locus-tag	class	description
H7A87_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7A87_RS00020	COG0187	DNA topoisomerase II activity
H7A87_RS00030	COG0501	Belongs to the peptidase M48B family
H7A87_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7A87_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7A87_RS00105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7A87_RS00110	COG0793	Belongs to the peptidase S41A family
H7A87_RS00115	COG4942	peptidase
H7A87_RS00125	COG2234	aminopeptidase activity
H7A87_RS00135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7A87_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7A87_RS00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7A87_RS00150	COG1064	alcohol dehydrogenase
H7A87_RS00160	COG0493	'glutamate synthase
H7A87_RS00165	COG0069	glutamate synthase activity
H7A87_RS00165	COG0070	glutamate synthase
H7A87_RS00165	COG0067	glutamate synthase
H7A87_RS00180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7A87_RS00190	COG1741	Belongs to the pirin family
H7A87_RS00195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7A87_RS00210	COG3459	Glycosyltransferase 36 associated
H7A87_RS00225	COG1205	dead DEAH box helicase
H7A87_RS00225	COG1111	helicase
H7A87_RS00230	COG1272	protein, Hemolysin III
H7A87_RS00265	COG3590	peptidase
H7A87_RS00275	COG0583	DNA-binding transcription factor activity
H7A87_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS00290	COG2814	Major facilitator Superfamily
H7A87_RS00355	COG1733	regulation of RNA biosynthetic process
H7A87_RS00360	COG3237	CsbD-like
H7A87_RS00395	COG0657	acetylesterase activity
H7A87_RS00405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7A87_RS00450	COG0714	Associated with various cellular activities
H7A87_RS00475	COG0596	Alpha beta hydrolase
H7A87_RS00510	COG4772	TonB-dependent receptor
H7A87_RS00520	COG0662	Cupin 2, conserved barrel domain protein
H7A87_RS00530	COG3284	Transcriptional regulator
H7A87_RS00535	COG1012	belongs to the aldehyde dehydrogenase family
H7A87_RS00570	COG4585	Histidine kinase
H7A87_RS00575	COG2197	response regulator
H7A87_RS00595	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7A87_RS00680	COG1595	DNA-templated transcription, initiation
H7A87_RS00790	COG0366	Alpha amylase catalytic
H7A87_RS00795	COG0366	Alpha amylase catalytic
H7A87_RS00800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7A87_RS00835	COG2755	lipolytic protein G-D-S-L family
H7A87_RS00845	COG0657	acetylesterase activity
H7A87_RS00845	COG2755	lipolytic protein G-D-S-L family
H7A87_RS00855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7A87_RS00870	COG3507	Belongs to the glycosyl hydrolase 43 family
H7A87_RS00875	COG1609	Transcriptional regulator
H7A87_RS00880	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H7A87_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS00900	COG2755	lipolytic protein G-D-S-L family
H7A87_RS00910	COG3186	Phenylalanine-4-hydroxylase
H7A87_RS00915	COG1522	sequence-specific DNA binding
H7A87_RS00925	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7A87_RS00935	COG1119	ATPase activity
H7A87_RS00950	COG0517	IMP dehydrogenase activity
H7A87_RS00950	COG1125	glycine betaine transport
H7A87_RS00965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7A87_RS00970	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7A87_RS01000	COG0489	protein tyrosine kinase activity
H7A87_RS01005	COG2062	phosphohistidine phosphatase, SixA
H7A87_RS01010	COG2353	YceI-like domain
H7A87_RS01015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7A87_RS01040	COG1881	PFAM PEBP family protein
H7A87_RS01055	COG0174	glutamine synthetase
H7A87_RS01060	COG0347	Belongs to the P(II) protein family
H7A87_RS01065	COG0004	ammonium transporteR
H7A87_RS01070	COG3852	Histidine kinase
H7A87_RS01075	COG2204	response regulator
H7A87_RS01080	COG2032	superoxide dismutase activity
H7A87_RS01085	COG2032	superoxide dismutase activity
H7A87_RS01090	COG0346	lactoylglutathione lyase activity
H7A87_RS01100	COG0183	Belongs to the thiolase family
H7A87_RS01140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7A87_RS01150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7A87_RS01160	COG0028	Belongs to the TPP enzyme family
H7A87_RS01165	COG2205	protein histidine kinase activity
H7A87_RS01190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7A87_RS01205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7A87_RS01210	COG3177	Filamentation induced by cAMP protein fic
H7A87_RS01215	COG0596	Alpha beta hydrolase
H7A87_RS01220	COG0727	PFAM Uncharacterised protein family (UPF0153)
H7A87_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
H7A87_RS01230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7A87_RS01260	COG4122	O-methyltransferase activity
H7A87_RS01265	COG0564	pseudouridine synthase activity
H7A87_RS01285	COG1446	asparaginase
H7A87_RS01290	COG0339	signal peptide processing
H7A87_RS01295	COG0681	Belongs to the peptidase S26 family
H7A87_RS01310	COG0475	glutathione-regulated potassium exporter activity
H7A87_RS01315	COG0583	DNA-binding transcription factor activity
H7A87_RS01320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7A87_RS01325	COG2224	Isocitrate lyase
H7A87_RS01355	COG4770	biotin carboxylase activity
H7A87_RS01360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7A87_RS01365	COG1960	acyl-CoA dehydrogenase activity
H7A87_RS01420	COG0523	cobalamin synthesis protein
H7A87_RS01430	COG0697	spore germination
H7A87_RS01440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7A87_RS01450	COG1846	Transcriptional regulator
H7A87_RS01455	COG1764	response to oxidative stress
H7A87_RS01480	COG0656	L-ascorbic acid biosynthetic process
H7A87_RS01485	COG2130	NADP-dependent
H7A87_RS01490	COG0667	Aldo Keto reductase
H7A87_RS01500	COG1187	pseudouridine synthase activity
H7A87_RS01510	COG1643	Atp-dependent helicase
H7A87_RS01515	COG0840	transmembrane signaling receptor activity
H7A87_RS01520	COG4807	Protein conserved in bacteria
H7A87_RS01525	COG2351	hydroxyisourate hydrolase activity
H7A87_RS01530	COG2072	flavoprotein involved in K transport
H7A87_RS01550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7A87_RS01585	COG1957	nucleoside hydrolase
H7A87_RS01610	COG0084	hydrolase, TatD family'
H7A87_RS01620	COG0583	DNA-binding transcription factor activity
H7A87_RS01625	COG2814	Major facilitator Superfamily
H7A87_RS01645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7A87_RS01650	COG1902	pentaerythritol trinitrate reductase activity
H7A87_RS01670	COG2223	nitrite transmembrane transporter activity
H7A87_RS01680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7A87_RS01685	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7A87_RS01690	COG0583	DNA-binding transcription factor activity
H7A87_RS01715	COG0702	epimerase
H7A87_RS01720	COG1733	regulation of RNA biosynthetic process
H7A87_RS01730	COG0840	transmembrane signaling receptor activity
H7A87_RS01810	COG0129	dihydroxy-acid dehydratase activity
H7A87_RS01825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7A87_RS01830	COG2814	Major facilitator Superfamily
H7A87_RS01875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7A87_RS01880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7A87_RS01910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7A87_RS01915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7A87_RS01925	COG3485	protocatechuate 3,4-dioxygenase
H7A87_RS01940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7A87_RS01945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7A87_RS01955	COG1414	Transcriptional regulator
H7A87_RS01965	COG0657	acetylesterase activity
H7A87_RS01975	COG0445	tRNA wobble uridine modification
H7A87_RS01985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7A87_RS02025	COG0156	8-amino-7-oxononanoate synthase activity
H7A87_RS02030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7A87_RS02035	COG1040	competence protein
H7A87_RS02040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7A87_RS02075	COG3264	Mechanosensitive ion channel
H7A87_RS02075	COG1511	domain protein
H7A87_RS02085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7A87_RS02090	COG2354	Protein conserved in bacteria
H7A87_RS02100	COG0297	glycogen (starch) synthase activity
H7A87_RS02105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7A87_RS02110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7A87_RS02135	COG0702	epimerase
H7A87_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS02175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7A87_RS02185	COG4221	oxidoreductase activity
H7A87_RS02200	COG0513	Belongs to the DEAD box helicase family
H7A87_RS02205	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7A87_RS02220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7A87_RS02235	COG3104	oligopeptide transport
H7A87_RS02255	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7A87_RS02265	COG1320	monovalent cation:proton antiporter activity
H7A87_RS02270	COG2212	antiporter activity
H7A87_RS02280	COG0651	ATP synthesis coupled electron transport
H7A87_RS02285	COG1006	Multisubunit Na H antiporter MnhC subunit
H7A87_RS02290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7A87_RS02290	COG2111	Na H antiporter
H7A87_RS02310	COG3179	chitinase
H7A87_RS02335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7A87_RS02355	COG1597	lipid kinase activity
H7A87_RS02385	COG0840	transmembrane signaling receptor activity
H7A87_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS02395	COG1063	alcohol dehydrogenase
H7A87_RS02400	COG1252	NADH dehydrogenase
H7A87_RS02420	COG0840	transmembrane signaling receptor activity
H7A87_RS02425	COG2207	Transcriptional regulator
H7A87_RS02465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7A87_RS02470	COG0134	indole-3-glycerol-phosphate synthase activity
H7A87_RS02480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7A87_RS02495	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H7A87_RS02505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7A87_RS02520	COG1051	belongs to the nudix hydrolase family
H7A87_RS02560	COG0316	Belongs to the HesB IscA family
H7A87_RS02575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H7A87_RS02600	COG2814	Major facilitator Superfamily
H7A87_RS02605	COG1289	transmembrane transporter activity
H7A87_RS02610	COG0151	Belongs to the GarS family
H7A87_RS02615	COG0138	bifunctional purine biosynthesis protein purh
H7A87_RS02630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7A87_RS02650	COG2264	protein methyltransferase activity
H7A87_RS02665	COG0439	Biotin carboxylase
H7A87_RS02675	COG0511	ligase activity, forming carbon-carbon bonds
H7A87_RS02680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7A87_RS02690	COG1324	tolerance protein
H7A87_RS02695	COG2356	endonuclease I
H7A87_RS02715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7A87_RS02740	COG3712	iron ion homeostasis
H7A87_RS02765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7A87_RS02795	COG2353	YceI-like domain
H7A87_RS02800	COG2375	cellular response to nickel ion
H7A87_RS02815	COG3052	prosthetic group binding
H7A87_RS02850	COG1802	Transcriptional regulator
H7A87_RS02855	COG0546	phosphoglycolate phosphatase activity
H7A87_RS02960	COG1595	DNA-templated transcription, initiation
H7A87_RS02975	COG4206	TonB-dependent receptor
H7A87_RS02980	COG1506	peptidase
H7A87_RS02980	COG0823	Involved in the tonB-independent uptake of proteins
H7A87_RS03030	COG0435	Glutathione S-transferase
H7A87_RS03070	COG0823	Involved in the tonB-independent uptake of proteins
H7A87_RS03070	COG1506	peptidase
H7A87_RS03100	COG0697	spore germination
H7A87_RS03115	COG1113	amino acid transport
H7A87_RS03175	COG0840	transmembrane signaling receptor activity
H7A87_RS03180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7A87_RS03180	COG5297	Belongs to the glycosyl hydrolase family 6
H7A87_RS03185	COG0659	secondary active sulfate transmembrane transporter activity
H7A87_RS03200	COG2943	transferase activity, transferring hexosyl groups
H7A87_RS03210	COG3275	phosphorelay sensor kinase activity
H7A87_RS03220	COG0181	hydroxymethylbilane synthase activity
H7A87_RS03245	COG1505	serine-type exopeptidase activity
H7A87_RS03250	COG0436	Aminotransferase
H7A87_RS03260	COG2832	Protein of unknown function (DUF454)
H7A87_RS03270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7A87_RS03290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7A87_RS03295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7A87_RS03320	COG2226	methyltransferase
H7A87_RS03325	COG5001	Diguanylate cyclase
H7A87_RS03325	COG3300	MHYT domain
H7A87_RS03330	COG0308	aminopeptidase N
H7A87_RS03365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7A87_RS03375	COG3284	Transcriptional regulator
H7A87_RS03380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7A87_RS03385	COG1077	Cell shape determining protein MreB Mrl
H7A87_RS03390	COG1792	Involved in formation and maintenance of cell shape
H7A87_RS03405	COG0772	Belongs to the SEDS family
H7A87_RS03415	COG2951	lytic endotransglycosylase activity
H7A87_RS03420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7A87_RS03425	COG1686	Belongs to the peptidase S11 family
H7A87_RS03440	COG2921	Belongs to the UPF0250 family
H7A87_RS03445	COG0321	lipoyl(octanoyl) transferase activity
H7A87_RS03450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7A87_RS03465	COG0583	DNA-binding transcription factor activity
H7A87_RS03475	COG1056	cytidyltransferase-related domain
H7A87_RS03475	COG1051	belongs to the nudix hydrolase family
H7A87_RS03510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7A87_RS03515	COG0673	inositol 2-dehydrogenase activity
H7A87_RS03520	COG2823	Periplasmic or secreted lipoprotein
H7A87_RS03525	COG4251	negative regulation of phosphorylation
H7A87_RS03530	COG0784	Response regulator, receiver
H7A87_RS03535	COG4191	Histidine kinase
H7A87_RS03540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7A87_RS03545	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS03590	COG1459	type II secretion system
H7A87_RS03615	COG3156	type II secretion system protein K
H7A87_RS03640	COG3250	beta-galactosidase activity
H7A87_RS03655	COG2188	Transcriptional regulator
H7A87_RS03665	COG1609	Transcriptional regulator
H7A87_RS03670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7A87_RS03675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7A87_RS03705	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7A87_RS03715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7A87_RS03725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7A87_RS03740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7A87_RS03745	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7A87_RS03760	COG2205	protein histidine kinase activity
H7A87_RS03780	COG3920	Histidine kinase
H7A87_RS03795	COG3791	Glutathione-dependent formaldehyde-activating
H7A87_RS03800	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7A87_RS03805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7A87_RS03810	COG0697	spore germination
H7A87_RS03825	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7A87_RS03830	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7A87_RS03840	COG2205	protein histidine kinase activity
H7A87_RS03845	COG0745	RESPONSE REGULATOR receiver
H7A87_RS03850	COG0277	FAD linked oxidase domain protein
H7A87_RS03855	COG1988	membrane-bound metal-dependent
H7A87_RS03860	COG0792	nuclease activity
H7A87_RS03890	COG0275	rRNA processing
H7A87_RS03895	COG3116	cell division
H7A87_RS03905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7A87_RS03910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7A87_RS03930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7A87_RS03935	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7A87_RS03940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7A87_RS03950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7A87_RS03965	COG0739	heme binding
H7A87_RS03970	COG0653	protein targeting
H7A87_RS03980	COG0494	nUDIX hydrolase
H7A87_RS03995	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7A87_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS04005	COG3321	synthase
H7A87_RS04005	COG0604	alcohol dehydrogenase
H7A87_RS04025	COG0366	Alpha amylase catalytic
H7A87_RS04050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7A87_RS04075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7A87_RS04090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7A87_RS04095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7A87_RS04105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7A87_RS04110	COG0667	Aldo Keto reductase
H7A87_RS04120	COG4771	TonB-dependent receptor
H7A87_RS04140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7A87_RS04145	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7A87_RS04155	COG2175	clavaminate synthase activity
H7A87_RS04165	COG4181	ATPase activity
H7A87_RS04180	COG0642	Histidine kinase
H7A87_RS04190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7A87_RS04210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7A87_RS04225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7A87_RS04230	COG2967	ApaG domain
H7A87_RS04235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7A87_RS04240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7A87_RS04250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7A87_RS04255	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7A87_RS04260	COG2096	Adenosyltransferase
H7A87_RS04270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7A87_RS04275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7A87_RS04305	COG3384	dioxygenase
H7A87_RS04310	COG0583	DNA-binding transcription factor activity
H7A87_RS04315	COG0318	PFAM AMP-dependent synthetase and ligase
H7A87_RS04325	COG1024	Enoyl-CoA hydratase
H7A87_RS04345	COG3386	PFAM SMP-30 Gluconolaconase
H7A87_RS04375	COG0697	spore germination
H7A87_RS04380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7A87_RS04400	COG5002	protein histidine kinase activity
H7A87_RS04400	COG0784	Response regulator, receiver
H7A87_RS04400	COG2205	protein histidine kinase activity
H7A87_RS04405	COG2197	response regulator
H7A87_RS04415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7A87_RS04425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7A87_RS04430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7A87_RS04435	COG0583	DNA-binding transcription factor activity
H7A87_RS04440	COG3634	alkyl hydroperoxide reductase activity
H7A87_RS04450	COG2890	protein-(glutamine-N5) methyltransferase activity
H7A87_RS04470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7A87_RS04470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7A87_RS04500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7A87_RS04540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7A87_RS04545	COG1404	Belongs to the peptidase S8 family
H7A87_RS04550	COG1404	Belongs to the peptidase S8 family
H7A87_RS04555	COG1404	Belongs to the peptidase S8 family
H7A87_RS04580	COG1295	ribonuclease BN
H7A87_RS04585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7A87_RS04590	COG1254	Belongs to the acylphosphatase family
H7A87_RS04605	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7A87_RS04615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7A87_RS04620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7A87_RS04630	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7A87_RS04645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7A87_RS04650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7A87_RS04655	COG0193	aminoacyl-tRNA hydrolase activity
H7A87_RS04660	COG0012	GTP binding
H7A87_RS04680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7A87_RS04690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7A87_RS04695	COG0250	Participates in transcription elongation, termination and antitermination
H7A87_RS04700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7A87_RS04705	COG0081	regulation of translation
H7A87_RS04710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7A87_RS04715	COG0222	ribosome binding
H7A87_RS04725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7A87_RS04730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7A87_RS04740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7A87_RS04745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7A87_RS04750	COG0051	transcription antitermination factor activity, RNA binding
H7A87_RS04770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7A87_RS04780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7A87_RS04795	COG0255	Belongs to the universal ribosomal protein uL29 family
H7A87_RS04810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7A87_RS04845	COG1841	ribosomal large subunit assembly
H7A87_RS04855	COG0201	protein transport
H7A87_RS04880	COG0203	ribosomal protein L17
H7A87_RS04890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7A87_RS04900	COG0154	amidase activity
H7A87_RS04910	COG1217	gtp-binding protein TYPA
H7A87_RS04915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7A87_RS04925	COG0625	glutathione transferase activity
H7A87_RS04940	COG1902	pentaerythritol trinitrate reductase activity
H7A87_RS04940	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7A87_RS04950	COG2885	chlorophyll binding
H7A87_RS04975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7A87_RS04980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7A87_RS04985	COG4208	sulfate ABC transporter
H7A87_RS04990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7A87_RS05000	COG1063	alcohol dehydrogenase
H7A87_RS05015	COG0406	alpha-ribazole phosphatase activity
H7A87_RS05025	COG0285	dihydrofolate synthase activity
H7A87_RS05045	COG2833	Protein of unknown function (DUF455)
H7A87_RS05050	COG3291	Pkd domain containing protein
H7A87_RS05060	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7A87_RS05065	COG0671	phosphoesterase, PA-phosphatase related
H7A87_RS05070	COG0438	transferase activity, transferring glycosyl groups
H7A87_RS05080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7A87_RS05095	COG4783	chaperone-mediated protein folding
H7A87_RS05110	COG0473	3-isopropylmalate dehydrogenase activity
H7A87_RS05145	COG3852	Histidine kinase
H7A87_RS05155	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7A87_RS05165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7A87_RS05195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7A87_RS05205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7A87_RS05215	COG0328	RNA-DNA hybrid ribonuclease activity
H7A87_RS05225	COG0631	protein serine/threonine phosphatase activity
H7A87_RS05240	COG0859	PFAM glycosyl transferase family 9
H7A87_RS05250	COG1234	tRNA 3'-trailer cleavage
H7A87_RS05255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7A87_RS05260	COG0315	cyclic pyranopterin monophosphate synthase activity
H7A87_RS05265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7A87_RS05270	COG0314	molybdopterin synthase activity
H7A87_RS05370	COG0583	DNA-binding transcription factor activity
H7A87_RS05430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7A87_RS05435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7A87_RS05440	COG0537	adenosine 5'-monophosphoramidase activity
H7A87_RS05460	COG0714	Associated with various cellular activities
H7A87_RS05480	COG0424	maF-like protein
H7A87_RS05485	COG1399	metal-binding, possibly nucleic acid-binding protein
H7A87_RS05490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7A87_RS05495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7A87_RS05505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7A87_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS05525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7A87_RS05530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7A87_RS05555	COG3829	transcription factor binding
H7A87_RS05580	COG3609	addiction module antidote protein, CC2985 family
H7A87_RS05605	COG2373	Large extracellular alpha-helical protein
H7A87_RS05625	COG4953	penicillin-binding protein 1C
H7A87_RS05635	COG0678	peroxiredoxin activity
H7A87_RS05655	COG0330	HflC and HflK could
H7A87_RS05660	COG0330	HflC and HflK could
H7A87_RS05675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7A87_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS05695	COG1309	transcriptional regulator
H7A87_RS05755	COG1309	transcriptional regulator
H7A87_RS05765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7A87_RS05775	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS05785	COG3537	Alpha-1,2-mannosidase
H7A87_RS05820	COG2323	membrane
H7A87_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS05835	COG2271	Major facilitator Superfamily
H7A87_RS05860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7A87_RS05865	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7A87_RS05870	COG2080	2 iron, 2 sulfur cluster binding
H7A87_RS05915	COG0587	DNA-directed DNA polymerase activity
H7A87_RS05920	COG1297	OPT oligopeptide transporter protein
H7A87_RS05940	COG1506	peptidase
H7A87_RS05940	COG0823	Involved in the tonB-independent uptake of proteins
H7A87_RS05955	COG2207	Transcriptional regulator
H7A87_RS05955	COG1917	Cupin 2, conserved barrel domain protein
H7A87_RS05960	COG0753	catalase activity
H7A87_RS05965	COG0656	L-ascorbic acid biosynthetic process
H7A87_RS05975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7A87_RS05975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7A87_RS05980	COG2814	Major facilitator Superfamily
H7A87_RS06000	COG2194	sulfuric ester hydrolase activity
H7A87_RS06010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7A87_RS06015	COG0745	RESPONSE REGULATOR receiver
H7A87_RS06020	COG5002	protein histidine kinase activity
H7A87_RS06035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7A87_RS06040	COG2894	cell division
H7A87_RS06045	COG0850	regulation of cytokinetic process
H7A87_RS06055	COG4585	Histidine kinase
H7A87_RS06060	COG2197	response regulator
H7A87_RS06075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H7A87_RS06115	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7A87_RS06125	COG1595	DNA-templated transcription, initiation
H7A87_RS06135	COG1946	Acyl-CoA thioesterase
H7A87_RS06140	COG1024	Enoyl-CoA hydratase
H7A87_RS06150	COG0824	Thioesterase
H7A87_RS06155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7A87_RS06165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7A87_RS06170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7A87_RS06180	COG0728	peptidoglycan biosynthetic process
H7A87_RS06185	COG0196	riboflavin kinase activity
H7A87_RS06195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7A87_RS06200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7A87_RS06215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7A87_RS06220	COG1845	cytochrome c oxidase, subunit III
H7A87_RS06225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7A87_RS06240	COG3152	Membrane
H7A87_RS06250	COG2207	Transcriptional regulator
H7A87_RS06255	COG0326	Molecular chaperone. Has ATPase activity
H7A87_RS06265	COG1366	Belongs to the anti-sigma-factor antagonist family
H7A87_RS06270	COG1366	Belongs to the anti-sigma-factor antagonist family
H7A87_RS06275	COG2172	sigma factor antagonist activity
H7A87_RS06295	COG4771	TonB-dependent receptor
H7A87_RS06305	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7A87_RS06310	COG2205	protein histidine kinase activity
H7A87_RS06320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7A87_RS06325	COG3437	response regulator, receiver
H7A87_RS06325	COG4999	Histidine kinase
H7A87_RS06325	COG2205	protein histidine kinase activity
H7A87_RS06325	COG3850	Histidine kinase
H7A87_RS06330	COG0784	Response regulator, receiver
H7A87_RS06330	COG4191	Histidine kinase
H7A87_RS06355	COG3534	alpha-L-arabinofuranosidase
H7A87_RS06365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7A87_RS06370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7A87_RS06375	COG2070	2-Nitropropane dioxygenase
H7A87_RS06395	COG0336	Belongs to the RNA methyltransferase TrmD family
H7A87_RS06405	COG0534	Mate efflux family protein
H7A87_RS06415	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7A87_RS06565	COG0322	excinuclease ABC activity
H7A87_RS06590	COG1309	transcriptional regulator
H7A87_RS06615	COG3279	Response regulator of the LytR AlgR family
H7A87_RS06625	COG0583	DNA-binding transcription factor activity
H7A87_RS06630	COG0028	Belongs to the TPP enzyme family
H7A87_RS06645	COG3250	beta-galactosidase activity
H7A87_RS06650	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H7A87_RS06660	COG3800	Transcriptional regulator
H7A87_RS06660	COG1396	sequence-specific DNA binding
H7A87_RS06670	COG1960	acyl-CoA dehydrogenase activity
H7A87_RS06710	COG0457	Tetratricopeptide repeat
H7A87_RS06720	COG1024	Enoyl-CoA hydratase
H7A87_RS06720	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7A87_RS06735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7A87_RS06740	COG0481	GTPase activity
H7A87_RS06765	COG1381	Involved in DNA repair and RecF pathway recombination
H7A87_RS06770	COG0745	RESPONSE REGULATOR receiver
H7A87_RS06780	COG2954	triphosphatase activity
H7A87_RS06785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7A87_RS06790	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H7A87_RS06795	COG3046	protein related to deoxyribodipyrimidine photolyase
H7A87_RS06800	COG1472	Belongs to the glycosyl hydrolase 3 family
H7A87_RS06805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7A87_RS06810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7A87_RS06815	COG1278	Cold shock
H7A87_RS06820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7A87_RS06830	COG1201	RNA secondary structure unwinding
H7A87_RS06835	COG1793	dna ligase
H7A87_RS06845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7A87_RS06845	COG1793	dna ligase
H7A87_RS06880	COG0183	Belongs to the thiolase family
H7A87_RS06900	COG1451	nucleotide metabolic process
H7A87_RS06905	COG5487	UPF0391 membrane protein
H7A87_RS06915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7A87_RS06935	COG1047	Peptidyl-prolyl cis-trans
H7A87_RS06945	COG2824	Alkylphosphonate utilization operon protein PhnA
H7A87_RS06965	COG1902	pentaerythritol trinitrate reductase activity
H7A87_RS06970	COG2814	Major facilitator Superfamily
H7A87_RS07000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7A87_RS07000	COG0392	lysyltransferase activity
H7A87_RS07010	COG0251	oxidation-reduction process
H7A87_RS07015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7A87_RS07030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7A87_RS07055	COG1595	DNA-templated transcription, initiation
H7A87_RS07070	COG2878	Part of a membrane complex involved in electron transport
H7A87_RS07080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7A87_RS07080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7A87_RS07095	COG1131	(ABC) transporter
H7A87_RS07100	COG0346	lactoylglutathione lyase activity
H7A87_RS07105	COG0833	amino acid
H7A87_RS07110	COG2040	homocysteine
H7A87_RS07130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7A87_RS07160	COG1981	membrane
H7A87_RS07180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7A87_RS07185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7A87_RS07195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7A87_RS07210	COG0750	zinc metalloprotease
H7A87_RS07215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7A87_RS07220	COG0575	Belongs to the CDS family
H7A87_RS07230	COG0233	cytoplasmic translational termination
H7A87_RS07235	COG0528	UMP kinase activity
H7A87_RS07245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7A87_RS07250	COG0052	Belongs to the universal ribosomal protein uS2 family
H7A87_RS07305	COG1393	Belongs to the ArsC family
H7A87_RS07310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7A87_RS07315	COG0367	asparagine synthase
H7A87_RS07325	COG4774	siderophore transport
H7A87_RS07365	COG1566	PFAM secretion protein HlyD family protein
H7A87_RS07370	COG2814	Major facilitator Superfamily
H7A87_RS07430	COG0339	signal peptide processing
H7A87_RS07435	COG0386	Belongs to the glutathione peroxidase family
H7A87_RS07465	COG0288	reversible hydration of carbon dioxide
H7A87_RS07475	COG2839	Protein conserved in bacteria
H7A87_RS07495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7A87_RS07500	COG0084	hydrolase, TatD family'
H7A87_RS07515	COG1960	acyl-CoA dehydrogenase activity
H7A87_RS07530	COG0367	asparagine synthase
H7A87_RS07540	COG0305	Participates in initiation and elongation during chromosome replication
H7A87_RS07545	COG0415	Belongs to the DNA photolyase family
H7A87_RS07555	COG0583	DNA-binding transcription factor activity
H7A87_RS07570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7A87_RS07600	COG3706	GGDEF domain
H7A87_RS07725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7A87_RS07740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7A87_RS07750	COG0497	DNA recombination
H7A87_RS07755	COG1420	regulation of RNA biosynthetic process
H7A87_RS07760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7A87_RS07765	COG0443	Heat shock 70 kDa protein
H7A87_RS07770	COG0484	heat shock protein binding
H7A87_RS07775	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7A87_RS07805	COG0583	DNA-binding transcription factor activity
H7A87_RS07810	COG1132	(ABC) transporter
H7A87_RS07845	COG2850	peptidyl-arginine hydroxylation
H7A87_RS07855	COG1253	flavin adenine dinucleotide binding
H7A87_RS07885	COG1131	(ABC) transporter
H7A87_RS07890	COG1725	Transcriptional regulator
H7A87_RS07900	COG0386	Belongs to the glutathione peroxidase family
H7A87_RS07915	COG2900	Belongs to the SlyX family
H7A87_RS07930	COG1609	Transcriptional regulator
H7A87_RS07940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7A87_RS07950	COG1410	methionine synthase
H7A87_RS07950	COG0646	methionine synthase
H7A87_RS07955	COG0646	methionine synthase
H7A87_RS07955	COG1410	methionine synthase
H7A87_RS07960	COG2226	methyltransferase
H7A87_RS07965	COG1960	acyl-CoA dehydrogenase activity
H7A87_RS07970	COG1960	acyl-CoA dehydrogenase activity
H7A87_RS07985	COG0557	exoribonuclease II activity
H7A87_RS07995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7A87_RS08010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7A87_RS08020	COG0704	Plays a role in the regulation of phosphate uptake
H7A87_RS08025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7A87_RS08030	COG0581	inorganic phosphate transmembrane transporter activity
H7A87_RS08035	COG0573	inorganic phosphate transmembrane transporter activity
H7A87_RS08040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7A87_RS08065	COG0659	secondary active sulfate transmembrane transporter activity
H7A87_RS08070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7A87_RS08080	COG1024	Enoyl-CoA hydratase
H7A87_RS08090	COG0494	nUDIX hydrolase
H7A87_RS08125	COG0488	(ABC) transporter
H7A87_RS08135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7A87_RS08160	COG2925	Exonuclease
H7A87_RS08165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7A87_RS08170	COG3844	kynureninase activity
H7A87_RS08180	COG0662	Cupin 2, conserved barrel domain protein
H7A87_RS08185	COG0288	reversible hydration of carbon dioxide
H7A87_RS08190	COG2808	Putative FMN-binding domain
H7A87_RS08205	COG0017	Asparaginyl-tRNA synthetase
H7A87_RS08210	COG0316	Belongs to the HesB IscA family
H7A87_RS08235	COG3115	cell septum assembly
H7A87_RS08240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7A87_RS08245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7A87_RS08250	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H7A87_RS08260	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7A87_RS08270	COG4993	Dehydrogenase
H7A87_RS08285	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7A87_RS08295	COG2986	histidine ammonia-lyase
H7A87_RS08300	COG1228	amidohydrolase
H7A87_RS08335	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H7A87_RS08340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7A87_RS08345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7A87_RS08350	COG0077	Prephenate dehydratase
H7A87_RS08350	COG1605	Chorismate mutase
H7A87_RS08355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7A87_RS08370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7A87_RS08375	COG0583	DNA-binding transcription factor activity
H7A87_RS08460	COG3459	Glycosyltransferase 36 associated
H7A87_RS08525	COG3685	Protein conserved in bacteria
H7A87_RS08555	COG0840	transmembrane signaling receptor activity
H7A87_RS08585	COG0840	transmembrane signaling receptor activity
H7A87_RS08605	COG4191	Histidine kinase
H7A87_RS08605	COG0784	Response regulator, receiver
H7A87_RS08610	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H7A87_RS08615	COG4191	Histidine kinase
H7A87_RS08615	COG0784	Response regulator, receiver
H7A87_RS08630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7A87_RS08655	COG1404	Belongs to the peptidase S8 family
H7A87_RS08665	COG1595	DNA-templated transcription, initiation
H7A87_RS08715	COG2244	polysaccharide biosynthetic process
H7A87_RS08735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7A87_RS08745	COG2226	methyltransferase
H7A87_RS08755	COG0438	transferase activity, transferring glycosyl groups
H7A87_RS08775	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H7A87_RS08780	COG1132	(ABC) transporter
H7A87_RS08785	COG0477	Major facilitator Superfamily
H7A87_RS08790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7A87_RS08805	COG1253	flavin adenine dinucleotide binding
H7A87_RS08840	COG0504	CTP synthase activity
H7A87_RS08845	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7A87_RS08850	COG0148	phosphopyruvate hydratase activity
H7A87_RS08860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7A87_RS08865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7A87_RS08875	COG2840	Smr protein MutS2
H7A87_RS08880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7A87_RS08885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7A87_RS08890	COG1238	metal cluster binding
H7A87_RS08905	COG1534	Rna-binding protein
H7A87_RS08920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7A87_RS08925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7A87_RS08935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7A87_RS08940	COG1546	Belongs to the CinA family
H7A87_RS08945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7A87_RS08955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7A87_RS08960	COG2137	regulation of response to DNA damage stimulus
H7A87_RS08965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7A87_RS08970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7A87_RS08985	COG1741	Belongs to the pirin family
H7A87_RS08990	COG0583	DNA-binding transcription factor activity
H7A87_RS09015	COG0352	thiamine-phosphate diphosphorylase activity
H7A87_RS09015	COG0351	phosphomethylpyrimidine kinase
H7A87_RS09030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7A87_RS09035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7A87_RS09050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7A87_RS09060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7A87_RS09065	COG3734	2-keto-3-deoxy-galactonokinase
H7A87_RS09075	COG4948	Mandelate Racemase Muconate Lactonizing
H7A87_RS09080	COG0800	Aldolase
H7A87_RS09115	COG1501	Belongs to the glycosyl hydrolase 31 family
H7A87_RS09125	COG1070	Carbohydrate kinase
H7A87_RS09130	COG2115	Belongs to the xylose isomerase family
H7A87_RS09135	COG0477	Major facilitator Superfamily
H7A87_RS09155	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7A87_RS09180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7A87_RS09185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7A87_RS09215	COG1472	Belongs to the glycosyl hydrolase 3 family
H7A87_RS09225	COG2203	Gaf domain
H7A87_RS09225	COG5001	Diguanylate cyclase
H7A87_RS09225	COG3706	GGDEF domain
H7A87_RS09225	COG4251	negative regulation of phosphorylation
H7A87_RS09230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7A87_RS09235	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7A87_RS09245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7A87_RS09250	COG0671	phosphoesterase, PA-phosphatase related
H7A87_RS09260	COG1794	racemase activity, acting on amino acids and derivatives
H7A87_RS09265	COG0697	spore germination
H7A87_RS09270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7A87_RS09290	COG1012	belongs to the aldehyde dehydrogenase family
H7A87_RS09315	COG1215	transferase activity, transferring glycosyl groups
H7A87_RS09320	COG1649	PFAM Uncharacterised BCR, COG1649
H7A87_RS09320	COG0726	polysaccharide deacetylase
H7A87_RS09330	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H7A87_RS09340	COG0460	homoserine dehydrogenase
H7A87_RS09340	COG0527	aspartate kinase activity
H7A87_RS09365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7A87_RS09370	COG0124	histidyl-tRNA synthetase
H7A87_RS09380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7A87_RS09390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7A87_RS09395	COG0131	Imidazoleglycerol-phosphate dehydratase
H7A87_RS09395	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7A87_RS09400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7A87_RS09405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7A87_RS09415	COG0140	phosphoribosyl-ATP diphosphatase activity
H7A87_RS09415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7A87_RS09435	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7A87_RS09445	COG0531	amino acid
H7A87_RS09450	COG0531	amino acid
H7A87_RS09460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7A87_RS09465	COG0277	FAD linked oxidase domain protein
H7A87_RS09485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7A87_RS09525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7A87_RS09530	COG2258	MOSC domain
H7A87_RS09540	COG0505	Belongs to the CarA family
H7A87_RS09550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7A87_RS09555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7A87_RS09565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7A87_RS09595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7A87_RS09605	COG0784	Response regulator, receiver
H7A87_RS09605	COG2198	Histidine kinase
H7A87_RS09605	COG2205	protein histidine kinase activity
H7A87_RS09610	COG1024	Enoyl-CoA hydratase
H7A87_RS09615	COG0318	PFAM AMP-dependent synthetase and ligase
H7A87_RS09645	COG2267	carboxylic ester hydrolase activity
H7A87_RS09670	COG0840	transmembrane signaling receptor activity
H7A87_RS09680	COG0835	chemotaxis
H7A87_RS09690	COG0840	transmembrane signaling receptor activity
H7A87_RS09695	COG0840	transmembrane signaling receptor activity
H7A87_RS09710	COG0840	transmembrane signaling receptor activity
H7A87_RS09720	COG0840	transmembrane signaling receptor activity
H7A87_RS09745	COG0745	RESPONSE REGULATOR receiver
H7A87_RS09755	COG0835	chemotaxis
H7A87_RS09765	COG1360	Flagellar Motor Protein
H7A87_RS09770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7A87_RS09820	COG2198	Histidine kinase
H7A87_RS09820	COG0784	Response regulator, receiver
H7A87_RS09820	COG0643	Histidine kinase
H7A87_RS09875	COG1684	flagellar biosynthetic protein fliR
H7A87_RS09890	COG3190	flagellar
H7A87_RS09940	COG1677	Flagellar hook-basal body complex protein FliE
H7A87_RS09955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7A87_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS09995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7A87_RS10015	COG2201	protein-glutamate methylesterase activity
H7A87_RS10045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7A87_RS10050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7A87_RS10065	COG3951	Flagellar rod assembly protein muramidase FlgJ
H7A87_RS10065	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7A87_RS10070	COG1706	bacterial-type flagellum-dependent cell motility
H7A87_RS10085	COG4787	bacterial-type flagellum-dependent cell motility
H7A87_RS10095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7A87_RS10100	COG1558	bacterial-type flagellum-dependent cell motility
H7A87_RS10110	COG0835	chemotaxis
H7A87_RS10110	COG0784	Response regulator, receiver
H7A87_RS10130	COG4191	Histidine kinase
H7A87_RS10160	COG2915	High frequency lysogenization protein hflD homolog
H7A87_RS10165	COG0482	sulfurtransferase activity
H7A87_RS10185	COG0542	response to heat
H7A87_RS10195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7A87_RS10205	COG0492	ferredoxin-NADP+ reductase activity
H7A87_RS10210	COG1674	ftsk spoiiie
H7A87_RS10225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7A87_RS10230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7A87_RS10235	COG0183	Belongs to the thiolase family
H7A87_RS10240	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7A87_RS10240	COG1024	Enoyl-CoA hydratase
H7A87_RS10255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7A87_RS10265	COG1426	Protein conserved in bacteria
H7A87_RS10275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7A87_RS10280	COG1160	GTP binding
H7A87_RS10285	COG0303	'Molybdopterin
H7A87_RS10290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7A87_RS10305	COG0708	Exodeoxyribonuclease III
H7A87_RS10315	COG0303	'Molybdopterin
H7A87_RS10320	COG0746	molybdenum cofactor guanylyltransferase activity
H7A87_RS10330	COG1648	precorrin-2 dehydrogenase activity
H7A87_RS10330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7A87_RS10340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7A87_RS10345	COG2223	nitrite transmembrane transporter activity
H7A87_RS10350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7A87_RS10360	COG0243	molybdopterin cofactor binding
H7A87_RS10380	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7A87_RS10390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7A87_RS10400	COG0579	oxidoreductase
H7A87_RS10420	COG5001	Diguanylate cyclase
H7A87_RS10465	COG4191	Histidine kinase
H7A87_RS10465	COG0784	Response regulator, receiver
H7A87_RS10505	COG0840	transmembrane signaling receptor activity
H7A87_RS10510	COG0583	DNA-binding transcription factor activity
H7A87_RS10560	COG3781	membrane
H7A87_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS10610	COG0428	transporter
H7A87_RS10615	COG0564	pseudouridine synthase activity
H7A87_RS10620	COG1530	ribonuclease E activity
H7A87_RS10630	COG1054	Belongs to the UPF0176 family
H7A87_RS10650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H7A87_RS10675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7A87_RS10680	COG0322	excinuclease ABC activity
H7A87_RS10690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7A87_RS10695	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7A87_RS10700	COG1663	tetraacyldisaccharide 4'-kinase activity
H7A87_RS10705	COG1132	(ABC) transporter
H7A87_RS10710	COG0848	biopolymer transport protein
H7A87_RS10715	COG0811	peptide transport
H7A87_RS10730	COG1136	(ABC) transporter
H7A87_RS10735	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7A87_RS10745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7A87_RS10750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7A87_RS10765	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7A87_RS10790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7A87_RS10795	COG0837	glucose binding
H7A87_RS10805	COG0129	dihydroxy-acid dehydratase activity
H7A87_RS10810	COG0800	Aldolase
H7A87_RS10880	COG5002	protein histidine kinase activity
H7A87_RS10880	COG0784	Response regulator, receiver
H7A87_RS10880	COG2205	protein histidine kinase activity
H7A87_RS10885	COG2183	response to ionizing radiation
H7A87_RS10910	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7A87_RS10920	COG1183	phosphatidylcholine synthase activity
H7A87_RS10925	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS10950	COG0668	transmembrane transport
H7A87_RS10955	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7A87_RS10970	COG1914	H( )-stimulated, divalent metal cation uptake system
H7A87_RS11010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7A87_RS11020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7A87_RS11025	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7A87_RS11040	COG0539	negative regulation of cytoplasmic translation
H7A87_RS11045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7A87_RS11060	COG2957	Belongs to the agmatine deiminase family
H7A87_RS11065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7A87_RS11090	COG0395	ABC-type sugar transport system, permease component
H7A87_RS11095	COG1175	transmembrane transport
H7A87_RS11125	COG2350	Protein conserved in bacteria
H7A87_RS11130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7A87_RS11135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7A87_RS11140	COG1187	pseudouridine synthase activity
H7A87_RS11160	COG0436	Aminotransferase
H7A87_RS11165	COG4133	protoheme IX ABC transporter activity
H7A87_RS11185	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7A87_RS11190	COG1138	Cytochrome C-type biogenesis protein
H7A87_RS11210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7A87_RS11225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7A87_RS11230	COG4988	ABC transporter
H7A87_RS11240	COG1294	oxidase, subunit
H7A87_RS11295	COG0165	Argininosuccinate lyase
H7A87_RS11310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7A87_RS11315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7A87_RS11320	COG0137	argininosuccinate synthase activity
H7A87_RS11330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7A87_RS11340	COG0215	cysteine-tRNA ligase activity
H7A87_RS11345	COG2166	iron-sulfur cluster assembly
H7A87_RS11365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7A87_RS11385	COG4302	ethanolamine ammonia-lyase activity
H7A87_RS11440	COG0402	S-adenosylhomocysteine deaminase activity
H7A87_RS11450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7A87_RS11460	COG5001	Diguanylate cyclase
H7A87_RS11460	COG3300	MHYT domain
H7A87_RS11475	COG0483	inositol monophosphate 1-phosphatase activity
H7A87_RS11480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7A87_RS11495	COG0488	(ABC) transporter
H7A87_RS11500	COG0513	Belongs to the DEAD box helicase family
H7A87_RS11505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7A87_RS11510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7A87_RS11520	COG0625	glutathione transferase activity
H7A87_RS11540	COG2081	HI0933 family
H7A87_RS11555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7A87_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS11580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7A87_RS11585	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7A87_RS11595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7A87_RS11595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7A87_RS11600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7A87_RS11615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7A87_RS11640	COG2199	diguanylate cyclase activity
H7A87_RS11645	COG0835	chemotaxis
H7A87_RS11650	COG0840	transmembrane signaling receptor activity
H7A87_RS11655	COG2094	Belongs to the DNA glycosylase MPG family
H7A87_RS11660	COG1201	RNA secondary structure unwinding
H7A87_RS11670	COG2969	positive regulation of protein catabolic process
H7A87_RS11675	COG0625	glutathione transferase activity
H7A87_RS11680	COG2857	Cytochrome c1
H7A87_RS11685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7A87_RS11690	COG0723	plastoquinol--plastocyanin reductase activity
H7A87_RS11695	COG0741	lytic transglycosylase activity
H7A87_RS11710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7A87_RS11715	COG1702	phosphate starvation-inducible protein PhoH
H7A87_RS11720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7A87_RS11730	COG4535	Mg2 and Co2 transporter CorC
H7A87_RS11745	COG1012	belongs to the aldehyde dehydrogenase family
H7A87_RS11755	COG1177	transmembrane transport
H7A87_RS11760	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7A87_RS11765	COG3842	ATPase activity
H7A87_RS11785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7A87_RS11800	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7A87_RS11805	COG0174	glutamine synthetase
H7A87_RS11810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7A87_RS11820	COG0477	Major facilitator Superfamily
H7A87_RS11830	COG0243	molybdopterin cofactor binding
H7A87_RS11835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7A87_RS11840	COG2223	nitrite transmembrane transporter activity
H7A87_RS11845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7A87_RS11855	COG2733	membrane
H7A87_RS11860	COG5002	protein histidine kinase activity
H7A87_RS11860	COG2205	protein histidine kinase activity
H7A87_RS11860	COG0784	Response regulator, receiver
H7A87_RS11870	COG0477	Major facilitator Superfamily
H7A87_RS11880	COG1902	pentaerythritol trinitrate reductase activity
H7A87_RS11890	COG3321	synthase
H7A87_RS11890	COG0604	alcohol dehydrogenase
H7A87_RS11900	COG2902	Dehydrogenase
H7A87_RS11910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7A87_RS11915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7A87_RS11920	COG1609	Transcriptional regulator
H7A87_RS11925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7A87_RS11925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7A87_RS11930	COG1105	Belongs to the carbohydrate kinase PfkB family
H7A87_RS11935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7A87_RS11935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7A87_RS11945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7A87_RS11955	COG1862	Preprotein translocase
H7A87_RS12005	COG3291	Pkd domain containing protein
H7A87_RS12010	COG0405	Gamma-glutamyltransferase
H7A87_RS12015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7A87_RS12030	COG0742	ribosomal rna small subunit methyltransferase
H7A87_RS12035	COG0326	Molecular chaperone. Has ATPase activity
H7A87_RS12080	COG0531	amino acid
H7A87_RS12095	COG0006	proline dipeptidase activity
H7A87_RS12105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7A87_RS12120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7A87_RS12125	COG3938	Belongs to the proline racemase family
H7A87_RS12135	COG0552	protein localization to endoplasmic reticulum
H7A87_RS12155	COG0784	Response regulator, receiver
H7A87_RS12155	COG4191	Histidine kinase
H7A87_RS12190	COG1960	acyl-CoA dehydrogenase activity
H7A87_RS12200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7A87_RS12220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7A87_RS12225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7A87_RS12230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7A87_RS12255	COG0438	transferase activity, transferring glycosyl groups
H7A87_RS12265	COG0438	transferase activity, transferring glycosyl groups
H7A87_RS12270	COG0438	transferase activity, transferring glycosyl groups
H7A87_RS12320	COG0072	phenylalanine-tRNA ligase activity
H7A87_RS12320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7A87_RS12325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7A87_RS12340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7A87_RS12345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7A87_RS12360	COG2211	Major facilitator Superfamily
H7A87_RS12370	COG1082	Xylose isomerase domain protein TIM barrel
H7A87_RS12380	COG0366	Alpha amylase catalytic
H7A87_RS12390	COG3702	type iv secretory pathway
H7A87_RS12410	COG2948	multi-organism process
H7A87_RS12430	COG3505	Type IV secretory pathway VirD4
H7A87_RS12445	COG0556	nucleotide-excision repair
H7A87_RS12490	COG1611	Belongs to the LOG family
H7A87_RS12500	COG2095	MarC family integral membrane protein
H7A87_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS12510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7A87_RS12545	COG1185	polyribonucleotide nucleotidyltransferase activity
H7A87_RS12550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7A87_RS12555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7A87_RS12560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7A87_RS12570	COG0195	Participates in both transcription termination and antitermination
H7A87_RS12575	COG0779	Required for maturation of 30S ribosomal subunits
H7A87_RS12585	COG1007	ATP synthesis coupled electron transport
H7A87_RS12605	COG0839	Belongs to the complex I subunit 6 family
H7A87_RS12610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7A87_RS12615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7A87_RS12625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H7A87_RS12630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H7A87_RS12640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7A87_RS12650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7A87_RS12665	COG0149	triose-phosphate isomerase activity
H7A87_RS12670	COG4221	oxidoreductase activity
H7A87_RS12700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7A87_RS12705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7A87_RS12720	COG0133	tryptophan synthase activity
H7A87_RS12735	COG0101	tRNA pseudouridine synthase activity
H7A87_RS12750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7A87_RS12755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7A87_RS12760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7A87_RS12770	COG2890	protein-(glutamine-N5) methyltransferase activity
H7A87_RS12780	COG0688	phosphatidylethanolamine metabolic process
H7A87_RS12790	COG0433	COG0433 Predicted ATPase
H7A87_RS12800	COG0494	nUDIX hydrolase
H7A87_RS12815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7A87_RS12845	COG0717	Belongs to the dCTP deaminase family
H7A87_RS12850	COG0489	protein tyrosine kinase activity
H7A87_RS12865	COG3590	peptidase
H7A87_RS12870	COG3590	peptidase
H7A87_RS12890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7A87_RS12900	COG2311	Membrane
H7A87_RS12910	COG1047	Peptidyl-prolyl cis-trans
H7A87_RS12915	COG0791	NLP P60 protein
H7A87_RS12920	COG0791	NLP P60 protein
H7A87_RS12935	COG1301	dicarboxylic acid transport
H7A87_RS12940	COG1785	Belongs to the alkaline phosphatase family
H7A87_RS12945	COG0037	tRNA processing
H7A87_RS12950	COG1722	exodeoxyribonuclease VII activity
H7A87_RS12955	COG0142	geranyltranstransferase activity
H7A87_RS12960	COG4104	PAAR repeat-containing protein
H7A87_RS12970	COG0312	modulator of DNA gyrase
H7A87_RS12975	COG3028	Belongs to the UPF0307 family
H7A87_RS12980	COG0312	modulator of DNA gyrase
H7A87_RS12990	COG3164	Protein of unknown function
H7A87_RS13000	COG0424	maF-like protein
H7A87_RS13005	COG2968	Membrane
H7A87_RS13015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7A87_RS13035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7A87_RS13050	COG0495	leucyl-tRNA aminoacylation
H7A87_RS13060	COG3118	belongs to the thioredoxin family
H7A87_RS13105	COG1132	(ABC) transporter
H7A87_RS13115	COG0475	glutathione-regulated potassium exporter activity
H7A87_RS13125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7A87_RS13145	COG1187	pseudouridine synthase activity
H7A87_RS13150	COG5001	Diguanylate cyclase
H7A87_RS13150	COG5002	protein histidine kinase activity
H7A87_RS13245	COG0667	Aldo Keto reductase
H7A87_RS13250	COG2814	Major facilitator Superfamily
H7A87_RS13255	COG0583	DNA-binding transcription factor activity
H7A87_RS13265	COG2207	Transcriptional regulator
H7A87_RS13280	COG1309	transcriptional regulator
H7A87_RS13305	COG0735	belongs to the Fur family
H7A87_RS13310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7A87_RS13335	COG4452	Inner membrane protein CreD
H7A87_RS13355	COG2205	protein histidine kinase activity
H7A87_RS13360	COG0745	RESPONSE REGULATOR receiver
H7A87_RS13365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7A87_RS13375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7A87_RS13385	COG2198	Histidine kinase
H7A87_RS13385	COG0643	Histidine kinase
H7A87_RS13390	COG0840	transmembrane signaling receptor activity
H7A87_RS13395	COG0835	chemotaxis
H7A87_RS13400	COG2200	EAL domain
H7A87_RS13400	COG2202	Pas domain
H7A87_RS13400	COG2199	diguanylate cyclase activity
H7A87_RS13405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7A87_RS13415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7A87_RS13420	COG3590	peptidase
H7A87_RS13435	COG1515	deoxyribonuclease V activity
H7A87_RS13440	COG1741	Belongs to the pirin family
H7A87_RS13450	COG1741	Belongs to the pirin family
H7A87_RS13455	COG1966	Carbon starvation protein
H7A87_RS13460	COG2879	small protein
H7A87_RS13465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7A87_RS13495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7A87_RS13500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7A87_RS13505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7A87_RS13510	COG2080	2 iron, 2 sulfur cluster binding
H7A87_RS13515	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS13515	COG0604	alcohol dehydrogenase
H7A87_RS13515	COG3321	synthase
H7A87_RS13520	COG3706	GGDEF domain
H7A87_RS13520	COG4251	negative regulation of phosphorylation
H7A87_RS13520	COG2203	Gaf domain
H7A87_RS13520	COG5001	Diguanylate cyclase
H7A87_RS13525	COG0629	single-stranded DNA binding
H7A87_RS13530	COG0142	geranyltranstransferase activity
H7A87_RS13540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7A87_RS13555	COG0527	aspartate kinase activity
H7A87_RS13560	COG0384	phenazine biosynthesis protein PhzF
H7A87_RS13565	COG0384	phenazine biosynthesis protein PhzF
H7A87_RS13575	COG1764	response to oxidative stress
H7A87_RS13585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7A87_RS13590	COG1678	Uncharacterized ACR, COG1678
H7A87_RS13595	COG0519	Catalyzes the synthesis of GMP from XMP
H7A87_RS13625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7A87_RS13660	COG0693	protein deglycase activity
H7A87_RS13670	COG1959	2 iron, 2 sulfur cluster binding
H7A87_RS13675	COG0719	Fe-S assembly protein
H7A87_RS13680	COG0396	ATPase activity
H7A87_RS13685	COG0719	Fe-S assembly protein
H7A87_RS13690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7A87_RS13700	COG2146	nitrite reductase [NAD(P)H] activity
H7A87_RS13705	COG4774	siderophore transport
H7A87_RS13710	COG3128	pkhd-type hydroxylase
H7A87_RS13735	COG1477	protein flavinylation
H7A87_RS13740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7A87_RS13750	COG1555	photosystem II stabilization
H7A87_RS13755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7A87_RS13765	COG3178	'Phosphotransferase
H7A87_RS13770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7A87_RS13780	COG0628	permease
H7A87_RS13800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7A87_RS13825	COG0271	Belongs to the BolA IbaG family
H7A87_RS13835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7A87_RS13845	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7A87_RS13850	COG1137	ATPase activity
H7A87_RS13865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7A87_RS13885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7A87_RS13890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7A87_RS13895	COG2239	Acts as a magnesium transporter
H7A87_RS13905	COG1294	oxidase, subunit
H7A87_RS13910	COG1271	oxidase subunit
H7A87_RS13915	COG1113	amino acid transport
H7A87_RS13930	COG2197	response regulator
H7A87_RS13935	COG0531	amino acid
H7A87_RS13985	COG2814	Major facilitator Superfamily
H7A87_RS13990	COG0754	glutathionylspermidine amidase activity
H7A87_RS14015	COG1842	Phage shock protein A
H7A87_RS14030	COG0259	pyridoxamine-phosphate oxidase activity
H7A87_RS14035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7A87_RS14040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7A87_RS14050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7A87_RS14125	COG0477	Major facilitator Superfamily
H7A87_RS14140	COG2353	YceI-like domain
H7A87_RS14145	COG3038	cytochrome b561
H7A87_RS14160	COG1760	l-serine dehydratase
H7A87_RS14170	COG0460	homoserine dehydrogenase
H7A87_RS14170	COG0527	aspartate kinase activity
H7A87_RS14175	COG0626	cystathionine gamma-synthase activity
H7A87_RS14180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7A87_RS14185	COG0739	heme binding
H7A87_RS14190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7A87_RS14195	COG1272	protein, Hemolysin III
H7A87_RS14200	COG2982	Protein involved in outer membrane biogenesis
H7A87_RS14210	COG0463	Glycosyl transferase, family 2
H7A87_RS14215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7A87_RS14220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7A87_RS14230	COG4771	TonB-dependent receptor
H7A87_RS14235	COG1309	transcriptional regulator
H7A87_RS14245	COG1960	acyl-CoA dehydrogenase activity
H7A87_RS14270	COG0509	glycine decarboxylation via glycine cleavage system
H7A87_RS14275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7A87_RS14280	COG1742	UPF0060 membrane protein
H7A87_RS14295	COG0494	nUDIX hydrolase
H7A87_RS14305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7A87_RS14310	COG0837	glucose binding
H7A87_RS14325	COG1388	LysM domain
H7A87_RS14325	COG3858	chitin binding
H7A87_RS14330	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7A87_RS14340	COG1472	Belongs to the glycosyl hydrolase 3 family
H7A87_RS14350	COG3537	Alpha-1,2-mannosidase
H7A87_RS14380	COG1446	asparaginase
H7A87_RS14395	COG2201	protein-glutamate methylesterase activity
H7A87_RS14400	COG0643	Histidine kinase
H7A87_RS14400	COG0784	Response regulator, receiver
H7A87_RS14400	COG2198	Histidine kinase
H7A87_RS14405	COG0840	transmembrane signaling receptor activity
H7A87_RS14410	COG0835	chemotaxis
H7A87_RS14425	COG0189	ligase activity
H7A87_RS14435	COG1397	ADP-ribosylglycohydrolase
H7A87_RS14445	COG1199	ATP-dependent helicase activity
H7A87_RS14455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7A87_RS14460	COG1215	transferase activity, transferring glycosyl groups
H7A87_RS14470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7A87_RS14490	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H7A87_RS14495	COG0535	radical SAM domain protein
H7A87_RS14510	COG0837	glucose binding
H7A87_RS14525	COG1643	Atp-dependent helicase
H7A87_RS14530	COG0783	Belongs to the Dps family
H7A87_RS14535	COG0514	ATP-dependent DNA helicase (RecQ)
H7A87_RS14555	COG1187	pseudouridine synthase activity
H7A87_RS14565	COG0840	transmembrane signaling receptor activity
H7A87_RS14585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7A87_RS14605	COG0667	Aldo Keto reductase
H7A87_RS14610	COG0602	queuosine metabolic process
H7A87_RS14620	COG2885	chlorophyll binding
H7A87_RS14625	COG0823	Involved in the tonB-independent uptake of proteins
H7A87_RS14635	COG0848	biopolymer transport protein
H7A87_RS14645	COG0824	Thioesterase
H7A87_RS14650	COG2255	four-way junction helicase activity
H7A87_RS14700	COG0477	Major facilitator Superfamily
H7A87_RS14725	COG0488	(ABC) transporter
H7A87_RS14755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7A87_RS14755	COG4651	solute:proton antiporter activity
H7A87_RS14765	COG4772	TonB-dependent receptor
H7A87_RS14775	COG4264	IucA IucC family
H7A87_RS14790	COG0019	diaminopimelate decarboxylase activity
H7A87_RS14805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7A87_RS14815	COG4206	TonB-dependent receptor
H7A87_RS14830	COG0542	response to heat
H7A87_RS14835	COG1116	anion transmembrane transporter activity
H7A87_RS14840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7A87_RS14845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7A87_RS14850	COG0667	Aldo Keto reductase
H7A87_RS14855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7A87_RS14860	COG4771	TonB-dependent receptor
H7A87_RS14910	COG3387	PFAM Glycoside hydrolase 15-related
H7A87_RS14925	COG0840	transmembrane signaling receptor activity
H7A87_RS14930	COG1496	oxidoreductase activity
H7A87_RS14935	COG0564	pseudouridine synthase activity
H7A87_RS14940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7A87_RS14950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7A87_RS14950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7A87_RS14960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7A87_RS14965	COG0045	succinate-CoA ligase (ADP-forming) activity
H7A87_RS14980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7A87_RS14985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7A87_RS15015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7A87_RS15035	COG0745	RESPONSE REGULATOR receiver
H7A87_RS15045	COG0189	ligase activity
H7A87_RS15065	COG0840	transmembrane signaling receptor activity
H7A87_RS15090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7A87_RS15095	COG0471	metal ion transport
H7A87_RS15120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7A87_RS15125	COG3273	potassium ion transport
H7A87_RS15125	COG0471	metal ion transport
H7A87_RS15145	COG1970	mechanosensitive ion channel activity
H7A87_RS15155	COG1609	Transcriptional regulator
H7A87_RS15165	COG3250	beta-galactosidase activity
H7A87_RS15170	COG4948	Mandelate Racemase Muconate Lactonizing
H7A87_RS15180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7A87_RS15195	COG0308	aminopeptidase N
H7A87_RS15200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7A87_RS15205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7A87_RS15210	COG2895	sulfate adenylyltransferase (ATP) activity
H7A87_RS15210	COG0529	Catalyzes the synthesis of activated sulfate
H7A87_RS15220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7A87_RS15225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7A87_RS15230	COG0175	sulfate reduction
H7A87_RS15250	COG0784	Response regulator, receiver
H7A87_RS15250	COG2198	Histidine kinase
H7A87_RS15250	COG2205	protein histidine kinase activity
H7A87_RS15265	COG1648	precorrin-2 dehydrogenase activity
H7A87_RS15265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7A87_RS15275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H7A87_RS15280	COG3588	fructose-bisphosphate aldolase
H7A87_RS15285	COG0469	pyruvate kinase activity
H7A87_RS15315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7A87_RS15330	COG3047	cAMP biosynthetic process
H7A87_RS15340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7A87_RS15340	COG3453	Protein conserved in bacteria
H7A87_RS15345	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7A87_RS15350	COG4149	molybdate abc transporter
H7A87_RS15355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7A87_RS15395	COG1376	ErfK ybiS ycfS ynhG family protein
H7A87_RS15400	COG0739	heme binding
H7A87_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS15410	COG0583	DNA-binding transcription factor activity
H7A87_RS15415	COG4773	Receptor
H7A87_RS15420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7A87_RS15425	COG1301	dicarboxylic acid transport
H7A87_RS15455	COG0714	Associated with various cellular activities
H7A87_RS15485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7A87_RS15510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7A87_RS15520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7A87_RS15535	COG1561	YicC-like family, N-terminal region
H7A87_RS15540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7A87_RS15555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7A87_RS15570	COG0006	proline dipeptidase activity
H7A87_RS15580	COG0006	proline dipeptidase activity
H7A87_RS15625	COG2912	Transglutaminase-like superfamily
H7A87_RS15630	COG1773	rubredoxin
H7A87_RS15635	COG0352	thiamine-phosphate diphosphorylase activity
H7A87_RS15645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7A87_RS15655	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H7A87_RS15660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7A87_RS15690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7A87_RS15695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7A87_RS15710	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS15720	COG0671	phosphoesterase, PA-phosphatase related
H7A87_RS15725	COG3781	membrane
H7A87_RS15735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7A87_RS15740	COG0563	adenylate kinase activity
H7A87_RS15835	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7A87_RS15845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7A87_RS15865	COG3710	Transcriptional regulator
H7A87_RS15870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7A87_RS15875	COG0823	Involved in the tonB-independent uptake of proteins
H7A87_RS15875	COG1506	peptidase
H7A87_RS15875	COG4946	Tricorn protease homolog
H7A87_RS15885	COG0405	Gamma-glutamyltransferase
H7A87_RS15890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7A87_RS15910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7A87_RS15920	COG0066	3-isopropylmalate dehydratase activity
H7A87_RS15925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7A87_RS15945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7A87_RS15950	COG1538	Outer membrane efflux protein
H7A87_RS15960	COG1519	Transferase
H7A87_RS15965	COG1560	Kdo2-lipid A biosynthetic process
H7A87_RS15990	COG0281	malic enzyme
H7A87_RS15990	COG0280	phosphate acetyltransferase
H7A87_RS16005	COG4191	Histidine kinase
H7A87_RS16020	COG0667	Aldo Keto reductase
H7A87_RS16025	COG2197	response regulator
H7A87_RS16035	COG0642	Histidine kinase
H7A87_RS16050	COG2851	Citrate transporter
H7A87_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS16060	COG1609	Transcriptional regulator
H7A87_RS16065	COG2211	Major facilitator Superfamily
H7A87_RS16120	COG4773	Receptor
H7A87_RS16125	COG0726	polysaccharide deacetylase
H7A87_RS16130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7A87_RS16145	COG3964	amidohydrolase
H7A87_RS16150	COG0402	S-adenosylhomocysteine deaminase activity
H7A87_RS16175	COG1307	EDD domain protein, DegV family
H7A87_RS16185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7A87_RS16190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7A87_RS16215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7A87_RS16215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7A87_RS16230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7A87_RS16240	COG0488	(ABC) transporter
H7A87_RS16245	COG0242	peptide deformylase activity
H7A87_RS16310	COG2188	Transcriptional regulator
H7A87_RS16320	COG1450	Type ii and iii secretion system protein
H7A87_RS16335	COG3166	PFAM Fimbrial assembly family protein
H7A87_RS16340	COG3156	type II secretion system protein K
H7A87_RS16345	COG4795	General secretion pathway protein
H7A87_RS16350	COG2165	general secretion pathway protein
H7A87_RS16355	COG4970	Tfp pilus assembly protein FimT
H7A87_RS16360	COG2165	general secretion pathway protein
H7A87_RS16365	COG1459	type II secretion system
H7A87_RS16370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7A87_RS16375	COG1404	Belongs to the peptidase S8 family
H7A87_RS16380	COG5295	Hep Hag repeat protein
H7A87_RS16385	COG1404	Belongs to the peptidase S8 family
H7A87_RS16390	COG5295	Hep Hag repeat protein
H7A87_RS16395	COG0047	phosphoribosylformylglycinamidine synthase activity
H7A87_RS16395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7A87_RS16400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7A87_RS16405	COG4974	Belongs to the 'phage' integrase family
H7A87_RS16415	COG0795	lipopolysaccharide-transporting ATPase activity
H7A87_RS16455	COG1183	phosphatidylcholine synthase activity
H7A87_RS16465	COG0442	prolyl-tRNA aminoacylation
H7A87_RS16480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7A87_RS16485	COG1127	ABC transporter
H7A87_RS16490	COG3218	ABC-type transport auxiliary lipoprotein component
H7A87_RS16490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7A87_RS16520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7A87_RS16525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7A87_RS16530	COG0662	Cupin 2, conserved barrel domain protein
H7A87_RS16530	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H7A87_RS16555	COG2086	electron transfer activity
H7A87_RS16570	COG0463	Glycosyl transferase, family 2
H7A87_RS16585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7A87_RS16590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H7A87_RS16605	COG0438	transferase activity, transferring glycosyl groups
H7A87_RS16630	COG0626	cystathionine gamma-synthase activity
H7A87_RS16660	COG0625	glutathione transferase activity
H7A87_RS16670	COG0513	Belongs to the DEAD box helicase family
H7A87_RS16680	COG4771	TonB-dependent receptor
H7A87_RS16685	COG0720	synthase
H7A87_RS16695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7A87_RS16700	COG1956	GAF domain-containing protein
H7A87_RS16710	COG2819	hydrolase of the alpha beta superfamily
H7A87_RS16720	COG0546	phosphoglycolate phosphatase activity
H7A87_RS16725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7A87_RS16730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7A87_RS16740	COG0339	signal peptide processing
H7A87_RS16775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7A87_RS16780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7A87_RS16785	COG1136	(ABC) transporter
H7A87_RS16790	COG0577	efflux transmembrane transporter activity
H7A87_RS16815	COG4191	Histidine kinase
H7A87_RS16825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7A87_RS16860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7A87_RS16865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7A87_RS16875	COG0356	it plays a direct role in the translocation of protons across the membrane
H7A87_RS16895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7A87_RS16905	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7A87_RS16940	COG2011	ABC-type metal ion transport system permease component
H7A87_RS16945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7A87_RS16950	COG0697	spore germination
H7A87_RS16955	COG1666	GTP binding
H7A87_RS16985	COG1187	pseudouridine synthase activity
H7A87_RS17010	COG2205	protein histidine kinase activity
H7A87_RS17030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7A87_RS17035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7A87_RS17085	COG0842	Transport permease protein
H7A87_RS17090	COG1131	(ABC) transporter
H7A87_RS17095	COG0025	NhaP-type Na H and K H
H7A87_RS17105	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7A87_RS17110	COG1573	uracil-dna glycosylase
H7A87_RS17120	COG3384	dioxygenase
H7A87_RS17130	COG0583	DNA-binding transcription factor activity
H7A87_RS17140	COG0667	Aldo Keto reductase
H7A87_RS17150	COG3590	peptidase
H7A87_RS17165	COG0531	amino acid
H7A87_RS17180	COG2972	Histidine kinase
H7A87_RS17195	COG3685	Protein conserved in bacteria
H7A87_RS17200	COG3546	catalase activity
H7A87_RS17225	COG2204	response regulator
H7A87_RS17235	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS17240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7A87_RS17260	COG1132	(ABC) transporter
H7A87_RS17270	COG1063	alcohol dehydrogenase
H7A87_RS17335	COG1131	(ABC) transporter
H7A87_RS17355	COG0840	transmembrane signaling receptor activity
H7A87_RS17390	COG0659	secondary active sulfate transmembrane transporter activity
H7A87_RS17395	COG0038	chloride channel
H7A87_RS17400	COG0024	Methionine aminopeptidase
H7A87_RS17415	COG1309	transcriptional regulator
H7A87_RS17425	COG1902	pentaerythritol trinitrate reductase activity
H7A87_RS17430	COG1309	transcriptional regulator
H7A87_RS17480	COG1846	Transcriptional regulator
H7A87_RS17610	COG0210	DNA helicase
H7A87_RS17650	COG4983	Phage plasmid primase, P4 family domain protein
H7A87_RS17685	COG2003	Belongs to the UPF0758 family
H7A87_RS17705	COG0840	transmembrane signaling receptor activity
H7A87_RS17710	COG1309	transcriptional regulator
H7A87_RS17745	COG2807	transmembrane transport
H7A87_RS17750	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7A87_RS17760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7A87_RS17765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7A87_RS17775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7A87_RS17840	COG3791	Glutathione-dependent formaldehyde-activating
H7A87_RS17860	COG1942	4-Oxalocrotonate Tautomerase
H7A87_RS17865	COG2267	carboxylic ester hydrolase activity
H7A87_RS17870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7A87_RS17890	COG2814	Major facilitator Superfamily
H7A87_RS17895	COG0612	Peptidase, M16
H7A87_RS17920	COG0848	biopolymer transport protein
H7A87_RS17930	COG0583	DNA-binding transcription factor activity
H7A87_RS17945	COG2259	Doxx family
H7A87_RS17950	COG3384	dioxygenase
H7A87_RS17970	COG1538	Outer membrane efflux protein
H7A87_RS17985	COG3713	MltA-interacting MipA family protein
H7A87_RS17990	COG2853	Lipoprotein
H7A87_RS18000	COG0640	Transcriptional regulator
H7A87_RS18060	COG4191	Histidine kinase
H7A87_RS18060	COG0784	Response regulator, receiver
H7A87_RS18100	COG2194	sulfuric ester hydrolase activity
H7A87_RS18110	COG0582	viral genome integration into host DNA
H7A87_RS18125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7A87_RS18130	COG1490	D-aminoacyl-tRNA deacylase activity
H7A87_RS18145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7A87_RS18180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7A87_RS18180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7A87_RS18185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7A87_RS18190	COG0242	peptide deformylase activity
H7A87_RS18195	COG1652	LysM domain
H7A87_RS18200	COG0758	DNA mediated transformation
H7A87_RS18220	COG1754	DNA topoisomerase type I activity
H7A87_RS18220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7A87_RS18225	COG0009	L-threonylcarbamoyladenylate synthase
H7A87_RS18240	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS18250	COG0616	signal peptide processing
H7A87_RS18255	COG0534	Mate efflux family protein
H7A87_RS18270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7A87_RS18275	COG0625	glutathione transferase activity
H7A87_RS18290	COG1252	NADH dehydrogenase
H7A87_RS18295	COG2860	membrane
H7A87_RS18300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7A87_RS18305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7A87_RS18310	COG2201	protein-glutamate methylesterase activity
H7A87_RS18315	COG2177	Part of the ABC transporter FtsEX involved in
H7A87_RS18320	COG2884	Cell division ATP-binding protein ftsE
H7A87_RS18330	COG3118	belongs to the thioredoxin family
H7A87_RS18335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7A87_RS18340	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7A87_RS18355	COG1652	LysM domain
H7A87_RS18360	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7A87_RS18360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7A87_RS18365	COG1473	amidohydrolase
H7A87_RS18375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7A87_RS18385	COG5383	Protein conserved in bacteria
H7A87_RS18425	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H7A87_RS18445	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7A87_RS18455	COG4948	Mandelate Racemase Muconate Lactonizing
H7A87_RS18465	COG0531	amino acid
H7A87_RS18480	COG2133	pyrroloquinoline quinone binding
H7A87_RS18490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7A87_RS18505	COG1610	YqeY-like protein
H7A87_RS18510	COG1295	ribonuclease BN
H7A87_RS18515	COG0358	DNA primase activity
H7A87_RS18530	COG0109	protoheme IX farnesyltransferase activity
H7A87_RS18560	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H7A87_RS18575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7A87_RS18620	COG0739	heme binding
H7A87_RS18625	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7A87_RS18635	COG2211	Major facilitator Superfamily
H7A87_RS18640	COG0708	Exodeoxyribonuclease III
H7A87_RS18655	COG1192	Involved in chromosome partitioning
H7A87_RS18660	COG1475	DNA binding
H7A87_RS18680	COG0463	Glycosyl transferase, family 2
H7A87_RS18705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7A87_RS18715	COG0018	arginyl-trna synthetase
H7A87_RS18730	COG4221	oxidoreductase activity
H7A87_RS18735	COG2755	lipolytic protein G-D-S-L family
H7A87_RS18735	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7A87_RS18745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7A87_RS18755	COG1166	arginine decarboxylase activity
H7A87_RS18760	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7A87_RS18795	COG0606	chelatase, subunit chli
H7A87_RS18810	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H7A87_RS18865	COG1090	epimerase
H7A87_RS18875	COG0642	Histidine kinase
H7A87_RS18895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7A87_RS18915	COG0628	permease
H7A87_RS18920	COG1011	Hydrolase
H7A87_RS18925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7A87_RS18945	COG2197	response regulator
H7A87_RS18950	COG4585	Histidine kinase
H7A87_RS18955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7A87_RS18960	COG1136	(ABC) transporter
H7A87_RS18985	COG0697	spore germination
H7A87_RS19005	COG0180	Tryptophanyl-tRNA synthetase
H7A87_RS19010	COG3237	CsbD-like
H7A87_RS19050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7A87_RS19065	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7A87_RS19070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7A87_RS19070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7A87_RS19110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7A87_RS19145	COG1199	ATP-dependent helicase activity
H7A87_RS19200	COG0625	glutathione transferase activity
H7A87_RS19235	COG4555	ABC transporter
H7A87_RS19245	COG1476	TRANSCRIPTIONal
H7A87_RS19270	COG0633	Ferredoxin
H7A87_RS19270	COG0543	2 iron, 2 sulfur cluster binding
H7A87_RS19275	COG1131	(ABC) transporter
H7A87_RS19280	COG0842	Transport permease protein
H7A87_RS19285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7A87_RS19295	COG1607	acyl-coa hydrolase
H7A87_RS19310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7A87_RS19315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7A87_RS19325	COG1042	CoA-binding domain protein
H7A87_RS19325	COG0045	succinate-CoA ligase (ADP-forming) activity
H7A87_RS19325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7A87_RS19340	COG1629	transport
H7A87_RS19340	COG4771	TonB-dependent receptor
H7A87_RS19345	COG2239	Acts as a magnesium transporter
H7A87_RS19355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7A87_RS19360	COG3387	PFAM Glycoside hydrolase 15-related
H7A87_RS19375	COG3100	YcgL domain-containing protein
H7A87_RS19380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7A87_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS19425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7A87_RS19440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7A87_RS19520	COG0210	DNA helicase
H7A87_RS19530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7A87_RS19540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7A87_RS19550	COG2159	amidohydrolase
H7A87_RS19570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7A87_RS19590	COG0357	Ribosomal RNA small subunit methyltransferase G
H7A87_RS19600	COG3540	Alkaline phosphatase
H7A87_RS19610	COG2091	lysine biosynthetic process via aminoadipic acid
H7A87_RS19640	COG1940	carbohydrate kinase activity
H7A87_RS19660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7A87_RS19675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7A87_RS19715	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS19720	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7A87_RS19725	COG4948	Mandelate Racemase Muconate Lactonizing
H7A87_RS19730	COG3254	rhamnose metabolic process
H7A87_RS19735	COG0738	Major facilitator superfamily
H7A87_RS19740	COG1414	Transcriptional regulator
H7A87_RS19745	COG1971	Probably functions as a manganese efflux pump
H7A87_RS19760	COG2205	protein histidine kinase activity
H7A87_RS19765	COG3459	Glycosyltransferase 36 associated
H7A87_RS19770	COG2211	Major facilitator Superfamily
H7A87_RS19775	COG3265	gluconokinase activity
H7A87_RS19780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7A87_RS19800	COG2911	Protein conserved in bacteria
H7A87_RS19805	COG0729	surface antigen
H7A87_RS19810	COG4771	TonB-dependent receptor
H7A87_RS19815	COG0457	Tetratricopeptide repeat
H7A87_RS19830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7A87_RS19835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7A87_RS19835	COG0519	Catalyzes the synthesis of GMP from XMP
H7A87_RS19845	COG0805	protein transport
H7A87_RS19850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7A87_RS19855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7A87_RS19865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7A87_RS19880	COG2974	May be involved in recombination
H7A87_RS19885	COG0037	tRNA processing
H7A87_RS19890	COG2115	Belongs to the xylose isomerase family
H7A87_RS19900	COG3661	Belongs to the glycosyl hydrolase 67 family
H7A87_RS19910	COG4948	Mandelate Racemase Muconate Lactonizing
H7A87_RS19920	COG1472	Belongs to the glycosyl hydrolase 3 family
H7A87_RS19925	COG0246	Mannitol dehydrogenase
H7A87_RS19950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7A87_RS19955	COG1620	l-lactate permease
H7A87_RS19975	COG3386	PFAM SMP-30 Gluconolaconase
H7A87_RS19985	COG3250	beta-galactosidase activity
H7A87_RS19990	COG1904	glucuronate isomerase
H7A87_RS19995	COG3693	PFAM glycoside hydrolase, family 10
H7A87_RS20010	COG2211	Major facilitator Superfamily
H7A87_RS20040	COG2937	Belongs to the GPAT DAPAT family
H7A87_RS20070	COG0284	orotidine-5'-phosphate decarboxylase activity
H7A87_RS20075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H7A87_RS20080	COG3132	Protein of unknown function, DUF480
H7A87_RS20100	COG0210	DNA helicase
H7A87_RS20105	COG1435	thymidine kinase activity
H7A87_RS20115	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H7A87_RS20125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7A87_RS20155	COG3135	benzoate transporter
H7A87_RS20180	COG0676	glucose-6-phosphate 1-epimerase activity
H7A87_RS20195	COG0730	response to heat
H7A87_RS20220	COG0302	gtp cyclohydrolase
H7A87_RS20235	COG1566	PFAM secretion protein HlyD family protein
H7A87_RS20245	COG1289	transmembrane transporter activity
H7A87_RS20250	COG0477	Major facilitator Superfamily
H7A87_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
H7A87_RS20265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7A87_RS20285	COG4691	Plasmid stability protein
H7A87_RS20290	COG1487	ribonuclease activity
H7A87_RS20360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7A87_RS20365	COG1074	ATP-dependent DNA helicase activity
H7A87_RS20370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7A87_RS20405	COG1127	ABC transporter
H7A87_RS20410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7A87_RS20415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7A87_RS20430	COG2853	Lipoprotein
H7A87_RS20440	COG0386	Belongs to the glutathione peroxidase family
H7A87_RS20450	COG1322	Protein conserved in bacteria
H7A87_RS20455	COG0604	alcohol dehydrogenase
H7A87_RS20465	COG0625	glutathione transferase activity
H7A87_RS20475	COG0531	amino acid
H7A87_RS20480	COG3537	Alpha-1,2-mannosidase
H7A87_RS20490	COG3706	GGDEF domain
H7A87_RS20495	COG3835	regulator
H7A87_RS20500	COG1929	Belongs to the glycerate kinase type-1 family
H7A87_RS20505	COG2271	Major facilitator Superfamily
H7A87_RS20545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7A87_RS20550	COG0861	Integral membrane protein TerC family
H7A87_RS20560	COG0584	glycerophosphoryl diester phosphodiesterase
H7A87_RS20570	COG0671	phosphoesterase, PA-phosphatase related
H7A87_RS20585	COG0706	membrane insertase activity
H7A87_RS20665	COG1192	Involved in chromosome partitioning