locus-tag	class	description
K2I41_RS00065	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K2I41_RS00070	COG2948	multi-organism process
K2I41_RS00075	COG3504	Conjugal transfer protein
K2I41_RS00210	COG0653	protein targeting
K2I41_RS00220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K2I41_RS00280	COG0489	protein tyrosine kinase activity
K2I41_RS00305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K2I41_RS00320	COG0187	DNA topoisomerase II activity
K2I41_RS00330	COG0501	Belongs to the peptidase M48B family
K2I41_RS00360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K2I41_RS00370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K2I41_RS00385	COG1064	alcohol dehydrogenase
K2I41_RS00390	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_RS00395	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_RS00410	COG3039	Transposase
K2I41_RS00415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_RS00425	COG2234	aminopeptidase activity
K2I41_RS00435	COG4942	peptidase
K2I41_RS00440	COG0793	Belongs to the peptidase S41A family
K2I41_RS00485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K2I41_RS00505	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K2I41_RS00520	COG0210	DNA helicase
K2I41_RS00540	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K2I41_RS00545	COG0284	orotidine-5'-phosphate decarboxylase activity
K2I41_RS00575	COG2937	Belongs to the GPAT DAPAT family
K2I41_RS00580	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS00580	COG3321	synthase
K2I41_RS00580	COG0604	alcohol dehydrogenase
K2I41_RS00625	COG2211	Major facilitator Superfamily
K2I41_RS00645	COG3693	PFAM glycoside hydrolase, family 10
K2I41_RS00680	COG4770	biotin carboxylase activity
K2I41_RS00685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K2I41_RS00690	COG1960	acyl-CoA dehydrogenase activity
K2I41_RS00735	COG0523	cobalamin synthesis protein
K2I41_RS00760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K2I41_RS00765	COG1846	Transcriptional regulator
K2I41_RS00770	COG1764	response to oxidative stress
K2I41_RS00800	COG0656	L-ascorbic acid biosynthetic process
K2I41_RS00805	COG2130	NADP-dependent
K2I41_RS00810	COG0667	Aldo Keto reductase
K2I41_RS00820	COG1187	pseudouridine synthase activity
K2I41_RS00830	COG1643	Atp-dependent helicase
K2I41_RS00840	COG4807	Protein conserved in bacteria
K2I41_RS00845	COG2351	hydroxyisourate hydrolase activity
K2I41_RS00870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K2I41_RS00880	COG0583	DNA-binding transcription factor activity
K2I41_RS00895	COG0129	dihydroxy-acid dehydratase activity
K2I41_RS00905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K2I41_RS00975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K2I41_RS00980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K2I41_RS00990	COG3485	protocatechuate 3,4-dioxygenase
K2I41_RS00995	COG3485	protocatechuate 3,4-dioxygenase
K2I41_RS01010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2I41_RS01015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K2I41_RS01030	COG1414	Transcriptional regulator
K2I41_RS01040	COG0657	acetylesterase activity
K2I41_RS01105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K2I41_RS01145	COG0156	8-amino-7-oxononanoate synthase activity
K2I41_RS01150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K2I41_RS01155	COG1040	competence protein
K2I41_RS01160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K2I41_RS01185	COG2911	Protein conserved in bacteria
K2I41_RS01190	COG0729	surface antigen
K2I41_RS01195	COG4771	TonB-dependent receptor
K2I41_RS01205	COG0457	Tetratricopeptide repeat
K2I41_RS01215	COG0752	glycyl-tRNA synthetase alpha subunit
K2I41_RS01220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K2I41_RS01230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K2I41_RS01230	COG0519	Catalyzes the synthesis of GMP from XMP
K2I41_RS01240	COG0805	protein transport
K2I41_RS01245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2I41_RS01250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2I41_RS01260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K2I41_RS01270	COG3039	Transposase
K2I41_RS01285	COG2974	May be involved in recombination
K2I41_RS01305	COG3661	Belongs to the glycosyl hydrolase 67 family
K2I41_RS01315	COG4948	Mandelate Racemase Muconate Lactonizing
K2I41_RS01325	COG1472	Belongs to the glycosyl hydrolase 3 family
K2I41_RS01330	COG0246	Mannitol dehydrogenase
K2I41_RS01425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K2I41_RS01500	COG1511	domain protein
K2I41_RS01500	COG3264	Mechanosensitive ion channel
K2I41_RS01510	COG3039	Transposase
K2I41_RS01520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K2I41_RS01525	COG2354	Protein conserved in bacteria
K2I41_RS01530	COG1649	PFAM Uncharacterised BCR, COG1649
K2I41_RS01550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K2I41_RS01575	COG0702	epimerase
K2I41_RS01590	COG1858	cytochrome C peroxidase
K2I41_RS01610	COG3209	COG3209 Rhs family protein
K2I41_RS01675	COG3409	Peptidoglycan-binding domain 1 protein
K2I41_RS01675	COG3501	Rhs element vgr protein
K2I41_RS01745	COG0084	hydrolase, TatD family'
K2I41_RS01765	COG2814	Major facilitator Superfamily
K2I41_RS01775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K2I41_RS01780	COG1902	pentaerythritol trinitrate reductase activity
K2I41_RS01810	COG0745	RESPONSE REGULATOR receiver
K2I41_RS01830	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K2I41_RS01835	COG0583	DNA-binding transcription factor activity
K2I41_RS01860	COG1733	regulation of RNA biosynthetic process
K2I41_RS01865	COG0702	epimerase
K2I41_RS01905	COG0583	DNA-binding transcription factor activity
K2I41_RS01945	COG1199	ATP-dependent helicase activity
K2I41_RS01970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K2I41_RS02000	COG3228	Belongs to the MtfA family
K2I41_RS02010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K2I41_RS02010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K2I41_RS02015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K2I41_RS02030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K2I41_RS02065	COG3237	CsbD-like
K2I41_RS02070	COG0180	Tryptophanyl-tRNA synthetase
K2I41_RS02075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K2I41_RS02120	COG0753	catalase activity
K2I41_RS02135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K2I41_RS02170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2I41_RS02190	COG1090	epimerase
K2I41_RS02235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K2I41_RS02255	COG0606	chelatase, subunit chli
K2I41_RS02335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K2I41_RS02340	COG1166	arginine decarboxylase activity
K2I41_RS02355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K2I41_RS02355	COG2755	lipolytic protein G-D-S-L family
K2I41_RS02360	COG4221	oxidoreductase activity
K2I41_RS02385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K2I41_RS02410	COG0463	Glycosyl transferase, family 2
K2I41_RS02425	COG1475	DNA binding
K2I41_RS02430	COG1192	Involved in chromosome partitioning
K2I41_RS02460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K2I41_RS02470	COG0456	acetyltransferase
K2I41_RS02505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K2I41_RS02510	COG0134	indole-3-glycerol-phosphate synthase activity
K2I41_RS02520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2I41_RS02525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K2I41_RS02535	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K2I41_RS02545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K2I41_RS02615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K2I41_RS02630	COG2814	Major facilitator Superfamily
K2I41_RS02645	COG1289	transmembrane transporter activity
K2I41_RS02655	COG1136	(ABC) transporter
K2I41_RS02655	COG0577	efflux transmembrane transporter activity
K2I41_RS02660	COG0151	Belongs to the GarS family
K2I41_RS02665	COG0138	bifunctional purine biosynthesis protein purh
K2I41_RS02690	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K2I41_RS02730	COG0439	Biotin carboxylase
K2I41_RS02740	COG0511	ligase activity, forming carbon-carbon bonds
K2I41_RS02745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K2I41_RS02760	COG1324	tolerance protein
K2I41_RS02765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K2I41_RS02785	COG0534	Mate efflux family protein
K2I41_RS02790	COG0616	signal peptide processing
K2I41_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS02815	COG0009	L-threonylcarbamoyladenylate synthase
K2I41_RS02820	COG1754	DNA topoisomerase type I activity
K2I41_RS02820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K2I41_RS02840	COG0758	DNA mediated transformation
K2I41_RS02845	COG1652	LysM domain
K2I41_RS02850	COG0242	peptide deformylase activity
K2I41_RS02855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K2I41_RS02860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K2I41_RS02860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K2I41_RS02910	COG1560	Kdo2-lipid A biosynthetic process
K2I41_RS02920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K2I41_RS02960	COG0625	glutathione transferase activity
K2I41_RS02995	COG4555	ABC transporter
K2I41_RS03005	COG1476	TRANSCRIPTIONal
K2I41_RS03030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K2I41_RS03035	COG1131	(ABC) transporter
K2I41_RS03040	COG0842	Transport permease protein
K2I41_RS03050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K2I41_RS03070	COG3039	Transposase
K2I41_RS03080	COG2951	lytic endotransglycosylase activity
K2I41_RS03090	COG3039	Transposase
K2I41_RS03120	COG2831	hemolysin activation secretion protein
K2I41_RS03125	COG3210	domain, Protein
K2I41_RS03225	COG2353	YceI-like domain
K2I41_RS03255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K2I41_RS03355	COG1063	alcohol dehydrogenase
K2I41_RS03385	COG1294	oxidase, subunit
K2I41_RS03390	COG1271	oxidase subunit
K2I41_RS03425	COG2972	Histidine kinase
K2I41_RS03440	COG0531	amino acid
K2I41_RS03460	COG3590	peptidase
K2I41_RS03475	COG0667	Aldo Keto reductase
K2I41_RS03490	COG3384	dioxygenase
K2I41_RS03500	COG1573	uracil-dna glycosylase
K2I41_RS03510	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K2I41_RS03515	COG0025	NhaP-type Na H and K H
K2I41_RS03520	COG1131	(ABC) transporter
K2I41_RS03525	COG0842	Transport permease protein
K2I41_RS03540	COG1404	Belongs to the peptidase S8 family
K2I41_RS03555	COG0745	RESPONSE REGULATOR receiver
K2I41_RS03605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_RS03630	COG2202	Pas domain
K2I41_RS03630	COG2205	protein histidine kinase activity
K2I41_RS03660	COG2813	Specifically methylates the guanine in position
K2I41_RS03665	COG1187	pseudouridine synthase activity
K2I41_RS03670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2I41_RS03705	COG0697	spore germination
K2I41_RS03715	COG2011	ABC-type metal ion transport system permease component
K2I41_RS03750	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2I41_RS03760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K2I41_RS03780	COG0356	it plays a direct role in the translocation of protons across the membrane
K2I41_RS03790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K2I41_RS03800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K2I41_RS03805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K2I41_RS03810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K2I41_RS03835	COG4191	Histidine kinase
K2I41_RS03845	COG0577	efflux transmembrane transporter activity
K2I41_RS03845	COG1136	(ABC) transporter
K2I41_RS03850	COG0577	efflux transmembrane transporter activity
K2I41_RS03850	COG1136	(ABC) transporter
K2I41_RS03865	COG1136	(ABC) transporter
K2I41_RS03870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_RS03875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2I41_RS03930	COG0339	signal peptide processing
K2I41_RS03955	COG0546	phosphoglycolate phosphatase activity
K2I41_RS03965	COG1956	GAF domain-containing protein
K2I41_RS03970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K2I41_RS03980	COG0720	synthase
K2I41_RS03985	COG0513	Belongs to the DEAD box helicase family
K2I41_RS03995	COG0625	glutathione transferase activity
K2I41_RS04025	COG0626	cystathionine gamma-synthase activity
K2I41_RS04040	COG0110	maltose O-acetyltransferase activity
K2I41_RS04045	COG0438	transferase activity, transferring glycosyl groups
K2I41_RS04045	COG1216	Glycosyl transferase, family 2
K2I41_RS04050	COG3754	Rhamnan synthesis protein F
K2I41_RS04060	COG2226	methyltransferase
K2I41_RS04080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K2I41_RS04095	COG0277	FAD linked oxidase domain protein
K2I41_RS04100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K2I41_RS04100	COG0546	phosphoglycolate phosphatase activity
K2I41_RS04115	COG2086	electron transfer activity
K2I41_RS04140	COG0662	Cupin 2, conserved barrel domain protein
K2I41_RS04140	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K2I41_RS04145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2I41_RS04185	COG3218	ABC-type transport auxiliary lipoprotein component
K2I41_RS04185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K2I41_RS04190	COG1127	ABC transporter
K2I41_RS04195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K2I41_RS04210	COG0442	prolyl-tRNA aminoacylation
K2I41_RS04220	COG1183	phosphatidylcholine synthase activity
K2I41_RS04250	COG0525	valine-tRNA ligase activity
K2I41_RS04265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K2I41_RS04275	COG0795	lipopolysaccharide-transporting ATPase activity
K2I41_RS04290	COG4974	Belongs to the 'phage' integrase family
K2I41_RS04295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K2I41_RS04300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K2I41_RS04300	COG0047	phosphoribosylformylglycinamidine synthase activity
K2I41_RS04305	COG5295	Hep Hag repeat protein
K2I41_RS04310	COG1404	Belongs to the peptidase S8 family
K2I41_RS04315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K2I41_RS04325	COG1459	type II secretion system
K2I41_RS04330	COG2165	general secretion pathway protein
K2I41_RS04335	COG4970	Tfp pilus assembly protein FimT
K2I41_RS04340	COG2165	general secretion pathway protein
K2I41_RS04345	COG4795	General secretion pathway protein
K2I41_RS04350	COG3156	type II secretion system protein K
K2I41_RS04355	COG3166	PFAM Fimbrial assembly family protein
K2I41_RS04370	COG1450	Type ii and iii secretion system protein
K2I41_RS04385	COG2188	Transcriptional regulator
K2I41_RS04435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K2I41_RS04465	COG0242	peptide deformylase activity
K2I41_RS04505	COG1228	amidohydrolase
K2I41_RS04510	COG3964	amidohydrolase
K2I41_RS04530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K2I41_RS04535	COG0726	polysaccharide deacetylase
K2I41_RS04555	COG0436	Aminotransferase
K2I41_RS04585	COG2211	Major facilitator Superfamily
K2I41_RS04595	COG1609	Transcriptional regulator
K2I41_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS04605	COG2851	Citrate transporter
K2I41_RS04620	COG0642	Histidine kinase
K2I41_RS04630	COG2197	response regulator
K2I41_RS04650	COG0583	DNA-binding transcription factor activity
K2I41_RS04665	COG4191	Histidine kinase
K2I41_RS04685	COG0280	phosphate acetyltransferase
K2I41_RS04685	COG0281	malic enzyme
K2I41_RS04710	COG1560	Kdo2-lipid A biosynthetic process
K2I41_RS04715	COG1519	Transferase
K2I41_RS04720	COG1538	Outer membrane efflux protein
K2I41_RS04725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K2I41_RS04745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K2I41_RS04750	COG0066	3-isopropylmalate dehydratase activity
K2I41_RS04755	COG2226	methyltransferase
K2I41_RS04785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K2I41_RS04795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K2I41_RS04800	COG3710	Transcriptional regulator
K2I41_RS04825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K2I41_RS04835	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K2I41_RS04865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K2I41_RS04875	COG3781	membrane
K2I41_RS04895	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS04910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2I41_RS04915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K2I41_RS04960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K2I41_RS04970	COG0352	thiamine-phosphate diphosphorylase activity
K2I41_RS04975	COG1773	rubredoxin
K2I41_RS04980	COG2912	Transglutaminase-like superfamily
K2I41_RS05000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K2I41_RS05025	COG0006	proline dipeptidase activity
K2I41_RS05060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K2I41_RS05070	COG0346	lactoylglutathione lyase activity
K2I41_RS05075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K2I41_RS05080	COG1561	YicC-like family, N-terminal region
K2I41_RS05100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K2I41_RS05110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K2I41_RS05140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K2I41_RS05175	COG0714	Associated with various cellular activities
K2I41_RS05195	COG2304	oxidoreductase activity
K2I41_RS05230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K2I41_RS05340	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K2I41_RS05345	COG4149	molybdate abc transporter
K2I41_RS05350	COG0725	ABC transporter, periplasmic molybdate-binding protein
K2I41_RS05355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K2I41_RS05355	COG3453	Protein conserved in bacteria
K2I41_RS05365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K2I41_RS05380	COG0126	phosphoglycerate kinase activity
K2I41_RS05390	COG0469	pyruvate kinase activity
K2I41_RS05395	COG3588	fructose-bisphosphate aldolase
K2I41_RS05400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K2I41_RS05440	COG2205	protein histidine kinase activity
K2I41_RS05440	COG0784	Response regulator, receiver
K2I41_RS05440	COG2198	Histidine kinase
K2I41_RS05460	COG0175	sulfate reduction
K2I41_RS05465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K2I41_RS05470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K2I41_RS05475	COG0175	sulfate reduction
K2I41_RS05480	COG0529	Catalyzes the synthesis of activated sulfate
K2I41_RS05480	COG2895	sulfate adenylyltransferase (ATP) activity
K2I41_RS05490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_RS05495	COG0308	aminopeptidase N
K2I41_RS05525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2I41_RS05550	COG1970	mechanosensitive ion channel activity
K2I41_RS05575	COG0471	metal ion transport
K2I41_RS05575	COG3273	potassium ion transport
K2I41_RS05585	COG2022	thiamine diphosphate biosynthetic process
K2I41_RS05605	COG3039	Transposase
K2I41_RS05660	COG0745	RESPONSE REGULATOR receiver
K2I41_RS05695	COG2826	transposase and inactivated derivatives, IS30 family
K2I41_RS05715	COG3209	COG3209 Rhs family protein
K2I41_RS05735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K2I41_RS05745	COG4969	Belongs to the N-Me-Phe pilin family
K2I41_RS05750	COG2194	sulfuric ester hydrolase activity
K2I41_RS05790	COG0045	succinate-CoA ligase (ADP-forming) activity
K2I41_RS05795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K2I41_RS05810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K2I41_RS05810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K2I41_RS05815	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_RS05820	COG0564	pseudouridine synthase activity
K2I41_RS05835	COG3011	Protein conserved in bacteria
K2I41_RS05840	COG0840	transmembrane signaling receptor activity
K2I41_RS05855	COG3387	PFAM Glycoside hydrolase 15-related
K2I41_RS05860	COG1877	trehalose-phosphatase activity
K2I41_RS05900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K2I41_RS05925	COG1946	Acyl-CoA thioesterase
K2I41_RS05940	COG0824	Thioesterase
K2I41_RS05945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K2I41_RS05955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K2I41_RS05960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K2I41_RS05965	COG0268	Binds directly to 16S ribosomal RNA
K2I41_RS05970	COG0728	peptidoglycan biosynthetic process
K2I41_RS05975	COG0196	riboflavin kinase activity
K2I41_RS05985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K2I41_RS05990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K2I41_RS06005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K2I41_RS06010	COG1845	cytochrome c oxidase, subunit III
K2I41_RS06015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K2I41_RS06045	COG3209	COG3209 Rhs family protein
K2I41_RS06100	COG2207	Transcriptional regulator
K2I41_RS06105	COG0326	Molecular chaperone. Has ATPase activity
K2I41_RS06115	COG1366	Belongs to the anti-sigma-factor antagonist family
K2I41_RS06120	COG1366	Belongs to the anti-sigma-factor antagonist family
K2I41_RS06125	COG2172	sigma factor antagonist activity
K2I41_RS06165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K2I41_RS06170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K2I41_RS06185	COG2070	2-Nitropropane dioxygenase
K2I41_RS06195	COG0228	four-way junction DNA binding
K2I41_RS06200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K2I41_RS06205	COG0336	Belongs to the RNA methyltransferase TrmD family
K2I41_RS06220	COG0534	Mate efflux family protein
K2I41_RS06230	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K2I41_RS06255	COG0542	response to heat
K2I41_RS06265	COG3039	Transposase
K2I41_RS06315	COG0019	diaminopimelate decarboxylase activity
K2I41_RS06330	COG4264	IucA IucC family
K2I41_RS06340	COG4772	TonB-dependent receptor
K2I41_RS06355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K2I41_RS06355	COG4651	solute:proton antiporter activity
K2I41_RS06380	COG0488	(ABC) transporter
K2I41_RS06420	COG0477	Major facilitator Superfamily
K2I41_RS06435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K2I41_RS06470	COG2255	four-way junction helicase activity
K2I41_RS06475	COG0824	Thioesterase
K2I41_RS06495	COG0823	Involved in the tonB-independent uptake of proteins
K2I41_RS06500	COG2885	chlorophyll binding
K2I41_RS06510	COG0602	queuosine metabolic process
K2I41_RS06520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K2I41_RS06560	COG1187	pseudouridine synthase activity
K2I41_RS06575	COG0514	ATP-dependent DNA helicase (RecQ)
K2I41_RS06580	COG0783	Belongs to the Dps family
K2I41_RS06585	COG1643	Atp-dependent helicase
K2I41_RS06635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K2I41_RS06645	COG1215	transferase activity, transferring glycosyl groups
K2I41_RS06650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K2I41_RS06660	COG1199	ATP-dependent helicase activity
K2I41_RS06680	COG0189	ligase activity
K2I41_RS06695	COG0835	chemotaxis
K2I41_RS06700	COG0840	transmembrane signaling receptor activity
K2I41_RS06800	COG2304	oxidoreductase activity
K2I41_RS06805	COG1446	asparaginase
K2I41_RS06850	COG3537	Alpha-1,2-mannosidase
K2I41_RS06890	COG1472	Belongs to the glycosyl hydrolase 3 family
K2I41_RS06900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K2I41_RS06905	COG1388	LysM domain
K2I41_RS06905	COG3858	chitin binding
K2I41_RS06920	COG0837	glucose binding
K2I41_RS06925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K2I41_RS06935	COG0494	nUDIX hydrolase
K2I41_RS06945	COG3956	TIGRFAM MazG family protein
K2I41_RS06950	COG1742	UPF0060 membrane protein
K2I41_RS06960	COG0330	HflC and HflK could
K2I41_RS06975	COG0509	glycine decarboxylation via glycine cleavage system
K2I41_RS07005	COG1960	acyl-CoA dehydrogenase activity
K2I41_RS07015	COG1309	transcriptional regulator
K2I41_RS07020	COG4771	TonB-dependent receptor
K2I41_RS07030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K2I41_RS07040	COG0463	Glycosyl transferase, family 2
K2I41_RS07045	COG0516	GMP reductase activity
K2I41_RS07045	COG0517	IMP dehydrogenase activity
K2I41_RS07060	COG1272	protein, Hemolysin III
K2I41_RS07070	COG0739	heme binding
K2I41_RS07075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2I41_RS07080	COG0626	cystathionine gamma-synthase activity
K2I41_RS07090	COG1760	l-serine dehydratase
K2I41_RS07115	COG2353	YceI-like domain
K2I41_RS07120	COG0784	Response regulator, receiver
K2I41_RS07120	COG2198	Histidine kinase
K2I41_RS07120	COG2205	protein histidine kinase activity
K2I41_RS07125	COG5002	protein histidine kinase activity
K2I41_RS07125	COG0784	Response regulator, receiver
K2I41_RS07190	COG1960	acyl-CoA dehydrogenase activity
K2I41_RS07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2I41_RS07235	COG0481	GTPase activity
K2I41_RS07240	COG0681	Belongs to the peptidase S26 family
K2I41_RS07260	COG1381	Involved in DNA repair and RecF pathway recombination
K2I41_RS07275	COG2954	triphosphatase activity
K2I41_RS07280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K2I41_RS07285	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
K2I41_RS07290	COG3046	protein related to deoxyribodipyrimidine photolyase
K2I41_RS07300	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K2I41_RS07305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K2I41_RS07310	COG1278	Cold shock
K2I41_RS07340	COG1201	RNA secondary structure unwinding
K2I41_RS07345	COG1793	dna ligase
K2I41_RS07355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K2I41_RS07355	COG1793	dna ligase
K2I41_RS07385	COG0183	Belongs to the thiolase family
K2I41_RS07410	COG1451	nucleotide metabolic process
K2I41_RS07425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K2I41_RS07475	COG1047	Peptidyl-prolyl cis-trans
K2I41_RS07485	COG2824	Alkylphosphonate utilization operon protein PhnA
K2I41_RS07490	COG3039	Transposase
K2I41_RS07500	COG1902	pentaerythritol trinitrate reductase activity
K2I41_RS07505	COG2814	Major facilitator Superfamily
K2I41_RS07540	COG0392	lysyltransferase activity
K2I41_RS07540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K2I41_RS07550	COG0251	oxidation-reduction process
K2I41_RS07555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2I41_RS07570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2I41_RS07595	COG1595	DNA-templated transcription, initiation
K2I41_RS07610	COG2878	Part of a membrane complex involved in electron transport
K2I41_RS07620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2I41_RS07620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2I41_RS07630	COG0346	lactoylglutathione lyase activity
K2I41_RS07635	COG0833	amino acid
K2I41_RS07640	COG2040	homocysteine
K2I41_RS07655	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K2I41_RS07675	COG1695	Transcriptional regulator
K2I41_RS07700	COG1981	membrane
K2I41_RS07725	COG0825	malonyl-CoA metabolic process
K2I41_RS07745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K2I41_RS07750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K2I41_RS07755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K2I41_RS07760	COG3039	Transposase
K2I41_RS07770	COG0750	zinc metalloprotease
K2I41_RS07775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K2I41_RS07780	COG0575	Belongs to the CDS family
K2I41_RS07790	COG0233	cytoplasmic translational termination
K2I41_RS07805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K2I41_RS07865	COG1393	Belongs to the ArsC family
K2I41_RS07875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2I41_RS07880	COG0367	asparagine synthase
K2I41_RS07890	COG4774	siderophore transport
K2I41_RS07910	COG2207	Transcriptional regulator
K2I41_RS07925	COG1566	PFAM secretion protein HlyD family protein
K2I41_RS07930	COG2814	Major facilitator Superfamily
K2I41_RS08000	COG1595	DNA-templated transcription, initiation
K2I41_RS08040	COG0386	Belongs to the glutathione peroxidase family
K2I41_RS08110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K2I41_RS08115	COG0084	hydrolase, TatD family'
K2I41_RS08130	COG1960	acyl-CoA dehydrogenase activity
K2I41_RS08145	COG0367	asparagine synthase
K2I41_RS08155	COG0305	Participates in initiation and elongation during chromosome replication
K2I41_RS08160	COG0415	Belongs to the DNA photolyase family
K2I41_RS08195	COG3706	GGDEF domain
K2I41_RS08210	COG0489	protein tyrosine kinase activity
K2I41_RS08215	COG0717	Belongs to the dCTP deaminase family
K2I41_RS08240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K2I41_RS08255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K2I41_RS08275	COG0433	COG0433 Predicted ATPase
K2I41_RS08300	COG2890	protein-(glutamine-N5) methyltransferase activity
K2I41_RS08305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K2I41_RS08310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2I41_RS08315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K2I41_RS08335	COG0101	tRNA pseudouridine synthase activity
K2I41_RS08340	COG0135	phosphoribosylanthranilate isomerase activity
K2I41_RS08350	COG0133	tryptophan synthase activity
K2I41_RS08365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K2I41_RS08370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2I41_RS08410	COG0149	triose-phosphate isomerase activity
K2I41_RS08425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2I41_RS08435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2I41_RS08440	COG0649	NAD binding
K2I41_RS08445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K2I41_RS08450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K2I41_RS08455	COG1034	ATP synthesis coupled electron transport
K2I41_RS08460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K2I41_RS08490	COG1007	ATP synthesis coupled electron transport
K2I41_RS08500	COG0779	Required for maturation of 30S ribosomal subunits
K2I41_RS08505	COG0195	Participates in both transcription termination and antitermination
K2I41_RS08510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K2I41_RS08525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K2I41_RS08530	COG1185	polyribonucleotide nucleotidyltransferase activity
K2I41_RS08565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K2I41_RS08575	COG2095	MarC family integral membrane protein
K2I41_RS08590	COG1611	Belongs to the LOG family
K2I41_RS08630	COG4969	Belongs to the N-Me-Phe pilin family
K2I41_RS08635	COG0556	nucleotide-excision repair
K2I41_RS08670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K2I41_RS08680	COG2986	histidine ammonia-lyase
K2I41_RS08685	COG1228	amidohydrolase
K2I41_RS08725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K2I41_RS08730	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K2I41_RS08735	COG0077	Prephenate dehydratase
K2I41_RS08735	COG1605	Chorismate mutase
K2I41_RS08740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K2I41_RS08760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K2I41_RS08765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K2I41_RS08770	COG0583	DNA-binding transcription factor activity
K2I41_RS08815	COG1002	Type II restriction enzyme, methylase subunits
K2I41_RS08820	COG3039	Transposase
K2I41_RS08825	COG1061	Type III restriction enzyme res subunit
K2I41_RS08830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K2I41_RS08845	COG3039	Transposase
K2I41_RS08875	COG3039	Transposase
K2I41_RS08915	COG2003	Belongs to the UPF0758 family
K2I41_RS09025	COG3039	Transposase
K2I41_RS09065	COG0840	transmembrane signaling receptor activity
K2I41_RS09080	COG0784	Response regulator, receiver
K2I41_RS09080	COG2205	protein histidine kinase activity
K2I41_RS09080	COG5002	protein histidine kinase activity
K2I41_RS09085	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K2I41_RS09105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K2I41_RS09125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K2I41_RS09140	COG1595	DNA-templated transcription, initiation
K2I41_RS09190	COG2244	polysaccharide biosynthetic process
K2I41_RS09220	COG2264	protein methyltransferase activity
K2I41_RS09230	COG0438	transferase activity, transferring glycosyl groups
K2I41_RS09245	COG1136	(ABC) transporter
K2I41_RS09250	COG1132	(ABC) transporter
K2I41_RS09260	COG2271	Major facilitator Superfamily
K2I41_RS09270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2I41_RS09285	COG1253	flavin adenine dinucleotide binding
K2I41_RS09320	COG0504	CTP synthase activity
K2I41_RS09325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K2I41_RS09335	COG0148	phosphopyruvate hydratase activity
K2I41_RS09340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K2I41_RS09355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K2I41_RS09370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K2I41_RS09375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K2I41_RS09380	COG1238	metal cluster binding
K2I41_RS09395	COG1534	Rna-binding protein
K2I41_RS09400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K2I41_RS09410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K2I41_RS09425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K2I41_RS09430	COG1546	Belongs to the CinA family
K2I41_RS09445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K2I41_RS09450	COG2137	regulation of response to DNA damage stimulus
K2I41_RS09455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K2I41_RS09460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K2I41_RS09470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K2I41_RS09495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K2I41_RS09535	COG2166	iron-sulfur cluster assembly
K2I41_RS09550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K2I41_RS09555	COG0137	argininosuccinate synthase activity
K2I41_RS09565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2I41_RS09570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K2I41_RS09585	COG0165	Argininosuccinate lyase
K2I41_RS09640	COG4988	ABC transporter
K2I41_RS09645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K2I41_RS09705	COG4133	protoheme IX ABC transporter activity
K2I41_RS09710	COG0436	Aminotransferase
K2I41_RS09730	COG1187	pseudouridine synthase activity
K2I41_RS09735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K2I41_RS09740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K2I41_RS09745	COG2350	Protein conserved in bacteria
K2I41_RS09775	COG1175	transmembrane transport
K2I41_RS09780	COG0395	ABC-type sugar transport system, permease component
K2I41_RS09805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K2I41_RS09815	COG2957	Belongs to the agmatine deiminase family
K2I41_RS09830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K2I41_RS09835	COG0539	negative regulation of cytoplasmic translation
K2I41_RS09840	COG0776	regulation of translation
K2I41_RS09850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K2I41_RS09855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K2I41_RS09865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K2I41_RS09885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K2I41_RS09895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K2I41_RS09895	COG0519	Catalyzes the synthesis of GMP from XMP
K2I41_RS09900	COG0582	viral genome integration into host DNA
K2I41_RS09970	COG1002	Type II restriction enzyme, methylase subunits
K2I41_RS09975	COG1061	Type III restriction enzyme res subunit
K2I41_RS09980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K2I41_RS09995	COG3002	Belongs to the UPF0753 family
K2I41_RS10000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K2I41_RS10005	COG0583	DNA-binding transcription factor activity
K2I41_RS10050	COG1914	H( )-stimulated, divalent metal cation uptake system
K2I41_RS10070	COG0668	transmembrane transport
K2I41_RS10095	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS10100	COG1183	phosphatidylcholine synthase activity
K2I41_RS10110	COG3243	poly(R)-hydroxyalkanoic acid synthase
K2I41_RS10125	COG0723	plastoquinol--plastocyanin reductase activity
K2I41_RS10125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_RS10135	COG2183	response to ionizing radiation
K2I41_RS10145	COG0784	Response regulator, receiver
K2I41_RS10145	COG2205	protein histidine kinase activity
K2I41_RS10265	COG3039	Transposase
K2I41_RS10270	COG3039	Transposase
K2I41_RS10290	COG3039	Transposase
K2I41_RS10295	COG0800	Aldolase
K2I41_RS10300	COG0129	dihydroxy-acid dehydratase activity
K2I41_RS10305	COG0363	glucosamine-6-phosphate deaminase activity
K2I41_RS10315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K2I41_RS10330	COG0354	folic acid binding
K2I41_RS10345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K2I41_RS10360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K2I41_RS10375	COG4591	ABC-type transport system involved in lipoprotein release permease component
K2I41_RS10395	COG0811	peptide transport
K2I41_RS10410	COG1663	tetraacyldisaccharide 4'-kinase activity
K2I41_RS10420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K2I41_RS10430	COG0322	excinuclease ABC activity
K2I41_RS10455	COG0582	viral genome integration into host DNA
K2I41_RS10480	COG3039	Transposase
K2I41_RS10520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K2I41_RS10540	COG1054	Belongs to the UPF0176 family
K2I41_RS10550	COG1530	ribonuclease E activity
K2I41_RS10575	COG2154	pterin-4-alpha-carbinolamine dehydratase
K2I41_RS10735	COG0631	protein serine/threonine phosphatase activity
K2I41_RS10740	COG0515	serine threonine protein kinase
K2I41_RS10770	COG1858	cytochrome C peroxidase
K2I41_RS10830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_RS10835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_RS10890	COG2201	protein-glutamate methylesterase activity
K2I41_RS10930	COG4566	intracellular signal transduction
K2I41_RS10940	COG5001	Diguanylate cyclase
K2I41_RS11000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K2I41_RS11000	COG1648	precorrin-2 dehydrogenase activity
K2I41_RS11025	COG0746	molybdenum cofactor guanylyltransferase activity
K2I41_RS11055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K2I41_RS11070	COG0303	'Molybdopterin
K2I41_RS11085	COG1160	GTP binding
K2I41_RS11090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_RS11110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K2I41_RS11125	COG1024	Enoyl-CoA hydratase
K2I41_RS11125	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2I41_RS11130	COG0183	Belongs to the thiolase family
K2I41_RS11135	COG0038	chloride channel
K2I41_RS11155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K2I41_RS11175	COG1674	ftsk spoiiie
K2I41_RS11180	COG0492	ferredoxin-NADP+ reductase activity
K2I41_RS11245	COG0653	protein targeting
K2I41_RS11255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K2I41_RS11285	COG0542	response to heat
K2I41_RS11300	COG0482	sulfurtransferase activity
K2I41_RS11330	COG4585	Histidine kinase
K2I41_RS11340	COG4191	Histidine kinase
K2I41_RS11360	COG0784	Response regulator, receiver
K2I41_RS11360	COG0835	chemotaxis
K2I41_RS11370	COG1558	bacterial-type flagellum-dependent cell motility
K2I41_RS11375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K2I41_RS11385	COG4787	bacterial-type flagellum-dependent cell motility
K2I41_RS11405	COG3951	Flagellar rod assembly protein muramidase FlgJ
K2I41_RS11405	COG1705	Flagellar rod assembly protein muramidase FlgJ
K2I41_RS11420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K2I41_RS11425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K2I41_RS11450	COG2197	response regulator
K2I41_RS11460	COG2201	protein-glutamate methylesterase activity
K2I41_RS11480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2I41_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS11525	COG3039	Transposase
K2I41_RS11530	COG1677	Flagellar hook-basal body complex protein FliE
K2I41_RS11580	COG3190	flagellar
K2I41_RS11595	COG1684	flagellar biosynthetic protein fliR
K2I41_RS11650	COG0784	Response regulator, receiver
K2I41_RS11650	COG2198	Histidine kinase
K2I41_RS11650	COG0643	Histidine kinase
K2I41_RS11775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K2I41_RS11780	COG4774	siderophore transport
K2I41_RS11790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K2I41_RS11795	COG1360	Flagellar Motor Protein
K2I41_RS11800	COG1192	Involved in chromosome partitioning
K2I41_RS11805	COG0835	chemotaxis
K2I41_RS11815	COG0745	RESPONSE REGULATOR receiver
K2I41_RS11825	COG0840	transmembrane signaling receptor activity
K2I41_RS11850	COG0840	transmembrane signaling receptor activity
K2I41_RS11855	COG0840	transmembrane signaling receptor activity
K2I41_RS11860	COG0840	transmembrane signaling receptor activity
K2I41_RS11870	COG0840	transmembrane signaling receptor activity
K2I41_RS11875	COG0840	transmembrane signaling receptor activity
K2I41_RS11880	COG0840	transmembrane signaling receptor activity
K2I41_RS11885	COG0840	transmembrane signaling receptor activity
K2I41_RS11890	COG0840	transmembrane signaling receptor activity
K2I41_RS11905	COG0835	chemotaxis
K2I41_RS11915	COG0840	transmembrane signaling receptor activity
K2I41_RS11945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2I41_RS11975	COG0318	PFAM AMP-dependent synthetase and ligase
K2I41_RS11980	COG1024	Enoyl-CoA hydratase
K2I41_RS11985	COG2205	protein histidine kinase activity
K2I41_RS11985	COG2198	Histidine kinase
K2I41_RS11985	COG0784	Response regulator, receiver
K2I41_RS12020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K2I41_RS12030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K2I41_RS12035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K2I41_RS12045	COG0505	Belongs to the CarA family
K2I41_RS12050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K2I41_RS12055	COG2258	MOSC domain
K2I41_RS12060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K2I41_RS12105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K2I41_RS12125	COG0277	FAD linked oxidase domain protein
K2I41_RS12130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K2I41_RS12140	COG0531	amino acid
K2I41_RS12145	COG0531	amino acid
K2I41_RS12150	COG0235	Class ii aldolase
K2I41_RS12155	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K2I41_RS12175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K2I41_RS12175	COG0140	phosphoribosyl-ATP diphosphatase activity
K2I41_RS12185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K2I41_RS12195	COG0131	Imidazoleglycerol-phosphate dehydratase
K2I41_RS12195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K2I41_RS12210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K2I41_RS12220	COG3039	Transposase
K2I41_RS12230	COG0124	histidyl-tRNA synthetase
K2I41_RS12245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K2I41_RS12300	COG1012	belongs to the aldehyde dehydrogenase family
K2I41_RS12325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K2I41_RS12330	COG0697	spore germination
K2I41_RS12350	COG0671	phosphoesterase, PA-phosphatase related
K2I41_RS12365	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K2I41_RS12370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_RS12380	COG5001	Diguanylate cyclase
K2I41_RS12380	COG4251	negative regulation of phosphorylation
K2I41_RS12380	COG3706	GGDEF domain
K2I41_RS12380	COG2203	Gaf domain
K2I41_RS12395	COG1472	Belongs to the glycosyl hydrolase 3 family
K2I41_RS12420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K2I41_RS12440	COG0617	tRNA 3'-terminal CCA addition
K2I41_RS12450	COG1469	GTP cyclohydrolase I activity
K2I41_RS12455	COG0860	N-Acetylmuramoyl-L-alanine amidase
K2I41_RS12465	COG0477	Major facilitator Superfamily
K2I41_RS12475	COG1070	Carbohydrate kinase
K2I41_RS12500	COG0800	Aldolase
K2I41_RS12505	COG4948	Mandelate Racemase Muconate Lactonizing
K2I41_RS12515	COG3734	2-keto-3-deoxy-galactonokinase
K2I41_RS12520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K2I41_RS12530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2I41_RS12545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K2I41_RS12550	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K2I41_RS12560	COG0351	phosphomethylpyrimidine kinase
K2I41_RS12560	COG0352	thiamine-phosphate diphosphorylase activity
K2I41_RS12585	COG0583	DNA-binding transcription factor activity
K2I41_RS12590	COG1741	Belongs to the pirin family
K2I41_RS12635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2I41_RS12640	COG0402	S-adenosylhomocysteine deaminase activity
K2I41_RS12655	COG1509	lysine 2,3-aminomutase activity
K2I41_RS12660	COG3300	MHYT domain
K2I41_RS12660	COG5001	Diguanylate cyclase
K2I41_RS12675	COG0483	inositol monophosphate 1-phosphatase activity
K2I41_RS12680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K2I41_RS12705	COG0488	(ABC) transporter
K2I41_RS12710	COG0513	Belongs to the DEAD box helicase family
K2I41_RS12720	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K2I41_RS12730	COG0625	glutathione transferase activity
K2I41_RS12740	COG1671	Belongs to the UPF0178 family
K2I41_RS12745	COG4681	YaeQ
K2I41_RS12750	COG2081	HI0933 family
K2I41_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS12790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K2I41_RS12795	COG0860	N-Acetylmuramoyl-L-alanine amidase
K2I41_RS12800	COG0802	atpase or kinase
K2I41_RS12805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K2I41_RS12805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K2I41_RS12810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K2I41_RS12830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_RS12900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K2I41_RS13005	COG2801	Transposase and inactivated derivatives
K2I41_RS13020	COG0835	chemotaxis
K2I41_RS13025	COG0840	transmembrane signaling receptor activity
K2I41_RS13050	COG2969	positive regulation of protein catabolic process
K2I41_RS13055	COG0625	glutathione transferase activity
K2I41_RS13060	COG2857	Cytochrome c1
K2I41_RS13065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K2I41_RS13070	COG0723	plastoquinol--plastocyanin reductase activity
K2I41_RS13075	COG0741	lytic transglycosylase activity
K2I41_RS13100	COG1702	phosphate starvation-inducible protein PhoH
K2I41_RS13120	COG4535	Mg2 and Co2 transporter CorC
K2I41_RS13135	COG1012	belongs to the aldehyde dehydrogenase family
K2I41_RS13140	COG1177	transmembrane transport
K2I41_RS13145	COG1176	ABC-type spermidine putrescine transport system, permease component I
K2I41_RS13155	COG3842	ATPase activity
K2I41_RS13175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K2I41_RS13205	COG2201	protein-glutamate methylesterase activity
K2I41_RS13250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K2I41_RS13255	COG0174	glutamine synthetase
K2I41_RS13260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_RS13270	COG0477	Major facilitator Superfamily
K2I41_RS13280	COG0243	molybdopterin cofactor binding
K2I41_RS13300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K2I41_RS13310	COG3039	Transposase
K2I41_RS13315	COG3039	Transposase
K2I41_RS13320	COG1121	(ABC) transporter
K2I41_RS13330	COG2733	membrane
K2I41_RS13335	COG2205	protein histidine kinase activity
K2I41_RS13335	COG5002	protein histidine kinase activity
K2I41_RS13335	COG0784	Response regulator, receiver
K2I41_RS13350	COG0477	Major facilitator Superfamily
K2I41_RS13360	COG2902	Dehydrogenase
K2I41_RS13370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_RS13375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_RS13385	COG1609	Transcriptional regulator
K2I41_RS13390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K2I41_RS13390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2I41_RS13395	COG1105	Belongs to the carbohydrate kinase PfkB family
K2I41_RS13400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K2I41_RS13400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K2I41_RS13410	COG3039	Transposase
K2I41_RS13455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K2I41_RS13460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K2I41_RS13465	COG1862	Preprotein translocase
K2I41_RS13470	COG0343	queuine tRNA-ribosyltransferase activity
K2I41_RS13530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K2I41_RS13540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K2I41_RS13545	COG0742	ribosomal rna small subunit methyltransferase
K2I41_RS13550	COG0326	Molecular chaperone. Has ATPase activity
K2I41_RS13590	COG4206	TonB-dependent receptor
K2I41_RS13620	COG0531	amino acid
K2I41_RS13635	COG0006	proline dipeptidase activity
K2I41_RS13645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2I41_RS13660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_RS13665	COG3938	Belongs to the proline racemase family
K2I41_RS13675	COG0552	protein localization to endoplasmic reticulum
K2I41_RS13685	COG1194	a g-specific adenine glycosylase
K2I41_RS13695	COG0784	Response regulator, receiver
K2I41_RS13695	COG4191	Histidine kinase
K2I41_RS13700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2I41_RS13720	COG3040	lipid binding
K2I41_RS13730	COG1960	acyl-CoA dehydrogenase activity
K2I41_RS13740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K2I41_RS13770	COG0438	transferase activity, transferring glycosyl groups
K2I41_RS13780	COG0438	transferase activity, transferring glycosyl groups
K2I41_RS13785	COG0438	transferase activity, transferring glycosyl groups
K2I41_RS13840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K2I41_RS13855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K2I41_RS13875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K2I41_RS13890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K2I41_RS13910	COG3115	cell septum assembly
K2I41_RS13930	COG0360	Binds together with S18 to 16S ribosomal RNA
K2I41_RS13935	COG0316	Belongs to the HesB IscA family
K2I41_RS13965	COG0288	reversible hydration of carbon dioxide
K2I41_RS13980	COG3844	kynureninase activity
K2I41_RS13990	COG2925	Exonuclease
K2I41_RS14000	COG0667	Aldo Keto reductase
K2I41_RS14025	COG0116	Belongs to the methyltransferase superfamily
K2I41_RS14025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K2I41_RS14070	COG0494	nUDIX hydrolase
K2I41_RS14085	COG1024	Enoyl-CoA hydratase
K2I41_RS14095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K2I41_RS14125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K2I41_RS14130	COG0573	inorganic phosphate transmembrane transporter activity
K2I41_RS14145	COG0704	Plays a role in the regulation of phosphate uptake
K2I41_RS14155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K2I41_RS14165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2I41_RS14180	COG0557	exoribonuclease II activity
K2I41_RS14205	COG1960	acyl-CoA dehydrogenase activity
K2I41_RS14210	COG2226	methyltransferase
K2I41_RS14230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_RS14240	COG1609	Transcriptional regulator
K2I41_RS14255	COG2900	Belongs to the SlyX family
K2I41_RS14270	COG0386	Belongs to the glutathione peroxidase family
K2I41_RS14280	COG1725	Transcriptional regulator
K2I41_RS14285	COG1131	(ABC) transporter
K2I41_RS14345	COG2850	peptidyl-arginine hydroxylation
K2I41_RS14380	COG1132	(ABC) transporter
K2I41_RS14390	COG0583	DNA-binding transcription factor activity
K2I41_RS14415	COG3039	Transposase
K2I41_RS14430	COG3039	Transposase
K2I41_RS14455	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K2I41_RS14460	COG0484	heat shock protein binding
K2I41_RS14465	COG0443	Heat shock 70 kDa protein
K2I41_RS14470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K2I41_RS14480	COG0497	DNA recombination
K2I41_RS14490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_RS14495	COG2914	Belongs to the UPF0125 (RnfH) family
K2I41_RS14505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K2I41_RS14595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_RS14600	COG2311	Membrane
K2I41_RS14605	COG1047	Peptidyl-prolyl cis-trans
K2I41_RS14610	COG0791	NLP P60 protein
K2I41_RS14615	COG0791	NLP P60 protein
K2I41_RS14625	COG4106	trans-aconitate 2-methyltransferase activity
K2I41_RS14630	COG1301	dicarboxylic acid transport
K2I41_RS14635	COG1785	Belongs to the alkaline phosphatase family
K2I41_RS14640	COG0037	tRNA processing
K2I41_RS14645	COG1722	exodeoxyribonuclease VII activity
K2I41_RS14650	COG0142	geranyltranstransferase activity
K2I41_RS14655	COG4104	PAAR repeat-containing protein
K2I41_RS14675	COG0312	modulator of DNA gyrase
K2I41_RS14680	COG3028	Belongs to the UPF0307 family
K2I41_RS14685	COG0312	modulator of DNA gyrase
K2I41_RS14695	COG3164	Protein of unknown function
K2I41_RS14710	COG2968	Membrane
K2I41_RS14740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K2I41_RS14760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K2I41_RS14785	COG3118	belongs to the thioredoxin family
K2I41_RS14845	COG1132	(ABC) transporter
K2I41_RS14875	COG0745	RESPONSE REGULATOR receiver
K2I41_RS14880	COG5000	phosphorelay sensor kinase activity
K2I41_RS14880	COG5002	protein histidine kinase activity
K2I41_RS14885	COG0475	glutathione-regulated potassium exporter activity
K2I41_RS14895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K2I41_RS14915	COG1187	pseudouridine synthase activity
K2I41_RS14920	COG5001	Diguanylate cyclase
K2I41_RS14920	COG5002	protein histidine kinase activity
K2I41_RS14970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K2I41_RS15050	COG0735	belongs to the Fur family
K2I41_RS15055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K2I41_RS15095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K2I41_RS15105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K2I41_RS15120	COG0643	Histidine kinase
K2I41_RS15120	COG2198	Histidine kinase
K2I41_RS15125	COG0840	transmembrane signaling receptor activity
K2I41_RS15130	COG0835	chemotaxis
K2I41_RS15135	COG2202	Pas domain
K2I41_RS15135	COG2199	diguanylate cyclase activity
K2I41_RS15135	COG2200	EAL domain
K2I41_RS15140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K2I41_RS15155	COG3409	Peptidoglycan-binding domain 1 protein
K2I41_RS15155	COG3501	Rhs element vgr protein
K2I41_RS15205	COG3409	Peptidoglycan-binding domain 1 protein
K2I41_RS15205	COG3501	Rhs element vgr protein
K2I41_RS15225	COG1515	deoxyribonuclease V activity
K2I41_RS15235	COG1741	Belongs to the pirin family
K2I41_RS15280	COG3039	Transposase
K2I41_RS15305	COG3039	Transposase
K2I41_RS15320	COG3039	Transposase
K2I41_RS15335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_RS15345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_RS15355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_RS15375	COG1741	Belongs to the pirin family
K2I41_RS15380	COG1966	Carbon starvation protein
K2I41_RS15385	COG2879	small protein
K2I41_RS15430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K2I41_RS15435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K2I41_RS15440	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K2I41_RS15445	COG2080	2 iron, 2 sulfur cluster binding
K2I41_RS15455	COG5001	Diguanylate cyclase
K2I41_RS15455	COG4251	negative regulation of phosphorylation
K2I41_RS15455	COG3706	GGDEF domain
K2I41_RS15455	COG2203	Gaf domain
K2I41_RS15460	COG0629	single-stranded DNA binding
K2I41_RS15465	COG0142	geranyltranstransferase activity
K2I41_RS15490	COG0527	aspartate kinase activity
K2I41_RS15500	COG0384	phenazine biosynthesis protein PhzF
K2I41_RS15510	COG1764	response to oxidative stress
K2I41_RS15525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K2I41_RS15530	COG1678	Uncharacterized ACR, COG1678
K2I41_RS15545	COG0519	Catalyzes the synthesis of GMP from XMP
K2I41_RS15575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K2I41_RS15630	COG1959	2 iron, 2 sulfur cluster binding
K2I41_RS15635	COG0719	Fe-S assembly protein
K2I41_RS15640	COG0396	ATPase activity
K2I41_RS15645	COG0719	Fe-S assembly protein
K2I41_RS15650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K2I41_RS15660	COG2146	nitrite reductase [NAD(P)H] activity
K2I41_RS15675	COG1555	photosystem II stabilization
K2I41_RS15680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2I41_RS15695	COG3178	'Phosphotransferase
K2I41_RS15700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K2I41_RS15710	COG0628	permease
K2I41_RS15720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K2I41_RS15735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K2I41_RS15755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K2I41_RS15760	COG0271	Belongs to the BolA IbaG family
K2I41_RS15770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K2I41_RS15780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K2I41_RS15785	COG1137	ATPase activity
K2I41_RS15800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2I41_RS15810	COG1660	Displays ATPase and GTPase activities
K2I41_RS15820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2I41_RS15825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K2I41_RS15830	COG2239	Acts as a magnesium transporter
K2I41_RS15840	COG1294	oxidase, subunit
K2I41_RS15845	COG1271	oxidase subunit
K2I41_RS15855	COG1113	amino acid transport
K2I41_RS15870	COG2197	response regulator
K2I41_RS15875	COG0531	amino acid
K2I41_RS15930	COG0754	glutathionylspermidine amidase activity
K2I41_RS15955	COG1842	Phage shock protein A
K2I41_RS15970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K2I41_RS16000	COG3039	Transposase
K2I41_RS16015	COG3039	Transposase
K2I41_RS16030	COG3039	Transposase
K2I41_RS16075	COG3409	Peptidoglycan-binding domain 1 protein
K2I41_RS16075	COG3501	Rhs element vgr protein
K2I41_RS16080	COG3039	Transposase
K2I41_RS16195	COG3179	chitinase
K2I41_RS16355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K2I41_RS16380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K2I41_RS16395	COG2197	response regulator
K2I41_RS16400	COG4585	Histidine kinase
K2I41_RS16415	COG2894	cell division
K2I41_RS16420	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K2I41_RS16430	COG0642	Histidine kinase
K2I41_RS16435	COG0745	RESPONSE REGULATOR receiver
K2I41_RS16440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K2I41_RS16450	COG2194	sulfuric ester hydrolase activity
K2I41_RS16480	COG3551	Protein conserved in bacteria
K2I41_RS16510	COG3039	Transposase
K2I41_RS16530	COG0753	catalase activity
K2I41_RS16565	COG2207	Transcriptional regulator
K2I41_RS16565	COG1917	Cupin 2, conserved barrel domain protein
K2I41_RS16575	COG0823	Involved in the tonB-independent uptake of proteins
K2I41_RS16575	COG1506	peptidase
K2I41_RS16590	COG1297	OPT oligopeptide transporter protein
K2I41_RS16605	COG0587	DNA-directed DNA polymerase activity
K2I41_RS16690	COG0732	type I restriction modification DNA specificity domain
K2I41_RS16725	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K2I41_RS16780	COG0308	aminopeptidase N
K2I41_RS16795	COG0330	HflC and HflK could
K2I41_RS16800	COG0330	HflC and HflK could
K2I41_RS16820	COG0678	peroxiredoxin activity
K2I41_RS16880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K2I41_RS16895	COG3829	transcription factor binding
K2I41_RS16905	COG3039	Transposase
K2I41_RS16930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K2I41_RS16935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K2I41_RS16945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2I41_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS16975	COG1399	metal-binding, possibly nucleic acid-binding protein
K2I41_RS16995	COG0714	Associated with various cellular activities
K2I41_RS17015	COG0537	adenosine 5'-monophosphoramidase activity
K2I41_RS17025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K2I41_RS17045	COG0314	molybdopterin synthase activity
K2I41_RS17050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K2I41_RS17055	COG0315	cyclic pyranopterin monophosphate synthase activity
K2I41_RS17065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K2I41_RS17070	COG1234	tRNA 3'-trailer cleavage
K2I41_RS17075	COG3642	lipopolysaccharide core region biosynthetic process
K2I41_RS17080	COG0859	PFAM glycosyl transferase family 9
K2I41_RS17095	COG0631	protein serine/threonine phosphatase activity
K2I41_RS17100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K2I41_RS17125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K2I41_RS17165	COG0544	peptidyl-prolyl cis-trans isomerase activity
K2I41_RS17210	COG0473	3-isopropylmalate dehydrogenase activity
K2I41_RS17225	COG4783	chaperone-mediated protein folding
K2I41_RS17240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K2I41_RS17250	COG0438	transferase activity, transferring glycosyl groups
K2I41_RS17255	COG0671	phosphoesterase, PA-phosphatase related
K2I41_RS17260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K2I41_RS17280	COG2833	Protein of unknown function (DUF455)
K2I41_RS17300	COG0285	dihydrofolate synthase activity
K2I41_RS17305	COG0406	alpha-ribazole phosphatase activity
K2I41_RS17340	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K2I41_RS17345	COG4208	sulfate ABC transporter
K2I41_RS17350	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K2I41_RS17355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K2I41_RS17360	COG0156	8-amino-7-oxononanoate synthase activity
K2I41_RS17385	COG0604	alcohol dehydrogenase
K2I41_RS17390	COG1902	pentaerythritol trinitrate reductase activity
K2I41_RS17390	COG0446	pyridine nucleotide-disulphide oxidoreductase
K2I41_RS17420	COG0584	glycerophosphoryl diester phosphodiesterase
K2I41_RS17445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K2I41_RS17450	COG1217	gtp-binding protein TYPA
K2I41_RS17470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K2I41_RS17485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K2I41_RS17490	COG0203	ribosomal protein L17
K2I41_RS17500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K2I41_RS17505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K2I41_RS17515	COG0201	protein transport
K2I41_RS17520	COG0200	Binds to the 23S rRNA
K2I41_RS17525	COG1841	ribosomal large subunit assembly
K2I41_RS17555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K2I41_RS17560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K2I41_RS17565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K2I41_RS17570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K2I41_RS17575	COG0255	Belongs to the universal ribosomal protein uL29 family
K2I41_RS17580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K2I41_RS17590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K2I41_RS17600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K2I41_RS17605	COG0089	rRNA binding
K2I41_RS17610	COG0088	Forms part of the polypeptide exit tunnel
K2I41_RS17620	COG0051	transcription antitermination factor activity, RNA binding
K2I41_RS17640	COG0049	tRNA binding
K2I41_RS17645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K2I41_RS17650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K2I41_RS17655	COG0085	RNA polymerase activity
K2I41_RS17665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K2I41_RS17670	COG0081	regulation of translation
K2I41_RS17675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K2I41_RS17680	COG0250	Participates in transcription elongation, termination and antitermination
K2I41_RS17685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K2I41_RS17715	COG0012	GTP binding
K2I41_RS17720	COG0193	aminoacyl-tRNA hydrolase activity
K2I41_RS17730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K2I41_RS17745	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K2I41_RS17755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K2I41_RS17760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K2I41_RS17770	COG0521	Mo-molybdopterin cofactor biosynthetic process
K2I41_RS17790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K2I41_RS17795	COG1295	ribonuclease BN
K2I41_RS17830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K2I41_RS17840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K2I41_RS17895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K2I41_RS17940	COG2890	protein-(glutamine-N5) methyltransferase activity
K2I41_RS17950	COG3634	alkyl hydroperoxide reductase activity
K2I41_RS17955	COG0583	DNA-binding transcription factor activity
K2I41_RS17965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K2I41_RS17970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K2I41_RS17980	COG2197	response regulator
K2I41_RS18010	COG0697	spore germination
K2I41_RS18040	COG3386	PFAM SMP-30 Gluconolaconase
K2I41_RS18060	COG1024	Enoyl-CoA hydratase
K2I41_RS18070	COG0318	PFAM AMP-dependent synthetase and ligase
K2I41_RS18075	COG0583	DNA-binding transcription factor activity
K2I41_RS18080	COG3384	dioxygenase
K2I41_RS18110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2I41_RS18115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2I41_RS18125	COG2096	Adenosyltransferase
K2I41_RS18130	COG0123	including yeast histone deacetylase and acetoin utilization protein
K2I41_RS18145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K2I41_RS18155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K2I41_RS18160	COG2967	ApaG domain
K2I41_RS18165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K2I41_RS18185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K2I41_RS18205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K2I41_RS18220	COG0642	Histidine kinase
K2I41_RS18235	COG4181	ATPase activity
K2I41_RS18245	COG2175	clavaminate synthase activity
K2I41_RS18280	COG0667	Aldo Keto reductase
K2I41_RS18290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K2I41_RS18295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_RS18305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K2I41_RS18320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K2I41_RS18360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K2I41_RS18365	COG2226	methyltransferase
K2I41_RS18410	COG3321	synthase
K2I41_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS18410	COG0604	alcohol dehydrogenase
K2I41_RS18420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K2I41_RS18435	COG0494	nUDIX hydrolase
K2I41_RS18450	COG4942	peptidase
K2I41_RS18450	COG1388	LysM domain
K2I41_RS18460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K2I41_RS18480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K2I41_RS18485	COG1181	Belongs to the D-alanine--D-alanine ligase family
K2I41_RS18490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K2I41_RS18505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K2I41_RS18510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K2I41_RS18525	COG3116	cell division
K2I41_RS18530	COG0275	rRNA processing
K2I41_RS18570	COG0792	nuclease activity
K2I41_RS18575	COG1988	membrane-bound metal-dependent
K2I41_RS18580	COG0277	FAD linked oxidase domain protein
K2I41_RS18585	COG0745	RESPONSE REGULATOR receiver
K2I41_RS18590	COG2205	protein histidine kinase activity
K2I41_RS18600	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K2I41_RS18605	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K2I41_RS18625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K2I41_RS18630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K2I41_RS18635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K2I41_RS18655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K2I41_RS18655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K2I41_RS18665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K2I41_RS18675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2I41_RS18695	COG0488	(ABC) transporter
K2I41_RS18725	COG3791	Glutathione-dependent formaldehyde-activating
K2I41_RS18750	COG2205	protein histidine kinase activity
K2I41_RS18790	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K2I41_RS18850	COG1649	PFAM Uncharacterised BCR, COG1649
K2I41_RS18850	COG0726	polysaccharide deacetylase
K2I41_RS18855	COG1215	transferase activity, transferring glycosyl groups
K2I41_RS18865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K2I41_RS18870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2I41_RS18875	COG1609	Transcriptional regulator
K2I41_RS18885	COG2188	Transcriptional regulator
K2I41_RS18900	COG3250	beta-galactosidase activity
K2I41_RS18935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K2I41_RS18940	COG4191	Histidine kinase
K2I41_RS18945	COG0784	Response regulator, receiver
K2I41_RS18950	COG4251	negative regulation of phosphorylation
K2I41_RS18955	COG2823	Periplasmic or secreted lipoprotein
K2I41_RS18960	COG0673	inositol 2-dehydrogenase activity
K2I41_RS18965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K2I41_RS19000	COG1051	belongs to the nudix hydrolase family
K2I41_RS19000	COG1056	cytidyltransferase-related domain
K2I41_RS19025	COG2921	Belongs to the UPF0250 family
K2I41_RS19040	COG1686	Belongs to the peptidase S11 family
K2I41_RS19045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K2I41_RS19050	COG2951	lytic endotransglycosylase activity
K2I41_RS19095	COG0772	Belongs to the SEDS family
K2I41_RS19110	COG1792	Involved in formation and maintenance of cell shape
K2I41_RS19115	COG1077	Cell shape determining protein MreB Mrl
K2I41_RS19120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_RS19140	COG3300	MHYT domain
K2I41_RS19140	COG5001	Diguanylate cyclase
K2I41_RS19190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K2I41_RS19210	COG2832	Protein of unknown function (DUF454)
K2I41_RS19230	COG1505	serine-type exopeptidase activity
K2I41_RS19255	COG0181	hydroxymethylbilane synthase activity
K2I41_RS19265	COG3275	phosphorelay sensor kinase activity
K2I41_RS19295	COG0659	secondary active sulfate transmembrane transporter activity
K2I41_RS19385	COG0598	Magnesium transport protein CorA
K2I41_RS19395	COG1113	amino acid transport
K2I41_RS19415	COG4305	rare lipoprotein A
K2I41_RS19420	COG0697	spore germination
K2I41_RS19480	COG4221	oxidoreductase activity
K2I41_RS19520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K2I41_RS19545	COG0459	protein refolding
K2I41_RS19575	COG2860	membrane
K2I41_RS19580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K2I41_RS19585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K2I41_RS19590	COG2201	protein-glutamate methylesterase activity
K2I41_RS19595	COG2177	Part of the ABC transporter FtsEX involved in
K2I41_RS19600	COG2884	Cell division ATP-binding protein ftsE
K2I41_RS19610	COG3118	belongs to the thioredoxin family
K2I41_RS19615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K2I41_RS19660	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K2I41_RS19660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K2I41_RS19670	COG1473	amidohydrolase
K2I41_RS19675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_RS19680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_RS19705	COG5383	Protein conserved in bacteria
K2I41_RS19745	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K2I41_RS19750	COG3023	N-Acetylmuramoyl-L-alanine amidase
K2I41_RS19760	COG4948	Mandelate Racemase Muconate Lactonizing
K2I41_RS19775	COG0531	amino acid
K2I41_RS19795	COG4682	membrane
K2I41_RS19800	COG2133	pyrroloquinoline quinone binding
K2I41_RS19820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K2I41_RS19825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K2I41_RS19840	COG1610	YqeY-like protein
K2I41_RS19855	COG1295	ribonuclease BN
K2I41_RS19860	COG0358	DNA primase activity
K2I41_RS19915	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K2I41_RS19930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K2I41_RS19985	COG0739	heme binding
K2I41_RS20000	COG2211	Major facilitator Superfamily
K2I41_RS20005	COG0708	Exodeoxyribonuclease III
K2I41_RS20055	COG2111	Na H antiporter
K2I41_RS20055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K2I41_RS20060	COG1006	Multisubunit Na H antiporter MnhC subunit
K2I41_RS20065	COG0651	ATP synthesis coupled electron transport
K2I41_RS20075	COG2212	antiporter activity
K2I41_RS20080	COG1320	monovalent cation:proton antiporter activity
K2I41_RS20090	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K2I41_RS20115	COG3104	oligopeptide transport
K2I41_RS20120	COG3483	tryptophan 2,3-dioxygenase activity
K2I41_RS20130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K2I41_RS20145	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2I41_RS20155	COG3039	Transposase
K2I41_RS20160	COG0513	Belongs to the DEAD box helicase family
K2I41_RS20275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K2I41_RS20280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K2I41_RS20290	COG0045	succinate-CoA ligase (ADP-forming) activity
K2I41_RS20290	COG1042	CoA-binding domain protein
K2I41_RS20290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2I41_RS20300	COG2239	Acts as a magnesium transporter
K2I41_RS20325	COG3039	Transposase
K2I41_RS20330	COG3039	Transposase
K2I41_RS20355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K2I41_RS20385	COG3100	YcgL domain-containing protein
K2I41_RS20390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2I41_RS20400	COG0463	Glycosyl transferase, family 2
K2I41_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS20475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2I41_RS20520	COG0408	coproporphyrinogen oxidase activity
K2I41_RS20595	COG0210	DNA helicase
K2I41_RS20610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K2I41_RS20615	COG0583	DNA-binding transcription factor activity
K2I41_RS20620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K2I41_RS20630	COG2159	amidohydrolase
K2I41_RS20655	COG0357	Ribosomal RNA small subunit methyltransferase G
K2I41_RS20660	COG3540	Alkaline phosphatase
K2I41_RS20670	COG2091	lysine biosynthetic process via aminoadipic acid
K2I41_RS20685	COG0708	Exodeoxyribonuclease III
K2I41_RS20700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K2I41_RS20705	COG3162	membrane
K2I41_RS20745	COG1414	Transcriptional regulator
K2I41_RS20755	COG2205	protein histidine kinase activity
K2I41_RS20765	COG3459	Glycosyltransferase 36 associated
K2I41_RS20775	COG3265	gluconokinase activity
K2I41_RS20780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_RS20785	COG3039	Transposase
K2I41_RS20800	COG0339	signal peptide processing
K2I41_RS20830	COG0564	pseudouridine synthase activity
K2I41_RS20845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K2I41_RS20855	COG1181	Belongs to the D-alanine--D-alanine ligase family
K2I41_RS20865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K2I41_RS20870	COG0318	PFAM AMP-dependent synthetase and ligase
K2I41_RS20875	COG0727	PFAM Uncharacterised protein family (UPF0153)
K2I41_RS20880	COG0596	Alpha beta hydrolase
K2I41_RS20885	COG3177	Filamentation induced by cAMP protein fic
K2I41_RS20890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2I41_RS20905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K2I41_RS20930	COG4191	Histidine kinase
K2I41_RS20935	COG0028	Belongs to the TPP enzyme family
K2I41_RS20950	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K2I41_RS20955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K2I41_RS21000	COG0183	Belongs to the thiolase family
K2I41_RS21030	COG3039	Transposase
K2I41_RS21055	COG2032	superoxide dismutase activity
K2I41_RS21060	COG2032	superoxide dismutase activity
K2I41_RS21065	COG2204	response regulator
K2I41_RS21070	COG3852	Histidine kinase
K2I41_RS21075	COG0004	ammonium transporteR
K2I41_RS21080	COG0347	Belongs to the P(II) protein family
K2I41_RS21085	COG0174	glutamine synthetase
K2I41_RS21090	COG1968	undecaprenyl-diphosphatase activity
K2I41_RS21135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K2I41_RS21145	COG2062	phosphohistidine phosphatase, SixA
K2I41_RS21150	COG0489	protein tyrosine kinase activity
K2I41_RS21170	COG1396	sequence-specific DNA binding
K2I41_RS21175	COG3550	peptidyl-serine autophosphorylation
K2I41_RS21180	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K2I41_RS21185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_RS21200	COG1125	glycine betaine transport
K2I41_RS21200	COG0517	IMP dehydrogenase activity
K2I41_RS21215	COG1119	ATPase activity
K2I41_RS21225	COG1473	amidohydrolase
K2I41_RS21230	COG1752	Esterase of the alpha-beta hydrolase superfamily
K2I41_RS21240	COG1522	sequence-specific DNA binding
K2I41_RS21245	COG3186	Phenylalanine-4-hydroxylase
K2I41_RS21260	COG2755	lipolytic protein G-D-S-L family
K2I41_RS21270	COG1609	Transcriptional regulator
K2I41_RS21295	COG0366	Alpha amylase catalytic
K2I41_RS21300	COG0366	Alpha amylase catalytic
K2I41_RS21315	COG3039	Transposase
K2I41_RS21345	COG3039	Transposase
K2I41_RS21350	COG3210	domain, Protein
K2I41_RS21410	COG3135	benzoate transporter
K2I41_RS21430	COG0676	glucose-6-phosphate 1-epimerase activity
K2I41_RS21485	COG0302	gtp cyclohydrolase
K2I41_RS21515	COG0477	Major facilitator Superfamily
K2I41_RS21560	COG3237	CsbD-like
K2I41_RS21650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_RS21665	COG3039	Transposase
K2I41_RS21690	COG1755	Isoprenylcysteine carboxyl methyltransferase
K2I41_RS21695	COG1304	FMN binding
K2I41_RS21710	COG4772	TonB-dependent receptor
K2I41_RS21720	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K2I41_RS21745	COG1272	protein, Hemolysin III
K2I41_RS21750	COG1111	helicase
K2I41_RS21750	COG1205	dead DEAH box helicase
K2I41_RS21810	COG0070	glutamate synthase
K2I41_RS21810	COG0069	glutamate synthase activity
K2I41_RS21810	COG0067	glutamate synthase
K2I41_RS21815	COG0493	'glutamate synthase
K2I41_RS21825	COG0531	amino acid
K2I41_RS21835	COG1322	Protein conserved in bacteria
K2I41_RS21845	COG0386	Belongs to the glutathione peroxidase family
K2I41_RS21850	COG2853	Lipoprotein
K2I41_RS21865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K2I41_RS21870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K2I41_RS21875	COG1127	ABC transporter
K2I41_RS21910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K2I41_RS21915	COG1074	ATP-dependent DNA helicase activity
K2I41_RS21920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K2I41_RS22000	COG2124	cytochrome p450
K2I41_RS22005	COG2124	cytochrome p450
K2I41_RS22010	COG1141	Ferredoxin
K2I41_RS22015	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_RS22020	COG2124	cytochrome p450
K2I41_RS22025	COG0142	geranyltranstransferase activity
K2I41_RS22030	COG1657	PFAM Prenyltransferase squalene oxidase
K2I41_RS22040	COG1304	FMN binding
K2I41_RS22055	COG0564	pseudouridine synthase activity
K2I41_RS22080	COG3706	GGDEF domain
K2I41_RS22090	COG1929	Belongs to the glycerate kinase type-1 family
K2I41_RS22095	COG2271	Major facilitator Superfamily
K2I41_RS22110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K2I41_RS22115	COG0861	Integral membrane protein TerC family
K2I41_RS22125	COG0584	glycerophosphoryl diester phosphodiesterase
K2I41_RS22135	COG0671	phosphoesterase, PA-phosphatase related
K2I41_RS22140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K2I41_RS22145	COG0726	polysaccharide deacetylase
K2I41_RS22235	COG0784	Response regulator, receiver
K2I41_RS22235	COG0643	Histidine kinase
K2I41_RS22235	COG2198	Histidine kinase
K2I41_RS22285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein