locus-tag	class	description
AC611_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC611_RS00025	COG0187	DNA topoisomerase II activity
AC611_RS00035	COG0501	Belongs to the peptidase M48B family
AC611_RS00090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC611_RS00100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC611_RS00145	COG0793	Belongs to the peptidase S41A family
AC611_RS00150	COG4942	peptidase
AC611_RS00160	COG2234	aminopeptidase activity
AC611_RS00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC611_RS00175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC611_RS00185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC611_RS00195	COG1064	alcohol dehydrogenase
AC611_RS00210	COG0493	'glutamate synthase
AC611_RS00215	COG0067	glutamate synthase
AC611_RS00215	COG0070	glutamate synthase
AC611_RS00215	COG0069	glutamate synthase activity
AC611_RS00305	COG1205	dead DEAH box helicase
AC611_RS00305	COG1111	helicase
AC611_RS00310	COG1272	protein, Hemolysin III
AC611_RS00330	COG0300	oxidoreductase activity
AC611_RS00335	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS00375	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC611_RS00390	COG3039	Transposase
AC611_RS00405	COG3039	Transposase
AC611_RS00425	COG3237	CsbD-like
AC611_RS00470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC611_RS00480	COG0477	Major facilitator Superfamily
AC611_RS00525	COG0714	Associated with various cellular activities
AC611_RS00570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC611_RS00580	COG4772	TonB-dependent receptor
AC611_RS00610	COG1304	FMN binding
AC611_RS00615	COG1755	Isoprenylcysteine carboxyl methyltransferase
AC611_RS00620	COG4585	Histidine kinase
AC611_RS00625	COG2197	response regulator
AC611_RS00650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC611_RS00655	COG3039	Transposase
AC611_RS00660	COG3039	Transposase
AC611_RS00675	COG0366	Alpha amylase catalytic
AC611_RS00680	COG0366	Alpha amylase catalytic
AC611_RS00685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC611_RS00705	COG0657	acetylesterase activity
AC611_RS00705	COG2755	lipolytic protein G-D-S-L family
AC611_RS00715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC611_RS00730	COG3507	Belongs to the glycosyl hydrolase 43 family
AC611_RS00735	COG1609	Transcriptional regulator
AC611_RS00740	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC611_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS00755	COG2755	lipolytic protein G-D-S-L family
AC611_RS00765	COG3186	Phenylalanine-4-hydroxylase
AC611_RS00770	COG1522	sequence-specific DNA binding
AC611_RS00780	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC611_RS00790	COG1119	ATPase activity
AC611_RS00805	COG0517	IMP dehydrogenase activity
AC611_RS00805	COG1125	glycine betaine transport
AC611_RS00820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC611_RS00855	COG0489	protein tyrosine kinase activity
AC611_RS00860	COG2062	phosphohistidine phosphatase, SixA
AC611_RS00870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC611_RS00910	COG1968	undecaprenyl-diphosphatase activity
AC611_RS00920	COG0174	glutamine synthetase
AC611_RS00925	COG0347	Belongs to the P(II) protein family
AC611_RS00930	COG0004	ammonium transporteR
AC611_RS00935	COG3852	Histidine kinase
AC611_RS00940	COG2204	response regulator
AC611_RS00945	COG2032	superoxide dismutase activity
AC611_RS00950	COG2032	superoxide dismutase activity
AC611_RS00965	COG0183	Belongs to the thiolase family
AC611_RS01000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC611_RS01005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC611_RS01010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC611_RS01040	COG2205	protein histidine kinase activity
AC611_RS01065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC611_RS01080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC611_RS01085	COG3177	Filamentation induced by cAMP protein fic
AC611_RS01090	COG0596	Alpha beta hydrolase
AC611_RS01095	COG0727	PFAM Uncharacterised protein family (UPF0153)
AC611_RS01100	COG0318	PFAM AMP-dependent synthetase and ligase
AC611_RS01105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC611_RS01120	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC611_RS01135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC611_RS01145	COG0564	pseudouridine synthase activity
AC611_RS01170	COG1446	asparaginase
AC611_RS01175	COG0339	signal peptide processing
AC611_RS01210	COG0475	glutathione-regulated potassium exporter activity
AC611_RS01225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC611_RS01230	COG2224	Isocitrate lyase
AC611_RS01250	COG3039	Transposase
AC611_RS01270	COG4770	biotin carboxylase activity
AC611_RS01275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC611_RS01280	COG1960	acyl-CoA dehydrogenase activity
AC611_RS01345	COG0697	spore germination
AC611_RS01355	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC611_RS01360	COG1846	Transcriptional regulator
AC611_RS01365	COG1764	response to oxidative stress
AC611_RS01385	COG2130	NADP-dependent
AC611_RS01400	COG1187	pseudouridine synthase activity
AC611_RS01410	COG1643	Atp-dependent helicase
AC611_RS01425	COG4807	Protein conserved in bacteria
AC611_RS01435	COG2072	flavoprotein involved in K transport
AC611_RS01455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC611_RS01465	COG0583	DNA-binding transcription factor activity
AC611_RS01505	COG2252	PERMEase
AC611_RS01530	COG0084	hydrolase, TatD family'
AC611_RS01545	COG0583	DNA-binding transcription factor activity
AC611_RS01550	COG2814	Major facilitator Superfamily
AC611_RS01565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC611_RS01570	COG1902	pentaerythritol trinitrate reductase activity
AC611_RS01590	COG0745	RESPONSE REGULATOR receiver
AC611_RS01595	COG2205	protein histidine kinase activity
AC611_RS01600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC611_RS01625	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC611_RS01630	COG0583	DNA-binding transcription factor activity
AC611_RS01670	COG0702	epimerase
AC611_RS01675	COG1733	regulation of RNA biosynthetic process
AC611_RS01695	COG3328	transposase activity
AC611_RS01740	COG0129	dihydroxy-acid dehydratase activity
AC611_RS01755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AC611_RS01810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC611_RS01815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AC611_RS01840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC611_RS01855	COG3485	protocatechuate 3,4-dioxygenase
AC611_RS01860	COG3485	protocatechuate 3,4-dioxygenase
AC611_RS01870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC611_RS01875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC611_RS01885	COG1414	Transcriptional regulator
AC611_RS01895	COG0657	acetylesterase activity
AC611_RS01905	COG0445	tRNA wobble uridine modification
AC611_RS01915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC611_RS01950	COG2267	carboxylic ester hydrolase activity
AC611_RS01960	COG0156	8-amino-7-oxononanoate synthase activity
AC611_RS01965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC611_RS01970	COG1040	competence protein
AC611_RS01975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC611_RS02005	COG3039	Transposase
AC611_RS02070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC611_RS02145	COG1511	domain protein
AC611_RS02145	COG3264	Mechanosensitive ion channel
AC611_RS02150	COG1368	sulfuric ester hydrolase activity
AC611_RS02155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC611_RS02160	COG2354	Protein conserved in bacteria
AC611_RS02170	COG0297	glycogen (starch) synthase activity
AC611_RS02175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC611_RS02180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC611_RS02205	COG0702	epimerase
AC611_RS02235	COG3328	transposase activity
AC611_RS02245	COG3039	Transposase
AC611_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS02295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC611_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS02310	COG0513	Belongs to the DEAD box helicase family
AC611_RS02315	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC611_RS02330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC611_RS02340	COG3483	tryptophan 2,3-dioxygenase activity
AC611_RS02345	COG3104	oligopeptide transport
AC611_RS02365	COG2852	Protein conserved in bacteria
AC611_RS02370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AC611_RS02390	COG1320	monovalent cation:proton antiporter activity
AC611_RS02395	COG2212	antiporter activity
AC611_RS02405	COG0651	ATP synthesis coupled electron transport
AC611_RS02410	COG1006	Multisubunit Na H antiporter MnhC subunit
AC611_RS02415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC611_RS02415	COG2111	Na H antiporter
AC611_RS02435	COG3179	chitinase
AC611_RS02455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC611_RS02460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC611_RS02480	COG1597	lipid kinase activity
AC611_RS02505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC611_RS02510	COG0134	indole-3-glycerol-phosphate synthase activity
AC611_RS02520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC611_RS02525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AC611_RS02535	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC611_RS02545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC611_RS02560	COG1051	belongs to the nudix hydrolase family
AC611_RS02600	COG0316	Belongs to the HesB IscA family
AC611_RS02615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC611_RS02630	COG2814	Major facilitator Superfamily
AC611_RS02640	COG2814	Major facilitator Superfamily
AC611_RS02645	COG1289	transmembrane transporter activity
AC611_RS02655	COG0151	Belongs to the GarS family
AC611_RS02665	COG0138	bifunctional purine biosynthesis protein purh
AC611_RS02670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC611_RS02675	COG2267	carboxylic ester hydrolase activity
AC611_RS02680	COG0671	phosphoesterase, PA-phosphatase related
AC611_RS02680	COG2453	phosphatase
AC611_RS02705	COG4589	Belongs to the CDS family
AC611_RS02710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC611_RS02735	COG2264	protein methyltransferase activity
AC611_RS02755	COG0439	Biotin carboxylase
AC611_RS02765	COG0511	ligase activity, forming carbon-carbon bonds
AC611_RS02770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC611_RS02780	COG1324	tolerance protein
AC611_RS02800	COG0459	protein refolding
AC611_RS02815	COG3550	peptidyl-serine autophosphorylation
AC611_RS02820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC611_RS02835	COG3386	PFAM SMP-30 Gluconolaconase
AC611_RS02845	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC611_RS02850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC611_RS02870	COG3039	Transposase
AC611_RS02890	COG0778	Nitroreductase
AC611_RS02895	COG2353	YceI-like domain
AC611_RS02930	COG3052	prosthetic group binding
AC611_RS02955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC611_RS02965	COG1802	Transcriptional regulator
AC611_RS03020	COG3328	transposase activity
AC611_RS03035	COG4221	oxidoreductase activity
AC611_RS03065	COG4221	oxidoreductase activity
AC611_RS03075	COG0435	Glutathione S-transferase
AC611_RS03155	COG1959	2 iron, 2 sulfur cluster binding
AC611_RS03180	COG0697	spore germination
AC611_RS03185	COG4305	rare lipoprotein A
AC611_RS03190	COG5297	Belongs to the glycosyl hydrolase family 6
AC611_RS03200	COG1113	amino acid transport
AC611_RS03210	COG0598	Magnesium transport protein CorA
AC611_RS03255	COG5002	protein histidine kinase activity
AC611_RS03255	COG5001	Diguanylate cyclase
AC611_RS03255	COG3447	MASE1 domain protein
AC611_RS03270	COG0784	Response regulator, receiver
AC611_RS03270	COG2205	protein histidine kinase activity
AC611_RS03335	COG2943	transferase activity, transferring hexosyl groups
AC611_RS03345	COG3275	phosphorelay sensor kinase activity
AC611_RS03355	COG0181	hydroxymethylbilane synthase activity
AC611_RS03395	COG1505	serine-type exopeptidase activity
AC611_RS03405	COG0436	Aminotransferase
AC611_RS03415	COG2832	Protein of unknown function (DUF454)
AC611_RS03425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC611_RS03435	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC611_RS03440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC611_RS03445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC611_RS03475	COG2226	methyltransferase
AC611_RS03480	COG3300	MHYT domain
AC611_RS03480	COG5001	Diguanylate cyclase
AC611_RS03485	COG0308	aminopeptidase N
AC611_RS03535	COG3284	Transcriptional regulator
AC611_RS03550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC611_RS03555	COG1077	Cell shape determining protein MreB Mrl
AC611_RS03560	COG1792	Involved in formation and maintenance of cell shape
AC611_RS03575	COG0772	Belongs to the SEDS family
AC611_RS03590	COG3039	Transposase
AC611_RS03620	COG2951	lytic endotransglycosylase activity
AC611_RS03625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AC611_RS03630	COG1686	Belongs to the peptidase S11 family
AC611_RS03640	COG2921	Belongs to the UPF0250 family
AC611_RS03645	COG0321	lipoyl(octanoyl) transferase activity
AC611_RS03650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC611_RS03675	COG1051	belongs to the nudix hydrolase family
AC611_RS03675	COG1056	cytidyltransferase-related domain
AC611_RS03710	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC611_RS03715	COG0673	inositol 2-dehydrogenase activity
AC611_RS03720	COG2823	Periplasmic or secreted lipoprotein
AC611_RS03725	COG4251	negative regulation of phosphorylation
AC611_RS03730	COG0784	Response regulator, receiver
AC611_RS03735	COG4191	Histidine kinase
AC611_RS03740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC611_RS03795	COG1459	type II secretion system
AC611_RS03840	COG2188	Transcriptional regulator
AC611_RS03850	COG1609	Transcriptional regulator
AC611_RS03855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC611_RS03860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC611_RS03870	COG0617	tRNA 3'-terminal CCA addition
AC611_RS03890	COG0525	valine-tRNA ligase activity
AC611_RS03905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC611_RS03915	COG0795	lipopolysaccharide-transporting ATPase activity
AC611_RS03930	COG4974	Belongs to the 'phage' integrase family
AC611_RS03945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC611_RS03955	COG0047	phosphoribosylformylglycinamidine synthase activity
AC611_RS03955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC611_RS03960	COG5295	Hep Hag repeat protein
AC611_RS03965	COG1404	Belongs to the peptidase S8 family
AC611_RS03970	COG5295	Hep Hag repeat protein
AC611_RS03975	COG1404	Belongs to the peptidase S8 family
AC611_RS03980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC611_RS03990	COG1459	type II secretion system
AC611_RS03995	COG2165	general secretion pathway protein
AC611_RS04000	COG4970	Tfp pilus assembly protein FimT
AC611_RS04005	COG2165	general secretion pathway protein
AC611_RS04010	COG4795	General secretion pathway protein
AC611_RS04015	COG3156	type II secretion system protein K
AC611_RS04020	COG3166	PFAM Fimbrial assembly family protein
AC611_RS04035	COG1450	Type ii and iii secretion system protein
AC611_RS04045	COG2188	Transcriptional regulator
AC611_RS04120	COG1215	transferase activity, transferring glycosyl groups
AC611_RS04125	COG1215	transferase activity, transferring glycosyl groups
AC611_RS04130	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AC611_RS04155	COG0242	peptide deformylase activity
AC611_RS04160	COG0488	(ABC) transporter
AC611_RS04170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC611_RS04175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC611_RS04185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC611_RS04185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC611_RS04195	COG3328	transposase activity
AC611_RS04210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC611_RS04215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC611_RS04220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AC611_RS04240	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AC611_RS04245	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AC611_RS04255	COG2205	protein histidine kinase activity
AC611_RS04260	COG0745	RESPONSE REGULATOR receiver
AC611_RS04270	COG0277	FAD linked oxidase domain protein
AC611_RS04275	COG1988	membrane-bound metal-dependent
AC611_RS04280	COG0792	nuclease activity
AC611_RS04325	COG3116	cell division
AC611_RS04335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC611_RS04340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC611_RS04345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC611_RS04355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC611_RS04360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC611_RS04365	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC611_RS04370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC611_RS04385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC611_RS04395	COG0739	heme binding
AC611_RS04400	COG0653	protein targeting
AC611_RS04405	COG0494	nUDIX hydrolase
AC611_RS04415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC611_RS04425	COG3321	synthase
AC611_RS04425	COG0604	alcohol dehydrogenase
AC611_RS04425	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS04440	COG0366	Alpha amylase catalytic
AC611_RS04475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AC611_RS04480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC611_RS04490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC611_RS04530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC611_RS04540	COG4106	trans-aconitate 2-methyltransferase activity
AC611_RS04545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC611_RS04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC611_RS04565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AC611_RS04570	COG0667	Aldo Keto reductase
AC611_RS04580	COG4771	TonB-dependent receptor
AC611_RS04600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC611_RS04605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AC611_RS04615	COG2175	clavaminate synthase activity
AC611_RS04625	COG4181	ATPase activity
AC611_RS04640	COG0642	Histidine kinase
AC611_RS04650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC611_RS04660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AC611_RS04670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC611_RS04675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC611_RS04690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC611_RS04695	COG2967	ApaG domain
AC611_RS04700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC611_RS04705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC611_RS04710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC611_RS04715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC611_RS04730	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC611_RS04735	COG2096	Adenosyltransferase
AC611_RS04750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC611_RS04755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC611_RS04785	COG3384	dioxygenase
AC611_RS04790	COG0583	DNA-binding transcription factor activity
AC611_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
AC611_RS04805	COG1024	Enoyl-CoA hydratase
AC611_RS04825	COG3386	PFAM SMP-30 Gluconolaconase
AC611_RS04835	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC611_RS04855	COG0697	spore germination
AC611_RS04865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC611_RS04890	COG2197	response regulator
AC611_RS04900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC611_RS04915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC611_RS04920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC611_RS04930	COG0583	DNA-binding transcription factor activity
AC611_RS04935	COG3634	alkyl hydroperoxide reductase activity
AC611_RS04945	COG2890	protein-(glutamine-N5) methyltransferase activity
AC611_RS04965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC611_RS04965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC611_RS05005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC611_RS05020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC611_RS05025	COG1404	Belongs to the peptidase S8 family
AC611_RS05030	COG1404	Belongs to the peptidase S8 family
AC611_RS05035	COG1404	Belongs to the peptidase S8 family
AC611_RS05040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC611_RS05065	COG1295	ribonuclease BN
AC611_RS05070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC611_RS05075	COG1254	Belongs to the acylphosphatase family
AC611_RS05090	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC611_RS05100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC611_RS05105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC611_RS05115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC611_RS05120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC611_RS05130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC611_RS05135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC611_RS05140	COG0193	aminoacyl-tRNA hydrolase activity
AC611_RS05145	COG0012	GTP binding
AC611_RS05165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC611_RS05180	COG0250	Participates in transcription elongation, termination and antitermination
AC611_RS05185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC611_RS05190	COG0081	regulation of translation
AC611_RS05195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC611_RS05205	COG0085	RNA polymerase activity
AC611_RS05210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC611_RS05215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC611_RS05220	COG0049	tRNA binding
AC611_RS05225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC611_RS05230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC611_RS05245	COG3328	transposase activity
AC611_RS05250	COG0051	transcription antitermination factor activity, RNA binding
AC611_RS05255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC611_RS05260	COG0088	Forms part of the polypeptide exit tunnel
AC611_RS05265	COG0089	rRNA binding
AC611_RS05270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC611_RS05275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC611_RS05285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC611_RS05290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC611_RS05295	COG0255	Belongs to the universal ribosomal protein uL29 family
AC611_RS05300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC611_RS05310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC611_RS05315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC611_RS05325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC611_RS05330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC611_RS05335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC611_RS05345	COG1841	ribosomal large subunit assembly
AC611_RS05350	COG0200	Binds to the 23S rRNA
AC611_RS05355	COG0201	protein transport
AC611_RS05380	COG0203	ribosomal protein L17
AC611_RS05385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC611_RS05405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC611_RS05415	COG0154	amidase activity
AC611_RS05425	COG1217	gtp-binding protein TYPA
AC611_RS05430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC611_RS05435	COG0039	L-malate dehydrogenase activity
AC611_RS05440	COG0625	glutathione transferase activity
AC611_RS05460	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC611_RS05460	COG1902	pentaerythritol trinitrate reductase activity
AC611_RS05465	COG0604	alcohol dehydrogenase
AC611_RS05475	COG3328	transposase activity
AC611_RS05480	COG3039	Transposase
AC611_RS05485	COG2885	chlorophyll binding
AC611_RS05505	COG0156	8-amino-7-oxononanoate synthase activity
AC611_RS05510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC611_RS05515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AC611_RS05520	COG4208	sulfate ABC transporter
AC611_RS05525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC611_RS05535	COG3328	transposase activity
AC611_RS05560	COG0406	alpha-ribazole phosphatase activity
AC611_RS05570	COG0285	dihydrofolate synthase activity
AC611_RS05590	COG2833	Protein of unknown function (DUF455)
AC611_RS05610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC611_RS05615	COG0671	phosphoesterase, PA-phosphatase related
AC611_RS05620	COG0438	transferase activity, transferring glycosyl groups
AC611_RS05630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC611_RS05645	COG4783	chaperone-mediated protein folding
AC611_RS05660	COG0473	3-isopropylmalate dehydrogenase activity
AC611_RS05700	COG3328	transposase activity
AC611_RS05715	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC611_RS05725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC611_RS05755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC611_RS05765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC611_RS05775	COG0328	RNA-DNA hybrid ribonuclease activity
AC611_RS05780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC611_RS05785	COG0631	protein serine/threonine phosphatase activity
AC611_RS05810	COG0859	PFAM glycosyl transferase family 9
AC611_RS05815	COG3642	lipopolysaccharide core region biosynthetic process
AC611_RS05820	COG1234	tRNA 3'-trailer cleavage
AC611_RS05825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC611_RS05835	COG0315	cyclic pyranopterin monophosphate synthase activity
AC611_RS05840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC611_RS05845	COG0314	molybdopterin synthase activity
AC611_RS05865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC611_RS05870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC611_RS05875	COG0537	adenosine 5'-monophosphoramidase activity
AC611_RS05895	COG0714	Associated with various cellular activities
AC611_RS05910	COG0424	maF-like protein
AC611_RS05915	COG1399	metal-binding, possibly nucleic acid-binding protein
AC611_RS05920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AC611_RS05925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC611_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS05955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AC611_RS05960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC611_RS05995	COG3829	transcription factor binding
AC611_RS06045	COG2373	Large extracellular alpha-helical protein
AC611_RS06070	COG3852	Histidine kinase
AC611_RS06075	COG4953	penicillin-binding protein 1C
AC611_RS06085	COG0678	peroxiredoxin activity
AC611_RS06105	COG0330	HflC and HflK could
AC611_RS06110	COG0330	HflC and HflK could
AC611_RS06120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC611_RS06125	COG0308	aminopeptidase N
AC611_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS06140	COG1309	transcriptional regulator
AC611_RS06200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC611_RS06210	COG3387	PFAM Glycoside hydrolase 15-related
AC611_RS06225	COG3537	Alpha-1,2-mannosidase
AC611_RS06250	COG0492	ferredoxin-NADP+ reductase activity
AC611_RS06280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC611_RS06285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC611_RS06290	COG2080	2 iron, 2 sulfur cluster binding
AC611_RS06325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC611_RS06340	COG0587	DNA-directed DNA polymerase activity
AC611_RS06360	COG1297	OPT oligopeptide transporter protein
AC611_RS06395	COG0823	Involved in the tonB-independent uptake of proteins
AC611_RS06395	COG1506	peptidase
AC611_RS06435	COG1917	Cupin 2, conserved barrel domain protein
AC611_RS06435	COG2207	Transcriptional regulator
AC611_RS06450	COG3328	transposase activity
AC611_RS06465	COG0753	catalase activity
AC611_RS06470	COG0656	L-ascorbic acid biosynthetic process
AC611_RS06480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC611_RS06480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC611_RS06505	COG2814	Major facilitator Superfamily
AC611_RS06530	COG2963	transposase activity
AC611_RS06540	COG2194	sulfuric ester hydrolase activity
AC611_RS06555	COG0745	RESPONSE REGULATOR receiver
AC611_RS06560	COG0642	Histidine kinase
AC611_RS06570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC611_RS06575	COG2894	cell division
AC611_RS06580	COG0850	regulation of cytokinetic process
AC611_RS06595	COG4585	Histidine kinase
AC611_RS06600	COG2197	response regulator
AC611_RS06615	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC611_RS06645	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC611_RS06655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC611_RS06670	COG1595	DNA-templated transcription, initiation
AC611_RS06680	COG1946	Acyl-CoA thioesterase
AC611_RS06695	COG0824	Thioesterase
AC611_RS06700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC611_RS06705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC611_RS06710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC611_RS06715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC611_RS06720	COG0268	Binds directly to 16S ribosomal RNA
AC611_RS06730	COG0196	riboflavin kinase activity
AC611_RS06735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC611_RS06740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC611_RS06745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC611_RS06855	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AC611_RS06855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC611_RS06890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC611_RS06895	COG1845	cytochrome c oxidase, subunit III
AC611_RS06900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AC611_RS06915	COG3152	Membrane
AC611_RS06925	COG2207	Transcriptional regulator
AC611_RS06930	COG0326	Molecular chaperone. Has ATPase activity
AC611_RS06940	COG1366	Belongs to the anti-sigma-factor antagonist family
AC611_RS06945	COG1366	Belongs to the anti-sigma-factor antagonist family
AC611_RS06975	COG4771	TonB-dependent receptor
AC611_RS06985	COG5507	3-demethylubiquinone-9 3-methyltransferase
AC611_RS06990	COG2205	protein histidine kinase activity
AC611_RS07000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC611_RS07005	COG3437	response regulator, receiver
AC611_RS07005	COG3850	Histidine kinase
AC611_RS07005	COG4999	Histidine kinase
AC611_RS07005	COG2205	protein histidine kinase activity
AC611_RS07010	COG0784	Response regulator, receiver
AC611_RS07010	COG4191	Histidine kinase
AC611_RS07035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC611_RS07045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC611_RS07050	COG0228	four-way junction DNA binding
AC611_RS07055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC611_RS07060	COG0336	Belongs to the RNA methyltransferase TrmD family
AC611_RS07065	COG0335	large ribosomal subunit rRNA binding
AC611_RS07070	COG0534	Mate efflux family protein
AC611_RS07095	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC611_RS07110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC611_RS07150	COG3250	beta-galactosidase activity
AC611_RS07155	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AC611_RS07175	COG1960	acyl-CoA dehydrogenase activity
AC611_RS07205	COG0457	Tetratricopeptide repeat
AC611_RS07215	COG0457	Tetratricopeptide repeat
AC611_RS07225	COG1024	Enoyl-CoA hydratase
AC611_RS07225	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC611_RS07240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC611_RS07250	COG0481	GTPase activity
AC611_RS07265	COG0571	ribonuclease III activity
AC611_RS07270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC611_RS07275	COG1381	Involved in DNA repair and RecF pathway recombination
AC611_RS07285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC611_RS07290	COG2954	triphosphatase activity
AC611_RS07295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC611_RS07300	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC611_RS07305	COG3046	protein related to deoxyribodipyrimidine photolyase
AC611_RS07310	COG1472	Belongs to the glycosyl hydrolase 3 family
AC611_RS07315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AC611_RS07320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AC611_RS07325	COG1278	Cold shock
AC611_RS07330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC611_RS07340	COG1201	RNA secondary structure unwinding
AC611_RS07345	COG1793	dna ligase
AC611_RS07355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC611_RS07355	COG1793	dna ligase
AC611_RS07395	COG0183	Belongs to the thiolase family
AC611_RS07415	COG1451	nucleotide metabolic process
AC611_RS07420	COG5487	UPF0391 membrane protein
AC611_RS07430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC611_RS07450	COG1077	Cell shape determining protein MreB Mrl
AC611_RS07455	COG1047	Peptidyl-prolyl cis-trans
AC611_RS07465	COG2824	Alkylphosphonate utilization operon protein PhnA
AC611_RS07475	COG1902	pentaerythritol trinitrate reductase activity
AC611_RS07480	COG2814	Major facilitator Superfamily
AC611_RS07515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AC611_RS07515	COG0392	lysyltransferase activity
AC611_RS07525	COG0251	oxidation-reduction process
AC611_RS07530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC611_RS07545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC611_RS07570	COG1595	DNA-templated transcription, initiation
AC611_RS07585	COG2878	Part of a membrane complex involved in electron transport
AC611_RS07600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC611_RS07600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC611_RS07625	COG0346	lactoylglutathione lyase activity
AC611_RS07640	COG0833	amino acid
AC611_RS07645	COG2040	homocysteine
AC611_RS07655	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC611_RS07675	COG1695	Transcriptional regulator
AC611_RS07695	COG1981	membrane
AC611_RS07710	COG0825	malonyl-CoA metabolic process
AC611_RS07725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC611_RS07730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC611_RS07735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC611_RS07740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC611_RS07755	COG0750	zinc metalloprotease
AC611_RS07760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC611_RS07765	COG0575	Belongs to the CDS family
AC611_RS07770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC611_RS07775	COG0233	cytoplasmic translational termination
AC611_RS07780	COG0528	UMP kinase activity
AC611_RS07790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC611_RS07795	COG0052	Belongs to the universal ribosomal protein uS2 family
AC611_RS07835	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC611_RS07845	COG1393	Belongs to the ArsC family
AC611_RS07850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC611_RS07855	COG0367	asparagine synthase
AC611_RS07865	COG4774	siderophore transport
AC611_RS07925	COG3328	transposase activity
AC611_RS07960	COG1566	PFAM secretion protein HlyD family protein
AC611_RS07965	COG2814	Major facilitator Superfamily
AC611_RS07995	COG3104	oligopeptide transport
AC611_RS08025	COG0339	signal peptide processing
AC611_RS08030	COG0386	Belongs to the glutathione peroxidase family
AC611_RS08090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC611_RS08095	COG0084	hydrolase, TatD family'
AC611_RS08110	COG1960	acyl-CoA dehydrogenase activity
AC611_RS08130	COG0367	asparagine synthase
AC611_RS08140	COG0305	Participates in initiation and elongation during chromosome replication
AC611_RS08145	COG0415	Belongs to the DNA photolyase family
AC611_RS08165	COG0583	DNA-binding transcription factor activity
AC611_RS08210	COG3706	GGDEF domain
AC611_RS08230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC611_RS08245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC611_RS08255	COG0497	DNA recombination
AC611_RS08260	COG1420	regulation of RNA biosynthetic process
AC611_RS08265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC611_RS08270	COG0443	Heat shock 70 kDa protein
AC611_RS08275	COG0484	heat shock protein binding
AC611_RS08280	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AC611_RS08310	COG0583	DNA-binding transcription factor activity
AC611_RS08320	COG1132	(ABC) transporter
AC611_RS08355	COG2850	peptidyl-arginine hydroxylation
AC611_RS08375	COG1253	flavin adenine dinucleotide binding
AC611_RS08410	COG1131	(ABC) transporter
AC611_RS08415	COG1725	Transcriptional regulator
AC611_RS08425	COG0386	Belongs to the glutathione peroxidase family
AC611_RS08435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AC611_RS08445	COG2900	Belongs to the SlyX family
AC611_RS08475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC611_RS08485	COG1410	methionine synthase
AC611_RS08485	COG0646	methionine synthase
AC611_RS08490	COG1410	methionine synthase
AC611_RS08490	COG0646	methionine synthase
AC611_RS08495	COG2226	methyltransferase
AC611_RS08500	COG1960	acyl-CoA dehydrogenase activity
AC611_RS08505	COG1960	acyl-CoA dehydrogenase activity
AC611_RS08520	COG0557	exoribonuclease II activity
AC611_RS08530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC611_RS08545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC611_RS08555	COG0704	Plays a role in the regulation of phosphate uptake
AC611_RS08560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC611_RS08565	COG0581	inorganic phosphate transmembrane transporter activity
AC611_RS08570	COG0573	inorganic phosphate transmembrane transporter activity
AC611_RS08575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC611_RS08600	COG0659	secondary active sulfate transmembrane transporter activity
AC611_RS08605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC611_RS08615	COG1024	Enoyl-CoA hydratase
AC611_RS08625	COG0494	nUDIX hydrolase
AC611_RS08660	COG0488	(ABC) transporter
AC611_RS08670	COG0116	Belongs to the methyltransferase superfamily
AC611_RS08670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC611_RS08675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC611_RS08695	COG2925	Exonuclease
AC611_RS08705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC611_RS08710	COG3844	kynureninase activity
AC611_RS08720	COG0662	Cupin 2, conserved barrel domain protein
AC611_RS08725	COG0288	reversible hydration of carbon dioxide
AC611_RS08805	COG0017	Asparaginyl-tRNA synthetase
AC611_RS08815	COG0316	Belongs to the HesB IscA family
AC611_RS08820	COG0360	Binds together with S18 to 16S ribosomal RNA
AC611_RS08825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC611_RS08830	COG0359	binds to the 23S rRNA
AC611_RS08840	COG3115	cell septum assembly
AC611_RS08850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC611_RS08855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC611_RS08860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AC611_RS08875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC611_RS08885	COG4993	Dehydrogenase
AC611_RS08895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC611_RS08905	COG2986	histidine ammonia-lyase
AC611_RS08910	COG1228	amidohydrolase
AC611_RS08950	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC611_RS08955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC611_RS08960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC611_RS08965	COG0077	Prephenate dehydratase
AC611_RS08965	COG1605	Chorismate mutase
AC611_RS08970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC611_RS08985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC611_RS08990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC611_RS08995	COG0583	DNA-binding transcription factor activity
AC611_RS09055	COG0784	Response regulator, receiver
AC611_RS09055	COG4191	Histidine kinase
AC611_RS09065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AC611_RS09085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC611_RS09095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC611_RS09105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC611_RS09120	COG1595	DNA-templated transcription, initiation
AC611_RS09175	COG2244	polysaccharide biosynthetic process
AC611_RS09205	COG2264	protein methyltransferase activity
AC611_RS09230	COG1136	(ABC) transporter
AC611_RS09240	COG0477	Major facilitator Superfamily
AC611_RS09245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC611_RS09260	COG1253	flavin adenine dinucleotide binding
AC611_RS09275	COG0306	phosphate transporter
AC611_RS09300	COG0504	CTP synthase activity
AC611_RS09305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AC611_RS09315	COG0148	phosphopyruvate hydratase activity
AC611_RS09320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC611_RS09330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC611_RS09335	COG0585	pseudouridine synthase activity
AC611_RS09340	COG2840	Smr protein MutS2
AC611_RS09345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC611_RS09350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC611_RS09355	COG1238	metal cluster binding
AC611_RS09365	COG3737	Protein of unknown function (DUF498/DUF598)
AC611_RS09370	COG1534	Rna-binding protein
AC611_RS09375	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC611_RS09385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC611_RS09390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC611_RS09400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC611_RS09405	COG1546	Belongs to the CinA family
AC611_RS09415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC611_RS09420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC611_RS09430	COG2137	regulation of response to DNA damage stimulus
AC611_RS09435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC611_RS09440	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AC611_RS09460	COG0583	DNA-binding transcription factor activity
AC611_RS09485	COG0351	phosphomethylpyrimidine kinase
AC611_RS09500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC611_RS09505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC611_RS09520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC611_RS09530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC611_RS09535	COG3734	2-keto-3-deoxy-galactonokinase
AC611_RS09545	COG4948	Mandelate Racemase Muconate Lactonizing
AC611_RS09550	COG0800	Aldolase
AC611_RS09590	COG1501	Belongs to the glycosyl hydrolase 31 family
AC611_RS09600	COG1070	Carbohydrate kinase
AC611_RS09605	COG2115	Belongs to the xylose isomerase family
AC611_RS09610	COG0477	Major facilitator Superfamily
AC611_RS09620	COG3328	transposase activity
AC611_RS09640	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC611_RS09645	COG1469	GTP cyclohydrolase I activity
AC611_RS09670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC611_RS09675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC611_RS09680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC611_RS09685	COG0166	Belongs to the GPI family
AC611_RS09705	COG1472	Belongs to the glycosyl hydrolase 3 family
AC611_RS09720	COG5001	Diguanylate cyclase
AC611_RS09720	COG3706	GGDEF domain
AC611_RS09720	COG2203	Gaf domain
AC611_RS09720	COG4251	negative regulation of phosphorylation
AC611_RS09725	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC611_RS09730	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AC611_RS09745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC611_RS09750	COG0671	phosphoesterase, PA-phosphatase related
AC611_RS09760	COG1794	racemase activity, acting on amino acids and derivatives
AC611_RS09770	COG0697	spore germination
AC611_RS09775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC611_RS09780	COG0167	dihydroorotate dehydrogenase activity
AC611_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
AC611_RS09820	COG3328	transposase activity
AC611_RS09835	COG0366	Alpha amylase catalytic
AC611_RS09855	COG1082	Xylose isomerase domain protein TIM barrel
AC611_RS09865	COG2211	Major facilitator Superfamily
AC611_RS09880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC611_RS09885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC611_RS09900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC611_RS09905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC611_RS09905	COG0072	phenylalanine-tRNA ligase activity
AC611_RS09955	COG0438	transferase activity, transferring glycosyl groups
AC611_RS09960	COG0438	transferase activity, transferring glycosyl groups
AC611_RS09970	COG0438	transferase activity, transferring glycosyl groups
AC611_RS09995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC611_RS10005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC611_RS10025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC611_RS10035	COG1960	acyl-CoA dehydrogenase activity
AC611_RS10045	COG3040	lipid binding
AC611_RS10060	COG0322	excinuclease ABC activity
AC611_RS10075	COG4191	Histidine kinase
AC611_RS10075	COG0784	Response regulator, receiver
AC611_RS10095	COG1194	a g-specific adenine glycosylase
AC611_RS10105	COG0552	protein localization to endoplasmic reticulum
AC611_RS10115	COG3938	Belongs to the proline racemase family
AC611_RS10120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC611_RS10135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC611_RS10145	COG0006	proline dipeptidase activity
AC611_RS10165	COG0531	amino acid
AC611_RS10305	COG3328	transposase activity
AC611_RS10340	COG3328	transposase activity
AC611_RS10365	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AC611_RS10370	COG3328	transposase activity
AC611_RS10375	COG0527	aspartate kinase activity
AC611_RS10375	COG0460	homoserine dehydrogenase
AC611_RS10410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC611_RS10415	COG0124	histidyl-tRNA synthetase
AC611_RS10425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC611_RS10430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC611_RS10435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC611_RS10440	COG0131	Imidazoleglycerol-phosphate dehydratase
AC611_RS10440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC611_RS10445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC611_RS10450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC611_RS10455	COG0107	imidazoleglycerol-phosphate synthase activity
AC611_RS10460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC611_RS10460	COG0140	phosphoribosyl-ATP diphosphatase activity
AC611_RS10475	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AC611_RS10480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AC611_RS10485	COG0235	Class ii aldolase
AC611_RS10490	COG0531	amino acid
AC611_RS10495	COG0531	amino acid
AC611_RS10505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC611_RS10510	COG0277	FAD linked oxidase domain protein
AC611_RS10530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC611_RS10575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC611_RS10580	COG2258	MOSC domain
AC611_RS10585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC611_RS10590	COG0505	Belongs to the CarA family
AC611_RS10600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC611_RS10605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC611_RS10615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AC611_RS10635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC611_RS10645	COG2198	Histidine kinase
AC611_RS10645	COG2205	protein histidine kinase activity
AC611_RS10645	COG0784	Response regulator, receiver
AC611_RS10650	COG0784	Response regulator, receiver
AC611_RS10650	COG2198	Histidine kinase
AC611_RS10650	COG2205	protein histidine kinase activity
AC611_RS10655	COG1024	Enoyl-CoA hydratase
AC611_RS10660	COG0318	PFAM AMP-dependent synthetase and ligase
AC611_RS10695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC611_RS10705	COG2201	protein-glutamate methylesterase activity
AC611_RS10710	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC611_RS10720	COG0840	transmembrane signaling receptor activity
AC611_RS10730	COG0835	chemotaxis
AC611_RS10745	COG0840	transmembrane signaling receptor activity
AC611_RS10750	COG0840	transmembrane signaling receptor activity
AC611_RS10755	COG0840	transmembrane signaling receptor activity
AC611_RS10760	COG0840	transmembrane signaling receptor activity
AC611_RS10765	COG0840	transmembrane signaling receptor activity
AC611_RS10780	COG0840	transmembrane signaling receptor activity
AC611_RS10785	COG0840	transmembrane signaling receptor activity
AC611_RS10790	COG0840	transmembrane signaling receptor activity
AC611_RS10795	COG0840	transmembrane signaling receptor activity
AC611_RS10810	COG0840	transmembrane signaling receptor activity
AC611_RS10825	COG0840	transmembrane signaling receptor activity
AC611_RS10830	COG0840	transmembrane signaling receptor activity
AC611_RS10840	COG0745	RESPONSE REGULATOR receiver
AC611_RS10850	COG0835	chemotaxis
AC611_RS10855	COG1192	Involved in chromosome partitioning
AC611_RS10860	COG1360	Flagellar Motor Protein
AC611_RS10865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC611_RS10910	COG0643	Histidine kinase
AC611_RS10910	COG2198	Histidine kinase
AC611_RS10910	COG0784	Response regulator, receiver
AC611_RS10940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC611_RS10965	COG3039	Transposase
AC611_RS10975	COG1684	flagellar biosynthetic protein fliR
AC611_RS10990	COG3039	Transposase
AC611_RS11000	COG3190	flagellar
AC611_RS11050	COG1677	Flagellar hook-basal body complex protein FliE
AC611_RS11075	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC611_RS11085	COG3039	Transposase
AC611_RS11090	COG3328	transposase activity
AC611_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS11125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC611_RS11145	COG2201	protein-glutamate methylesterase activity
AC611_RS11175	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AC611_RS11185	COG3039	Transposase
AC611_RS11190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AC611_RS11200	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC611_RS11200	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC611_RS11205	COG1706	bacterial-type flagellum-dependent cell motility
AC611_RS11210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC611_RS11235	COG4787	bacterial-type flagellum-dependent cell motility
AC611_RS11245	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC611_RS11250	COG1558	bacterial-type flagellum-dependent cell motility
AC611_RS11260	COG0784	Response regulator, receiver
AC611_RS11260	COG0835	chemotaxis
AC611_RS11280	COG5002	protein histidine kinase activity
AC611_RS11290	COG4585	Histidine kinase
AC611_RS11310	COG2915	High frequency lysogenization protein hflD homolog
AC611_RS11315	COG0482	sulfurtransferase activity
AC611_RS11330	COG0542	response to heat
AC611_RS11340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC611_RS11350	COG0492	ferredoxin-NADP+ reductase activity
AC611_RS11355	COG1674	ftsk spoiiie
AC611_RS11365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC611_RS11380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC611_RS11385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC611_RS11390	COG0183	Belongs to the thiolase family
AC611_RS11395	COG1024	Enoyl-CoA hydratase
AC611_RS11395	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC611_RS11430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC611_RS11435	COG1160	GTP binding
AC611_RS11440	COG0303	'Molybdopterin
AC611_RS11445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC611_RS11485	COG0708	Exodeoxyribonuclease III
AC611_RS11495	COG0303	'Molybdopterin
AC611_RS11500	COG0746	molybdenum cofactor guanylyltransferase activity
AC611_RS11525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC611_RS11525	COG1648	precorrin-2 dehydrogenase activity
AC611_RS11535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC611_RS11545	COG2223	nitrite transmembrane transporter activity
AC611_RS11550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC611_RS11560	COG0243	molybdopterin cofactor binding
AC611_RS11575	COG3685	Protein conserved in bacteria
AC611_RS11595	COG5001	Diguanylate cyclase
AC611_RS11605	COG4566	intracellular signal transduction
AC611_RS11660	COG3328	transposase activity
AC611_RS11670	COG3039	Transposase
AC611_RS11675	COG3328	transposase activity
AC611_RS11750	COG3328	transposase activity
AC611_RS11760	COG1073	alpha beta
AC611_RS11760	COG2226	methyltransferase
AC611_RS11775	COG0363	glucosamine-6-phosphate deaminase activity
AC611_RS11795	COG3328	transposase activity
AC611_RS11870	COG3328	transposase activity
AC611_RS11885	COG1192	Involved in chromosome partitioning
AC611_RS11930	COG3012	SEC-C Motif Domain Protein
AC611_RS11930	COG3318	Belongs to the UPF0149 family
AC611_RS11970	COG3328	transposase activity
AC611_RS12000	COG1309	transcriptional regulator
AC611_RS12015	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC611_RS12025	COG0428	transporter
AC611_RS12030	COG3064	Membrane
AC611_RS12040	COG1530	ribonuclease E activity
AC611_RS12045	COG3039	Transposase
AC611_RS12055	COG1054	Belongs to the UPF0176 family
AC611_RS12075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC611_RS12100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC611_RS12105	COG0322	excinuclease ABC activity
AC611_RS12115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC611_RS12120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC611_RS12125	COG1663	tetraacyldisaccharide 4'-kinase activity
AC611_RS12130	COG1132	(ABC) transporter
AC611_RS12140	COG0811	peptide transport
AC611_RS12155	COG1136	(ABC) transporter
AC611_RS12160	COG4591	ABC-type transport system involved in lipoprotein release permease component
AC611_RS12170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC611_RS12175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC611_RS12190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AC611_RS12205	COG0354	folic acid binding
AC611_RS12215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC611_RS12220	COG0837	glucose binding
AC611_RS12225	COG0363	glucosamine-6-phosphate deaminase activity
AC611_RS12230	COG0129	dihydroxy-acid dehydratase activity
AC611_RS12235	COG0800	Aldolase
AC611_RS12310	COG2205	protein histidine kinase activity
AC611_RS12310	COG0784	Response regulator, receiver
AC611_RS12315	COG2183	response to ionizing radiation
AC611_RS12325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC611_RS12325	COG0723	plastoquinol--plastocyanin reductase activity
AC611_RS12340	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC611_RS12350	COG1183	phosphatidylcholine synthase activity
AC611_RS12355	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS12370	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC611_RS12385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC611_RS12400	COG1914	H( )-stimulated, divalent metal cation uptake system
AC611_RS12420	COG2814	Major facilitator Superfamily
AC611_RS12435	COG1335	isochorismatase
AC611_RS12450	COG2197	response regulator
AC611_RS12480	COG0583	DNA-binding transcription factor activity
AC611_RS12485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC611_RS12490	COG3002	Belongs to the UPF0753 family
AC611_RS12500	COG0604	alcohol dehydrogenase
AC611_RS12505	COG3384	dioxygenase
AC611_RS12520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AC611_RS12575	COG0519	Catalyzes the synthesis of GMP from XMP
AC611_RS12575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC611_RS12585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC611_RS12600	COG0475	glutathione-regulated potassium exporter activity
AC611_RS12600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC611_RS12605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC611_RS12615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC611_RS12620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC611_RS12630	COG0776	regulation of translation
AC611_RS12635	COG0539	negative regulation of cytoplasmic translation
AC611_RS12640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AC611_RS12655	COG2957	Belongs to the agmatine deiminase family
AC611_RS12660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC611_RS12685	COG0395	ABC-type sugar transport system, permease component
AC611_RS12690	COG1175	transmembrane transport
AC611_RS12720	COG2350	Protein conserved in bacteria
AC611_RS12725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC611_RS12730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC611_RS12735	COG1187	pseudouridine synthase activity
AC611_RS12750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC611_RS12755	COG0436	Aminotransferase
AC611_RS12760	COG4133	protoheme IX ABC transporter activity
AC611_RS12780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC611_RS12810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC611_RS12820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AC611_RS12825	COG4988	ABC transporter
AC611_RS12835	COG1294	oxidase, subunit
AC611_RS12865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC611_RS12870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC611_RS12880	COG0165	Argininosuccinate lyase
AC611_RS12885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC611_RS12895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC611_RS12900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC611_RS12910	COG0137	argininosuccinate synthase activity
AC611_RS12915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC611_RS12925	COG0215	cysteine-tRNA ligase activity
AC611_RS12930	COG2166	iron-sulfur cluster assembly
AC611_RS12945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC611_RS12950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC611_RS12980	COG4302	ethanolamine ammonia-lyase activity
AC611_RS13010	COG3039	Transposase
AC611_RS13045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC611_RS13050	COG0402	S-adenosylhomocysteine deaminase activity
AC611_RS13060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC611_RS13065	COG1509	lysine 2,3-aminomutase activity
AC611_RS13070	COG5001	Diguanylate cyclase
AC611_RS13070	COG3300	MHYT domain
AC611_RS13085	COG0483	inositol monophosphate 1-phosphatase activity
AC611_RS13090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC611_RS13105	COG0488	(ABC) transporter
AC611_RS13110	COG0513	Belongs to the DEAD box helicase family
AC611_RS13115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC611_RS13120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC611_RS13145	COG0625	glutathione transferase activity
AC611_RS13160	COG4681	YaeQ
AC611_RS13165	COG2081	HI0933 family
AC611_RS13175	COG0501	Belongs to the peptidase M48B family
AC611_RS13180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC611_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS13210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AC611_RS13215	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC611_RS13220	COG0802	atpase or kinase
AC611_RS13225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC611_RS13225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC611_RS13230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC611_RS13235	COG1570	exodeoxyribonuclease VII activity
AC611_RS13250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC611_RS13295	COG0835	chemotaxis
AC611_RS13300	COG0840	transmembrane signaling receptor activity
AC611_RS13305	COG2094	Belongs to the DNA glycosylase MPG family
AC611_RS13310	COG1201	RNA secondary structure unwinding
AC611_RS13330	COG2969	positive regulation of protein catabolic process
AC611_RS13335	COG0625	glutathione transferase activity
AC611_RS13340	COG2857	Cytochrome c1
AC611_RS13345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC611_RS13350	COG0723	plastoquinol--plastocyanin reductase activity
AC611_RS13360	COG0741	lytic transglycosylase activity
AC611_RS13375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC611_RS13380	COG1702	phosphate starvation-inducible protein PhoH
AC611_RS13390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC611_RS13400	COG4535	Mg2 and Co2 transporter CorC
AC611_RS13415	COG1012	belongs to the aldehyde dehydrogenase family
AC611_RS13420	COG1177	transmembrane transport
AC611_RS13425	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC611_RS13430	COG3842	ATPase activity
AC611_RS13450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AC611_RS13465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC611_RS13470	COG0174	glutamine synthetase
AC611_RS13475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC611_RS13485	COG2703	oxygen carrier activity
AC611_RS13490	COG0477	Major facilitator Superfamily
AC611_RS13500	COG0243	molybdopterin cofactor binding
AC611_RS13505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC611_RS13510	COG2223	nitrite transmembrane transporter activity
AC611_RS13525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC611_RS13535	COG2733	membrane
AC611_RS13540	COG5002	protein histidine kinase activity
AC611_RS13540	COG0784	Response regulator, receiver
AC611_RS13540	COG2205	protein histidine kinase activity
AC611_RS13550	COG0477	Major facilitator Superfamily
AC611_RS13555	COG0840	transmembrane signaling receptor activity
AC611_RS13585	COG2902	Dehydrogenase
AC611_RS13595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC611_RS13600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC611_RS13605	COG1609	Transcriptional regulator
AC611_RS13610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC611_RS13610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC611_RS13615	COG1105	Belongs to the carbohydrate kinase PfkB family
AC611_RS13620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC611_RS13620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC611_RS13635	COG3328	transposase activity
AC611_RS13645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC611_RS13655	COG1862	Preprotein translocase
AC611_RS13660	COG0343	queuine tRNA-ribosyltransferase activity
AC611_RS13665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC611_RS13705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC611_RS13710	COG3291	Pkd domain containing protein
AC611_RS13715	COG0405	Gamma-glutamyltransferase
AC611_RS13720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC611_RS13735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC611_RS13740	COG0742	ribosomal rna small subunit methyltransferase
AC611_RS13745	COG0326	Molecular chaperone. Has ATPase activity
AC611_RS13870	COG3702	type iv secretory pathway
AC611_RS13890	COG2948	multi-organism process
AC611_RS13910	COG3505	Type IV secretory pathway VirD4
AC611_RS13925	COG0556	nucleotide-excision repair
AC611_RS14105	COG3179	chitinase
AC611_RS14150	COG4695	Portal protein
AC611_RS14215	COG3328	transposase activity
AC611_RS14235	COG3275	phosphorelay sensor kinase activity
AC611_RS14240	COG1611	Belongs to the LOG family
AC611_RS14255	COG2095	MarC family integral membrane protein
AC611_RS14265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC611_RS14300	COG1185	polyribonucleotide nucleotidyltransferase activity
AC611_RS14305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC611_RS14310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC611_RS14315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC611_RS14320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC611_RS14325	COG0195	Participates in both transcription termination and antitermination
AC611_RS14330	COG0779	Required for maturation of 30S ribosomal subunits
AC611_RS14340	COG1007	ATP synthesis coupled electron transport
AC611_RS14365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC611_RS14370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC611_RS14380	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC611_RS14385	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC611_RS14390	COG0649	NAD binding
AC611_RS14395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC611_RS14400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC611_RS14405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC611_RS14420	COG0149	triose-phosphate isomerase activity
AC611_RS14425	COG4221	oxidoreductase activity
AC611_RS14455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC611_RS14460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC611_RS14465	COG0159	tryptophan synthase activity
AC611_RS14475	COG0133	tryptophan synthase activity
AC611_RS14485	COG0135	phosphoribosylanthranilate isomerase activity
AC611_RS14490	COG0101	tRNA pseudouridine synthase activity
AC611_RS14505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC611_RS14510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC611_RS14515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC611_RS14520	COG2890	protein-(glutamine-N5) methyltransferase activity
AC611_RS14530	COG0688	phosphatidylethanolamine metabolic process
AC611_RS14545	COG0433	COG0433 Predicted ATPase
AC611_RS14570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC611_RS14575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC611_RS14600	COG0717	Belongs to the dCTP deaminase family
AC611_RS14610	COG0489	protein tyrosine kinase activity
AC611_RS14650	COG3590	peptidase
AC611_RS14675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC611_RS14680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC611_RS14685	COG2311	Membrane
AC611_RS14690	COG1047	Peptidyl-prolyl cis-trans
AC611_RS14695	COG0791	NLP P60 protein
AC611_RS14700	COG0791	NLP P60 protein
AC611_RS14710	COG4106	trans-aconitate 2-methyltransferase activity
AC611_RS14715	COG1301	dicarboxylic acid transport
AC611_RS14720	COG1785	Belongs to the alkaline phosphatase family
AC611_RS14730	COG0037	tRNA processing
AC611_RS14735	COG1722	exodeoxyribonuclease VII activity
AC611_RS14740	COG0142	geranyltranstransferase activity
AC611_RS14745	COG4104	PAAR repeat-containing protein
AC611_RS14755	COG0312	modulator of DNA gyrase
AC611_RS14760	COG3028	Belongs to the UPF0307 family
AC611_RS14765	COG0312	modulator of DNA gyrase
AC611_RS14775	COG3164	Protein of unknown function
AC611_RS14785	COG0424	maF-like protein
AC611_RS14790	COG2968	Membrane
AC611_RS14805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC611_RS14820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC611_RS14840	COG0495	leucyl-tRNA aminoacylation
AC611_RS14850	COG3118	belongs to the thioredoxin family
AC611_RS14875	COG2155	Conserved Protein
AC611_RS14925	COG1132	(ABC) transporter
AC611_RS14955	COG0745	RESPONSE REGULATOR receiver
AC611_RS14960	COG5000	phosphorelay sensor kinase activity
AC611_RS14960	COG5002	protein histidine kinase activity
AC611_RS14965	COG0475	glutathione-regulated potassium exporter activity
AC611_RS14975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC611_RS14995	COG1187	pseudouridine synthase activity
AC611_RS15000	COG5002	protein histidine kinase activity
AC611_RS15000	COG5001	Diguanylate cyclase
AC611_RS15010	COG1595	DNA-templated transcription, initiation
AC611_RS15130	COG0667	Aldo Keto reductase
AC611_RS15135	COG2814	Major facilitator Superfamily
AC611_RS15140	COG0583	DNA-binding transcription factor activity
AC611_RS15150	COG2207	Transcriptional regulator
AC611_RS15160	COG1309	transcriptional regulator
AC611_RS15170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC611_RS15185	COG0735	belongs to the Fur family
AC611_RS15190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC611_RS15215	COG4452	Inner membrane protein CreD
AC611_RS15235	COG0745	RESPONSE REGULATOR receiver
AC611_RS15240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC611_RS15250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC611_RS15260	COG2198	Histidine kinase
AC611_RS15260	COG0643	Histidine kinase
AC611_RS15265	COG0840	transmembrane signaling receptor activity
AC611_RS15270	COG0835	chemotaxis
AC611_RS15275	COG2202	Pas domain
AC611_RS15275	COG2200	EAL domain
AC611_RS15275	COG2199	diguanylate cyclase activity
AC611_RS15280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC611_RS15285	COG2201	protein-glutamate methylesterase activity
AC611_RS15295	COG3590	peptidase
AC611_RS15310	COG1515	deoxyribonuclease V activity
AC611_RS15320	COG1741	Belongs to the pirin family
AC611_RS15335	COG1741	Belongs to the pirin family
AC611_RS15340	COG1966	Carbon starvation protein
AC611_RS15345	COG2879	small protein
AC611_RS15390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC611_RS15395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC611_RS15400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC611_RS15405	COG2080	2 iron, 2 sulfur cluster binding
AC611_RS15410	COG3321	synthase
AC611_RS15410	COG0604	alcohol dehydrogenase
AC611_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS15415	COG2203	Gaf domain
AC611_RS15415	COG5001	Diguanylate cyclase
AC611_RS15415	COG4251	negative regulation of phosphorylation
AC611_RS15415	COG3706	GGDEF domain
AC611_RS15420	COG0629	single-stranded DNA binding
AC611_RS15425	COG0142	geranyltranstransferase activity
AC611_RS15435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC611_RS15450	COG0527	aspartate kinase activity
AC611_RS15455	COG0384	phenazine biosynthesis protein PhzF
AC611_RS15460	COG0384	phenazine biosynthesis protein PhzF
AC611_RS15470	COG1764	response to oxidative stress
AC611_RS15475	COG0540	Belongs to the ATCase OTCase family
AC611_RS15480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC611_RS15485	COG1678	Uncharacterized ACR, COG1678
AC611_RS15490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AC611_RS15495	COG0519	Catalyzes the synthesis of GMP from XMP
AC611_RS15520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC611_RS15535	COG0739	heme binding
AC611_RS15555	COG0693	protein deglycase activity
AC611_RS15565	COG1959	2 iron, 2 sulfur cluster binding
AC611_RS15570	COG0719	Fe-S assembly protein
AC611_RS15575	COG0396	ATPase activity
AC611_RS15580	COG0719	Fe-S assembly protein
AC611_RS15585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC611_RS15595	COG0456	acetyltransferase
AC611_RS15600	COG2146	nitrite reductase [NAD(P)H] activity
AC611_RS15605	COG4774	siderophore transport
AC611_RS15610	COG3128	pkhd-type hydroxylase
AC611_RS15635	COG3328	transposase activity
AC611_RS15640	COG1477	protein flavinylation
AC611_RS15645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC611_RS15655	COG1555	photosystem II stabilization
AC611_RS15675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC611_RS15685	COG0628	permease
AC611_RS15695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC611_RS15710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC611_RS15730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC611_RS15735	COG0271	Belongs to the BolA IbaG family
AC611_RS15745	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AC611_RS15755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC611_RS15760	COG1137	ATPase activity
AC611_RS15775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC611_RS15780	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC611_RS15785	COG1660	Displays ATPase and GTPase activities
AC611_RS15795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC611_RS15810	COG2239	Acts as a magnesium transporter
AC611_RS15820	COG1294	oxidase, subunit
AC611_RS15875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC611_RS15895	COG2951	lytic endotransglycosylase activity
AC611_RS15995	COG1113	amino acid transport
AC611_RS16030	COG2197	response regulator
AC611_RS16035	COG0531	amino acid
AC611_RS16125	COG2814	Major facilitator Superfamily
AC611_RS16135	COG0754	glutathionylspermidine amidase activity
AC611_RS16160	COG1842	Phage shock protein A
AC611_RS16170	COG0259	pyridoxamine-phosphate oxidase activity
AC611_RS16175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC611_RS16180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC611_RS16190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC611_RS16195	COG2814	Major facilitator Superfamily
AC611_RS16220	COG2205	protein histidine kinase activity
AC611_RS16220	COG2198	Histidine kinase
AC611_RS16220	COG0784	Response regulator, receiver
AC611_RS16225	COG2353	YceI-like domain
AC611_RS16245	COG1760	l-serine dehydratase
AC611_RS16255	COG0527	aspartate kinase activity
AC611_RS16255	COG0460	homoserine dehydrogenase
AC611_RS16260	COG0626	cystathionine gamma-synthase activity
AC611_RS16265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC611_RS16270	COG0739	heme binding
AC611_RS16275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC611_RS16280	COG1272	protein, Hemolysin III
AC611_RS16285	COG2982	Protein involved in outer membrane biogenesis
AC611_RS16290	COG0517	IMP dehydrogenase activity
AC611_RS16290	COG0516	GMP reductase activity
AC611_RS16295	COG0463	Glycosyl transferase, family 2
AC611_RS16300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC611_RS16305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC611_RS16315	COG4771	TonB-dependent receptor
AC611_RS16320	COG1309	transcriptional regulator
AC611_RS16330	COG1960	acyl-CoA dehydrogenase activity
AC611_RS16360	COG3328	transposase activity
AC611_RS16390	COG0509	glycine decarboxylation via glycine cleavage system
AC611_RS16395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC611_RS16405	COG0330	HflC and HflK could
AC611_RS16410	COG1742	UPF0060 membrane protein
AC611_RS16415	COG3956	TIGRFAM MazG family protein
AC611_RS16425	COG0494	nUDIX hydrolase
AC611_RS16435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC611_RS16440	COG0837	glucose binding
AC611_RS16475	COG3858	chitin binding
AC611_RS16475	COG1388	LysM domain
AC611_RS16490	COG1472	Belongs to the glycosyl hydrolase 3 family
AC611_RS16500	COG3537	Alpha-1,2-mannosidase
AC611_RS16545	COG3142	Participates in the control of copper homeostasis
AC611_RS16550	COG1446	asparaginase
AC611_RS16580	COG2198	Histidine kinase
AC611_RS16580	COG0784	Response regulator, receiver
AC611_RS16580	COG0643	Histidine kinase
AC611_RS16585	COG0840	transmembrane signaling receptor activity
AC611_RS16590	COG0835	chemotaxis
AC611_RS16605	COG0189	ligase activity
AC611_RS16615	COG1397	ADP-ribosylglycohydrolase
AC611_RS16625	COG1199	ATP-dependent helicase activity
AC611_RS16635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC611_RS16640	COG1215	transferase activity, transferring glycosyl groups
AC611_RS16655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC611_RS16665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC611_RS16670	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC611_RS16675	COG0535	radical SAM domain protein
AC611_RS16680	COG0535	radical SAM domain protein
AC611_RS16695	COG0837	glucose binding
AC611_RS16705	COG3328	transposase activity
AC611_RS16715	COG1643	Atp-dependent helicase
AC611_RS16720	COG0783	Belongs to the Dps family
AC611_RS16725	COG0514	ATP-dependent DNA helicase (RecQ)
AC611_RS16770	COG0840	transmembrane signaling receptor activity
AC611_RS16790	COG3920	Histidine kinase
AC611_RS16795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AC611_RS16805	COG0602	queuosine metabolic process
AC611_RS16815	COG2885	chlorophyll binding
AC611_RS16820	COG0823	Involved in the tonB-independent uptake of proteins
AC611_RS16830	COG0848	biopolymer transport protein
AC611_RS16840	COG0824	Thioesterase
AC611_RS16845	COG2255	four-way junction helicase activity
AC611_RS16855	COG3158	transport of potassium into the cell
AC611_RS16860	COG0632	four-way junction helicase activity
AC611_RS16865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC611_RS16870	COG0217	transcriptional regulatory protein
AC611_RS16885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC611_RS16900	COG0477	Major facilitator Superfamily
AC611_RS16925	COG2755	lipolytic protein G-D-S-L family
AC611_RS16925	COG0657	acetylesterase activity
AC611_RS16945	COG0488	(ABC) transporter
AC611_RS16980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC611_RS16980	COG4651	solute:proton antiporter activity
AC611_RS17005	COG4772	TonB-dependent receptor
AC611_RS17015	COG4264	IucA IucC family
AC611_RS17030	COG0019	diaminopimelate decarboxylase activity
AC611_RS17055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC611_RS17065	COG1492	cobalamin metabolic process
AC611_RS17075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC611_RS17095	COG4206	TonB-dependent receptor
AC611_RS17105	COG0542	response to heat
AC611_RS17150	COG1877	trehalose-phosphatase activity
AC611_RS17155	COG3387	PFAM Glycoside hydrolase 15-related
AC611_RS17185	COG0840	transmembrane signaling receptor activity
AC611_RS17190	COG3011	Protein conserved in bacteria
AC611_RS17205	COG0564	pseudouridine synthase activity
AC611_RS17210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC611_RS17220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC611_RS17220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC611_RS17235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC611_RS17240	COG0045	succinate-CoA ligase (ADP-forming) activity
AC611_RS17285	COG3328	transposase activity
AC611_RS17295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC611_RS17300	COG0237	dephospho-CoA kinase activity
AC611_RS17330	COG0745	RESPONSE REGULATOR receiver
AC611_RS17340	COG0189	ligase activity
AC611_RS17380	COG2003	Belongs to the UPF0758 family
AC611_RS17405	COG3039	Transposase
AC611_RS17415	COG3328	transposase activity
AC611_RS17425	COG3328	transposase activity
AC611_RS17490	COG1192	Involved in chromosome partitioning
AC611_RS17560	COG0270	DNA (cytosine-5-)-methyltransferase activity
AC611_RS17660	COG3328	transposase activity
AC611_RS17795	COG5001	Diguanylate cyclase
AC611_RS17925	COG0583	DNA-binding transcription factor activity
AC611_RS17950	COG0582	viral genome integration into host DNA
AC611_RS17970	COG2022	thiamine diphosphate biosynthetic process
AC611_RS17975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC611_RS17980	COG3273	potassium ion transport
AC611_RS17980	COG0471	metal ion transport
AC611_RS18005	COG1970	mechanosensitive ion channel activity
AC611_RS18015	COG1609	Transcriptional regulator
AC611_RS18025	COG3250	beta-galactosidase activity
AC611_RS18030	COG4948	Mandelate Racemase Muconate Lactonizing
AC611_RS18040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC611_RS18050	COG0308	aminopeptidase N
AC611_RS18055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC611_RS18065	COG2895	sulfate adenylyltransferase (ATP) activity
AC611_RS18065	COG0529	Catalyzes the synthesis of activated sulfate
AC611_RS18070	COG0175	sulfate reduction
AC611_RS18075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC611_RS18080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC611_RS18085	COG0175	sulfate reduction
AC611_RS18105	COG2205	protein histidine kinase activity
AC611_RS18105	COG2198	Histidine kinase
AC611_RS18105	COG0784	Response regulator, receiver
AC611_RS18125	COG1648	precorrin-2 dehydrogenase activity
AC611_RS18125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC611_RS18140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AC611_RS18145	COG3588	fructose-bisphosphate aldolase
AC611_RS18155	COG0469	pyruvate kinase activity
AC611_RS18165	COG0126	phosphoglycerate kinase activity
AC611_RS18195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC611_RS18205	COG3047	cAMP biosynthetic process
AC611_RS18220	COG3453	Protein conserved in bacteria
AC611_RS18220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC611_RS18225	COG0725	ABC transporter, periplasmic molybdate-binding protein
AC611_RS18230	COG4149	molybdate abc transporter
AC611_RS18235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AC611_RS18255	COG0642	Histidine kinase
AC611_RS18280	COG1022	Amp-dependent synthetase and ligase
AC611_RS18305	COG1376	ErfK ybiS ycfS ynhG family protein
AC611_RS18310	COG0739	heme binding
AC611_RS18325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC611_RS18330	COG1301	dicarboxylic acid transport
AC611_RS18340	COG2304	oxidoreductase activity
AC611_RS18360	COG0714	Associated with various cellular activities
AC611_RS18390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC611_RS18410	COG1957	nucleoside hydrolase
AC611_RS18415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC611_RS18425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC611_RS18440	COG1561	YicC-like family, N-terminal region
AC611_RS18445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC611_RS18455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC611_RS18460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC611_RS18475	COG0006	proline dipeptidase activity
AC611_RS18485	COG0006	proline dipeptidase activity
AC611_RS18490	COG3079	Belongs to the UPF0149 family
AC611_RS18510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC611_RS18530	COG2912	Transglutaminase-like superfamily
AC611_RS18540	COG1773	rubredoxin
AC611_RS18545	COG0352	thiamine-phosphate diphosphorylase activity
AC611_RS18575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC611_RS18585	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AC611_RS18590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC611_RS18620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC611_RS18625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC611_RS18630	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS18640	COG0671	phosphoesterase, PA-phosphatase related
AC611_RS18650	COG3781	membrane
AC611_RS18660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC611_RS18665	COG0563	adenylate kinase activity
AC611_RS18680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AC611_RS18690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC611_RS18710	COG3710	Transcriptional regulator
AC611_RS18715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC611_RS18730	COG0840	transmembrane signaling receptor activity
AC611_RS18735	COG0405	Gamma-glutamyltransferase
AC611_RS18740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC611_RS18760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC611_RS18765	COG0473	3-isopropylmalate dehydrogenase activity
AC611_RS18770	COG0066	3-isopropylmalate dehydratase activity
AC611_RS18775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC611_RS18795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC611_RS18800	COG1538	Outer membrane efflux protein
AC611_RS18805	COG1519	Transferase
AC611_RS18810	COG1560	Kdo2-lipid A biosynthetic process
AC611_RS18835	COG0280	phosphate acetyltransferase
AC611_RS18835	COG0281	malic enzyme
AC611_RS18840	COG1301	dicarboxylic acid transport
AC611_RS18865	COG0583	DNA-binding transcription factor activity
AC611_RS18875	COG0667	Aldo Keto reductase
AC611_RS18890	COG2197	response regulator
AC611_RS18905	COG0642	Histidine kinase
AC611_RS18925	COG2851	Citrate transporter
AC611_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS18935	COG1609	Transcriptional regulator
AC611_RS18940	COG2211	Major facilitator Superfamily
AC611_RS18965	COG1162	GTPase activity
AC611_RS18970	COG0436	Aminotransferase
AC611_RS18985	COG0726	polysaccharide deacetylase
AC611_RS18990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC611_RS19005	COG3964	amidohydrolase
AC611_RS19010	COG0402	S-adenosylhomocysteine deaminase activity
AC611_RS19040	COG3328	transposase activity
AC611_RS19055	COG1307	EDD domain protein, DegV family
AC611_RS19075	COG3791	Glutathione-dependent formaldehyde-activating
AC611_RS19105	COG2205	protein histidine kinase activity
AC611_RS19120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC611_RS19135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC611_RS19145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC611_RS19150	COG1012	belongs to the aldehyde dehydrogenase family
AC611_RS19155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC611_RS19175	COG1183	phosphatidylcholine synthase activity
AC611_RS19185	COG0442	prolyl-tRNA aminoacylation
AC611_RS19200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC611_RS19205	COG1127	ABC transporter
AC611_RS19210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC611_RS19210	COG3218	ABC-type transport auxiliary lipoprotein component
AC611_RS19240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC611_RS19245	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC611_RS19245	COG0662	Cupin 2, conserved barrel domain protein
AC611_RS19275	COG2086	electron transfer activity
AC611_RS19290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC611_RS19290	COG0546	phosphoglycolate phosphatase activity
AC611_RS19295	COG0277	FAD linked oxidase domain protein
AC611_RS19305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC611_RS19340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC611_RS19345	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AC611_RS19350	COG0438	transferase activity, transferring glycosyl groups
AC611_RS19370	COG0438	transferase activity, transferring glycosyl groups
AC611_RS19380	COG0626	cystathionine gamma-synthase activity
AC611_RS19410	COG0625	glutathione transferase activity
AC611_RS19425	COG0513	Belongs to the DEAD box helicase family
AC611_RS19430	COG0720	synthase
AC611_RS19440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC611_RS19450	COG1956	GAF domain-containing protein
AC611_RS19465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC611_RS19470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC611_RS19480	COG4991	sh3 domain protein
AC611_RS19490	COG0339	signal peptide processing
AC611_RS19505	COG2132	Multicopper oxidase
AC611_RS19540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC611_RS19545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC611_RS19550	COG1136	(ABC) transporter
AC611_RS19555	COG0577	efflux transmembrane transporter activity
AC611_RS19555	COG1136	(ABC) transporter
AC611_RS19575	COG4191	Histidine kinase
AC611_RS19580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC611_RS19605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC611_RS19610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC611_RS19615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC611_RS19620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC611_RS19625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC611_RS19640	COG0356	it plays a direct role in the translocation of protons across the membrane
AC611_RS19660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC611_RS19670	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC611_RS19710	COG2011	ABC-type metal ion transport system permease component
AC611_RS19715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC611_RS19720	COG0697	spore germination
AC611_RS19725	COG1666	GTP binding
AC611_RS19735	COG2198	Histidine kinase
AC611_RS19735	COG0784	Response regulator, receiver
AC611_RS19735	COG5002	protein histidine kinase activity
AC611_RS19760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC611_RS19765	COG1187	pseudouridine synthase activity
AC611_RS19770	COG2813	Specifically methylates the guanine in position
AC611_RS19785	COG3039	Transposase
AC611_RS19790	COG3328	transposase activity
AC611_RS19805	COG2202	Pas domain
AC611_RS19805	COG2205	protein histidine kinase activity
AC611_RS19825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC611_RS19830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC611_RS19885	COG0842	Transport permease protein
AC611_RS19890	COG1131	(ABC) transporter
AC611_RS19895	COG0025	NhaP-type Na H and K H
AC611_RS19905	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AC611_RS19910	COG1573	uracil-dna glycosylase
AC611_RS19920	COG3384	dioxygenase
AC611_RS19930	COG0583	DNA-binding transcription factor activity
AC611_RS19940	COG0667	Aldo Keto reductase
AC611_RS19955	COG3590	peptidase
AC611_RS19970	COG0531	amino acid
AC611_RS19985	COG2972	Histidine kinase
AC611_RS20005	COG3685	Protein conserved in bacteria
AC611_RS20010	COG3546	catalase activity
AC611_RS20060	COG1271	oxidase subunit
AC611_RS20065	COG1294	oxidase, subunit
AC611_RS20080	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS20100	COG1063	alcohol dehydrogenase
AC611_RS20110	COG3328	transposase activity
AC611_RS20180	COG0251	oxidation-reduction process
AC611_RS20205	COG0659	secondary active sulfate transmembrane transporter activity
AC611_RS20210	COG0038	chloride channel
AC611_RS20220	COG0024	Methionine aminopeptidase
AC611_RS20255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC611_RS20260	COG1490	D-aminoacyl-tRNA deacylase activity
AC611_RS20265	COG1560	Kdo2-lipid A biosynthetic process
AC611_RS20310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC611_RS20310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC611_RS20315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC611_RS20320	COG0242	peptide deformylase activity
AC611_RS20325	COG1652	LysM domain
AC611_RS20330	COG0758	DNA mediated transformation
AC611_RS20350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC611_RS20350	COG1754	DNA topoisomerase type I activity
AC611_RS20355	COG0009	L-threonylcarbamoyladenylate synthase
AC611_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS20380	COG0616	signal peptide processing
AC611_RS20385	COG0534	Mate efflux family protein
AC611_RS20405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AC611_RS20410	COG0625	glutathione transferase activity
AC611_RS20430	COG2860	membrane
AC611_RS20435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC611_RS20440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC611_RS20445	COG3437	response regulator, receiver
AC611_RS20450	COG2177	Part of the ABC transporter FtsEX involved in
AC611_RS20455	COG2884	Cell division ATP-binding protein ftsE
AC611_RS20460	COG0513	Belongs to the DEAD box helicase family
AC611_RS20465	COG3118	belongs to the thioredoxin family
AC611_RS20470	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC611_RS20480	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AC611_RS20505	COG1652	LysM domain
AC611_RS20510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC611_RS20510	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC611_RS20515	COG1473	amidohydrolase
AC611_RS20520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC611_RS20525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC611_RS20545	COG5383	Protein conserved in bacteria
AC611_RS20570	COG3328	transposase activity
AC611_RS20590	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AC611_RS20595	COG3023	N-Acetylmuramoyl-L-alanine amidase
AC611_RS20615	COG0531	amino acid
AC611_RS20635	COG3328	transposase activity
AC611_RS20640	COG4682	membrane
AC611_RS20645	COG2133	pyrroloquinoline quinone binding
AC611_RS20670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC611_RS20675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC611_RS20685	COG1610	YqeY-like protein
AC611_RS20695	COG1295	ribonuclease BN
AC611_RS20700	COG0358	DNA primase activity
AC611_RS20715	COG0109	protoheme IX farnesyltransferase activity
AC611_RS20745	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC611_RS20760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC611_RS20800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC611_RS20805	COG0739	heme binding
AC611_RS20810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AC611_RS20820	COG2211	Major facilitator Superfamily
AC611_RS20825	COG0708	Exodeoxyribonuclease III
AC611_RS20830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC611_RS20840	COG1192	Involved in chromosome partitioning
AC611_RS20845	COG1475	DNA binding
AC611_RS20860	COG0463	Glycosyl transferase, family 2
AC611_RS20880	COG0756	dUTP diphosphatase activity
AC611_RS20885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AC611_RS20890	COG2003	Belongs to the UPF0758 family
AC611_RS20895	COG0018	arginyl-trna synthetase
AC611_RS20910	COG4221	oxidoreductase activity
AC611_RS20915	COG2755	lipolytic protein G-D-S-L family
AC611_RS20915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC611_RS20925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AC611_RS20930	COG1166	arginine decarboxylase activity
AC611_RS20935	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC611_RS20955	COG3291	Pkd domain containing protein
AC611_RS20955	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AC611_RS20975	COG0606	chelatase, subunit chli
AC611_RS20990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC611_RS21025	COG1690	Belongs to the RtcB family
AC611_RS21065	COG1090	epimerase
AC611_RS21075	COG0642	Histidine kinase
AC611_RS21095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC611_RS21120	COG1011	Hydrolase
AC611_RS21125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC611_RS21140	COG0753	catalase activity
AC611_RS21155	COG2197	response regulator
AC611_RS21160	COG4585	Histidine kinase
AC611_RS21165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC611_RS21170	COG1136	(ABC) transporter
AC611_RS21195	COG0697	spore germination
AC611_RS21220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC611_RS21225	COG0180	Tryptophanyl-tRNA synthetase
AC611_RS21230	COG3237	CsbD-like
AC611_RS21275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC611_RS21290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC611_RS21295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AC611_RS21295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AC611_RS21310	COG3228	Belongs to the MtfA family
AC611_RS21340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC611_RS21380	COG3328	transposase activity
AC611_RS21395	COG1199	ATP-dependent helicase activity
AC611_RS21410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC611_RS21500	COG4555	ABC transporter
AC611_RS21510	COG1476	TRANSCRIPTIONal
AC611_RS21530	COG1230	cation diffusion facilitator family transporter
AC611_RS21535	COG0543	2 iron, 2 sulfur cluster binding
AC611_RS21535	COG0633	Ferredoxin
AC611_RS21540	COG1131	(ABC) transporter
AC611_RS21545	COG0842	Transport permease protein
AC611_RS21550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC611_RS21585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC611_RS21605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC611_RS21610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC611_RS21625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC611_RS21625	COG1042	CoA-binding domain protein
AC611_RS21625	COG0045	succinate-CoA ligase (ADP-forming) activity
AC611_RS21630	COG2239	Acts as a magnesium transporter
AC611_RS21670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC611_RS21675	COG3387	PFAM Glycoside hydrolase 15-related
AC611_RS21690	COG3100	YcgL domain-containing protein
AC611_RS21695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC611_RS21705	COG0463	Glycosyl transferase, family 2
AC611_RS21720	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS21760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC611_RS21775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC611_RS21825	COG0408	coproporphyrinogen oxidase activity
AC611_RS21865	COG0515	serine threonine protein kinase
AC611_RS21870	COG0631	protein serine/threonine phosphatase activity
AC611_RS21895	COG0667	Aldo Keto reductase
AC611_RS21900	COG0583	DNA-binding transcription factor activity
AC611_RS21975	COG0154	amidase activity
AC611_RS22000	COG3328	transposase activity
AC611_RS22085	COG0210	DNA helicase
AC611_RS22100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC611_RS22105	COG0583	DNA-binding transcription factor activity
AC611_RS22110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC611_RS22125	COG2159	amidohydrolase
AC611_RS22155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC611_RS22180	COG0357	Ribosomal RNA small subunit methyltransferase G
AC611_RS22185	COG3540	Alkaline phosphatase
AC611_RS22195	COG2091	lysine biosynthetic process via aminoadipic acid
AC611_RS22210	COG0708	Exodeoxyribonuclease III
AC611_RS22215	COG1846	Transcriptional regulator
AC611_RS22215	COG1940	carbohydrate kinase activity
AC611_RS22235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC611_RS22240	COG3162	membrane
AC611_RS22250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC611_RS22285	COG3507	Belongs to the glycosyl hydrolase 43 family
AC611_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS22310	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC611_RS22315	COG4948	Mandelate Racemase Muconate Lactonizing
AC611_RS22320	COG3254	rhamnose metabolic process
AC611_RS22325	COG0738	Major facilitator superfamily
AC611_RS22330	COG1414	Transcriptional regulator
AC611_RS22335	COG2207	Transcriptional regulator
AC611_RS22335	COG1917	Cupin 2, conserved barrel domain protein
AC611_RS22345	COG1971	Probably functions as a manganese efflux pump
AC611_RS22350	COG2205	protein histidine kinase activity
AC611_RS22365	COG3459	Glycosyltransferase 36 associated
AC611_RS22370	COG2211	Major facilitator Superfamily
AC611_RS22375	COG3265	gluconokinase activity
AC611_RS22385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC611_RS22405	COG2911	Protein conserved in bacteria
AC611_RS22410	COG0729	surface antigen
AC611_RS22415	COG4771	TonB-dependent receptor
AC611_RS22420	COG0457	Tetratricopeptide repeat
AC611_RS22430	COG0752	glycyl-tRNA synthetase alpha subunit
AC611_RS22435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC611_RS22450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC611_RS22450	COG0519	Catalyzes the synthesis of GMP from XMP
AC611_RS22465	COG0805	protein transport
AC611_RS22470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC611_RS22475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC611_RS22485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC611_RS22515	COG2974	May be involved in recombination
AC611_RS22520	COG0037	tRNA processing
AC611_RS22530	COG2115	Belongs to the xylose isomerase family
AC611_RS22540	COG3661	Belongs to the glycosyl hydrolase 67 family
AC611_RS22550	COG4948	Mandelate Racemase Muconate Lactonizing
AC611_RS22560	COG1472	Belongs to the glycosyl hydrolase 3 family
AC611_RS22565	COG0246	Mannitol dehydrogenase
AC611_RS22630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC611_RS22655	COG3386	PFAM SMP-30 Gluconolaconase
AC611_RS22665	COG3250	beta-galactosidase activity
AC611_RS22670	COG1904	glucuronate isomerase
AC611_RS22675	COG3693	PFAM glycoside hydrolase, family 10
AC611_RS22685	COG3693	PFAM glycoside hydrolase, family 10
AC611_RS22700	COG2211	Major facilitator Superfamily
AC611_RS22785	COG2937	Belongs to the GPAT DAPAT family
AC611_RS22820	COG0284	orotidine-5'-phosphate decarboxylase activity
AC611_RS22825	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AC611_RS22840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC611_RS22890	COG0210	DNA helicase
AC611_RS22895	COG1435	thymidine kinase activity
AC611_RS22905	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AC611_RS22930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC611_RS22960	COG3135	benzoate transporter
AC611_RS22990	COG0676	glucose-6-phosphate 1-epimerase activity
AC611_RS23000	COG3012	SEC-C Motif Domain Protein
AC611_RS23045	COG3328	transposase activity
AC611_RS23070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC611_RS23080	COG4221	oxidoreductase activity
AC611_RS23085	COG0583	DNA-binding transcription factor activity
AC611_RS23095	COG0477	Major facilitator Superfamily
AC611_RS23100	COG1289	transmembrane transporter activity
AC611_RS23110	COG1566	PFAM secretion protein HlyD family protein
AC611_RS23125	COG0302	gtp cyclohydrolase
AC611_RS23150	COG3328	transposase activity
AC611_RS23160	COG0730	response to heat
AC611_RS23175	COG3328	transposase activity
AC611_RS23200	COG0564	pseudouridine synthase activity
AC611_RS23315	COG4790	Type iii secretion
AC611_RS23475	COG3039	Transposase
AC611_RS23595	COG0439	Biotin carboxylase
AC611_RS23620	COG1028	Short-chain dehydrogenase reductase Sdr
AC611_RS23680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC611_RS23685	COG1074	ATP-dependent DNA helicase activity
AC611_RS23690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC611_RS23725	COG1127	ABC transporter
AC611_RS23730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC611_RS23735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC611_RS23750	COG2853	Lipoprotein
AC611_RS23765	COG0386	Belongs to the glutathione peroxidase family
AC611_RS23775	COG1322	Protein conserved in bacteria
AC611_RS23785	COG0583	DNA-binding transcription factor activity
AC611_RS23805	COG0531	amino acid
AC611_RS23810	COG3537	Alpha-1,2-mannosidase
AC611_RS23825	COG2199	diguanylate cyclase activity
AC611_RS23825	COG2203	Gaf domain
AC611_RS23830	COG3835	regulator
AC611_RS23835	COG1929	Belongs to the glycerate kinase type-1 family
AC611_RS23855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC611_RS23865	COG0861	Integral membrane protein TerC family
AC611_RS23885	COG0584	glycerophosphoryl diester phosphodiesterase
AC611_RS23900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC611_RS23905	COG0726	polysaccharide deacetylase
AC611_RS23910	COG0706	membrane insertase activity
AC611_RS23915	COG0594	ribonuclease P activity
AC611_RS24065	COG3328	transposase activity
AC611_RS24110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC611_RS24115	COG4691	Plasmid stability protein
AC611_RS24120	COG1487	ribonuclease activity
AC611_RS24190	COG3846	protein secretion by the type IV secretion system
AC611_RS24205	COG3451	type IV secretory pathway VirB4
AC611_RS24220	COG4962	Type ii secretion system protein e
AC611_RS24375	COG3328	transposase activity
AC611_RS24380	COG3039	Transposase
AC611_RS24530	COG1487	ribonuclease activity
AC611_RS24535	COG4691	Plasmid stability protein
AC611_RS24540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs