locus-tag	class	description
M0D48_RS00030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M0D48_RS00040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M0D48_RS00050	COG1435	thymidine kinase activity
M0D48_RS00055	COG0210	DNA helicase
M0D48_RS00070	COG3132	Protein of unknown function, DUF480
M0D48_RS00075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M0D48_RS00080	COG0284	orotidine-5'-phosphate decarboxylase activity
M0D48_RS00110	COG2937	Belongs to the GPAT DAPAT family
M0D48_RS00165	COG2211	Major facilitator Superfamily
M0D48_RS00180	COG3693	PFAM glycoside hydrolase, family 10
M0D48_RS00200	COG1904	glucuronate isomerase
M0D48_RS00205	COG3250	beta-galactosidase activity
M0D48_RS00220	COG3386	PFAM SMP-30 Gluconolaconase
M0D48_RS00245	COG0246	Mannitol dehydrogenase
M0D48_RS00250	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_RS00260	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_RS00270	COG3661	Belongs to the glycosyl hydrolase 67 family
M0D48_RS00290	COG2974	May be involved in recombination
M0D48_RS00305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M0D48_RS00315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D48_RS00320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D48_RS00325	COG0805	protein transport
M0D48_RS00335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M0D48_RS00335	COG0519	Catalyzes the synthesis of GMP from XMP
M0D48_RS00345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D48_RS00350	COG0752	glycyl-tRNA synthetase alpha subunit
M0D48_RS00360	COG0457	Tetratricopeptide repeat
M0D48_RS00365	COG4771	TonB-dependent receptor
M0D48_RS00370	COG0729	surface antigen
M0D48_RS00375	COG2911	Protein conserved in bacteria
M0D48_RS00395	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_RS00400	COG3265	gluconokinase activity
M0D48_RS00405	COG2211	Major facilitator Superfamily
M0D48_RS00410	COG3459	Glycosyltransferase 36 associated
M0D48_RS00420	COG2205	protein histidine kinase activity
M0D48_RS00440	COG1414	Transcriptional regulator
M0D48_RS00445	COG0738	Major facilitator superfamily
M0D48_RS00450	COG3254	rhamnose metabolic process
M0D48_RS00455	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_RS00460	COG0179	Fumarylacetoacetate (FAA) hydrolase
M0D48_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS00515	COG3162	membrane
M0D48_RS00520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M0D48_RS00525	COG1940	carbohydrate kinase activity
M0D48_RS00545	COG2091	lysine biosynthetic process via aminoadipic acid
M0D48_RS00555	COG3540	Alkaline phosphatase
M0D48_RS00560	COG0357	Ribosomal RNA small subunit methyltransferase G
M0D48_RS00580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS00605	COG2159	amidohydrolase
M0D48_RS00615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D48_RS00620	COG0583	DNA-binding transcription factor activity
M0D48_RS00625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_RS00640	COG0210	DNA helicase
M0D48_RS00730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D48_RS00730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D48_RS00740	COG0408	coproporphyrinogen oxidase activity
M0D48_RS00755	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_RS00755	COG1506	peptidase
M0D48_RS00755	COG4946	Tricorn protease homolog
M0D48_RS00770	COG0644	oxidoreductase
M0D48_RS00775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D48_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS00835	COG0463	Glycosyl transferase, family 2
M0D48_RS00845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M0D48_RS00850	COG3100	YcgL domain-containing protein
M0D48_RS00865	COG3387	PFAM Glycoside hydrolase 15-related
M0D48_RS00870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D48_RS00905	COG2239	Acts as a magnesium transporter
M0D48_RS00915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M0D48_RS00915	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D48_RS00915	COG1042	CoA-binding domain protein
M0D48_RS00925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D48_RS00930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D48_RS00960	COG1607	acyl-coa hydrolase
M0D48_RS00975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M0D48_RS00980	COG0842	Transport permease protein
M0D48_RS00985	COG1131	(ABC) transporter
M0D48_RS00990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D48_RS01010	COG1476	TRANSCRIPTIONal
M0D48_RS01020	COG4555	ABC transporter
M0D48_RS01055	COG0625	glutathione transferase activity
M0D48_RS01150	COG1199	ATP-dependent helicase activity
M0D48_RS01185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D48_RS01230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M0D48_RS01245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M0D48_RS01285	COG3237	CsbD-like
M0D48_RS01290	COG0180	Tryptophanyl-tRNA synthetase
M0D48_RS01315	COG0697	spore germination
M0D48_RS01340	COG1136	(ABC) transporter
M0D48_RS01345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS01350	COG4585	Histidine kinase
M0D48_RS01355	COG2197	response regulator
M0D48_RS01370	COG0753	catalase activity
M0D48_RS01375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D48_RS01380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D48_RS01385	COG0628	permease
M0D48_RS01405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D48_RS01415	COG1090	epimerase
M0D48_RS01450	COG1690	Belongs to the RtcB family
M0D48_RS01480	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M0D48_RS01495	COG0606	chelatase, subunit chli
M0D48_RS01510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D48_RS01510	COG3291	Pkd domain containing protein
M0D48_RS01530	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M0D48_RS01535	COG1166	arginine decarboxylase activity
M0D48_RS01545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D48_RS01555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M0D48_RS01555	COG2755	lipolytic protein G-D-S-L family
M0D48_RS01560	COG4221	oxidoreductase activity
M0D48_RS01575	COG0018	arginyl-trna synthetase
M0D48_RS01580	COG2003	Belongs to the UPF0758 family
M0D48_RS01585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M0D48_RS01610	COG0463	Glycosyl transferase, family 2
M0D48_RS01625	COG1475	DNA binding
M0D48_RS01630	COG1192	Involved in chromosome partitioning
M0D48_RS01645	COG0708	Exodeoxyribonuclease III
M0D48_RS01650	COG2223	nitrite transmembrane transporter activity
M0D48_RS01665	COG0739	heme binding
M0D48_RS01710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M0D48_RS01725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M0D48_RS01775	COG0358	DNA primase activity
M0D48_RS01780	COG1295	ribonuclease BN
M0D48_RS01790	COG1610	YqeY-like protein
M0D48_RS01800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M0D48_RS01805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M0D48_RS01815	COG2133	pyrroloquinoline quinone binding
M0D48_RS01820	COG4682	membrane
M0D48_RS01835	COG0531	amino acid
M0D48_RS01845	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_RS01855	COG3023	N-Acetylmuramoyl-L-alanine amidase
M0D48_RS01860	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M0D48_RS01895	COG5383	Protein conserved in bacteria
M0D48_RS01920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_RS01925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS01930	COG1473	amidohydrolase
M0D48_RS01935	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D48_RS01935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D48_RS01940	COG1652	LysM domain
M0D48_RS01965	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M0D48_RS01975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M0D48_RS01980	COG3118	belongs to the thioredoxin family
M0D48_RS01990	COG2884	Cell division ATP-binding protein ftsE
M0D48_RS01995	COG2177	Part of the ABC transporter FtsEX involved in
M0D48_RS02000	COG2201	protein-glutamate methylesterase activity
M0D48_RS02005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M0D48_RS02010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D48_RS02015	COG2860	membrane
M0D48_RS02020	COG1252	NADH dehydrogenase
M0D48_RS02035	COG0625	glutathione transferase activity
M0D48_RS02040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M0D48_RS02060	COG0534	Mate efflux family protein
M0D48_RS02065	COG0616	signal peptide processing
M0D48_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS02090	COG0009	L-threonylcarbamoyladenylate synthase
M0D48_RS02095	COG1754	DNA topoisomerase type I activity
M0D48_RS02095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M0D48_RS02115	COG0758	DNA mediated transformation
M0D48_RS02120	COG1652	LysM domain
M0D48_RS02125	COG0242	peptide deformylase activity
M0D48_RS02130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M0D48_RS02135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D48_RS02135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M0D48_RS02180	COG1560	Kdo2-lipid A biosynthetic process
M0D48_RS02185	COG1490	D-aminoacyl-tRNA deacylase activity
M0D48_RS02190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D48_RS02205	COG0582	viral genome integration into host DNA
M0D48_RS02390	COG1999	signal sequence binding
M0D48_RS02405	COG0024	Methionine aminopeptidase
M0D48_RS02415	COG0038	chloride channel
M0D48_RS02450	COG0251	oxidation-reduction process
M0D48_RS02465	COG1131	(ABC) transporter
M0D48_RS02525	COG1063	alcohol dehydrogenase
M0D48_RS02535	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS02550	COG1294	oxidase, subunit
M0D48_RS02555	COG1271	oxidase subunit
M0D48_RS02570	COG3546	catalase activity
M0D48_RS02575	COG3685	Protein conserved in bacteria
M0D48_RS02590	COG2972	Histidine kinase
M0D48_RS02605	COG0531	amino acid
M0D48_RS02620	COG3590	peptidase
M0D48_RS02630	COG0667	Aldo Keto reductase
M0D48_RS02640	COG0583	DNA-binding transcription factor activity
M0D48_RS02650	COG3384	dioxygenase
M0D48_RS02660	COG1573	uracil-dna glycosylase
M0D48_RS02665	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M0D48_RS02675	COG0025	NhaP-type Na H and K H
M0D48_RS02680	COG1131	(ABC) transporter
M0D48_RS02685	COG0842	Transport permease protein
M0D48_RS02720	COG3227	Zinc metalloprotease (Elastase)
M0D48_RS02740	COG0745	RESPONSE REGULATOR receiver
M0D48_RS02785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_RS02790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M0D48_RS02810	COG2205	protein histidine kinase activity
M0D48_RS02810	COG2202	Pas domain
M0D48_RS02830	COG2813	Specifically methylates the guanine in position
M0D48_RS02835	COG1187	pseudouridine synthase activity
M0D48_RS02840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D48_RS02860	COG3850	Histidine kinase
M0D48_RS02860	COG2205	protein histidine kinase activity
M0D48_RS02860	COG3437	response regulator, receiver
M0D48_RS02860	COG4999	Histidine kinase
M0D48_RS02875	COG0697	spore germination
M0D48_RS02880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M0D48_RS02885	COG2011	ABC-type metal ion transport system permease component
M0D48_RS02925	COG0508	dehydrogenase complex catalyzes the overall conversion of
M0D48_RS02935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D48_RS02960	COG0356	it plays a direct role in the translocation of protons across the membrane
M0D48_RS02970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M0D48_RS02975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M0D48_RS02980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M0D48_RS02985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M0D48_RS03010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M0D48_RS03030	COG1136	(ABC) transporter
M0D48_RS03030	COG0577	efflux transmembrane transporter activity
M0D48_RS03035	COG0577	efflux transmembrane transporter activity
M0D48_RS03035	COG1136	(ABC) transporter
M0D48_RS03040	COG1136	(ABC) transporter
M0D48_RS03040	COG0577	efflux transmembrane transporter activity
M0D48_RS03045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS03050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D48_RS03115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M0D48_RS03125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D48_RS03140	COG1956	GAF domain-containing protein
M0D48_RS03145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M0D48_RS03155	COG0720	synthase
M0D48_RS03160	COG0513	Belongs to the DEAD box helicase family
M0D48_RS03170	COG0625	glutathione transferase activity
M0D48_RS03200	COG0626	cystathionine gamma-synthase activity
M0D48_RS03215	COG0110	maltose O-acetyltransferase activity
M0D48_RS03220	COG0438	transferase activity, transferring glycosyl groups
M0D48_RS03220	COG1216	Glycosyl transferase, family 2
M0D48_RS03225	COG3754	Rhamnan synthesis protein F
M0D48_RS03235	COG2226	methyltransferase
M0D48_RS03255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D48_RS03265	COG0300	oxidoreductase activity
M0D48_RS03270	COG0277	FAD linked oxidase domain protein
M0D48_RS03275	COG0546	phosphoglycolate phosphatase activity
M0D48_RS03275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D48_RS03290	COG2086	electron transfer activity
M0D48_RS03315	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M0D48_RS03315	COG0662	Cupin 2, conserved barrel domain protein
M0D48_RS03320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D48_RS03355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M0D48_RS03355	COG3218	ABC-type transport auxiliary lipoprotein component
M0D48_RS03360	COG1127	ABC transporter
M0D48_RS03365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D48_RS03380	COG0442	prolyl-tRNA aminoacylation
M0D48_RS03390	COG1183	phosphatidylcholine synthase activity
M0D48_RS03410	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D48_RS03415	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_RS03420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M0D48_RS03430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D48_RS03445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M0D48_RS03455	COG2205	protein histidine kinase activity
M0D48_RS03480	COG3791	Glutathione-dependent formaldehyde-activating
M0D48_RS03505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D48_RS03510	COG0697	spore germination
M0D48_RS03520	COG1307	EDD domain protein, DegV family
M0D48_RS03555	COG0402	S-adenosylhomocysteine deaminase activity
M0D48_RS03560	COG3964	amidohydrolase
M0D48_RS03575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D48_RS03595	COG0436	Aminotransferase
M0D48_RS03600	COG1162	GTPase activity
M0D48_RS03630	COG2211	Major facilitator Superfamily
M0D48_RS03635	COG1609	Transcriptional regulator
M0D48_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS03645	COG2851	Citrate transporter
M0D48_RS03660	COG0642	Histidine kinase
M0D48_RS03670	COG2197	response regulator
M0D48_RS03690	COG0667	Aldo Keto reductase
M0D48_RS03695	COG0583	DNA-binding transcription factor activity
M0D48_RS03710	COG4191	Histidine kinase
M0D48_RS03725	COG1301	dicarboxylic acid transport
M0D48_RS03730	COG0280	phosphate acetyltransferase
M0D48_RS03730	COG0281	malic enzyme
M0D48_RS03900	COG1560	Kdo2-lipid A biosynthetic process
M0D48_RS03905	COG1519	Transferase
M0D48_RS03910	COG1538	Outer membrane efflux protein
M0D48_RS03915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D48_RS03935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M0D48_RS03940	COG0066	3-isopropylmalate dehydratase activity
M0D48_RS03950	COG0473	3-isopropylmalate dehydrogenase activity
M0D48_RS03955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M0D48_RS03975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M0D48_RS03980	COG0405	Gamma-glutamyltransferase
M0D48_RS03985	COG0840	transmembrane signaling receptor activity
M0D48_RS03990	COG1506	peptidase
M0D48_RS03990	COG4946	Tricorn protease homolog
M0D48_RS03990	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_RS03995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M0D48_RS04000	COG3710	Transcriptional regulator
M0D48_RS04020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M0D48_RS04030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M0D48_RS04090	COG0563	adenylate kinase activity
M0D48_RS04095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D48_RS04105	COG3781	membrane
M0D48_RS04110	COG0671	phosphoesterase, PA-phosphatase related
M0D48_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS04135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D48_RS04165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D48_RS04170	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M0D48_RS04185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M0D48_RS04200	COG0352	thiamine-phosphate diphosphorylase activity
M0D48_RS04205	COG1773	rubredoxin
M0D48_RS04210	COG2912	Transglutaminase-like superfamily
M0D48_RS04230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M0D48_RS04255	COG0006	proline dipeptidase activity
M0D48_RS04265	COG0006	proline dipeptidase activity
M0D48_RS04280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M0D48_RS04285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M0D48_RS04295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M0D48_RS04300	COG1561	YicC-like family, N-terminal region
M0D48_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS04335	COG1175	transmembrane transport
M0D48_RS04340	COG3659	wide pore channel activity
M0D48_RS04350	COG2390	Transcriptional regulator
M0D48_RS04355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D48_RS04360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D48_RS04365	COG0583	DNA-binding transcription factor activity
M0D48_RS04380	COG2271	Major facilitator Superfamily
M0D48_RS04395	COG2721	sulfolactate sulfo-lyase activity
M0D48_RS04405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M0D48_RS04435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M0D48_RS04465	COG0714	Associated with various cellular activities
M0D48_RS04485	COG2304	oxidoreductase activity
M0D48_RS04495	COG1301	dicarboxylic acid transport
M0D48_RS04505	COG4773	Receptor
M0D48_RS04510	COG0583	DNA-binding transcription factor activity
M0D48_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS04520	COG0739	heme binding
M0D48_RS04525	COG1376	ErfK ybiS ycfS ynhG family protein
M0D48_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS04575	COG0642	Histidine kinase
M0D48_RS04595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M0D48_RS04600	COG4149	molybdate abc transporter
M0D48_RS04605	COG0725	ABC transporter, periplasmic molybdate-binding protein
M0D48_RS04610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M0D48_RS04610	COG3453	Protein conserved in bacteria
M0D48_RS04620	COG3047	cAMP biosynthetic process
M0D48_RS04630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M0D48_RS04660	COG0469	pyruvate kinase activity
M0D48_RS04665	COG3588	fructose-bisphosphate aldolase
M0D48_RS04670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M0D48_RS04695	COG0583	DNA-binding transcription factor activity
M0D48_RS04705	COG0784	Response regulator, receiver
M0D48_RS04705	COG2205	protein histidine kinase activity
M0D48_RS04705	COG2198	Histidine kinase
M0D48_RS04725	COG0175	sulfate reduction
M0D48_RS04730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D48_RS04735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D48_RS04740	COG0175	sulfate reduction
M0D48_RS04745	COG2895	sulfate adenylyltransferase (ATP) activity
M0D48_RS04745	COG0529	Catalyzes the synthesis of activated sulfate
M0D48_RS04755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_RS04770	COG0308	aminopeptidase N
M0D48_RS04780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D48_RS04790	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_RS04795	COG3250	beta-galactosidase activity
M0D48_RS04815	COG1609	Transcriptional regulator
M0D48_RS04825	COG1970	mechanosensitive ion channel activity
M0D48_RS04845	COG0471	metal ion transport
M0D48_RS04845	COG3273	potassium ion transport
M0D48_RS04855	COG2022	thiamine diphosphate biosynthetic process
M0D48_RS04910	COG0745	RESPONSE REGULATOR receiver
M0D48_RS04970	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M0D48_RS04980	COG4969	Belongs to the N-Me-Phe pilin family
M0D48_RS04985	COG2194	sulfuric ester hydrolase activity
M0D48_RS05020	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D48_RS05035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M0D48_RS05035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D48_RS05040	COG0537	adenosine 5'-monophosphoramidase activity
M0D48_RS05045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_RS05050	COG0564	pseudouridine synthase activity
M0D48_RS05065	COG3011	Protein conserved in bacteria
M0D48_RS05070	COG0840	transmembrane signaling receptor activity
M0D48_RS05085	COG3387	PFAM Glycoside hydrolase 15-related
M0D48_RS05090	COG1877	trehalose-phosphatase activity
M0D48_RS05140	COG0542	response to heat
M0D48_RS05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS05175	COG4206	TonB-dependent receptor
M0D48_RS05200	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D48_RS05210	COG1492	cobalamin metabolic process
M0D48_RS05220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M0D48_RS05250	COG0019	diaminopimelate decarboxylase activity
M0D48_RS05265	COG4264	IucA IucC family
M0D48_RS05275	COG4772	TonB-dependent receptor
M0D48_RS05300	COG4651	solute:proton antiporter activity
M0D48_RS05300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D48_RS05335	COG0488	(ABC) transporter
M0D48_RS05375	COG0477	Major facilitator Superfamily
M0D48_RS05390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M0D48_RS05410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M0D48_RS05420	COG3158	transport of potassium into the cell
M0D48_RS05430	COG2255	four-way junction helicase activity
M0D48_RS05435	COG0824	Thioesterase
M0D48_RS05455	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_RS05460	COG2885	chlorophyll binding
M0D48_RS05470	COG0602	queuosine metabolic process
M0D48_RS05480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M0D48_RS05510	COG0840	transmembrane signaling receptor activity
M0D48_RS05520	COG1187	pseudouridine synthase activity
M0D48_RS05540	COG0514	ATP-dependent DNA helicase (RecQ)
M0D48_RS05545	COG0783	Belongs to the Dps family
M0D48_RS05550	COG1643	Atp-dependent helicase
M0D48_RS05590	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M0D48_RS05605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D48_RS05615	COG1215	transferase activity, transferring glycosyl groups
M0D48_RS05620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D48_RS05630	COG1199	ATP-dependent helicase activity
M0D48_RS05640	COG1397	ADP-ribosylglycohydrolase
M0D48_RS05650	COG0189	ligase activity
M0D48_RS05665	COG0835	chemotaxis
M0D48_RS05670	COG0840	transmembrane signaling receptor activity
M0D48_RS05675	COG2198	Histidine kinase
M0D48_RS05675	COG0643	Histidine kinase
M0D48_RS05675	COG0784	Response regulator, receiver
M0D48_RS05700	COG1595	DNA-templated transcription, initiation
M0D48_RS05705	COG2304	oxidoreductase activity
M0D48_RS05710	COG1446	asparaginase
M0D48_RS05715	COG3142	Participates in the control of copper homeostasis
M0D48_RS05750	COG3537	Alpha-1,2-mannosidase
M0D48_RS05760	COG1486	melibiose metabolic process
M0D48_RS05770	COG0531	amino acid
M0D48_RS05785	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_RS05795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D48_RS05805	COG1388	LysM domain
M0D48_RS05805	COG3858	chitin binding
M0D48_RS05820	COG0837	glucose binding
M0D48_RS05825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M0D48_RS05835	COG0494	nUDIX hydrolase
M0D48_RS05845	COG3956	TIGRFAM MazG family protein
M0D48_RS05850	COG1742	UPF0060 membrane protein
M0D48_RS05855	COG0330	HflC and HflK could
M0D48_RS05865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M0D48_RS05870	COG0509	glycine decarboxylation via glycine cleavage system
M0D48_RS05895	COG1960	acyl-CoA dehydrogenase activity
M0D48_RS05905	COG1309	transcriptional regulator
M0D48_RS05910	COG4771	TonB-dependent receptor
M0D48_RS05920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M0D48_RS05925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D48_RS05930	COG0463	Glycosyl transferase, family 2
M0D48_RS05935	COG0516	GMP reductase activity
M0D48_RS05935	COG0517	IMP dehydrogenase activity
M0D48_RS05940	COG2982	Protein involved in outer membrane biogenesis
M0D48_RS05945	COG1272	protein, Hemolysin III
M0D48_RS05950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M0D48_RS05955	COG0739	heme binding
M0D48_RS05960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D48_RS05965	COG0626	cystathionine gamma-synthase activity
M0D48_RS05970	COG0460	homoserine dehydrogenase
M0D48_RS05970	COG0527	aspartate kinase activity
M0D48_RS05980	COG1760	l-serine dehydratase
M0D48_RS06000	COG2353	YceI-like domain
M0D48_RS06010	COG0784	Response regulator, receiver
M0D48_RS06010	COG5002	protein histidine kinase activity
M0D48_RS06015	COG2205	protein histidine kinase activity
M0D48_RS06015	COG0784	Response regulator, receiver
M0D48_RS06025	COG2814	Major facilitator Superfamily
M0D48_RS06030	COG2204	response regulator
M0D48_RS06100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M0D48_RS06115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M0D48_RS06130	COG1842	Phage shock protein A
M0D48_RS06155	COG0754	glutathionylspermidine amidase activity
M0D48_RS06160	COG2814	Major facilitator Superfamily
M0D48_RS06220	COG0531	amino acid
M0D48_RS06240	COG1113	amino acid transport
M0D48_RS06250	COG1271	oxidase subunit
M0D48_RS06255	COG1294	oxidase, subunit
M0D48_RS06265	COG2239	Acts as a magnesium transporter
M0D48_RS06270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D48_RS06275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D48_RS06285	COG1660	Displays ATPase and GTPase activities
M0D48_RS06295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D48_RS06310	COG1137	ATPase activity
M0D48_RS06325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M0D48_RS06335	COG0271	Belongs to the BolA IbaG family
M0D48_RS06340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M0D48_RS06360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M0D48_RS06370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M0D48_RS06380	COG0628	permease
M0D48_RS06395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M0D48_RS06400	COG3178	'Phosphotransferase
M0D48_RS06410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D48_RS06415	COG1555	photosystem II stabilization
M0D48_RS06430	COG1477	protein flavinylation
M0D48_RS06455	COG3128	pkhd-type hydroxylase
M0D48_RS06460	COG4774	siderophore transport
M0D48_RS06465	COG2146	nitrite reductase [NAD(P)H] activity
M0D48_RS06475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M0D48_RS06480	COG0719	Fe-S assembly protein
M0D48_RS06485	COG0396	ATPase activity
M0D48_RS06490	COG0719	Fe-S assembly protein
M0D48_RS06495	COG1959	2 iron, 2 sulfur cluster binding
M0D48_RS06505	COG0693	protein deglycase activity
M0D48_RS06525	COG4942	peptidase
M0D48_RS06545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M0D48_RS06570	COG0519	Catalyzes the synthesis of GMP from XMP
M0D48_RS06575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M0D48_RS06580	COG1678	Uncharacterized ACR, COG1678
M0D48_RS06585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M0D48_RS06590	COG0540	Belongs to the ATCase OTCase family
M0D48_RS06595	COG1764	response to oxidative stress
M0D48_RS06605	COG0384	phenazine biosynthesis protein PhzF
M0D48_RS06615	COG0527	aspartate kinase activity
M0D48_RS06640	COG0142	geranyltranstransferase activity
M0D48_RS06645	COG0629	single-stranded DNA binding
M0D48_RS06690	COG0673	inositol 2-dehydrogenase activity
M0D48_RS06695	COG2211	Major facilitator Superfamily
M0D48_RS06705	COG1609	Transcriptional regulator
M0D48_RS06710	COG2203	Gaf domain
M0D48_RS06710	COG4251	negative regulation of phosphorylation
M0D48_RS06710	COG5001	Diguanylate cyclase
M0D48_RS06710	COG3706	GGDEF domain
M0D48_RS06720	COG2080	2 iron, 2 sulfur cluster binding
M0D48_RS06725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D48_RS06730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D48_RS06735	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M0D48_RS06770	COG2879	small protein
M0D48_RS06775	COG1966	Carbon starvation protein
M0D48_RS06780	COG1741	Belongs to the pirin family
M0D48_RS06795	COG1741	Belongs to the pirin family
M0D48_RS06800	COG1515	deoxyribonuclease V activity
M0D48_RS06805	COG0588	phosphoglycerate mutase activity
M0D48_RS06815	COG3590	peptidase
M0D48_RS06820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_RS06830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D48_RS06835	COG2202	Pas domain
M0D48_RS06835	COG2199	diguanylate cyclase activity
M0D48_RS06835	COG2200	EAL domain
M0D48_RS06840	COG0835	chemotaxis
M0D48_RS06845	COG0840	transmembrane signaling receptor activity
M0D48_RS06850	COG0643	Histidine kinase
M0D48_RS06850	COG2198	Histidine kinase
M0D48_RS06860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M0D48_RS06870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M0D48_RS06875	COG0745	RESPONSE REGULATOR receiver
M0D48_RS06885	COG2205	protein histidine kinase activity
M0D48_RS06895	COG4452	Inner membrane protein CreD
M0D48_RS06920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D48_RS06925	COG0735	belongs to the Fur family
M0D48_RS06940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_RS06950	COG1309	transcriptional regulator
M0D48_RS06960	COG2207	Transcriptional regulator
M0D48_RS06975	COG0583	DNA-binding transcription factor activity
M0D48_RS06980	COG2814	Major facilitator Superfamily
M0D48_RS06985	COG0667	Aldo Keto reductase
M0D48_RS07085	COG5002	protein histidine kinase activity
M0D48_RS07085	COG5001	Diguanylate cyclase
M0D48_RS07090	COG1187	pseudouridine synthase activity
M0D48_RS07115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D48_RS07125	COG0475	glutathione-regulated potassium exporter activity
M0D48_RS07130	COG5000	phosphorelay sensor kinase activity
M0D48_RS07130	COG5002	protein histidine kinase activity
M0D48_RS07135	COG0745	RESPONSE REGULATOR receiver
M0D48_RS07145	COG3713	MltA-interacting MipA family protein
M0D48_RS07165	COG1132	(ABC) transporter
M0D48_RS07250	COG3118	belongs to the thioredoxin family
M0D48_RS07260	COG0495	leucyl-tRNA aminoacylation
M0D48_RS07275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M0D48_RS07290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M0D48_RS07310	COG2968	Membrane
M0D48_RS07325	COG3164	Protein of unknown function
M0D48_RS07335	COG0312	modulator of DNA gyrase
M0D48_RS07340	COG3028	Belongs to the UPF0307 family
M0D48_RS07345	COG0312	modulator of DNA gyrase
M0D48_RS07355	COG4104	PAAR repeat-containing protein
M0D48_RS07360	COG0142	geranyltranstransferase activity
M0D48_RS07365	COG1722	exodeoxyribonuclease VII activity
M0D48_RS07370	COG0037	tRNA processing
M0D48_RS07375	COG1785	Belongs to the alkaline phosphatase family
M0D48_RS07380	COG1301	dicarboxylic acid transport
M0D48_RS07385	COG2226	methyltransferase
M0D48_RS07400	COG0791	NLP P60 protein
M0D48_RS07405	COG0791	NLP P60 protein
M0D48_RS07410	COG1047	Peptidyl-prolyl cis-trans
M0D48_RS07415	COG2311	Membrane
M0D48_RS07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_RS07425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D48_RS07445	COG3590	peptidase
M0D48_RS07450	COG3590	peptidase
M0D48_RS07470	COG0489	protein tyrosine kinase activity
M0D48_RS07475	COG0717	Belongs to the dCTP deaminase family
M0D48_RS07505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M0D48_RS07510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D48_RS07525	COG0494	nUDIX hydrolase
M0D48_RS07535	COG0433	COG0433 Predicted ATPase
M0D48_RS07545	COG0688	phosphatidylethanolamine metabolic process
M0D48_RS07555	COG2890	protein-(glutamine-N5) methyltransferase activity
M0D48_RS07560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M0D48_RS07565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M0D48_RS07570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M0D48_RS07590	COG0101	tRNA pseudouridine synthase activity
M0D48_RS07595	COG0135	phosphoribosylanthranilate isomerase activity
M0D48_RS07610	COG0133	tryptophan synthase activity
M0D48_RS07625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M0D48_RS07630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D48_RS07665	COG0149	triose-phosphate isomerase activity
M0D48_RS07680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D48_RS07690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D48_RS07695	COG0649	NAD binding
M0D48_RS07700	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M0D48_RS07710	COG1034	ATP synthesis coupled electron transport
M0D48_RS07715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M0D48_RS07725	COG0839	Belongs to the complex I subunit 6 family
M0D48_RS07745	COG1007	ATP synthesis coupled electron transport
M0D48_RS07755	COG0779	Required for maturation of 30S ribosomal subunits
M0D48_RS07760	COG0195	Participates in both transcription termination and antitermination
M0D48_RS07770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M0D48_RS07780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M0D48_RS07785	COG1185	polyribonucleotide nucleotidyltransferase activity
M0D48_RS07820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D48_RS07830	COG2095	MarC family integral membrane protein
M0D48_RS07840	COG1611	Belongs to the LOG family
M0D48_RS07885	COG0556	nucleotide-excision repair
M0D48_RS07900	COG3505	Type IV secretory pathway VirD4
M0D48_RS07920	COG2948	multi-organism process
M0D48_RS07940	COG3702	type iv secretory pathway
M0D48_RS07950	COG0366	Alpha amylase catalytic
M0D48_RS07985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M0D48_RS07990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M0D48_RS08005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M0D48_RS08010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D48_RS08010	COG0072	phenylalanine-tRNA ligase activity
M0D48_RS08065	COG0438	transferase activity, transferring glycosyl groups
M0D48_RS08070	COG0438	transferase activity, transferring glycosyl groups
M0D48_RS08080	COG0438	transferase activity, transferring glycosyl groups
M0D48_RS08105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_RS08115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D48_RS08135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M0D48_RS08145	COG1960	acyl-CoA dehydrogenase activity
M0D48_RS08155	COG3040	lipid binding
M0D48_RS08175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D48_RS08185	COG0784	Response regulator, receiver
M0D48_RS08185	COG4191	Histidine kinase
M0D48_RS08195	COG1194	a g-specific adenine glycosylase
M0D48_RS08200	COG0552	protein localization to endoplasmic reticulum
M0D48_RS08210	COG3938	Belongs to the proline racemase family
M0D48_RS08215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_RS08230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D48_RS08240	COG0006	proline dipeptidase activity
M0D48_RS08255	COG0531	amino acid
M0D48_RS08300	COG1506	peptidase
M0D48_RS08300	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_RS08320	COG0326	Molecular chaperone. Has ATPase activity
M0D48_RS08325	COG0742	ribosomal rna small subunit methyltransferase
M0D48_RS08330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M0D48_RS08340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M0D48_RS08345	COG0405	Gamma-glutamyltransferase
M0D48_RS08355	COG3291	Pkd domain containing protein
M0D48_RS08360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M0D48_RS08385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D48_RS08400	COG0343	queuine tRNA-ribosyltransferase activity
M0D48_RS08405	COG1862	Preprotein translocase
M0D48_RS08415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M0D48_RS08450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D48_RS08450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D48_RS08455	COG1105	Belongs to the carbohydrate kinase PfkB family
M0D48_RS08460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D48_RS08460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D48_RS08470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_RS08475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS08485	COG2902	Dehydrogenase
M0D48_RS08530	COG0477	Major facilitator Superfamily
M0D48_RS08540	COG2205	protein histidine kinase activity
M0D48_RS08540	COG5002	protein histidine kinase activity
M0D48_RS08540	COG0784	Response regulator, receiver
M0D48_RS08545	COG2733	membrane
M0D48_RS08555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M0D48_RS08565	COG2223	nitrite transmembrane transporter activity
M0D48_RS08570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M0D48_RS08575	COG0243	molybdopterin cofactor binding
M0D48_RS08585	COG0477	Major facilitator Superfamily
M0D48_RS08595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_RS08600	COG0174	glutamine synthetase
M0D48_RS08605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M0D48_RS08620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M0D48_RS08640	COG3842	ATPase activity
M0D48_RS08645	COG1176	ABC-type spermidine putrescine transport system, permease component I
M0D48_RS08650	COG1177	transmembrane transport
M0D48_RS08660	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_RS08675	COG4535	Mg2 and Co2 transporter CorC
M0D48_RS08685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M0D48_RS08695	COG1702	phosphate starvation-inducible protein PhoH
M0D48_RS08715	COG0741	lytic transglycosylase activity
M0D48_RS08720	COG0723	plastoquinol--plastocyanin reductase activity
M0D48_RS08725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M0D48_RS08730	COG2857	Cytochrome c1
M0D48_RS08735	COG0625	glutathione transferase activity
M0D48_RS08740	COG2969	positive regulation of protein catabolic process
M0D48_RS08765	COG1201	RNA secondary structure unwinding
M0D48_RS08775	COG0835	chemotaxis
M0D48_RS08820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D48_RS08830	COG1570	exodeoxyribonuclease VII activity
M0D48_RS08840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M0D48_RS08840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M0D48_RS08845	COG0802	atpase or kinase
M0D48_RS08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D48_RS08855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M0D48_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS08880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D48_RS08885	COG0501	Belongs to the peptidase M48B family
M0D48_RS08900	COG4681	YaeQ
M0D48_RS08905	COG1671	Belongs to the UPF0178 family
M0D48_RS08915	COG0625	glutathione transferase activity
M0D48_RS08925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M0D48_RS08930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M0D48_RS08935	COG0513	Belongs to the DEAD box helicase family
M0D48_RS08940	COG0488	(ABC) transporter
M0D48_RS08955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M0D48_RS08960	COG0483	inositol monophosphate 1-phosphatase activity
M0D48_RS08975	COG5001	Diguanylate cyclase
M0D48_RS08975	COG3300	MHYT domain
M0D48_RS08980	COG1509	lysine 2,3-aminomutase activity
M0D48_RS09000	COG0402	S-adenosylhomocysteine deaminase activity
M0D48_RS09005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D48_RS09025	COG4677	pectinesterase activity
M0D48_RS09045	COG4302	ethanolamine ammonia-lyase activity
M0D48_RS09065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M0D48_RS09095	COG2166	iron-sulfur cluster assembly
M0D48_RS09100	COG0215	cysteine-tRNA ligase activity
M0D48_RS09110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M0D48_RS09115	COG0137	argininosuccinate synthase activity
M0D48_RS09120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D48_RS09125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M0D48_RS09140	COG0165	Argininosuccinate lyase
M0D48_RS09205	COG1294	oxidase, subunit
M0D48_RS09215	COG4988	ABC transporter
M0D48_RS09220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M0D48_RS09230	COG1278	Cold shock
M0D48_RS09235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D48_RS09260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D48_RS09280	COG4133	protoheme IX ABC transporter activity
M0D48_RS09285	COG0436	Aminotransferase
M0D48_RS09305	COG1187	pseudouridine synthase activity
M0D48_RS09310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M0D48_RS09315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M0D48_RS09320	COG2350	Protein conserved in bacteria
M0D48_RS09350	COG1175	transmembrane transport
M0D48_RS09355	COG0395	ABC-type sugar transport system, permease component
M0D48_RS09380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D48_RS09385	COG2957	Belongs to the agmatine deiminase family
M0D48_RS09400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M0D48_RS09405	COG0539	negative regulation of cytoplasmic translation
M0D48_RS09410	COG0776	regulation of translation
M0D48_RS09420	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M0D48_RS09425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D48_RS09435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M0D48_RS09440	COG0475	glutathione-regulated potassium exporter activity
M0D48_RS09440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D48_RS09450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M0D48_RS09470	COG3002	Belongs to the UPF0753 family
M0D48_RS09475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D48_RS09480	COG0583	DNA-binding transcription factor activity
M0D48_RS09485	COG0583	DNA-binding transcription factor activity
M0D48_RS09490	COG0583	DNA-binding transcription factor activity
M0D48_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS09530	COG2197	response regulator
M0D48_RS09545	COG1335	isochorismatase
M0D48_RS09560	COG2814	Major facilitator Superfamily
M0D48_RS09575	COG1914	H( )-stimulated, divalent metal cation uptake system
M0D48_RS09585	COG0590	tRNA wobble adenosine to inosine editing
M0D48_RS09595	COG0668	transmembrane transport
M0D48_RS09605	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M0D48_RS09620	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS09625	COG1183	phosphatidylcholine synthase activity
M0D48_RS09635	COG3243	poly(R)-hydroxyalkanoic acid synthase
M0D48_RS09650	COG0723	plastoquinol--plastocyanin reductase activity
M0D48_RS09650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_RS09660	COG2183	response to ionizing radiation
M0D48_RS09665	COG2205	protein histidine kinase activity
M0D48_RS09665	COG5002	protein histidine kinase activity
M0D48_RS09665	COG0784	Response regulator, receiver
M0D48_RS09735	COG0129	dihydroxy-acid dehydratase activity
M0D48_RS09740	COG0363	glucosamine-6-phosphate deaminase activity
M0D48_RS09745	COG0837	glucose binding
M0D48_RS09750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D48_RS09775	COG2009	succinate dehydrogenase
M0D48_RS09780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M0D48_RS09795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M0D48_RS09800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M0D48_RS09810	COG4591	ABC-type transport system involved in lipoprotein release permease component
M0D48_RS09830	COG0811	peptide transport
M0D48_RS09845	COG1663	tetraacyldisaccharide 4'-kinase activity
M0D48_RS09850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M0D48_RS09855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M0D48_RS09865	COG0322	excinuclease ABC activity
M0D48_RS09915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M0D48_RS09935	COG1054	Belongs to the UPF0176 family
M0D48_RS09945	COG1530	ribonuclease E activity
M0D48_RS09950	COG0564	pseudouridine synthase activity
M0D48_RS09955	COG3064	Membrane
M0D48_RS09960	COG0428	transporter
M0D48_RS09970	COG2154	pterin-4-alpha-carbinolamine dehydratase
M0D48_RS10075	COG0631	protein serine/threonine phosphatase activity
M0D48_RS10080	COG0515	serine threonine protein kinase
M0D48_RS10105	COG1858	cytochrome C peroxidase
M0D48_RS10130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS10135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_RS10160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D48_RS10165	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS10180	COG0653	protein targeting
M0D48_RS10195	COG0653	protein targeting
M0D48_RS10210	COG0653	protein targeting
M0D48_RS10230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D48_RS10235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D48_RS10240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D48_RS10255	COG1024	Enoyl-CoA hydratase
M0D48_RS10265	COG1024	Enoyl-CoA hydratase
M0D48_RS10270	COG1024	Enoyl-CoA hydratase
M0D48_RS10275	COG3424	synthase
M0D48_RS10285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D48_RS10325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D48_RS10355	COG1304	FMN binding
M0D48_RS10360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M0D48_RS10380	COG0363	glucosamine-6-phosphate deaminase activity
M0D48_RS10400	COG1238	metal cluster binding
M0D48_RS10430	COG3279	Response regulator of the LytR AlgR family
M0D48_RS10435	COG3275	phosphorelay sensor kinase activity
M0D48_RS10470	COG4566	intracellular signal transduction
M0D48_RS10480	COG5001	Diguanylate cyclase
M0D48_RS10510	COG0243	molybdopterin cofactor binding
M0D48_RS10520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D48_RS10525	COG2223	nitrite transmembrane transporter activity
M0D48_RS10530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M0D48_RS10540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M0D48_RS10540	COG1648	precorrin-2 dehydrogenase activity
M0D48_RS10550	COG0746	molybdenum cofactor guanylyltransferase activity
M0D48_RS10555	COG0303	'Molybdopterin
M0D48_RS10565	COG0708	Exodeoxyribonuclease III
M0D48_RS10575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M0D48_RS10580	COG0303	'Molybdopterin
M0D48_RS10585	COG1160	GTP binding
M0D48_RS10590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_RS10610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M0D48_RS10625	COG1250	3-hydroxyacyl-CoA dehydrogenase
M0D48_RS10625	COG1024	Enoyl-CoA hydratase
M0D48_RS10630	COG0183	Belongs to the thiolase family
M0D48_RS10635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M0D48_RS10640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M0D48_RS10660	COG1674	ftsk spoiiie
M0D48_RS10665	COG0492	ferredoxin-NADP+ reductase activity
M0D48_RS10675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M0D48_RS10685	COG0542	response to heat
M0D48_RS10705	COG0482	sulfurtransferase activity
M0D48_RS10745	COG5002	protein histidine kinase activity
M0D48_RS10765	COG0835	chemotaxis
M0D48_RS10765	COG0784	Response regulator, receiver
M0D48_RS10775	COG1558	bacterial-type flagellum-dependent cell motility
M0D48_RS10780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M0D48_RS10790	COG4787	bacterial-type flagellum-dependent cell motility
M0D48_RS10800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M0D48_RS10805	COG1706	bacterial-type flagellum-dependent cell motility
M0D48_RS10810	COG1705	Flagellar rod assembly protein muramidase FlgJ
M0D48_RS10810	COG3951	Flagellar rod assembly protein muramidase FlgJ
M0D48_RS10820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D48_RS10830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D48_RS10835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M0D48_RS10865	COG2201	protein-glutamate methylesterase activity
M0D48_RS10885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS10960	COG1677	Flagellar hook-basal body complex protein FliE
M0D48_RS11010	COG3190	flagellar
M0D48_RS11025	COG1684	flagellar biosynthetic protein fliR
M0D48_RS11080	COG0643	Histidine kinase
M0D48_RS11080	COG0784	Response regulator, receiver
M0D48_RS11080	COG2198	Histidine kinase
M0D48_RS11150	COG0793	Belongs to the peptidase S41A family
M0D48_RS11155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M0D48_RS11160	COG1360	Flagellar Motor Protein
M0D48_RS11165	COG1192	Involved in chromosome partitioning
M0D48_RS11170	COG0835	chemotaxis
M0D48_RS11180	COG0745	RESPONSE REGULATOR receiver
M0D48_RS11190	COG0840	transmembrane signaling receptor activity
M0D48_RS11200	COG0840	transmembrane signaling receptor activity
M0D48_RS11205	COG0840	transmembrane signaling receptor activity
M0D48_RS11215	COG0840	transmembrane signaling receptor activity
M0D48_RS11220	COG0840	transmembrane signaling receptor activity
M0D48_RS11230	COG0840	transmembrane signaling receptor activity
M0D48_RS11235	COG0840	transmembrane signaling receptor activity
M0D48_RS11240	COG0840	transmembrane signaling receptor activity
M0D48_RS11245	COG0840	transmembrane signaling receptor activity
M0D48_RS11250	COG0840	transmembrane signaling receptor activity
M0D48_RS11255	COG0840	transmembrane signaling receptor activity
M0D48_RS11265	COG0835	chemotaxis
M0D48_RS11275	COG0840	transmembrane signaling receptor activity
M0D48_RS11305	COG2267	carboxylic ester hydrolase activity
M0D48_RS11335	COG0318	PFAM AMP-dependent synthetase and ligase
M0D48_RS11340	COG1024	Enoyl-CoA hydratase
M0D48_RS11345	COG0784	Response regulator, receiver
M0D48_RS11345	COG2198	Histidine kinase
M0D48_RS11345	COG2205	protein histidine kinase activity
M0D48_RS11355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M0D48_RS11365	COG3279	Response regulator of the LytR AlgR family
M0D48_RS11380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M0D48_RS11390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D48_RS11395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M0D48_RS11405	COG0505	Belongs to the CarA family
M0D48_RS11410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M0D48_RS11420	COG2258	MOSC domain
M0D48_RS11425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D48_RS11470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M0D48_RS11490	COG0277	FAD linked oxidase domain protein
M0D48_RS11495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D48_RS11505	COG0531	amino acid
M0D48_RS11510	COG0531	amino acid
M0D48_RS11515	COG0235	Class ii aldolase
M0D48_RS11520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M0D48_RS11540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M0D48_RS11540	COG0140	phosphoribosyl-ATP diphosphatase activity
M0D48_RS11545	COG0107	imidazoleglycerol-phosphate synthase activity
M0D48_RS11550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M0D48_RS11555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M0D48_RS11560	COG0131	Imidazoleglycerol-phosphate dehydratase
M0D48_RS11560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M0D48_RS11565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D48_RS11570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M0D48_RS11585	COG0124	histidyl-tRNA synthetase
M0D48_RS11595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D48_RS11605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M0D48_RS11690	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_RS11705	COG0167	dihydroorotate dehydrogenase activity
M0D48_RS11710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M0D48_RS11715	COG0697	spore germination
M0D48_RS11720	COG1794	racemase activity, acting on amino acids and derivatives
M0D48_RS11730	COG0671	phosphoesterase, PA-phosphatase related
M0D48_RS11735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M0D48_RS11745	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M0D48_RS11750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_RS11755	COG2203	Gaf domain
M0D48_RS11755	COG5001	Diguanylate cyclase
M0D48_RS11755	COG4251	negative regulation of phosphorylation
M0D48_RS11755	COG3706	GGDEF domain
M0D48_RS11765	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_RS11795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M0D48_RS11800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M0D48_RS11805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M0D48_RS11815	COG0617	tRNA 3'-terminal CCA addition
M0D48_RS11825	COG1469	GTP cyclohydrolase I activity
M0D48_RS11830	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D48_RS11850	COG0477	Major facilitator Superfamily
M0D48_RS11860	COG1070	Carbohydrate kinase
M0D48_RS11870	COG1501	Belongs to the glycosyl hydrolase 31 family
M0D48_RS11910	COG0800	Aldolase
M0D48_RS11915	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_RS11925	COG3734	2-keto-3-deoxy-galactonokinase
M0D48_RS11930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M0D48_RS11940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D48_RS11955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M0D48_RS11960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M0D48_RS11975	COG0352	thiamine-phosphate diphosphorylase activity
M0D48_RS11975	COG0351	phosphomethylpyrimidine kinase
M0D48_RS12000	COG0583	DNA-binding transcription factor activity
M0D48_RS12005	COG1741	Belongs to the pirin family
M0D48_RS12020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M0D48_RS12025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M0D48_RS12030	COG2137	regulation of response to DNA damage stimulus
M0D48_RS12035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M0D48_RS12045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D48_RS12050	COG1546	Belongs to the CinA family
M0D48_RS12055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M0D48_RS12070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M0D48_RS12075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M0D48_RS12080	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M0D48_RS12085	COG1534	Rna-binding protein
M0D48_RS12090	COG3737	Protein of unknown function (DUF498/DUF598)
M0D48_RS12100	COG1238	metal cluster binding
M0D48_RS12105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D48_RS12110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M0D48_RS12115	COG2840	Smr protein MutS2
M0D48_RS12120	COG0585	pseudouridine synthase activity
M0D48_RS12125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M0D48_RS12135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M0D48_RS12140	COG0148	phosphopyruvate hydratase activity
M0D48_RS12155	COG0504	CTP synthase activity
M0D48_RS12180	COG0306	phosphate transporter
M0D48_RS12190	COG1253	flavin adenine dinucleotide binding
M0D48_RS12205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M0D48_RS12210	COG0477	Major facilitator Superfamily
M0D48_RS12215	COG1132	(ABC) transporter
M0D48_RS12220	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D48_RS12235	COG0438	transferase activity, transferring glycosyl groups
M0D48_RS12245	COG2264	protein methyltransferase activity
M0D48_RS12250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M0D48_RS12275	COG2244	polysaccharide biosynthetic process
M0D48_RS12340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D48_RS12350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D48_RS12360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D48_RS12375	COG0784	Response regulator, receiver
M0D48_RS12375	COG4191	Histidine kinase
M0D48_RS12380	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D48_RS12385	COG0784	Response regulator, receiver
M0D48_RS12385	COG2205	protein histidine kinase activity
M0D48_RS12385	COG5002	protein histidine kinase activity
M0D48_RS12405	COG0840	transmembrane signaling receptor activity
M0D48_RS12480	COG2003	Belongs to the UPF0758 family
M0D48_RS12570	COG0583	DNA-binding transcription factor activity
M0D48_RS12575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M0D48_RS12580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M0D48_RS12595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M0D48_RS12600	COG1605	Chorismate mutase
M0D48_RS12600	COG0077	Prephenate dehydratase
M0D48_RS12605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M0D48_RS12610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M0D48_RS12615	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M0D48_RS12650	COG1228	amidohydrolase
M0D48_RS12655	COG2986	histidine ammonia-lyase
M0D48_RS12665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M0D48_RS12680	COG4993	Dehydrogenase
M0D48_RS12695	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M0D48_RS12710	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M0D48_RS12715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M0D48_RS12720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D48_RS12730	COG3115	cell septum assembly
M0D48_RS12750	COG0360	Binds together with S18 to 16S ribosomal RNA
M0D48_RS12755	COG0316	Belongs to the HesB IscA family
M0D48_RS12760	COG0017	Asparaginyl-tRNA synthetase
M0D48_RS12785	COG0288	reversible hydration of carbon dioxide
M0D48_RS12800	COG3844	kynureninase activity
M0D48_RS12805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D48_RS12810	COG2925	Exonuclease
M0D48_RS12820	COG0667	Aldo Keto reductase
M0D48_RS12835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M0D48_RS12840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D48_RS12840	COG0116	Belongs to the methyltransferase superfamily
M0D48_RS12890	COG1024	Enoyl-CoA hydratase
M0D48_RS12900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M0D48_RS12905	COG0659	secondary active sulfate transmembrane transporter activity
M0D48_RS12930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M0D48_RS12935	COG0573	inorganic phosphate transmembrane transporter activity
M0D48_RS12940	COG0581	inorganic phosphate transmembrane transporter activity
M0D48_RS12950	COG0704	Plays a role in the regulation of phosphate uptake
M0D48_RS12960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D48_RS12970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D48_RS12980	COG0557	exoribonuclease II activity
M0D48_RS12995	COG1960	acyl-CoA dehydrogenase activity
M0D48_RS13000	COG2226	methyltransferase
M0D48_RS13005	COG0646	methionine synthase
M0D48_RS13005	COG1410	methionine synthase
M0D48_RS13015	COG0646	methionine synthase
M0D48_RS13015	COG1410	methionine synthase
M0D48_RS13025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_RS13050	COG2900	Belongs to the SlyX family
M0D48_RS13065	COG0386	Belongs to the glutathione peroxidase family
M0D48_RS13075	COG1725	Transcriptional regulator
M0D48_RS13080	COG1131	(ABC) transporter
M0D48_RS13115	COG1253	flavin adenine dinucleotide binding
M0D48_RS13140	COG2850	peptidyl-arginine hydroxylation
M0D48_RS13180	COG1132	(ABC) transporter
M0D48_RS13190	COG0583	DNA-binding transcription factor activity
M0D48_RS13220	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M0D48_RS13235	COG0443	Heat shock 70 kDa protein
M0D48_RS13240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M0D48_RS13245	COG1420	regulation of RNA biosynthetic process
M0D48_RS13250	COG0497	DNA recombination
M0D48_RS13260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_RS13265	COG2914	Belongs to the UPF0125 (RnfH) family
M0D48_RS13275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M0D48_RS13345	COG2814	Major facilitator Superfamily
M0D48_RS13485	COG2003	Belongs to the UPF0758 family
M0D48_RS13560	COG3706	GGDEF domain
M0D48_RS13590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_RS13605	COG0583	DNA-binding transcription factor activity
M0D48_RS13615	COG0415	Belongs to the DNA photolyase family
M0D48_RS13620	COG0305	Participates in initiation and elongation during chromosome replication
M0D48_RS13630	COG0367	asparagine synthase
M0D48_RS13650	COG1960	acyl-CoA dehydrogenase activity
M0D48_RS13665	COG0084	hydrolase, TatD family'
M0D48_RS13670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M0D48_RS13710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D48_RS13765	COG0386	Belongs to the glutathione peroxidase family
M0D48_RS13770	COG0339	signal peptide processing
M0D48_RS13850	COG2814	Major facilitator Superfamily
M0D48_RS13855	COG1566	PFAM secretion protein HlyD family protein
M0D48_RS13880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M0D48_RS13900	COG0300	oxidoreductase activity
M0D48_RS13905	COG4774	siderophore transport
M0D48_RS13915	COG0367	asparagine synthase
M0D48_RS13920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D48_RS13930	COG1393	Belongs to the ArsC family
M0D48_RS13945	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M0D48_RS13990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M0D48_RS14000	COG0528	UMP kinase activity
M0D48_RS14005	COG0233	cytoplasmic translational termination
M0D48_RS14015	COG0575	Belongs to the CDS family
M0D48_RS14020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M0D48_RS14025	COG0750	zinc metalloprotease
M0D48_RS14040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_RS14050	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_RS14055	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_RS14060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M0D48_RS14070	COG0825	malonyl-CoA metabolic process
M0D48_RS14095	COG1981	membrane
M0D48_RS14115	COG1695	Transcriptional regulator
M0D48_RS14135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D48_RS14155	COG2040	homocysteine
M0D48_RS14160	COG0833	amino acid
M0D48_RS14165	COG0346	lactoylglutathione lyase activity
M0D48_RS14170	COG1131	(ABC) transporter
M0D48_RS14185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D48_RS14185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D48_RS14195	COG2878	Part of a membrane complex involved in electron transport
M0D48_RS14210	COG1595	DNA-templated transcription, initiation
M0D48_RS14235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D48_RS14250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D48_RS14255	COG0251	oxidation-reduction process
M0D48_RS14265	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M0D48_RS14265	COG0392	lysyltransferase activity
M0D48_RS14300	COG2814	Major facilitator Superfamily
M0D48_RS14305	COG1902	pentaerythritol trinitrate reductase activity
M0D48_RS14315	COG2824	Alkylphosphonate utilization operon protein PhnA
M0D48_RS14325	COG1047	Peptidyl-prolyl cis-trans
M0D48_RS14360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M0D48_RS14370	COG5487	UPF0391 membrane protein
M0D48_RS14375	COG1451	nucleotide metabolic process
M0D48_RS14400	COG0183	Belongs to the thiolase family
M0D48_RS14430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M0D48_RS14430	COG1793	dna ligase
M0D48_RS14440	COG1793	dna ligase
M0D48_RS14445	COG1201	RNA secondary structure unwinding
M0D48_RS14465	COG1278	Cold shock
M0D48_RS14470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M0D48_RS14475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M0D48_RS14480	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_RS14485	COG3046	protein related to deoxyribodipyrimidine photolyase
M0D48_RS14490	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M0D48_RS14495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M0D48_RS14500	COG2954	triphosphatase activity
M0D48_RS14515	COG1381	Involved in DNA repair and RecF pathway recombination
M0D48_RS14525	COG0571	ribonuclease III activity
M0D48_RS14540	COG0481	GTPase activity
M0D48_RS14545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D48_RS14585	COG1024	Enoyl-CoA hydratase
M0D48_RS14590	COG1960	acyl-CoA dehydrogenase activity
M0D48_RS14610	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M0D48_RS14615	COG3250	beta-galactosidase activity
M0D48_RS14630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M0D48_RS14635	COG1121	(ABC) transporter
M0D48_RS14645	COG0803	Belongs to the bacterial solute-binding protein 9 family
M0D48_RS14650	COG0523	cobalamin synthesis protein
M0D48_RS14660	COG4774	siderophore transport
M0D48_RS14680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M0D48_RS14690	COG0534	Mate efflux family protein
M0D48_RS14700	COG0336	Belongs to the RNA methyltransferase TrmD family
M0D48_RS14705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M0D48_RS14710	COG0228	four-way junction DNA binding
M0D48_RS14720	COG2070	2-Nitropropane dioxygenase
M0D48_RS14730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M0D48_RS14735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D48_RS14750	COG0583	DNA-binding transcription factor activity
M0D48_RS14770	COG4191	Histidine kinase
M0D48_RS14770	COG0784	Response regulator, receiver
M0D48_RS14775	COG4999	Histidine kinase
M0D48_RS14775	COG3850	Histidine kinase
M0D48_RS14775	COG2205	protein histidine kinase activity
M0D48_RS14775	COG3437	response regulator, receiver
M0D48_RS14780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D48_RS14795	COG5507	3-demethylubiquinone-9 3-methyltransferase
M0D48_RS14805	COG4771	TonB-dependent receptor
M0D48_RS14830	COG2172	sigma factor antagonist activity
M0D48_RS14835	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D48_RS14840	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D48_RS14850	COG0326	Molecular chaperone. Has ATPase activity
M0D48_RS14855	COG2207	Transcriptional regulator
M0D48_RS14865	COG3152	Membrane
M0D48_RS14875	COG0156	8-amino-7-oxononanoate synthase activity
M0D48_RS14885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M0D48_RS14890	COG1845	cytochrome c oxidase, subunit III
M0D48_RS14895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M0D48_RS14915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M0D48_RS14920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M0D48_RS14925	COG0196	riboflavin kinase activity
M0D48_RS14935	COG0268	Binds directly to 16S ribosomal RNA
M0D48_RS14945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M0D48_RS14955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M0D48_RS14960	COG0824	Thioesterase
M0D48_RS14975	COG1946	Acyl-CoA thioesterase
M0D48_RS14985	COG1595	DNA-templated transcription, initiation
M0D48_RS15000	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M0D48_RS15020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M0D48_RS15045	COG1073	alpha beta
M0D48_RS15065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M0D48_RS15080	COG2197	response regulator
M0D48_RS15085	COG4585	Histidine kinase
M0D48_RS15100	COG2894	cell division
M0D48_RS15105	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M0D48_RS15115	COG0642	Histidine kinase
M0D48_RS15120	COG0745	RESPONSE REGULATOR receiver
M0D48_RS15125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M0D48_RS15135	COG2194	sulfuric ester hydrolase activity
M0D48_RS15150	COG2814	Major facilitator Superfamily
M0D48_RS15175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D48_RS15175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D48_RS15185	COG0656	L-ascorbic acid biosynthetic process
M0D48_RS15190	COG0753	catalase activity
M0D48_RS15215	COG1917	Cupin 2, conserved barrel domain protein
M0D48_RS15215	COG2207	Transcriptional regulator
M0D48_RS15225	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_RS15225	COG1506	peptidase
M0D48_RS15235	COG1297	OPT oligopeptide transporter protein
M0D48_RS15260	COG0587	DNA-directed DNA polymerase activity
M0D48_RS15310	COG2080	2 iron, 2 sulfur cluster binding
M0D48_RS15315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D48_RS15320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D48_RS15330	COG1064	alcohol dehydrogenase
M0D48_RS15365	COG3537	Alpha-1,2-mannosidase
M0D48_RS15375	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS15415	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M0D48_RS15425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M0D48_RS15430	COG0732	type I restriction modification DNA specificity domain
M0D48_RS15445	COG1309	transcriptional regulator
M0D48_RS15450	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS15465	COG0308	aminopeptidase N
M0D48_RS15485	COG0330	HflC and HflK could
M0D48_RS15490	COG0330	HflC and HflK could
M0D48_RS15510	COG0678	peroxiredoxin activity
M0D48_RS15520	COG4953	penicillin-binding protein 1C
M0D48_RS15535	COG2373	Large extracellular alpha-helical protein
M0D48_RS15560	COG3609	addiction module antidote protein, CC2985 family
M0D48_RS15580	COG3829	transcription factor binding
M0D48_RS15605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M0D48_RS15610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M0D48_RS15625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D48_RS15645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_RS15650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M0D48_RS15655	COG1399	metal-binding, possibly nucleic acid-binding protein
M0D48_RS15675	COG0714	Associated with various cellular activities
M0D48_RS15695	COG0537	adenosine 5'-monophosphoramidase activity
M0D48_RS15705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M0D48_RS15765	COG0314	molybdopterin synthase activity
M0D48_RS15770	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M0D48_RS15775	COG0315	cyclic pyranopterin monophosphate synthase activity
M0D48_RS15785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M0D48_RS15795	COG3642	lipopolysaccharide core region biosynthetic process
M0D48_RS15800	COG0859	PFAM glycosyl transferase family 9
M0D48_RS15815	COG0631	protein serine/threonine phosphatase activity
M0D48_RS15825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D48_RS15850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M0D48_RS15880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M0D48_RS15890	COG0544	peptidyl-prolyl cis-trans isomerase activity
M0D48_RS15900	COG4191	Histidine kinase
M0D48_RS15900	COG0784	Response regulator, receiver
M0D48_RS15935	COG0473	3-isopropylmalate dehydrogenase activity
M0D48_RS15950	COG4783	chaperone-mediated protein folding
M0D48_RS15965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M0D48_RS15975	COG0438	transferase activity, transferring glycosyl groups
M0D48_RS15980	COG0671	phosphoesterase, PA-phosphatase related
M0D48_RS15985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_RS15995	COG3291	Pkd domain containing protein
M0D48_RS16000	COG2833	Protein of unknown function (DUF455)
M0D48_RS16025	COG0285	dihydrofolate synthase activity
M0D48_RS16040	COG0406	alpha-ribazole phosphatase activity
M0D48_RS16070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M0D48_RS16075	COG4208	sulfate ABC transporter
M0D48_RS16080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M0D48_RS16085	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M0D48_RS16090	COG0156	8-amino-7-oxononanoate synthase activity
M0D48_RS16110	COG2885	chlorophyll binding
M0D48_RS16115	COG0604	alcohol dehydrogenase
M0D48_RS16120	COG0446	pyridine nucleotide-disulphide oxidoreductase
M0D48_RS16120	COG1902	pentaerythritol trinitrate reductase activity
M0D48_RS16135	COG0625	glutathione transferase activity
M0D48_RS16145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M0D48_RS16150	COG1217	gtp-binding protein TYPA
M0D48_RS16160	COG0154	amidase activity
M0D48_RS16170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M0D48_RS16180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M0D48_RS16185	COG0203	ribosomal protein L17
M0D48_RS16210	COG0201	protein transport
M0D48_RS16215	COG0200	Binds to the 23S rRNA
M0D48_RS16220	COG1841	ribosomal large subunit assembly
M0D48_RS16235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M0D48_RS16255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M0D48_RS16265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M0D48_RS16270	COG0255	Belongs to the universal ribosomal protein uL29 family
M0D48_RS16285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M0D48_RS16295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M0D48_RS16305	COG0088	Forms part of the polypeptide exit tunnel
M0D48_RS16315	COG0051	transcription antitermination factor activity, RNA binding
M0D48_RS16330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D48_RS16335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M0D48_RS16340	COG0049	tRNA binding
M0D48_RS16345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M0D48_RS16350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M0D48_RS16355	COG0085	RNA polymerase activity
M0D48_RS16365	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M0D48_RS16370	COG0081	regulation of translation
M0D48_RS16375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M0D48_RS16380	COG0250	Participates in transcription elongation, termination and antitermination
M0D48_RS16385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M0D48_RS16395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D48_RS16415	COG0012	GTP binding
M0D48_RS16420	COG0193	aminoacyl-tRNA hydrolase activity
M0D48_RS16425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M0D48_RS16430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M0D48_RS16445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M0D48_RS16455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M0D48_RS16460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M0D48_RS16470	COG0521	Mo-molybdopterin cofactor biosynthetic process
M0D48_RS16490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D48_RS16495	COG1295	ribonuclease BN
M0D48_RS16525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M0D48_RS16530	COG1404	Belongs to the peptidase S8 family
M0D48_RS16535	COG1404	Belongs to the peptidase S8 family
M0D48_RS16540	COG1404	Belongs to the peptidase S8 family
M0D48_RS16545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M0D48_RS16560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M0D48_RS16585	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M0D48_RS16655	COG3634	alkyl hydroperoxide reductase activity
M0D48_RS16660	COG0583	DNA-binding transcription factor activity
M0D48_RS16670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D48_RS16675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M0D48_RS16685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M0D48_RS16695	COG2197	response regulator
M0D48_RS16700	COG5002	protein histidine kinase activity
M0D48_RS16700	COG2205	protein histidine kinase activity
M0D48_RS16700	COG0784	Response regulator, receiver
M0D48_RS16720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D48_RS16725	COG0697	spore germination
M0D48_RS16770	COG1024	Enoyl-CoA hydratase
M0D48_RS16780	COG0318	PFAM AMP-dependent synthetase and ligase
M0D48_RS16785	COG0583	DNA-binding transcription factor activity
M0D48_RS16790	COG3384	dioxygenase
M0D48_RS16800	COG1802	Transcriptional regulator
M0D48_RS16815	COG2267	carboxylic ester hydrolase activity
M0D48_RS16820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D48_RS16825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D48_RS16840	COG2096	Adenosyltransferase
M0D48_RS16845	COG0123	including yeast histone deacetylase and acetoin utilization protein
M0D48_RS16850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M0D48_RS16860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M0D48_RS16865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M0D48_RS16870	COG2967	ApaG domain
M0D48_RS16875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M0D48_RS16895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M0D48_RS16915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M0D48_RS16925	COG0642	Histidine kinase
M0D48_RS16940	COG4181	ATPase activity
M0D48_RS16950	COG2175	clavaminate synthase activity
M0D48_RS16960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M0D48_RS16965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M0D48_RS16985	COG4771	TonB-dependent receptor
M0D48_RS16995	COG0667	Aldo Keto reductase
M0D48_RS17000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M0D48_RS17005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_RS17020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D48_RS17025	COG4106	trans-aconitate 2-methyltransferase activity
M0D48_RS17035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M0D48_RS17075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M0D48_RS17090	COG2226	methyltransferase
M0D48_RS17130	COG0366	Alpha amylase catalytic
M0D48_RS17150	COG0604	alcohol dehydrogenase
M0D48_RS17150	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS17150	COG3321	synthase
M0D48_RS17160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M0D48_RS17170	COG0494	nUDIX hydrolase
M0D48_RS17180	COG0653	protein targeting
M0D48_RS17185	COG0739	heme binding
M0D48_RS17195	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M0D48_RS17210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M0D48_RS17215	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D48_RS17220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D48_RS17225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M0D48_RS17235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D48_RS17240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M0D48_RS17255	COG3116	cell division
M0D48_RS17300	COG0792	nuclease activity
M0D48_RS17305	COG1988	membrane-bound metal-dependent
M0D48_RS17310	COG0277	FAD linked oxidase domain protein
M0D48_RS17325	COG0745	RESPONSE REGULATOR receiver
M0D48_RS17330	COG2205	protein histidine kinase activity
M0D48_RS17340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M0D48_RS17345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M0D48_RS17365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M0D48_RS17370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D48_RS17375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M0D48_RS17395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D48_RS17395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D48_RS17410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M0D48_RS17425	COG0488	(ABC) transporter
M0D48_RS17430	COG0242	peptide deformylase activity
M0D48_RS17455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M0D48_RS17500	COG2188	Transcriptional regulator
M0D48_RS17510	COG1450	Type ii and iii secretion system protein
M0D48_RS17525	COG3166	PFAM Fimbrial assembly family protein
M0D48_RS17530	COG3156	type II secretion system protein K
M0D48_RS17535	COG4795	General secretion pathway protein
M0D48_RS17540	COG2165	general secretion pathway protein
M0D48_RS17545	COG4970	Tfp pilus assembly protein FimT
M0D48_RS17550	COG2165	general secretion pathway protein
M0D48_RS17555	COG1459	type II secretion system
M0D48_RS17560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D48_RS17565	COG1404	Belongs to the peptidase S8 family
M0D48_RS17570	COG5295	Hep Hag repeat protein
M0D48_RS17580	COG0047	phosphoribosylformylglycinamidine synthase activity
M0D48_RS17580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M0D48_RS17585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D48_RS17590	COG4974	Belongs to the 'phage' integrase family
M0D48_RS17610	COG0795	lipopolysaccharide-transporting ATPase activity
M0D48_RS17620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D48_RS17635	COG0525	valine-tRNA ligase activity
M0D48_RS17665	COG0726	polysaccharide deacetylase
M0D48_RS17665	COG1649	PFAM Uncharacterised BCR, COG1649
M0D48_RS17670	COG1215	transferase activity, transferring glycosyl groups
M0D48_RS17685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M0D48_RS17690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D48_RS17695	COG1609	Transcriptional regulator
M0D48_RS17705	COG2188	Transcriptional regulator
M0D48_RS17720	COG3250	beta-galactosidase activity
M0D48_RS17750	COG4795	General secretion pathway protein
M0D48_RS17770	COG1459	type II secretion system
M0D48_RS17825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M0D48_RS17830	COG4191	Histidine kinase
M0D48_RS17835	COG0784	Response regulator, receiver
M0D48_RS17840	COG4251	negative regulation of phosphorylation
M0D48_RS17845	COG2823	Periplasmic or secreted lipoprotein
M0D48_RS17850	COG0673	inositol 2-dehydrogenase activity
M0D48_RS17855	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M0D48_RS17890	COG1051	belongs to the nudix hydrolase family
M0D48_RS17890	COG1056	cytidyltransferase-related domain
M0D48_RS17900	COG0583	DNA-binding transcription factor activity
M0D48_RS17915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M0D48_RS17920	COG0321	lipoyl(octanoyl) transferase activity
M0D48_RS17925	COG2921	Belongs to the UPF0250 family
M0D48_RS17935	COG1686	Belongs to the peptidase S11 family
M0D48_RS17940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M0D48_RS17945	COG2951	lytic endotransglycosylase activity
M0D48_RS17950	COG5434	Belongs to the glycosyl hydrolase 28 family
M0D48_RS17960	COG0772	Belongs to the SEDS family
M0D48_RS17975	COG1792	Involved in formation and maintenance of cell shape
M0D48_RS17985	COG1077	Cell shape determining protein MreB Mrl
M0D48_RS17990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_RS18005	COG3284	Transcriptional regulator
M0D48_RS18050	COG0308	aminopeptidase N
M0D48_RS18055	COG5001	Diguanylate cyclase
M0D48_RS18055	COG3300	MHYT domain
M0D48_RS18060	COG2226	methyltransferase
M0D48_RS18075	COG2153	protein acetylation
M0D48_RS18085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M0D48_RS18095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M0D48_RS18105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M0D48_RS18115	COG2832	Protein of unknown function (DUF454)
M0D48_RS18125	COG0436	Aminotransferase
M0D48_RS18140	COG1505	serine-type exopeptidase activity
M0D48_RS18165	COG0181	hydroxymethylbilane synthase activity
M0D48_RS18175	COG3275	phosphorelay sensor kinase activity
M0D48_RS18185	COG2943	transferase activity, transferring hexosyl groups
M0D48_RS18200	COG0659	secondary active sulfate transmembrane transporter activity
M0D48_RS18205	COG5297	Belongs to the glycosyl hydrolase family 6
M0D48_RS18205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_RS18210	COG0840	transmembrane signaling receptor activity
M0D48_RS18275	COG0598	Magnesium transport protein CorA
M0D48_RS18285	COG1113	amino acid transport
M0D48_RS18295	COG5297	Belongs to the glycosyl hydrolase family 6
M0D48_RS18300	COG4305	rare lipoprotein A
M0D48_RS18305	COG0697	spore germination
M0D48_RS18370	COG0435	Glutathione S-transferase
M0D48_RS18380	COG4221	oxidoreductase activity
M0D48_RS18425	COG0210	DNA helicase
M0D48_RS18530	COG1802	Transcriptional regulator
M0D48_RS18540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M0D48_RS18565	COG3052	prosthetic group binding
M0D48_RS18600	COG1595	DNA-templated transcription, initiation
M0D48_RS18605	COG2353	YceI-like domain
M0D48_RS18610	COG0778	Nitroreductase
M0D48_RS18635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D48_RS18640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M0D48_RS18650	COG3386	PFAM SMP-30 Gluconolaconase
M0D48_RS18665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M0D48_RS18680	COG3039	Transposase
M0D48_RS18715	COG0459	protein refolding
M0D48_RS18725	COG2356	endonuclease I
M0D48_RS18730	COG1324	tolerance protein
M0D48_RS18740	COG1505	serine-type exopeptidase activity
M0D48_RS18745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M0D48_RS18750	COG0511	ligase activity, forming carbon-carbon bonds
M0D48_RS18760	COG0439	Biotin carboxylase
M0D48_RS18805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M0D48_RS18820	COG0138	bifunctional purine biosynthesis protein purh
M0D48_RS18825	COG0151	Belongs to the GarS family
M0D48_RS18830	COG1289	transmembrane transporter activity
M0D48_RS18835	COG2814	Major facilitator Superfamily
M0D48_RS18845	COG2814	Major facilitator Superfamily
M0D48_RS18860	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D48_RS18875	COG0316	Belongs to the HesB IscA family
M0D48_RS18930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M0D48_RS18940	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M0D48_RS18955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D48_RS18965	COG0134	indole-3-glycerol-phosphate synthase activity
M0D48_RS18970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M0D48_RS19000	COG1597	lipid kinase activity
M0D48_RS19005	COG0456	acetyltransferase
M0D48_RS19010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M0D48_RS19020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M0D48_RS19060	COG2111	Na H antiporter
M0D48_RS19060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D48_RS19065	COG1006	Multisubunit Na H antiporter MnhC subunit
M0D48_RS19070	COG0651	ATP synthesis coupled electron transport
M0D48_RS19080	COG2212	antiporter activity
M0D48_RS19085	COG1320	monovalent cation:proton antiporter activity
M0D48_RS19105	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M0D48_RS19125	COG3104	oligopeptide transport
M0D48_RS19140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M0D48_RS19165	COG0513	Belongs to the DEAD box helicase family
M0D48_RS19185	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS19205	COG0702	epimerase
M0D48_RS19230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D48_RS19235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D48_RS19240	COG0297	glycogen (starch) synthase activity
M0D48_RS19250	COG1649	PFAM Uncharacterised BCR, COG1649
M0D48_RS19255	COG2354	Protein conserved in bacteria
M0D48_RS19260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D48_RS19265	COG1368	sulfuric ester hydrolase activity
M0D48_RS19270	COG1511	domain protein
M0D48_RS19270	COG3264	Mechanosensitive ion channel
M0D48_RS19345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M0D48_RS19425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D48_RS19430	COG1040	competence protein
M0D48_RS19435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M0D48_RS19440	COG0156	8-amino-7-oxononanoate synthase activity
M0D48_RS19455	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS19480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D48_RS19495	COG0445	tRNA wobble uridine modification
M0D48_RS19505	COG0657	acetylesterase activity
M0D48_RS19515	COG1414	Transcriptional regulator
M0D48_RS19530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M0D48_RS19535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D48_RS19545	COG3485	protocatechuate 3,4-dioxygenase
M0D48_RS19550	COG3485	protocatechuate 3,4-dioxygenase
M0D48_RS19560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M0D48_RS19565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M0D48_RS19595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M0D48_RS19600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M0D48_RS19655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M0D48_RS19665	COG0129	dihydroxy-acid dehydratase activity
M0D48_RS19710	COG1733	regulation of RNA biosynthetic process
M0D48_RS19715	COG0702	epimerase
M0D48_RS19745	COG0583	DNA-binding transcription factor activity
M0D48_RS19750	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M0D48_RS19805	COG1902	pentaerythritol trinitrate reductase activity
M0D48_RS19810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M0D48_RS19815	COG0596	Alpha beta hydrolase
M0D48_RS19830	COG2814	Major facilitator Superfamily
M0D48_RS19835	COG0583	DNA-binding transcription factor activity
M0D48_RS19840	COG0084	hydrolase, TatD family'
M0D48_RS19860	COG2252	PERMEase
M0D48_RS19905	COG0596	Alpha beta hydrolase
M0D48_RS19920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M0D48_RS19940	COG2072	flavoprotein involved in K transport
M0D48_RS19945	COG2351	hydroxyisourate hydrolase activity
M0D48_RS19950	COG4807	Protein conserved in bacteria
M0D48_RS19960	COG1643	Atp-dependent helicase
M0D48_RS19970	COG1187	pseudouridine synthase activity
M0D48_RS19985	COG2130	NADP-dependent
M0D48_RS19990	COG0656	L-ascorbic acid biosynthetic process
M0D48_RS20010	COG1764	response to oxidative stress
M0D48_RS20015	COG1846	Transcriptional regulator
M0D48_RS20020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M0D48_RS20030	COG0697	spore germination
M0D48_RS20040	COG0523	cobalamin synthesis protein
M0D48_RS20095	COG1960	acyl-CoA dehydrogenase activity
M0D48_RS20100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M0D48_RS20105	COG4770	biotin carboxylase activity
M0D48_RS20135	COG2224	Isocitrate lyase
M0D48_RS20140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M0D48_RS20145	COG0583	DNA-binding transcription factor activity
M0D48_RS20150	COG0475	glutathione-regulated potassium exporter activity
M0D48_RS20180	COG0681	Belongs to the peptidase S26 family
M0D48_RS20185	COG0339	signal peptide processing
M0D48_RS20190	COG1446	asparaginase
M0D48_RS20210	COG0564	pseudouridine synthase activity
M0D48_RS20225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D48_RS20235	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D48_RS20245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D48_RS20250	COG0318	PFAM AMP-dependent synthetase and ligase
M0D48_RS20255	COG0727	PFAM Uncharacterised protein family (UPF0153)
M0D48_RS20260	COG0596	Alpha beta hydrolase
M0D48_RS20270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_RS20285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M0D48_RS20310	COG2205	protein histidine kinase activity
M0D48_RS20315	COG0028	Belongs to the TPP enzyme family
M0D48_RS20325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M0D48_RS20330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M0D48_RS20335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M0D48_RS20375	COG0183	Belongs to the thiolase family
M0D48_RS20390	COG2032	superoxide dismutase activity
M0D48_RS20395	COG2032	superoxide dismutase activity
M0D48_RS20400	COG2204	response regulator
M0D48_RS20405	COG3852	Histidine kinase
M0D48_RS20410	COG0004	ammonium transporteR
M0D48_RS20415	COG0347	Belongs to the P(II) protein family
M0D48_RS20420	COG0174	glutamine synthetase
M0D48_RS20425	COG1968	undecaprenyl-diphosphatase activity
M0D48_RS20465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_RS20475	COG2062	phosphohistidine phosphatase, SixA
M0D48_RS20480	COG0489	protein tyrosine kinase activity
M0D48_RS20500	COG3620	sequence-specific DNA binding
M0D48_RS20505	COG3550	peptidyl-serine autophosphorylation
M0D48_RS20510	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M0D48_RS20515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D48_RS20530	COG0517	IMP dehydrogenase activity
M0D48_RS20530	COG1125	glycine betaine transport
M0D48_RS20545	COG1119	ATPase activity
M0D48_RS20555	COG1473	amidohydrolase
M0D48_RS20560	COG1752	Esterase of the alpha-beta hydrolase superfamily
M0D48_RS20570	COG1522	sequence-specific DNA binding
M0D48_RS20575	COG3186	Phenylalanine-4-hydroxylase
M0D48_RS20585	COG2755	lipolytic protein G-D-S-L family
M0D48_RS20595	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_RS20600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M0D48_RS20605	COG1609	Transcriptional regulator
M0D48_RS20625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M0D48_RS20635	COG0657	acetylesterase activity
M0D48_RS20635	COG2755	lipolytic protein G-D-S-L family
M0D48_RS20645	COG2755	lipolytic protein G-D-S-L family
M0D48_RS20685	COG0366	Alpha amylase catalytic
M0D48_RS20690	COG0366	Alpha amylase catalytic
M0D48_RS20695	COG2831	hemolysin activation secretion protein
M0D48_RS20700	COG3210	domain, Protein
M0D48_RS20710	COG3210	domain, Protein
M0D48_RS20725	COG3210	domain, Protein
M0D48_RS20765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D48_RS20805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_RS20815	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M0D48_RS20820	COG3710	Transcriptional regulator
M0D48_RS20840	COG2197	response regulator
M0D48_RS20845	COG4585	Histidine kinase
M0D48_RS20850	COG1755	Isoprenylcysteine carboxyl methyltransferase
M0D48_RS20855	COG1304	FMN binding
M0D48_RS20880	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_RS20885	COG4772	TonB-dependent receptor
M0D48_RS20895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M0D48_RS20945	COG0714	Associated with various cellular activities
M0D48_RS20985	COG0477	Major facilitator Superfamily
M0D48_RS20990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D48_RS21050	COG3237	CsbD-like
M0D48_RS21060	COG0625	glutathione transferase activity
M0D48_RS21070	COG1272	protein, Hemolysin III
M0D48_RS21075	COG1205	dead DEAH box helicase
M0D48_RS21075	COG1111	helicase
M0D48_RS21155	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M0D48_RS21185	COG1132	(ABC) transporter
M0D48_RS21215	COG0367	asparagine synthase
M0D48_RS21235	COG0438	transferase activity, transferring glycosyl groups
M0D48_RS21235	COG0297	glycogen (starch) synthase activity
M0D48_RS21240	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M0D48_RS21260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M0D48_RS21280	COG3459	Glycosyltransferase 36 associated
M0D48_RS21315	COG0067	glutamate synthase
M0D48_RS21315	COG0069	glutamate synthase activity
M0D48_RS21315	COG0070	glutamate synthase
M0D48_RS21320	COG0493	'glutamate synthase
M0D48_RS21335	COG1064	alcohol dehydrogenase
M0D48_RS21340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_RS21345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_RS21350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_RS21360	COG2234	aminopeptidase activity
M0D48_RS21370	COG4942	peptidase
M0D48_RS21375	COG0793	Belongs to the peptidase S41A family
M0D48_RS21380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D48_RS21420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_RS21430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M0D48_RS21465	COG0501	Belongs to the peptidase M48B family
M0D48_RS21475	COG0187	DNA topoisomerase II activity
M0D48_RS21490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M0D48_RS21510	COG0726	polysaccharide deacetylase
M0D48_RS21515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M0D48_RS21530	COG0584	glycerophosphoryl diester phosphodiesterase
M0D48_RS21540	COG0861	Integral membrane protein TerC family
M0D48_RS21545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D48_RS21560	COG2271	Major facilitator Superfamily
M0D48_RS21565	COG1929	Belongs to the glycerate kinase type-1 family
M0D48_RS21570	COG3835	regulator
M0D48_RS21575	COG3706	GGDEF domain
M0D48_RS21595	COG3537	Alpha-1,2-mannosidase
M0D48_RS21600	COG0531	amino acid
M0D48_RS21620	COG0583	DNA-binding transcription factor activity
M0D48_RS21625	COG0604	alcohol dehydrogenase
M0D48_RS21630	COG1322	Protein conserved in bacteria
M0D48_RS21640	COG0386	Belongs to the glutathione peroxidase family
M0D48_RS21650	COG2853	Lipoprotein
M0D48_RS21670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D48_RS21675	COG1127	ABC transporter
M0D48_RS21680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M0D48_RS21685	COG1074	ATP-dependent DNA helicase activity
M0D48_RS21730	COG0564	pseudouridine synthase activity
M0D48_RS21775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_RS21810	COG0477	Major facilitator Superfamily
M0D48_RS21815	COG1289	transmembrane transporter activity
M0D48_RS21825	COG1566	PFAM secretion protein HlyD family protein
M0D48_RS21840	COG0302	gtp cyclohydrolase
M0D48_RS21860	COG0730	response to heat
M0D48_RS21865	COG3012	SEC-C Motif Domain Protein
M0D48_RS21875	COG0676	glucose-6-phosphate 1-epimerase activity
M0D48_RS21895	COG3135	benzoate transporter