locus-tag	class	description
AC610_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC610_RS00025	COG0187	DNA topoisomerase II activity
AC610_RS00035	COG0501	Belongs to the peptidase M48B family
AC610_RS00090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC610_RS00100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC610_RS00145	COG0793	Belongs to the peptidase S41A family
AC610_RS00150	COG4942	peptidase
AC610_RS00160	COG2234	aminopeptidase activity
AC610_RS00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC610_RS00175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC610_RS00185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC610_RS00195	COG1064	alcohol dehydrogenase
AC610_RS00210	COG0493	'glutamate synthase
AC610_RS00215	COG0067	glutamate synthase
AC610_RS00215	COG0069	glutamate synthase activity
AC610_RS00215	COG0070	glutamate synthase
AC610_RS00305	COG1205	dead DEAH box helicase
AC610_RS00305	COG1111	helicase
AC610_RS00310	COG1272	protein, Hemolysin III
AC610_RS00330	COG0300	oxidoreductase activity
AC610_RS00335	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS00375	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC610_RS00390	COG3039	Transposase
AC610_RS00405	COG3039	Transposase
AC610_RS00425	COG3237	CsbD-like
AC610_RS00470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC610_RS00480	COG0477	Major facilitator Superfamily
AC610_RS00525	COG0714	Associated with various cellular activities
AC610_RS00570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC610_RS00580	COG4772	TonB-dependent receptor
AC610_RS00610	COG1304	FMN binding
AC610_RS00615	COG1755	Isoprenylcysteine carboxyl methyltransferase
AC610_RS00620	COG4585	Histidine kinase
AC610_RS00625	COG2197	response regulator
AC610_RS00650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC610_RS00655	COG3039	Transposase
AC610_RS00660	COG3039	Transposase
AC610_RS00675	COG0366	Alpha amylase catalytic
AC610_RS00680	COG0366	Alpha amylase catalytic
AC610_RS00685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC610_RS00705	COG2755	lipolytic protein G-D-S-L family
AC610_RS00705	COG0657	acetylesterase activity
AC610_RS00715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC610_RS00730	COG3507	Belongs to the glycosyl hydrolase 43 family
AC610_RS00735	COG1609	Transcriptional regulator
AC610_RS00740	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC610_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS00755	COG2755	lipolytic protein G-D-S-L family
AC610_RS00765	COG3186	Phenylalanine-4-hydroxylase
AC610_RS00770	COG1522	sequence-specific DNA binding
AC610_RS00780	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC610_RS00790	COG1119	ATPase activity
AC610_RS00805	COG0517	IMP dehydrogenase activity
AC610_RS00805	COG1125	glycine betaine transport
AC610_RS00820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC610_RS00855	COG0489	protein tyrosine kinase activity
AC610_RS00860	COG2062	phosphohistidine phosphatase, SixA
AC610_RS00870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC610_RS00910	COG1968	undecaprenyl-diphosphatase activity
AC610_RS00920	COG0174	glutamine synthetase
AC610_RS00925	COG0347	Belongs to the P(II) protein family
AC610_RS00930	COG0004	ammonium transporteR
AC610_RS00935	COG3852	Histidine kinase
AC610_RS00940	COG2204	response regulator
AC610_RS00945	COG2032	superoxide dismutase activity
AC610_RS00950	COG2032	superoxide dismutase activity
AC610_RS00965	COG0183	Belongs to the thiolase family
AC610_RS01000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC610_RS01005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC610_RS01010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC610_RS01040	COG2205	protein histidine kinase activity
AC610_RS01065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC610_RS01080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC610_RS01085	COG3177	Filamentation induced by cAMP protein fic
AC610_RS01090	COG0596	Alpha beta hydrolase
AC610_RS01095	COG0727	PFAM Uncharacterised protein family (UPF0153)
AC610_RS01100	COG0318	PFAM AMP-dependent synthetase and ligase
AC610_RS01105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC610_RS01120	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC610_RS01135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC610_RS01145	COG0564	pseudouridine synthase activity
AC610_RS01170	COG1446	asparaginase
AC610_RS01175	COG0339	signal peptide processing
AC610_RS01210	COG0475	glutathione-regulated potassium exporter activity
AC610_RS01225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC610_RS01230	COG2224	Isocitrate lyase
AC610_RS01250	COG3039	Transposase
AC610_RS01270	COG4770	biotin carboxylase activity
AC610_RS01275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC610_RS01280	COG1960	acyl-CoA dehydrogenase activity
AC610_RS01345	COG0697	spore germination
AC610_RS01355	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC610_RS01360	COG1846	Transcriptional regulator
AC610_RS01365	COG1764	response to oxidative stress
AC610_RS01385	COG2130	NADP-dependent
AC610_RS01400	COG1187	pseudouridine synthase activity
AC610_RS01410	COG1643	Atp-dependent helicase
AC610_RS01425	COG4807	Protein conserved in bacteria
AC610_RS01435	COG2072	flavoprotein involved in K transport
AC610_RS01455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC610_RS01465	COG0583	DNA-binding transcription factor activity
AC610_RS01505	COG2252	PERMEase
AC610_RS01530	COG0084	hydrolase, TatD family'
AC610_RS01545	COG0583	DNA-binding transcription factor activity
AC610_RS01550	COG2814	Major facilitator Superfamily
AC610_RS01565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC610_RS01570	COG1902	pentaerythritol trinitrate reductase activity
AC610_RS01590	COG0745	RESPONSE REGULATOR receiver
AC610_RS01595	COG2205	protein histidine kinase activity
AC610_RS01600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC610_RS01625	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC610_RS01630	COG0583	DNA-binding transcription factor activity
AC610_RS01670	COG0702	epimerase
AC610_RS01675	COG1733	regulation of RNA biosynthetic process
AC610_RS01695	COG3328	transposase activity
AC610_RS01740	COG0129	dihydroxy-acid dehydratase activity
AC610_RS01755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AC610_RS01810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC610_RS01815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AC610_RS01840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC610_RS01855	COG3485	protocatechuate 3,4-dioxygenase
AC610_RS01860	COG3485	protocatechuate 3,4-dioxygenase
AC610_RS01870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC610_RS01875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC610_RS01885	COG1414	Transcriptional regulator
AC610_RS01895	COG0657	acetylesterase activity
AC610_RS01905	COG0445	tRNA wobble uridine modification
AC610_RS01915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC610_RS01950	COG2267	carboxylic ester hydrolase activity
AC610_RS01960	COG0156	8-amino-7-oxononanoate synthase activity
AC610_RS01965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC610_RS01970	COG1040	competence protein
AC610_RS01975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC610_RS02000	COG3039	Transposase
AC610_RS02065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC610_RS02140	COG1511	domain protein
AC610_RS02140	COG3264	Mechanosensitive ion channel
AC610_RS02145	COG1368	sulfuric ester hydrolase activity
AC610_RS02150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC610_RS02155	COG2354	Protein conserved in bacteria
AC610_RS02165	COG0297	glycogen (starch) synthase activity
AC610_RS02170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC610_RS02175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC610_RS02200	COG0702	epimerase
AC610_RS02230	COG3328	transposase activity
AC610_RS02240	COG3039	Transposase
AC610_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS02290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC610_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS02305	COG0513	Belongs to the DEAD box helicase family
AC610_RS02310	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC610_RS02325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC610_RS02335	COG3483	tryptophan 2,3-dioxygenase activity
AC610_RS02340	COG3104	oligopeptide transport
AC610_RS02360	COG2852	Protein conserved in bacteria
AC610_RS02365	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AC610_RS02385	COG1320	monovalent cation:proton antiporter activity
AC610_RS02390	COG2212	antiporter activity
AC610_RS02400	COG0651	ATP synthesis coupled electron transport
AC610_RS02405	COG1006	Multisubunit Na H antiporter MnhC subunit
AC610_RS02410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC610_RS02410	COG2111	Na H antiporter
AC610_RS02430	COG3179	chitinase
AC610_RS02450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC610_RS02455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC610_RS02475	COG1597	lipid kinase activity
AC610_RS02500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC610_RS02505	COG0134	indole-3-glycerol-phosphate synthase activity
AC610_RS02515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC610_RS02520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AC610_RS02530	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC610_RS02540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC610_RS02555	COG1051	belongs to the nudix hydrolase family
AC610_RS02595	COG0316	Belongs to the HesB IscA family
AC610_RS02610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC610_RS02625	COG2814	Major facilitator Superfamily
AC610_RS02635	COG2814	Major facilitator Superfamily
AC610_RS02640	COG1289	transmembrane transporter activity
AC610_RS02650	COG0151	Belongs to the GarS family
AC610_RS02660	COG0138	bifunctional purine biosynthesis protein purh
AC610_RS02665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC610_RS02670	COG2267	carboxylic ester hydrolase activity
AC610_RS02675	COG0671	phosphoesterase, PA-phosphatase related
AC610_RS02675	COG2453	phosphatase
AC610_RS02700	COG4589	Belongs to the CDS family
AC610_RS02705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC610_RS02730	COG2264	protein methyltransferase activity
AC610_RS02750	COG0439	Biotin carboxylase
AC610_RS02760	COG0511	ligase activity, forming carbon-carbon bonds
AC610_RS02765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC610_RS02775	COG1324	tolerance protein
AC610_RS02795	COG0459	protein refolding
AC610_RS02810	COG3550	peptidyl-serine autophosphorylation
AC610_RS02815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC610_RS02830	COG3386	PFAM SMP-30 Gluconolaconase
AC610_RS02840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC610_RS02845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC610_RS02865	COG3039	Transposase
AC610_RS02885	COG0778	Nitroreductase
AC610_RS02890	COG2353	YceI-like domain
AC610_RS02925	COG3052	prosthetic group binding
AC610_RS02950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC610_RS02960	COG1802	Transcriptional regulator
AC610_RS03015	COG3328	transposase activity
AC610_RS03030	COG4221	oxidoreductase activity
AC610_RS03060	COG4221	oxidoreductase activity
AC610_RS03070	COG0435	Glutathione S-transferase
AC610_RS03150	COG1959	2 iron, 2 sulfur cluster binding
AC610_RS03175	COG0697	spore germination
AC610_RS03180	COG4305	rare lipoprotein A
AC610_RS03185	COG5297	Belongs to the glycosyl hydrolase family 6
AC610_RS03195	COG1113	amino acid transport
AC610_RS03205	COG0598	Magnesium transport protein CorA
AC610_RS03250	COG3447	MASE1 domain protein
AC610_RS03250	COG5001	Diguanylate cyclase
AC610_RS03250	COG5002	protein histidine kinase activity
AC610_RS03265	COG0784	Response regulator, receiver
AC610_RS03265	COG2205	protein histidine kinase activity
AC610_RS03330	COG2943	transferase activity, transferring hexosyl groups
AC610_RS03340	COG3275	phosphorelay sensor kinase activity
AC610_RS03350	COG0181	hydroxymethylbilane synthase activity
AC610_RS03390	COG1505	serine-type exopeptidase activity
AC610_RS03400	COG0436	Aminotransferase
AC610_RS03410	COG2832	Protein of unknown function (DUF454)
AC610_RS03420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC610_RS03430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC610_RS03435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC610_RS03440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC610_RS03470	COG2226	methyltransferase
AC610_RS03475	COG5001	Diguanylate cyclase
AC610_RS03475	COG3300	MHYT domain
AC610_RS03480	COG0308	aminopeptidase N
AC610_RS03530	COG3284	Transcriptional regulator
AC610_RS03545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC610_RS03550	COG1077	Cell shape determining protein MreB Mrl
AC610_RS03555	COG1792	Involved in formation and maintenance of cell shape
AC610_RS03570	COG0772	Belongs to the SEDS family
AC610_RS03585	COG3039	Transposase
AC610_RS03615	COG2951	lytic endotransglycosylase activity
AC610_RS03620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AC610_RS03625	COG1686	Belongs to the peptidase S11 family
AC610_RS03635	COG2921	Belongs to the UPF0250 family
AC610_RS03640	COG0321	lipoyl(octanoyl) transferase activity
AC610_RS03645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC610_RS03670	COG1051	belongs to the nudix hydrolase family
AC610_RS03670	COG1056	cytidyltransferase-related domain
AC610_RS03705	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC610_RS03710	COG0673	inositol 2-dehydrogenase activity
AC610_RS03715	COG2823	Periplasmic or secreted lipoprotein
AC610_RS03720	COG4251	negative regulation of phosphorylation
AC610_RS03725	COG0784	Response regulator, receiver
AC610_RS03730	COG4191	Histidine kinase
AC610_RS03735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC610_RS03790	COG1459	type II secretion system
AC610_RS03835	COG2188	Transcriptional regulator
AC610_RS03845	COG1609	Transcriptional regulator
AC610_RS03850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC610_RS03855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC610_RS03865	COG0617	tRNA 3'-terminal CCA addition
AC610_RS03885	COG0525	valine-tRNA ligase activity
AC610_RS03900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC610_RS03910	COG0795	lipopolysaccharide-transporting ATPase activity
AC610_RS03925	COG4974	Belongs to the 'phage' integrase family
AC610_RS03940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC610_RS03950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC610_RS03950	COG0047	phosphoribosylformylglycinamidine synthase activity
AC610_RS03955	COG5295	Hep Hag repeat protein
AC610_RS03960	COG1404	Belongs to the peptidase S8 family
AC610_RS03965	COG5295	Hep Hag repeat protein
AC610_RS03970	COG1404	Belongs to the peptidase S8 family
AC610_RS03975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC610_RS03985	COG1459	type II secretion system
AC610_RS03990	COG2165	general secretion pathway protein
AC610_RS03995	COG4970	Tfp pilus assembly protein FimT
AC610_RS04000	COG2165	general secretion pathway protein
AC610_RS04005	COG4795	General secretion pathway protein
AC610_RS04010	COG3156	type II secretion system protein K
AC610_RS04015	COG3166	PFAM Fimbrial assembly family protein
AC610_RS04030	COG1450	Type ii and iii secretion system protein
AC610_RS04040	COG2188	Transcriptional regulator
AC610_RS04120	COG1215	transferase activity, transferring glycosyl groups
AC610_RS04125	COG1215	transferase activity, transferring glycosyl groups
AC610_RS04130	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AC610_RS04155	COG0242	peptide deformylase activity
AC610_RS04160	COG0488	(ABC) transporter
AC610_RS04170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC610_RS04175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC610_RS04185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC610_RS04185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC610_RS04195	COG3328	transposase activity
AC610_RS04210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC610_RS04215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC610_RS04220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AC610_RS04240	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AC610_RS04245	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AC610_RS04255	COG2205	protein histidine kinase activity
AC610_RS04260	COG0745	RESPONSE REGULATOR receiver
AC610_RS04270	COG0277	FAD linked oxidase domain protein
AC610_RS04275	COG1988	membrane-bound metal-dependent
AC610_RS04280	COG0792	nuclease activity
AC610_RS04325	COG3116	cell division
AC610_RS04335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC610_RS04340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC610_RS04345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC610_RS04355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC610_RS04360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC610_RS04365	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC610_RS04370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC610_RS04385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC610_RS04395	COG0739	heme binding
AC610_RS04400	COG0653	protein targeting
AC610_RS04405	COG0494	nUDIX hydrolase
AC610_RS04415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC610_RS04425	COG0604	alcohol dehydrogenase
AC610_RS04425	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS04425	COG3321	synthase
AC610_RS04440	COG0366	Alpha amylase catalytic
AC610_RS04475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AC610_RS04480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC610_RS04490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC610_RS04530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC610_RS04540	COG4106	trans-aconitate 2-methyltransferase activity
AC610_RS04545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC610_RS04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC610_RS04565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AC610_RS04570	COG0667	Aldo Keto reductase
AC610_RS04580	COG4771	TonB-dependent receptor
AC610_RS04600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC610_RS04605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AC610_RS04615	COG2175	clavaminate synthase activity
AC610_RS04625	COG4181	ATPase activity
AC610_RS04640	COG0642	Histidine kinase
AC610_RS04650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC610_RS04660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AC610_RS04670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC610_RS04675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC610_RS04690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC610_RS04695	COG2967	ApaG domain
AC610_RS04700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC610_RS04705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC610_RS04710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC610_RS04715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC610_RS04730	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC610_RS04735	COG2096	Adenosyltransferase
AC610_RS04750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC610_RS04755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC610_RS04785	COG3384	dioxygenase
AC610_RS04790	COG0583	DNA-binding transcription factor activity
AC610_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
AC610_RS04805	COG1024	Enoyl-CoA hydratase
AC610_RS04825	COG3386	PFAM SMP-30 Gluconolaconase
AC610_RS04835	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC610_RS04855	COG0697	spore germination
AC610_RS04865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC610_RS04890	COG2197	response regulator
AC610_RS04900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC610_RS04915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC610_RS04920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC610_RS04930	COG0583	DNA-binding transcription factor activity
AC610_RS04935	COG3634	alkyl hydroperoxide reductase activity
AC610_RS04945	COG2890	protein-(glutamine-N5) methyltransferase activity
AC610_RS04965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC610_RS04965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC610_RS05005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC610_RS05020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC610_RS05025	COG1404	Belongs to the peptidase S8 family
AC610_RS05030	COG1404	Belongs to the peptidase S8 family
AC610_RS05035	COG1404	Belongs to the peptidase S8 family
AC610_RS05040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC610_RS05065	COG1295	ribonuclease BN
AC610_RS05070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC610_RS05075	COG1254	Belongs to the acylphosphatase family
AC610_RS05090	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC610_RS05100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC610_RS05105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC610_RS05115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC610_RS05120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC610_RS05130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC610_RS05135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC610_RS05140	COG0193	aminoacyl-tRNA hydrolase activity
AC610_RS05145	COG0012	GTP binding
AC610_RS05165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC610_RS05180	COG0250	Participates in transcription elongation, termination and antitermination
AC610_RS05185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC610_RS05190	COG0081	regulation of translation
AC610_RS05195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC610_RS05205	COG0085	RNA polymerase activity
AC610_RS05210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC610_RS05215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC610_RS05220	COG0049	tRNA binding
AC610_RS05225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC610_RS05230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC610_RS05245	COG3328	transposase activity
AC610_RS05250	COG0051	transcription antitermination factor activity, RNA binding
AC610_RS05255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC610_RS05260	COG0088	Forms part of the polypeptide exit tunnel
AC610_RS05265	COG0089	rRNA binding
AC610_RS05270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC610_RS05275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC610_RS05285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC610_RS05290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC610_RS05295	COG0255	Belongs to the universal ribosomal protein uL29 family
AC610_RS05300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC610_RS05310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC610_RS05315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC610_RS05325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC610_RS05330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC610_RS05335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC610_RS05345	COG1841	ribosomal large subunit assembly
AC610_RS05350	COG0200	Binds to the 23S rRNA
AC610_RS05355	COG0201	protein transport
AC610_RS05380	COG0203	ribosomal protein L17
AC610_RS05385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC610_RS05405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC610_RS05415	COG0154	amidase activity
AC610_RS05425	COG1217	gtp-binding protein TYPA
AC610_RS05430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC610_RS05435	COG0039	L-malate dehydrogenase activity
AC610_RS05440	COG0625	glutathione transferase activity
AC610_RS05460	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC610_RS05460	COG1902	pentaerythritol trinitrate reductase activity
AC610_RS05465	COG0604	alcohol dehydrogenase
AC610_RS05475	COG3328	transposase activity
AC610_RS05480	COG3039	Transposase
AC610_RS05485	COG2885	chlorophyll binding
AC610_RS05505	COG0156	8-amino-7-oxononanoate synthase activity
AC610_RS05510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC610_RS05515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AC610_RS05520	COG4208	sulfate ABC transporter
AC610_RS05525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC610_RS05535	COG3328	transposase activity
AC610_RS05560	COG0406	alpha-ribazole phosphatase activity
AC610_RS05570	COG0285	dihydrofolate synthase activity
AC610_RS05590	COG2833	Protein of unknown function (DUF455)
AC610_RS05610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC610_RS05615	COG0671	phosphoesterase, PA-phosphatase related
AC610_RS05620	COG0438	transferase activity, transferring glycosyl groups
AC610_RS05630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC610_RS05645	COG4783	chaperone-mediated protein folding
AC610_RS05660	COG0473	3-isopropylmalate dehydrogenase activity
AC610_RS05700	COG3328	transposase activity
AC610_RS05715	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC610_RS05725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC610_RS05755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC610_RS05765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC610_RS05775	COG0328	RNA-DNA hybrid ribonuclease activity
AC610_RS05780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC610_RS05785	COG0631	protein serine/threonine phosphatase activity
AC610_RS05810	COG0859	PFAM glycosyl transferase family 9
AC610_RS05815	COG3642	lipopolysaccharide core region biosynthetic process
AC610_RS05820	COG1234	tRNA 3'-trailer cleavage
AC610_RS05825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC610_RS05835	COG0315	cyclic pyranopterin monophosphate synthase activity
AC610_RS05840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC610_RS05845	COG0314	molybdopterin synthase activity
AC610_RS05865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC610_RS05870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC610_RS05875	COG0537	adenosine 5'-monophosphoramidase activity
AC610_RS05895	COG0714	Associated with various cellular activities
AC610_RS05910	COG0424	maF-like protein
AC610_RS05915	COG1399	metal-binding, possibly nucleic acid-binding protein
AC610_RS05920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AC610_RS05925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC610_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS05955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AC610_RS05960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC610_RS05995	COG3829	transcription factor binding
AC610_RS06045	COG2373	Large extracellular alpha-helical protein
AC610_RS06070	COG3852	Histidine kinase
AC610_RS06075	COG4953	penicillin-binding protein 1C
AC610_RS06085	COG0678	peroxiredoxin activity
AC610_RS06105	COG0330	HflC and HflK could
AC610_RS06110	COG0330	HflC and HflK could
AC610_RS06120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC610_RS06125	COG0308	aminopeptidase N
AC610_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS06140	COG1309	transcriptional regulator
AC610_RS06200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC610_RS06210	COG3387	PFAM Glycoside hydrolase 15-related
AC610_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS06225	COG3537	Alpha-1,2-mannosidase
AC610_RS06250	COG0492	ferredoxin-NADP+ reductase activity
AC610_RS06280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC610_RS06285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC610_RS06290	COG2080	2 iron, 2 sulfur cluster binding
AC610_RS06325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC610_RS06340	COG0587	DNA-directed DNA polymerase activity
AC610_RS06360	COG1297	OPT oligopeptide transporter protein
AC610_RS06395	COG0823	Involved in the tonB-independent uptake of proteins
AC610_RS06395	COG1506	peptidase
AC610_RS06435	COG1917	Cupin 2, conserved barrel domain protein
AC610_RS06435	COG2207	Transcriptional regulator
AC610_RS06450	COG3328	transposase activity
AC610_RS06465	COG0753	catalase activity
AC610_RS06470	COG0656	L-ascorbic acid biosynthetic process
AC610_RS06480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC610_RS06480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC610_RS06505	COG2814	Major facilitator Superfamily
AC610_RS06530	COG2963	transposase activity
AC610_RS06540	COG2194	sulfuric ester hydrolase activity
AC610_RS06555	COG0745	RESPONSE REGULATOR receiver
AC610_RS06560	COG0642	Histidine kinase
AC610_RS06570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC610_RS06575	COG2894	cell division
AC610_RS06580	COG0850	regulation of cytokinetic process
AC610_RS06595	COG4585	Histidine kinase
AC610_RS06600	COG2197	response regulator
AC610_RS06615	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC610_RS06645	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC610_RS06655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC610_RS06670	COG1595	DNA-templated transcription, initiation
AC610_RS06680	COG1946	Acyl-CoA thioesterase
AC610_RS06695	COG0824	Thioesterase
AC610_RS06700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC610_RS06705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC610_RS06710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC610_RS06715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC610_RS06720	COG0268	Binds directly to 16S ribosomal RNA
AC610_RS06730	COG0196	riboflavin kinase activity
AC610_RS06735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC610_RS06740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC610_RS06745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC610_RS06865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC610_RS06865	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AC610_RS06900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC610_RS06905	COG1845	cytochrome c oxidase, subunit III
AC610_RS06910	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AC610_RS06925	COG3152	Membrane
AC610_RS06935	COG2207	Transcriptional regulator
AC610_RS06940	COG0326	Molecular chaperone. Has ATPase activity
AC610_RS06950	COG1366	Belongs to the anti-sigma-factor antagonist family
AC610_RS06955	COG1366	Belongs to the anti-sigma-factor antagonist family
AC610_RS06985	COG4771	TonB-dependent receptor
AC610_RS06995	COG5507	3-demethylubiquinone-9 3-methyltransferase
AC610_RS07000	COG2205	protein histidine kinase activity
AC610_RS07010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC610_RS07015	COG4999	Histidine kinase
AC610_RS07015	COG3850	Histidine kinase
AC610_RS07015	COG3437	response regulator, receiver
AC610_RS07015	COG2205	protein histidine kinase activity
AC610_RS07020	COG4191	Histidine kinase
AC610_RS07020	COG0784	Response regulator, receiver
AC610_RS07045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC610_RS07055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC610_RS07060	COG0228	four-way junction DNA binding
AC610_RS07065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC610_RS07070	COG0336	Belongs to the RNA methyltransferase TrmD family
AC610_RS07075	COG0335	large ribosomal subunit rRNA binding
AC610_RS07080	COG0534	Mate efflux family protein
AC610_RS07105	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC610_RS07120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC610_RS07160	COG3250	beta-galactosidase activity
AC610_RS07165	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AC610_RS07185	COG1960	acyl-CoA dehydrogenase activity
AC610_RS07215	COG0457	Tetratricopeptide repeat
AC610_RS07225	COG0457	Tetratricopeptide repeat
AC610_RS07235	COG1024	Enoyl-CoA hydratase
AC610_RS07235	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC610_RS07250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC610_RS07260	COG0481	GTPase activity
AC610_RS07275	COG0571	ribonuclease III activity
AC610_RS07280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC610_RS07285	COG1381	Involved in DNA repair and RecF pathway recombination
AC610_RS07295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC610_RS07300	COG2954	triphosphatase activity
AC610_RS07305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC610_RS07310	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC610_RS07315	COG3046	protein related to deoxyribodipyrimidine photolyase
AC610_RS07320	COG1472	Belongs to the glycosyl hydrolase 3 family
AC610_RS07325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AC610_RS07330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AC610_RS07335	COG1278	Cold shock
AC610_RS07340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC610_RS07350	COG1201	RNA secondary structure unwinding
AC610_RS07355	COG1793	dna ligase
AC610_RS07365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC610_RS07365	COG1793	dna ligase
AC610_RS07405	COG0183	Belongs to the thiolase family
AC610_RS07425	COG1451	nucleotide metabolic process
AC610_RS07430	COG5487	UPF0391 membrane protein
AC610_RS07440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC610_RS07460	COG1077	Cell shape determining protein MreB Mrl
AC610_RS07465	COG1047	Peptidyl-prolyl cis-trans
AC610_RS07475	COG2824	Alkylphosphonate utilization operon protein PhnA
AC610_RS07485	COG1902	pentaerythritol trinitrate reductase activity
AC610_RS07490	COG2814	Major facilitator Superfamily
AC610_RS07525	COG0392	lysyltransferase activity
AC610_RS07525	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AC610_RS07535	COG0251	oxidation-reduction process
AC610_RS07540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC610_RS07555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC610_RS07580	COG1595	DNA-templated transcription, initiation
AC610_RS07595	COG2878	Part of a membrane complex involved in electron transport
AC610_RS07610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC610_RS07610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC610_RS07635	COG0346	lactoylglutathione lyase activity
AC610_RS07650	COG0833	amino acid
AC610_RS07655	COG2040	homocysteine
AC610_RS07665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC610_RS07685	COG1695	Transcriptional regulator
AC610_RS07705	COG1981	membrane
AC610_RS07720	COG0825	malonyl-CoA metabolic process
AC610_RS07735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC610_RS07740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC610_RS07745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC610_RS07750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC610_RS07765	COG0750	zinc metalloprotease
AC610_RS07770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC610_RS07775	COG0575	Belongs to the CDS family
AC610_RS07780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC610_RS07785	COG0233	cytoplasmic translational termination
AC610_RS07790	COG0528	UMP kinase activity
AC610_RS07800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC610_RS07805	COG0052	Belongs to the universal ribosomal protein uS2 family
AC610_RS07845	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC610_RS07855	COG1393	Belongs to the ArsC family
AC610_RS07860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC610_RS07865	COG0367	asparagine synthase
AC610_RS07875	COG4774	siderophore transport
AC610_RS07935	COG3328	transposase activity
AC610_RS07970	COG1566	PFAM secretion protein HlyD family protein
AC610_RS07975	COG2814	Major facilitator Superfamily
AC610_RS08005	COG3104	oligopeptide transport
AC610_RS08035	COG0339	signal peptide processing
AC610_RS08040	COG0386	Belongs to the glutathione peroxidase family
AC610_RS08100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC610_RS08105	COG0084	hydrolase, TatD family'
AC610_RS08120	COG1960	acyl-CoA dehydrogenase activity
AC610_RS08140	COG0367	asparagine synthase
AC610_RS08150	COG0305	Participates in initiation and elongation during chromosome replication
AC610_RS08155	COG0415	Belongs to the DNA photolyase family
AC610_RS08175	COG0583	DNA-binding transcription factor activity
AC610_RS08220	COG3706	GGDEF domain
AC610_RS08240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC610_RS08255	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC610_RS08265	COG0497	DNA recombination
AC610_RS08270	COG1420	regulation of RNA biosynthetic process
AC610_RS08275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC610_RS08280	COG0443	Heat shock 70 kDa protein
AC610_RS08285	COG0484	heat shock protein binding
AC610_RS08290	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AC610_RS08320	COG0583	DNA-binding transcription factor activity
AC610_RS08330	COG1132	(ABC) transporter
AC610_RS08365	COG2850	peptidyl-arginine hydroxylation
AC610_RS08385	COG1253	flavin adenine dinucleotide binding
AC610_RS08420	COG1131	(ABC) transporter
AC610_RS08425	COG1725	Transcriptional regulator
AC610_RS08435	COG0386	Belongs to the glutathione peroxidase family
AC610_RS08445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AC610_RS08455	COG2900	Belongs to the SlyX family
AC610_RS08485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC610_RS08495	COG1410	methionine synthase
AC610_RS08495	COG0646	methionine synthase
AC610_RS08500	COG0646	methionine synthase
AC610_RS08500	COG1410	methionine synthase
AC610_RS08505	COG2226	methyltransferase
AC610_RS08510	COG1960	acyl-CoA dehydrogenase activity
AC610_RS08515	COG1960	acyl-CoA dehydrogenase activity
AC610_RS08530	COG0557	exoribonuclease II activity
AC610_RS08540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC610_RS08555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC610_RS08565	COG0704	Plays a role in the regulation of phosphate uptake
AC610_RS08570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC610_RS08575	COG0581	inorganic phosphate transmembrane transporter activity
AC610_RS08580	COG0573	inorganic phosphate transmembrane transporter activity
AC610_RS08585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC610_RS08610	COG0659	secondary active sulfate transmembrane transporter activity
AC610_RS08615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC610_RS08625	COG1024	Enoyl-CoA hydratase
AC610_RS08635	COG0494	nUDIX hydrolase
AC610_RS08670	COG0488	(ABC) transporter
AC610_RS08680	COG0116	Belongs to the methyltransferase superfamily
AC610_RS08680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC610_RS08685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC610_RS08705	COG2925	Exonuclease
AC610_RS08715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC610_RS08720	COG3844	kynureninase activity
AC610_RS08730	COG0662	Cupin 2, conserved barrel domain protein
AC610_RS08735	COG0288	reversible hydration of carbon dioxide
AC610_RS08815	COG0017	Asparaginyl-tRNA synthetase
AC610_RS08825	COG0316	Belongs to the HesB IscA family
AC610_RS08830	COG0360	Binds together with S18 to 16S ribosomal RNA
AC610_RS08835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC610_RS08840	COG0359	binds to the 23S rRNA
AC610_RS08850	COG3115	cell septum assembly
AC610_RS08860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC610_RS08865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC610_RS08870	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AC610_RS08885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC610_RS08895	COG4993	Dehydrogenase
AC610_RS08905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC610_RS08915	COG2986	histidine ammonia-lyase
AC610_RS08920	COG1228	amidohydrolase
AC610_RS08960	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC610_RS08965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC610_RS08970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC610_RS08975	COG0077	Prephenate dehydratase
AC610_RS08975	COG1605	Chorismate mutase
AC610_RS08980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC610_RS08995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC610_RS09000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC610_RS09005	COG0583	DNA-binding transcription factor activity
AC610_RS09065	COG0784	Response regulator, receiver
AC610_RS09065	COG4191	Histidine kinase
AC610_RS09075	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AC610_RS09095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC610_RS09105	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC610_RS09115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC610_RS09130	COG1595	DNA-templated transcription, initiation
AC610_RS09185	COG2244	polysaccharide biosynthetic process
AC610_RS09215	COG2264	protein methyltransferase activity
AC610_RS09240	COG1136	(ABC) transporter
AC610_RS09250	COG0477	Major facilitator Superfamily
AC610_RS09255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC610_RS09270	COG1253	flavin adenine dinucleotide binding
AC610_RS09285	COG0306	phosphate transporter
AC610_RS09310	COG0504	CTP synthase activity
AC610_RS09315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AC610_RS09325	COG0148	phosphopyruvate hydratase activity
AC610_RS09330	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC610_RS09340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC610_RS09345	COG0585	pseudouridine synthase activity
AC610_RS09350	COG2840	Smr protein MutS2
AC610_RS09355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC610_RS09360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC610_RS09365	COG1238	metal cluster binding
AC610_RS09375	COG3737	Protein of unknown function (DUF498/DUF598)
AC610_RS09380	COG1534	Rna-binding protein
AC610_RS09385	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC610_RS09395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC610_RS09400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC610_RS09410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC610_RS09415	COG1546	Belongs to the CinA family
AC610_RS09425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC610_RS09430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC610_RS09440	COG2137	regulation of response to DNA damage stimulus
AC610_RS09445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC610_RS09450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AC610_RS09470	COG0583	DNA-binding transcription factor activity
AC610_RS09495	COG0351	phosphomethylpyrimidine kinase
AC610_RS09510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC610_RS09515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC610_RS09530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC610_RS09540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC610_RS09545	COG3734	2-keto-3-deoxy-galactonokinase
AC610_RS09555	COG4948	Mandelate Racemase Muconate Lactonizing
AC610_RS09560	COG0800	Aldolase
AC610_RS09600	COG1501	Belongs to the glycosyl hydrolase 31 family
AC610_RS09610	COG1070	Carbohydrate kinase
AC610_RS09615	COG2115	Belongs to the xylose isomerase family
AC610_RS09620	COG0477	Major facilitator Superfamily
AC610_RS09630	COG3328	transposase activity
AC610_RS09650	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC610_RS09655	COG1469	GTP cyclohydrolase I activity
AC610_RS09680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC610_RS09685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC610_RS09690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC610_RS09695	COG0166	Belongs to the GPI family
AC610_RS09715	COG1472	Belongs to the glycosyl hydrolase 3 family
AC610_RS09730	COG5001	Diguanylate cyclase
AC610_RS09730	COG4251	negative regulation of phosphorylation
AC610_RS09730	COG3706	GGDEF domain
AC610_RS09730	COG2203	Gaf domain
AC610_RS09735	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC610_RS09740	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AC610_RS09755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC610_RS09760	COG0671	phosphoesterase, PA-phosphatase related
AC610_RS09770	COG1794	racemase activity, acting on amino acids and derivatives
AC610_RS09780	COG0697	spore germination
AC610_RS09785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC610_RS09790	COG0167	dihydroorotate dehydrogenase activity
AC610_RS09810	COG1012	belongs to the aldehyde dehydrogenase family
AC610_RS09830	COG3328	transposase activity
AC610_RS09845	COG0366	Alpha amylase catalytic
AC610_RS09865	COG1082	Xylose isomerase domain protein TIM barrel
AC610_RS09875	COG2211	Major facilitator Superfamily
AC610_RS09890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC610_RS09895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC610_RS09910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC610_RS09915	COG0072	phenylalanine-tRNA ligase activity
AC610_RS09915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC610_RS09965	COG0438	transferase activity, transferring glycosyl groups
AC610_RS09970	COG0438	transferase activity, transferring glycosyl groups
AC610_RS09980	COG0438	transferase activity, transferring glycosyl groups
AC610_RS10005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC610_RS10015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC610_RS10035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC610_RS10045	COG1960	acyl-CoA dehydrogenase activity
AC610_RS10055	COG3040	lipid binding
AC610_RS10070	COG0322	excinuclease ABC activity
AC610_RS10085	COG0784	Response regulator, receiver
AC610_RS10085	COG4191	Histidine kinase
AC610_RS10105	COG1194	a g-specific adenine glycosylase
AC610_RS10115	COG0552	protein localization to endoplasmic reticulum
AC610_RS10125	COG3938	Belongs to the proline racemase family
AC610_RS10130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC610_RS10145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC610_RS10155	COG0006	proline dipeptidase activity
AC610_RS10175	COG0531	amino acid
AC610_RS10315	COG3328	transposase activity
AC610_RS10350	COG3328	transposase activity
AC610_RS10375	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AC610_RS10380	COG3328	transposase activity
AC610_RS10385	COG0460	homoserine dehydrogenase
AC610_RS10385	COG0527	aspartate kinase activity
AC610_RS10420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC610_RS10425	COG0124	histidyl-tRNA synthetase
AC610_RS10435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC610_RS10440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC610_RS10445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC610_RS10450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC610_RS10450	COG0131	Imidazoleglycerol-phosphate dehydratase
AC610_RS10455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC610_RS10460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC610_RS10465	COG0107	imidazoleglycerol-phosphate synthase activity
AC610_RS10470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC610_RS10470	COG0140	phosphoribosyl-ATP diphosphatase activity
AC610_RS10485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AC610_RS10490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AC610_RS10495	COG0235	Class ii aldolase
AC610_RS10500	COG0531	amino acid
AC610_RS10505	COG0531	amino acid
AC610_RS10515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC610_RS10520	COG0277	FAD linked oxidase domain protein
AC610_RS10540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC610_RS10585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC610_RS10590	COG2258	MOSC domain
AC610_RS10595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC610_RS10600	COG0505	Belongs to the CarA family
AC610_RS10610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC610_RS10615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC610_RS10625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AC610_RS10645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC610_RS10655	COG0784	Response regulator, receiver
AC610_RS10655	COG2205	protein histidine kinase activity
AC610_RS10655	COG2198	Histidine kinase
AC610_RS10660	COG2198	Histidine kinase
AC610_RS10660	COG2205	protein histidine kinase activity
AC610_RS10660	COG0784	Response regulator, receiver
AC610_RS10665	COG1024	Enoyl-CoA hydratase
AC610_RS10670	COG0318	PFAM AMP-dependent synthetase and ligase
AC610_RS10705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC610_RS10715	COG2201	protein-glutamate methylesterase activity
AC610_RS10720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC610_RS10730	COG0840	transmembrane signaling receptor activity
AC610_RS10740	COG0835	chemotaxis
AC610_RS10755	COG0840	transmembrane signaling receptor activity
AC610_RS10760	COG0840	transmembrane signaling receptor activity
AC610_RS10765	COG0840	transmembrane signaling receptor activity
AC610_RS10770	COG0840	transmembrane signaling receptor activity
AC610_RS10775	COG0840	transmembrane signaling receptor activity
AC610_RS10790	COG0840	transmembrane signaling receptor activity
AC610_RS10795	COG0840	transmembrane signaling receptor activity
AC610_RS10800	COG0840	transmembrane signaling receptor activity
AC610_RS10805	COG0840	transmembrane signaling receptor activity
AC610_RS10820	COG0840	transmembrane signaling receptor activity
AC610_RS10835	COG0840	transmembrane signaling receptor activity
AC610_RS10840	COG0840	transmembrane signaling receptor activity
AC610_RS10850	COG0745	RESPONSE REGULATOR receiver
AC610_RS10860	COG0835	chemotaxis
AC610_RS10865	COG1192	Involved in chromosome partitioning
AC610_RS10870	COG1360	Flagellar Motor Protein
AC610_RS10875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC610_RS10920	COG2198	Histidine kinase
AC610_RS10920	COG0784	Response regulator, receiver
AC610_RS10920	COG0643	Histidine kinase
AC610_RS10950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC610_RS10975	COG3039	Transposase
AC610_RS10985	COG1684	flagellar biosynthetic protein fliR
AC610_RS11000	COG3039	Transposase
AC610_RS11010	COG3190	flagellar
AC610_RS11060	COG1677	Flagellar hook-basal body complex protein FliE
AC610_RS11085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC610_RS11095	COG3039	Transposase
AC610_RS11100	COG3328	transposase activity
AC610_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS11135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC610_RS11155	COG2201	protein-glutamate methylesterase activity
AC610_RS11185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AC610_RS11195	COG3039	Transposase
AC610_RS11200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AC610_RS11210	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC610_RS11210	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC610_RS11215	COG1706	bacterial-type flagellum-dependent cell motility
AC610_RS11220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC610_RS11245	COG4787	bacterial-type flagellum-dependent cell motility
AC610_RS11255	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC610_RS11260	COG1558	bacterial-type flagellum-dependent cell motility
AC610_RS11270	COG0835	chemotaxis
AC610_RS11270	COG0784	Response regulator, receiver
AC610_RS11290	COG5002	protein histidine kinase activity
AC610_RS11300	COG4585	Histidine kinase
AC610_RS11320	COG2915	High frequency lysogenization protein hflD homolog
AC610_RS11325	COG0482	sulfurtransferase activity
AC610_RS11340	COG0542	response to heat
AC610_RS11350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC610_RS11360	COG0492	ferredoxin-NADP+ reductase activity
AC610_RS11365	COG1674	ftsk spoiiie
AC610_RS11375	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC610_RS11390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC610_RS11395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC610_RS11400	COG0183	Belongs to the thiolase family
AC610_RS11405	COG1024	Enoyl-CoA hydratase
AC610_RS11405	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC610_RS11440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC610_RS11445	COG1160	GTP binding
AC610_RS11450	COG0303	'Molybdopterin
AC610_RS11455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC610_RS11495	COG0708	Exodeoxyribonuclease III
AC610_RS11505	COG0303	'Molybdopterin
AC610_RS11510	COG0746	molybdenum cofactor guanylyltransferase activity
AC610_RS11535	COG1648	precorrin-2 dehydrogenase activity
AC610_RS11535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC610_RS11545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC610_RS11555	COG2223	nitrite transmembrane transporter activity
AC610_RS11560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC610_RS11570	COG0243	molybdopterin cofactor binding
AC610_RS11585	COG3685	Protein conserved in bacteria
AC610_RS11605	COG5001	Diguanylate cyclase
AC610_RS11615	COG4566	intracellular signal transduction
AC610_RS11670	COG3328	transposase activity
AC610_RS11680	COG3039	Transposase
AC610_RS11685	COG3328	transposase activity
AC610_RS11700	COG3328	transposase activity
AC610_RS11710	COG2226	methyltransferase
AC610_RS11710	COG1073	alpha beta
AC610_RS11725	COG0363	glucosamine-6-phosphate deaminase activity
AC610_RS11745	COG3328	transposase activity
AC610_RS11820	COG3328	transposase activity
AC610_RS11835	COG1192	Involved in chromosome partitioning
AC610_RS11880	COG3318	Belongs to the UPF0149 family
AC610_RS11880	COG3012	SEC-C Motif Domain Protein
AC610_RS11920	COG3328	transposase activity
AC610_RS11950	COG1309	transcriptional regulator
AC610_RS11965	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC610_RS11975	COG0428	transporter
AC610_RS11980	COG3064	Membrane
AC610_RS11990	COG1530	ribonuclease E activity
AC610_RS11995	COG3039	Transposase
AC610_RS12005	COG1054	Belongs to the UPF0176 family
AC610_RS12025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC610_RS12050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC610_RS12055	COG0322	excinuclease ABC activity
AC610_RS12065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC610_RS12070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC610_RS12075	COG1663	tetraacyldisaccharide 4'-kinase activity
AC610_RS12080	COG1132	(ABC) transporter
AC610_RS12090	COG0811	peptide transport
AC610_RS12105	COG1136	(ABC) transporter
AC610_RS12110	COG4591	ABC-type transport system involved in lipoprotein release permease component
AC610_RS12120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC610_RS12125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC610_RS12140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AC610_RS12155	COG0354	folic acid binding
AC610_RS12165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC610_RS12170	COG0837	glucose binding
AC610_RS12175	COG0363	glucosamine-6-phosphate deaminase activity
AC610_RS12180	COG0129	dihydroxy-acid dehydratase activity
AC610_RS12185	COG0800	Aldolase
AC610_RS12260	COG2205	protein histidine kinase activity
AC610_RS12260	COG0784	Response regulator, receiver
AC610_RS12265	COG2183	response to ionizing radiation
AC610_RS12275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC610_RS12275	COG0723	plastoquinol--plastocyanin reductase activity
AC610_RS12290	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC610_RS12300	COG1183	phosphatidylcholine synthase activity
AC610_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS12320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC610_RS12335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC610_RS12350	COG1914	H( )-stimulated, divalent metal cation uptake system
AC610_RS12370	COG2814	Major facilitator Superfamily
AC610_RS12385	COG1335	isochorismatase
AC610_RS12400	COG2197	response regulator
AC610_RS12430	COG0583	DNA-binding transcription factor activity
AC610_RS12435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC610_RS12440	COG3002	Belongs to the UPF0753 family
AC610_RS12450	COG0604	alcohol dehydrogenase
AC610_RS12455	COG3384	dioxygenase
AC610_RS12470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AC610_RS12525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC610_RS12525	COG0519	Catalyzes the synthesis of GMP from XMP
AC610_RS12535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC610_RS12550	COG0475	glutathione-regulated potassium exporter activity
AC610_RS12550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC610_RS12555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC610_RS12565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC610_RS12570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC610_RS12580	COG0776	regulation of translation
AC610_RS12585	COG0539	negative regulation of cytoplasmic translation
AC610_RS12590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AC610_RS12605	COG2957	Belongs to the agmatine deiminase family
AC610_RS12610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC610_RS12635	COG0395	ABC-type sugar transport system, permease component
AC610_RS12640	COG1175	transmembrane transport
AC610_RS12670	COG2350	Protein conserved in bacteria
AC610_RS12675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC610_RS12680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC610_RS12685	COG1187	pseudouridine synthase activity
AC610_RS12700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC610_RS12705	COG0436	Aminotransferase
AC610_RS12710	COG4133	protoheme IX ABC transporter activity
AC610_RS12730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC610_RS12760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC610_RS12770	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AC610_RS12775	COG4988	ABC transporter
AC610_RS12785	COG1294	oxidase, subunit
AC610_RS12815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC610_RS12820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC610_RS12830	COG0165	Argininosuccinate lyase
AC610_RS12835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC610_RS12845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC610_RS12850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC610_RS12860	COG0137	argininosuccinate synthase activity
AC610_RS12865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC610_RS12875	COG0215	cysteine-tRNA ligase activity
AC610_RS12880	COG2166	iron-sulfur cluster assembly
AC610_RS12895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC610_RS12900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC610_RS12930	COG4302	ethanolamine ammonia-lyase activity
AC610_RS12960	COG3039	Transposase
AC610_RS12995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC610_RS13000	COG0402	S-adenosylhomocysteine deaminase activity
AC610_RS13010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC610_RS13015	COG1509	lysine 2,3-aminomutase activity
AC610_RS13020	COG3300	MHYT domain
AC610_RS13020	COG5001	Diguanylate cyclase
AC610_RS13035	COG0483	inositol monophosphate 1-phosphatase activity
AC610_RS13040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC610_RS13055	COG0488	(ABC) transporter
AC610_RS13060	COG0513	Belongs to the DEAD box helicase family
AC610_RS13065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC610_RS13070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC610_RS13095	COG0625	glutathione transferase activity
AC610_RS13110	COG4681	YaeQ
AC610_RS13115	COG2081	HI0933 family
AC610_RS13125	COG0501	Belongs to the peptidase M48B family
AC610_RS13130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC610_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS13160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AC610_RS13165	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC610_RS13170	COG0802	atpase or kinase
AC610_RS13175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC610_RS13175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC610_RS13180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC610_RS13185	COG1570	exodeoxyribonuclease VII activity
AC610_RS13200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC610_RS13245	COG0835	chemotaxis
AC610_RS13250	COG0840	transmembrane signaling receptor activity
AC610_RS13255	COG2094	Belongs to the DNA glycosylase MPG family
AC610_RS13260	COG1201	RNA secondary structure unwinding
AC610_RS13280	COG2969	positive regulation of protein catabolic process
AC610_RS13285	COG0625	glutathione transferase activity
AC610_RS13290	COG2857	Cytochrome c1
AC610_RS13295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC610_RS13300	COG0723	plastoquinol--plastocyanin reductase activity
AC610_RS13310	COG0741	lytic transglycosylase activity
AC610_RS13325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC610_RS13330	COG1702	phosphate starvation-inducible protein PhoH
AC610_RS13340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC610_RS13350	COG4535	Mg2 and Co2 transporter CorC
AC610_RS13365	COG1012	belongs to the aldehyde dehydrogenase family
AC610_RS13370	COG1177	transmembrane transport
AC610_RS13375	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC610_RS13380	COG3842	ATPase activity
AC610_RS13400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AC610_RS13415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC610_RS13420	COG0174	glutamine synthetase
AC610_RS13425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC610_RS13435	COG2703	oxygen carrier activity
AC610_RS13440	COG0477	Major facilitator Superfamily
AC610_RS13450	COG0243	molybdopterin cofactor binding
AC610_RS13455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC610_RS13460	COG2223	nitrite transmembrane transporter activity
AC610_RS13475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC610_RS13485	COG2733	membrane
AC610_RS13490	COG5002	protein histidine kinase activity
AC610_RS13490	COG2205	protein histidine kinase activity
AC610_RS13490	COG0784	Response regulator, receiver
AC610_RS13500	COG0477	Major facilitator Superfamily
AC610_RS13505	COG0840	transmembrane signaling receptor activity
AC610_RS13535	COG2902	Dehydrogenase
AC610_RS13545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC610_RS13550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC610_RS13555	COG1609	Transcriptional regulator
AC610_RS13560	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC610_RS13560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC610_RS13565	COG1105	Belongs to the carbohydrate kinase PfkB family
AC610_RS13570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC610_RS13570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC610_RS13585	COG3328	transposase activity
AC610_RS13595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC610_RS13605	COG1862	Preprotein translocase
AC610_RS13610	COG0343	queuine tRNA-ribosyltransferase activity
AC610_RS13615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC610_RS13655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC610_RS13660	COG3291	Pkd domain containing protein
AC610_RS13665	COG0405	Gamma-glutamyltransferase
AC610_RS13670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC610_RS13685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC610_RS13690	COG0742	ribosomal rna small subunit methyltransferase
AC610_RS13695	COG0326	Molecular chaperone. Has ATPase activity
AC610_RS13820	COG3702	type iv secretory pathway
AC610_RS13840	COG2948	multi-organism process
AC610_RS13860	COG3505	Type IV secretory pathway VirD4
AC610_RS13875	COG0556	nucleotide-excision repair
AC610_RS14055	COG3179	chitinase
AC610_RS14100	COG4695	Portal protein
AC610_RS14175	COG3275	phosphorelay sensor kinase activity
AC610_RS14180	COG1611	Belongs to the LOG family
AC610_RS14195	COG2095	MarC family integral membrane protein
AC610_RS14205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC610_RS14240	COG1185	polyribonucleotide nucleotidyltransferase activity
AC610_RS14245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC610_RS14250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC610_RS14255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC610_RS14260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC610_RS14265	COG0195	Participates in both transcription termination and antitermination
AC610_RS14270	COG0779	Required for maturation of 30S ribosomal subunits
AC610_RS14280	COG1007	ATP synthesis coupled electron transport
AC610_RS14305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC610_RS14310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC610_RS14320	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC610_RS14325	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC610_RS14330	COG0649	NAD binding
AC610_RS14335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC610_RS14340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC610_RS14345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC610_RS14360	COG0149	triose-phosphate isomerase activity
AC610_RS14365	COG4221	oxidoreductase activity
AC610_RS14395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC610_RS14400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC610_RS14405	COG0159	tryptophan synthase activity
AC610_RS14415	COG0133	tryptophan synthase activity
AC610_RS14425	COG0135	phosphoribosylanthranilate isomerase activity
AC610_RS14430	COG0101	tRNA pseudouridine synthase activity
AC610_RS14445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC610_RS14450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC610_RS14455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC610_RS14460	COG2890	protein-(glutamine-N5) methyltransferase activity
AC610_RS14470	COG0688	phosphatidylethanolamine metabolic process
AC610_RS14485	COG0433	COG0433 Predicted ATPase
AC610_RS14510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC610_RS14515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC610_RS14540	COG0717	Belongs to the dCTP deaminase family
AC610_RS14550	COG0489	protein tyrosine kinase activity
AC610_RS14590	COG3590	peptidase
AC610_RS14615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC610_RS14620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC610_RS14625	COG2311	Membrane
AC610_RS14630	COG1047	Peptidyl-prolyl cis-trans
AC610_RS14635	COG0791	NLP P60 protein
AC610_RS14640	COG0791	NLP P60 protein
AC610_RS14650	COG4106	trans-aconitate 2-methyltransferase activity
AC610_RS14655	COG1301	dicarboxylic acid transport
AC610_RS14660	COG1785	Belongs to the alkaline phosphatase family
AC610_RS14670	COG0037	tRNA processing
AC610_RS14675	COG1722	exodeoxyribonuclease VII activity
AC610_RS14680	COG0142	geranyltranstransferase activity
AC610_RS14685	COG4104	PAAR repeat-containing protein
AC610_RS14695	COG0312	modulator of DNA gyrase
AC610_RS14700	COG3028	Belongs to the UPF0307 family
AC610_RS14705	COG0312	modulator of DNA gyrase
AC610_RS14715	COG3164	Protein of unknown function
AC610_RS14725	COG0424	maF-like protein
AC610_RS14730	COG2968	Membrane
AC610_RS14745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC610_RS14760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC610_RS14780	COG0495	leucyl-tRNA aminoacylation
AC610_RS14790	COG3118	belongs to the thioredoxin family
AC610_RS14815	COG2155	Conserved Protein
AC610_RS14865	COG1132	(ABC) transporter
AC610_RS14895	COG0745	RESPONSE REGULATOR receiver
AC610_RS14900	COG5002	protein histidine kinase activity
AC610_RS14900	COG5000	phosphorelay sensor kinase activity
AC610_RS14905	COG0475	glutathione-regulated potassium exporter activity
AC610_RS14915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC610_RS14935	COG1187	pseudouridine synthase activity
AC610_RS14940	COG5002	protein histidine kinase activity
AC610_RS14940	COG5001	Diguanylate cyclase
AC610_RS14950	COG1595	DNA-templated transcription, initiation
AC610_RS15070	COG0667	Aldo Keto reductase
AC610_RS15075	COG2814	Major facilitator Superfamily
AC610_RS15080	COG0583	DNA-binding transcription factor activity
AC610_RS15090	COG2207	Transcriptional regulator
AC610_RS15100	COG1309	transcriptional regulator
AC610_RS15110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC610_RS15125	COG0735	belongs to the Fur family
AC610_RS15130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC610_RS15155	COG4452	Inner membrane protein CreD
AC610_RS15175	COG0745	RESPONSE REGULATOR receiver
AC610_RS15180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC610_RS15190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC610_RS15200	COG2198	Histidine kinase
AC610_RS15200	COG0643	Histidine kinase
AC610_RS15205	COG0840	transmembrane signaling receptor activity
AC610_RS15210	COG0835	chemotaxis
AC610_RS15215	COG2202	Pas domain
AC610_RS15215	COG2200	EAL domain
AC610_RS15215	COG2199	diguanylate cyclase activity
AC610_RS15220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC610_RS15225	COG2201	protein-glutamate methylesterase activity
AC610_RS15235	COG3590	peptidase
AC610_RS15250	COG1515	deoxyribonuclease V activity
AC610_RS15260	COG1741	Belongs to the pirin family
AC610_RS15275	COG1741	Belongs to the pirin family
AC610_RS15280	COG1966	Carbon starvation protein
AC610_RS15285	COG2879	small protein
AC610_RS15330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC610_RS15335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC610_RS15340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC610_RS15345	COG2080	2 iron, 2 sulfur cluster binding
AC610_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS15350	COG0604	alcohol dehydrogenase
AC610_RS15350	COG3321	synthase
AC610_RS15355	COG3706	GGDEF domain
AC610_RS15355	COG5001	Diguanylate cyclase
AC610_RS15355	COG4251	negative regulation of phosphorylation
AC610_RS15355	COG2203	Gaf domain
AC610_RS15360	COG0629	single-stranded DNA binding
AC610_RS15365	COG0142	geranyltranstransferase activity
AC610_RS15375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC610_RS15390	COG0527	aspartate kinase activity
AC610_RS15395	COG0384	phenazine biosynthesis protein PhzF
AC610_RS15400	COG0384	phenazine biosynthesis protein PhzF
AC610_RS15410	COG1764	response to oxidative stress
AC610_RS15415	COG0540	Belongs to the ATCase OTCase family
AC610_RS15420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC610_RS15425	COG1678	Uncharacterized ACR, COG1678
AC610_RS15430	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AC610_RS15435	COG0519	Catalyzes the synthesis of GMP from XMP
AC610_RS15460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC610_RS15475	COG0739	heme binding
AC610_RS15495	COG0693	protein deglycase activity
AC610_RS15505	COG1959	2 iron, 2 sulfur cluster binding
AC610_RS15510	COG0719	Fe-S assembly protein
AC610_RS15515	COG0396	ATPase activity
AC610_RS15520	COG0719	Fe-S assembly protein
AC610_RS15525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC610_RS15535	COG0456	acetyltransferase
AC610_RS15540	COG2146	nitrite reductase [NAD(P)H] activity
AC610_RS15545	COG4774	siderophore transport
AC610_RS15550	COG3128	pkhd-type hydroxylase
AC610_RS15575	COG3328	transposase activity
AC610_RS15580	COG1477	protein flavinylation
AC610_RS15585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC610_RS15595	COG1555	photosystem II stabilization
AC610_RS15615	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC610_RS15625	COG0628	permease
AC610_RS15635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC610_RS15650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC610_RS15670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC610_RS15675	COG0271	Belongs to the BolA IbaG family
AC610_RS15685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AC610_RS15695	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC610_RS15700	COG1137	ATPase activity
AC610_RS15715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC610_RS15720	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC610_RS15725	COG1660	Displays ATPase and GTPase activities
AC610_RS15735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC610_RS15750	COG2239	Acts as a magnesium transporter
AC610_RS15760	COG1294	oxidase, subunit
AC610_RS15815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC610_RS15835	COG2951	lytic endotransglycosylase activity
AC610_RS15930	COG1113	amino acid transport
AC610_RS15965	COG2197	response regulator
AC610_RS15970	COG0531	amino acid
AC610_RS16060	COG2814	Major facilitator Superfamily
AC610_RS16070	COG0754	glutathionylspermidine amidase activity
AC610_RS16095	COG1842	Phage shock protein A
AC610_RS16105	COG0259	pyridoxamine-phosphate oxidase activity
AC610_RS16110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC610_RS16115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC610_RS16125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC610_RS16130	COG2814	Major facilitator Superfamily
AC610_RS16155	COG0784	Response regulator, receiver
AC610_RS16155	COG2198	Histidine kinase
AC610_RS16155	COG2205	protein histidine kinase activity
AC610_RS16160	COG2353	YceI-like domain
AC610_RS16180	COG1760	l-serine dehydratase
AC610_RS16190	COG0527	aspartate kinase activity
AC610_RS16190	COG0460	homoserine dehydrogenase
AC610_RS16195	COG0626	cystathionine gamma-synthase activity
AC610_RS16200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC610_RS16205	COG0739	heme binding
AC610_RS16210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC610_RS16215	COG1272	protein, Hemolysin III
AC610_RS16220	COG2982	Protein involved in outer membrane biogenesis
AC610_RS16225	COG0516	GMP reductase activity
AC610_RS16225	COG0517	IMP dehydrogenase activity
AC610_RS16230	COG0463	Glycosyl transferase, family 2
AC610_RS16235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC610_RS16240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC610_RS16250	COG4771	TonB-dependent receptor
AC610_RS16255	COG1309	transcriptional regulator
AC610_RS16265	COG1960	acyl-CoA dehydrogenase activity
AC610_RS16295	COG3328	transposase activity
AC610_RS16325	COG0509	glycine decarboxylation via glycine cleavage system
AC610_RS16330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC610_RS16340	COG0330	HflC and HflK could
AC610_RS16345	COG1742	UPF0060 membrane protein
AC610_RS16350	COG3956	TIGRFAM MazG family protein
AC610_RS16360	COG0494	nUDIX hydrolase
AC610_RS16370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC610_RS16375	COG0837	glucose binding
AC610_RS16410	COG1388	LysM domain
AC610_RS16410	COG3858	chitin binding
AC610_RS16425	COG1472	Belongs to the glycosyl hydrolase 3 family
AC610_RS16435	COG3537	Alpha-1,2-mannosidase
AC610_RS16480	COG3142	Participates in the control of copper homeostasis
AC610_RS16485	COG1446	asparaginase
AC610_RS16515	COG2198	Histidine kinase
AC610_RS16515	COG0784	Response regulator, receiver
AC610_RS16515	COG0643	Histidine kinase
AC610_RS16520	COG0840	transmembrane signaling receptor activity
AC610_RS16525	COG0835	chemotaxis
AC610_RS16540	COG0189	ligase activity
AC610_RS16550	COG1397	ADP-ribosylglycohydrolase
AC610_RS16560	COG1199	ATP-dependent helicase activity
AC610_RS16570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC610_RS16575	COG1215	transferase activity, transferring glycosyl groups
AC610_RS16590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC610_RS16600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC610_RS16605	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC610_RS16610	COG0535	radical SAM domain protein
AC610_RS16615	COG0535	radical SAM domain protein
AC610_RS16630	COG0837	glucose binding
AC610_RS16640	COG3328	transposase activity
AC610_RS16650	COG1643	Atp-dependent helicase
AC610_RS16655	COG0783	Belongs to the Dps family
AC610_RS16660	COG0514	ATP-dependent DNA helicase (RecQ)
AC610_RS16705	COG0840	transmembrane signaling receptor activity
AC610_RS16725	COG3920	Histidine kinase
AC610_RS16730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AC610_RS16740	COG0602	queuosine metabolic process
AC610_RS16750	COG2885	chlorophyll binding
AC610_RS16755	COG0823	Involved in the tonB-independent uptake of proteins
AC610_RS16765	COG0848	biopolymer transport protein
AC610_RS16775	COG0824	Thioesterase
AC610_RS16780	COG2255	four-way junction helicase activity
AC610_RS16790	COG3158	transport of potassium into the cell
AC610_RS16795	COG0632	four-way junction helicase activity
AC610_RS16800	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC610_RS16805	COG0217	transcriptional regulatory protein
AC610_RS16820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC610_RS16835	COG0477	Major facilitator Superfamily
AC610_RS16860	COG2755	lipolytic protein G-D-S-L family
AC610_RS16860	COG0657	acetylesterase activity
AC610_RS16880	COG0488	(ABC) transporter
AC610_RS16915	COG4651	solute:proton antiporter activity
AC610_RS16915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC610_RS16940	COG4772	TonB-dependent receptor
AC610_RS16950	COG4264	IucA IucC family
AC610_RS16965	COG0019	diaminopimelate decarboxylase activity
AC610_RS16990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC610_RS17000	COG1492	cobalamin metabolic process
AC610_RS17010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC610_RS17030	COG4206	TonB-dependent receptor
AC610_RS17040	COG0542	response to heat
AC610_RS17085	COG1877	trehalose-phosphatase activity
AC610_RS17090	COG3387	PFAM Glycoside hydrolase 15-related
AC610_RS17120	COG0840	transmembrane signaling receptor activity
AC610_RS17125	COG3011	Protein conserved in bacteria
AC610_RS17140	COG0564	pseudouridine synthase activity
AC610_RS17145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC610_RS17155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC610_RS17155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC610_RS17170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC610_RS17175	COG0045	succinate-CoA ligase (ADP-forming) activity
AC610_RS17220	COG3328	transposase activity
AC610_RS17230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC610_RS17235	COG0237	dephospho-CoA kinase activity
AC610_RS17265	COG0745	RESPONSE REGULATOR receiver
AC610_RS17275	COG0189	ligase activity
AC610_RS17315	COG2003	Belongs to the UPF0758 family
AC610_RS17340	COG3039	Transposase
AC610_RS17350	COG3328	transposase activity
AC610_RS17360	COG3328	transposase activity
AC610_RS17425	COG1192	Involved in chromosome partitioning
AC610_RS17495	COG0270	DNA (cytosine-5-)-methyltransferase activity
AC610_RS17600	COG3328	transposase activity
AC610_RS17765	COG5001	Diguanylate cyclase
AC610_RS17910	COG0583	DNA-binding transcription factor activity
AC610_RS17935	COG0582	viral genome integration into host DNA
AC610_RS17955	COG2022	thiamine diphosphate biosynthetic process
AC610_RS17960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC610_RS17965	COG3273	potassium ion transport
AC610_RS17965	COG0471	metal ion transport
AC610_RS17990	COG1970	mechanosensitive ion channel activity
AC610_RS18000	COG1609	Transcriptional regulator
AC610_RS18010	COG3250	beta-galactosidase activity
AC610_RS18015	COG4948	Mandelate Racemase Muconate Lactonizing
AC610_RS18025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC610_RS18035	COG0308	aminopeptidase N
AC610_RS18040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC610_RS18050	COG2895	sulfate adenylyltransferase (ATP) activity
AC610_RS18050	COG0529	Catalyzes the synthesis of activated sulfate
AC610_RS18055	COG0175	sulfate reduction
AC610_RS18060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC610_RS18065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC610_RS18070	COG0175	sulfate reduction
AC610_RS18090	COG0784	Response regulator, receiver
AC610_RS18090	COG2198	Histidine kinase
AC610_RS18090	COG2205	protein histidine kinase activity
AC610_RS18110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC610_RS18110	COG1648	precorrin-2 dehydrogenase activity
AC610_RS18125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AC610_RS18130	COG3588	fructose-bisphosphate aldolase
AC610_RS18140	COG0469	pyruvate kinase activity
AC610_RS18150	COG0126	phosphoglycerate kinase activity
AC610_RS18180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC610_RS18190	COG3047	cAMP biosynthetic process
AC610_RS18205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC610_RS18205	COG3453	Protein conserved in bacteria
AC610_RS18210	COG0725	ABC transporter, periplasmic molybdate-binding protein
AC610_RS18215	COG4149	molybdate abc transporter
AC610_RS18220	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AC610_RS18240	COG0642	Histidine kinase
AC610_RS18265	COG1022	Amp-dependent synthetase and ligase
AC610_RS18290	COG1376	ErfK ybiS ycfS ynhG family protein
AC610_RS18295	COG0739	heme binding
AC610_RS18310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC610_RS18315	COG1301	dicarboxylic acid transport
AC610_RS18325	COG2304	oxidoreductase activity
AC610_RS18345	COG0714	Associated with various cellular activities
AC610_RS18375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC610_RS18400	COG1957	nucleoside hydrolase
AC610_RS18405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC610_RS18415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC610_RS18430	COG1561	YicC-like family, N-terminal region
AC610_RS18435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC610_RS18445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC610_RS18450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC610_RS18465	COG0006	proline dipeptidase activity
AC610_RS18475	COG0006	proline dipeptidase activity
AC610_RS18480	COG3079	Belongs to the UPF0149 family
AC610_RS18500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC610_RS18520	COG2912	Transglutaminase-like superfamily
AC610_RS18530	COG1773	rubredoxin
AC610_RS18535	COG0352	thiamine-phosphate diphosphorylase activity
AC610_RS18565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC610_RS18575	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AC610_RS18580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC610_RS18610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC610_RS18615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC610_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS18630	COG0671	phosphoesterase, PA-phosphatase related
AC610_RS18640	COG3781	membrane
AC610_RS18650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC610_RS18655	COG0563	adenylate kinase activity
AC610_RS18670	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AC610_RS18680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC610_RS18700	COG3710	Transcriptional regulator
AC610_RS18705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC610_RS18720	COG0840	transmembrane signaling receptor activity
AC610_RS18725	COG0405	Gamma-glutamyltransferase
AC610_RS18730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC610_RS18750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC610_RS18755	COG0473	3-isopropylmalate dehydrogenase activity
AC610_RS18760	COG0066	3-isopropylmalate dehydratase activity
AC610_RS18765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC610_RS18785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC610_RS18790	COG1538	Outer membrane efflux protein
AC610_RS18795	COG1519	Transferase
AC610_RS18800	COG1560	Kdo2-lipid A biosynthetic process
AC610_RS18825	COG0280	phosphate acetyltransferase
AC610_RS18825	COG0281	malic enzyme
AC610_RS18830	COG1301	dicarboxylic acid transport
AC610_RS18855	COG0583	DNA-binding transcription factor activity
AC610_RS18865	COG0667	Aldo Keto reductase
AC610_RS18880	COG2197	response regulator
AC610_RS18895	COG0642	Histidine kinase
AC610_RS18915	COG2851	Citrate transporter
AC610_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS18925	COG1609	Transcriptional regulator
AC610_RS18930	COG2211	Major facilitator Superfamily
AC610_RS18955	COG1162	GTPase activity
AC610_RS18960	COG0436	Aminotransferase
AC610_RS18975	COG0726	polysaccharide deacetylase
AC610_RS18980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC610_RS18995	COG3964	amidohydrolase
AC610_RS19000	COG0402	S-adenosylhomocysteine deaminase activity
AC610_RS19030	COG3328	transposase activity
AC610_RS19045	COG1307	EDD domain protein, DegV family
AC610_RS19065	COG3791	Glutathione-dependent formaldehyde-activating
AC610_RS19095	COG2205	protein histidine kinase activity
AC610_RS19110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC610_RS19125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC610_RS19135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC610_RS19140	COG1012	belongs to the aldehyde dehydrogenase family
AC610_RS19145	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC610_RS19165	COG1183	phosphatidylcholine synthase activity
AC610_RS19175	COG0442	prolyl-tRNA aminoacylation
AC610_RS19190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC610_RS19195	COG1127	ABC transporter
AC610_RS19200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC610_RS19200	COG3218	ABC-type transport auxiliary lipoprotein component
AC610_RS19230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC610_RS19235	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC610_RS19235	COG0662	Cupin 2, conserved barrel domain protein
AC610_RS19265	COG2086	electron transfer activity
AC610_RS19280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC610_RS19280	COG0546	phosphoglycolate phosphatase activity
AC610_RS19285	COG0277	FAD linked oxidase domain protein
AC610_RS19295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC610_RS19330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC610_RS19335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AC610_RS19340	COG0438	transferase activity, transferring glycosyl groups
AC610_RS19360	COG0438	transferase activity, transferring glycosyl groups
AC610_RS19370	COG0626	cystathionine gamma-synthase activity
AC610_RS19400	COG0625	glutathione transferase activity
AC610_RS19415	COG0513	Belongs to the DEAD box helicase family
AC610_RS19420	COG0720	synthase
AC610_RS19430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC610_RS19440	COG1956	GAF domain-containing protein
AC610_RS19455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC610_RS19460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC610_RS19470	COG4991	sh3 domain protein
AC610_RS19480	COG0339	signal peptide processing
AC610_RS19495	COG2132	Multicopper oxidase
AC610_RS19530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC610_RS19535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC610_RS19540	COG1136	(ABC) transporter
AC610_RS19545	COG0577	efflux transmembrane transporter activity
AC610_RS19545	COG1136	(ABC) transporter
AC610_RS19565	COG4191	Histidine kinase
AC610_RS19570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC610_RS19595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC610_RS19600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC610_RS19605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC610_RS19610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC610_RS19615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC610_RS19630	COG0356	it plays a direct role in the translocation of protons across the membrane
AC610_RS19650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC610_RS19660	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC610_RS19700	COG2011	ABC-type metal ion transport system permease component
AC610_RS19705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC610_RS19710	COG0697	spore germination
AC610_RS19715	COG1666	GTP binding
AC610_RS19725	COG5002	protein histidine kinase activity
AC610_RS19725	COG2198	Histidine kinase
AC610_RS19725	COG0784	Response regulator, receiver
AC610_RS19750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC610_RS19755	COG1187	pseudouridine synthase activity
AC610_RS19760	COG2813	Specifically methylates the guanine in position
AC610_RS19775	COG3039	Transposase
AC610_RS19780	COG3328	transposase activity
AC610_RS19795	COG2202	Pas domain
AC610_RS19795	COG2205	protein histidine kinase activity
AC610_RS19815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC610_RS19820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC610_RS19875	COG0842	Transport permease protein
AC610_RS19880	COG1131	(ABC) transporter
AC610_RS19885	COG0025	NhaP-type Na H and K H
AC610_RS19895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AC610_RS19900	COG1573	uracil-dna glycosylase
AC610_RS19910	COG3384	dioxygenase
AC610_RS19920	COG0583	DNA-binding transcription factor activity
AC610_RS19930	COG0667	Aldo Keto reductase
AC610_RS19945	COG3590	peptidase
AC610_RS19960	COG0531	amino acid
AC610_RS19975	COG2972	Histidine kinase
AC610_RS19995	COG3685	Protein conserved in bacteria
AC610_RS20000	COG3546	catalase activity
AC610_RS20050	COG1271	oxidase subunit
AC610_RS20055	COG1294	oxidase, subunit
AC610_RS20070	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS20090	COG1063	alcohol dehydrogenase
AC610_RS20100	COG3328	transposase activity
AC610_RS20170	COG0251	oxidation-reduction process
AC610_RS20195	COG0659	secondary active sulfate transmembrane transporter activity
AC610_RS20200	COG0038	chloride channel
AC610_RS20210	COG0024	Methionine aminopeptidase
AC610_RS20245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC610_RS20250	COG1490	D-aminoacyl-tRNA deacylase activity
AC610_RS20255	COG1560	Kdo2-lipid A biosynthetic process
AC610_RS20300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC610_RS20300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC610_RS20305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC610_RS20310	COG0242	peptide deformylase activity
AC610_RS20315	COG1652	LysM domain
AC610_RS20320	COG0758	DNA mediated transformation
AC610_RS20340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC610_RS20340	COG1754	DNA topoisomerase type I activity
AC610_RS20345	COG0009	L-threonylcarbamoyladenylate synthase
AC610_RS20360	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS20370	COG0616	signal peptide processing
AC610_RS20375	COG0534	Mate efflux family protein
AC610_RS20395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AC610_RS20400	COG0625	glutathione transferase activity
AC610_RS20420	COG2860	membrane
AC610_RS20425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC610_RS20430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC610_RS20435	COG3437	response regulator, receiver
AC610_RS20440	COG2177	Part of the ABC transporter FtsEX involved in
AC610_RS20445	COG2884	Cell division ATP-binding protein ftsE
AC610_RS20450	COG0513	Belongs to the DEAD box helicase family
AC610_RS20455	COG3118	belongs to the thioredoxin family
AC610_RS20460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC610_RS20470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AC610_RS20495	COG1652	LysM domain
AC610_RS20500	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC610_RS20500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC610_RS20505	COG1473	amidohydrolase
AC610_RS20510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC610_RS20515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC610_RS20535	COG5383	Protein conserved in bacteria
AC610_RS20560	COG3328	transposase activity
AC610_RS20580	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AC610_RS20585	COG3023	N-Acetylmuramoyl-L-alanine amidase
AC610_RS20605	COG0531	amino acid
AC610_RS20625	COG3328	transposase activity
AC610_RS20630	COG4682	membrane
AC610_RS20635	COG2133	pyrroloquinoline quinone binding
AC610_RS20660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC610_RS20665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC610_RS20675	COG1610	YqeY-like protein
AC610_RS20685	COG1295	ribonuclease BN
AC610_RS20690	COG0358	DNA primase activity
AC610_RS20705	COG0109	protoheme IX farnesyltransferase activity
AC610_RS20735	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC610_RS20750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC610_RS20790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC610_RS20795	COG0739	heme binding
AC610_RS20800	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AC610_RS20810	COG2211	Major facilitator Superfamily
AC610_RS20815	COG0708	Exodeoxyribonuclease III
AC610_RS20820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC610_RS20830	COG1192	Involved in chromosome partitioning
AC610_RS20835	COG1475	DNA binding
AC610_RS20850	COG0463	Glycosyl transferase, family 2
AC610_RS20870	COG0756	dUTP diphosphatase activity
AC610_RS20875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AC610_RS20880	COG2003	Belongs to the UPF0758 family
AC610_RS20885	COG0018	arginyl-trna synthetase
AC610_RS20900	COG4221	oxidoreductase activity
AC610_RS20905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC610_RS20905	COG2755	lipolytic protein G-D-S-L family
AC610_RS20915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AC610_RS20920	COG1166	arginine decarboxylase activity
AC610_RS20925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC610_RS20945	COG3291	Pkd domain containing protein
AC610_RS20945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AC610_RS20965	COG0606	chelatase, subunit chli
AC610_RS20980	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC610_RS21015	COG1690	Belongs to the RtcB family
AC610_RS21055	COG1090	epimerase
AC610_RS21065	COG0642	Histidine kinase
AC610_RS21085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC610_RS21110	COG1011	Hydrolase
AC610_RS21115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC610_RS21130	COG0753	catalase activity
AC610_RS21145	COG2197	response regulator
AC610_RS21150	COG4585	Histidine kinase
AC610_RS21155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC610_RS21160	COG1136	(ABC) transporter
AC610_RS21185	COG0697	spore germination
AC610_RS21210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC610_RS21215	COG0180	Tryptophanyl-tRNA synthetase
AC610_RS21220	COG3237	CsbD-like
AC610_RS21265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC610_RS21280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC610_RS21285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AC610_RS21285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AC610_RS21300	COG3228	Belongs to the MtfA family
AC610_RS21330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC610_RS21370	COG3328	transposase activity
AC610_RS21385	COG1199	ATP-dependent helicase activity
AC610_RS21400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC610_RS21490	COG4555	ABC transporter
AC610_RS21500	COG1476	TRANSCRIPTIONal
AC610_RS21520	COG1230	cation diffusion facilitator family transporter
AC610_RS21525	COG0543	2 iron, 2 sulfur cluster binding
AC610_RS21525	COG0633	Ferredoxin
AC610_RS21530	COG1131	(ABC) transporter
AC610_RS21535	COG0842	Transport permease protein
AC610_RS21540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC610_RS21575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC610_RS21595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC610_RS21600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC610_RS21615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC610_RS21615	COG1042	CoA-binding domain protein
AC610_RS21615	COG0045	succinate-CoA ligase (ADP-forming) activity
AC610_RS21620	COG2239	Acts as a magnesium transporter
AC610_RS21660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC610_RS21665	COG3387	PFAM Glycoside hydrolase 15-related
AC610_RS21680	COG3100	YcgL domain-containing protein
AC610_RS21685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC610_RS21695	COG0463	Glycosyl transferase, family 2
AC610_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS21750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC610_RS21765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC610_RS21815	COG0408	coproporphyrinogen oxidase activity
AC610_RS21855	COG0515	serine threonine protein kinase
AC610_RS21860	COG0631	protein serine/threonine phosphatase activity
AC610_RS21885	COG0667	Aldo Keto reductase
AC610_RS21890	COG0583	DNA-binding transcription factor activity
AC610_RS21965	COG0154	amidase activity
AC610_RS21990	COG3328	transposase activity
AC610_RS22075	COG0210	DNA helicase
AC610_RS22090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC610_RS22095	COG0583	DNA-binding transcription factor activity
AC610_RS22100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC610_RS22115	COG2159	amidohydrolase
AC610_RS22145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC610_RS22170	COG0357	Ribosomal RNA small subunit methyltransferase G
AC610_RS22175	COG3540	Alkaline phosphatase
AC610_RS22185	COG2091	lysine biosynthetic process via aminoadipic acid
AC610_RS22200	COG0708	Exodeoxyribonuclease III
AC610_RS22205	COG1846	Transcriptional regulator
AC610_RS22205	COG1940	carbohydrate kinase activity
AC610_RS22225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC610_RS22230	COG3162	membrane
AC610_RS22240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC610_RS22275	COG3507	Belongs to the glycosyl hydrolase 43 family
AC610_RS22295	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS22300	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC610_RS22305	COG4948	Mandelate Racemase Muconate Lactonizing
AC610_RS22310	COG3254	rhamnose metabolic process
AC610_RS22315	COG0738	Major facilitator superfamily
AC610_RS22320	COG1414	Transcriptional regulator
AC610_RS22325	COG1917	Cupin 2, conserved barrel domain protein
AC610_RS22325	COG2207	Transcriptional regulator
AC610_RS22335	COG1971	Probably functions as a manganese efflux pump
AC610_RS22340	COG2205	protein histidine kinase activity
AC610_RS22355	COG3459	Glycosyltransferase 36 associated
AC610_RS22360	COG2211	Major facilitator Superfamily
AC610_RS22365	COG3265	gluconokinase activity
AC610_RS22375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC610_RS22395	COG2911	Protein conserved in bacteria
AC610_RS22400	COG0729	surface antigen
AC610_RS22405	COG4771	TonB-dependent receptor
AC610_RS22410	COG0457	Tetratricopeptide repeat
AC610_RS22420	COG0752	glycyl-tRNA synthetase alpha subunit
AC610_RS22425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC610_RS22440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC610_RS22440	COG0519	Catalyzes the synthesis of GMP from XMP
AC610_RS22455	COG0805	protein transport
AC610_RS22460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC610_RS22465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC610_RS22475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC610_RS22505	COG2974	May be involved in recombination
AC610_RS22510	COG0037	tRNA processing
AC610_RS22520	COG2115	Belongs to the xylose isomerase family
AC610_RS22530	COG3661	Belongs to the glycosyl hydrolase 67 family
AC610_RS22540	COG4948	Mandelate Racemase Muconate Lactonizing
AC610_RS22550	COG1472	Belongs to the glycosyl hydrolase 3 family
AC610_RS22555	COG0246	Mannitol dehydrogenase
AC610_RS22620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC610_RS22645	COG3386	PFAM SMP-30 Gluconolaconase
AC610_RS22655	COG3250	beta-galactosidase activity
AC610_RS22660	COG1904	glucuronate isomerase
AC610_RS22665	COG3693	PFAM glycoside hydrolase, family 10
AC610_RS22675	COG3693	PFAM glycoside hydrolase, family 10
AC610_RS22690	COG2211	Major facilitator Superfamily
AC610_RS22775	COG2937	Belongs to the GPAT DAPAT family
AC610_RS22810	COG0284	orotidine-5'-phosphate decarboxylase activity
AC610_RS22815	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AC610_RS22830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC610_RS22880	COG0210	DNA helicase
AC610_RS22885	COG1435	thymidine kinase activity
AC610_RS22895	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AC610_RS22920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC610_RS22950	COG3135	benzoate transporter
AC610_RS22980	COG0676	glucose-6-phosphate 1-epimerase activity
AC610_RS22990	COG3012	SEC-C Motif Domain Protein
AC610_RS23035	COG3328	transposase activity
AC610_RS23060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC610_RS23070	COG4221	oxidoreductase activity
AC610_RS23075	COG0583	DNA-binding transcription factor activity
AC610_RS23085	COG0477	Major facilitator Superfamily
AC610_RS23090	COG1289	transmembrane transporter activity
AC610_RS23100	COG1566	PFAM secretion protein HlyD family protein
AC610_RS23115	COG0302	gtp cyclohydrolase
AC610_RS23130	COG3328	transposase activity
AC610_RS23140	COG0730	response to heat
AC610_RS23155	COG3328	transposase activity
AC610_RS23180	COG0564	pseudouridine synthase activity
AC610_RS23295	COG4790	Type iii secretion
AC610_RS23455	COG3039	Transposase
AC610_RS23575	COG0439	Biotin carboxylase
AC610_RS23600	COG1028	Short-chain dehydrogenase reductase Sdr
AC610_RS23660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC610_RS23665	COG1074	ATP-dependent DNA helicase activity
AC610_RS23670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC610_RS23705	COG1127	ABC transporter
AC610_RS23710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC610_RS23715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC610_RS23730	COG2853	Lipoprotein
AC610_RS23745	COG0386	Belongs to the glutathione peroxidase family
AC610_RS23755	COG1322	Protein conserved in bacteria
AC610_RS23765	COG0583	DNA-binding transcription factor activity
AC610_RS23785	COG0531	amino acid
AC610_RS23790	COG3537	Alpha-1,2-mannosidase
AC610_RS23805	COG2203	Gaf domain
AC610_RS23805	COG2199	diguanylate cyclase activity
AC610_RS23810	COG3835	regulator
AC610_RS23815	COG1929	Belongs to the glycerate kinase type-1 family
AC610_RS23835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC610_RS23845	COG0861	Integral membrane protein TerC family
AC610_RS23865	COG0584	glycerophosphoryl diester phosphodiesterase
AC610_RS23880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC610_RS23885	COG0726	polysaccharide deacetylase
AC610_RS23890	COG0706	membrane insertase activity
AC610_RS23895	COG0594	ribonuclease P activity
AC610_RS24045	COG3328	transposase activity
AC610_RS24090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC610_RS24095	COG4691	Plasmid stability protein
AC610_RS24100	COG1487	ribonuclease activity
AC610_RS24170	COG3846	protein secretion by the type IV secretion system
AC610_RS24185	COG3451	type IV secretory pathway VirB4
AC610_RS24200	COG4962	Type ii secretion system protein e
AC610_RS24355	COG3328	transposase activity
AC610_RS24370	COG3039	Transposase
AC610_RS24395	COG3328	transposase activity
AC610_RS24520	COG1487	ribonuclease activity
AC610_RS24525	COG4691	Plasmid stability protein
AC610_RS24530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs