS21845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GHV42_RS21850	COG0861	Integral membrane protein TerC family
GHV42_RS21860	COG0584	glycerophosphoryl diester phosphodiesterase
GHV42_RS21870	COG0671	phosphoesterase, PA-phosphatase related
GHV42_RS21875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GHV42_RS21880	COG0726	polysaccharide deacetylase