locus-tag	class	description
XPE_RS00035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XPE_RS00040	COG0343	queuine tRNA-ribosyltransferase activity
XPE_RS00045	COG1862	Preprotein translocase
XPE_RS00055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XPE_RS00100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XPE_RS00100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XPE_RS00105	COG1105	Belongs to the carbohydrate kinase PfkB family
XPE_RS00110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XPE_RS00110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPE_RS00115	COG1609	Transcriptional regulator
XPE_RS00120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_RS00125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_RS00135	COG2902	Dehydrogenase
XPE_RS00140	COG0477	Major facilitator Superfamily
XPE_RS00150	COG5002	protein histidine kinase activity
XPE_RS00150	COG2205	protein histidine kinase activity
XPE_RS00150	COG0784	Response regulator, receiver
XPE_RS00155	COG2733	membrane
XPE_RS00165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XPE_RS00175	COG2223	nitrite transmembrane transporter activity
XPE_RS00180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XPE_RS00185	COG0243	molybdopterin cofactor binding
XPE_RS00195	COG0477	Major facilitator Superfamily
XPE_RS00200	COG2703	oxygen carrier activity
XPE_RS00210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_RS00215	COG0174	glutamine synthetase
XPE_RS00220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XPE_RS00235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XPE_RS00255	COG3842	ATPase activity
XPE_RS00265	COG1176	ABC-type spermidine putrescine transport system, permease component I
XPE_RS00270	COG1177	transmembrane transport
XPE_RS00275	COG1012	belongs to the aldehyde dehydrogenase family
XPE_RS00290	COG4535	Mg2 and Co2 transporter CorC
XPE_RS00300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XPE_RS00310	COG1702	phosphate starvation-inducible protein PhoH
XPE_RS00315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XPE_RS00330	COG0741	lytic transglycosylase activity
XPE_RS00340	COG0723	plastoquinol--plastocyanin reductase activity
XPE_RS00345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XPE_RS00350	COG2857	Cytochrome c1
XPE_RS00355	COG0625	glutathione transferase activity
XPE_RS00360	COG2969	positive regulation of protein catabolic process
XPE_RS00380	COG1201	RNA secondary structure unwinding
XPE_RS00385	COG2094	Belongs to the DNA glycosylase MPG family
XPE_RS00390	COG0840	transmembrane signaling receptor activity
XPE_RS00395	COG0835	chemotaxis
XPE_RS00445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XPE_RS00460	COG1570	exodeoxyribonuclease VII activity
XPE_RS00465	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPE_RS00470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XPE_RS00470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XPE_RS00475	COG0802	atpase or kinase
XPE_RS00480	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPE_RS00485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XPE_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS00515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPE_RS00520	COG0501	Belongs to the peptidase M48B family
XPE_RS00530	COG2081	HI0933 family
XPE_RS00535	COG4681	YaeQ
XPE_RS00545	COG0625	glutathione transferase activity
XPE_RS00555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XPE_RS00560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XPE_RS00565	COG0513	Belongs to the DEAD box helicase family
XPE_RS00570	COG0488	(ABC) transporter
XPE_RS00585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XPE_RS00590	COG0483	inositol monophosphate 1-phosphatase activity
XPE_RS00605	COG5001	Diguanylate cyclase
XPE_RS00605	COG3300	MHYT domain
XPE_RS00610	COG1509	lysine 2,3-aminomutase activity
XPE_RS00615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPE_RS00625	COG0402	S-adenosylhomocysteine deaminase activity
XPE_RS00630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XPE_RS00645	COG4677	pectinesterase activity
XPE_RS00670	COG4302	ethanolamine ammonia-lyase activity
XPE_RS00700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XPE_RS00705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XPE_RS00720	COG2166	iron-sulfur cluster assembly
XPE_RS00725	COG0215	cysteine-tRNA ligase activity
XPE_RS00735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XPE_RS00740	COG0137	argininosuccinate synthase activity
XPE_RS00750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XPE_RS00755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XPE_RS00765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XPE_RS00770	COG0165	Argininosuccinate lyase
XPE_RS00780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XPE_RS00785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XPE_RS00815	COG1294	oxidase, subunit
XPE_RS00825	COG4988	ABC transporter
XPE_RS00830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XPE_RS00835	COG1278	Cold shock
XPE_RS00840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_RS00860	COG1138	Cytochrome C-type biogenesis protein
XPE_RS00865	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XPE_RS00885	COG4133	protoheme IX ABC transporter activity
XPE_RS00890	COG0436	Aminotransferase
XPE_RS00910	COG1187	pseudouridine synthase activity
XPE_RS00915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XPE_RS00920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XPE_RS00925	COG2350	Protein conserved in bacteria
XPE_RS00960	COG0395	ABC-type sugar transport system, permease component
XPE_RS00985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPE_RS00990	COG2957	Belongs to the agmatine deiminase family
XPE_RS01005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XPE_RS01010	COG0539	negative regulation of cytoplasmic translation
XPE_RS01015	COG0776	regulation of translation
XPE_RS01025	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XPE_RS01030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPE_RS01040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XPE_RS01045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XPE_RS01045	COG0475	glutathione-regulated potassium exporter activity
XPE_RS01055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XPE_RS01065	COG0519	Catalyzes the synthesis of GMP from XMP
XPE_RS01065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XPE_RS01075	COG2818	Glycosylase
XPE_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS01090	COG0583	DNA-binding transcription factor activity
XPE_RS01100	COG3002	Belongs to the UPF0753 family
XPE_RS01105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XPE_RS01110	COG0583	DNA-binding transcription factor activity
XPE_RS01120	COG0633	Ferredoxin
XPE_RS01140	COG0583	DNA-binding transcription factor activity
XPE_RS01155	COG2197	response regulator
XPE_RS01160	COG4585	Histidine kinase
XPE_RS01170	COG1335	isochorismatase
XPE_RS01185	COG2814	Major facilitator Superfamily
XPE_RS01205	COG1914	H( )-stimulated, divalent metal cation uptake system
XPE_RS01220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XPE_RS01225	COG0668	transmembrane transport
XPE_RS01235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XPE_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS01255	COG1183	phosphatidylcholine synthase activity
XPE_RS01265	COG3243	poly(R)-hydroxyalkanoic acid synthase
XPE_RS01280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_RS01280	COG0723	plastoquinol--plastocyanin reductase activity
XPE_RS01290	COG2183	response to ionizing radiation
XPE_RS01295	COG0784	Response regulator, receiver
XPE_RS01295	COG2205	protein histidine kinase activity
XPE_RS01365	COG0800	Aldolase
XPE_RS01370	COG0129	dihydroxy-acid dehydratase activity
XPE_RS01375	COG0363	glucosamine-6-phosphate deaminase activity
XPE_RS01380	COG0837	glucose binding
XPE_RS01385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XPE_RS01395	COG0354	folic acid binding
XPE_RS01410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XPE_RS01425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XPE_RS01430	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XPE_RS01440	COG4591	ABC-type transport system involved in lipoprotein release permease component
XPE_RS01445	COG1136	(ABC) transporter
XPE_RS01460	COG0811	peptide transport
XPE_RS01470	COG1132	(ABC) transporter
XPE_RS01475	COG1663	tetraacyldisaccharide 4'-kinase activity
XPE_RS01480	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XPE_RS01485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XPE_RS01495	COG0322	excinuclease ABC activity
XPE_RS01500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XPE_RS01525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XPE_RS01545	COG1054	Belongs to the UPF0176 family
XPE_RS01555	COG1530	ribonuclease E activity
XPE_RS01565	COG3064	Membrane
XPE_RS01570	COG0428	transporter
XPE_RS01580	COG2154	pterin-4-alpha-carbinolamine dehydratase
XPE_RS01585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XPE_RS01585	COG0316	Belongs to the HesB IscA family
XPE_RS01600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_RS01605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_RS01620	COG0596	Alpha beta hydrolase
XPE_RS01645	COG0363	glucosamine-6-phosphate deaminase activity
XPE_RS01660	COG1073	alpha beta
XPE_RS01660	COG2226	methyltransferase
XPE_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS01700	COG0640	Transcriptional regulator
XPE_RS01735	COG2197	response regulator
XPE_RS01740	COG4585	Histidine kinase
XPE_RS01755	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XPE_RS01770	COG1858	cytochrome C peroxidase
XPE_RS01800	COG0515	serine threonine protein kinase
XPE_RS01805	COG0631	protein serine/threonine phosphatase activity
XPE_RS01990	COG4566	intracellular signal transduction
XPE_RS02000	COG5001	Diguanylate cyclase
XPE_RS02015	COG3685	Protein conserved in bacteria
XPE_RS02035	COG0243	molybdopterin cofactor binding
XPE_RS02045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XPE_RS02050	COG2223	nitrite transmembrane transporter activity
XPE_RS02055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XPE_RS02065	COG1648	precorrin-2 dehydrogenase activity
XPE_RS02065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XPE_RS02090	COG0746	molybdenum cofactor guanylyltransferase activity
XPE_RS02095	COG0303	'Molybdopterin
XPE_RS02105	COG0708	Exodeoxyribonuclease III
XPE_RS02150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XPE_RS02155	COG0303	'Molybdopterin
XPE_RS02160	COG1160	GTP binding
XPE_RS02165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_RS02175	COG1426	Protein conserved in bacteria
XPE_RS02185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XPE_RS02200	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPE_RS02200	COG1024	Enoyl-CoA hydratase
XPE_RS02205	COG0183	Belongs to the thiolase family
XPE_RS02210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XPE_RS02215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XPE_RS02230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XPE_RS02240	COG1674	ftsk spoiiie
XPE_RS02245	COG0492	ferredoxin-NADP+ reductase activity
XPE_RS02260	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XPE_RS02270	COG0542	response to heat
XPE_RS02285	COG0482	sulfurtransferase activity
XPE_RS02290	COG2915	High frequency lysogenization protein hflD homolog
XPE_RS02325	COG5002	protein histidine kinase activity
XPE_RS02345	COG0835	chemotaxis
XPE_RS02345	COG0784	Response regulator, receiver
XPE_RS02355	COG1558	bacterial-type flagellum-dependent cell motility
XPE_RS02360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XPE_RS02370	COG4787	bacterial-type flagellum-dependent cell motility
XPE_RS02385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XPE_RS02390	COG1706	bacterial-type flagellum-dependent cell motility
XPE_RS02395	COG3951	Flagellar rod assembly protein muramidase FlgJ
XPE_RS02395	COG1705	Flagellar rod assembly protein muramidase FlgJ
XPE_RS02405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XPE_RS02410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XPE_RS02415	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XPE_RS02445	COG2201	protein-glutamate methylesterase activity
XPE_RS02465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS02475	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS02510	COG1677	Flagellar hook-basal body complex protein FliE
XPE_RS02560	COG3190	flagellar
XPE_RS02580	COG1684	flagellar biosynthetic protein fliR
XPE_RS02640	COG0643	Histidine kinase
XPE_RS02640	COG0784	Response regulator, receiver
XPE_RS02640	COG2198	Histidine kinase
XPE_RS02660	COG2963	transposase activity
XPE_RS02670	COG0643	Histidine kinase
XPE_RS02670	COG2198	Histidine kinase
XPE_RS02725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XPE_RS02730	COG1360	Flagellar Motor Protein
XPE_RS02750	COG0745	RESPONSE REGULATOR receiver
XPE_RS02765	COG0840	transmembrane signaling receptor activity
XPE_RS02775	COG0840	transmembrane signaling receptor activity
XPE_RS02780	COG0840	transmembrane signaling receptor activity
XPE_RS02795	COG0840	transmembrane signaling receptor activity
XPE_RS02800	COG0840	transmembrane signaling receptor activity
XPE_RS02805	COG0840	transmembrane signaling receptor activity
XPE_RS02810	COG0840	transmembrane signaling receptor activity
XPE_RS02820	COG0840	transmembrane signaling receptor activity
XPE_RS02830	COG0840	transmembrane signaling receptor activity
XPE_RS02835	COG0840	transmembrane signaling receptor activity
XPE_RS02855	COG0835	chemotaxis
XPE_RS02865	COG0840	transmembrane signaling receptor activity
XPE_RS02875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XPE_RS02880	COG2201	protein-glutamate methylesterase activity
XPE_RS02890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_RS02925	COG0318	PFAM AMP-dependent synthetase and ligase
XPE_RS02930	COG1024	Enoyl-CoA hydratase
XPE_RS02935	COG2198	Histidine kinase
XPE_RS02935	COG2205	protein histidine kinase activity
XPE_RS02935	COG0784	Response regulator, receiver
XPE_RS02940	COG0784	Response regulator, receiver
XPE_RS02940	COG2198	Histidine kinase
XPE_RS02940	COG2205	protein histidine kinase activity
XPE_RS02950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XPE_RS02955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XPE_RS02960	COG3279	Response regulator of the LytR AlgR family
XPE_RS02970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XPE_RS02980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPE_RS02985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XPE_RS02995	COG0505	Belongs to the CarA family
XPE_RS03000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XPE_RS03010	COG2258	MOSC domain
XPE_RS03015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XPE_RS03060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPE_RS03080	COG0277	FAD linked oxidase domain protein
XPE_RS03085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPE_RS03095	COG0531	amino acid
XPE_RS03100	COG0531	amino acid
XPE_RS03105	COG0235	Class ii aldolase
XPE_RS03110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XPE_RS03115	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XPE_RS03130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XPE_RS03130	COG0140	phosphoribosyl-ATP diphosphatase activity
XPE_RS03135	COG0107	imidazoleglycerol-phosphate synthase activity
XPE_RS03140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XPE_RS03145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XPE_RS03150	COG0131	Imidazoleglycerol-phosphate dehydratase
XPE_RS03150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XPE_RS03155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPE_RS03160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XPE_RS03165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XPE_RS03175	COG0124	histidyl-tRNA synthetase
XPE_RS03180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPE_RS03190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
XPE_RS03205	COG0460	homoserine dehydrogenase
XPE_RS03205	COG0527	aspartate kinase activity
XPE_RS03210	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
XPE_RS03235	COG3210	domain, Protein
XPE_RS03235	COG3210	domain, Protein
XPE_RS03265	COG1012	belongs to the aldehyde dehydrogenase family
XPE_RS03285	COG0167	dihydroorotate dehydrogenase activity
XPE_RS03290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XPE_RS03300	COG1794	racemase activity, acting on amino acids and derivatives
XPE_RS03310	COG0671	phosphoesterase, PA-phosphatase related
XPE_RS03315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XPE_RS03330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XPE_RS03335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_RS03340	COG2203	Gaf domain
XPE_RS03340	COG3706	GGDEF domain
XPE_RS03340	COG4251	negative regulation of phosphorylation
XPE_RS03340	COG5001	Diguanylate cyclase
XPE_RS03355	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_RS03380	COG0166	Belongs to the GPI family
XPE_RS03385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XPE_RS03390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XPE_RS03395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XPE_RS03415	COG1469	GTP cyclohydrolase I activity
XPE_RS03420	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPE_RS03435	COG0477	Major facilitator Superfamily
XPE_RS03440	COG2115	Belongs to the xylose isomerase family
XPE_RS03445	COG1070	Carbohydrate kinase
XPE_RS03455	COG1501	Belongs to the glycosyl hydrolase 31 family
XPE_RS03495	COG0800	Aldolase
XPE_RS03500	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_RS03510	COG3734	2-keto-3-deoxy-galactonokinase
XPE_RS03515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XPE_RS03525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XPE_RS03540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XPE_RS03545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XPE_RS03560	COG0351	phosphomethylpyrimidine kinase
XPE_RS03585	COG0583	DNA-binding transcription factor activity
XPE_RS03590	COG1741	Belongs to the pirin family
XPE_RS03610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XPE_RS03615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XPE_RS03620	COG2137	regulation of response to DNA damage stimulus
XPE_RS03630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XPE_RS03635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XPE_RS03645	COG1546	Belongs to the CinA family
XPE_RS03650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XPE_RS03660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XPE_RS03665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XPE_RS03675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XPE_RS03680	COG1534	Rna-binding protein
XPE_RS03695	COG1238	metal cluster binding
XPE_RS03700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XPE_RS03705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XPE_RS03710	COG2840	Smr protein MutS2
XPE_RS03715	COG0585	pseudouridine synthase activity
XPE_RS03720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XPE_RS03725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XPE_RS03730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XPE_RS03735	COG0148	phosphopyruvate hydratase activity
XPE_RS03750	COG0504	CTP synthase activity
XPE_RS03775	COG0306	phosphate transporter
XPE_RS03790	COG1253	flavin adenine dinucleotide binding
XPE_RS03805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XPE_RS03810	COG2271	Major facilitator Superfamily
XPE_RS03815	COG1132	(ABC) transporter
XPE_RS03820	COG1136	(ABC) transporter
XPE_RS03840	COG0438	transferase activity, transferring glycosyl groups
XPE_RS03850	COG2264	protein methyltransferase activity
XPE_RS03875	COG1216	Glycosyl transferase, family 2
XPE_RS03875	COG1442	glycosyl transferase family 8
XPE_RS03880	COG2244	polysaccharide biosynthetic process
XPE_RS03935	COG1595	DNA-templated transcription, initiation
XPE_RS03950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XPE_RS03960	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XPE_RS03970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XPE_RS03985	COG4191	Histidine kinase
XPE_RS03985	COG0784	Response regulator, receiver
XPE_RS03990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XPE_RS04020	COG0840	transmembrane signaling receptor activity
XPE_RS04035	COG0583	DNA-binding transcription factor activity
XPE_RS04040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XPE_RS04045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XPE_RS04060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XPE_RS04065	COG0077	Prephenate dehydratase
XPE_RS04065	COG1605	Chorismate mutase
XPE_RS04070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XPE_RS04075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XPE_RS04080	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XPE_RS04120	COG1228	amidohydrolase
XPE_RS04125	COG2986	histidine ammonia-lyase
XPE_RS04135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XPE_RS04145	COG4993	Dehydrogenase
XPE_RS04155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XPE_RS04170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XPE_RS04175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XPE_RS04180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPE_RS04190	COG3115	cell septum assembly
XPE_RS04200	COG0359	binds to the 23S rRNA
XPE_RS04205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XPE_RS04210	COG0360	Binds together with S18 to 16S ribosomal RNA
XPE_RS04215	COG0316	Belongs to the HesB IscA family
XPE_RS04225	COG0017	Asparaginyl-tRNA synthetase
XPE_RS04295	COG0288	reversible hydration of carbon dioxide
XPE_RS04300	COG0662	Cupin 2, conserved barrel domain protein
XPE_RS04310	COG3844	kynureninase activity
XPE_RS04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_RS04325	COG2925	Exonuclease
XPE_RS04335	COG0667	Aldo Keto reductase
XPE_RS04350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XPE_RS04355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XPE_RS04355	COG0116	Belongs to the methyltransferase superfamily
XPE_RS04400	COG0494	nUDIX hydrolase
XPE_RS04410	COG1024	Enoyl-CoA hydratase
XPE_RS04420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XPE_RS04425	COG0659	secondary active sulfate transmembrane transporter activity
XPE_RS04450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XPE_RS04455	COG0573	inorganic phosphate transmembrane transporter activity
XPE_RS04460	COG0581	inorganic phosphate transmembrane transporter activity
XPE_RS04465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XPE_RS04470	COG0704	Plays a role in the regulation of phosphate uptake
XPE_RS04480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPE_RS04495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPE_RS04505	COG0557	exoribonuclease II activity
XPE_RS04535	COG1960	acyl-CoA dehydrogenase activity
XPE_RS04540	COG2226	methyltransferase
XPE_RS04545	COG1410	methionine synthase
XPE_RS04545	COG0646	methionine synthase
XPE_RS04550	COG0646	methionine synthase
XPE_RS04550	COG1410	methionine synthase
XPE_RS04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPE_RS04585	COG2900	Belongs to the SlyX family
XPE_RS04600	COG0386	Belongs to the glutathione peroxidase family
XPE_RS04610	COG1725	Transcriptional regulator
XPE_RS04615	COG1131	(ABC) transporter
XPE_RS04645	COG1253	flavin adenine dinucleotide binding
XPE_RS04665	COG2850	peptidyl-arginine hydroxylation
XPE_RS04700	COG1132	(ABC) transporter
XPE_RS04705	COG0583	DNA-binding transcription factor activity
XPE_RS04735	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XPE_RS04740	COG0484	heat shock protein binding
XPE_RS04745	COG0443	Heat shock 70 kDa protein
XPE_RS04750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XPE_RS04755	COG1420	regulation of RNA biosynthetic process
XPE_RS04760	COG0497	DNA recombination
XPE_RS04770	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_RS04785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XPE_RS04820	COG3706	GGDEF domain
XPE_RS04865	COG0583	DNA-binding transcription factor activity
XPE_RS04880	COG0415	Belongs to the DNA photolyase family
XPE_RS04885	COG0305	Participates in initiation and elongation during chromosome replication
XPE_RS04895	COG0367	asparagine synthase
XPE_RS04915	COG1960	acyl-CoA dehydrogenase activity
XPE_RS04930	COG0084	hydrolase, TatD family'
XPE_RS04935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XPE_RS04990	COG0386	Belongs to the glutathione peroxidase family
XPE_RS04995	COG0339	signal peptide processing
XPE_RS05055	COG2814	Major facilitator Superfamily
XPE_RS05060	COG1566	PFAM secretion protein HlyD family protein
XPE_RS05085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPE_RS05100	COG4774	siderophore transport
XPE_RS05110	COG0367	asparagine synthase
XPE_RS05115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XPE_RS05120	COG1393	Belongs to the ArsC family
XPE_RS05130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XPE_RS05170	COG0052	Belongs to the universal ribosomal protein uS2 family
XPE_RS05175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XPE_RS05185	COG0528	UMP kinase activity
XPE_RS05190	COG0233	cytoplasmic translational termination
XPE_RS05195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XPE_RS05200	COG0575	Belongs to the CDS family
XPE_RS05205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XPE_RS05210	COG0750	zinc metalloprotease
XPE_RS05225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_RS05230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPE_RS05235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_RS05240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_RS05255	COG0825	malonyl-CoA metabolic process
XPE_RS05270	COG1981	membrane
XPE_RS05290	COG1695	Transcriptional regulator
XPE_RS05310	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XPE_RS05320	COG2040	homocysteine
XPE_RS05325	COG0833	amino acid
XPE_RS05340	COG0346	lactoylglutathione lyase activity
XPE_RS05360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPE_RS05360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPE_RS05370	COG2878	Part of a membrane complex involved in electron transport
XPE_RS05385	COG1595	DNA-templated transcription, initiation
XPE_RS05410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XPE_RS05425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XPE_RS05430	COG0251	oxidation-reduction process
XPE_RS05440	COG0392	lysyltransferase activity
XPE_RS05440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XPE_RS05475	COG2814	Major facilitator Superfamily
XPE_RS05480	COG1902	pentaerythritol trinitrate reductase activity
XPE_RS05490	COG2824	Alkylphosphonate utilization operon protein PhnA
XPE_RS05500	COG1047	Peptidyl-prolyl cis-trans
XPE_RS05505	COG1077	Cell shape determining protein MreB Mrl
XPE_RS05520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XPE_RS05530	COG5487	UPF0391 membrane protein
XPE_RS05535	COG1451	nucleotide metabolic process
XPE_RS05560	COG0183	Belongs to the thiolase family
XPE_RS05595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XPE_RS05595	COG1793	dna ligase
XPE_RS05605	COG1793	dna ligase
XPE_RS05610	COG1201	RNA secondary structure unwinding
XPE_RS05620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_RS05625	COG1278	Cold shock
XPE_RS05630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XPE_RS05635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XPE_RS05640	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_RS05645	COG3046	protein related to deoxyribodipyrimidine photolyase
XPE_RS05650	COG1233	COG1233 Phytoene dehydrogenase and related
XPE_RS05655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XPE_RS05660	COG2954	triphosphatase activity
XPE_RS05665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPE_RS05680	COG1381	Involved in DNA repair and RecF pathway recombination
XPE_RS05685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XPE_RS05690	COG0571	ribonuclease III activity
XPE_RS05705	COG0481	GTPase activity
XPE_RS05710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPE_RS05725	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPE_RS05725	COG1024	Enoyl-CoA hydratase
XPE_RS05745	COG1024	Enoyl-CoA hydratase
XPE_RS05750	COG1960	acyl-CoA dehydrogenase activity
XPE_RS05770	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XPE_RS05775	COG3250	beta-galactosidase activity
XPE_RS05790	COG0840	transmembrane signaling receptor activity
XPE_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS05805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XPE_RS05815	COG3483	tryptophan 2,3-dioxygenase activity
XPE_RS05825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XPE_RS05835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XPE_RS05855	COG0534	Mate efflux family protein
XPE_RS05860	COG0335	large ribosomal subunit rRNA binding
XPE_RS05865	COG0336	Belongs to the RNA methyltransferase TrmD family
XPE_RS05870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XPE_RS05875	COG0228	four-way junction DNA binding
XPE_RS05880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XPE_RS05890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XPE_RS05895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XPE_RS05915	COG0784	Response regulator, receiver
XPE_RS05915	COG4191	Histidine kinase
XPE_RS05920	COG3437	response regulator, receiver
XPE_RS05920	COG3850	Histidine kinase
XPE_RS05920	COG4999	Histidine kinase
XPE_RS05920	COG2205	protein histidine kinase activity
XPE_RS05925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XPE_RS05935	COG2205	protein histidine kinase activity
XPE_RS05940	COG5507	3-demethylubiquinone-9 3-methyltransferase
XPE_RS05950	COG4771	TonB-dependent receptor
XPE_RS05975	COG2172	sigma factor antagonist activity
XPE_RS05980	COG1366	Belongs to the anti-sigma-factor antagonist family
XPE_RS05985	COG1366	Belongs to the anti-sigma-factor antagonist family
XPE_RS05995	COG0326	Molecular chaperone. Has ATPase activity
XPE_RS06000	COG2207	Transcriptional regulator
XPE_RS06010	COG3152	Membrane
XPE_RS06025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XPE_RS06030	COG1845	cytochrome c oxidase, subunit III
XPE_RS06035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XPE_RS06050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XPE_RS06055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XPE_RS06060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XPE_RS06065	COG0196	riboflavin kinase activity
XPE_RS06075	COG0268	Binds directly to 16S ribosomal RNA
XPE_RS06080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XPE_RS06085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XPE_RS06090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XPE_RS06095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XPE_RS06100	COG0824	Thioesterase
XPE_RS06110	COG1024	Enoyl-CoA hydratase
XPE_RS06115	COG1946	Acyl-CoA thioesterase
XPE_RS06125	COG1595	DNA-templated transcription, initiation
XPE_RS06140	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XPE_RS06160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XPE_RS06185	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XPE_RS06200	COG2197	response regulator
XPE_RS06205	COG4585	Histidine kinase
XPE_RS06220	COG0850	regulation of cytokinetic process
XPE_RS06225	COG2894	cell division
XPE_RS06230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XPE_RS06240	COG0642	Histidine kinase
XPE_RS06245	COG0745	RESPONSE REGULATOR receiver
XPE_RS06260	COG2194	sulfuric ester hydrolase activity
XPE_RS06280	COG2814	Major facilitator Superfamily
XPE_RS06305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPE_RS06305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPE_RS06310	COG2272	Belongs to the type-B carboxylesterase lipase family
XPE_RS06315	COG0656	L-ascorbic acid biosynthetic process
XPE_RS06320	COG0753	catalase activity
XPE_RS06345	COG1917	Cupin 2, conserved barrel domain protein
XPE_RS06345	COG2207	Transcriptional regulator
XPE_RS06360	COG0823	Involved in the tonB-independent uptake of proteins
XPE_RS06360	COG1506	peptidase
XPE_RS06375	COG1297	OPT oligopeptide transporter protein
XPE_RS06395	COG0587	DNA-directed DNA polymerase activity
XPE_RS06410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XPE_RS06445	COG2080	2 iron, 2 sulfur cluster binding
XPE_RS06450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XPE_RS06455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XPE_RS06480	COG0492	ferredoxin-NADP+ reductase activity
XPE_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS06500	COG3537	Alpha-1,2-mannosidase
XPE_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS06515	COG3387	PFAM Glycoside hydrolase 15-related
XPE_RS06525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XPE_RS06570	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
XPE_RS06600	COG1309	transcriptional regulator
XPE_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS06615	COG0308	aminopeptidase N
XPE_RS06620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XPE_RS06630	COG0330	HflC and HflK could
XPE_RS06635	COG0330	HflC and HflK could
XPE_RS06655	COG0678	peroxiredoxin activity
XPE_RS06665	COG4953	penicillin-binding protein 1C
XPE_RS06685	COG2373	Large extracellular alpha-helical protein
XPE_RS06730	COG3829	transcription factor binding
XPE_RS06760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XPE_RS06765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XPE_RS06795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_RS06800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XPE_RS06810	COG0424	maF-like protein
XPE_RS06825	COG0714	Associated with various cellular activities
XPE_RS06845	COG0537	adenosine 5'-monophosphoramidase activity
XPE_RS06850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XPE_RS06855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XPE_RS06880	COG4680	protein conserved in bacteria
XPE_RS06925	COG2003	Belongs to the UPF0758 family
XPE_RS07010	COG0314	molybdopterin synthase activity
XPE_RS07015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XPE_RS07020	COG0315	cyclic pyranopterin monophosphate synthase activity
XPE_RS07030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XPE_RS07035	COG1234	tRNA 3'-trailer cleavage
XPE_RS07040	COG3642	lipopolysaccharide core region biosynthetic process
XPE_RS07045	COG0859	PFAM glycosyl transferase family 9
XPE_RS07105	COG0631	protein serine/threonine phosphatase activity
XPE_RS07110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPE_RS07115	COG0328	RNA-DNA hybrid ribonuclease activity
XPE_RS07125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPE_RS07135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPE_RS07165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XPE_RS07175	COG0544	peptidyl-prolyl cis-trans isomerase activity
XPE_RS07185	COG3852	Histidine kinase
XPE_RS07215	COG0473	3-isopropylmalate dehydrogenase activity
XPE_RS07230	COG4783	chaperone-mediated protein folding
XPE_RS07245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XPE_RS07255	COG0438	transferase activity, transferring glycosyl groups
XPE_RS07260	COG0671	phosphoesterase, PA-phosphatase related
XPE_RS07265	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_RS07275	COG3291	Pkd domain containing protein
XPE_RS07280	COG2833	Protein of unknown function (DUF455)
XPE_RS07305	COG0285	dihydrofolate synthase activity
XPE_RS07310	COG0406	alpha-ribazole phosphatase activity
XPE_RS07330	COG1063	alcohol dehydrogenase
XPE_RS07350	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XPE_RS07355	COG4208	sulfate ABC transporter
XPE_RS07360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XPE_RS07365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XPE_RS07370	COG0156	8-amino-7-oxononanoate synthase activity
XPE_RS07390	COG2885	chlorophyll binding
XPE_RS07395	COG0604	alcohol dehydrogenase
XPE_RS07400	COG1902	pentaerythritol trinitrate reductase activity
XPE_RS07400	COG0446	pyridine nucleotide-disulphide oxidoreductase
XPE_RS07420	COG0625	glutathione transferase activity
XPE_RS07425	COG0039	L-malate dehydrogenase activity
XPE_RS07430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XPE_RS07435	COG1217	gtp-binding protein TYPA
XPE_RS07445	COG0154	amidase activity
XPE_RS07455	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XPE_RS07475	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XPE_RS07480	COG0203	ribosomal protein L17
XPE_RS07505	COG0201	protein transport
XPE_RS07510	COG0200	Binds to the 23S rRNA
XPE_RS07515	COG1841	ribosomal large subunit assembly
XPE_RS07525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XPE_RS07530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XPE_RS07535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XPE_RS07540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XPE_RS07545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XPE_RS07560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XPE_RS07565	COG0255	Belongs to the universal ribosomal protein uL29 family
XPE_RS07570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XPE_RS07575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XPE_RS07585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XPE_RS07590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XPE_RS07600	COG0088	Forms part of the polypeptide exit tunnel
XPE_RS07605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XPE_RS07610	COG0051	transcription antitermination factor activity, RNA binding
XPE_RS07625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPE_RS07630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XPE_RS07635	COG0049	tRNA binding
XPE_RS07640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XPE_RS07645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XPE_RS07650	COG0085	RNA polymerase activity
XPE_RS07655	COG0222	ribosome binding
XPE_RS07660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XPE_RS07665	COG0081	regulation of translation
XPE_RS07670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XPE_RS07675	COG0250	Participates in transcription elongation, termination and antitermination
XPE_RS07690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPE_RS07710	COG0012	GTP binding
XPE_RS07715	COG0193	aminoacyl-tRNA hydrolase activity
XPE_RS07720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XPE_RS07725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XPE_RS07735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XPE_RS07740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XPE_RS07750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XPE_RS07755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XPE_RS07770	COG0521	Mo-molybdopterin cofactor biosynthetic process
XPE_RS07785	COG1254	Belongs to the acylphosphatase family
XPE_RS07790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XPE_RS07795	COG1295	ribonuclease BN
XPE_RS07820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XPE_RS07825	COG1404	Belongs to the peptidase S8 family
XPE_RS07835	COG1404	Belongs to the peptidase S8 family
XPE_RS07840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XPE_RS07855	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XPE_RS07880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XPE_RS07895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPE_RS07895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPE_RS07915	COG2890	protein-(glutamine-N5) methyltransferase activity
XPE_RS07925	COG3634	alkyl hydroperoxide reductase activity
XPE_RS07930	COG0583	DNA-binding transcription factor activity
XPE_RS07940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPE_RS07945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XPE_RS07955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XPE_RS07965	COG2197	response regulator
XPE_RS07975	COG0745	RESPONSE REGULATOR receiver
XPE_RS07990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPE_RS08000	COG0697	spore germination
XPE_RS08025	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XPE_RS08035	COG3386	PFAM SMP-30 Gluconolaconase
XPE_RS08055	COG1024	Enoyl-CoA hydratase
XPE_RS08065	COG0318	PFAM AMP-dependent synthetase and ligase
XPE_RS08070	COG0583	DNA-binding transcription factor activity
XPE_RS08075	COG3384	dioxygenase
XPE_RS08105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_RS08110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_RS08125	COG2096	Adenosyltransferase
XPE_RS08130	COG0123	including yeast histone deacetylase and acetoin utilization protein
XPE_RS08135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XPE_RS08140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPE_RS08145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XPE_RS08150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XPE_RS08155	COG2967	ApaG domain
XPE_RS08160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XPE_RS08175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XPE_RS08180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XPE_RS08200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XPE_RS08210	COG0642	Histidine kinase
XPE_RS08225	COG4181	ATPase activity
XPE_RS08235	COG2175	clavaminate synthase activity
XPE_RS08245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XPE_RS08250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XPE_RS08270	COG4771	TonB-dependent receptor
XPE_RS08280	COG0667	Aldo Keto reductase
XPE_RS08290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XPE_RS08295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPE_RS08305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPE_RS08310	COG4106	trans-aconitate 2-methyltransferase activity
XPE_RS08320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XPE_RS08360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XPE_RS08370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XPE_RS08375	COG2226	methyltransferase
XPE_RS08405	COG0366	Alpha amylase catalytic
XPE_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS08425	COG3321	synthase
XPE_RS08425	COG0604	alcohol dehydrogenase
XPE_RS08440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XPE_RS08450	COG0494	nUDIX hydrolase
XPE_RS08455	COG0653	protein targeting
XPE_RS08460	COG0739	heme binding
XPE_RS08470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XPE_RS08485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XPE_RS08490	COG1181	Belongs to the D-alanine--D-alanine ligase family
XPE_RS08495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPE_RS08500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XPE_RS08510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPE_RS08515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XPE_RS08520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XPE_RS08530	COG3116	cell division
XPE_RS08535	COG0275	rRNA processing
XPE_RS08575	COG0792	nuclease activity
XPE_RS08580	COG1988	membrane-bound metal-dependent
XPE_RS08585	COG0277	FAD linked oxidase domain protein
XPE_RS08595	COG0745	RESPONSE REGULATOR receiver
XPE_RS08600	COG2205	protein histidine kinase activity
XPE_RS08610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XPE_RS08615	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XPE_RS08645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XPE_RS08650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPE_RS08655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XPE_RS08675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPE_RS08675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPE_RS08685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XPE_RS08690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XPE_RS08700	COG0488	(ABC) transporter
XPE_RS08715	COG3791	Glutathione-dependent formaldehyde-activating
XPE_RS08745	COG2205	protein histidine kinase activity
XPE_RS08755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XPE_RS08785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XPE_RS08790	COG1012	belongs to the aldehyde dehydrogenase family
XPE_RS08795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XPE_RS08800	COG0617	tRNA 3'-terminal CCA addition
XPE_RS08815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XPE_RS08820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XPE_RS08825	COG1609	Transcriptional regulator
XPE_RS08835	COG2188	Transcriptional regulator
XPE_RS08860	COG4795	General secretion pathway protein
XPE_RS08880	COG1459	type II secretion system
XPE_RS08935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XPE_RS08940	COG4191	Histidine kinase
XPE_RS08945	COG0784	Response regulator, receiver
XPE_RS08950	COG4251	negative regulation of phosphorylation
XPE_RS08955	COG2823	Periplasmic or secreted lipoprotein
XPE_RS08960	COG0673	inositol 2-dehydrogenase activity
XPE_RS08965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XPE_RS09000	COG1051	belongs to the nudix hydrolase family
XPE_RS09000	COG1056	cytidyltransferase-related domain
XPE_RS09010	COG0583	DNA-binding transcription factor activity
XPE_RS09025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XPE_RS09030	COG0321	lipoyl(octanoyl) transferase activity
XPE_RS09035	COG2921	Belongs to the UPF0250 family
XPE_RS09045	COG1686	Belongs to the peptidase S11 family
XPE_RS09055	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XPE_RS09060	COG2951	lytic endotransglycosylase activity
XPE_RS09075	COG0772	Belongs to the SEDS family
XPE_RS09090	COG1792	Involved in formation and maintenance of cell shape
XPE_RS09095	COG1077	Cell shape determining protein MreB Mrl
XPE_RS09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPE_RS09105	COG3284	Transcriptional regulator
XPE_RS09115	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
XPE_RS09155	COG0308	aminopeptidase N
XPE_RS09160	COG3300	MHYT domain
XPE_RS09160	COG5001	Diguanylate cyclase
XPE_RS09190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XPE_RS09195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XPE_RS09200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XPE_RS09210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XPE_RS09220	COG2832	Protein of unknown function (DUF454)
XPE_RS09230	COG0436	Aminotransferase
XPE_RS09235	COG1505	serine-type exopeptidase activity
XPE_RS09275	COG0181	hydroxymethylbilane synthase activity
XPE_RS09285	COG3275	phosphorelay sensor kinase activity
XPE_RS09295	COG2943	transferase activity, transferring hexosyl groups
XPE_RS09315	COG0659	secondary active sulfate transmembrane transporter activity
XPE_RS09320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_RS09320	COG5297	Belongs to the glycosyl hydrolase family 6
XPE_RS09325	COG0840	transmembrane signaling receptor activity
XPE_RS09365	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XPE_RS09380	COG0598	Magnesium transport protein CorA
XPE_RS09390	COG1113	amino acid transport
XPE_RS09410	COG0697	spore germination
XPE_RS09435	COG1959	2 iron, 2 sulfur cluster binding
XPE_RS09490	COG0435	Glutathione S-transferase
XPE_RS09500	COG4221	oxidoreductase activity
XPE_RS09690	COG0546	phosphoglycolate phosphatase activity
XPE_RS09695	COG1802	Transcriptional regulator
XPE_RS09705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XPE_RS09730	COG3052	prosthetic group binding
XPE_RS09755	COG2353	YceI-like domain
XPE_RS09760	COG0778	Nitroreductase
XPE_RS09790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XPE_RS09795	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XPE_RS09820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPE_RS09835	COG0459	protein refolding
XPE_RS09850	COG2356	endonuclease I
XPE_RS09860	COG1324	tolerance protein
XPE_RS09870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XPE_RS09875	COG0511	ligase activity, forming carbon-carbon bonds
XPE_RS09885	COG0439	Biotin carboxylase
XPE_RS09905	COG2264	protein methyltransferase activity
XPE_RS09935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XPE_RS09940	COG4589	Belongs to the CDS family
XPE_RS09965	COG0671	phosphoesterase, PA-phosphatase related
XPE_RS09965	COG2453	phosphatase
XPE_RS09970	COG2267	carboxylic ester hydrolase activity
XPE_RS09975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XPE_RS09980	COG0138	bifunctional purine biosynthesis protein purh
XPE_RS09990	COG0151	Belongs to the GarS family
XPE_RS09995	COG1289	transmembrane transporter activity
XPE_RS10000	COG2814	Major facilitator Superfamily
XPE_RS10025	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XPE_RS10045	COG0316	Belongs to the HesB IscA family
XPE_RS10085	COG1051	belongs to the nudix hydrolase family
XPE_RS10100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XPE_RS10110	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XPE_RS10120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XPE_RS10125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPE_RS10135	COG0134	indole-3-glycerol-phosphate synthase activity
XPE_RS10140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XPE_RS10170	COG1597	lipid kinase activity
XPE_RS10175	COG0456	acetyltransferase
XPE_RS10185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XPE_RS10190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XPE_RS10210	COG3179	chitinase
XPE_RS10230	COG2111	Na H antiporter
XPE_RS10230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XPE_RS10235	COG1006	Multisubunit Na H antiporter MnhC subunit
XPE_RS10240	COG0651	ATP synthesis coupled electron transport
XPE_RS10250	COG2212	antiporter activity
XPE_RS10255	COG1320	monovalent cation:proton antiporter activity
XPE_RS10270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XPE_RS10275	COG2852	Protein conserved in bacteria
XPE_RS10295	COG3104	oligopeptide transport
XPE_RS10300	COG3483	tryptophan 2,3-dioxygenase activity
XPE_RS10310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XPE_RS10325	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPE_RS10340	COG0513	Belongs to the DEAD box helicase family
XPE_RS10355	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS10360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_RS10395	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS10400	COG0702	epimerase
XPE_RS10425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XPE_RS10430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XPE_RS10435	COG0297	glycogen (starch) synthase activity
XPE_RS10445	COG2354	Protein conserved in bacteria
XPE_RS10455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XPE_RS10465	COG1368	sulfuric ester hydrolase activity
XPE_RS10470	COG1511	domain protein
XPE_RS10470	COG3264	Mechanosensitive ion channel
XPE_RS10500	COG2801	Transposase and inactivated derivatives
XPE_RS10505	COG2963	transposase activity
XPE_RS10570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XPE_RS10655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XPE_RS10660	COG1040	competence protein
XPE_RS10665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XPE_RS10670	COG0156	8-amino-7-oxononanoate synthase activity
XPE_RS10680	COG2267	carboxylic ester hydrolase activity
XPE_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS10710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XPE_RS10725	COG0445	tRNA wobble uridine modification
XPE_RS10735	COG0657	acetylesterase activity
XPE_RS10745	COG1414	Transcriptional regulator
XPE_RS10760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XPE_RS10765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_RS10775	COG3485	protocatechuate 3,4-dioxygenase
XPE_RS10780	COG3485	protocatechuate 3,4-dioxygenase
XPE_RS10790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XPE_RS10795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XPE_RS10820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XPE_RS10825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XPE_RS10880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XPE_RS10895	COG0129	dihydroxy-acid dehydratase activity
XPE_RS10915	COG2801	Transposase and inactivated derivatives
XPE_RS10990	COG1733	regulation of RNA biosynthetic process
XPE_RS10995	COG0702	epimerase
XPE_RS11035	COG0583	DNA-binding transcription factor activity
XPE_RS11040	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPE_RS11065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_RS11070	COG2205	protein histidine kinase activity
XPE_RS11075	COG0745	RESPONSE REGULATOR receiver
XPE_RS11095	COG1902	pentaerythritol trinitrate reductase activity
XPE_RS11100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XPE_RS11105	COG2267	carboxylic ester hydrolase activity
XPE_RS11115	COG2814	Major facilitator Superfamily
XPE_RS11120	COG0583	DNA-binding transcription factor activity
XPE_RS11135	COG0084	hydrolase, TatD family'
XPE_RS11160	COG2252	PERMEase
XPE_RS11200	COG0583	DNA-binding transcription factor activity
XPE_RS11210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XPE_RS11230	COG2072	flavoprotein involved in K transport
XPE_RS11240	COG4807	Protein conserved in bacteria
XPE_RS11250	COG1643	Atp-dependent helicase
XPE_RS11260	COG1187	pseudouridine synthase activity
XPE_RS11275	COG2130	NADP-dependent
XPE_RS11295	COG1764	response to oxidative stress
XPE_RS11300	COG1846	Transcriptional regulator
XPE_RS11305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XPE_RS11315	COG0697	spore germination
XPE_RS11325	COG0523	cobalamin synthesis protein
XPE_RS11380	COG1960	acyl-CoA dehydrogenase activity
XPE_RS11385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XPE_RS11390	COG4770	biotin carboxylase activity
XPE_RS11420	COG2224	Isocitrate lyase
XPE_RS11425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XPE_RS11430	COG0583	DNA-binding transcription factor activity
XPE_RS11435	COG0475	glutathione-regulated potassium exporter activity
XPE_RS11465	COG0339	signal peptide processing
XPE_RS11470	COG1446	asparaginase
XPE_RS11490	COG0564	pseudouridine synthase activity
XPE_RS11500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XPE_RS11510	COG1181	Belongs to the D-alanine--D-alanine ligase family
XPE_RS11520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPE_RS11525	COG0318	PFAM AMP-dependent synthetase and ligase
XPE_RS11530	COG0727	PFAM Uncharacterised protein family (UPF0153)
XPE_RS11535	COG0596	Alpha beta hydrolase
XPE_RS11540	COG3177	Filamentation induced by cAMP protein fic
XPE_RS11545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_RS11560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XPE_RS11585	COG4191	Histidine kinase
XPE_RS11590	COG0028	Belongs to the TPP enzyme family
XPE_RS11605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XPE_RS11610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XPE_RS11615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPE_RS11650	COG0183	Belongs to the thiolase family
XPE_RS11665	COG2032	superoxide dismutase activity
XPE_RS11670	COG2032	superoxide dismutase activity
XPE_RS11675	COG2204	response regulator
XPE_RS11680	COG3852	Histidine kinase
XPE_RS11685	COG0004	ammonium transporteR
XPE_RS11690	COG0347	Belongs to the P(II) protein family
XPE_RS11695	COG0174	glutamine synthetase
XPE_RS11705	COG1968	undecaprenyl-diphosphatase activity
XPE_RS11750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_RS11760	COG2062	phosphohistidine phosphatase, SixA
XPE_RS11765	COG0489	protein tyrosine kinase activity
XPE_RS11805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XPE_RS11820	COG1125	glycine betaine transport
XPE_RS11835	COG1119	ATPase activity
XPE_RS11845	COG1473	amidohydrolase
XPE_RS11850	COG1752	Esterase of the alpha-beta hydrolase superfamily
XPE_RS11860	COG1522	sequence-specific DNA binding
XPE_RS11865	COG3186	Phenylalanine-4-hydroxylase
XPE_RS11875	COG2755	lipolytic protein G-D-S-L family
XPE_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS11890	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XPE_RS11895	COG1609	Transcriptional regulator
XPE_RS11900	COG3507	Belongs to the glycosyl hydrolase 43 family
XPE_RS11915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XPE_RS11925	COG0657	acetylesterase activity
XPE_RS11925	COG2755	lipolytic protein G-D-S-L family
XPE_RS11930	COG2272	Belongs to the type-B carboxylesterase lipase family
XPE_RS11945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XPE_RS11950	COG0366	Alpha amylase catalytic
XPE_RS11955	COG0366	Alpha amylase catalytic
XPE_RS12030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPE_RS12040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XPE_RS12045	COG3710	Transcriptional regulator
XPE_RS12065	COG2197	response regulator
XPE_RS12070	COG4585	Histidine kinase
XPE_RS12075	COG1755	Isoprenylcysteine carboxyl methyltransferase
XPE_RS12090	COG1304	FMN binding
XPE_RS12115	COG1012	belongs to the aldehyde dehydrogenase family
XPE_RS12130	COG4772	TonB-dependent receptor
XPE_RS12140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XPE_RS12195	COG0714	Associated with various cellular activities
XPE_RS12235	COG0477	Major facilitator Superfamily
XPE_RS12245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XPE_RS12290	COG3237	CsbD-like
XPE_RS12340	COG2249	NAD(P)H dehydrogenase (quinone) activity
XPE_RS12355	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS12360	COG0300	oxidoreductase activity
XPE_RS12380	COG1272	protein, Hemolysin III
XPE_RS12385	COG1205	dead DEAH box helicase
XPE_RS12385	COG1111	helicase
XPE_RS12480	COG0070	glutamate synthase
XPE_RS12480	COG0069	glutamate synthase activity
XPE_RS12480	COG0067	glutamate synthase
XPE_RS12485	COG0493	'glutamate synthase
XPE_RS12495	COG1064	alcohol dehydrogenase
XPE_RS12505	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_RS12510	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_RS12515	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_RS12525	COG2234	aminopeptidase activity
XPE_RS12535	COG4942	peptidase
XPE_RS12540	COG0793	Belongs to the peptidase S41A family
XPE_RS12585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_RS12595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XPE_RS12630	COG0501	Belongs to the peptidase M48B family
XPE_RS12640	COG0187	DNA topoisomerase II activity
XPE_RS12645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XPE_RS12655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XPE_RS12670	COG0594	ribonuclease P activity
XPE_RS12675	COG0706	membrane insertase activity
XPE_RS12680	COG0726	polysaccharide deacetylase
XPE_RS12685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XPE_RS12700	COG0584	glycerophosphoryl diester phosphodiesterase
XPE_RS12715	COG0861	Integral membrane protein TerC family
XPE_RS12720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XPE_RS12735	COG2271	Major facilitator Superfamily
XPE_RS12740	COG1929	Belongs to the glycerate kinase type-1 family
XPE_RS12745	COG3835	regulator
XPE_RS12750	COG2203	Gaf domain
XPE_RS12750	COG2199	diguanylate cyclase activity
XPE_RS12765	COG3537	Alpha-1,2-mannosidase
XPE_RS12770	COG0531	amino acid
XPE_RS12795	COG0604	alcohol dehydrogenase
XPE_RS12800	COG1322	Protein conserved in bacteria
XPE_RS12810	COG0386	Belongs to the glutathione peroxidase family
XPE_RS12820	COG2853	Lipoprotein
XPE_RS12835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPE_RS12840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XPE_RS12845	COG1127	ABC transporter
XPE_RS12880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XPE_RS12885	COG1074	ATP-dependent DNA helicase activity
XPE_RS12895	COG3549	Plasmid maintenance system killer
XPE_RS12945	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS12955	COG1309	transcriptional regulator
XPE_RS12975	COG2801	Transposase and inactivated derivatives
XPE_RS13005	COG0564	pseudouridine synthase activity
XPE_RS13065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_RS13075	COG4221	oxidoreductase activity
XPE_RS13080	COG0583	DNA-binding transcription factor activity
XPE_RS13090	COG0477	Major facilitator Superfamily
XPE_RS13095	COG1289	transmembrane transporter activity
XPE_RS13105	COG1566	PFAM secretion protein HlyD family protein
XPE_RS13120	COG0302	gtp cyclohydrolase
XPE_RS13140	COG0730	response to heat
XPE_RS13145	COG3012	SEC-C Motif Domain Protein
XPE_RS13155	COG0676	glucose-6-phosphate 1-epimerase activity
XPE_RS13175	COG3135	benzoate transporter
XPE_RS13205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XPE_RS13215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XPE_RS13225	COG1435	thymidine kinase activity
XPE_RS13230	COG0210	DNA helicase
XPE_RS13245	COG3132	Protein of unknown function, DUF480
XPE_RS13255	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XPE_RS13260	COG0284	orotidine-5'-phosphate decarboxylase activity
XPE_RS13290	COG2937	Belongs to the GPAT DAPAT family
XPE_RS13335	COG2211	Major facilitator Superfamily
XPE_RS13350	COG3693	PFAM glycoside hydrolase, family 10
XPE_RS13360	COG3693	PFAM glycoside hydrolase, family 10
XPE_RS13365	COG1904	glucuronate isomerase
XPE_RS13370	COG3250	beta-galactosidase activity
XPE_RS13380	COG3386	PFAM SMP-30 Gluconolaconase
XPE_RS13405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPE_RS13460	COG0246	Mannitol dehydrogenase
XPE_RS13465	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_RS13475	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_RS13485	COG3661	Belongs to the glycosyl hydrolase 67 family
XPE_RS13495	COG2115	Belongs to the xylose isomerase family
XPE_RS13505	COG0037	tRNA processing
XPE_RS13510	COG2974	May be involved in recombination
XPE_RS13540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XPE_RS13550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPE_RS13555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPE_RS13560	COG0805	protein transport
XPE_RS13570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XPE_RS13570	COG0519	Catalyzes the synthesis of GMP from XMP
XPE_RS13585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XPE_RS13590	COG0752	glycyl-tRNA synthetase alpha subunit
XPE_RS13600	COG0457	Tetratricopeptide repeat
XPE_RS13610	COG4771	TonB-dependent receptor
XPE_RS13615	COG0729	surface antigen
XPE_RS13620	COG2911	Protein conserved in bacteria
XPE_RS13640	COG3209	COG3209 Rhs family protein
XPE_RS13645	COG2963	transposase activity
XPE_RS13655	COG3039	Transposase
XPE_RS13675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_RS13685	COG3265	gluconokinase activity
XPE_RS13690	COG2211	Major facilitator Superfamily
XPE_RS13695	COG3459	Glycosyltransferase 36 associated
XPE_RS13710	COG2205	protein histidine kinase activity
XPE_RS13715	COG1971	Probably functions as a manganese efflux pump
XPE_RS13725	COG1414	Transcriptional regulator
XPE_RS13730	COG0738	Major facilitator superfamily
XPE_RS13735	COG3254	rhamnose metabolic process
XPE_RS13740	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_RS13750	COG0179	Fumarylacetoacetate (FAA) hydrolase
XPE_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS13775	COG3507	Belongs to the glycosyl hydrolase 43 family
XPE_RS13810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XPE_RS13820	COG3162	membrane
XPE_RS13825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPE_RS13835	COG0708	Exodeoxyribonuclease III
XPE_RS13850	COG2091	lysine biosynthetic process via aminoadipic acid
XPE_RS13860	COG3540	Alkaline phosphatase
XPE_RS13865	COG0357	Ribosomal RNA small subunit methyltransferase G
XPE_RS13890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_RS13915	COG2159	amidohydrolase
XPE_RS13930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XPE_RS13935	COG0583	DNA-binding transcription factor activity
XPE_RS13940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_RS13955	COG0210	DNA helicase
XPE_RS14120	COG0583	DNA-binding transcription factor activity
XPE_RS14125	COG0667	Aldo Keto reductase
XPE_RS14150	COG0631	protein serine/threonine phosphatase activity
XPE_RS14155	COG0515	serine threonine protein kinase
XPE_RS14195	COG0408	coproporphyrinogen oxidase activity
XPE_RS14240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XPE_RS14255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPE_RS14295	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS14315	COG0463	Glycosyl transferase, family 2
XPE_RS14325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPE_RS14330	COG3100	YcgL domain-containing protein
XPE_RS14340	COG3387	PFAM Glycoside hydrolase 15-related
XPE_RS14345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XPE_RS14370	COG2239	Acts as a magnesium transporter
XPE_RS14375	COG0045	succinate-CoA ligase (ADP-forming) activity
XPE_RS14375	COG1042	CoA-binding domain protein
XPE_RS14375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPE_RS14390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XPE_RS14400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XPE_RS14405	COG0716	FMN binding
XPE_RS14430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XPE_RS14435	COG0842	Transport permease protein
XPE_RS14440	COG1131	(ABC) transporter
XPE_RS14445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPE_RS14470	COG1476	TRANSCRIPTIONal
XPE_RS14480	COG4555	ABC transporter
XPE_RS14515	COG0625	glutathione transferase activity
XPE_RS14565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XPE_RS14580	COG1199	ATP-dependent helicase activity
XPE_RS14615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPE_RS14660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XPE_RS14660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XPE_RS14665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XPE_RS14680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XPE_RS14720	COG3237	CsbD-like
XPE_RS14725	COG0180	Tryptophanyl-tRNA synthetase
XPE_RS14730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPE_RS14750	COG0697	spore germination
XPE_RS14775	COG1136	(ABC) transporter
XPE_RS14780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_RS14785	COG4585	Histidine kinase
XPE_RS14790	COG2197	response regulator
XPE_RS14805	COG0753	catalase activity
XPE_RS14820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPE_RS14825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPE_RS14850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPE_RS14870	COG0642	Histidine kinase
XPE_RS14880	COG1090	epimerase
XPE_RS14915	COG1690	Belongs to the RtcB family
XPE_RS14950	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XPE_RS14965	COG0606	chelatase, subunit chli
XPE_RS14985	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XPE_RS14985	COG3291	Pkd domain containing protein
XPE_RS15005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XPE_RS15010	COG1166	arginine decarboxylase activity
XPE_RS15015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XPE_RS15025	COG2755	lipolytic protein G-D-S-L family
XPE_RS15025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XPE_RS15030	COG4221	oxidoreductase activity
XPE_RS15045	COG0018	arginyl-trna synthetase
XPE_RS15050	COG2003	Belongs to the UPF0758 family
XPE_RS15055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XPE_RS15060	COG0756	dUTP diphosphatase activity
XPE_RS15080	COG0463	Glycosyl transferase, family 2
XPE_RS15095	COG1475	DNA binding
XPE_RS15100	COG1192	Involved in chromosome partitioning
XPE_RS15110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XPE_RS15115	COG0708	Exodeoxyribonuclease III
XPE_RS15120	COG2211	Major facilitator Superfamily
XPE_RS15130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XPE_RS15135	COG0739	heme binding
XPE_RS15140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XPE_RS15180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XPE_RS15195	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XPE_RS15225	COG0109	protoheme IX farnesyltransferase activity
XPE_RS15240	COG0358	DNA primase activity
XPE_RS15245	COG1295	ribonuclease BN
XPE_RS15255	COG1610	YqeY-like protein
XPE_RS15265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XPE_RS15270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XPE_RS15280	COG2133	pyrroloquinoline quinone binding
XPE_RS15285	COG4682	membrane
XPE_RS15300	COG0531	amino acid
XPE_RS15310	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_RS15320	COG3023	N-Acetylmuramoyl-L-alanine amidase
XPE_RS15325	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XPE_RS15370	COG5383	Protein conserved in bacteria
XPE_RS15380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_RS15385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_RS15390	COG1473	amidohydrolase
XPE_RS15395	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPE_RS15395	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPE_RS15400	COG1652	LysM domain
XPE_RS15420	COG0583	DNA-binding transcription factor activity
XPE_RS15425	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XPE_RS15440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XPE_RS15445	COG3118	belongs to the thioredoxin family
XPE_RS15455	COG2884	Cell division ATP-binding protein ftsE
XPE_RS15460	COG2177	Part of the ABC transporter FtsEX involved in
XPE_RS15465	COG3437	response regulator, receiver
XPE_RS15470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XPE_RS15475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XPE_RS15480	COG2860	membrane
XPE_RS15485	COG1252	NADH dehydrogenase
XPE_RS15500	COG0625	glutathione transferase activity
XPE_RS15505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XPE_RS15525	COG0534	Mate efflux family protein
XPE_RS15530	COG0616	signal peptide processing
XPE_RS15545	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS15560	COG0009	L-threonylcarbamoyladenylate synthase
XPE_RS15565	COG1754	DNA topoisomerase type I activity
XPE_RS15565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XPE_RS15585	COG0758	DNA mediated transformation
XPE_RS15590	COG1652	LysM domain
XPE_RS15595	COG0242	peptide deformylase activity
XPE_RS15600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XPE_RS15605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XPE_RS15605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPE_RS15655	COG1560	Kdo2-lipid A biosynthetic process
XPE_RS15660	COG1490	D-aminoacyl-tRNA deacylase activity
XPE_RS15665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XPE_RS15905	COG4695	Portal protein
XPE_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS15950	COG0024	Methionine aminopeptidase
XPE_RS15960	COG0038	chloride channel
XPE_RS15965	COG0659	secondary active sulfate transmembrane transporter activity
XPE_RS15995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XPE_RS16000	COG0583	DNA-binding transcription factor activity
XPE_RS16020	COG0251	oxidation-reduction process
XPE_RS16095	COG1063	alcohol dehydrogenase
XPE_RS16110	COG1132	(ABC) transporter
XPE_RS16130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XPE_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS16150	COG1294	oxidase, subunit
XPE_RS16155	COG1271	oxidase subunit
XPE_RS16170	COG2204	response regulator
XPE_RS16205	COG3546	catalase activity
XPE_RS16210	COG3685	Protein conserved in bacteria
XPE_RS16230	COG2972	Histidine kinase
XPE_RS16245	COG0531	amino acid
XPE_RS16260	COG3590	peptidase
XPE_RS16275	COG0667	Aldo Keto reductase
XPE_RS16285	COG0583	DNA-binding transcription factor activity
XPE_RS16290	COG3384	dioxygenase
XPE_RS16305	COG1573	uracil-dna glycosylase
XPE_RS16310	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XPE_RS16320	COG0025	NhaP-type Na H and K H
XPE_RS16325	COG1131	(ABC) transporter
XPE_RS16330	COG0842	Transport permease protein
XPE_RS16390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_RS16395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XPE_RS16415	COG2202	Pas domain
XPE_RS16415	COG2205	protein histidine kinase activity
XPE_RS16435	COG2813	Specifically methylates the guanine in position
XPE_RS16440	COG1187	pseudouridine synthase activity
XPE_RS16445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPE_RS16470	COG2198	Histidine kinase
XPE_RS16470	COG0784	Response regulator, receiver
XPE_RS16470	COG5002	protein histidine kinase activity
XPE_RS16480	COG1666	GTP binding
XPE_RS16485	COG0697	spore germination
XPE_RS16490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XPE_RS16495	COG2011	ABC-type metal ion transport system permease component
XPE_RS16535	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPE_RS16545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPE_RS16565	COG0356	it plays a direct role in the translocation of protons across the membrane
XPE_RS16575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XPE_RS16580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XPE_RS16585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XPE_RS16590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XPE_RS16595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XPE_RS16600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XPE_RS16615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XPE_RS16620	COG4191	Histidine kinase
XPE_RS16635	COG0577	efflux transmembrane transporter activity
XPE_RS16640	COG0577	efflux transmembrane transporter activity
XPE_RS16645	COG1136	(ABC) transporter
XPE_RS16650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_RS16655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XPE_RS16705	COG0339	signal peptide processing
XPE_RS16720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPE_RS16730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XPE_RS16745	COG1956	GAF domain-containing protein
XPE_RS16750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XPE_RS16760	COG0720	synthase
XPE_RS16765	COG0513	Belongs to the DEAD box helicase family
XPE_RS16780	COG0625	glutathione transferase activity
XPE_RS16810	COG0626	cystathionine gamma-synthase activity
XPE_RS16840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPE_RS16850	COG0277	FAD linked oxidase domain protein
XPE_RS16855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XPE_RS16855	COG0546	phosphoglycolate phosphatase activity
XPE_RS16870	COG2086	electron transfer activity
XPE_RS16900	COG0662	Cupin 2, conserved barrel domain protein
XPE_RS16900	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XPE_RS16905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XPE_RS16910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XPE_RS16950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPE_RS16950	COG3218	ABC-type transport auxiliary lipoprotein component
XPE_RS16955	COG1127	ABC transporter
XPE_RS16960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XPE_RS16975	COG0442	prolyl-tRNA aminoacylation
XPE_RS16985	COG1183	phosphatidylcholine synthase activity
XPE_RS17015	COG0525	valine-tRNA ligase activity
XPE_RS17030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPE_RS17040	COG0795	lipopolysaccharide-transporting ATPase activity
XPE_RS17055	COG4974	Belongs to the 'phage' integrase family
XPE_RS17065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XPE_RS17075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XPE_RS17075	COG0047	phosphoribosylformylglycinamidine synthase activity
XPE_RS17085	COG5295	Hep Hag repeat protein
XPE_RS17090	COG1404	Belongs to the peptidase S8 family
XPE_RS17095	COG5295	Hep Hag repeat protein
XPE_RS17100	COG1404	Belongs to the peptidase S8 family
XPE_RS17105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XPE_RS17115	COG1459	type II secretion system
XPE_RS17120	COG2165	general secretion pathway protein
XPE_RS17125	COG4970	Tfp pilus assembly protein FimT
XPE_RS17130	COG2165	general secretion pathway protein
XPE_RS17135	COG4795	General secretion pathway protein
XPE_RS17140	COG3156	type II secretion system protein K
XPE_RS17145	COG3166	PFAM Fimbrial assembly family protein
XPE_RS17160	COG1450	Type ii and iii secretion system protein
XPE_RS17170	COG2188	Transcriptional regulator
XPE_RS17215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XPE_RS17230	COG1215	transferase activity, transferring glycosyl groups
XPE_RS17235	COG1215	transferase activity, transferring glycosyl groups
XPE_RS17240	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XPE_RS17245	COG0457	Tetratricopeptide repeat
XPE_RS17275	COG0242	peptide deformylase activity
XPE_RS17280	COG1307	EDD domain protein, DegV family
XPE_RS17305	COG0402	S-adenosylhomocysteine deaminase activity
XPE_RS17310	COG3964	amidohydrolase
XPE_RS17325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XPE_RS17330	COG0726	polysaccharide deacetylase
XPE_RS17345	COG0436	Aminotransferase
XPE_RS17350	COG1162	GTPase activity
XPE_RS17375	COG2211	Major facilitator Superfamily
XPE_RS17380	COG1609	Transcriptional regulator
XPE_RS17385	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS17390	COG2851	Citrate transporter
XPE_RS17410	COG0642	Histidine kinase
XPE_RS17420	COG2197	response regulator
XPE_RS17435	COG0667	Aldo Keto reductase
XPE_RS17440	COG0583	DNA-binding transcription factor activity
XPE_RS17465	COG1301	dicarboxylic acid transport
XPE_RS17470	COG0281	malic enzyme
XPE_RS17470	COG0280	phosphate acetyltransferase
XPE_RS17495	COG1560	Kdo2-lipid A biosynthetic process
XPE_RS17505	COG1519	Transferase
XPE_RS17510	COG1538	Outer membrane efflux protein
XPE_RS17515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XPE_RS17535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XPE_RS17540	COG0066	3-isopropylmalate dehydratase activity
XPE_RS17545	COG0473	3-isopropylmalate dehydrogenase activity
XPE_RS17550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XPE_RS17570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XPE_RS17575	COG0405	Gamma-glutamyltransferase
XPE_RS17595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XPE_RS17600	COG3710	Transcriptional regulator
XPE_RS17620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XPE_RS17630	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XPE_RS17645	COG0563	adenylate kinase activity
XPE_RS17650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPE_RS17660	COG3781	membrane
XPE_RS17665	COG0671	phosphoesterase, PA-phosphatase related
XPE_RS17675	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS17680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPE_RS17685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XPE_RS17715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPE_RS17720	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XPE_RS17735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPE_RS17755	COG0352	thiamine-phosphate diphosphorylase activity
XPE_RS17760	COG1773	rubredoxin
XPE_RS17765	COG2912	Transglutaminase-like superfamily
XPE_RS17775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XPE_RS17785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XPE_RS17805	COG3079	Belongs to the UPF0149 family
XPE_RS17810	COG0006	proline dipeptidase activity
XPE_RS17820	COG0006	proline dipeptidase activity
XPE_RS17835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XPE_RS17840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XPE_RS17850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XPE_RS17855	COG1561	YicC-like family, N-terminal region
XPE_RS17860	COG0194	GDP metabolic process
XPE_RS17870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPE_RS17880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XPE_RS17885	COG1957	nucleoside hydrolase
XPE_RS17905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XPE_RS17935	COG0714	Associated with various cellular activities
XPE_RS17955	COG2304	oxidoreductase activity
XPE_RS17970	COG1301	dicarboxylic acid transport
XPE_RS17975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XPE_RS17980	COG4773	Receptor
XPE_RS17985	COG0739	heme binding
XPE_RS17990	COG1376	ErfK ybiS ycfS ynhG family protein
XPE_RS18025	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XPE_RS18030	COG4149	molybdate abc transporter
XPE_RS18035	COG0725	ABC transporter, periplasmic molybdate-binding protein
XPE_RS18050	COG3047	cAMP biosynthetic process
XPE_RS18065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XPE_RS18085	COG0126	phosphoglycerate kinase activity
XPE_RS18095	COG0469	pyruvate kinase activity
XPE_RS18100	COG3588	fructose-bisphosphate aldolase
XPE_RS18105	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XPE_RS18120	COG1648	precorrin-2 dehydrogenase activity
XPE_RS18120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XPE_RS18145	COG2198	Histidine kinase
XPE_RS18145	COG0784	Response regulator, receiver
XPE_RS18145	COG2205	protein histidine kinase activity
XPE_RS18165	COG0175	sulfate reduction
XPE_RS18170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XPE_RS18175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPE_RS18180	COG0175	sulfate reduction
XPE_RS18185	COG0529	Catalyzes the synthesis of activated sulfate
XPE_RS18185	COG2895	sulfate adenylyltransferase (ATP) activity
XPE_RS18200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_RS18205	COG0308	aminopeptidase N
XPE_RS18220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPE_RS18235	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_RS18240	COG3250	beta-galactosidase activity
XPE_RS18250	COG1609	Transcriptional regulator
XPE_RS18260	COG1970	mechanosensitive ion channel activity
XPE_RS18285	COG0471	metal ion transport
XPE_RS18285	COG3273	potassium ion transport
XPE_RS18290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XPE_RS18295	COG2022	thiamine diphosphate biosynthetic process
XPE_RS18340	COG0189	ligase activity
XPE_RS18350	COG0745	RESPONSE REGULATOR receiver
XPE_RS18360	COG0237	dephospho-CoA kinase activity
XPE_RS18365	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XPE_RS18420	COG0045	succinate-CoA ligase (ADP-forming) activity
XPE_RS18425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XPE_RS18440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPE_RS18440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XPE_RS18450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_RS18455	COG0564	pseudouridine synthase activity
XPE_RS18470	COG3011	Protein conserved in bacteria
XPE_RS18475	COG0840	transmembrane signaling receptor activity
XPE_RS18495	COG3387	PFAM Glycoside hydrolase 15-related
XPE_RS18500	COG1877	trehalose-phosphatase activity
XPE_RS18505	COG4771	TonB-dependent receptor
XPE_RS18555	COG0542	response to heat
XPE_RS18560	COG4206	TonB-dependent receptor
XPE_RS18580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XPE_RS18590	COG1492	cobalamin metabolic process
XPE_RS18600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XPE_RS18625	COG0019	diaminopimelate decarboxylase activity
XPE_RS18635	COG2814	Major facilitator Superfamily
XPE_RS18640	COG4264	IucA IucC family
XPE_RS18650	COG4772	TonB-dependent receptor
XPE_RS18675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XPE_RS18675	COG4651	solute:proton antiporter activity
XPE_RS18715	COG0488	(ABC) transporter
XPE_RS18735	COG2755	lipolytic protein G-D-S-L family
XPE_RS18735	COG0657	acetylesterase activity
XPE_RS18755	COG0477	Major facilitator Superfamily
XPE_RS18770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XPE_RS18800	COG0217	transcriptional regulatory protein
XPE_RS18805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XPE_RS18810	COG0632	four-way junction helicase activity
XPE_RS18815	COG3158	transport of potassium into the cell
XPE_RS18825	COG2255	four-way junction helicase activity
XPE_RS18830	COG0824	Thioesterase
XPE_RS18840	COG0848	biopolymer transport protein
XPE_RS18850	COG0823	Involved in the tonB-independent uptake of proteins
XPE_RS18855	COG2885	chlorophyll binding
XPE_RS18865	COG0602	queuosine metabolic process
XPE_RS18875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XPE_RS18880	COG3920	Histidine kinase
XPE_RS18900	COG0840	transmembrane signaling receptor activity
XPE_RS18915	COG1187	pseudouridine synthase activity
XPE_RS18945	COG0514	ATP-dependent DNA helicase (RecQ)
XPE_RS18950	COG0783	Belongs to the Dps family
XPE_RS18955	COG1643	Atp-dependent helicase
XPE_RS18965	COG0837	glucose binding
XPE_RS18985	COG0535	radical SAM domain protein
XPE_RS18990	COG0535	radical SAM domain protein
XPE_RS18995	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XPE_RS19000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XPE_RS19010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPE_RS19025	COG1215	transferase activity, transferring glycosyl groups
XPE_RS19030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPE_RS19040	COG1199	ATP-dependent helicase activity
XPE_RS19045	COG1214	PFAM Peptidase M22, glycoprotease
XPE_RS19050	COG1397	ADP-ribosylglycohydrolase
XPE_RS19060	COG1397	ADP-ribosylglycohydrolase
XPE_RS19080	COG0189	ligase activity
XPE_RS19095	COG0835	chemotaxis
XPE_RS19100	COG0840	transmembrane signaling receptor activity
XPE_RS19105	COG0643	Histidine kinase
XPE_RS19105	COG0784	Response regulator, receiver
XPE_RS19105	COG2198	Histidine kinase
XPE_RS19135	COG1595	DNA-templated transcription, initiation
XPE_RS19140	COG2304	oxidoreductase activity
XPE_RS19145	COG1446	asparaginase
XPE_RS19150	COG3142	Participates in the control of copper homeostasis
XPE_RS19195	COG3537	Alpha-1,2-mannosidase
XPE_RS19205	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_RS19220	COG3858	chitin binding
XPE_RS19220	COG1388	LysM domain
XPE_RS19235	COG0837	glucose binding
XPE_RS19240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XPE_RS19250	COG0494	nUDIX hydrolase
XPE_RS19260	COG3956	TIGRFAM MazG family protein
XPE_RS19265	COG1742	UPF0060 membrane protein
XPE_RS19270	COG0330	HflC and HflK could
XPE_RS19280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XPE_RS19285	COG0509	glycine decarboxylation via glycine cleavage system
XPE_RS19310	COG1960	acyl-CoA dehydrogenase activity
XPE_RS19320	COG1309	transcriptional regulator
XPE_RS19335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XPE_RS19340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPE_RS19345	COG0463	Glycosyl transferase, family 2
XPE_RS19350	COG0517	IMP dehydrogenase activity
XPE_RS19350	COG0516	GMP reductase activity
XPE_RS19355	COG2982	Protein involved in outer membrane biogenesis
XPE_RS19360	COG1272	protein, Hemolysin III
XPE_RS19365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XPE_RS19370	COG0739	heme binding
XPE_RS19375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_RS19380	COG0626	cystathionine gamma-synthase activity
XPE_RS19385	COG0527	aspartate kinase activity
XPE_RS19385	COG0460	homoserine dehydrogenase
XPE_RS19400	COG1760	l-serine dehydratase
XPE_RS19420	COG2353	YceI-like domain
XPE_RS19425	COG0784	Response regulator, receiver
XPE_RS19425	COG2205	protein histidine kinase activity
XPE_RS19425	COG2198	Histidine kinase
XPE_RS19445	COG2814	Major facilitator Superfamily
XPE_RS19450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XPE_RS19460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XPE_RS19465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XPE_RS19470	COG0259	pyridoxamine-phosphate oxidase activity
XPE_RS19480	COG1842	Phage shock protein A
XPE_RS19505	COG0754	glutathionylspermidine amidase activity
XPE_RS19510	COG2814	Major facilitator Superfamily
XPE_RS19595	COG0531	amino acid
XPE_RS19600	COG2197	response regulator
XPE_RS19625	COG1113	amino acid transport
XPE_RS19635	COG1271	oxidase subunit
XPE_RS19640	COG1294	oxidase, subunit
XPE_RS19650	COG2239	Acts as a magnesium transporter
XPE_RS19660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XPE_RS19665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPE_RS19675	COG1660	Displays ATPase and GTPase activities
XPE_RS19680	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XPE_RS19685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPE_RS19700	COG1137	ATPase activity
XPE_RS19705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XPE_RS19715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XPE_RS19725	COG0271	Belongs to the BolA IbaG family
XPE_RS19730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XPE_RS19755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XPE_RS19765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XPE_RS19775	COG0628	permease
XPE_RS19785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XPE_RS19805	COG1555	photosystem II stabilization
XPE_RS19820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPE_RS19825	COG1477	protein flavinylation
XPE_RS19850	COG3128	pkhd-type hydroxylase
XPE_RS19855	COG4774	siderophore transport
XPE_RS19860	COG2146	nitrite reductase [NAD(P)H] activity
XPE_RS19865	COG0456	acetyltransferase
XPE_RS19870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XPE_RS19875	COG0719	Fe-S assembly protein
XPE_RS19880	COG0396	ATPase activity
XPE_RS19885	COG0719	Fe-S assembly protein
XPE_RS19890	COG1959	2 iron, 2 sulfur cluster binding
XPE_RS19900	COG0693	protein deglycase activity
XPE_RS19920	COG0739	heme binding
XPE_RS19935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XPE_RS19965	COG0519	Catalyzes the synthesis of GMP from XMP
XPE_RS19975	COG1678	Uncharacterized ACR, COG1678
XPE_RS19980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XPE_RS19985	COG0540	Belongs to the ATCase OTCase family
XPE_RS19990	COG1764	response to oxidative stress
XPE_RS20000	COG0384	phenazine biosynthesis protein PhzF
XPE_RS20005	COG0384	phenazine biosynthesis protein PhzF
XPE_RS20010	COG0527	aspartate kinase activity
XPE_RS20025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XPE_RS20040	COG0142	geranyltranstransferase activity
XPE_RS20045	COG0629	single-stranded DNA binding
XPE_RS20050	COG3706	GGDEF domain
XPE_RS20050	COG2203	Gaf domain
XPE_RS20050	COG4251	negative regulation of phosphorylation
XPE_RS20050	COG5001	Diguanylate cyclase
XPE_RS20055	COG0604	alcohol dehydrogenase
XPE_RS20055	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_RS20055	COG3321	synthase
XPE_RS20060	COG2080	2 iron, 2 sulfur cluster binding
XPE_RS20065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XPE_RS20070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XPE_RS20075	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XPE_RS20115	COG2879	small protein
XPE_RS20120	COG1966	Carbon starvation protein
XPE_RS20125	COG1741	Belongs to the pirin family
XPE_RS20140	COG1741	Belongs to the pirin family
XPE_RS20155	COG1515	deoxyribonuclease V activity
XPE_RS20160	COG0588	phosphoglycerate mutase activity
XPE_RS20170	COG3590	peptidase
XPE_RS20175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_RS20180	COG2201	protein-glutamate methylesterase activity
XPE_RS20185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XPE_RS20190	COG2202	Pas domain
XPE_RS20190	COG2200	EAL domain
XPE_RS20190	COG2199	diguanylate cyclase activity
XPE_RS20195	COG0835	chemotaxis
XPE_RS20200	COG0840	transmembrane signaling receptor activity
XPE_RS20210	COG0643	Histidine kinase
XPE_RS20210	COG2198	Histidine kinase
XPE_RS20220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XPE_RS20230	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XPE_RS20235	COG0745	RESPONSE REGULATOR receiver
XPE_RS20240	COG2205	protein histidine kinase activity
XPE_RS20250	COG4452	Inner membrane protein CreD
XPE_RS20275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPE_RS20280	COG0735	belongs to the Fur family
XPE_RS20295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_RS20305	COG1309	transcriptional regulator
XPE_RS20320	COG2207	Transcriptional regulator
XPE_RS20330	COG0583	DNA-binding transcription factor activity
XPE_RS20335	COG2814	Major facilitator Superfamily
XPE_RS20340	COG0667	Aldo Keto reductase
XPE_RS20455	COG5002	protein histidine kinase activity
XPE_RS20455	COG5001	Diguanylate cyclase
XPE_RS20460	COG1187	pseudouridine synthase activity
XPE_RS20485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XPE_RS20495	COG0475	glutathione-regulated potassium exporter activity
XPE_RS20500	COG5002	protein histidine kinase activity
XPE_RS20500	COG5000	phosphorelay sensor kinase activity
XPE_RS20505	COG0745	RESPONSE REGULATOR receiver
XPE_RS20510	COG1538	Outer membrane efflux protein
XPE_RS20540	COG1132	(ABC) transporter
XPE_RS20585	COG2155	Conserved Protein
XPE_RS20615	COG3118	belongs to the thioredoxin family
XPE_RS20625	COG0495	leucyl-tRNA aminoacylation
XPE_RS20640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XPE_RS20655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XPE_RS20665	COG2968	Membrane
XPE_RS20670	COG0424	maF-like protein
XPE_RS20680	COG3164	Protein of unknown function
XPE_RS20690	COG0312	modulator of DNA gyrase
XPE_RS20695	COG3028	Belongs to the UPF0307 family
XPE_RS20700	COG0312	modulator of DNA gyrase
XPE_RS20710	COG4104	PAAR repeat-containing protein
XPE_RS20715	COG0142	geranyltranstransferase activity
XPE_RS20720	COG1722	exodeoxyribonuclease VII activity
XPE_RS20725	COG0037	tRNA processing
XPE_RS20735	COG1785	Belongs to the alkaline phosphatase family
XPE_RS20740	COG1301	dicarboxylic acid transport
XPE_RS20755	COG0791	NLP P60 protein
XPE_RS20760	COG0791	NLP P60 protein
XPE_RS20765	COG1047	Peptidyl-prolyl cis-trans
XPE_RS20770	COG2311	Membrane
XPE_RS20775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_RS20780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPE_RS20800	COG3590	peptidase
XPE_RS20810	COG3590	peptidase
XPE_RS20830	COG0489	protein tyrosine kinase activity
XPE_RS20840	COG0717	Belongs to the dCTP deaminase family
XPE_RS20865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XPE_RS20870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPE_RS20890	COG0494	nUDIX hydrolase
XPE_RS20895	COG0433	COG0433 Predicted ATPase
XPE_RS20905	COG0688	phosphatidylethanolamine metabolic process
XPE_RS20915	COG2890	protein-(glutamine-N5) methyltransferase activity
XPE_RS20920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XPE_RS20925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XPE_RS20930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XPE_RS20945	COG0101	tRNA pseudouridine synthase activity
XPE_RS20950	COG0135	phosphoribosylanthranilate isomerase activity
XPE_RS20960	COG0133	tryptophan synthase activity
XPE_RS20970	COG0159	tryptophan synthase activity
XPE_RS20975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XPE_RS20980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XPE_RS21015	COG4221	oxidoreductase activity
XPE_RS21020	COG0149	triose-phosphate isomerase activity
XPE_RS21035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_RS21040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_RS21045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_RS21050	COG0649	NAD binding
XPE_RS21055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XPE_RS21060	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XPE_RS21065	COG1034	ATP synthesis coupled electron transport
XPE_RS21070	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XPE_RS21075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_RS21100	COG1007	ATP synthesis coupled electron transport
XPE_RS21110	COG0779	Required for maturation of 30S ribosomal subunits
XPE_RS21115	COG0195	Participates in both transcription termination and antitermination
XPE_RS21120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XPE_RS21125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XPE_RS21130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XPE_RS21135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XPE_RS21140	COG1185	polyribonucleotide nucleotidyltransferase activity
XPE_RS21175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XPE_RS21185	COG2095	MarC family integral membrane protein
XPE_RS21200	COG1611	Belongs to the LOG family
XPE_RS21205	COG3275	phosphorelay sensor kinase activity
XPE_RS21250	COG0556	nucleotide-excision repair
XPE_RS21270	COG3505	Type IV secretory pathway VirD4
XPE_RS21290	COG2948	multi-organism process
XPE_RS21310	COG3702	type iv secretory pathway
XPE_RS21370	COG0366	Alpha amylase catalytic
XPE_RS21385	COG1082	Xylose isomerase domain protein TIM barrel
XPE_RS21410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XPE_RS21415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XPE_RS21430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XPE_RS21435	COG0072	phenylalanine-tRNA ligase activity
XPE_RS21435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPE_RS21485	COG0438	transferase activity, transferring glycosyl groups
XPE_RS21490	COG0438	transferase activity, transferring glycosyl groups
XPE_RS21500	COG0438	transferase activity, transferring glycosyl groups
XPE_RS21525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_RS21530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPE_RS21535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPE_RS21555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XPE_RS21565	COG1960	acyl-CoA dehydrogenase activity
XPE_RS21575	COG3040	lipid binding
XPE_RS21590	COG0322	excinuclease ABC activity
XPE_RS21605	COG4191	Histidine kinase
XPE_RS21605	COG0784	Response regulator, receiver
XPE_RS21615	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XPE_RS21620	COG1194	a g-specific adenine glycosylase
XPE_RS21630	COG0552	protein localization to endoplasmic reticulum
XPE_RS21640	COG3938	Belongs to the proline racemase family
XPE_RS21645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_RS21660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XPE_RS21670	COG0006	proline dipeptidase activity
XPE_RS21685	COG0531	amino acid
XPE_RS21755	COG0326	Molecular chaperone. Has ATPase activity
XPE_RS21760	COG0742	ribosomal rna small subunit methyltransferase
XPE_RS21765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XPE_RS21780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XPE_RS21785	COG0405	Gamma-glutamyltransferase
XPE_RS21790	COG3291	Pkd domain containing protein
XPE_RS21795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate