locus-tag	class	description
H4J00_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4J00_RS00020	COG0187	DNA topoisomerase II activity
H4J00_RS00030	COG0501	Belongs to the peptidase M48B family
H4J00_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H4J00_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4J00_RS00085	COG1064	alcohol dehydrogenase
H4J00_RS00090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_RS00100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_RS00115	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_RS00125	COG2234	aminopeptidase activity
H4J00_RS00135	COG4942	peptidase
H4J00_RS00140	COG0793	Belongs to the peptidase S41A family
H4J00_RS00185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4J00_RS00205	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H4J00_RS00220	COG0210	DNA helicase
H4J00_RS00240	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H4J00_RS00245	COG0284	orotidine-5'-phosphate decarboxylase activity
H4J00_RS00275	COG2937	Belongs to the GPAT DAPAT family
H4J00_RS00280	COG0604	alcohol dehydrogenase
H4J00_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS00280	COG3321	synthase
H4J00_RS00320	COG2211	Major facilitator Superfamily
H4J00_RS00340	COG3693	PFAM glycoside hydrolase, family 10
H4J00_RS00375	COG4770	biotin carboxylase activity
H4J00_RS00380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4J00_RS00385	COG1960	acyl-CoA dehydrogenase activity
H4J00_RS00440	COG0523	cobalamin synthesis protein
H4J00_RS00465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4J00_RS00470	COG1846	Transcriptional regulator
H4J00_RS00475	COG1764	response to oxidative stress
H4J00_RS00505	COG0656	L-ascorbic acid biosynthetic process
H4J00_RS00510	COG2130	NADP-dependent
H4J00_RS00515	COG0667	Aldo Keto reductase
H4J00_RS00525	COG1187	pseudouridine synthase activity
H4J00_RS00535	COG1643	Atp-dependent helicase
H4J00_RS00545	COG4807	Protein conserved in bacteria
H4J00_RS00550	COG2351	hydroxyisourate hydrolase activity
H4J00_RS00575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H4J00_RS00585	COG0583	DNA-binding transcription factor activity
H4J00_RS00600	COG0129	dihydroxy-acid dehydratase activity
H4J00_RS00610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4J00_RS00680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4J00_RS00685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4J00_RS00695	COG3485	protocatechuate 3,4-dioxygenase
H4J00_RS00700	COG3485	protocatechuate 3,4-dioxygenase
H4J00_RS00715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4J00_RS00720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4J00_RS00735	COG1414	Transcriptional regulator
H4J00_RS00745	COG0657	acetylesterase activity
H4J00_RS00815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4J00_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS00855	COG0156	8-amino-7-oxononanoate synthase activity
H4J00_RS00860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4J00_RS00865	COG1040	competence protein
H4J00_RS00870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4J00_RS00895	COG2911	Protein conserved in bacteria
H4J00_RS00900	COG0729	surface antigen
H4J00_RS00905	COG4771	TonB-dependent receptor
H4J00_RS00915	COG0457	Tetratricopeptide repeat
H4J00_RS00925	COG0752	glycyl-tRNA synthetase alpha subunit
H4J00_RS00930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4J00_RS00940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4J00_RS00940	COG0519	Catalyzes the synthesis of GMP from XMP
H4J00_RS00950	COG0805	protein transport
H4J00_RS00955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4J00_RS00960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4J00_RS00970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4J00_RS00995	COG2974	May be involved in recombination
H4J00_RS01020	COG3661	Belongs to the glycosyl hydrolase 67 family
H4J00_RS01030	COG4948	Mandelate Racemase Muconate Lactonizing
H4J00_RS01040	COG1472	Belongs to the glycosyl hydrolase 3 family
H4J00_RS01045	COG0246	Mannitol dehydrogenase
H4J00_RS01135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4J00_RS01210	COG1511	domain protein
H4J00_RS01210	COG3264	Mechanosensitive ion channel
H4J00_RS01225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4J00_RS01230	COG2354	Protein conserved in bacteria
H4J00_RS01235	COG1649	PFAM Uncharacterised BCR, COG1649
H4J00_RS01255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4J00_RS01280	COG0702	epimerase
H4J00_RS01290	COG3039	Transposase
H4J00_RS01295	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS01310	COG3039	Transposase
H4J00_RS01325	COG3039	Transposase
H4J00_RS01360	COG3409	Peptidoglycan-binding domain 1 protein
H4J00_RS01360	COG3501	Rhs element vgr protein
H4J00_RS01440	COG0084	hydrolase, TatD family'
H4J00_RS01460	COG2814	Major facilitator Superfamily
H4J00_RS01470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4J00_RS01475	COG1902	pentaerythritol trinitrate reductase activity
H4J00_RS01505	COG0745	RESPONSE REGULATOR receiver
H4J00_RS01525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4J00_RS01530	COG0583	DNA-binding transcription factor activity
H4J00_RS01555	COG1733	regulation of RNA biosynthetic process
H4J00_RS01560	COG0702	epimerase
H4J00_RS01600	COG0583	DNA-binding transcription factor activity
H4J00_RS01640	COG1199	ATP-dependent helicase activity
H4J00_RS01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4J00_RS01695	COG3228	Belongs to the MtfA family
H4J00_RS01705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H4J00_RS01705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H4J00_RS01710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4J00_RS01725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H4J00_RS01765	COG0180	Tryptophanyl-tRNA synthetase
H4J00_RS01770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4J00_RS01815	COG0753	catalase activity
H4J00_RS01830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4J00_RS01865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4J00_RS01885	COG1090	epimerase
H4J00_RS01915	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS01935	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4J00_RS01955	COG0606	chelatase, subunit chli
H4J00_RS02040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4J00_RS02045	COG1166	arginine decarboxylase activity
H4J00_RS02065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H4J00_RS02065	COG2755	lipolytic protein G-D-S-L family
H4J00_RS02070	COG4221	oxidoreductase activity
H4J00_RS02095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4J00_RS02120	COG0463	Glycosyl transferase, family 2
H4J00_RS02135	COG1475	DNA binding
H4J00_RS02140	COG1192	Involved in chromosome partitioning
H4J00_RS02170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H4J00_RS02180	COG0456	acetyltransferase
H4J00_RS02215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4J00_RS02220	COG0134	indole-3-glycerol-phosphate synthase activity
H4J00_RS02230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4J00_RS02235	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4J00_RS02245	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H4J00_RS02255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4J00_RS02325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4J00_RS02340	COG2814	Major facilitator Superfamily
H4J00_RS02355	COG1289	transmembrane transporter activity
H4J00_RS02365	COG0577	efflux transmembrane transporter activity
H4J00_RS02365	COG1136	(ABC) transporter
H4J00_RS02370	COG0151	Belongs to the GarS family
H4J00_RS02375	COG0138	bifunctional purine biosynthesis protein purh
H4J00_RS02400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H4J00_RS02440	COG0439	Biotin carboxylase
H4J00_RS02450	COG0511	ligase activity, forming carbon-carbon bonds
H4J00_RS02455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4J00_RS02470	COG1324	tolerance protein
H4J00_RS02475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4J00_RS02495	COG0534	Mate efflux family protein
H4J00_RS02500	COG0616	signal peptide processing
H4J00_RS02510	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS02525	COG0009	L-threonylcarbamoyladenylate synthase
H4J00_RS02530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4J00_RS02530	COG1754	DNA topoisomerase type I activity
H4J00_RS02550	COG0758	DNA mediated transformation
H4J00_RS02560	COG0242	peptide deformylase activity
H4J00_RS02565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4J00_RS02570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4J00_RS02570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4J00_RS02615	COG1560	Kdo2-lipid A biosynthetic process
H4J00_RS02625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4J00_RS02665	COG0625	glutathione transferase activity
H4J00_RS02700	COG4555	ABC transporter
H4J00_RS02710	COG1476	TRANSCRIPTIONal
H4J00_RS02730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4J00_RS02735	COG1131	(ABC) transporter
H4J00_RS02740	COG0842	Transport permease protein
H4J00_RS02750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4J00_RS02770	COG3039	Transposase
H4J00_RS02780	COG2951	lytic endotransglycosylase activity
H4J00_RS02800	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS02815	COG3039	Transposase
H4J00_RS02820	COG3210	domain, Protein
H4J00_RS02900	COG2353	YceI-like domain
H4J00_RS02930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4J00_RS02990	COG3039	Transposase
H4J00_RS03035	COG1063	alcohol dehydrogenase
H4J00_RS03065	COG1294	oxidase, subunit
H4J00_RS03070	COG1271	oxidase subunit
H4J00_RS03105	COG2972	Histidine kinase
H4J00_RS03120	COG0531	amino acid
H4J00_RS03140	COG3590	peptidase
H4J00_RS03150	COG0667	Aldo Keto reductase
H4J00_RS03165	COG3384	dioxygenase
H4J00_RS03175	COG1573	uracil-dna glycosylase
H4J00_RS03185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4J00_RS03190	COG0025	NhaP-type Na H and K H
H4J00_RS03195	COG1131	(ABC) transporter
H4J00_RS03200	COG0842	Transport permease protein
H4J00_RS03215	COG1404	Belongs to the peptidase S8 family
H4J00_RS03230	COG0745	RESPONSE REGULATOR receiver
H4J00_RS03280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_RS03305	COG2202	Pas domain
H4J00_RS03305	COG2205	protein histidine kinase activity
H4J00_RS03340	COG2813	Specifically methylates the guanine in position
H4J00_RS03345	COG1187	pseudouridine synthase activity
H4J00_RS03350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4J00_RS03385	COG0697	spore germination
H4J00_RS03395	COG2011	ABC-type metal ion transport system permease component
H4J00_RS03430	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4J00_RS03440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4J00_RS03460	COG0356	it plays a direct role in the translocation of protons across the membrane
H4J00_RS03470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4J00_RS03480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4J00_RS03485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4J00_RS03490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4J00_RS03515	COG4191	Histidine kinase
H4J00_RS03525	COG1136	(ABC) transporter
H4J00_RS03525	COG0577	efflux transmembrane transporter activity
H4J00_RS03530	COG1136	(ABC) transporter
H4J00_RS03530	COG0577	efflux transmembrane transporter activity
H4J00_RS03545	COG1136	(ABC) transporter
H4J00_RS03550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_RS03555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4J00_RS03605	COG0339	signal peptide processing
H4J00_RS03630	COG0546	phosphoglycolate phosphatase activity
H4J00_RS03640	COG1956	GAF domain-containing protein
H4J00_RS03645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4J00_RS03655	COG0720	synthase
H4J00_RS03660	COG0513	Belongs to the DEAD box helicase family
H4J00_RS03670	COG0625	glutathione transferase activity
H4J00_RS03700	COG0626	cystathionine gamma-synthase activity
H4J00_RS03715	COG0110	maltose O-acetyltransferase activity
H4J00_RS03720	COG0438	transferase activity, transferring glycosyl groups
H4J00_RS03720	COG1216	Glycosyl transferase, family 2
H4J00_RS03725	COG3754	Rhamnan synthesis protein F
H4J00_RS03735	COG2226	methyltransferase
H4J00_RS03755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4J00_RS03770	COG0277	FAD linked oxidase domain protein
H4J00_RS03775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4J00_RS03775	COG0546	phosphoglycolate phosphatase activity
H4J00_RS03790	COG2086	electron transfer activity
H4J00_RS03815	COG0662	Cupin 2, conserved barrel domain protein
H4J00_RS03815	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H4J00_RS03820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4J00_RS03855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4J00_RS03855	COG3218	ABC-type transport auxiliary lipoprotein component
H4J00_RS03860	COG1127	ABC transporter
H4J00_RS03865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4J00_RS03880	COG0442	prolyl-tRNA aminoacylation
H4J00_RS03890	COG1183	phosphatidylcholine synthase activity
H4J00_RS03920	COG0525	valine-tRNA ligase activity
H4J00_RS03935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4J00_RS03945	COG0795	lipopolysaccharide-transporting ATPase activity
H4J00_RS03960	COG4974	Belongs to the 'phage' integrase family
H4J00_RS03965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4J00_RS03970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4J00_RS03970	COG0047	phosphoribosylformylglycinamidine synthase activity
H4J00_RS03975	COG5295	Hep Hag repeat protein
H4J00_RS03980	COG1404	Belongs to the peptidase S8 family
H4J00_RS03985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4J00_RS03995	COG1459	type II secretion system
H4J00_RS04000	COG2165	general secretion pathway protein
H4J00_RS04005	COG4970	Tfp pilus assembly protein FimT
H4J00_RS04010	COG2165	general secretion pathway protein
H4J00_RS04015	COG4795	General secretion pathway protein
H4J00_RS04020	COG3156	type II secretion system protein K
H4J00_RS04025	COG3166	PFAM Fimbrial assembly family protein
H4J00_RS04040	COG1450	Type ii and iii secretion system protein
H4J00_RS04055	COG2188	Transcriptional regulator
H4J00_RS04105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H4J00_RS04115	COG3039	Transposase
H4J00_RS04135	COG0242	peptide deformylase activity
H4J00_RS04170	COG0402	S-adenosylhomocysteine deaminase activity
H4J00_RS04175	COG3964	amidohydrolase
H4J00_RS04195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4J00_RS04200	COG0726	polysaccharide deacetylase
H4J00_RS04220	COG0436	Aminotransferase
H4J00_RS04250	COG2211	Major facilitator Superfamily
H4J00_RS04260	COG1609	Transcriptional regulator
H4J00_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS04270	COG2851	Citrate transporter
H4J00_RS04285	COG0642	Histidine kinase
H4J00_RS04295	COG2197	response regulator
H4J00_RS04315	COG0583	DNA-binding transcription factor activity
H4J00_RS04330	COG4191	Histidine kinase
H4J00_RS04345	COG0281	malic enzyme
H4J00_RS04345	COG0280	phosphate acetyltransferase
H4J00_RS04370	COG1560	Kdo2-lipid A biosynthetic process
H4J00_RS04375	COG1519	Transferase
H4J00_RS04380	COG3039	Transposase
H4J00_RS04385	COG1538	Outer membrane efflux protein
H4J00_RS04390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4J00_RS04410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4J00_RS04415	COG0066	3-isopropylmalate dehydratase activity
H4J00_RS04420	COG2226	methyltransferase
H4J00_RS04450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4J00_RS04460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4J00_RS04465	COG3710	Transcriptional regulator
H4J00_RS04490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4J00_RS04500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H4J00_RS04535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4J00_RS04545	COG3781	membrane
H4J00_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS04580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4J00_RS04585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4J00_RS04635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4J00_RS04645	COG0352	thiamine-phosphate diphosphorylase activity
H4J00_RS04650	COG1773	rubredoxin
H4J00_RS04655	COG2912	Transglutaminase-like superfamily
H4J00_RS04675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4J00_RS04700	COG0006	proline dipeptidase activity
H4J00_RS04730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4J00_RS04740	COG0346	lactoylglutathione lyase activity
H4J00_RS04745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4J00_RS04750	COG1561	YicC-like family, N-terminal region
H4J00_RS04770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4J00_RS04780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4J00_RS04810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H4J00_RS04845	COG0714	Associated with various cellular activities
H4J00_RS04865	COG2304	oxidoreductase activity
H4J00_RS04900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4J00_RS05000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4J00_RS05005	COG4149	molybdate abc transporter
H4J00_RS05010	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4J00_RS05015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4J00_RS05015	COG3453	Protein conserved in bacteria
H4J00_RS05025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4J00_RS05040	COG0126	phosphoglycerate kinase activity
H4J00_RS05050	COG0469	pyruvate kinase activity
H4J00_RS05055	COG3588	fructose-bisphosphate aldolase
H4J00_RS05060	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H4J00_RS05075	COG1648	precorrin-2 dehydrogenase activity
H4J00_RS05075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4J00_RS05100	COG0784	Response regulator, receiver
H4J00_RS05100	COG2198	Histidine kinase
H4J00_RS05100	COG2205	protein histidine kinase activity
H4J00_RS05120	COG0175	sulfate reduction
H4J00_RS05125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4J00_RS05130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4J00_RS05135	COG0175	sulfate reduction
H4J00_RS05140	COG2895	sulfate adenylyltransferase (ATP) activity
H4J00_RS05140	COG0529	Catalyzes the synthesis of activated sulfate
H4J00_RS05150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_RS05155	COG0308	aminopeptidase N
H4J00_RS05185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4J00_RS05210	COG1970	mechanosensitive ion channel activity
H4J00_RS05235	COG0471	metal ion transport
H4J00_RS05235	COG3273	potassium ion transport
H4J00_RS05245	COG2022	thiamine diphosphate biosynthetic process
H4J00_RS05265	COG3039	Transposase
H4J00_RS05285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4J00_RS05295	COG2003	Belongs to the UPF0758 family
H4J00_RS05330	COG0084	hydrolase, TatD family'
H4J00_RS05350	COG3039	Transposase
H4J00_RS05405	COG0745	RESPONSE REGULATOR receiver
H4J00_RS05435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H4J00_RS05445	COG4969	Belongs to the N-Me-Phe pilin family
H4J00_RS05450	COG2194	sulfuric ester hydrolase activity
H4J00_RS05490	COG0045	succinate-CoA ligase (ADP-forming) activity
H4J00_RS05495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4J00_RS05510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4J00_RS05510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4J00_RS05515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_RS05520	COG0564	pseudouridine synthase activity
H4J00_RS05535	COG3011	Protein conserved in bacteria
H4J00_RS05540	COG0840	transmembrane signaling receptor activity
H4J00_RS05555	COG3387	PFAM Glycoside hydrolase 15-related
H4J00_RS05560	COG1877	trehalose-phosphatase activity
H4J00_RS05600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H4J00_RS05625	COG1946	Acyl-CoA thioesterase
H4J00_RS05640	COG0824	Thioesterase
H4J00_RS05645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4J00_RS05655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4J00_RS05660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4J00_RS05665	COG0268	Binds directly to 16S ribosomal RNA
H4J00_RS05670	COG0728	peptidoglycan biosynthetic process
H4J00_RS05675	COG0196	riboflavin kinase activity
H4J00_RS05685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4J00_RS05690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4J00_RS05705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4J00_RS05710	COG1845	cytochrome c oxidase, subunit III
H4J00_RS05715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4J00_RS05735	COG3209	COG3209 Rhs family protein
H4J00_RS05750	COG3209	COG3209 Rhs family protein
H4J00_RS05770	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS05780	COG3039	Transposase
H4J00_RS05825	COG2207	Transcriptional regulator
H4J00_RS05830	COG0326	Molecular chaperone. Has ATPase activity
H4J00_RS05840	COG1366	Belongs to the anti-sigma-factor antagonist family
H4J00_RS05845	COG1366	Belongs to the anti-sigma-factor antagonist family
H4J00_RS05850	COG2172	sigma factor antagonist activity
H4J00_RS05890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4J00_RS05895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4J00_RS05905	COG2070	2-Nitropropane dioxygenase
H4J00_RS05915	COG0228	four-way junction DNA binding
H4J00_RS05920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4J00_RS05925	COG0336	Belongs to the RNA methyltransferase TrmD family
H4J00_RS05940	COG0534	Mate efflux family protein
H4J00_RS05950	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H4J00_RS05975	COG0542	response to heat
H4J00_RS06035	COG0019	diaminopimelate decarboxylase activity
H4J00_RS06045	COG2814	Major facilitator Superfamily
H4J00_RS06050	COG4264	IucA IucC family
H4J00_RS06060	COG4772	TonB-dependent receptor
H4J00_RS06075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4J00_RS06075	COG4651	solute:proton antiporter activity
H4J00_RS06105	COG0488	(ABC) transporter
H4J00_RS06130	COG0657	acetylesterase activity
H4J00_RS06130	COG2755	lipolytic protein G-D-S-L family
H4J00_RS06145	COG0477	Major facilitator Superfamily
H4J00_RS06160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4J00_RS06195	COG2255	four-way junction helicase activity
H4J00_RS06200	COG0824	Thioesterase
H4J00_RS06220	COG0823	Involved in the tonB-independent uptake of proteins
H4J00_RS06225	COG2885	chlorophyll binding
H4J00_RS06235	COG0602	queuosine metabolic process
H4J00_RS06245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4J00_RS06285	COG4695	Portal protein
H4J00_RS06330	COG3179	chitinase
H4J00_RS06505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4J00_RS06535	COG1187	pseudouridine synthase activity
H4J00_RS06550	COG0514	ATP-dependent DNA helicase (RecQ)
H4J00_RS06555	COG0783	Belongs to the Dps family
H4J00_RS06560	COG1643	Atp-dependent helicase
H4J00_RS06610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4J00_RS06620	COG1215	transferase activity, transferring glycosyl groups
H4J00_RS06625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4J00_RS06635	COG1199	ATP-dependent helicase activity
H4J00_RS06655	COG0189	ligase activity
H4J00_RS06670	COG0835	chemotaxis
H4J00_RS06675	COG0840	transmembrane signaling receptor activity
H4J00_RS06680	COG0643	Histidine kinase
H4J00_RS06680	COG0784	Response regulator, receiver
H4J00_RS06680	COG2198	Histidine kinase
H4J00_RS06705	COG2304	oxidoreductase activity
H4J00_RS06710	COG1446	asparaginase
H4J00_RS06755	COG3537	Alpha-1,2-mannosidase
H4J00_RS06770	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS06785	COG1472	Belongs to the glycosyl hydrolase 3 family
H4J00_RS06795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H4J00_RS06800	COG1388	LysM domain
H4J00_RS06800	COG3858	chitin binding
H4J00_RS06815	COG0837	glucose binding
H4J00_RS06820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4J00_RS06830	COG0494	nUDIX hydrolase
H4J00_RS06840	COG3956	TIGRFAM MazG family protein
H4J00_RS06845	COG1742	UPF0060 membrane protein
H4J00_RS06855	COG0330	HflC and HflK could
H4J00_RS06870	COG0509	glycine decarboxylation via glycine cleavage system
H4J00_RS06900	COG1960	acyl-CoA dehydrogenase activity
H4J00_RS06910	COG1309	transcriptional regulator
H4J00_RS06915	COG4771	TonB-dependent receptor
H4J00_RS06925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H4J00_RS06935	COG0463	Glycosyl transferase, family 2
H4J00_RS06940	COG0516	GMP reductase activity
H4J00_RS06940	COG0517	IMP dehydrogenase activity
H4J00_RS06955	COG1272	protein, Hemolysin III
H4J00_RS06965	COG0739	heme binding
H4J00_RS06970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4J00_RS06975	COG0626	cystathionine gamma-synthase activity
H4J00_RS06985	COG1760	l-serine dehydratase
H4J00_RS07010	COG2353	YceI-like domain
H4J00_RS07015	COG0784	Response regulator, receiver
H4J00_RS07015	COG2198	Histidine kinase
H4J00_RS07015	COG2205	protein histidine kinase activity
H4J00_RS07020	COG0784	Response regulator, receiver
H4J00_RS07020	COG5002	protein histidine kinase activity
H4J00_RS07085	COG1960	acyl-CoA dehydrogenase activity
H4J00_RS07110	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4J00_RS07110	COG1024	Enoyl-CoA hydratase
H4J00_RS07125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4J00_RS07130	COG0481	GTPase activity
H4J00_RS07135	COG0681	Belongs to the peptidase S26 family
H4J00_RS07155	COG1381	Involved in DNA repair and RecF pathway recombination
H4J00_RS07170	COG2954	triphosphatase activity
H4J00_RS07175	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4J00_RS07180	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H4J00_RS07185	COG3046	protein related to deoxyribodipyrimidine photolyase
H4J00_RS07195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H4J00_RS07200	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H4J00_RS07205	COG1278	Cold shock
H4J00_RS07225	COG1201	RNA secondary structure unwinding
H4J00_RS07230	COG1793	dna ligase
H4J00_RS07240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4J00_RS07240	COG1793	dna ligase
H4J00_RS07255	COG3706	GGDEF domain
H4J00_RS07270	COG0183	Belongs to the thiolase family
H4J00_RS07295	COG1451	nucleotide metabolic process
H4J00_RS07310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4J00_RS07360	COG1047	Peptidyl-prolyl cis-trans
H4J00_RS07370	COG2824	Alkylphosphonate utilization operon protein PhnA
H4J00_RS07380	COG1902	pentaerythritol trinitrate reductase activity
H4J00_RS07385	COG2814	Major facilitator Superfamily
H4J00_RS07420	COG0392	lysyltransferase activity
H4J00_RS07420	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H4J00_RS07430	COG0251	oxidation-reduction process
H4J00_RS07435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4J00_RS07450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4J00_RS07475	COG1595	DNA-templated transcription, initiation
H4J00_RS07490	COG2878	Part of a membrane complex involved in electron transport
H4J00_RS07500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4J00_RS07500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4J00_RS07510	COG0346	lactoylglutathione lyase activity
H4J00_RS07515	COG0833	amino acid
H4J00_RS07520	COG2040	homocysteine
H4J00_RS07535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4J00_RS07555	COG1695	Transcriptional regulator
H4J00_RS07580	COG1981	membrane
H4J00_RS07605	COG0825	malonyl-CoA metabolic process
H4J00_RS07625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4J00_RS07630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4J00_RS07635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4J00_RS07640	COG3039	Transposase
H4J00_RS07650	COG0750	zinc metalloprotease
H4J00_RS07655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4J00_RS07660	COG0575	Belongs to the CDS family
H4J00_RS07670	COG0233	cytoplasmic translational termination
H4J00_RS07685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4J00_RS07745	COG1393	Belongs to the ArsC family
H4J00_RS07755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4J00_RS07760	COG0367	asparagine synthase
H4J00_RS07770	COG4774	siderophore transport
H4J00_RS07790	COG2207	Transcriptional regulator
H4J00_RS07805	COG1566	PFAM secretion protein HlyD family protein
H4J00_RS07810	COG2814	Major facilitator Superfamily
H4J00_RS07880	COG1595	DNA-templated transcription, initiation
H4J00_RS07920	COG0386	Belongs to the glutathione peroxidase family
H4J00_RS07990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4J00_RS07995	COG0084	hydrolase, TatD family'
H4J00_RS08010	COG1960	acyl-CoA dehydrogenase activity
H4J00_RS08025	COG0367	asparagine synthase
H4J00_RS08035	COG0305	Participates in initiation and elongation during chromosome replication
H4J00_RS08040	COG0415	Belongs to the DNA photolyase family
H4J00_RS08075	COG3706	GGDEF domain
H4J00_RS08090	COG0489	protein tyrosine kinase activity
H4J00_RS08095	COG0717	Belongs to the dCTP deaminase family
H4J00_RS08120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4J00_RS08135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4J00_RS08155	COG0433	COG0433 Predicted ATPase
H4J00_RS08180	COG2890	protein-(glutamine-N5) methyltransferase activity
H4J00_RS08185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4J00_RS08190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4J00_RS08195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4J00_RS08215	COG0101	tRNA pseudouridine synthase activity
H4J00_RS08220	COG0135	phosphoribosylanthranilate isomerase activity
H4J00_RS08230	COG0133	tryptophan synthase activity
H4J00_RS08245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4J00_RS08250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4J00_RS08290	COG0149	triose-phosphate isomerase activity
H4J00_RS08305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4J00_RS08315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4J00_RS08320	COG0649	NAD binding
H4J00_RS08325	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H4J00_RS08330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4J00_RS08335	COG1034	ATP synthesis coupled electron transport
H4J00_RS08340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4J00_RS08370	COG1007	ATP synthesis coupled electron transport
H4J00_RS08380	COG0779	Required for maturation of 30S ribosomal subunits
H4J00_RS08385	COG0195	Participates in both transcription termination and antitermination
H4J00_RS08390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H4J00_RS08405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4J00_RS08410	COG1185	polyribonucleotide nucleotidyltransferase activity
H4J00_RS08445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4J00_RS08455	COG2095	MarC family integral membrane protein
H4J00_RS08470	COG1611	Belongs to the LOG family
H4J00_RS08565	COG4974	Belongs to the 'phage' integrase family
H4J00_RS08570	COG4969	Belongs to the N-Me-Phe pilin family
H4J00_RS08575	COG0556	nucleotide-excision repair
H4J00_RS08590	COG2201	protein-glutamate methylesterase activity
H4J00_RS08625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H4J00_RS08635	COG2986	histidine ammonia-lyase
H4J00_RS08640	COG1228	amidohydrolase
H4J00_RS08680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4J00_RS08685	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4J00_RS08690	COG0077	Prephenate dehydratase
H4J00_RS08690	COG1605	Chorismate mutase
H4J00_RS08695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4J00_RS08715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H4J00_RS08720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4J00_RS08725	COG0583	DNA-binding transcription factor activity
H4J00_RS08765	COG3039	Transposase
H4J00_RS08800	COG0840	transmembrane signaling receptor activity
H4J00_RS08815	COG0784	Response regulator, receiver
H4J00_RS08815	COG2205	protein histidine kinase activity
H4J00_RS08815	COG5002	protein histidine kinase activity
H4J00_RS08820	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H4J00_RS08840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4J00_RS08860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4J00_RS08875	COG1595	DNA-templated transcription, initiation
H4J00_RS08925	COG2244	polysaccharide biosynthetic process
H4J00_RS08955	COG2264	protein methyltransferase activity
H4J00_RS08965	COG0438	transferase activity, transferring glycosyl groups
H4J00_RS08985	COG1132	(ABC) transporter
H4J00_RS08995	COG0477	Major facilitator Superfamily
H4J00_RS09005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4J00_RS09020	COG1253	flavin adenine dinucleotide binding
H4J00_RS09055	COG0504	CTP synthase activity
H4J00_RS09060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H4J00_RS09070	COG0148	phosphopyruvate hydratase activity
H4J00_RS09075	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H4J00_RS09090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4J00_RS09105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H4J00_RS09110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4J00_RS09115	COG1238	metal cluster binding
H4J00_RS09130	COG1534	Rna-binding protein
H4J00_RS09135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H4J00_RS09145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4J00_RS09160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4J00_RS09165	COG1546	Belongs to the CinA family
H4J00_RS09180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4J00_RS09185	COG2137	regulation of response to DNA damage stimulus
H4J00_RS09190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4J00_RS09195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H4J00_RS09205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4J00_RS09225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4J00_RS09255	COG2166	iron-sulfur cluster assembly
H4J00_RS09270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4J00_RS09275	COG0137	argininosuccinate synthase activity
H4J00_RS09285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4J00_RS09290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4J00_RS09305	COG0165	Argininosuccinate lyase
H4J00_RS09360	COG4988	ABC transporter
H4J00_RS09365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H4J00_RS09425	COG4133	protoheme IX ABC transporter activity
H4J00_RS09430	COG0436	Aminotransferase
H4J00_RS09450	COG1187	pseudouridine synthase activity
H4J00_RS09455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4J00_RS09460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4J00_RS09465	COG2350	Protein conserved in bacteria
H4J00_RS09495	COG1175	transmembrane transport
H4J00_RS09500	COG0395	ABC-type sugar transport system, permease component
H4J00_RS09525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4J00_RS09535	COG2957	Belongs to the agmatine deiminase family
H4J00_RS09550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4J00_RS09555	COG0539	negative regulation of cytoplasmic translation
H4J00_RS09560	COG0776	regulation of translation
H4J00_RS09570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H4J00_RS09575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4J00_RS09585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4J00_RS09605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4J00_RS09615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4J00_RS09615	COG0519	Catalyzes the synthesis of GMP from XMP
H4J00_RS09620	COG3002	Belongs to the UPF0753 family
H4J00_RS09625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4J00_RS09630	COG0583	DNA-binding transcription factor activity
H4J00_RS09675	COG1914	H( )-stimulated, divalent metal cation uptake system
H4J00_RS09695	COG0668	transmembrane transport
H4J00_RS09720	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS09725	COG1183	phosphatidylcholine synthase activity
H4J00_RS09735	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4J00_RS09750	COG0723	plastoquinol--plastocyanin reductase activity
H4J00_RS09750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_RS09760	COG2183	response to ionizing radiation
H4J00_RS09770	COG0784	Response regulator, receiver
H4J00_RS09770	COG2205	protein histidine kinase activity
H4J00_RS09885	COG3039	Transposase
H4J00_RS09890	COG0800	Aldolase
H4J00_RS09895	COG0129	dihydroxy-acid dehydratase activity
H4J00_RS09900	COG0363	glucosamine-6-phosphate deaminase activity
H4J00_RS09910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4J00_RS09925	COG0354	folic acid binding
H4J00_RS09940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H4J00_RS09955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4J00_RS09970	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4J00_RS09990	COG0811	peptide transport
H4J00_RS10005	COG1663	tetraacyldisaccharide 4'-kinase activity
H4J00_RS10015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4J00_RS10025	COG0322	excinuclease ABC activity
H4J00_RS10050	COG0582	viral genome integration into host DNA
H4J00_RS10060	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS10085	COG3039	Transposase
H4J00_RS10125	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4J00_RS10145	COG1054	Belongs to the UPF0176 family
H4J00_RS10155	COG1530	ribonuclease E activity
H4J00_RS10165	COG3064	Membrane
H4J00_RS10180	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4J00_RS10340	COG0631	protein serine/threonine phosphatase activity
H4J00_RS10345	COG0515	serine threonine protein kinase
H4J00_RS10375	COG1858	cytochrome C peroxidase
H4J00_RS10430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_RS10435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_RS10545	COG2201	protein-glutamate methylesterase activity
H4J00_RS10585	COG4566	intracellular signal transduction
H4J00_RS10595	COG5001	Diguanylate cyclase
H4J00_RS10645	COG1648	precorrin-2 dehydrogenase activity
H4J00_RS10645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4J00_RS10670	COG0746	molybdenum cofactor guanylyltransferase activity
H4J00_RS10700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4J00_RS10715	COG0303	'Molybdopterin
H4J00_RS10720	COG1160	GTP binding
H4J00_RS10725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_RS10745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H4J00_RS10760	COG1024	Enoyl-CoA hydratase
H4J00_RS10760	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4J00_RS10765	COG0183	Belongs to the thiolase family
H4J00_RS10770	COG0038	chloride channel
H4J00_RS10790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4J00_RS10810	COG1674	ftsk spoiiie
H4J00_RS10815	COG0492	ferredoxin-NADP+ reductase activity
H4J00_RS10840	COG0542	response to heat
H4J00_RS10855	COG0482	sulfurtransferase activity
H4J00_RS10885	COG4585	Histidine kinase
H4J00_RS10895	COG4191	Histidine kinase
H4J00_RS10915	COG0835	chemotaxis
H4J00_RS10915	COG0784	Response regulator, receiver
H4J00_RS10925	COG1558	bacterial-type flagellum-dependent cell motility
H4J00_RS10930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H4J00_RS10940	COG4787	bacterial-type flagellum-dependent cell motility
H4J00_RS10960	COG3951	Flagellar rod assembly protein muramidase FlgJ
H4J00_RS10960	COG1705	Flagellar rod assembly protein muramidase FlgJ
H4J00_RS10975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4J00_RS10980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4J00_RS11010	COG2201	protein-glutamate methylesterase activity
H4J00_RS11030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4J00_RS11035	COG4221	oxidoreductase activity
H4J00_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS11075	COG1677	Flagellar hook-basal body complex protein FliE
H4J00_RS11125	COG3190	flagellar
H4J00_RS11140	COG1684	flagellar biosynthetic protein fliR
H4J00_RS11195	COG2198	Histidine kinase
H4J00_RS11195	COG0784	Response regulator, receiver
H4J00_RS11195	COG0643	Histidine kinase
H4J00_RS11280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4J00_RS11285	COG4774	siderophore transport
H4J00_RS11295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H4J00_RS11300	COG1360	Flagellar Motor Protein
H4J00_RS11305	COG1192	Involved in chromosome partitioning
H4J00_RS11310	COG0835	chemotaxis
H4J00_RS11320	COG0745	RESPONSE REGULATOR receiver
H4J00_RS11330	COG0840	transmembrane signaling receptor activity
H4J00_RS11355	COG0840	transmembrane signaling receptor activity
H4J00_RS11360	COG0840	transmembrane signaling receptor activity
H4J00_RS11365	COG0840	transmembrane signaling receptor activity
H4J00_RS11375	COG0840	transmembrane signaling receptor activity
H4J00_RS11380	COG0840	transmembrane signaling receptor activity
H4J00_RS11385	COG0840	transmembrane signaling receptor activity
H4J00_RS11390	COG0840	transmembrane signaling receptor activity
H4J00_RS11395	COG0840	transmembrane signaling receptor activity
H4J00_RS11410	COG0835	chemotaxis
H4J00_RS11420	COG0840	transmembrane signaling receptor activity
H4J00_RS11450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4J00_RS11480	COG0318	PFAM AMP-dependent synthetase and ligase
H4J00_RS11485	COG1024	Enoyl-CoA hydratase
H4J00_RS11490	COG0784	Response regulator, receiver
H4J00_RS11490	COG2198	Histidine kinase
H4J00_RS11490	COG2205	protein histidine kinase activity
H4J00_RS11525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4J00_RS11535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4J00_RS11540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4J00_RS11550	COG0505	Belongs to the CarA family
H4J00_RS11555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4J00_RS11560	COG2258	MOSC domain
H4J00_RS11565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4J00_RS11610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4J00_RS11630	COG0277	FAD linked oxidase domain protein
H4J00_RS11635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4J00_RS11645	COG0531	amino acid
H4J00_RS11650	COG0531	amino acid
H4J00_RS11655	COG0235	Class ii aldolase
H4J00_RS11660	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H4J00_RS11680	COG0140	phosphoribosyl-ATP diphosphatase activity
H4J00_RS11680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4J00_RS11690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4J00_RS11700	COG0131	Imidazoleglycerol-phosphate dehydratase
H4J00_RS11700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4J00_RS11715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4J00_RS11730	COG0124	histidyl-tRNA synthetase
H4J00_RS11740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4J00_RS11750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4J00_RS11765	COG2801	Transposase and inactivated derivatives
H4J00_RS11805	COG1012	belongs to the aldehyde dehydrogenase family
H4J00_RS11830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4J00_RS11835	COG0697	spore germination
H4J00_RS11855	COG0671	phosphoesterase, PA-phosphatase related
H4J00_RS11870	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H4J00_RS11875	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_RS11885	COG4251	negative regulation of phosphorylation
H4J00_RS11885	COG3706	GGDEF domain
H4J00_RS11885	COG2203	Gaf domain
H4J00_RS11885	COG5001	Diguanylate cyclase
H4J00_RS11900	COG1472	Belongs to the glycosyl hydrolase 3 family
H4J00_RS11925	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4J00_RS11945	COG0617	tRNA 3'-terminal CCA addition
H4J00_RS11955	COG1469	GTP cyclohydrolase I activity
H4J00_RS11960	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4J00_RS11970	COG0477	Major facilitator Superfamily
H4J00_RS11980	COG1070	Carbohydrate kinase
H4J00_RS12005	COG0800	Aldolase
H4J00_RS12010	COG4948	Mandelate Racemase Muconate Lactonizing
H4J00_RS12020	COG3734	2-keto-3-deoxy-galactonokinase
H4J00_RS12025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4J00_RS12035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4J00_RS12050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4J00_RS12055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4J00_RS12065	COG0351	phosphomethylpyrimidine kinase
H4J00_RS12065	COG0352	thiamine-phosphate diphosphorylase activity
H4J00_RS12090	COG0583	DNA-binding transcription factor activity
H4J00_RS12095	COG1741	Belongs to the pirin family
H4J00_RS12140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4J00_RS12145	COG0402	S-adenosylhomocysteine deaminase activity
H4J00_RS12160	COG1509	lysine 2,3-aminomutase activity
H4J00_RS12165	COG5001	Diguanylate cyclase
H4J00_RS12165	COG3300	MHYT domain
H4J00_RS12180	COG0483	inositol monophosphate 1-phosphatase activity
H4J00_RS12185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4J00_RS12210	COG0488	(ABC) transporter
H4J00_RS12215	COG0513	Belongs to the DEAD box helicase family
H4J00_RS12225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4J00_RS12235	COG0625	glutathione transferase activity
H4J00_RS12245	COG1671	Belongs to the UPF0178 family
H4J00_RS12250	COG4681	YaeQ
H4J00_RS12255	COG2081	HI0933 family
H4J00_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS12295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4J00_RS12300	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4J00_RS12305	COG0802	atpase or kinase
H4J00_RS12310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4J00_RS12310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4J00_RS12315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4J00_RS12335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4J00_RS12400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4J00_RS12495	COG2801	Transposase and inactivated derivatives
H4J00_RS12510	COG0835	chemotaxis
H4J00_RS12515	COG0840	transmembrane signaling receptor activity
H4J00_RS12540	COG2969	positive regulation of protein catabolic process
H4J00_RS12545	COG0625	glutathione transferase activity
H4J00_RS12550	COG2857	Cytochrome c1
H4J00_RS12555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4J00_RS12560	COG0723	plastoquinol--plastocyanin reductase activity
H4J00_RS12565	COG0741	lytic transglycosylase activity
H4J00_RS12590	COG1702	phosphate starvation-inducible protein PhoH
H4J00_RS12610	COG4535	Mg2 and Co2 transporter CorC
H4J00_RS12625	COG1012	belongs to the aldehyde dehydrogenase family
H4J00_RS12630	COG1177	transmembrane transport
H4J00_RS12635	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4J00_RS12645	COG3842	ATPase activity
H4J00_RS12665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4J00_RS12690	COG2201	protein-glutamate methylesterase activity
H4J00_RS12700	COG2201	protein-glutamate methylesterase activity
H4J00_RS12765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4J00_RS12770	COG0174	glutamine synthetase
H4J00_RS12775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_RS12785	COG0477	Major facilitator Superfamily
H4J00_RS12795	COG0243	molybdopterin cofactor binding
H4J00_RS12815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4J00_RS12820	COG1121	(ABC) transporter
H4J00_RS12830	COG2733	membrane
H4J00_RS12835	COG2205	protein histidine kinase activity
H4J00_RS12835	COG5002	protein histidine kinase activity
H4J00_RS12835	COG0784	Response regulator, receiver
H4J00_RS12850	COG0477	Major facilitator Superfamily
H4J00_RS12860	COG2902	Dehydrogenase
H4J00_RS12870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_RS12875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_RS12885	COG1609	Transcriptional regulator
H4J00_RS12890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4J00_RS12890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4J00_RS12895	COG1105	Belongs to the carbohydrate kinase PfkB family
H4J00_RS12900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4J00_RS12900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4J00_RS12910	COG3039	Transposase
H4J00_RS12950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4J00_RS12960	COG1862	Preprotein translocase
H4J00_RS12965	COG0343	queuine tRNA-ribosyltransferase activity
H4J00_RS13020	COG0405	Gamma-glutamyltransferase
H4J00_RS13025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4J00_RS13035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4J00_RS13040	COG0742	ribosomal rna small subunit methyltransferase
H4J00_RS13045	COG0326	Molecular chaperone. Has ATPase activity
H4J00_RS13085	COG4206	TonB-dependent receptor
H4J00_RS13115	COG0531	amino acid
H4J00_RS13130	COG0006	proline dipeptidase activity
H4J00_RS13140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4J00_RS13155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_RS13160	COG3938	Belongs to the proline racemase family
H4J00_RS13170	COG0552	protein localization to endoplasmic reticulum
H4J00_RS13180	COG1194	a g-specific adenine glycosylase
H4J00_RS13190	COG0784	Response regulator, receiver
H4J00_RS13190	COG4191	Histidine kinase
H4J00_RS13195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4J00_RS13215	COG3040	lipid binding
H4J00_RS13225	COG1960	acyl-CoA dehydrogenase activity
H4J00_RS13235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4J00_RS13265	COG0438	transferase activity, transferring glycosyl groups
H4J00_RS13275	COG0438	transferase activity, transferring glycosyl groups
H4J00_RS13280	COG0438	transferase activity, transferring glycosyl groups
H4J00_RS13335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4J00_RS13350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4J00_RS13375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H4J00_RS13390	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H4J00_RS13410	COG3115	cell septum assembly
H4J00_RS13430	COG0360	Binds together with S18 to 16S ribosomal RNA
H4J00_RS13435	COG0316	Belongs to the HesB IscA family
H4J00_RS13465	COG0288	reversible hydration of carbon dioxide
H4J00_RS13480	COG3844	kynureninase activity
H4J00_RS13490	COG2925	Exonuclease
H4J00_RS13500	COG0667	Aldo Keto reductase
H4J00_RS13525	COG0116	Belongs to the methyltransferase superfamily
H4J00_RS13525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4J00_RS13570	COG0494	nUDIX hydrolase
H4J00_RS13585	COG1024	Enoyl-CoA hydratase
H4J00_RS13595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4J00_RS13625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4J00_RS13630	COG0573	inorganic phosphate transmembrane transporter activity
H4J00_RS13645	COG0704	Plays a role in the regulation of phosphate uptake
H4J00_RS13655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4J00_RS13665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4J00_RS13680	COG0557	exoribonuclease II activity
H4J00_RS13705	COG1960	acyl-CoA dehydrogenase activity
H4J00_RS13710	COG2226	methyltransferase
H4J00_RS13730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_RS13740	COG1609	Transcriptional regulator
H4J00_RS13755	COG2900	Belongs to the SlyX family
H4J00_RS13770	COG0386	Belongs to the glutathione peroxidase family
H4J00_RS13780	COG1725	Transcriptional regulator
H4J00_RS13785	COG1131	(ABC) transporter
H4J00_RS13820	COG4535	Mg2 and Co2 transporter CorC
H4J00_RS13850	COG2850	peptidyl-arginine hydroxylation
H4J00_RS13890	COG1132	(ABC) transporter
H4J00_RS13900	COG0583	DNA-binding transcription factor activity
H4J00_RS13925	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H4J00_RS13930	COG0484	heat shock protein binding
H4J00_RS13935	COG0443	Heat shock 70 kDa protein
H4J00_RS13940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4J00_RS13950	COG0497	DNA recombination
H4J00_RS13960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_RS13965	COG2914	Belongs to the UPF0125 (RnfH) family
H4J00_RS13975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4J00_RS14065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_RS14070	COG2311	Membrane
H4J00_RS14075	COG1047	Peptidyl-prolyl cis-trans
H4J00_RS14080	COG0791	NLP P60 protein
H4J00_RS14085	COG0791	NLP P60 protein
H4J00_RS14100	COG4106	trans-aconitate 2-methyltransferase activity
H4J00_RS14105	COG1301	dicarboxylic acid transport
H4J00_RS14110	COG1785	Belongs to the alkaline phosphatase family
H4J00_RS14115	COG0037	tRNA processing
H4J00_RS14120	COG1722	exodeoxyribonuclease VII activity
H4J00_RS14125	COG0142	geranyltranstransferase activity
H4J00_RS14130	COG4104	PAAR repeat-containing protein
H4J00_RS14150	COG0312	modulator of DNA gyrase
H4J00_RS14155	COG3028	Belongs to the UPF0307 family
H4J00_RS14160	COG0312	modulator of DNA gyrase
H4J00_RS14170	COG3164	Protein of unknown function
H4J00_RS14185	COG2968	Membrane
H4J00_RS14210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H4J00_RS14230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4J00_RS14255	COG3118	belongs to the thioredoxin family
H4J00_RS14315	COG1132	(ABC) transporter
H4J00_RS14345	COG0745	RESPONSE REGULATOR receiver
H4J00_RS14350	COG5000	phosphorelay sensor kinase activity
H4J00_RS14350	COG5002	protein histidine kinase activity
H4J00_RS14355	COG0475	glutathione-regulated potassium exporter activity
H4J00_RS14365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4J00_RS14385	COG1187	pseudouridine synthase activity
H4J00_RS14390	COG5001	Diguanylate cyclase
H4J00_RS14390	COG5002	protein histidine kinase activity
H4J00_RS14440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4J00_RS14515	COG0735	belongs to the Fur family
H4J00_RS14520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4J00_RS14560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4J00_RS14570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4J00_RS14585	COG0643	Histidine kinase
H4J00_RS14585	COG2198	Histidine kinase
H4J00_RS14590	COG0840	transmembrane signaling receptor activity
H4J00_RS14595	COG0835	chemotaxis
H4J00_RS14600	COG2199	diguanylate cyclase activity
H4J00_RS14600	COG2200	EAL domain
H4J00_RS14600	COG2202	Pas domain
H4J00_RS14605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4J00_RS14620	COG3409	Peptidoglycan-binding domain 1 protein
H4J00_RS14620	COG3501	Rhs element vgr protein
H4J00_RS14665	COG3501	Rhs element vgr protein
H4J00_RS14665	COG3409	Peptidoglycan-binding domain 1 protein
H4J00_RS14685	COG1515	deoxyribonuclease V activity
H4J00_RS14695	COG1741	Belongs to the pirin family
H4J00_RS14795	COG1741	Belongs to the pirin family
H4J00_RS14800	COG1966	Carbon starvation protein
H4J00_RS14805	COG2879	small protein
H4J00_RS14860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H4J00_RS14865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4J00_RS14870	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H4J00_RS14875	COG2080	2 iron, 2 sulfur cluster binding
H4J00_RS14885	COG5001	Diguanylate cyclase
H4J00_RS14885	COG4251	negative regulation of phosphorylation
H4J00_RS14885	COG3706	GGDEF domain
H4J00_RS14885	COG2203	Gaf domain
H4J00_RS14890	COG0629	single-stranded DNA binding
H4J00_RS14895	COG0142	geranyltranstransferase activity
H4J00_RS14920	COG0527	aspartate kinase activity
H4J00_RS14930	COG0384	phenazine biosynthesis protein PhzF
H4J00_RS14940	COG1764	response to oxidative stress
H4J00_RS14955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4J00_RS14960	COG1678	Uncharacterized ACR, COG1678
H4J00_RS14975	COG0519	Catalyzes the synthesis of GMP from XMP
H4J00_RS15005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4J00_RS15060	COG1959	2 iron, 2 sulfur cluster binding
H4J00_RS15065	COG0719	Fe-S assembly protein
H4J00_RS15070	COG0396	ATPase activity
H4J00_RS15075	COG0719	Fe-S assembly protein
H4J00_RS15080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4J00_RS15090	COG2146	nitrite reductase [NAD(P)H] activity
H4J00_RS15105	COG1555	photosystem II stabilization
H4J00_RS15110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4J00_RS15125	COG3178	'Phosphotransferase
H4J00_RS15130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4J00_RS15140	COG0628	permease
H4J00_RS15150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4J00_RS15165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4J00_RS15185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4J00_RS15190	COG0271	Belongs to the BolA IbaG family
H4J00_RS15200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4J00_RS15210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H4J00_RS15215	COG1137	ATPase activity
H4J00_RS15230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4J00_RS15240	COG1660	Displays ATPase and GTPase activities
H4J00_RS15250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4J00_RS15255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4J00_RS15260	COG2239	Acts as a magnesium transporter
H4J00_RS15270	COG1294	oxidase, subunit
H4J00_RS15275	COG1271	oxidase subunit
H4J00_RS15285	COG1113	amino acid transport
H4J00_RS15300	COG2197	response regulator
H4J00_RS15305	COG0531	amino acid
H4J00_RS15365	COG0754	glutathionylspermidine amidase activity
H4J00_RS15390	COG1842	Phage shock protein A
H4J00_RS15405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4J00_RS15480	COG2801	Transposase and inactivated derivatives
H4J00_RS15495	COG3409	Peptidoglycan-binding domain 1 protein
H4J00_RS15495	COG3501	Rhs element vgr protein
H4J00_RS15500	COG3039	Transposase
H4J00_RS15835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H4J00_RS15860	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4J00_RS15875	COG2197	response regulator
H4J00_RS15880	COG4585	Histidine kinase
H4J00_RS15895	COG2894	cell division
H4J00_RS15900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H4J00_RS15910	COG0642	Histidine kinase
H4J00_RS15915	COG0745	RESPONSE REGULATOR receiver
H4J00_RS15920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H4J00_RS15930	COG2194	sulfuric ester hydrolase activity
H4J00_RS15960	COG3551	Protein conserved in bacteria
H4J00_RS15995	COG0753	catalase activity
H4J00_RS16030	COG2207	Transcriptional regulator
H4J00_RS16030	COG1917	Cupin 2, conserved barrel domain protein
H4J00_RS16040	COG1506	peptidase
H4J00_RS16040	COG0823	Involved in the tonB-independent uptake of proteins
H4J00_RS16055	COG1297	OPT oligopeptide transporter protein
H4J00_RS16070	COG0587	DNA-directed DNA polymerase activity
H4J00_RS16150	COG3039	Transposase
H4J00_RS16155	COG0732	type I restriction modification DNA specificity domain
H4J00_RS16190	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H4J00_RS16235	COG0308	aminopeptidase N
H4J00_RS16250	COG0330	HflC and HflK could
H4J00_RS16255	COG0330	HflC and HflK could
H4J00_RS16275	COG0678	peroxiredoxin activity
H4J00_RS16335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4J00_RS16350	COG3829	transcription factor binding
H4J00_RS16360	COG3039	Transposase
H4J00_RS16385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4J00_RS16390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4J00_RS16400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4J00_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS16430	COG1399	metal-binding, possibly nucleic acid-binding protein
H4J00_RS16450	COG0714	Associated with various cellular activities
H4J00_RS16470	COG0537	adenosine 5'-monophosphoramidase activity
H4J00_RS16480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H4J00_RS16500	COG0314	molybdopterin synthase activity
H4J00_RS16505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4J00_RS16510	COG0315	cyclic pyranopterin monophosphate synthase activity
H4J00_RS16520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4J00_RS16525	COG1234	tRNA 3'-trailer cleavage
H4J00_RS16530	COG3642	lipopolysaccharide core region biosynthetic process
H4J00_RS16535	COG0859	PFAM glycosyl transferase family 9
H4J00_RS16550	COG0631	protein serine/threonine phosphatase activity
H4J00_RS16555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4J00_RS16580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4J00_RS16620	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4J00_RS16665	COG0473	3-isopropylmalate dehydrogenase activity
H4J00_RS16680	COG4783	chaperone-mediated protein folding
H4J00_RS16695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4J00_RS16705	COG0438	transferase activity, transferring glycosyl groups
H4J00_RS16710	COG0671	phosphoesterase, PA-phosphatase related
H4J00_RS16715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4J00_RS16735	COG2833	Protein of unknown function (DUF455)
H4J00_RS16755	COG0285	dihydrofolate synthase activity
H4J00_RS16760	COG0406	alpha-ribazole phosphatase activity
H4J00_RS16795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4J00_RS16800	COG4208	sulfate ABC transporter
H4J00_RS16805	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4J00_RS16810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4J00_RS16815	COG0156	8-amino-7-oxononanoate synthase activity
H4J00_RS16840	COG0604	alcohol dehydrogenase
H4J00_RS16845	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4J00_RS16845	COG1902	pentaerythritol trinitrate reductase activity
H4J00_RS16880	COG0584	glycerophosphoryl diester phosphodiesterase
H4J00_RS16905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4J00_RS16910	COG1217	gtp-binding protein TYPA
H4J00_RS16930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H4J00_RS16945	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4J00_RS16950	COG0203	ribosomal protein L17
H4J00_RS16960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4J00_RS16965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4J00_RS16975	COG0201	protein transport
H4J00_RS16980	COG0200	Binds to the 23S rRNA
H4J00_RS16985	COG1841	ribosomal large subunit assembly
H4J00_RS17015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4J00_RS17020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4J00_RS17025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H4J00_RS17030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4J00_RS17035	COG0255	Belongs to the universal ribosomal protein uL29 family
H4J00_RS17040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4J00_RS17050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4J00_RS17060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4J00_RS17065	COG0089	rRNA binding
H4J00_RS17070	COG0088	Forms part of the polypeptide exit tunnel
H4J00_RS17080	COG0051	transcription antitermination factor activity, RNA binding
H4J00_RS17100	COG0049	tRNA binding
H4J00_RS17105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4J00_RS17110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4J00_RS17115	COG0085	RNA polymerase activity
H4J00_RS17125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4J00_RS17130	COG0081	regulation of translation
H4J00_RS17135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4J00_RS17140	COG0250	Participates in transcription elongation, termination and antitermination
H4J00_RS17145	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4J00_RS17175	COG0012	GTP binding
H4J00_RS17180	COG0193	aminoacyl-tRNA hydrolase activity
H4J00_RS17190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4J00_RS17205	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H4J00_RS17215	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H4J00_RS17220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4J00_RS17230	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4J00_RS17250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4J00_RS17255	COG1295	ribonuclease BN
H4J00_RS17290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4J00_RS17300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4J00_RS17355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H4J00_RS17400	COG2890	protein-(glutamine-N5) methyltransferase activity
H4J00_RS17410	COG3634	alkyl hydroperoxide reductase activity
H4J00_RS17415	COG0583	DNA-binding transcription factor activity
H4J00_RS17425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4J00_RS17430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4J00_RS17440	COG2197	response regulator
H4J00_RS17470	COG0697	spore germination
H4J00_RS17500	COG3386	PFAM SMP-30 Gluconolaconase
H4J00_RS17520	COG1024	Enoyl-CoA hydratase
H4J00_RS17530	COG0318	PFAM AMP-dependent synthetase and ligase
H4J00_RS17535	COG0583	DNA-binding transcription factor activity
H4J00_RS17540	COG3384	dioxygenase
H4J00_RS17570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4J00_RS17575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4J00_RS17585	COG2096	Adenosyltransferase
H4J00_RS17590	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4J00_RS17605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4J00_RS17615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4J00_RS17620	COG2967	ApaG domain
H4J00_RS17625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4J00_RS17645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4J00_RS17665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4J00_RS17680	COG0642	Histidine kinase
H4J00_RS17695	COG4181	ATPase activity
H4J00_RS17705	COG2175	clavaminate synthase activity
H4J00_RS17740	COG0667	Aldo Keto reductase
H4J00_RS17750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4J00_RS17755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_RS17765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4J00_RS17780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4J00_RS17820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4J00_RS17825	COG2226	methyltransferase
H4J00_RS17870	COG0604	alcohol dehydrogenase
H4J00_RS17870	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS17870	COG3321	synthase
H4J00_RS17880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4J00_RS17895	COG0494	nUDIX hydrolase
H4J00_RS17910	COG1388	LysM domain
H4J00_RS17910	COG4942	peptidase
H4J00_RS17920	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H4J00_RS17940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4J00_RS17945	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4J00_RS17950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4J00_RS17965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4J00_RS17970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4J00_RS17985	COG3116	cell division
H4J00_RS17990	COG0275	rRNA processing
H4J00_RS18030	COG0792	nuclease activity
H4J00_RS18035	COG1988	membrane-bound metal-dependent
H4J00_RS18040	COG0277	FAD linked oxidase domain protein
H4J00_RS18045	COG0745	RESPONSE REGULATOR receiver
H4J00_RS18050	COG2205	protein histidine kinase activity
H4J00_RS18060	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4J00_RS18065	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4J00_RS18085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H4J00_RS18090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4J00_RS18095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4J00_RS18115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4J00_RS18115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4J00_RS18130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4J00_RS18140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4J00_RS18160	COG0488	(ABC) transporter
H4J00_RS18180	COG3791	Glutathione-dependent formaldehyde-activating
H4J00_RS18205	COG2205	protein histidine kinase activity
H4J00_RS18245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4J00_RS18280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H4J00_RS18305	COG1649	PFAM Uncharacterised BCR, COG1649
H4J00_RS18305	COG0726	polysaccharide deacetylase
H4J00_RS18310	COG1215	transferase activity, transferring glycosyl groups
H4J00_RS18320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4J00_RS18325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4J00_RS18330	COG1609	Transcriptional regulator
H4J00_RS18340	COG2188	Transcriptional regulator
H4J00_RS18355	COG3250	beta-galactosidase activity
H4J00_RS18390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4J00_RS18395	COG4191	Histidine kinase
H4J00_RS18400	COG0784	Response regulator, receiver
H4J00_RS18405	COG4251	negative regulation of phosphorylation
H4J00_RS18410	COG2823	Periplasmic or secreted lipoprotein
H4J00_RS18415	COG0673	inositol 2-dehydrogenase activity
H4J00_RS18420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H4J00_RS18455	COG1056	cytidyltransferase-related domain
H4J00_RS18455	COG1051	belongs to the nudix hydrolase family
H4J00_RS18480	COG2921	Belongs to the UPF0250 family
H4J00_RS18495	COG1686	Belongs to the peptidase S11 family
H4J00_RS18500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4J00_RS18505	COG2951	lytic endotransglycosylase activity
H4J00_RS18545	COG1388	LysM domain
H4J00_RS18545	COG3409	Peptidoglycan-binding domain 1 protein
H4J00_RS18545	COG5632	N-Acetylmuramoyl-L-alanine amidase
H4J00_RS18560	COG0772	Belongs to the SEDS family
H4J00_RS18575	COG1792	Involved in formation and maintenance of cell shape
H4J00_RS18580	COG1077	Cell shape determining protein MreB Mrl
H4J00_RS18585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_RS18605	COG5001	Diguanylate cyclase
H4J00_RS18605	COG3300	MHYT domain
H4J00_RS18650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4J00_RS18670	COG2832	Protein of unknown function (DUF454)
H4J00_RS18680	COG0436	Aminotransferase
H4J00_RS18690	COG1505	serine-type exopeptidase activity
H4J00_RS18715	COG0181	hydroxymethylbilane synthase activity
H4J00_RS18725	COG3275	phosphorelay sensor kinase activity
H4J00_RS18740	COG3039	Transposase
H4J00_RS18760	COG0659	secondary active sulfate transmembrane transporter activity
H4J00_RS18840	COG0598	Magnesium transport protein CorA
H4J00_RS18850	COG1113	amino acid transport
H4J00_RS18870	COG4305	rare lipoprotein A
H4J00_RS18875	COG0697	spore germination
H4J00_RS18935	COG4221	oxidoreductase activity
H4J00_RS18975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4J00_RS19000	COG0459	protein refolding
H4J00_RS19030	COG2860	membrane
H4J00_RS19035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4J00_RS19040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4J00_RS19045	COG2201	protein-glutamate methylesterase activity
H4J00_RS19050	COG2177	Part of the ABC transporter FtsEX involved in
H4J00_RS19055	COG2884	Cell division ATP-binding protein ftsE
H4J00_RS19065	COG3118	belongs to the thioredoxin family
H4J00_RS19070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4J00_RS19105	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4J00_RS19105	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4J00_RS19115	COG1473	amidohydrolase
H4J00_RS19120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_RS19125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_RS19150	COG5383	Protein conserved in bacteria
H4J00_RS19190	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H4J00_RS19195	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4J00_RS19205	COG4948	Mandelate Racemase Muconate Lactonizing
H4J00_RS19220	COG0531	amino acid
H4J00_RS19240	COG4682	membrane
H4J00_RS19250	COG2133	pyrroloquinoline quinone binding
H4J00_RS19270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4J00_RS19275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4J00_RS19290	COG1610	YqeY-like protein
H4J00_RS19305	COG1295	ribonuclease BN
H4J00_RS19310	COG0358	DNA primase activity
H4J00_RS19365	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H4J00_RS19380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4J00_RS19435	COG0739	heme binding
H4J00_RS19450	COG2211	Major facilitator Superfamily
H4J00_RS19455	COG0708	Exodeoxyribonuclease III
H4J00_RS19505	COG2111	Na H antiporter
H4J00_RS19505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4J00_RS19510	COG1006	Multisubunit Na H antiporter MnhC subunit
H4J00_RS19515	COG0651	ATP synthesis coupled electron transport
H4J00_RS19525	COG2212	antiporter activity
H4J00_RS19530	COG1320	monovalent cation:proton antiporter activity
H4J00_RS19540	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H4J00_RS19565	COG3104	oligopeptide transport
H4J00_RS19570	COG3483	tryptophan 2,3-dioxygenase activity
H4J00_RS19580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4J00_RS19595	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4J00_RS19610	COG3039	Transposase
H4J00_RS19615	COG0513	Belongs to the DEAD box helicase family
H4J00_RS19665	COG2801	Transposase and inactivated derivatives
H4J00_RS19685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4J00_RS19690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4J00_RS19700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4J00_RS19700	COG1042	CoA-binding domain protein
H4J00_RS19700	COG0045	succinate-CoA ligase (ADP-forming) activity
H4J00_RS19710	COG2239	Acts as a magnesium transporter
H4J00_RS19730	COG3039	Transposase
H4J00_RS19745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4J00_RS19750	COG3387	PFAM Glycoside hydrolase 15-related
H4J00_RS19765	COG3100	YcgL domain-containing protein
H4J00_RS19770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4J00_RS19780	COG0463	Glycosyl transferase, family 2
H4J00_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS19855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4J00_RS19900	COG0408	coproporphyrinogen oxidase activity
H4J00_RS19975	COG0210	DNA helicase
H4J00_RS19990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4J00_RS19995	COG0583	DNA-binding transcription factor activity
H4J00_RS20000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4J00_RS20010	COG2159	amidohydrolase
H4J00_RS20035	COG0357	Ribosomal RNA small subunit methyltransferase G
H4J00_RS20040	COG3540	Alkaline phosphatase
H4J00_RS20050	COG2091	lysine biosynthetic process via aminoadipic acid
H4J00_RS20065	COG0708	Exodeoxyribonuclease III
H4J00_RS20080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4J00_RS20085	COG3162	membrane
H4J00_RS20125	COG1414	Transcriptional regulator
H4J00_RS20135	COG2205	protein histidine kinase activity
H4J00_RS20145	COG3459	Glycosyltransferase 36 associated
H4J00_RS20155	COG3265	gluconokinase activity
H4J00_RS20160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_RS20165	COG3039	Transposase
H4J00_RS20180	COG0339	signal peptide processing
H4J00_RS20210	COG0564	pseudouridine synthase activity
H4J00_RS20225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4J00_RS20235	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4J00_RS20240	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS20250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4J00_RS20255	COG0318	PFAM AMP-dependent synthetase and ligase
H4J00_RS20260	COG0727	PFAM Uncharacterised protein family (UPF0153)
H4J00_RS20265	COG0596	Alpha beta hydrolase
H4J00_RS20270	COG3177	Filamentation induced by cAMP protein fic
H4J00_RS20275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4J00_RS20290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4J00_RS20315	COG4191	Histidine kinase
H4J00_RS20320	COG0028	Belongs to the TPP enzyme family
H4J00_RS20335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H4J00_RS20340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4J00_RS20385	COG3039	Transposase
H4J00_RS20395	COG0183	Belongs to the thiolase family
H4J00_RS20420	COG3039	Transposase
H4J00_RS20425	COG3039	Transposase
H4J00_RS20450	COG2032	superoxide dismutase activity
H4J00_RS20455	COG2032	superoxide dismutase activity
H4J00_RS20460	COG2204	response regulator
H4J00_RS20465	COG3852	Histidine kinase
H4J00_RS20470	COG0004	ammonium transporteR
H4J00_RS20475	COG0347	Belongs to the P(II) protein family
H4J00_RS20480	COG0174	glutamine synthetase
H4J00_RS20485	COG1968	undecaprenyl-diphosphatase activity
H4J00_RS20530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4J00_RS20540	COG2062	phosphohistidine phosphatase, SixA
H4J00_RS20545	COG0489	protein tyrosine kinase activity
H4J00_RS20565	COG1396	sequence-specific DNA binding
H4J00_RS20570	COG3550	peptidyl-serine autophosphorylation
H4J00_RS20575	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H4J00_RS20580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4J00_RS20595	COG1125	glycine betaine transport
H4J00_RS20595	COG0517	IMP dehydrogenase activity
H4J00_RS20610	COG1119	ATPase activity
H4J00_RS20620	COG1473	amidohydrolase
H4J00_RS20625	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4J00_RS20635	COG1522	sequence-specific DNA binding
H4J00_RS20640	COG3186	Phenylalanine-4-hydroxylase
H4J00_RS20655	COG2755	lipolytic protein G-D-S-L family
H4J00_RS20665	COG1609	Transcriptional regulator
H4J00_RS20690	COG0366	Alpha amylase catalytic
H4J00_RS20695	COG0366	Alpha amylase catalytic
H4J00_RS20705	COG2831	hemolysin activation secretion protein
H4J00_RS20710	COG3210	domain, Protein
H4J00_RS20720	COG3210	domain, Protein
H4J00_RS20760	COG3135	benzoate transporter
H4J00_RS20780	COG0676	glucose-6-phosphate 1-epimerase activity
H4J00_RS20835	COG0302	gtp cyclohydrolase
H4J00_RS20865	COG0477	Major facilitator Superfamily
H4J00_RS20935	COG3237	CsbD-like
H4J00_RS21025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_RS21055	COG1755	Isoprenylcysteine carboxyl methyltransferase
H4J00_RS21060	COG1304	FMN binding
H4J00_RS21065	COG3039	Transposase
H4J00_RS21075	COG4772	TonB-dependent receptor
H4J00_RS21085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4J00_RS21110	COG1272	protein, Hemolysin III
H4J00_RS21115	COG1205	dead DEAH box helicase
H4J00_RS21115	COG1111	helicase
H4J00_RS21175	COG0069	glutamate synthase activity
H4J00_RS21175	COG0070	glutamate synthase
H4J00_RS21175	COG0067	glutamate synthase
H4J00_RS21180	COG0493	'glutamate synthase
H4J00_RS21190	COG0531	amino acid
H4J00_RS21200	COG1322	Protein conserved in bacteria
H4J00_RS21210	COG0386	Belongs to the glutathione peroxidase family
H4J00_RS21215	COG2853	Lipoprotein
H4J00_RS21230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4J00_RS21235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4J00_RS21240	COG1127	ABC transporter
H4J00_RS21275	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H4J00_RS21280	COG1074	ATP-dependent DNA helicase activity
H4J00_RS21285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4J00_RS21345	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_RS21365	COG3039	Transposase
H4J00_RS21375	COG2124	cytochrome p450
H4J00_RS21380	COG2124	cytochrome p450
H4J00_RS21385	COG1141	Ferredoxin
H4J00_RS21390	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_RS21395	COG2124	cytochrome p450
H4J00_RS21400	COG0142	geranyltranstransferase activity
H4J00_RS21405	COG1657	PFAM Prenyltransferase squalene oxidase
H4J00_RS21415	COG1304	FMN binding
H4J00_RS21430	COG0564	pseudouridine synthase activity
H4J00_RS21455	COG3706	GGDEF domain
H4J00_RS21465	COG1929	Belongs to the glycerate kinase type-1 family
H4J00_RS21470	COG2271	Major facilitator Superfamily
H4J00_RS21490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4J00_RS21495	COG0861	Integral membrane protein TerC family
H4J00_RS21505	COG0584	glycerophosphoryl diester phosphodiesterase
H4J00_RS21515	COG0671	phosphoesterase, PA-phosphatase related
H4J00_RS21520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4J00_RS21525	COG0726	polysaccharide deacetylase