locus-tag	class	description
DGM85_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGM85_RS00020	COG0187	DNA topoisomerase II activity
DGM85_RS00030	COG0501	Belongs to the peptidase M48B family
DGM85_RS00085	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS00090	COG0300	oxidoreductase activity
DGM85_RS00110	COG1272	protein, Hemolysin III
DGM85_RS00115	COG1111	helicase
DGM85_RS00115	COG1205	dead DEAH box helicase
DGM85_RS00205	COG0070	glutamate synthase
DGM85_RS00205	COG0067	glutamate synthase
DGM85_RS00205	COG0069	glutamate synthase activity
DGM85_RS00210	COG0493	'glutamate synthase
DGM85_RS00225	COG1064	alcohol dehydrogenase
DGM85_RS00230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_RS00240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_RS00245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_RS00255	COG2234	aminopeptidase activity
DGM85_RS00265	COG4942	peptidase
DGM85_RS00270	COG0793	Belongs to the peptidase S41A family
DGM85_RS00315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_RS00325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGM85_RS00350	COG3039	Transposase
DGM85_RS00365	COG3039	Transposase
DGM85_RS00375	COG3237	CsbD-like
DGM85_RS00425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_RS00430	COG0477	Major facilitator Superfamily
DGM85_RS00475	COG0714	Associated with various cellular activities
DGM85_RS00515	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DGM85_RS00525	COG4772	TonB-dependent receptor
DGM85_RS00550	COG1304	FMN binding
DGM85_RS00555	COG1755	Isoprenylcysteine carboxyl methyltransferase
DGM85_RS00560	COG4585	Histidine kinase
DGM85_RS00565	COG2197	response regulator
DGM85_RS00590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGM85_RS00630	COG2801	Transposase and inactivated derivatives
DGM85_RS00640	COG3328	transposase activity
DGM85_RS00650	COG0730	response to heat
DGM85_RS00670	COG3039	Transposase
DGM85_RS00690	COG3328	transposase activity
DGM85_RS00695	COG3012	SEC-C Motif Domain Protein
DGM85_RS00705	COG0676	glucose-6-phosphate 1-epimerase activity
DGM85_RS00735	COG3135	benzoate transporter
DGM85_RS00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGM85_RS00775	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGM85_RS00785	COG1435	thymidine kinase activity
DGM85_RS00790	COG0210	DNA helicase
DGM85_RS00840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGM85_RS00855	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGM85_RS00860	COG0284	orotidine-5'-phosphate decarboxylase activity
DGM85_RS00890	COG2937	Belongs to the GPAT DAPAT family
DGM85_RS00930	COG3328	transposase activity
DGM85_RS00945	COG2211	Major facilitator Superfamily
DGM85_RS00960	COG3693	PFAM glycoside hydrolase, family 10
DGM85_RS00965	COG3039	Transposase
DGM85_RS00970	COG3693	PFAM glycoside hydrolase, family 10
DGM85_RS00975	COG1904	glucuronate isomerase
DGM85_RS00990	COG3386	PFAM SMP-30 Gluconolaconase
DGM85_RS01015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGM85_RS01070	COG0246	Mannitol dehydrogenase
DGM85_RS01085	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_RS01095	COG3661	Belongs to the glycosyl hydrolase 67 family
DGM85_RS01105	COG2115	Belongs to the xylose isomerase family
DGM85_RS01110	COG0037	tRNA processing
DGM85_RS01115	COG2974	May be involved in recombination
DGM85_RS01135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGM85_RS01145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGM85_RS01150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGM85_RS01155	COG0805	protein transport
DGM85_RS01170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGM85_RS01170	COG0519	Catalyzes the synthesis of GMP from XMP
DGM85_RS01180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGM85_RS01185	COG0752	glycyl-tRNA synthetase alpha subunit
DGM85_RS01195	COG0457	Tetratricopeptide repeat
DGM85_RS01200	COG4771	TonB-dependent receptor
DGM85_RS01205	COG0729	surface antigen
DGM85_RS01210	COG2911	Protein conserved in bacteria
DGM85_RS01230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_RS01235	COG3265	gluconokinase activity
DGM85_RS01240	COG2211	Major facilitator Superfamily
DGM85_RS01245	COG3459	Glycosyltransferase 36 associated
DGM85_RS01255	COG2205	protein histidine kinase activity
DGM85_RS01260	COG1971	Probably functions as a manganese efflux pump
DGM85_RS01270	COG2207	Transcriptional regulator
DGM85_RS01270	COG1917	Cupin 2, conserved barrel domain protein
DGM85_RS01275	COG1414	Transcriptional regulator
DGM85_RS01280	COG0738	Major facilitator superfamily
DGM85_RS01285	COG3254	rhamnose metabolic process
DGM85_RS01290	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_RS01295	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGM85_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS01320	COG3507	Belongs to the glycosyl hydrolase 43 family
DGM85_RS01355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGM85_RS01365	COG3162	membrane
DGM85_RS01370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGM85_RS01380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM85_RS01390	COG1846	Transcriptional regulator
DGM85_RS01390	COG1940	carbohydrate kinase activity
DGM85_RS01395	COG0708	Exodeoxyribonuclease III
DGM85_RS01410	COG2091	lysine biosynthetic process via aminoadipic acid
DGM85_RS01420	COG3540	Alkaline phosphatase
DGM85_RS01425	COG0357	Ribosomal RNA small subunit methyltransferase G
DGM85_RS01445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_RS01450	COG3328	transposase activity
DGM85_RS01480	COG2159	amidohydrolase
DGM85_RS01490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGM85_RS01495	COG0583	DNA-binding transcription factor activity
DGM85_RS01500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_RS01515	COG0210	DNA helicase
DGM85_RS01595	COG3328	transposase activity
DGM85_RS01620	COG0154	amidase activity
DGM85_RS01690	COG0583	DNA-binding transcription factor activity
DGM85_RS01695	COG0667	Aldo Keto reductase
DGM85_RS01720	COG0631	protein serine/threonine phosphatase activity
DGM85_RS01760	COG0408	coproporphyrinogen oxidase activity
DGM85_RS01795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGM85_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS01865	COG0463	Glycosyl transferase, family 2
DGM85_RS01875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGM85_RS01880	COG3100	YcgL domain-containing protein
DGM85_RS01895	COG3387	PFAM Glycoside hydrolase 15-related
DGM85_RS01900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGM85_RS01915	COG3338	carbonate dehydratase activity
DGM85_RS01920	COG2239	Acts as a magnesium transporter
DGM85_RS01925	COG1042	CoA-binding domain protein
DGM85_RS01925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGM85_RS01925	COG0045	succinate-CoA ligase (ADP-forming) activity
DGM85_RS01935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGM85_RS01940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGM85_RS01960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_RS01985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGM85_RS01990	COG0842	Transport permease protein
DGM85_RS01995	COG1131	(ABC) transporter
DGM85_RS02000	COG2801	Transposase and inactivated derivatives
DGM85_RS02005	COG0543	2 iron, 2 sulfur cluster binding
DGM85_RS02005	COG0633	Ferredoxin
DGM85_RS02010	COG1230	cation diffusion facilitator family transporter
DGM85_RS02030	COG1476	TRANSCRIPTIONal
DGM85_RS02040	COG4555	ABC transporter
DGM85_RS02130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGM85_RS02145	COG1199	ATP-dependent helicase activity
DGM85_RS02200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGM85_RS02230	COG3228	Belongs to the MtfA family
DGM85_RS02240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DGM85_RS02240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DGM85_RS02245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGM85_RS02260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGM85_RS02300	COG3237	CsbD-like
DGM85_RS02305	COG0180	Tryptophanyl-tRNA synthetase
DGM85_RS02310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM85_RS02335	COG0697	spore germination
DGM85_RS02360	COG1136	(ABC) transporter
DGM85_RS02365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_RS02370	COG4585	Histidine kinase
DGM85_RS02375	COG2197	response regulator
DGM85_RS02390	COG0753	catalase activity
DGM85_RS02405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGM85_RS02410	COG1011	Hydrolase
DGM85_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGM85_RS02455	COG0642	Histidine kinase
DGM85_RS02465	COG1090	epimerase
DGM85_RS02500	COG1690	Belongs to the RtcB family
DGM85_RS02525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGM85_RS02540	COG0606	chelatase, subunit chli
DGM85_RS02555	COG3291	Pkd domain containing protein
DGM85_RS02555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGM85_RS02575	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGM85_RS02580	COG1166	arginine decarboxylase activity
DGM85_RS02585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGM85_RS02595	COG2755	lipolytic protein G-D-S-L family
DGM85_RS02595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGM85_RS02600	COG4221	oxidoreductase activity
DGM85_RS02615	COG0018	arginyl-trna synthetase
DGM85_RS02620	COG2003	Belongs to the UPF0758 family
DGM85_RS02625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGM85_RS02630	COG0756	dUTP diphosphatase activity
DGM85_RS02650	COG0463	Glycosyl transferase, family 2
DGM85_RS02665	COG1475	DNA binding
DGM85_RS02670	COG1192	Involved in chromosome partitioning
DGM85_RS02680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGM85_RS02685	COG0708	Exodeoxyribonuclease III
DGM85_RS02690	COG2223	nitrite transmembrane transporter activity
DGM85_RS02700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DGM85_RS02705	COG0739	heme binding
DGM85_RS02710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DGM85_RS02750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGM85_RS02765	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGM85_RS02795	COG0109	protoheme IX farnesyltransferase activity
DGM85_RS02810	COG0358	DNA primase activity
DGM85_RS02815	COG1295	ribonuclease BN
DGM85_RS02820	COG1610	YqeY-like protein
DGM85_RS02835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGM85_RS02840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGM85_RS02850	COG2133	pyrroloquinoline quinone binding
DGM85_RS02855	COG4682	membrane
DGM85_RS02870	COG0531	amino acid
DGM85_RS02880	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_RS02890	COG3023	N-Acetylmuramoyl-L-alanine amidase
DGM85_RS02895	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DGM85_RS02930	COG5383	Protein conserved in bacteria
DGM85_RS02940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_RS02945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_RS02950	COG1473	amidohydrolase
DGM85_RS02955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGM85_RS02955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGM85_RS02960	COG1652	LysM domain
DGM85_RS02985	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGM85_RS02995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGM85_RS03000	COG3118	belongs to the thioredoxin family
DGM85_RS03010	COG2884	Cell division ATP-binding protein ftsE
DGM85_RS03015	COG2177	Part of the ABC transporter FtsEX involved in
DGM85_RS03020	COG2201	protein-glutamate methylesterase activity
DGM85_RS03025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGM85_RS03030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGM85_RS03035	COG2860	membrane
DGM85_RS03040	COG1252	NADH dehydrogenase
DGM85_RS03055	COG0625	glutathione transferase activity
DGM85_RS03060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGM85_RS03080	COG0534	Mate efflux family protein
DGM85_RS03085	COG0616	signal peptide processing
DGM85_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS03110	COG0009	L-threonylcarbamoyladenylate synthase
DGM85_RS03115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGM85_RS03115	COG1754	DNA topoisomerase type I activity
DGM85_RS03135	COG0758	DNA mediated transformation
DGM85_RS03140	COG1652	LysM domain
DGM85_RS03145	COG0242	peptide deformylase activity
DGM85_RS03150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DGM85_RS03155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGM85_RS03155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGM85_RS03200	COG1560	Kdo2-lipid A biosynthetic process
DGM85_RS03205	COG1490	D-aminoacyl-tRNA deacylase activity
DGM85_RS03210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGM85_RS03230	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS03245	COG0024	Methionine aminopeptidase
DGM85_RS03255	COG0038	chloride channel
DGM85_RS03260	COG0659	secondary active sulfate transmembrane transporter activity
DGM85_RS03290	COG0251	oxidation-reduction process
DGM85_RS03365	COG1063	alcohol dehydrogenase
DGM85_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS03400	COG1294	oxidase, subunit
DGM85_RS03405	COG1271	oxidase subunit
DGM85_RS03455	COG3546	catalase activity
DGM85_RS03460	COG3685	Protein conserved in bacteria
DGM85_RS03475	COG2972	Histidine kinase
DGM85_RS03490	COG0531	amino acid
DGM85_RS03505	COG3590	peptidase
DGM85_RS03515	COG0667	Aldo Keto reductase
DGM85_RS03525	COG0583	DNA-binding transcription factor activity
DGM85_RS03535	COG3384	dioxygenase
DGM85_RS03545	COG1573	uracil-dna glycosylase
DGM85_RS03550	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGM85_RS03555	COG0025	NhaP-type Na H and K H
DGM85_RS03560	COG1131	(ABC) transporter
DGM85_RS03565	COG0842	Transport permease protein
DGM85_RS03620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_RS03625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGM85_RS03645	COG2205	protein histidine kinase activity
DGM85_RS03645	COG2202	Pas domain
DGM85_RS03660	COG3328	transposase activity
DGM85_RS03675	COG3039	Transposase
DGM85_RS03680	COG2813	Specifically methylates the guanine in position
DGM85_RS03685	COG1187	pseudouridine synthase activity
DGM85_RS03690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGM85_RS03715	COG0784	Response regulator, receiver
DGM85_RS03715	COG5002	protein histidine kinase activity
DGM85_RS03715	COG2198	Histidine kinase
DGM85_RS03725	COG1666	GTP binding
DGM85_RS03730	COG0697	spore germination
DGM85_RS03735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGM85_RS03740	COG2011	ABC-type metal ion transport system permease component
DGM85_RS03780	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGM85_RS03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGM85_RS03810	COG0356	it plays a direct role in the translocation of protons across the membrane
DGM85_RS03825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGM85_RS03830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DGM85_RS03835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DGM85_RS03840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGM85_RS03845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGM85_RS03870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGM85_RS03875	COG4191	Histidine kinase
DGM85_RS03895	COG1136	(ABC) transporter
DGM85_RS03895	COG0577	efflux transmembrane transporter activity
DGM85_RS03900	COG1136	(ABC) transporter
DGM85_RS03905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_RS03910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGM85_RS03945	COG2132	Multicopper oxidase
DGM85_RS03960	COG0339	signal peptide processing
DGM85_RS03970	COG4991	sh3 domain protein
DGM85_RS03980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM85_RS03985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGM85_RS04000	COG1956	GAF domain-containing protein
DGM85_RS04010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGM85_RS04020	COG0720	synthase
DGM85_RS04025	COG0513	Belongs to the DEAD box helicase family
DGM85_RS04035	COG0625	glutathione transferase activity
DGM85_RS04065	COG0626	cystathionine gamma-synthase activity
DGM85_RS04070	COG0438	transferase activity, transferring glycosyl groups
DGM85_RS04090	COG0438	transferase activity, transferring glycosyl groups
DGM85_RS04095	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DGM85_RS04100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_RS04120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_RS04130	COG0277	FAD linked oxidase domain protein
DGM85_RS04135	COG0546	phosphoglycolate phosphatase activity
DGM85_RS04135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGM85_RS04150	COG2086	electron transfer activity
DGM85_RS04180	COG0662	Cupin 2, conserved barrel domain protein
DGM85_RS04180	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DGM85_RS04185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGM85_RS04215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGM85_RS04215	COG3218	ABC-type transport auxiliary lipoprotein component
DGM85_RS04220	COG1127	ABC transporter
DGM85_RS04225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGM85_RS04240	COG0442	prolyl-tRNA aminoacylation
DGM85_RS04250	COG1183	phosphatidylcholine synthase activity
DGM85_RS04275	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGM85_RS04280	COG1012	belongs to the aldehyde dehydrogenase family
DGM85_RS04285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGM85_RS04295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGM85_RS04310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGM85_RS04325	COG2205	protein histidine kinase activity
DGM85_RS04355	COG3791	Glutathione-dependent formaldehyde-activating
DGM85_RS04365	COG2801	Transposase and inactivated derivatives
DGM85_RS04375	COG1307	EDD domain protein, DegV family
DGM85_RS04400	COG0402	S-adenosylhomocysteine deaminase activity
DGM85_RS04405	COG3964	amidohydrolase
DGM85_RS04420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGM85_RS04425	COG0726	polysaccharide deacetylase
DGM85_RS04440	COG0436	Aminotransferase
DGM85_RS04445	COG1162	GTPase activity
DGM85_RS04470	COG2211	Major facilitator Superfamily
DGM85_RS04475	COG1609	Transcriptional regulator
DGM85_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS04485	COG2851	Citrate transporter
DGM85_RS04500	COG0642	Histidine kinase
DGM85_RS04510	COG2197	response regulator
DGM85_RS04525	COG0667	Aldo Keto reductase
DGM85_RS04530	COG0583	DNA-binding transcription factor activity
DGM85_RS04540	COG2801	Transposase and inactivated derivatives
DGM85_RS04565	COG1301	dicarboxylic acid transport
DGM85_RS04570	COG0280	phosphate acetyltransferase
DGM85_RS04570	COG0281	malic enzyme
DGM85_RS04595	COG1560	Kdo2-lipid A biosynthetic process
DGM85_RS04600	COG1519	Transferase
DGM85_RS04605	COG1538	Outer membrane efflux protein
DGM85_RS04610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGM85_RS04630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGM85_RS04635	COG0066	3-isopropylmalate dehydratase activity
DGM85_RS04640	COG0473	3-isopropylmalate dehydrogenase activity
DGM85_RS04645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGM85_RS04665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGM85_RS04670	COG0405	Gamma-glutamyltransferase
DGM85_RS04675	COG0840	transmembrane signaling receptor activity
DGM85_RS04685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGM85_RS04690	COG3710	Transcriptional regulator
DGM85_RS04710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGM85_RS04720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGM85_RS04735	COG0563	adenylate kinase activity
DGM85_RS04740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGM85_RS04750	COG3781	membrane
DGM85_RS04755	COG0671	phosphoesterase, PA-phosphatase related
DGM85_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS04770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM85_RS04775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGM85_RS04815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM85_RS04820	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DGM85_RS04830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGM85_RS04850	COG0352	thiamine-phosphate diphosphorylase activity
DGM85_RS04855	COG1773	rubredoxin
DGM85_RS04865	COG2912	Transglutaminase-like superfamily
DGM85_RS04885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGM85_RS04905	COG3079	Belongs to the UPF0149 family
DGM85_RS04910	COG0006	proline dipeptidase activity
DGM85_RS04920	COG0006	proline dipeptidase activity
DGM85_RS04935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGM85_RS04940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGM85_RS04950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGM85_RS04955	COG1561	YicC-like family, N-terminal region
DGM85_RS04970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGM85_RS04980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGM85_RS04985	COG1957	nucleoside hydrolase
DGM85_RS05005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGM85_RS05035	COG0714	Associated with various cellular activities
DGM85_RS05055	COG2304	oxidoreductase activity
DGM85_RS05065	COG1301	dicarboxylic acid transport
DGM85_RS05070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGM85_RS05085	COG4773	Receptor
DGM85_RS05090	COG0739	heme binding
DGM85_RS05095	COG1376	ErfK ybiS ycfS ynhG family protein
DGM85_RS05120	COG1022	Amp-dependent synthetase and ligase
DGM85_RS05155	COG0642	Histidine kinase
DGM85_RS05175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DGM85_RS05180	COG4149	molybdate abc transporter
DGM85_RS05185	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGM85_RS05190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM85_RS05190	COG3453	Protein conserved in bacteria
DGM85_RS05205	COG3047	cAMP biosynthetic process
DGM85_RS05215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGM85_RS05245	COG0126	phosphoglycerate kinase activity
DGM85_RS05255	COG0469	pyruvate kinase activity
DGM85_RS05260	COG3588	fructose-bisphosphate aldolase
DGM85_RS05265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGM85_RS05280	COG1648	precorrin-2 dehydrogenase activity
DGM85_RS05280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGM85_RS05295	COG2198	Histidine kinase
DGM85_RS05295	COG0784	Response regulator, receiver
DGM85_RS05295	COG2205	protein histidine kinase activity
DGM85_RS05315	COG0175	sulfate reduction
DGM85_RS05320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGM85_RS05325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGM85_RS05330	COG0175	sulfate reduction
DGM85_RS05335	COG0529	Catalyzes the synthesis of activated sulfate
DGM85_RS05335	COG2895	sulfate adenylyltransferase (ATP) activity
DGM85_RS05345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_RS05350	COG0308	aminopeptidase N
DGM85_RS05360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGM85_RS05370	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_RS05385	COG1609	Transcriptional regulator
DGM85_RS05395	COG1970	mechanosensitive ion channel activity
DGM85_RS05420	COG0471	metal ion transport
DGM85_RS05420	COG3273	potassium ion transport
DGM85_RS05425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGM85_RS05430	COG2022	thiamine diphosphate biosynthetic process
DGM85_RS05460	COG3039	Transposase
DGM85_RS05510	COG1002	Type II restriction enzyme, methylase subunits
DGM85_RS05515	COG1061	Type III restriction enzyme res subunit
DGM85_RS05520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGM85_RS05535	COG3328	transposase activity
DGM85_RS05550	COG3039	Transposase
DGM85_RS05570	COG3328	transposase activity
DGM85_RS05605	COG0322	excinuclease ABC activity
DGM85_RS05610	COG3328	transposase activity
DGM85_RS05640	COG2801	Transposase and inactivated derivatives
DGM85_RS05660	COG3328	transposase activity
DGM85_RS05675	COG0189	ligase activity
DGM85_RS05685	COG0745	RESPONSE REGULATOR receiver
DGM85_RS05710	COG0237	dephospho-CoA kinase activity
DGM85_RS05715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGM85_RS05760	COG0045	succinate-CoA ligase (ADP-forming) activity
DGM85_RS05765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DGM85_RS05780	COG3328	transposase activity
DGM85_RS05790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGM85_RS05790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM85_RS05800	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_RS05805	COG0564	pseudouridine synthase activity
DGM85_RS05820	COG3011	Protein conserved in bacteria
DGM85_RS05825	COG0840	transmembrane signaling receptor activity
DGM85_RS05845	COG3387	PFAM Glycoside hydrolase 15-related
DGM85_RS05850	COG1877	trehalose-phosphatase activity
DGM85_RS05895	COG0542	response to heat
DGM85_RS05905	COG4206	TonB-dependent receptor
DGM85_RS05930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGM85_RS05940	COG1492	cobalamin metabolic process
DGM85_RS05950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGM85_RS05970	COG3328	transposase activity
DGM85_RS05985	COG3328	transposase activity
DGM85_RS05995	COG0019	diaminopimelate decarboxylase activity
DGM85_RS06010	COG4264	IucA IucC family
DGM85_RS06020	COG4772	TonB-dependent receptor
DGM85_RS06045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGM85_RS06045	COG4651	solute:proton antiporter activity
DGM85_RS06075	COG0488	(ABC) transporter
DGM85_RS06095	COG2755	lipolytic protein G-D-S-L family
DGM85_RS06095	COG0657	acetylesterase activity
DGM85_RS06115	COG0477	Major facilitator Superfamily
DGM85_RS06130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DGM85_RS06145	COG0217	transcriptional regulatory protein
DGM85_RS06150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGM85_RS06155	COG0632	four-way junction helicase activity
DGM85_RS06160	COG3158	transport of potassium into the cell
DGM85_RS06170	COG2255	four-way junction helicase activity
DGM85_RS06175	COG0824	Thioesterase
DGM85_RS06185	COG0848	biopolymer transport protein
DGM85_RS06195	COG0823	Involved in the tonB-independent uptake of proteins
DGM85_RS06200	COG2885	chlorophyll binding
DGM85_RS06210	COG0602	queuosine metabolic process
DGM85_RS06220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGM85_RS06225	COG3920	Histidine kinase
DGM85_RS06245	COG3328	transposase activity
DGM85_RS06255	COG0840	transmembrane signaling receptor activity
DGM85_RS06295	COG0514	ATP-dependent DNA helicase (RecQ)
DGM85_RS06300	COG0783	Belongs to the Dps family
DGM85_RS06305	COG1643	Atp-dependent helicase
DGM85_RS06325	COG0837	glucose binding
DGM85_RS06340	COG0535	radical SAM domain protein
DGM85_RS06345	COG0535	radical SAM domain protein
DGM85_RS06350	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGM85_RS06355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGM85_RS06365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGM85_RS06375	COG1215	transferase activity, transferring glycosyl groups
DGM85_RS06380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGM85_RS06390	COG1199	ATP-dependent helicase activity
DGM85_RS06400	COG1397	ADP-ribosylglycohydrolase
DGM85_RS06410	COG0189	ligase activity
DGM85_RS06425	COG0835	chemotaxis
DGM85_RS06430	COG0840	transmembrane signaling receptor activity
DGM85_RS06435	COG0643	Histidine kinase
DGM85_RS06435	COG0784	Response regulator, receiver
DGM85_RS06435	COG2198	Histidine kinase
DGM85_RS06465	COG3142	Participates in the control of copper homeostasis
DGM85_RS06500	COG3537	Alpha-1,2-mannosidase
DGM85_RS06510	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM85_RS06520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGM85_RS06525	COG1388	LysM domain
DGM85_RS06525	COG3858	chitin binding
DGM85_RS06545	COG0837	glucose binding
DGM85_RS06550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGM85_RS06560	COG0494	nUDIX hydrolase
DGM85_RS06570	COG3956	TIGRFAM MazG family protein
DGM85_RS06575	COG1742	UPF0060 membrane protein
DGM85_RS06580	COG0330	HflC and HflK could
DGM85_RS06590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGM85_RS06595	COG0509	glycine decarboxylation via glycine cleavage system
DGM85_RS06620	COG3328	transposase activity
DGM85_RS06630	COG2801	Transposase and inactivated derivatives
DGM85_RS06665	COG3250	beta-galactosidase activity
DGM85_RS06670	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGM85_RS06690	COG1960	acyl-CoA dehydrogenase activity
DGM85_RS06720	COG0457	Tetratricopeptide repeat
DGM85_RS06730	COG0457	Tetratricopeptide repeat
DGM85_RS06740	COG1024	Enoyl-CoA hydratase
DGM85_RS06740	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGM85_RS06755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGM85_RS06760	COG0481	GTPase activity
DGM85_RS06775	COG0571	ribonuclease III activity
DGM85_RS06780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGM85_RS06785	COG1381	Involved in DNA repair and RecF pathway recombination
DGM85_RS06795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGM85_RS06800	COG2954	triphosphatase activity
DGM85_RS06805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DGM85_RS06810	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGM85_RS06815	COG3046	protein related to deoxyribodipyrimidine photolyase
DGM85_RS06820	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM85_RS06825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGM85_RS06830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGM85_RS06835	COG1278	Cold shock
DGM85_RS06840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_RS06850	COG1201	RNA secondary structure unwinding
DGM85_RS06855	COG1793	dna ligase
DGM85_RS06865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGM85_RS06865	COG1793	dna ligase
DGM85_RS06900	COG0183	Belongs to the thiolase family
DGM85_RS06920	COG1451	nucleotide metabolic process
DGM85_RS06925	COG5487	UPF0391 membrane protein
DGM85_RS06935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGM85_RS06955	COG1077	Cell shape determining protein MreB Mrl
DGM85_RS06960	COG1047	Peptidyl-prolyl cis-trans
DGM85_RS06970	COG2824	Alkylphosphonate utilization operon protein PhnA
DGM85_RS06980	COG1902	pentaerythritol trinitrate reductase activity
DGM85_RS06985	COG2814	Major facilitator Superfamily
DGM85_RS07020	COG0392	lysyltransferase activity
DGM85_RS07020	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGM85_RS07030	COG0251	oxidation-reduction process
DGM85_RS07035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGM85_RS07050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGM85_RS07075	COG1595	DNA-templated transcription, initiation
DGM85_RS07090	COG2878	Part of a membrane complex involved in electron transport
DGM85_RS07100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM85_RS07100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM85_RS07120	COG0346	lactoylglutathione lyase activity
DGM85_RS07135	COG0833	amino acid
DGM85_RS07140	COG2040	homocysteine
DGM85_RS07150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGM85_RS07170	COG1695	Transcriptional regulator
DGM85_RS07190	COG1981	membrane
DGM85_RS07205	COG0825	malonyl-CoA metabolic process
DGM85_RS07220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_RS07225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_RS07230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM85_RS07235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_RS07250	COG0750	zinc metalloprotease
DGM85_RS07255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGM85_RS07260	COG0575	Belongs to the CDS family
DGM85_RS07265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGM85_RS07270	COG0233	cytoplasmic translational termination
DGM85_RS07275	COG0528	UMP kinase activity
DGM85_RS07285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGM85_RS07290	COG0052	Belongs to the universal ribosomal protein uS2 family
DGM85_RS07340	COG1393	Belongs to the ArsC family
DGM85_RS07345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM85_RS07355	COG0367	asparagine synthase
DGM85_RS07365	COG4774	siderophore transport
DGM85_RS07385	COG3328	transposase activity
DGM85_RS07410	COG2801	Transposase and inactivated derivatives
DGM85_RS07415	COG3328	transposase activity
DGM85_RS07450	COG1566	PFAM secretion protein HlyD family protein
DGM85_RS07455	COG2814	Major facilitator Superfamily
DGM85_RS07485	COG3104	oligopeptide transport
DGM85_RS07515	COG0339	signal peptide processing
DGM85_RS07520	COG0386	Belongs to the glutathione peroxidase family
DGM85_RS07580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGM85_RS07585	COG0084	hydrolase, TatD family'
DGM85_RS07600	COG1960	acyl-CoA dehydrogenase activity
DGM85_RS07615	COG0367	asparagine synthase
DGM85_RS07625	COG0305	Participates in initiation and elongation during chromosome replication
DGM85_RS07630	COG0415	Belongs to the DNA photolyase family
DGM85_RS07645	COG0583	DNA-binding transcription factor activity
DGM85_RS07690	COG3706	GGDEF domain
DGM85_RS07715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGM85_RS07730	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_RS07740	COG0497	DNA recombination
DGM85_RS07745	COG1420	regulation of RNA biosynthetic process
DGM85_RS07750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGM85_RS07755	COG0443	Heat shock 70 kDa protein
DGM85_RS07760	COG0484	heat shock protein binding
DGM85_RS07765	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DGM85_RS07795	COG0583	DNA-binding transcription factor activity
DGM85_RS07800	COG1132	(ABC) transporter
DGM85_RS07835	COG2850	peptidyl-arginine hydroxylation
DGM85_RS07885	COG1131	(ABC) transporter
DGM85_RS07890	COG1725	Transcriptional regulator
DGM85_RS07900	COG0386	Belongs to the glutathione peroxidase family
DGM85_RS07915	COG2900	Belongs to the SlyX family
DGM85_RS07945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM85_RS07955	COG1410	methionine synthase
DGM85_RS07955	COG0646	methionine synthase
DGM85_RS07960	COG0646	methionine synthase
DGM85_RS07960	COG1410	methionine synthase
DGM85_RS07965	COG2226	methyltransferase
DGM85_RS07970	COG1960	acyl-CoA dehydrogenase activity
DGM85_RS07990	COG0557	exoribonuclease II activity
DGM85_RS08000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGM85_RS08010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGM85_RS08020	COG0704	Plays a role in the regulation of phosphate uptake
DGM85_RS08025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGM85_RS08030	COG0581	inorganic phosphate transmembrane transporter activity
DGM85_RS08035	COG0573	inorganic phosphate transmembrane transporter activity
DGM85_RS08040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGM85_RS08065	COG0659	secondary active sulfate transmembrane transporter activity
DGM85_RS08070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGM85_RS08080	COG1024	Enoyl-CoA hydratase
DGM85_RS08090	COG0494	nUDIX hydrolase
DGM85_RS08125	COG0488	(ABC) transporter
DGM85_RS08135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGM85_RS08135	COG0116	Belongs to the methyltransferase superfamily
DGM85_RS08140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGM85_RS08160	COG2925	Exonuclease
DGM85_RS08170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_RS08175	COG3844	kynureninase activity
DGM85_RS08185	COG0662	Cupin 2, conserved barrel domain protein
DGM85_RS08190	COG0288	reversible hydration of carbon dioxide
DGM85_RS08270	COG0017	Asparaginyl-tRNA synthetase
DGM85_RS08275	COG0316	Belongs to the HesB IscA family
DGM85_RS08280	COG0360	Binds together with S18 to 16S ribosomal RNA
DGM85_RS08285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGM85_RS08290	COG0359	binds to the 23S rRNA
DGM85_RS08300	COG3115	cell septum assembly
DGM85_RS08310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM85_RS08315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGM85_RS08320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGM85_RS08330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGM85_RS08340	COG4993	Dehydrogenase
DGM85_RS08350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGM85_RS08360	COG2986	histidine ammonia-lyase
DGM85_RS08365	COG1228	amidohydrolase
DGM85_RS08405	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGM85_RS08410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGM85_RS08415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGM85_RS08420	COG0077	Prephenate dehydratase
DGM85_RS08420	COG1605	Chorismate mutase
DGM85_RS08425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGM85_RS08440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGM85_RS08445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGM85_RS08450	COG0583	DNA-binding transcription factor activity
DGM85_RS08475	COG0840	transmembrane signaling receptor activity
DGM85_RS08495	COG0784	Response regulator, receiver
DGM85_RS08495	COG4191	Histidine kinase
DGM85_RS08500	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGM85_RS08520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_RS08530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGM85_RS08540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGM85_RS08555	COG1595	DNA-templated transcription, initiation
DGM85_RS08605	COG2244	polysaccharide biosynthetic process
DGM85_RS08635	COG2264	protein methyltransferase activity
DGM85_RS08645	COG0438	transferase activity, transferring glycosyl groups
DGM85_RS08660	COG1136	(ABC) transporter
DGM85_RS08675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGM85_RS08690	COG1253	flavin adenine dinucleotide binding
DGM85_RS08700	COG0306	phosphate transporter
DGM85_RS08725	COG0504	CTP synthase activity
DGM85_RS08730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DGM85_RS08740	COG0148	phosphopyruvate hydratase activity
DGM85_RS08745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DGM85_RS08755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGM85_RS08760	COG0585	pseudouridine synthase activity
DGM85_RS08765	COG2840	Smr protein MutS2
DGM85_RS08770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGM85_RS08775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGM85_RS08780	COG1238	metal cluster binding
DGM85_RS08790	COG3737	Protein of unknown function (DUF498/DUF598)
DGM85_RS08795	COG1534	Rna-binding protein
DGM85_RS08800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGM85_RS08810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGM85_RS08815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGM85_RS08825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGM85_RS08830	COG1546	Belongs to the CinA family
DGM85_RS08840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGM85_RS08845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGM85_RS08850	COG2137	regulation of response to DNA damage stimulus
DGM85_RS08855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGM85_RS08860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGM85_RS08875	COG1741	Belongs to the pirin family
DGM85_RS08880	COG0583	DNA-binding transcription factor activity
DGM85_RS08905	COG0351	phosphomethylpyrimidine kinase
DGM85_RS08920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGM85_RS08925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGM85_RS08940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGM85_RS08950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGM85_RS08955	COG3734	2-keto-3-deoxy-galactonokinase
DGM85_RS08965	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_RS08970	COG0800	Aldolase
DGM85_RS09005	COG1501	Belongs to the glycosyl hydrolase 31 family
DGM85_RS09015	COG1070	Carbohydrate kinase
DGM85_RS09020	COG2115	Belongs to the xylose isomerase family
DGM85_RS09025	COG0477	Major facilitator Superfamily
DGM85_RS09040	COG3328	transposase activity
DGM85_RS09045	COG1469	GTP cyclohydrolase I activity
DGM85_RS09070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGM85_RS09075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGM85_RS09080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGM85_RS09085	COG0166	Belongs to the GPI family
DGM85_RS09105	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM85_RS09115	COG3706	GGDEF domain
DGM85_RS09115	COG4251	negative regulation of phosphorylation
DGM85_RS09115	COG5001	Diguanylate cyclase
DGM85_RS09115	COG2203	Gaf domain
DGM85_RS09120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_RS09125	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGM85_RS09135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGM85_RS09140	COG0671	phosphoesterase, PA-phosphatase related
DGM85_RS09150	COG1794	racemase activity, acting on amino acids and derivatives
DGM85_RS09155	COG0697	spore germination
DGM85_RS09160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGM85_RS09165	COG0167	dihydroorotate dehydrogenase activity
DGM85_RS09180	COG1012	belongs to the aldehyde dehydrogenase family
DGM85_RS09215	COG1082	Xylose isomerase domain protein TIM barrel
DGM85_RS09225	COG2211	Major facilitator Superfamily
DGM85_RS09240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGM85_RS09245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGM85_RS09260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGM85_RS09265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM85_RS09265	COG0072	phenylalanine-tRNA ligase activity
DGM85_RS09315	COG0438	transferase activity, transferring glycosyl groups
DGM85_RS09320	COG0438	transferase activity, transferring glycosyl groups
DGM85_RS09330	COG0438	transferase activity, transferring glycosyl groups
DGM85_RS09355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_RS09365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_RS09385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGM85_RS09395	COG1960	acyl-CoA dehydrogenase activity
DGM85_RS09405	COG3040	lipid binding
DGM85_RS09420	COG0322	excinuclease ABC activity
DGM85_RS09435	COG0784	Response regulator, receiver
DGM85_RS09435	COG4191	Histidine kinase
DGM85_RS09455	COG1194	a g-specific adenine glycosylase
DGM85_RS09460	COG0552	protein localization to endoplasmic reticulum
DGM85_RS09470	COG3938	Belongs to the proline racemase family
DGM85_RS09475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_RS09490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGM85_RS09500	COG0006	proline dipeptidase activity
DGM85_RS09515	COG0531	amino acid
DGM85_RS09620	COG3328	transposase activity
DGM85_RS09630	COG0460	homoserine dehydrogenase
DGM85_RS09630	COG0527	aspartate kinase activity
DGM85_RS09665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM85_RS09670	COG0124	histidyl-tRNA synthetase
DGM85_RS09680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGM85_RS09685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGM85_RS09690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM85_RS09695	COG0131	Imidazoleglycerol-phosphate dehydratase
DGM85_RS09695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGM85_RS09700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGM85_RS09705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGM85_RS09710	COG0107	imidazoleglycerol-phosphate synthase activity
DGM85_RS09715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGM85_RS09715	COG0140	phosphoribosyl-ATP diphosphatase activity
DGM85_RS09730	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DGM85_RS09735	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DGM85_RS09740	COG0235	Class ii aldolase
DGM85_RS09745	COG0531	amino acid
DGM85_RS09750	COG0531	amino acid
DGM85_RS09760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGM85_RS09765	COG0277	FAD linked oxidase domain protein
DGM85_RS09785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGM85_RS09830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGM85_RS09835	COG2258	MOSC domain
DGM85_RS09840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DGM85_RS09845	COG0505	Belongs to the CarA family
DGM85_RS09855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGM85_RS09860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM85_RS09870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGM85_RS09890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DGM85_RS09900	COG2205	protein histidine kinase activity
DGM85_RS09900	COG2198	Histidine kinase
DGM85_RS09900	COG0784	Response regulator, receiver
DGM85_RS09905	COG2205	protein histidine kinase activity
DGM85_RS09905	COG0784	Response regulator, receiver
DGM85_RS09905	COG2198	Histidine kinase
DGM85_RS09910	COG1024	Enoyl-CoA hydratase
DGM85_RS09915	COG0318	PFAM AMP-dependent synthetase and ligase
DGM85_RS09950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_RS09960	COG2201	protein-glutamate methylesterase activity
DGM85_RS09965	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DGM85_RS09975	COG0840	transmembrane signaling receptor activity
DGM85_RS09985	COG0835	chemotaxis
DGM85_RS09995	COG0840	transmembrane signaling receptor activity
DGM85_RS10000	COG0840	transmembrane signaling receptor activity
DGM85_RS10005	COG0840	transmembrane signaling receptor activity
DGM85_RS10010	COG0840	transmembrane signaling receptor activity
DGM85_RS10015	COG0840	transmembrane signaling receptor activity
DGM85_RS10030	COG0840	transmembrane signaling receptor activity
DGM85_RS10035	COG0840	transmembrane signaling receptor activity
DGM85_RS10040	COG0840	transmembrane signaling receptor activity
DGM85_RS10045	COG0840	transmembrane signaling receptor activity
DGM85_RS10055	COG0840	transmembrane signaling receptor activity
DGM85_RS10070	COG0840	transmembrane signaling receptor activity
DGM85_RS10075	COG0840	transmembrane signaling receptor activity
DGM85_RS10085	COG0745	RESPONSE REGULATOR receiver
DGM85_RS10095	COG0835	chemotaxis
DGM85_RS10100	COG1192	Involved in chromosome partitioning
DGM85_RS10105	COG1360	Flagellar Motor Protein
DGM85_RS10110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGM85_RS10145	COG0643	Histidine kinase
DGM85_RS10145	COG0784	Response regulator, receiver
DGM85_RS10145	COG2198	Histidine kinase
DGM85_RS10175	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGM85_RS10195	COG3039	Transposase
DGM85_RS10205	COG1684	flagellar biosynthetic protein fliR
DGM85_RS10220	COG3190	flagellar
DGM85_RS10270	COG1677	Flagellar hook-basal body complex protein FliE
DGM85_RS10290	COG3328	transposase activity
DGM85_RS10305	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGM85_RS10315	COG3328	transposase activity
DGM85_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS10350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_RS10370	COG2201	protein-glutamate methylesterase activity
DGM85_RS10400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGM85_RS10410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGM85_RS10420	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGM85_RS10420	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGM85_RS10425	COG1706	bacterial-type flagellum-dependent cell motility
DGM85_RS10430	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGM85_RS10440	COG4787	bacterial-type flagellum-dependent cell motility
DGM85_RS10450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGM85_RS10455	COG1558	bacterial-type flagellum-dependent cell motility
DGM85_RS10465	COG0784	Response regulator, receiver
DGM85_RS10465	COG0835	chemotaxis
DGM85_RS10485	COG5002	protein histidine kinase activity
DGM85_RS10495	COG4585	Histidine kinase
DGM85_RS10515	COG2915	High frequency lysogenization protein hflD homolog
DGM85_RS10520	COG0482	sulfurtransferase activity
DGM85_RS10540	COG0542	response to heat
DGM85_RS10550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGM85_RS10560	COG0492	ferredoxin-NADP+ reductase activity
DGM85_RS10565	COG1674	ftsk spoiiie
DGM85_RS10575	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DGM85_RS10585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGM85_RS10590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGM85_RS10595	COG0183	Belongs to the thiolase family
DGM85_RS10600	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGM85_RS10600	COG1024	Enoyl-CoA hydratase
DGM85_RS10615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGM85_RS10635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_RS10640	COG1160	GTP binding
DGM85_RS10645	COG0303	'Molybdopterin
DGM85_RS10650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGM85_RS10685	COG3328	transposase activity
DGM85_RS10700	COG0708	Exodeoxyribonuclease III
DGM85_RS10710	COG0303	'Molybdopterin
DGM85_RS10715	COG0746	molybdenum cofactor guanylyltransferase activity
DGM85_RS10740	COG1648	precorrin-2 dehydrogenase activity
DGM85_RS10740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGM85_RS10750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGM85_RS10755	COG2223	nitrite transmembrane transporter activity
DGM85_RS10760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGM85_RS10770	COG0243	molybdopterin cofactor binding
DGM85_RS10790	COG3685	Protein conserved in bacteria
DGM85_RS10810	COG5001	Diguanylate cyclase
DGM85_RS10820	COG4566	intracellular signal transduction
DGM85_RS10875	COG1238	metal cluster binding
DGM85_RS10895	COG3328	transposase activity
DGM85_RS10945	COG0800	Aldolase
DGM85_RS10950	COG0129	dihydroxy-acid dehydratase activity
DGM85_RS10955	COG0363	glucosamine-6-phosphate deaminase activity
DGM85_RS10960	COG0837	glucose binding
DGM85_RS10965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGM85_RS10975	COG0354	folic acid binding
DGM85_RS10990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGM85_RS11005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGM85_RS11010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGM85_RS11020	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGM85_RS11025	COG1136	(ABC) transporter
DGM85_RS11040	COG0811	peptide transport
DGM85_RS11050	COG1132	(ABC) transporter
DGM85_RS11055	COG1663	tetraacyldisaccharide 4'-kinase activity
DGM85_RS11060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGM85_RS11065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGM85_RS11075	COG0322	excinuclease ABC activity
DGM85_RS11080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGM85_RS11105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGM85_RS11125	COG1054	Belongs to the UPF0176 family
DGM85_RS11135	COG3328	transposase activity
DGM85_RS11140	COG3039	Transposase
DGM85_RS11155	COG3064	Membrane
DGM85_RS11160	COG0428	transporter
DGM85_RS11170	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGM85_RS11210	COG0640	Transcriptional regulator
DGM85_RS11325	COG3328	transposase activity
DGM85_RS11345	COG0784	Response regulator, receiver
DGM85_RS11345	COG2205	protein histidine kinase activity
DGM85_RS11350	COG2183	response to ionizing radiation
DGM85_RS11360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_RS11360	COG0723	plastoquinol--plastocyanin reductase activity
DGM85_RS11375	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGM85_RS11385	COG1183	phosphatidylcholine synthase activity
DGM85_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS11405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DGM85_RS11420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DGM85_RS11435	COG1914	H( )-stimulated, divalent metal cation uptake system
DGM85_RS11455	COG2814	Major facilitator Superfamily
DGM85_RS11470	COG1335	isochorismatase
DGM85_RS11485	COG2197	response regulator
DGM85_RS11515	COG0583	DNA-binding transcription factor activity
DGM85_RS11520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGM85_RS11525	COG3002	Belongs to the UPF0753 family
DGM85_RS11535	COG0604	alcohol dehydrogenase
DGM85_RS11540	COG3384	dioxygenase
DGM85_RS11550	COG2801	Transposase and inactivated derivatives
DGM85_RS11555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DGM85_RS11565	COG3328	transposase activity
DGM85_RS11595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGM85_RS11595	COG0519	Catalyzes the synthesis of GMP from XMP
DGM85_RS11605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGM85_RS11615	COG0475	glutathione-regulated potassium exporter activity
DGM85_RS11615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGM85_RS11620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGM85_RS11630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGM85_RS11635	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGM85_RS11645	COG0776	regulation of translation
DGM85_RS11650	COG0539	negative regulation of cytoplasmic translation
DGM85_RS11655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGM85_RS11670	COG2957	Belongs to the agmatine deiminase family
DGM85_RS11675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM85_RS11700	COG0395	ABC-type sugar transport system, permease component
DGM85_RS11705	COG1175	transmembrane transport
DGM85_RS11735	COG2350	Protein conserved in bacteria
DGM85_RS11740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGM85_RS11745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGM85_RS11750	COG1187	pseudouridine synthase activity
DGM85_RS11765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM85_RS11770	COG0436	Aminotransferase
DGM85_RS11775	COG4133	protoheme IX ABC transporter activity
DGM85_RS11795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGM85_RS11820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_RS11830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGM85_RS11835	COG4988	ABC transporter
DGM85_RS11845	COG1294	oxidase, subunit
DGM85_RS11875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGM85_RS11880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGM85_RS11890	COG0165	Argininosuccinate lyase
DGM85_RS11895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGM85_RS11905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGM85_RS11910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM85_RS11920	COG0137	argininosuccinate synthase activity
DGM85_RS11925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGM85_RS11935	COG0215	cysteine-tRNA ligase activity
DGM85_RS11940	COG2166	iron-sulfur cluster assembly
DGM85_RS11955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DGM85_RS11960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGM85_RS11975	COG3328	transposase activity
DGM85_RS11990	COG4302	ethanolamine ammonia-lyase activity
DGM85_RS12020	COG3039	Transposase
DGM85_RS12050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGM85_RS12055	COG0402	S-adenosylhomocysteine deaminase activity
DGM85_RS12065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGM85_RS12070	COG1509	lysine 2,3-aminomutase activity
DGM85_RS12075	COG3300	MHYT domain
DGM85_RS12075	COG5001	Diguanylate cyclase
DGM85_RS12090	COG0483	inositol monophosphate 1-phosphatase activity
DGM85_RS12095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGM85_RS12110	COG0488	(ABC) transporter
DGM85_RS12115	COG0513	Belongs to the DEAD box helicase family
DGM85_RS12120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGM85_RS12125	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGM85_RS12150	COG3328	transposase activity
DGM85_RS12160	COG0625	glutathione transferase activity
DGM85_RS12170	COG4681	YaeQ
DGM85_RS12175	COG2081	HI0933 family
DGM85_RS12185	COG0501	Belongs to the peptidase M48B family
DGM85_RS12190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM85_RS12195	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS12220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGM85_RS12225	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGM85_RS12230	COG0802	atpase or kinase
DGM85_RS12235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGM85_RS12235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGM85_RS12240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGM85_RS12245	COG1570	exodeoxyribonuclease VII activity
DGM85_RS12255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGM85_RS12300	COG0835	chemotaxis
DGM85_RS12305	COG0840	transmembrane signaling receptor activity
DGM85_RS12335	COG2969	positive regulation of protein catabolic process
DGM85_RS12340	COG0625	glutathione transferase activity
DGM85_RS12345	COG2857	Cytochrome c1
DGM85_RS12350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGM85_RS12355	COG0723	plastoquinol--plastocyanin reductase activity
DGM85_RS12360	COG0741	lytic transglycosylase activity
DGM85_RS12375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGM85_RS12380	COG1702	phosphate starvation-inducible protein PhoH
DGM85_RS12390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DGM85_RS12400	COG4535	Mg2 and Co2 transporter CorC
DGM85_RS12415	COG1012	belongs to the aldehyde dehydrogenase family
DGM85_RS12420	COG1177	transmembrane transport
DGM85_RS12425	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGM85_RS12430	COG3842	ATPase activity
DGM85_RS12450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGM85_RS12470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DGM85_RS12475	COG0174	glutamine synthetase
DGM85_RS12480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_RS12490	COG2703	oxygen carrier activity
DGM85_RS12495	COG0477	Major facilitator Superfamily
DGM85_RS12505	COG0243	molybdopterin cofactor binding
DGM85_RS12510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DGM85_RS12515	COG2223	nitrite transmembrane transporter activity
DGM85_RS12520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGM85_RS12530	COG2733	membrane
DGM85_RS12535	COG0784	Response regulator, receiver
DGM85_RS12535	COG2205	protein histidine kinase activity
DGM85_RS12535	COG5002	protein histidine kinase activity
DGM85_RS12545	COG0477	Major facilitator Superfamily
DGM85_RS12580	COG2902	Dehydrogenase
DGM85_RS12590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_RS12595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_RS12600	COG1609	Transcriptional regulator
DGM85_RS12605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGM85_RS12605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM85_RS12610	COG1105	Belongs to the carbohydrate kinase PfkB family
DGM85_RS12615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGM85_RS12615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGM85_RS12630	COG3328	transposase activity
DGM85_RS12645	COG3328	transposase activity
DGM85_RS12650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGM85_RS12660	COG1862	Preprotein translocase
DGM85_RS12665	COG0343	queuine tRNA-ribosyltransferase activity
DGM85_RS12670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DGM85_RS12705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DGM85_RS12710	COG3291	Pkd domain containing protein
DGM85_RS12715	COG0405	Gamma-glutamyltransferase
DGM85_RS12720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGM85_RS12730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGM85_RS12735	COG0742	ribosomal rna small subunit methyltransferase
DGM85_RS12740	COG0326	Molecular chaperone. Has ATPase activity
DGM85_RS12805	COG3702	type iv secretory pathway
DGM85_RS12825	COG2948	multi-organism process
DGM85_RS12845	COG3505	Type IV secretory pathway VirD4
DGM85_RS12860	COG0556	nucleotide-excision repair
DGM85_RS12965	COG4695	Portal protein
DGM85_RS13010	COG3179	chitinase
DGM85_RS13140	COG3275	phosphorelay sensor kinase activity
DGM85_RS13145	COG1611	Belongs to the LOG family
DGM85_RS13155	COG2095	MarC family integral membrane protein
DGM85_RS13165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGM85_RS13200	COG1185	polyribonucleotide nucleotidyltransferase activity
DGM85_RS13205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGM85_RS13210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGM85_RS13215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGM85_RS13220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGM85_RS13225	COG0195	Participates in both transcription termination and antitermination
DGM85_RS13230	COG0779	Required for maturation of 30S ribosomal subunits
DGM85_RS13240	COG1007	ATP synthesis coupled electron transport
DGM85_RS13265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_RS13270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGM85_RS13280	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGM85_RS13285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGM85_RS13290	COG0649	NAD binding
DGM85_RS13295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_RS13300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_RS13305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_RS13320	COG0149	triose-phosphate isomerase activity
DGM85_RS13325	COG4221	oxidoreductase activity
DGM85_RS13355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGM85_RS13360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGM85_RS13365	COG0159	tryptophan synthase activity
DGM85_RS13375	COG0133	tryptophan synthase activity
DGM85_RS13385	COG0135	phosphoribosylanthranilate isomerase activity
DGM85_RS13390	COG0101	tRNA pseudouridine synthase activity
DGM85_RS13405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGM85_RS13410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGM85_RS13415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DGM85_RS13420	COG2890	protein-(glutamine-N5) methyltransferase activity
DGM85_RS13430	COG0688	phosphatidylethanolamine metabolic process
DGM85_RS13440	COG0433	COG0433 Predicted ATPase
DGM85_RS13465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM85_RS13470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGM85_RS13495	COG0717	Belongs to the dCTP deaminase family
DGM85_RS13500	COG0489	protein tyrosine kinase activity
DGM85_RS13530	COG3590	peptidase
DGM85_RS13555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGM85_RS13560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_RS13565	COG2311	Membrane
DGM85_RS13570	COG1047	Peptidyl-prolyl cis-trans
DGM85_RS13575	COG0791	NLP P60 protein
DGM85_RS13580	COG0791	NLP P60 protein
DGM85_RS13590	COG4106	trans-aconitate 2-methyltransferase activity
DGM85_RS13595	COG1301	dicarboxylic acid transport
DGM85_RS13600	COG1785	Belongs to the alkaline phosphatase family
DGM85_RS13605	COG0037	tRNA processing
DGM85_RS13610	COG1722	exodeoxyribonuclease VII activity
DGM85_RS13615	COG0142	geranyltranstransferase activity
DGM85_RS13620	COG4104	PAAR repeat-containing protein
DGM85_RS13630	COG0312	modulator of DNA gyrase
DGM85_RS13635	COG3028	Belongs to the UPF0307 family
DGM85_RS13640	COG0312	modulator of DNA gyrase
DGM85_RS13650	COG3164	Protein of unknown function
DGM85_RS13660	COG0424	maF-like protein
DGM85_RS13665	COG2968	Membrane
DGM85_RS13680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGM85_RS13695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGM85_RS13710	COG0495	leucyl-tRNA aminoacylation
DGM85_RS13720	COG3118	belongs to the thioredoxin family
DGM85_RS13745	COG2155	Conserved Protein
DGM85_RS13800	COG1132	(ABC) transporter
DGM85_RS13830	COG0745	RESPONSE REGULATOR receiver
DGM85_RS13835	COG5000	phosphorelay sensor kinase activity
DGM85_RS13835	COG5002	protein histidine kinase activity
DGM85_RS13840	COG0475	glutathione-regulated potassium exporter activity
DGM85_RS13850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGM85_RS13870	COG1187	pseudouridine synthase activity
DGM85_RS13875	COG5002	protein histidine kinase activity
DGM85_RS13875	COG5001	Diguanylate cyclase
DGM85_RS13885	COG1595	DNA-templated transcription, initiation
DGM85_RS14000	COG0667	Aldo Keto reductase
DGM85_RS14005	COG2814	Major facilitator Superfamily
DGM85_RS14010	COG0583	DNA-binding transcription factor activity
DGM85_RS14020	COG2207	Transcriptional regulator
DGM85_RS14030	COG1309	transcriptional regulator
DGM85_RS14040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_RS14055	COG0735	belongs to the Fur family
DGM85_RS14060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM85_RS14085	COG4452	Inner membrane protein CreD
DGM85_RS14100	COG2205	protein histidine kinase activity
DGM85_RS14105	COG0745	RESPONSE REGULATOR receiver
DGM85_RS14110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGM85_RS14125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGM85_RS14135	COG0643	Histidine kinase
DGM85_RS14135	COG2198	Histidine kinase
DGM85_RS14140	COG0840	transmembrane signaling receptor activity
DGM85_RS14145	COG0835	chemotaxis
DGM85_RS14150	COG2202	Pas domain
DGM85_RS14150	COG2200	EAL domain
DGM85_RS14150	COG2199	diguanylate cyclase activity
DGM85_RS14155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGM85_RS14160	COG2201	protein-glutamate methylesterase activity
DGM85_RS14170	COG3590	peptidase
DGM85_RS14185	COG1515	deoxyribonuclease V activity
DGM85_RS14195	COG1741	Belongs to the pirin family
DGM85_RS14210	COG1741	Belongs to the pirin family
DGM85_RS14215	COG1966	Carbon starvation protein
DGM85_RS14220	COG2879	small protein
DGM85_RS14260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DGM85_RS14265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGM85_RS14270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGM85_RS14275	COG2080	2 iron, 2 sulfur cluster binding
DGM85_RS14280	COG0604	alcohol dehydrogenase
DGM85_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS14280	COG3321	synthase
DGM85_RS14285	COG5001	Diguanylate cyclase
DGM85_RS14285	COG3706	GGDEF domain
DGM85_RS14285	COG4251	negative regulation of phosphorylation
DGM85_RS14285	COG2203	Gaf domain
DGM85_RS14290	COG0629	single-stranded DNA binding
DGM85_RS14295	COG0142	geranyltranstransferase activity
DGM85_RS14305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DGM85_RS14320	COG0527	aspartate kinase activity
DGM85_RS14325	COG0384	phenazine biosynthesis protein PhzF
DGM85_RS14330	COG0384	phenazine biosynthesis protein PhzF
DGM85_RS14340	COG1764	response to oxidative stress
DGM85_RS14345	COG0540	Belongs to the ATCase OTCase family
DGM85_RS14350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGM85_RS14355	COG1678	Uncharacterized ACR, COG1678
DGM85_RS14360	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DGM85_RS14365	COG0519	Catalyzes the synthesis of GMP from XMP
DGM85_RS14390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGM85_RS14405	COG0739	heme binding
DGM85_RS14425	COG0693	protein deglycase activity
DGM85_RS14435	COG1959	2 iron, 2 sulfur cluster binding
DGM85_RS14440	COG0719	Fe-S assembly protein
DGM85_RS14445	COG0396	ATPase activity
DGM85_RS14450	COG0719	Fe-S assembly protein
DGM85_RS14455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGM85_RS14460	COG0456	acetyltransferase
DGM85_RS14465	COG2146	nitrite reductase [NAD(P)H] activity
DGM85_RS14470	COG4774	siderophore transport
DGM85_RS14475	COG3128	pkhd-type hydroxylase
DGM85_RS14500	COG1477	protein flavinylation
DGM85_RS14505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGM85_RS14515	COG3328	transposase activity
DGM85_RS14520	COG1555	photosystem II stabilization
DGM85_RS14525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM85_RS14540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGM85_RS14550	COG0628	permease
DGM85_RS14560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGM85_RS14575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGM85_RS14595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DGM85_RS14600	COG0271	Belongs to the BolA IbaG family
DGM85_RS14610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGM85_RS14620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGM85_RS14625	COG1137	ATPase activity
DGM85_RS14640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM85_RS14645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DGM85_RS14650	COG1660	Displays ATPase and GTPase activities
DGM85_RS14660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM85_RS14665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGM85_RS14675	COG2239	Acts as a magnesium transporter
DGM85_RS14685	COG1294	oxidase, subunit
DGM85_RS14735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGM85_RS14735	COG0551	DNA topoisomerase type I activity
DGM85_RS14750	COG2951	lytic endotransglycosylase activity
DGM85_RS14815	COG1271	oxidase subunit
DGM85_RS14825	COG1113	amino acid transport
DGM85_RS14835	COG2801	Transposase and inactivated derivatives
DGM85_RS14840	COG3328	transposase activity
DGM85_RS14870	COG2197	response regulator
DGM85_RS14875	COG0531	amino acid
DGM85_RS14935	COG2814	Major facilitator Superfamily
DGM85_RS14940	COG0754	glutathionylspermidine amidase activity
DGM85_RS14965	COG1842	Phage shock protein A
DGM85_RS14975	COG0259	pyridoxamine-phosphate oxidase activity
DGM85_RS14980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGM85_RS14985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGM85_RS14995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGM85_RS15000	COG2814	Major facilitator Superfamily
DGM85_RS15030	COG2353	YceI-like domain
DGM85_RS15050	COG1760	l-serine dehydratase
DGM85_RS15060	COG0527	aspartate kinase activity
DGM85_RS15060	COG0460	homoserine dehydrogenase
DGM85_RS15065	COG0626	cystathionine gamma-synthase activity
DGM85_RS15070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_RS15075	COG0739	heme binding
DGM85_RS15080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGM85_RS15085	COG1272	protein, Hemolysin III
DGM85_RS15090	COG2982	Protein involved in outer membrane biogenesis
DGM85_RS15095	COG0516	GMP reductase activity
DGM85_RS15095	COG0517	IMP dehydrogenase activity
DGM85_RS15100	COG0463	Glycosyl transferase, family 2
DGM85_RS15105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGM85_RS15110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGM85_RS15120	COG4771	TonB-dependent receptor
DGM85_RS15125	COG1309	transcriptional regulator
DGM85_RS15135	COG1960	acyl-CoA dehydrogenase activity
DGM85_RS15165	COG2801	Transposase and inactivated derivatives
DGM85_RS15170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGM85_RS15180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGM85_RS15205	COG0534	Mate efflux family protein
DGM85_RS15210	COG0335	large ribosomal subunit rRNA binding
DGM85_RS15215	COG0336	Belongs to the RNA methyltransferase TrmD family
DGM85_RS15220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DGM85_RS15225	COG0228	four-way junction DNA binding
DGM85_RS15230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGM85_RS15240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGM85_RS15265	COG4191	Histidine kinase
DGM85_RS15265	COG0784	Response regulator, receiver
DGM85_RS15270	COG2205	protein histidine kinase activity
DGM85_RS15270	COG3437	response regulator, receiver
DGM85_RS15270	COG3850	Histidine kinase
DGM85_RS15270	COG4999	Histidine kinase
DGM85_RS15275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGM85_RS15285	COG2205	protein histidine kinase activity
DGM85_RS15290	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGM85_RS15300	COG4771	TonB-dependent receptor
DGM85_RS15325	COG2172	sigma factor antagonist activity
DGM85_RS15330	COG1366	Belongs to the anti-sigma-factor antagonist family
DGM85_RS15335	COG1366	Belongs to the anti-sigma-factor antagonist family
DGM85_RS15360	COG2207	Transcriptional regulator
DGM85_RS15370	COG3152	Membrane
DGM85_RS15385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGM85_RS15390	COG1845	cytochrome c oxidase, subunit III
DGM85_RS15395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGM85_RS15410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGM85_RS15415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGM85_RS15420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGM85_RS15425	COG0196	riboflavin kinase activity
DGM85_RS15435	COG0268	Binds directly to 16S ribosomal RNA
DGM85_RS15440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGM85_RS15445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGM85_RS15450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DGM85_RS15455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGM85_RS15460	COG0824	Thioesterase
DGM85_RS15475	COG1946	Acyl-CoA thioesterase
DGM85_RS15485	COG1595	DNA-templated transcription, initiation
DGM85_RS15500	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGM85_RS15510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DGM85_RS15535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGM85_RS15550	COG2197	response regulator
DGM85_RS15555	COG4585	Histidine kinase
DGM85_RS15565	COG0850	regulation of cytokinetic process
DGM85_RS15570	COG2894	cell division
DGM85_RS15575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGM85_RS15585	COG0642	Histidine kinase
DGM85_RS15590	COG0745	RESPONSE REGULATOR receiver
DGM85_RS15605	COG2194	sulfuric ester hydrolase activity
DGM85_RS15635	COG2814	Major facilitator Superfamily
DGM85_RS15660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGM85_RS15660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGM85_RS15670	COG0656	L-ascorbic acid biosynthetic process
DGM85_RS15675	COG0753	catalase activity
DGM85_RS15690	COG1917	Cupin 2, conserved barrel domain protein
DGM85_RS15690	COG2207	Transcriptional regulator
DGM85_RS15720	COG0823	Involved in the tonB-independent uptake of proteins
DGM85_RS15720	COG1506	peptidase
DGM85_RS15745	COG1297	OPT oligopeptide transporter protein
DGM85_RS15765	COG0587	DNA-directed DNA polymerase activity
DGM85_RS15780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGM85_RS15815	COG2080	2 iron, 2 sulfur cluster binding
DGM85_RS15820	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGM85_RS15825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGM85_RS15855	COG0492	ferredoxin-NADP+ reductase activity
DGM85_RS15875	COG3537	Alpha-1,2-mannosidase
DGM85_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS15885	COG3387	PFAM Glycoside hydrolase 15-related
DGM85_RS15955	COG1309	transcriptional regulator
DGM85_RS15960	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS15970	COG0308	aminopeptidase N
DGM85_RS15975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGM85_RS15985	COG0330	HflC and HflK could
DGM85_RS15990	COG0330	HflC and HflK could
DGM85_RS16010	COG0678	peroxiredoxin activity
DGM85_RS16020	COG4953	penicillin-binding protein 1C
DGM85_RS16025	COG3852	Histidine kinase
DGM85_RS16045	COG2373	Large extracellular alpha-helical protein
DGM85_RS16075	COG3328	transposase activity
DGM85_RS16095	COG3829	transcription factor binding
DGM85_RS16125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGM85_RS16130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGM85_RS16145	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS16160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_RS16165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DGM85_RS16170	COG1399	metal-binding, possibly nucleic acid-binding protein
DGM85_RS16175	COG0424	maF-like protein
DGM85_RS16185	COG0714	Associated with various cellular activities
DGM85_RS16205	COG0537	adenosine 5'-monophosphoramidase activity
DGM85_RS16210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGM85_RS16215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGM85_RS16235	COG0314	molybdopterin synthase activity
DGM85_RS16240	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGM85_RS16245	COG0315	cyclic pyranopterin monophosphate synthase activity
DGM85_RS16255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGM85_RS16260	COG1234	tRNA 3'-trailer cleavage
DGM85_RS16265	COG3642	lipopolysaccharide core region biosynthetic process
DGM85_RS16270	COG0859	PFAM glycosyl transferase family 9
DGM85_RS16295	COG0631	protein serine/threonine phosphatase activity
DGM85_RS16300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGM85_RS16305	COG0328	RNA-DNA hybrid ribonuclease activity
DGM85_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM85_RS16325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM85_RS16355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGM85_RS16365	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGM85_RS16380	COG3328	transposase activity
DGM85_RS16420	COG0473	3-isopropylmalate dehydrogenase activity
DGM85_RS16435	COG4783	chaperone-mediated protein folding
DGM85_RS16450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGM85_RS16460	COG0438	transferase activity, transferring glycosyl groups
DGM85_RS16465	COG0671	phosphoesterase, PA-phosphatase related
DGM85_RS16470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_RS16480	COG3291	Pkd domain containing protein
DGM85_RS16485	COG2833	Protein of unknown function (DUF455)
DGM85_RS16505	COG0285	dihydrofolate synthase activity
DGM85_RS16515	COG0406	alpha-ribazole phosphatase activity
DGM85_RS16545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGM85_RS16550	COG4208	sulfate ABC transporter
DGM85_RS16555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGM85_RS16560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DGM85_RS16565	COG0156	8-amino-7-oxononanoate synthase activity
DGM85_RS16585	COG2885	chlorophyll binding
DGM85_RS16595	COG3328	transposase activity
DGM85_RS16605	COG0604	alcohol dehydrogenase
DGM85_RS16610	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGM85_RS16610	COG1902	pentaerythritol trinitrate reductase activity
DGM85_RS16625	COG0625	glutathione transferase activity
DGM85_RS16630	COG0039	L-malate dehydrogenase activity
DGM85_RS16635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGM85_RS16640	COG1217	gtp-binding protein TYPA
DGM85_RS16650	COG0154	amidase activity
DGM85_RS16660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGM85_RS16680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DGM85_RS16685	COG0203	ribosomal protein L17
DGM85_RS16710	COG0201	protein transport
DGM85_RS16715	COG0200	Binds to the 23S rRNA
DGM85_RS16720	COG1841	ribosomal large subunit assembly
DGM85_RS16730	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DGM85_RS16735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGM85_RS16740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DGM85_RS16750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DGM85_RS16755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGM85_RS16765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DGM85_RS16770	COG0255	Belongs to the universal ribosomal protein uL29 family
DGM85_RS16775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGM85_RS16780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DGM85_RS16790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DGM85_RS16795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGM85_RS16800	COG0089	rRNA binding
DGM85_RS16805	COG0088	Forms part of the polypeptide exit tunnel
DGM85_RS16810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGM85_RS16815	COG0051	transcription antitermination factor activity, RNA binding
DGM85_RS16820	COG3328	transposase activity
DGM85_RS16840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGM85_RS16845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGM85_RS16850	COG0049	tRNA binding
DGM85_RS16855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGM85_RS16860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGM85_RS16865	COG0085	RNA polymerase activity
DGM85_RS16875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGM85_RS16880	COG0081	regulation of translation
DGM85_RS16885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGM85_RS16890	COG0250	Participates in transcription elongation, termination and antitermination
DGM85_RS16905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGM85_RS16925	COG0012	GTP binding
DGM85_RS16930	COG0193	aminoacyl-tRNA hydrolase activity
DGM85_RS16935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGM85_RS16940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGM85_RS16950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DGM85_RS16955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGM85_RS16965	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGM85_RS16970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGM85_RS16980	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGM85_RS16995	COG1254	Belongs to the acylphosphatase family
DGM85_RS17000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_RS17005	COG1295	ribonuclease BN
DGM85_RS17030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGM85_RS17035	COG1404	Belongs to the peptidase S8 family
DGM85_RS17040	COG1404	Belongs to the peptidase S8 family
DGM85_RS17045	COG1404	Belongs to the peptidase S8 family
DGM85_RS17050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGM85_RS17105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGM85_RS17105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGM85_RS17125	COG2890	protein-(glutamine-N5) methyltransferase activity
DGM85_RS17135	COG3634	alkyl hydroperoxide reductase activity
DGM85_RS17140	COG0583	DNA-binding transcription factor activity
DGM85_RS17145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM85_RS17150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGM85_RS17165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGM85_RS17175	COG2197	response regulator
DGM85_RS17180	COG2205	protein histidine kinase activity
DGM85_RS17200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM85_RS17210	COG0697	spore germination
DGM85_RS17235	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DGM85_RS17245	COG3386	PFAM SMP-30 Gluconolaconase
DGM85_RS17265	COG1024	Enoyl-CoA hydratase
DGM85_RS17275	COG0318	PFAM AMP-dependent synthetase and ligase
DGM85_RS17280	COG0583	DNA-binding transcription factor activity
DGM85_RS17285	COG3384	dioxygenase
DGM85_RS17315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_RS17320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_RS17330	COG2096	Adenosyltransferase
DGM85_RS17335	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGM85_RS17345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DGM85_RS17350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM85_RS17355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGM85_RS17360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGM85_RS17365	COG2967	ApaG domain
DGM85_RS17370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGM85_RS17385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGM85_RS17390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGM85_RS17400	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DGM85_RS17410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGM85_RS17420	COG0642	Histidine kinase
DGM85_RS17435	COG4181	ATPase activity
DGM85_RS17445	COG2175	clavaminate synthase activity
DGM85_RS17455	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGM85_RS17460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGM85_RS17480	COG4771	TonB-dependent receptor
DGM85_RS17490	COG0667	Aldo Keto reductase
DGM85_RS17495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGM85_RS17500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM85_RS17510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGM85_RS17515	COG4106	trans-aconitate 2-methyltransferase activity
DGM85_RS17525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGM85_RS17565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGM85_RS17575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGM85_RS17580	COG2226	methyltransferase
DGM85_RS17615	COG0366	Alpha amylase catalytic
DGM85_RS17630	COG0604	alcohol dehydrogenase
DGM85_RS17630	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS17630	COG3321	synthase
DGM85_RS17640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGM85_RS17650	COG0494	nUDIX hydrolase
DGM85_RS17655	COG0653	protein targeting
DGM85_RS17660	COG0739	heme binding
DGM85_RS17670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DGM85_RS17685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGM85_RS17690	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGM85_RS17695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGM85_RS17700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGM85_RS17710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGM85_RS17715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGM85_RS17720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGM85_RS17730	COG3116	cell division
DGM85_RS17770	COG0792	nuclease activity
DGM85_RS17775	COG1988	membrane-bound metal-dependent
DGM85_RS17780	COG0277	FAD linked oxidase domain protein
DGM85_RS17790	COG0745	RESPONSE REGULATOR receiver
DGM85_RS17795	COG2205	protein histidine kinase activity
DGM85_RS17805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGM85_RS17810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGM85_RS17825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGM85_RS17830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGM85_RS17835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DGM85_RS17855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGM85_RS17855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGM85_RS17865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGM85_RS17870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGM85_RS17880	COG0488	(ABC) transporter
DGM85_RS17885	COG0242	peptide deformylase activity
DGM85_RS17910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGM85_RS17915	COG1215	transferase activity, transferring glycosyl groups
DGM85_RS17920	COG1215	transferase activity, transferring glycosyl groups
DGM85_RS17990	COG2188	Transcriptional regulator
DGM85_RS18005	COG1450	Type ii and iii secretion system protein
DGM85_RS18020	COG3166	PFAM Fimbrial assembly family protein
DGM85_RS18025	COG3156	type II secretion system protein K
DGM85_RS18030	COG4795	General secretion pathway protein
DGM85_RS18035	COG2165	general secretion pathway protein
DGM85_RS18040	COG4970	Tfp pilus assembly protein FimT
DGM85_RS18045	COG2165	general secretion pathway protein
DGM85_RS18050	COG1459	type II secretion system
DGM85_RS18055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGM85_RS18060	COG1404	Belongs to the peptidase S8 family
DGM85_RS18065	COG5295	Hep Hag repeat protein
DGM85_RS18070	COG1404	Belongs to the peptidase S8 family
DGM85_RS18075	COG5295	Hep Hag repeat protein
DGM85_RS18080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGM85_RS18080	COG0047	phosphoribosylformylglycinamidine synthase activity
DGM85_RS18085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGM85_RS18095	COG4974	Belongs to the 'phage' integrase family
DGM85_RS18110	COG0795	lipopolysaccharide-transporting ATPase activity
DGM85_RS18120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGM85_RS18135	COG0525	valine-tRNA ligase activity
DGM85_RS18150	COG3039	Transposase
DGM85_RS18155	COG0617	tRNA 3'-terminal CCA addition
DGM85_RS18165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGM85_RS18170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGM85_RS18175	COG1609	Transcriptional regulator
DGM85_RS18185	COG2188	Transcriptional regulator
DGM85_RS18230	COG1459	type II secretion system
DGM85_RS18285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGM85_RS18290	COG4191	Histidine kinase
DGM85_RS18295	COG0784	Response regulator, receiver
DGM85_RS18300	COG4251	negative regulation of phosphorylation
DGM85_RS18305	COG2823	Periplasmic or secreted lipoprotein
DGM85_RS18310	COG0673	inositol 2-dehydrogenase activity
DGM85_RS18315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGM85_RS18350	COG1051	belongs to the nudix hydrolase family
DGM85_RS18350	COG1056	cytidyltransferase-related domain
DGM85_RS18375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGM85_RS18380	COG0321	lipoyl(octanoyl) transferase activity
DGM85_RS18385	COG2921	Belongs to the UPF0250 family
DGM85_RS18395	COG1686	Belongs to the peptidase S11 family
DGM85_RS18400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGM85_RS18405	COG2951	lytic endotransglycosylase activity
DGM85_RS18440	COG0772	Belongs to the SEDS family
DGM85_RS18455	COG1792	Involved in formation and maintenance of cell shape
DGM85_RS18460	COG1077	Cell shape determining protein MreB Mrl
DGM85_RS18465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM85_RS18480	COG3284	Transcriptional regulator
DGM85_RS18525	COG0308	aminopeptidase N
DGM85_RS18530	COG5001	Diguanylate cyclase
DGM85_RS18530	COG3300	MHYT domain
DGM85_RS18535	COG2226	methyltransferase
DGM85_RS18560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DGM85_RS18565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGM85_RS18570	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DGM85_RS18580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGM85_RS18590	COG2832	Protein of unknown function (DUF454)
DGM85_RS18600	COG0436	Aminotransferase
DGM85_RS18610	COG1505	serine-type exopeptidase activity
DGM85_RS18645	COG0181	hydroxymethylbilane synthase activity
DGM85_RS18655	COG3275	phosphorelay sensor kinase activity
DGM85_RS18665	COG2943	transferase activity, transferring hexosyl groups
DGM85_RS18695	COG2205	protein histidine kinase activity
DGM85_RS18695	COG0784	Response regulator, receiver
DGM85_RS18705	COG3447	MASE1 domain protein
DGM85_RS18705	COG5001	Diguanylate cyclase
DGM85_RS18705	COG5002	protein histidine kinase activity
DGM85_RS18750	COG0598	Magnesium transport protein CorA
DGM85_RS18760	COG1113	amino acid transport
DGM85_RS18770	COG5297	Belongs to the glycosyl hydrolase family 6
DGM85_RS18775	COG4305	rare lipoprotein A
DGM85_RS18780	COG0697	spore germination
DGM85_RS18805	COG1959	2 iron, 2 sulfur cluster binding
DGM85_RS18860	COG3328	transposase activity
DGM85_RS18875	COG3039	Transposase
DGM85_RS18925	COG1802	Transcriptional regulator
DGM85_RS18935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGM85_RS18960	COG3052	prosthetic group binding
DGM85_RS18995	COG2353	YceI-like domain
DGM85_RS19000	COG0778	Nitroreductase
DGM85_RS19020	COG3039	Transposase
DGM85_RS19040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGM85_RS19045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGM85_RS19055	COG3386	PFAM SMP-30 Gluconolaconase
DGM85_RS19080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGM85_RS19085	COG3550	peptidyl-serine autophosphorylation
DGM85_RS19100	COG0459	protein refolding
DGM85_RS19120	COG1324	tolerance protein
DGM85_RS19130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGM85_RS19135	COG0511	ligase activity, forming carbon-carbon bonds
DGM85_RS19145	COG0439	Biotin carboxylase
DGM85_RS19160	COG2264	protein methyltransferase activity
DGM85_RS19180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGM85_RS19185	COG4589	Belongs to the CDS family
DGM85_RS19210	COG2453	phosphatase
DGM85_RS19210	COG0671	phosphoesterase, PA-phosphatase related
DGM85_RS19215	COG2267	carboxylic ester hydrolase activity
DGM85_RS19220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGM85_RS19225	COG0138	bifunctional purine biosynthesis protein purh
DGM85_RS19235	COG0151	Belongs to the GarS family
DGM85_RS19245	COG1289	transmembrane transporter activity
DGM85_RS19250	COG2814	Major facilitator Superfamily
DGM85_RS19260	COG2814	Major facilitator Superfamily
DGM85_RS19275	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGM85_RS19290	COG0316	Belongs to the HesB IscA family
DGM85_RS19330	COG1051	belongs to the nudix hydrolase family
DGM85_RS19345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGM85_RS19355	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGM85_RS19365	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DGM85_RS19370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM85_RS19380	COG0134	indole-3-glycerol-phosphate synthase activity
DGM85_RS19385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGM85_RS19415	COG1597	lipid kinase activity
DGM85_RS19435	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DGM85_RS19440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGM85_RS19485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGM85_RS19485	COG2111	Na H antiporter
DGM85_RS19490	COG1006	Multisubunit Na H antiporter MnhC subunit
DGM85_RS19495	COG0651	ATP synthesis coupled electron transport
DGM85_RS19505	COG2212	antiporter activity
DGM85_RS19510	COG1320	monovalent cation:proton antiporter activity
DGM85_RS19525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DGM85_RS19530	COG2852	Protein conserved in bacteria
DGM85_RS19550	COG3104	oligopeptide transport
DGM85_RS19555	COG2801	Transposase and inactivated derivatives
DGM85_RS19560	COG3483	tryptophan 2,3-dioxygenase activity
DGM85_RS19570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGM85_RS19585	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGM85_RS19590	COG0513	Belongs to the DEAD box helicase family
DGM85_RS19600	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS19605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_RS19640	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS19655	COG3039	Transposase
DGM85_RS19665	COG2801	Transposase and inactivated derivatives
DGM85_RS19670	COG1858	cytochrome C peroxidase
DGM85_RS19680	COG0702	epimerase
DGM85_RS19705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM85_RS19710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM85_RS19715	COG0297	glycogen (starch) synthase activity
DGM85_RS19725	COG2354	Protein conserved in bacteria
DGM85_RS19730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGM85_RS19735	COG1368	sulfuric ester hydrolase activity
DGM85_RS19740	COG1511	domain protein
DGM85_RS19740	COG3264	Mechanosensitive ion channel
DGM85_RS19810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGM85_RS19875	COG3039	Transposase
DGM85_RS19895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGM85_RS19900	COG1040	competence protein
DGM85_RS19905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGM85_RS19910	COG0156	8-amino-7-oxononanoate synthase activity
DGM85_RS19920	COG2267	carboxylic ester hydrolase activity
DGM85_RS19950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGM85_RS19960	COG0445	tRNA wobble uridine modification
DGM85_RS19970	COG0657	acetylesterase activity
DGM85_RS19980	COG1414	Transcriptional regulator
DGM85_RS19990	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGM85_RS19995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_RS20005	COG3485	protocatechuate 3,4-dioxygenase
DGM85_RS20010	COG3485	protocatechuate 3,4-dioxygenase
DGM85_RS20025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGM85_RS20050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGM85_RS20110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGM85_RS20125	COG0129	dihydroxy-acid dehydratase activity
DGM85_RS20150	COG1733	regulation of RNA biosynthetic process
DGM85_RS20155	COG0702	epimerase
DGM85_RS20190	COG0583	DNA-binding transcription factor activity
DGM85_RS20195	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGM85_RS20220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_RS20225	COG2205	protein histidine kinase activity
DGM85_RS20230	COG0745	RESPONSE REGULATOR receiver
DGM85_RS20250	COG1902	pentaerythritol trinitrate reductase activity
DGM85_RS20255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGM85_RS20270	COG2814	Major facilitator Superfamily
DGM85_RS20275	COG0583	DNA-binding transcription factor activity
DGM85_RS20290	COG0084	hydrolase, TatD family'
DGM85_RS20310	COG2252	PERMEase
DGM85_RS20345	COG0583	DNA-binding transcription factor activity
DGM85_RS20355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGM85_RS20375	COG2072	flavoprotein involved in K transport
DGM85_RS20385	COG4807	Protein conserved in bacteria
DGM85_RS20390	COG1643	Atp-dependent helicase
DGM85_RS20400	COG1187	pseudouridine synthase activity
DGM85_RS20415	COG2130	NADP-dependent
DGM85_RS20435	COG1764	response to oxidative stress
DGM85_RS20440	COG1846	Transcriptional regulator
DGM85_RS20445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGM85_RS20455	COG0697	spore germination
DGM85_RS20520	COG1960	acyl-CoA dehydrogenase activity
DGM85_RS20525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGM85_RS20530	COG4770	biotin carboxylase activity
DGM85_RS20555	COG3328	transposase activity
DGM85_RS20570	COG3039	Transposase
DGM85_RS20590	COG2224	Isocitrate lyase
DGM85_RS20595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGM85_RS20600	COG0583	DNA-binding transcription factor activity
DGM85_RS20605	COG0475	glutathione-regulated potassium exporter activity
DGM85_RS20640	COG0339	signal peptide processing
DGM85_RS20645	COG1446	asparaginase
DGM85_RS20665	COG0564	pseudouridine synthase activity
DGM85_RS20675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGM85_RS20685	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGM85_RS20700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_RS20705	COG0318	PFAM AMP-dependent synthetase and ligase
DGM85_RS20710	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGM85_RS20715	COG0596	Alpha beta hydrolase
DGM85_RS20720	COG3177	Filamentation induced by cAMP protein fic
DGM85_RS20725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_RS20740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGM85_RS20765	COG2205	protein histidine kinase activity
DGM85_RS20790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGM85_RS20795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DGM85_RS20800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGM85_RS20835	COG0183	Belongs to the thiolase family
DGM85_RS20850	COG2032	superoxide dismutase activity
DGM85_RS20855	COG2032	superoxide dismutase activity
DGM85_RS20860	COG2204	response regulator
DGM85_RS20865	COG3852	Histidine kinase
DGM85_RS20870	COG0004	ammonium transporteR
DGM85_RS20875	COG0347	Belongs to the P(II) protein family
DGM85_RS20880	COG0174	glutamine synthetase
DGM85_RS20885	COG1968	undecaprenyl-diphosphatase activity
DGM85_RS20925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_RS20935	COG2062	phosphohistidine phosphatase, SixA
DGM85_RS20940	COG0489	protein tyrosine kinase activity
DGM85_RS20970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGM85_RS20985	COG1125	glycine betaine transport
DGM85_RS20985	COG0517	IMP dehydrogenase activity
DGM85_RS21000	COG1119	ATPase activity
DGM85_RS21010	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGM85_RS21020	COG1522	sequence-specific DNA binding
DGM85_RS21025	COG3186	Phenylalanine-4-hydroxylase
DGM85_RS21035	COG2755	lipolytic protein G-D-S-L family
DGM85_RS21045	COG3039	Transposase
DGM85_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS21055	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGM85_RS21060	COG1609	Transcriptional regulator
DGM85_RS21065	COG3507	Belongs to the glycosyl hydrolase 43 family
DGM85_RS21080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGM85_RS21090	COG0657	acetylesterase activity
DGM85_RS21090	COG2755	lipolytic protein G-D-S-L family
DGM85_RS21110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM85_RS21115	COG0366	Alpha amylase catalytic
DGM85_RS21120	COG0366	Alpha amylase catalytic
DGM85_RS21135	COG3039	Transposase
DGM85_RS21150	COG3328	transposase activity
DGM85_RS21170	COG0302	gtp cyclohydrolase
DGM85_RS21185	COG1566	PFAM secretion protein HlyD family protein
DGM85_RS21195	COG1289	transmembrane transporter activity
DGM85_RS21200	COG0477	Major facilitator Superfamily
DGM85_RS21210	COG0583	DNA-binding transcription factor activity
DGM85_RS21215	COG4221	oxidoreductase activity
DGM85_RS21225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_RS21280	COG0564	pseudouridine synthase activity
DGM85_RS21310	COG3012	SEC-C Motif Domain Protein
DGM85_RS21380	COG4790	Type iii secretion
DGM85_RS21545	COG3039	Transposase
DGM85_RS21555	COG2801	Transposase and inactivated derivatives
DGM85_RS21565	COG0439	Biotin carboxylase
DGM85_RS21590	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_RS21645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGM85_RS21650	COG1074	ATP-dependent DNA helicase activity
DGM85_RS21655	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGM85_RS21690	COG1127	ABC transporter
DGM85_RS21695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGM85_RS21700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGM85_RS21715	COG2853	Lipoprotein
DGM85_RS21730	COG0386	Belongs to the glutathione peroxidase family
DGM85_RS21740	COG1322	Protein conserved in bacteria
DGM85_RS21750	COG0583	DNA-binding transcription factor activity
DGM85_RS21770	COG0531	amino acid
DGM85_RS21775	COG3537	Alpha-1,2-mannosidase
DGM85_RS21790	COG2199	diguanylate cyclase activity
DGM85_RS21790	COG2203	Gaf domain
DGM85_RS21795	COG3835	regulator
DGM85_RS21800	COG1929	Belongs to the glycerate kinase type-1 family
DGM85_RS21820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGM85_RS21825	COG0861	Integral membrane protein TerC family
DGM85_RS21835	COG0584	glycerophosphoryl diester phosphodiesterase
DGM85_RS21850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DGM85_RS21855	COG0726	polysaccharide deacetylase
DGM85_RS21865	COG0706	membrane insertase activity
DGM85_RS21870	COG0594	ribonuclease P activity
DGM85_RS21990	COG3328	transposase activity
DGM85_RS22030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGM85_RS22035	COG4691	Plasmid stability protein
DGM85_RS22040	COG1487	ribonuclease activity
DGM85_RS22055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGM85_RS22070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGM85_RS22105	COG3846	protein secretion by the type IV secretion system
DGM85_RS22120	COG3451	type IV secretory pathway VirB4
DGM85_RS22135	COG4962	Type ii secretion system protein e
DGM85_RS22250	COG3328	transposase activity
DGM85_RS22345	COG3328	transposase activity
DGM85_RS22360	COG3328	transposase activity
DGM85_RS22435	COG1487	ribonuclease activity
DGM85_RS22440	COG4691	Plasmid stability protein
DGM85_RS22445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGM85_RS22715	COG0840	transmembrane signaling receptor activity
DGM85_RS22770	COG3179	chitinase
DGM85_RS22785	COG3209	COG3209 Rhs family protein
DGM85_RS22840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)