locus-tag	class	description
HEP73_RS00010	COG0592	DNA-directed DNA polymerase activity
HEP73_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP73_RS00020	COG0187	DNA topoisomerase II activity
HEP73_RS00025	COG1266	CAAX protease self-immunity
HEP73_RS00030	COG0501	Belongs to the peptidase M48B family
HEP73_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_RS00110	COG1280	lysine exporter protein (LysE YggA)
HEP73_RS00135	COG4772	TonB-dependent receptor
HEP73_RS00150	COG3284	Transcriptional regulator
HEP73_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_RS00200	COG0277	FAD linked oxidase domain protein
HEP73_RS00210	COG2186	Transcriptional regulator
HEP73_RS00225	COG4585	Histidine kinase
HEP73_RS00230	COG2197	response regulator
HEP73_RS00265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_RS00265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_RS00280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP73_RS00375	COG4771	TonB-dependent receptor
HEP73_RS00425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEP73_RS00440	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP73_RS00445	COG1609	Transcriptional regulator
HEP73_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS00465	COG2755	lipolytic protein G-D-S-L family
HEP73_RS00475	COG3186	Phenylalanine-4-hydroxylase
HEP73_RS00480	COG1522	sequence-specific DNA binding
HEP73_RS00495	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEP73_RS00505	COG1595	DNA-templated transcription, initiation
HEP73_RS00515	COG3220	belongs to the UPF0276 family
HEP73_RS00570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HEP73_RS00605	COG1929	Belongs to the glycerate kinase type-1 family
HEP73_RS00615	COG2814	Major facilitator Superfamily
HEP73_RS00635	COG0531	amino acid
HEP73_RS00640	COG4566	intracellular signal transduction
HEP73_RS00645	COG4191	Histidine kinase
HEP73_RS00660	COG0625	glutathione transferase activity
HEP73_RS00665	COG1322	Protein conserved in bacteria
HEP73_RS00675	COG0386	Belongs to the glutathione peroxidase family
HEP73_RS00680	COG2853	Lipoprotein
HEP73_RS00695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP73_RS00700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP73_RS00705	COG1127	ABC transporter
HEP73_RS00740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEP73_RS00745	COG1074	ATP-dependent DNA helicase activity
HEP73_RS00750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP73_RS00780	COG0537	adenosine 5'-monophosphoramidase activity
HEP73_RS00835	COG0477	Major facilitator Superfamily
HEP73_RS00840	COG0302	gtp cyclohydrolase
HEP73_RS00865	COG0730	response to heat
HEP73_RS00885	COG2951	lytic endotransglycosylase activity
HEP73_RS00910	COG3135	benzoate transporter
HEP73_RS00945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP73_RS00950	COG1803	Methylglyoxal synthase
HEP73_RS00955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_RS00960	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_RS00965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_RS00975	COG0493	'glutamate synthase
HEP73_RS00980	COG0070	glutamate synthase
HEP73_RS00980	COG0069	glutamate synthase activity
HEP73_RS00980	COG0067	glutamate synthase
HEP73_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS01030	COG1205	dead DEAH box helicase
HEP73_RS01030	COG1111	helicase
HEP73_RS01035	COG3549	Plasmid maintenance system killer
HEP73_RS01090	COG2271	Major facilitator Superfamily
HEP73_RS01100	COG0657	acetylesterase activity
HEP73_RS01155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP73_RS01160	COG1192	Involved in chromosome partitioning
HEP73_RS01175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_RS01180	COG2050	protein possibly involved in aromatic compounds catabolism
HEP73_RS01200	COG1881	PFAM PEBP family protein
HEP73_RS01210	COG0174	glutamine synthetase
HEP73_RS01215	COG0347	Belongs to the P(II) protein family
HEP73_RS01220	COG0004	ammonium transporteR
HEP73_RS01225	COG3852	Histidine kinase
HEP73_RS01230	COG2204	response regulator
HEP73_RS01235	COG2032	superoxide dismutase activity
HEP73_RS01240	COG2032	superoxide dismutase activity
HEP73_RS01250	COG0183	Belongs to the thiolase family
HEP73_RS01295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP73_RS01315	COG0702	epimerase
HEP73_RS01320	COG0583	DNA-binding transcription factor activity
HEP73_RS01335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEP73_RS01345	COG0612	Peptidase, M16
HEP73_RS01355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_RS01365	COG0596	Alpha beta hydrolase
HEP73_RS01375	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEP73_RS01380	COG0318	PFAM AMP-dependent synthetase and ligase
HEP73_RS01395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_RS01405	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP73_RS01430	COG0564	pseudouridine synthase activity
HEP73_RS01460	COG1595	DNA-templated transcription, initiation
HEP73_RS01465	COG1446	asparaginase
HEP73_RS01470	COG0339	signal peptide processing
HEP73_RS01475	COG0681	Belongs to the peptidase S26 family
HEP73_RS01500	COG0583	DNA-binding transcription factor activity
HEP73_RS01505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP73_RS01510	COG2224	Isocitrate lyase
HEP73_RS01545	COG0659	secondary active sulfate transmembrane transporter activity
HEP73_RS01580	COG0583	DNA-binding transcription factor activity
HEP73_RS01585	COG1959	2 iron, 2 sulfur cluster binding
HEP73_RS01595	COG1690	Belongs to the RtcB family
HEP73_RS01615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP73_RS01620	COG2130	NADP-dependent
HEP73_RS01635	COG1187	pseudouridine synthase activity
HEP73_RS01655	COG0084	hydrolase, TatD family'
HEP73_RS01760	COG0842	Transport permease protein
HEP73_RS01765	COG1131	(ABC) transporter
HEP73_RS01770	COG0543	2 iron, 2 sulfur cluster binding
HEP73_RS01770	COG0633	Ferredoxin
HEP73_RS01775	COG0662	Cupin 2, conserved barrel domain protein
HEP73_RS01775	COG2207	Transcriptional regulator
HEP73_RS01790	COG1476	TRANSCRIPTIONal
HEP73_RS01800	COG4555	ABC transporter
HEP73_RS01820	COG0625	glutathione transferase activity
HEP73_RS01855	COG0028	Belongs to the TPP enzyme family
HEP73_RS01880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_RS01900	COG1199	ATP-dependent helicase activity
HEP73_RS01970	COG0628	permease
HEP73_RS02005	COG2133	pyrroloquinoline quinone binding
HEP73_RS02080	COG5463	Belongs to the UPF0441 family
HEP73_RS02085	COG0754	glutathionylspermidine amidase activity
HEP73_RS02095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP73_RS02155	COG0714	Associated with various cellular activities
HEP73_RS02190	COG1522	sequence-specific DNA binding
HEP73_RS02195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEP73_RS02210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS02215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_RS02225	COG3541	Predicted nucleotidyltransferase
HEP73_RS02240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP73_RS02280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP73_RS02290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP73_RS02305	COG2267	carboxylic ester hydrolase activity
HEP73_RS02315	COG2960	long-chain fatty acid transporting porin activity
HEP73_RS02345	COG1166	arginine decarboxylase activity
HEP73_RS02350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP73_RS02350	COG2755	lipolytic protein G-D-S-L family
HEP73_RS02360	COG0583	DNA-binding transcription factor activity
HEP73_RS02380	COG4221	oxidoreductase activity
HEP73_RS02400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEP73_RS02420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP73_RS02430	COG2814	Major facilitator Superfamily
HEP73_RS02440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEP73_RS02445	COG0739	heme binding
HEP73_RS02450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP73_RS02485	COG1064	alcohol dehydrogenase
HEP73_RS02490	COG2234	aminopeptidase activity
HEP73_RS02500	COG4942	peptidase
HEP73_RS02505	COG0793	Belongs to the peptidase S41A family
HEP73_RS02535	COG0531	amino acid
HEP73_RS02545	COG1486	melibiose metabolic process
HEP73_RS02560	COG1565	acr, cog1565
HEP73_RS02560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP73_RS02570	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HEP73_RS02575	COG1845	cytochrome c oxidase, subunit III
HEP73_RS02600	COG0109	protoheme IX farnesyltransferase activity
HEP73_RS02620	COG0358	DNA primase activity
HEP73_RS02625	COG1295	ribonuclease BN
HEP73_RS02630	COG1610	YqeY-like protein
HEP73_RS02645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP73_RS02650	COG2308	Evidence 4 Homologs of previously reported genes of
HEP73_RS02665	COG2133	pyrroloquinoline quinone binding
HEP73_RS02685	COG0531	amino acid
HEP73_RS02695	COG4948	Mandelate Racemase Muconate Lactonizing
HEP73_RS02705	COG4771	TonB-dependent receptor
HEP73_RS02710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP73_RS02745	COG3409	Peptidoglycan-binding domain 1 protein
HEP73_RS02745	COG3501	Rhs element vgr protein
HEP73_RS02755	COG0477	Major facilitator Superfamily
HEP73_RS02760	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEP73_RS02795	COG5383	Protein conserved in bacteria
HEP73_RS02815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS02830	COG1652	LysM domain
HEP73_RS02855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP73_RS02860	COG3118	belongs to the thioredoxin family
HEP73_RS02870	COG2884	Cell division ATP-binding protein ftsE
HEP73_RS02875	COG2177	Part of the ABC transporter FtsEX involved in
HEP73_RS02880	COG2201	protein-glutamate methylesterase activity
HEP73_RS02885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP73_RS02890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP73_RS02895	COG2860	membrane
HEP73_RS02900	COG1252	NADH dehydrogenase
HEP73_RS02910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEP73_RS02920	COG0534	Mate efflux family protein
HEP73_RS02925	COG0616	signal peptide processing
HEP73_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS02950	COG0009	L-threonylcarbamoyladenylate synthase
HEP73_RS02955	COG1754	DNA topoisomerase type I activity
HEP73_RS02955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP73_RS02960	COG1714	RDD family
HEP73_RS02975	COG0758	DNA mediated transformation
HEP73_RS02980	COG1652	LysM domain
HEP73_RS02985	COG0242	peptide deformylase activity
HEP73_RS02995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEP73_RS02995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP73_RS03000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP73_RS03010	COG3307	-O-antigen
HEP73_RS03015	COG0463	Glycosyl transferase, family 2
HEP73_RS03035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP73_RS03050	COG1490	D-aminoacyl-tRNA deacylase activity
HEP73_RS03055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP73_RS03070	COG1609	Transcriptional regulator
HEP73_RS03075	COG3537	Alpha-1,2-mannosidase
HEP73_RS03080	COG1733	regulation of RNA biosynthetic process
HEP73_RS03090	COG0366	Alpha amylase catalytic
HEP73_RS03095	COG0366	Alpha amylase catalytic
HEP73_RS03100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP73_RS03155	COG2207	Transcriptional regulator
HEP73_RS03160	COG2963	transposase activity
HEP73_RS03195	COG0300	oxidoreductase activity
HEP73_RS03210	COG3550	peptidyl-serine autophosphorylation
HEP73_RS03240	COG1309	transcriptional regulator
HEP73_RS03245	COG0604	alcohol dehydrogenase
HEP73_RS03260	COG0024	Methionine aminopeptidase
HEP73_RS03290	COG4773	Receptor
HEP73_RS03295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS03300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_RS03305	COG1538	Outer membrane efflux protein
HEP73_RS03315	COG2207	Transcriptional regulator
HEP73_RS03330	COG1309	transcriptional regulator
HEP73_RS03350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_RS03350	COG2124	cytochrome p450
HEP73_RS03355	COG1309	transcriptional regulator
HEP73_RS03365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP73_RS03370	COG2271	Major facilitator Superfamily
HEP73_RS03395	COG0745	RESPONSE REGULATOR receiver
HEP73_RS03400	COG4932	domain protein
HEP73_RS03400	COG3266	domain, Protein
HEP73_RS03400	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HEP73_RS03420	COG0840	transmembrane signaling receptor activity
HEP73_RS03440	COG3546	catalase activity
HEP73_RS03445	COG3685	Protein conserved in bacteria
HEP73_RS03450	COG3685	Protein conserved in bacteria
HEP73_RS03455	COG0588	phosphoglycerate mutase activity
HEP73_RS03460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP73_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS03475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP73_RS03510	COG0028	Belongs to the TPP enzyme family
HEP73_RS03515	COG4191	Histidine kinase
HEP73_RS03520	COG2204	response regulator
HEP73_RS03540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP73_RS03540	COG1648	precorrin-2 dehydrogenase activity
HEP73_RS03550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEP73_RS03550	COG1116	anion transmembrane transporter activity
HEP73_RS03580	COG2223	nitrite transmembrane transporter activity
HEP73_RS03585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP73_RS03590	COG2146	nitrite reductase [NAD(P)H] activity
HEP73_RS03595	COG0243	molybdopterin cofactor binding
HEP73_RS03625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP73_RS03635	COG0297	glycogen (starch) synthase activity
HEP73_RS03645	COG0745	RESPONSE REGULATOR receiver
HEP73_RS03655	COG1335	isochorismatase
HEP73_RS03680	COG0181	hydroxymethylbilane synthase activity
HEP73_RS03695	COG1733	regulation of RNA biosynthetic process
HEP73_RS03710	COG1505	serine-type exopeptidase activity
HEP73_RS03715	COG0436	Aminotransferase
HEP73_RS03725	COG2832	Protein of unknown function (DUF454)
HEP73_RS03760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HEP73_RS03790	COG2226	methyltransferase
HEP73_RS03795	COG0308	aminopeptidase N
HEP73_RS03800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP73_RS03800	COG0596	Alpha beta hydrolase
HEP73_RS03825	COG2010	Cytochrome c
HEP73_RS03835	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP73_RS03845	COG3284	Transcriptional regulator
HEP73_RS03860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP73_RS03865	COG1077	Cell shape determining protein MreB Mrl
HEP73_RS03870	COG1792	Involved in formation and maintenance of cell shape
HEP73_RS03880	COG0768	penicillin binding
HEP73_RS03885	COG0772	Belongs to the SEDS family
HEP73_RS03895	COG2951	lytic endotransglycosylase activity
HEP73_RS03905	COG1686	Belongs to the peptidase S11 family
HEP73_RS03920	COG0321	lipoyl(octanoyl) transferase activity
HEP73_RS03925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP73_RS03955	COG1051	belongs to the nudix hydrolase family
HEP73_RS03955	COG1056	cytidyltransferase-related domain
HEP73_RS03985	COG1090	epimerase
HEP73_RS03995	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP73_RS04000	COG0673	inositol 2-dehydrogenase activity
HEP73_RS04005	COG2823	Periplasmic or secreted lipoprotein
HEP73_RS04015	COG2205	protein histidine kinase activity
HEP73_RS04015	COG2202	Pas domain
HEP73_RS04020	COG0784	Response regulator, receiver
HEP73_RS04025	COG4191	Histidine kinase
HEP73_RS04035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP73_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS04055	COG4305	rare lipoprotein A
HEP73_RS04075	COG3250	beta-galactosidase activity
HEP73_RS04090	COG2188	Transcriptional regulator
HEP73_RS04100	COG1609	Transcriptional regulator
HEP73_RS04105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP73_RS04110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEP73_RS04115	COG3001	Fructosamine kinase
HEP73_RS04140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP73_RS04155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HEP73_RS04165	COG2207	Transcriptional regulator
HEP73_RS04210	COG3738	Protein conserved in bacteria
HEP73_RS04220	COG2205	protein histidine kinase activity
HEP73_RS04240	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP73_RS04245	COG3791	Glutathione-dependent formaldehyde-activating
HEP73_RS04260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP73_RS04270	COG0697	spore germination
HEP73_RS04280	COG1307	EDD domain protein, DegV family
HEP73_RS04300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP73_RS04315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP73_RS04405	COG0436	Aminotransferase
HEP73_RS04410	COG1162	GTPase activity
HEP73_RS04440	COG2211	Major facilitator Superfamily
HEP73_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS04455	COG2851	Citrate transporter
HEP73_RS04470	COG0642	Histidine kinase
HEP73_RS04480	COG0745	RESPONSE REGULATOR receiver
HEP73_RS04480	COG0745	RESPONSE REGULATOR receiver
HEP73_RS04480	COG2205	protein histidine kinase activity
HEP73_RS04480	COG2205	protein histidine kinase activity
HEP73_RS04480	COG3292	Two component regulator propeller
HEP73_RS04480	COG3292	Two component regulator propeller
HEP73_RS04495	COG4191	Histidine kinase
HEP73_RS04505	COG1301	dicarboxylic acid transport
HEP73_RS04510	COG0280	phosphate acetyltransferase
HEP73_RS04510	COG0281	malic enzyme
HEP73_RS04535	COG1560	Kdo2-lipid A biosynthetic process
HEP73_RS04540	COG1519	Transferase
HEP73_RS04545	COG1538	Outer membrane efflux protein
HEP73_RS04550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP73_RS04565	COG0473	3-isopropylmalate dehydrogenase activity
HEP73_RS04570	COG0066	3-isopropylmalate dehydratase activity
HEP73_RS04585	COG4106	trans-aconitate 2-methyltransferase activity
HEP73_RS04590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP73_RS04610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP73_RS04620	COG2815	serine threonine protein kinase
HEP73_RS04620	COG0515	serine threonine protein kinase
HEP73_RS04625	COG0405	Gamma-glutamyltransferase
HEP73_RS04630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HEP73_RS04635	COG0840	transmembrane signaling receptor activity
HEP73_RS04650	COG0823	Involved in the tonB-independent uptake of proteins
HEP73_RS04670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP73_RS04680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP73_RS04710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP73_RS04720	COG0671	phosphoesterase, PA-phosphatase related
HEP73_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS04735	COG1940	carbohydrate kinase activity
HEP73_RS04740	COG0346	lactoylglutathione lyase activity
HEP73_RS04745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP73_RS04750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP73_RS04760	COG4206	TonB-dependent receptor
HEP73_RS04770	COG2010	Cytochrome c
HEP73_RS04780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP73_RS04785	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HEP73_RS04790	COG2909	trisaccharide binding
HEP73_RS04795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP73_RS04810	COG1773	rubredoxin
HEP73_RS04835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP73_RS04865	COG3079	Belongs to the UPF0149 family
HEP73_RS04870	COG0006	proline dipeptidase activity
HEP73_RS04875	COG0006	proline dipeptidase activity
HEP73_RS04890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP73_RS04895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP73_RS04900	COG0346	lactoylglutathione lyase activity
HEP73_RS04905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP73_RS04910	COG1561	YicC-like family, N-terminal region
HEP73_RS04915	COG0194	GDP metabolic process
HEP73_RS04920	COG1758	RNA polymerase activity
HEP73_RS04925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP73_RS04935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP73_RS04945	COG0254	rRNA binding
HEP73_RS04950	COG0372	Belongs to the citrate synthase family
HEP73_RS04965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP73_RS04995	COG0714	Associated with various cellular activities
HEP73_RS05025	COG1301	dicarboxylic acid transport
HEP73_RS05030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP73_RS05055	COG0739	heme binding
HEP73_RS05060	COG1376	ErfK ybiS ycfS ynhG family protein
HEP73_RS05100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HEP73_RS05105	COG4149	molybdate abc transporter
HEP73_RS05110	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP73_RS05120	COG0640	Transcriptional regulator
HEP73_RS05135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_RS05140	COG3591	Belongs to the peptidase S1B family
HEP73_RS05170	COG3047	cAMP biosynthetic process
HEP73_RS05175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP73_RS05195	COG4221	oxidoreductase activity
HEP73_RS05200	COG4221	oxidoreductase activity
HEP73_RS05210	COG3321	synthase
HEP73_RS05210	COG0604	alcohol dehydrogenase
HEP73_RS05215	COG0840	transmembrane signaling receptor activity
HEP73_RS05240	COG0469	pyruvate kinase activity
HEP73_RS05245	COG3588	fructose-bisphosphate aldolase
HEP73_RS05255	COG2205	protein histidine kinase activity
HEP73_RS05270	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP73_RS05300	COG1648	precorrin-2 dehydrogenase activity
HEP73_RS05300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP73_RS05315	COG2205	protein histidine kinase activity
HEP73_RS05315	COG2198	Histidine kinase
HEP73_RS05315	COG0784	Response regulator, receiver
HEP73_RS05320	COG0431	NADPH-dependent FMN reductase
HEP73_RS05325	COG1393	Belongs to the ArsC family
HEP73_RS05350	COG0175	sulfate reduction
HEP73_RS05355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP73_RS05360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_RS05370	COG0529	Catalyzes the synthesis of activated sulfate
HEP73_RS05370	COG2895	sulfate adenylyltransferase (ATP) activity
HEP73_RS05380	COG0438	transferase activity, transferring glycosyl groups
HEP73_RS05400	COG1115	amino acid carrier protein
HEP73_RS05410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP73_RS05420	COG1609	Transcriptional regulator
HEP73_RS05435	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP73_RS05450	COG3273	potassium ion transport
HEP73_RS05450	COG0471	metal ion transport
HEP73_RS05460	COG2022	thiamine diphosphate biosynthetic process
HEP73_RS05485	COG3511	phospholipase C
HEP73_RS05495	COG0189	ligase activity
HEP73_RS05505	COG0745	RESPONSE REGULATOR receiver
HEP73_RS05520	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEP73_RS05560	COG1215	transferase activity, transferring glycosyl groups
HEP73_RS05590	COG4993	Dehydrogenase
HEP73_RS05595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP73_RS05595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP73_RS05605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP73_RS05615	COG1174	glycine betaine transport
HEP73_RS05620	COG1125	glycine betaine transport
HEP73_RS05630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP73_RS05635	COG0564	pseudouridine synthase activity
HEP73_RS05655	COG0840	transmembrane signaling receptor activity
HEP73_RS05660	COG4993	Dehydrogenase
HEP73_RS05670	COG3387	PFAM Glycoside hydrolase 15-related
HEP73_RS05690	COG0454	-acetyltransferase
HEP73_RS05715	COG0542	response to heat
HEP73_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS05745	COG1733	regulation of RNA biosynthetic process
HEP73_RS05755	COG2223	nitrite transmembrane transporter activity
HEP73_RS05765	COG0019	diaminopimelate decarboxylase activity
HEP73_RS05770	COG4264	IucA IucC family
HEP73_RS05775	COG2814	Major facilitator Superfamily
HEP73_RS05780	COG4264	IucA IucC family
HEP73_RS05790	COG4772	TonB-dependent receptor
HEP73_RS05800	COG4651	solute:proton antiporter activity
HEP73_RS05800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP73_RS05855	COG0488	(ABC) transporter
HEP73_RS05890	COG0657	acetylesterase activity
HEP73_RS05890	COG2755	lipolytic protein G-D-S-L family
HEP73_RS05900	COG4774	siderophore transport
HEP73_RS05945	COG0217	transcriptional regulatory protein
HEP73_RS05955	COG0632	four-way junction helicase activity
HEP73_RS05970	COG0824	Thioesterase
HEP73_RS05980	COG0848	biopolymer transport protein
HEP73_RS05990	COG0823	Involved in the tonB-independent uptake of proteins
HEP73_RS05995	COG2885	chlorophyll binding
HEP73_RS06005	COG0602	queuosine metabolic process
HEP73_RS06010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEP73_RS06045	COG0514	ATP-dependent DNA helicase (RecQ)
HEP73_RS06055	COG0783	Belongs to the Dps family
HEP73_RS06060	COG1643	Atp-dependent helicase
HEP73_RS06100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP73_RS06110	COG1216	Glycosyl transferase, family 2
HEP73_RS06115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP73_RS06125	COG1199	ATP-dependent helicase activity
HEP73_RS06135	COG1397	ADP-ribosylglycohydrolase
HEP73_RS06150	COG0189	ligase activity
HEP73_RS06165	COG0835	chemotaxis
HEP73_RS06170	COG0840	transmembrane signaling receptor activity
HEP73_RS06175	COG2198	Histidine kinase
HEP73_RS06175	COG0784	Response regulator, receiver
HEP73_RS06175	COG0643	Histidine kinase
HEP73_RS06180	COG2201	protein-glutamate methylesterase activity
HEP73_RS06230	COG1446	asparaginase
HEP73_RS06305	COG3279	Response regulator of the LytR AlgR family
HEP73_RS06310	COG3275	phosphorelay sensor kinase activity
HEP73_RS06315	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HEP73_RS06335	COG0583	DNA-binding transcription factor activity
HEP73_RS06355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP73_RS06445	COG3537	Alpha-1,2-mannosidase
HEP73_RS06455	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP73_RS06465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP73_RS06470	COG1388	LysM domain
HEP73_RS06470	COG3858	chitin binding
HEP73_RS06485	COG0837	glucose binding
HEP73_RS06495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEP73_RS06505	COG0494	nUDIX hydrolase
HEP73_RS06515	COG3956	TIGRFAM MazG family protein
HEP73_RS06530	COG0330	HflC and HflK could
HEP73_RS06565	COG0697	spore germination
HEP73_RS06590	COG1960	acyl-CoA dehydrogenase activity
HEP73_RS06620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEP73_RS06625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP73_RS06630	COG0463	Glycosyl transferase, family 2
HEP73_RS06635	COG0517	IMP dehydrogenase activity
HEP73_RS06640	COG2982	Protein involved in outer membrane biogenesis
HEP73_RS06645	COG1272	protein, Hemolysin III
HEP73_RS06650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEP73_RS06660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP73_RS06665	COG0626	cystathionine gamma-synthase activity
HEP73_RS06670	COG0527	aspartate kinase activity
HEP73_RS06670	COG0460	homoserine dehydrogenase
HEP73_RS06685	COG1760	l-serine dehydratase
HEP73_RS06700	COG3038	cytochrome b561
HEP73_RS06720	COG0477	Major facilitator Superfamily
HEP73_RS06725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP73_RS06740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP73_RS06810	COG3706	GGDEF domain
HEP73_RS06850	COG0519	Catalyzes the synthesis of GMP from XMP
HEP73_RS06865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP73_RS06910	COG1113	amino acid transport
HEP73_RS06930	COG2239	Acts as a magnesium transporter
HEP73_RS06935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP73_RS06940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP73_RS06950	COG1660	Displays ATPase and GTPase activities
HEP73_RS06960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP73_RS06975	COG1137	ATPase activity
HEP73_RS06990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEP73_RS07025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEP73_RS07050	COG0628	permease
HEP73_RS07060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP73_RS07065	COG3178	'Phosphotransferase
HEP73_RS07080	COG1555	photosystem II stabilization
HEP73_RS07100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_RS07105	COG1477	protein flavinylation
HEP73_RS07130	COG4774	siderophore transport
HEP73_RS07135	COG2146	nitrite reductase [NAD(P)H] activity
HEP73_RS07145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP73_RS07150	COG0719	Fe-S assembly protein
HEP73_RS07155	COG0396	ATPase activity
HEP73_RS07160	COG0719	Fe-S assembly protein
HEP73_RS07175	COG0693	protein deglycase activity
HEP73_RS07190	COG0739	heme binding
HEP73_RS07205	COG1764	response to oxidative stress
HEP73_RS07215	COG0384	phenazine biosynthesis protein PhzF
HEP73_RS07220	COG0527	aspartate kinase activity
HEP73_RS07245	COG0142	geranyltranstransferase activity
HEP73_RS07250	COG0629	single-stranded DNA binding
HEP73_RS07275	COG2010	Cytochrome c
HEP73_RS07285	COG0673	inositol 2-dehydrogenase activity
HEP73_RS07290	COG2211	Major facilitator Superfamily
HEP73_RS07300	COG1609	Transcriptional regulator
HEP73_RS07325	COG3104	oligopeptide transport
HEP73_RS07330	COG1297	OPT oligopeptide transporter protein
HEP73_RS07335	COG1506	peptidase
HEP73_RS07335	COG0823	Involved in the tonB-independent uptake of proteins
HEP73_RS07355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP73_RS07360	COG2879	small protein
HEP73_RS07365	COG1966	Carbon starvation protein
HEP73_RS07370	COG1741	Belongs to the pirin family
HEP73_RS07380	COG1741	Belongs to the pirin family
HEP73_RS07390	COG1515	deoxyribonuclease V activity
HEP73_RS07410	COG2211	Major facilitator Superfamily
HEP73_RS07420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_RS07435	COG5001	Diguanylate cyclase
HEP73_RS07435	COG2203	Gaf domain
HEP73_RS07435	COG3706	GGDEF domain
HEP73_RS07435	COG4251	negative regulation of phosphorylation
HEP73_RS07440	COG0835	chemotaxis
HEP73_RS07445	COG0840	transmembrane signaling receptor activity
HEP73_RS07455	COG0840	transmembrane signaling receptor activity
HEP73_RS07460	COG0643	Histidine kinase
HEP73_RS07460	COG2198	Histidine kinase
HEP73_RS07470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEP73_RS07485	COG3878	Protein conserved in bacteria
HEP73_RS07490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEP73_RS07500	COG0642	Histidine kinase
HEP73_RS07505	COG3111	PFAM Bacterial OB fold (BOF) protein
HEP73_RS07510	COG0745	RESPONSE REGULATOR receiver
HEP73_RS07515	COG2205	protein histidine kinase activity
HEP73_RS07525	COG4452	Inner membrane protein CreD
HEP73_RS07550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP73_RS07555	COG0735	belongs to the Fur family
HEP73_RS07605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_RS07615	COG1309	transcriptional regulator
HEP73_RS07630	COG3214	Protein conserved in bacteria
HEP73_RS07650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP73_RS07655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP73_RS07660	COG2080	2 iron, 2 sulfur cluster binding
HEP73_RS07695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP73_RS07760	COG1187	pseudouridine synthase activity
HEP73_RS07785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP73_RS07790	COG3795	YCII-related domain
HEP73_RS07810	COG4941	Belongs to the sigma-70 factor family
HEP73_RS07835	COG1132	(ABC) transporter
HEP73_RS07870	COG0583	DNA-binding transcription factor activity
HEP73_RS07915	COG1981	membrane
HEP73_RS07925	COG0825	malonyl-CoA metabolic process
HEP73_RS07945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP73_RS07965	COG0750	zinc metalloprotease
HEP73_RS07970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP73_RS07975	COG0575	Belongs to the CDS family
HEP73_RS07980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP73_RS07990	COG0528	UMP kinase activity
HEP73_RS08000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP73_RS08040	COG0024	Methionine aminopeptidase
HEP73_RS08055	COG1393	Belongs to the ArsC family
HEP73_RS08060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP73_RS08065	COG0367	asparagine synthase
HEP73_RS08115	COG1566	PFAM secretion protein HlyD family protein
HEP73_RS08120	COG2814	Major facilitator Superfamily
HEP73_RS08160	COG0557	exoribonuclease II activity
HEP73_RS08170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP73_RS08190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP73_RS08210	COG0704	Plays a role in the regulation of phosphate uptake
HEP73_RS08220	COG0581	inorganic phosphate transmembrane transporter activity
HEP73_RS08235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP73_RS08255	COG0659	secondary active sulfate transmembrane transporter activity
HEP73_RS08260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEP73_RS08270	COG1024	Enoyl-CoA hydratase
HEP73_RS08315	COG0488	(ABC) transporter
HEP73_RS08330	COG5002	protein histidine kinase activity
HEP73_RS08330	COG2205	protein histidine kinase activity
HEP73_RS08330	COG0784	Response regulator, receiver
HEP73_RS08335	COG2733	membrane
HEP73_RS08385	COG0686	Belongs to the AlaDH PNT family
HEP73_RS08390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP73_RS08395	COG1917	Cupin 2, conserved barrel domain protein
HEP73_RS08395	COG1396	sequence-specific DNA binding
HEP73_RS08400	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_RS08420	COG0243	molybdopterin cofactor binding
HEP73_RS08430	COG0477	Major facilitator Superfamily
HEP73_RS08440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_RS08445	COG0174	glutamine synthetase
HEP73_RS08450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP73_RS08455	COG0174	glutamine synthetase
HEP73_RS08475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP73_RS08480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP73_RS08490	COG0501	Belongs to the peptidase M48B family
HEP73_RS08515	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HEP73_RS08580	COG3842	ATPase activity
HEP73_RS08585	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP73_RS08590	COG1177	transmembrane transport
HEP73_RS08595	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_RS08600	COG0598	Magnesium transport protein CorA
HEP73_RS08610	COG4535	Mg2 and Co2 transporter CorC
HEP73_RS08640	COG1702	phosphate starvation-inducible protein PhoH
HEP73_RS08655	COG0625	glutathione transferase activity
HEP73_RS08665	COG0741	lytic transglycosylase activity
HEP73_RS08670	COG0723	plastoquinol--plastocyanin reductase activity
HEP73_RS08675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP73_RS08685	COG2857	Cytochrome c1
HEP73_RS08690	COG0625	glutathione transferase activity
HEP73_RS08695	COG2969	positive regulation of protein catabolic process
HEP73_RS08735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP73_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS08745	COG2095	MarC family integral membrane protein
HEP73_RS08760	COG1611	Belongs to the LOG family
HEP73_RS08805	COG0556	nucleotide-excision repair
HEP73_RS08840	COG2948	multi-organism process
HEP73_RS08890	COG0366	Alpha amylase catalytic
HEP73_RS08900	COG1082	Xylose isomerase domain protein TIM barrel
HEP73_RS08945	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP73_RS08955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP73_RS08960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP73_RS08965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP73_RS08965	COG0072	phenylalanine-tRNA ligase activity
HEP73_RS09010	COG0438	transferase activity, transferring glycosyl groups
HEP73_RS09025	COG0438	transferase activity, transferring glycosyl groups
HEP73_RS09050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP73_RS09060	COG1960	acyl-CoA dehydrogenase activity
HEP73_RS09080	COG1846	Transcriptional regulator
HEP73_RS09110	COG1570	exodeoxyribonuclease VII activity
HEP73_RS09115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEP73_RS09120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEP73_RS09120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP73_RS09125	COG0802	atpase or kinase
HEP73_RS09130	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP73_RS09135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP73_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS09180	COG2081	HI0933 family
HEP73_RS09185	COG4681	YaeQ
HEP73_RS09190	COG0564	pseudouridine synthase activity
HEP73_RS09200	COG0625	glutathione transferase activity
HEP73_RS09205	COG0657	acetylesterase activity
HEP73_RS09240	COG0513	Belongs to the DEAD box helicase family
HEP73_RS09245	COG0488	(ABC) transporter
HEP73_RS09260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP73_RS09265	COG2207	Transcriptional regulator
HEP73_RS09280	COG2197	response regulator
HEP73_RS09325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP73_RS09330	COG1846	Transcriptional regulator
HEP73_RS09335	COG0339	signal peptide processing
HEP73_RS09340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP73_RS09345	COG0386	Belongs to the glutathione peroxidase family
HEP73_RS09375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP73_RS09420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEP73_RS09450	COG0084	hydrolase, TatD family'
HEP73_RS09465	COG1960	acyl-CoA dehydrogenase activity
HEP73_RS09480	COG0305	Participates in initiation and elongation during chromosome replication
HEP73_RS09495	COG2204	response regulator
HEP73_RS09505	COG0415	Belongs to the DNA photolyase family
HEP73_RS09520	COG0583	DNA-binding transcription factor activity
HEP73_RS09535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS09560	COG3706	GGDEF domain
HEP73_RS09565	COG0583	DNA-binding transcription factor activity
HEP73_RS09585	COG1404	Belongs to the peptidase S8 family
HEP73_RS09590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP73_RS09605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP73_RS09610	COG0735	belongs to the Fur family
HEP73_RS09615	COG0497	DNA recombination
HEP73_RS09620	COG1420	regulation of RNA biosynthetic process
HEP73_RS09625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP73_RS09630	COG0443	Heat shock 70 kDa protein
HEP73_RS09635	COG0484	heat shock protein binding
HEP73_RS09650	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HEP73_RS09655	COG1605	Chorismate mutase
HEP73_RS09655	COG0287	Prephenate dehydrogenase
HEP73_RS09665	COG1132	(ABC) transporter
HEP73_RS09715	COG2850	peptidyl-arginine hydroxylation
HEP73_RS09720	COG2885	chlorophyll binding
HEP73_RS09765	COG1131	(ABC) transporter
HEP73_RS09770	COG1725	Transcriptional regulator
HEP73_RS09780	COG0386	Belongs to the glutathione peroxidase family
HEP73_RS09795	COG2900	Belongs to the SlyX family
HEP73_RS09805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP73_RS09805	COG2755	lipolytic protein G-D-S-L family
HEP73_RS09815	COG1410	methionine synthase
HEP73_RS09815	COG0646	methionine synthase
HEP73_RS09820	COG0646	methionine synthase
HEP73_RS09820	COG1410	methionine synthase
HEP73_RS09825	COG2226	methyltransferase
HEP73_RS09830	COG1960	acyl-CoA dehydrogenase activity
HEP73_RS09835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_RS09840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS09850	COG2902	Dehydrogenase
HEP73_RS09885	COG2925	Exonuclease
HEP73_RS09895	COG3844	kynureninase activity
HEP73_RS09910	COG0288	reversible hydration of carbon dioxide
HEP73_RS09985	COG0316	Belongs to the HesB IscA family
HEP73_RS09990	COG2977	Belongs to the P-Pant transferase superfamily
HEP73_RS10020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP73_RS10030	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HEP73_RS10050	COG4993	Dehydrogenase
HEP73_RS10100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP73_RS10130	COG4221	oxidoreductase activity
HEP73_RS10165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HEP73_RS10170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP73_RS10175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP73_RS10180	COG1605	Chorismate mutase
HEP73_RS10180	COG0077	Prephenate dehydratase
HEP73_RS10200	COG0583	DNA-binding transcription factor activity
HEP73_RS10235	COG1530	ribonuclease E activity
HEP73_RS10245	COG3064	Membrane
HEP73_RS10250	COG0428	transporter
HEP73_RS10265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEP73_RS10265	COG0316	Belongs to the HesB IscA family
HEP73_RS10285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS10305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP73_RS10310	COG2957	Belongs to the agmatine deiminase family
HEP73_RS10325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP73_RS10330	COG0539	negative regulation of cytoplasmic translation
HEP73_RS10335	COG0776	regulation of translation
HEP73_RS10345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEP73_RS10350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP73_RS10360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP73_RS10365	COG0183	Belongs to the thiolase family
HEP73_RS10370	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP73_RS10370	COG1024	Enoyl-CoA hydratase
HEP73_RS10385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP73_RS10395	COG1426	Protein conserved in bacteria
HEP73_RS10405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP73_RS10415	COG0746	molybdenum cofactor guanylyltransferase activity
HEP73_RS10425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP73_RS10430	COG0475	glutathione-regulated potassium exporter activity
HEP73_RS10430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP73_RS10445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP73_RS10455	COG0519	Catalyzes the synthesis of GMP from XMP
HEP73_RS10455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP73_RS10475	COG0084	hydrolase, TatD family'
HEP73_RS10495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP73_RS10510	COG2963	transposase activity
HEP73_RS10540	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP73_RS10545	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP73_RS10550	COG4191	Histidine kinase
HEP73_RS10550	COG0784	Response regulator, receiver
HEP73_RS10560	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEP73_RS10570	COG1914	H( )-stimulated, divalent metal cation uptake system
HEP73_RS10585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP73_RS10590	COG0668	transmembrane transport
HEP73_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS10620	COG1183	phosphatidylcholine synthase activity
HEP73_RS10630	COG3243	poly(R)-hydroxyalkanoic acid synthase
HEP73_RS10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_RS10650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEP73_RS10660	COG4191	Histidine kinase
HEP73_RS10660	COG0784	Response regulator, receiver
HEP73_RS10665	COG2183	response to ionizing radiation
HEP73_RS10670	COG2205	protein histidine kinase activity
HEP73_RS10670	COG0784	Response regulator, receiver
HEP73_RS10875	COG0305	Participates in initiation and elongation during chromosome replication
HEP73_RS11155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS11175	COG5002	protein histidine kinase activity
HEP73_RS11175	COG5000	phosphorelay sensor kinase activity
HEP73_RS11185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS11230	COG2197	response regulator
HEP73_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS11245	COG4585	Histidine kinase
HEP73_RS11260	COG0714	Associated with various cellular activities
HEP73_RS11270	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP73_RS11290	COG1136	(ABC) transporter
HEP73_RS11290	COG0577	efflux transmembrane transporter activity
HEP73_RS11350	COG1132	(ABC) transporter
HEP73_RS11370	COG0438	transferase activity, transferring glycosyl groups
HEP73_RS11375	COG0297	glycogen (starch) synthase activity
HEP73_RS11395	COG2226	methyltransferase
HEP73_RS11415	COG2244	polysaccharide biosynthetic process
HEP73_RS11445	COG3038	cytochrome b561
HEP73_RS11465	COG1595	DNA-templated transcription, initiation
HEP73_RS11500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP73_RS11540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP73_RS11545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEP73_RS11550	COG1230	cation diffusion facilitator family transporter
HEP73_RS11565	COG1674	ftsk spoiiie
HEP73_RS11570	COG0492	ferredoxin-NADP+ reductase activity
HEP73_RS11590	COG0542	response to heat
HEP73_RS11610	COG0482	sulfurtransferase activity
HEP73_RS11615	COG2915	High frequency lysogenization protein hflD homolog
HEP73_RS11630	COG1116	anion transmembrane transporter activity
HEP73_RS11680	COG0835	chemotaxis
HEP73_RS11680	COG0784	Response regulator, receiver
HEP73_RS11690	COG1558	bacterial-type flagellum-dependent cell motility
HEP73_RS11695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HEP73_RS11700	COG1749	Flagellar hook protein flgE
HEP73_RS11715	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HEP73_RS11730	COG1256	bacterial-type flagellum assembly
HEP73_RS11730	COG4786	Flagellar basal body rod
HEP73_RS11735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HEP73_RS11745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HEP73_RS11765	COG2197	response regulator
HEP73_RS11775	COG2201	protein-glutamate methylesterase activity
HEP73_RS11795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS11860	COG1677	Flagellar hook-basal body complex protein FliE
HEP73_RS11910	COG3190	flagellar
HEP73_RS11920	COG1987	bacterial-type flagellum assembly
HEP73_RS11925	COG1684	flagellar biosynthetic protein fliR
HEP73_RS11975	COG2198	Histidine kinase
HEP73_RS11975	COG0784	Response regulator, receiver
HEP73_RS11975	COG0643	Histidine kinase
HEP73_RS11980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HEP73_RS11985	COG1360	Flagellar Motor Protein
HEP73_RS11990	COG1192	Involved in chromosome partitioning
HEP73_RS12005	COG0745	RESPONSE REGULATOR receiver
HEP73_RS12015	COG0840	transmembrane signaling receptor activity
HEP73_RS12020	COG0840	transmembrane signaling receptor activity
HEP73_RS12025	COG0840	transmembrane signaling receptor activity
HEP73_RS12035	COG0840	transmembrane signaling receptor activity
HEP73_RS12040	COG0840	transmembrane signaling receptor activity
HEP73_RS12045	COG0840	transmembrane signaling receptor activity
HEP73_RS12050	COG0840	transmembrane signaling receptor activity
HEP73_RS12060	COG0840	transmembrane signaling receptor activity
HEP73_RS12065	COG0840	transmembrane signaling receptor activity
HEP73_RS12075	COG0835	chemotaxis
HEP73_RS12085	COG0840	transmembrane signaling receptor activity
HEP73_RS12155	COG0318	PFAM AMP-dependent synthetase and ligase
HEP73_RS12160	COG1024	Enoyl-CoA hydratase
HEP73_RS12165	COG2205	protein histidine kinase activity
HEP73_RS12165	COG0784	Response regulator, receiver
HEP73_RS12165	COG2198	Histidine kinase
HEP73_RS12185	COG3279	Response regulator of the LytR AlgR family
HEP73_RS12190	COG4676	Protein conserved in bacteria
HEP73_RS12205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP73_RS12210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP73_RS12220	COG0505	Belongs to the CarA family
HEP73_RS12230	COG2258	MOSC domain
HEP73_RS12235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP73_RS12270	COG1024	Enoyl-CoA hydratase
HEP73_RS12290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP73_RS12310	COG0277	FAD linked oxidase domain protein
HEP73_RS12315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP73_RS12330	COG0531	amino acid
HEP73_RS12335	COG0531	amino acid
HEP73_RS12340	COG0235	Class ii aldolase
HEP73_RS12345	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP73_RS12350	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP73_RS12365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP73_RS12365	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP73_RS12380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP73_RS12395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP73_RS12400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP73_RS12415	COG0124	histidyl-tRNA synthetase
HEP73_RS12420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP73_RS12430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP73_RS12435	COG0083	homoserine kinase activity
HEP73_RS12440	COG0460	homoserine dehydrogenase
HEP73_RS12440	COG0527	aspartate kinase activity
HEP73_RS12460	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_RS12485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP73_RS12500	COG1794	racemase activity, acting on amino acids and derivatives
HEP73_RS12505	COG0671	phosphoesterase, PA-phosphatase related
HEP73_RS12520	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HEP73_RS12555	COG0166	Belongs to the GPI family
HEP73_RS12570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP73_RS12575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP73_RS12580	COG0617	tRNA 3'-terminal CCA addition
HEP73_RS12590	COG0477	Major facilitator Superfamily
HEP73_RS12595	COG2115	Belongs to the xylose isomerase family
HEP73_RS12600	COG1070	Carbohydrate kinase
HEP73_RS12610	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP73_RS12645	COG0800	Aldolase
HEP73_RS12660	COG3734	2-keto-3-deoxy-galactonokinase
HEP73_RS12665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEP73_RS12675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP73_RS12685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEP73_RS12690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP73_RS12705	COG0351	phosphomethylpyrimidine kinase
HEP73_RS12705	COG0352	thiamine-phosphate diphosphorylase activity
HEP73_RS12730	COG0583	DNA-binding transcription factor activity
HEP73_RS12735	COG1741	Belongs to the pirin family
HEP73_RS12750	COG0194	GDP metabolic process
HEP73_RS12765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEP73_RS12770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP73_RS12775	COG2137	regulation of response to DNA damage stimulus
HEP73_RS12780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP73_RS12785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP73_RS12790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP73_RS12795	COG1546	Belongs to the CinA family
HEP73_RS12805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP73_RS12815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEP73_RS12820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP73_RS12825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP73_RS12830	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HEP73_RS12835	COG1534	Rna-binding protein
HEP73_RS12850	COG1238	metal cluster binding
HEP73_RS12860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEP73_RS12875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP73_RS12880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP73_RS12885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HEP73_RS12905	COG0504	CTP synthase activity
HEP73_RS12940	COG0306	phosphate transporter
HEP73_RS12950	COG1253	flavin adenine dinucleotide binding
HEP73_RS12965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP73_RS13000	COG0069	glutamate synthase activity
HEP73_RS13005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP73_RS13020	COG1609	Transcriptional regulator
HEP73_RS13025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP73_RS13025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP73_RS13030	COG1105	Belongs to the carbohydrate kinase PfkB family
HEP73_RS13035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP73_RS13035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP73_RS13070	COG0577	efflux transmembrane transporter activity
HEP73_RS13070	COG1136	(ABC) transporter
HEP73_RS13115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP73_RS13125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP73_RS13130	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HEP73_RS13140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP73_RS13150	COG0348	domain, Protein
HEP73_RS13195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP73_RS13210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP73_RS13225	COG1663	tetraacyldisaccharide 4'-kinase activity
HEP73_RS13230	COG1132	(ABC) transporter
HEP73_RS13240	COG0811	peptide transport
HEP73_RS13245	COG2333	competence protein COMEC
HEP73_RS13245	COG0658	competence protein
HEP73_RS13260	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP73_RS13285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEP73_RS13305	COG3842	ATPase activity
HEP73_RS13310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP73_RS13325	COG0129	dihydroxy-acid dehydratase activity
HEP73_RS13330	COG0800	Aldolase
HEP73_RS13340	COG0395	ABC-type sugar transport system, permease component
HEP73_RS13380	COG2350	Protein conserved in bacteria
HEP73_RS13385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEP73_RS13390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP73_RS13395	COG1187	pseudouridine synthase activity
HEP73_RS13420	COG0436	Aminotransferase
HEP73_RS13425	COG4133	protoheme IX ABC transporter activity
HEP73_RS13445	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HEP73_RS13475	COG1278	Cold shock
HEP73_RS13480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEP73_RS13485	COG4988	ABC transporter
HEP73_RS13495	COG1294	oxidase, subunit
HEP73_RS13520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP73_RS13545	COG0165	Argininosuccinate lyase
HEP73_RS13550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP73_RS13560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP73_RS13565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP73_RS13570	COG0137	argininosuccinate synthase activity
HEP73_RS13575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP73_RS13585	COG0215	cysteine-tRNA ligase activity
HEP73_RS13590	COG2166	iron-sulfur cluster assembly
HEP73_RS13625	COG2010	Cytochrome c
HEP73_RS13625	COG4993	Dehydrogenase
HEP73_RS13660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP73_RS13685	COG4303	Ethanolamine ammonia lyase large subunit
HEP73_RS13690	COG4302	ethanolamine ammonia-lyase activity
HEP73_RS13695	COG4677	pectinesterase activity
HEP73_RS13715	COG0402	S-adenosylhomocysteine deaminase activity
HEP73_RS13720	COG3548	integral membrane protein
HEP73_RS13730	COG1509	lysine 2,3-aminomutase activity
HEP73_RS13770	COG1862	Preprotein translocase
HEP73_RS13785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP73_RS13795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP73_RS13805	COG2755	lipolytic protein G-D-S-L family
HEP73_RS13805	COG0657	acetylesterase activity
HEP73_RS13810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP73_RS13830	COG3291	Pkd domain containing protein
HEP73_RS13835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP73_RS13840	COG0405	Gamma-glutamyltransferase
HEP73_RS13845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEP73_RS13860	COG0742	ribosomal rna small subunit methyltransferase
HEP73_RS13880	COG3345	alpha-galactosidase
HEP73_RS13890	COG4771	TonB-dependent receptor
HEP73_RS13905	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP73_RS13940	COG0531	amino acid
HEP73_RS13955	COG0006	proline dipeptidase activity
HEP73_RS13965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP73_RS13980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_RS13985	COG3938	Belongs to the proline racemase family
HEP73_RS13995	COG0552	protein localization to endoplasmic reticulum
HEP73_RS14015	COG2304	oxidoreductase activity
HEP73_RS14050	COG0835	chemotaxis
HEP73_RS14055	COG0840	transmembrane signaling receptor activity
HEP73_RS14055	COG3290	protein histidine kinase activity
HEP73_RS14060	COG1201	RNA secondary structure unwinding
HEP73_RS14075	COG3300	MHYT domain
HEP73_RS14075	COG5001	Diguanylate cyclase
HEP73_RS14080	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP73_RS14105	COG0195	Participates in both transcription termination and antitermination
HEP73_RS14120	COG1007	ATP synthesis coupled electron transport
HEP73_RS14155	COG1034	ATP synthesis coupled electron transport
HEP73_RS14160	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP73_RS14165	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HEP73_RS14170	COG0649	NAD binding
HEP73_RS14175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP73_RS14185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP73_RS14200	COG0149	triose-phosphate isomerase activity
HEP73_RS14205	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS14220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP73_RS14270	COG0101	tRNA pseudouridine synthase activity
HEP73_RS14285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEP73_RS14300	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP73_RS14310	COG0688	phosphatidylethanolamine metabolic process
HEP73_RS14315	COG0741	lytic transglycosylase activity
HEP73_RS14320	COG0433	COG0433 Predicted ATPase
HEP73_RS14325	COG0494	nUDIX hydrolase
HEP73_RS14340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP73_RS14370	COG0717	Belongs to the dCTP deaminase family
HEP73_RS14375	COG0489	protein tyrosine kinase activity
HEP73_RS14385	COG4771	TonB-dependent receptor
HEP73_RS14395	COG3590	peptidase
HEP73_RS14405	COG0705	Rhomboid family
HEP73_RS14425	COG2311	Membrane
HEP73_RS14430	COG1047	Peptidyl-prolyl cis-trans
HEP73_RS14435	COG0791	NLP P60 protein
HEP73_RS14440	COG0791	NLP P60 protein
HEP73_RS14445	COG1607	acyl-coa hydrolase
HEP73_RS14450	COG4106	trans-aconitate 2-methyltransferase activity
HEP73_RS14455	COG1301	dicarboxylic acid transport
HEP73_RS14460	COG1785	Belongs to the alkaline phosphatase family
HEP73_RS14470	COG0037	tRNA processing
HEP73_RS14475	COG1722	exodeoxyribonuclease VII activity
HEP73_RS14480	COG0142	geranyltranstransferase activity
HEP73_RS14490	COG4104	PAAR repeat-containing protein
HEP73_RS14525	COG0312	modulator of DNA gyrase
HEP73_RS14535	COG0312	modulator of DNA gyrase
HEP73_RS14555	COG2968	Membrane
HEP73_RS14570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEP73_RS14585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP73_RS14600	COG0495	leucyl-tRNA aminoacylation
HEP73_RS14610	COG3118	belongs to the thioredoxin family
HEP73_RS14630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEP73_RS14640	COG2040	homocysteine
HEP73_RS14650	COG0346	lactoylglutathione lyase activity
HEP73_RS14655	COG1131	(ABC) transporter
HEP73_RS14670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP73_RS14670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP73_RS14680	COG2878	Part of a membrane complex involved in electron transport
HEP73_RS14695	COG1595	DNA-templated transcription, initiation
HEP73_RS14720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP73_RS14745	COG0251	oxidation-reduction process
HEP73_RS14755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP73_RS14755	COG0392	lysyltransferase activity
HEP73_RS14795	COG2814	Major facilitator Superfamily
HEP73_RS14800	COG1902	pentaerythritol trinitrate reductase activity
HEP73_RS14805	COG0583	DNA-binding transcription factor activity
HEP73_RS14820	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP73_RS14830	COG1047	Peptidyl-prolyl cis-trans
HEP73_RS14835	COG1077	Cell shape determining protein MreB Mrl
HEP73_RS14870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEP73_RS14880	COG1451	nucleotide metabolic process
HEP73_RS14900	COG2205	protein histidine kinase activity
HEP73_RS14910	COG2186	Transcriptional regulator
HEP73_RS14915	COG3250	beta-galactosidase activity
HEP73_RS14975	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP73_RS14975	COG1703	isobutyryl-CoA mutase activity
HEP73_RS14975	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP73_RS15000	COG0183	Belongs to the thiolase family
HEP73_RS15010	COG0443	Heat shock 70 kDa protein
HEP73_RS15040	COG1960	acyl-CoA dehydrogenase activity
HEP73_RS15045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP73_RS15045	COG1793	dna ligase
HEP73_RS15050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP73_RS15050	COG1793	dna ligase
HEP73_RS15055	COG1201	RNA secondary structure unwinding
HEP73_RS15065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP73_RS15070	COG1278	Cold shock
HEP73_RS15075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP73_RS15080	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEP73_RS15085	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP73_RS15090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP73_RS15095	COG2954	triphosphatase activity
HEP73_RS15105	COG0745	RESPONSE REGULATOR receiver
HEP73_RS15110	COG1381	Involved in DNA repair and RecF pathway recombination
HEP73_RS15115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP73_RS15130	COG0681	Belongs to the peptidase S26 family
HEP73_RS15135	COG0481	GTPase activity
HEP73_RS15140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP73_RS15155	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP73_RS15155	COG1024	Enoyl-CoA hydratase
HEP73_RS15185	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS15190	COG2855	membrane
HEP73_RS15205	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HEP73_RS15210	COG3250	beta-galactosidase activity
HEP73_RS15215	COG3540	Alkaline phosphatase
HEP73_RS15240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEP73_RS15255	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HEP73_RS15275	COG0534	Mate efflux family protein
HEP73_RS15280	COG0335	large ribosomal subunit rRNA binding
HEP73_RS15285	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP73_RS15290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP73_RS15295	COG0228	four-way junction DNA binding
HEP73_RS15305	COG2070	2-Nitropropane dioxygenase
HEP73_RS15310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEP73_RS15335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP73_RS15355	COG0475	glutathione-regulated potassium exporter activity
HEP73_RS15375	COG0625	glutathione transferase activity
HEP73_RS15380	COG1082	Xylose isomerase domain protein TIM barrel
HEP73_RS15390	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP73_RS15395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP73_RS15400	COG1129	ABC transporter
HEP73_RS15405	COG1879	ABC-type sugar transport system periplasmic component
HEP73_RS15410	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS15430	COG0129	dihydroxy-acid dehydratase activity
HEP73_RS15465	COG3152	Membrane
HEP73_RS15495	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS15495	COG0604	alcohol dehydrogenase
HEP73_RS15495	COG3321	synthase
HEP73_RS15510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEP73_RS15515	COG1845	cytochrome c oxidase, subunit III
HEP73_RS15520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP73_RS15530	COG2964	Protein conserved in bacteria
HEP73_RS15545	COG4771	TonB-dependent receptor
HEP73_RS15570	COG0251	oxidation-reduction process
HEP73_RS15605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP73_RS15620	COG0196	riboflavin kinase activity
HEP73_RS15625	COG0728	peptidoglycan biosynthetic process
HEP73_RS15635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP73_RS15640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP73_RS15645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP73_RS15650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP73_RS15655	COG0824	Thioesterase
HEP73_RS15665	COG1024	Enoyl-CoA hydratase
HEP73_RS15665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP73_RS15670	COG1946	Acyl-CoA thioesterase
HEP73_RS15685	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HEP73_RS15700	COG0840	transmembrane signaling receptor activity
HEP73_RS15720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HEP73_RS15740	COG1073	alpha beta
HEP73_RS15770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEP73_RS15795	COG4585	Histidine kinase
HEP73_RS15810	COG2894	cell division
HEP73_RS15815	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEP73_RS15825	COG2205	protein histidine kinase activity
HEP73_RS15830	COG0745	RESPONSE REGULATOR receiver
HEP73_RS15840	COG2194	sulfuric ester hydrolase activity
HEP73_RS15860	COG2814	Major facilitator Superfamily
HEP73_RS15865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP73_RS15865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP73_RS15875	COG5001	Diguanylate cyclase
HEP73_RS15875	COG2203	Gaf domain
HEP73_RS15875	COG4251	negative regulation of phosphorylation
HEP73_RS15875	COG3706	GGDEF domain
HEP73_RS15880	COG0753	catalase activity
HEP73_RS15905	COG1063	alcohol dehydrogenase
HEP73_RS15915	COG3459	Glycosyltransferase 36 associated
HEP73_RS15920	COG2186	Transcriptional regulator
HEP73_RS15940	COG2271	Major facilitator Superfamily
HEP73_RS15945	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS15980	COG1064	alcohol dehydrogenase
HEP73_RS16000	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS16015	COG0492	ferredoxin-NADP+ reductase activity
HEP73_RS16050	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS16055	COG3387	PFAM Glycoside hydrolase 15-related
HEP73_RS16065	COG3275	phosphorelay sensor kinase activity
HEP73_RS16105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HEP73_RS16165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP73_RS16175	COG0330	HflC and HflK could
HEP73_RS16180	COG0330	HflC and HflK could
HEP73_RS16185	COG0604	alcohol dehydrogenase
HEP73_RS16205	COG0678	peroxiredoxin activity
HEP73_RS16215	COG4953	penicillin-binding protein 1C
HEP73_RS16220	COG1349	DNA-binding transcription factor activity
HEP73_RS16230	COG2223	nitrite transmembrane transporter activity
HEP73_RS16260	COG1136	(ABC) transporter
HEP73_RS16260	COG0577	efflux transmembrane transporter activity
HEP73_RS16280	COG2373	Large extracellular alpha-helical protein
HEP73_RS16330	COG0372	Belongs to the citrate synthase family
HEP73_RS16345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP73_RS16395	COG2161	toxin-antitoxin pair type II binding
HEP73_RS16400	COG4115	mRNA cleavage
HEP73_RS16420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP73_RS16425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP73_RS16430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP73_RS16440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP73_RS16445	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS16450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEP73_RS16455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_RS16465	COG1399	metal-binding, possibly nucleic acid-binding protein
HEP73_RS16490	COG0714	Associated with various cellular activities
HEP73_RS16510	COG0537	adenosine 5'-monophosphoramidase activity
HEP73_RS16540	COG0314	molybdopterin synthase activity
HEP73_RS16545	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEP73_RS16550	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP73_RS16560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP73_RS16565	COG1234	tRNA 3'-trailer cleavage
HEP73_RS16575	COG0859	PFAM glycosyl transferase family 9
HEP73_RS16595	COG0631	protein serine/threonine phosphatase activity
HEP73_RS16600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP73_RS16615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP73_RS16620	COG1388	LysM domain
HEP73_RS16620	COG3942	CHAP domain
HEP73_RS16655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP73_RS16665	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP73_RS16710	COG0473	3-isopropylmalate dehydrogenase activity
HEP73_RS16725	COG4783	chaperone-mediated protein folding
HEP73_RS16740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP73_RS16745	COG0248	Ppx GppA phosphatase
HEP73_RS16750	COG0438	transferase activity, transferring glycosyl groups
HEP73_RS16760	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP73_RS16770	COG3291	Pkd domain containing protein
HEP73_RS16775	COG2833	Protein of unknown function (DUF455)
HEP73_RS16795	COG0285	dihydrofolate synthase activity
HEP73_RS16800	COG0588	phosphoglycerate mutase activity
HEP73_RS16820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEP73_RS16825	COG4208	sulfate ABC transporter
HEP73_RS16830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEP73_RS16835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEP73_RS16850	COG1187	pseudouridine synthase activity
HEP73_RS16865	COG2885	chlorophyll binding
HEP73_RS16870	COG0583	DNA-binding transcription factor activity
HEP73_RS16875	COG2814	Major facilitator Superfamily
HEP73_RS16885	COG0667	Aldo Keto reductase
HEP73_RS16895	COG1902	pentaerythritol trinitrate reductase activity
HEP73_RS16895	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP73_RS16940	COG0625	glutathione transferase activity
HEP73_RS16965	COG0039	L-malate dehydrogenase activity
HEP73_RS16975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP73_RS16980	COG1217	gtp-binding protein TYPA
HEP73_RS16990	COG0154	amidase activity
HEP73_RS17010	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP73_RS17020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HEP73_RS17025	COG0203	ribosomal protein L17
HEP73_RS17035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP73_RS17050	COG0201	protein transport
HEP73_RS17060	COG1841	ribosomal large subunit assembly
HEP73_RS17090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP73_RS17095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP73_RS17105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP73_RS17110	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP73_RS17135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP73_RS17140	COG0089	rRNA binding
HEP73_RS17145	COG0088	Forms part of the polypeptide exit tunnel
HEP73_RS17155	COG0051	transcription antitermination factor activity, RNA binding
HEP73_RS17160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP73_RS17165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP73_RS17180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP73_RS17190	COG0222	ribosome binding
HEP73_RS17205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP73_RS17210	COG0250	Participates in transcription elongation, termination and antitermination
HEP73_RS17225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP73_RS17245	COG0012	GTP binding
HEP73_RS17250	COG0193	aminoacyl-tRNA hydrolase activity
HEP73_RS17260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP73_RS17270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP73_RS17285	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP73_RS17290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP73_RS17305	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP73_RS17320	COG1254	Belongs to the acylphosphatase family
HEP73_RS17325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP73_RS17330	COG1295	ribonuclease BN
HEP73_RS17350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP73_RS17355	COG1404	Belongs to the peptidase S8 family
HEP73_RS17360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP73_RS17365	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP73_RS17420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP73_RS17420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP73_RS17425	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS17430	COG0583	DNA-binding transcription factor activity
HEP73_RS17470	COG3634	alkyl hydroperoxide reductase activity
HEP73_RS17475	COG0583	DNA-binding transcription factor activity
HEP73_RS17485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP73_RS17490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP73_RS17510	COG2197	response regulator
HEP73_RS17535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP73_RS17545	COG0697	spore germination
HEP73_RS17595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP73_RS17600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP73_RS17610	COG2096	Adenosyltransferase
HEP73_RS17625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEP73_RS17630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEP73_RS17635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEP73_RS17640	COG2967	ApaG domain
HEP73_RS17645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP73_RS17675	COG1704	LemA family
HEP73_RS17680	COG0861	Integral membrane protein TerC family
HEP73_RS17685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEP73_RS17695	COG0642	Histidine kinase
HEP73_RS17710	COG4181	ATPase activity
HEP73_RS17715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEP73_RS17735	COG4771	TonB-dependent receptor
HEP73_RS17745	COG0667	Aldo Keto reductase
HEP73_RS17750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEP73_RS17770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP73_RS17790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP73_RS17850	COG1349	DNA-binding transcription factor activity
HEP73_RS17875	COG2222	sugar isomerase
HEP73_RS17885	COG3345	alpha-galactosidase
HEP73_RS17900	COG0366	Alpha amylase catalytic
HEP73_RS17905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP73_RS17915	COG0494	nUDIX hydrolase
HEP73_RS17930	COG0739	heme binding
HEP73_RS17940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEP73_RS17945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP73_RS17955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEP73_RS17960	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP73_RS17970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP73_RS17985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEP73_RS18000	COG3116	cell division
HEP73_RS18005	COG0275	rRNA processing
HEP73_RS18010	COG2001	Belongs to the MraZ family
HEP73_RS18035	COG0792	nuclease activity
HEP73_RS18040	COG1988	membrane-bound metal-dependent
HEP73_RS18045	COG0277	FAD linked oxidase domain protein
HEP73_RS18050	COG0745	RESPONSE REGULATOR receiver
HEP73_RS18055	COG2205	protein histidine kinase activity
HEP73_RS18065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP73_RS18070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP73_RS18090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEP73_RS18095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP73_RS18100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP73_RS18120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_RS18120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_RS18130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP73_RS18150	COG0477	Major facilitator Superfamily
HEP73_RS18155	COG0488	(ABC) transporter
HEP73_RS18160	COG0242	peptide deformylase activity
HEP73_RS18170	COG1960	acyl-CoA dehydrogenase activity
HEP73_RS18180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP73_RS18190	COG1696	Membrane protein involved in D-alanine export
HEP73_RS18210	COG1215	transferase activity, transferring glycosyl groups
HEP73_RS18220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEP73_RS18225	COG0457	Tetratricopeptide repeat
HEP73_RS18230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEP73_RS18235	COG1215	transferase activity, transferring glycosyl groups
HEP73_RS18240	COG1215	transferase activity, transferring glycosyl groups
HEP73_RS18300	COG2188	Transcriptional regulator
HEP73_RS18310	COG1450	Type ii and iii secretion system protein
HEP73_RS18325	COG3166	PFAM Fimbrial assembly family protein
HEP73_RS18330	COG3156	type II secretion system protein K
HEP73_RS18335	COG4795	General secretion pathway protein
HEP73_RS18340	COG2165	general secretion pathway protein
HEP73_RS18345	COG4970	Tfp pilus assembly protein FimT
HEP73_RS18350	COG2165	general secretion pathway protein
HEP73_RS18355	COG1459	type II secretion system
HEP73_RS18360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP73_RS18365	COG1404	Belongs to the peptidase S8 family
HEP73_RS18370	COG5295	Hep Hag repeat protein
HEP73_RS18375	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP73_RS18375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP73_RS18380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP73_RS18385	COG4974	Belongs to the 'phage' integrase family
HEP73_RS18410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP73_RS18440	COG1183	phosphatidylcholine synthase activity
HEP73_RS18450	COG0442	prolyl-tRNA aminoacylation
HEP73_RS18465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP73_RS18470	COG1127	ABC transporter
HEP73_RS18475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP73_RS18475	COG3218	ABC-type transport auxiliary lipoprotein component
HEP73_RS18505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HEP73_RS18510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP73_RS18515	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HEP73_RS18515	COG0662	Cupin 2, conserved barrel domain protein
HEP73_RS18540	COG2086	electron transfer activity
HEP73_RS18555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP73_RS18555	COG0546	phosphoglycolate phosphatase activity
HEP73_RS18560	COG0277	FAD linked oxidase domain protein
HEP73_RS18565	COG0300	oxidoreductase activity
HEP73_RS18570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_RS18595	COG0493	'glutamate synthase
HEP73_RS18625	COG1216	Glycosyl transferase, family 2
HEP73_RS18625	COG0438	transferase activity, transferring glycosyl groups
HEP73_RS18630	COG0438	transferase activity, transferring glycosyl groups
HEP73_RS18630	COG1216	Glycosyl transferase, family 2
HEP73_RS18635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEP73_RS18650	COG0626	cystathionine gamma-synthase activity
HEP73_RS18680	COG0625	glutathione transferase activity
HEP73_RS18690	COG0513	Belongs to the DEAD box helicase family
HEP73_RS18695	COG0720	synthase
HEP73_RS18705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP73_RS18710	COG1956	GAF domain-containing protein
HEP73_RS18720	COG4206	TonB-dependent receptor
HEP73_RS18725	COG0546	phosphoglycolate phosphatase activity
HEP73_RS18745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP73_RS18765	COG0339	signal peptide processing
HEP73_RS18770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP73_RS18780	COG2217	Heavy metal translocating P-type atpase
HEP73_RS18795	COG2132	Multicopper oxidase
HEP73_RS18820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP73_RS18830	COG1136	(ABC) transporter
HEP73_RS18835	COG0577	efflux transmembrane transporter activity
HEP73_RS18840	COG0577	efflux transmembrane transporter activity
HEP73_RS18845	COG0577	efflux transmembrane transporter activity
HEP73_RS18850	COG0577	efflux transmembrane transporter activity
HEP73_RS18855	COG1136	(ABC) transporter
HEP73_RS18855	COG0577	efflux transmembrane transporter activity
HEP73_RS18860	COG0577	efflux transmembrane transporter activity
HEP73_RS18860	COG1136	(ABC) transporter
HEP73_RS18865	COG0577	efflux transmembrane transporter activity
HEP73_RS18865	COG1136	(ABC) transporter
HEP73_RS18870	COG1136	(ABC) transporter
HEP73_RS18870	COG0577	efflux transmembrane transporter activity
HEP73_RS18880	COG1136	(ABC) transporter
HEP73_RS18880	COG0577	efflux transmembrane transporter activity
HEP73_RS18895	COG4191	Histidine kinase
HEP73_RS18905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP73_RS18920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP73_RS18935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP73_RS18945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP73_RS18955	COG0356	it plays a direct role in the translocation of protons across the membrane
HEP73_RS18975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP73_RS18980	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP73_RS19015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP73_RS19020	COG0697	spore germination
HEP73_RS19025	COG1666	GTP binding
HEP73_RS19035	COG1187	pseudouridine synthase activity
HEP73_RS19040	COG2813	Specifically methylates the guanine in position
HEP73_RS19060	COG2205	protein histidine kinase activity
HEP73_RS19060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP73_RS19085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_RS19145	COG0842	Transport permease protein
HEP73_RS19150	COG1131	(ABC) transporter
HEP73_RS19155	COG0025	NhaP-type Na H and K H
HEP73_RS19165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEP73_RS19170	COG1573	uracil-dna glycosylase
HEP73_RS19180	COG3384	dioxygenase
HEP73_RS19200	COG0667	Aldo Keto reductase
HEP73_RS19205	COG0667	Aldo Keto reductase
HEP73_RS19220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_RS19225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_RS19230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP73_RS19255	COG5001	Diguanylate cyclase
HEP73_RS19275	COG4106	trans-aconitate 2-methyltransferase activity
HEP73_RS19285	COG2076	Multidrug Resistance protein
HEP73_RS19295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEP73_RS19330	COG3275	phosphorelay sensor kinase activity
HEP73_RS19355	COG0531	amino acid
HEP73_RS19375	COG5297	Belongs to the glycosyl hydrolase family 6
HEP73_RS19375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_RS19380	COG0612	Peptidase, M16
HEP73_RS19405	COG0741	lytic transglycosylase activity
HEP73_RS19430	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP73_RS19435	COG2207	Transcriptional regulator
HEP73_RS19445	COG0598	Magnesium transport protein CorA
HEP73_RS19450	COG1113	amino acid transport
HEP73_RS19460	COG0697	spore germination
HEP73_RS19495	COG2409	Drug exporters of the RND superfamily
HEP73_RS19500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP73_RS19510	COG5520	Belongs to the glycosyl hydrolase 30 family
HEP73_RS19690	COG0584	glycerophosphoryl diester phosphodiesterase
HEP73_RS19715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP73_RS19735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEP73_RS19740	COG4206	TonB-dependent receptor
HEP73_RS19765	COG1595	DNA-templated transcription, initiation
HEP73_RS19770	COG0459	protein refolding
HEP73_RS19780	COG2356	endonuclease I
HEP73_RS19785	COG1324	tolerance protein
HEP73_RS19795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP73_RS19810	COG1733	regulation of RNA biosynthetic process
HEP73_RS19815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP73_RS19820	COG0511	ligase activity, forming carbon-carbon bonds
HEP73_RS19830	COG0439	Biotin carboxylase
HEP73_RS19840	COG0300	oxidoreductase activity
HEP73_RS19855	COG2264	protein methyltransferase activity
HEP73_RS19875	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HEP73_RS19880	COG4589	Belongs to the CDS family
HEP73_RS19905	COG2453	phosphatase
HEP73_RS19905	COG0671	phosphoesterase, PA-phosphatase related
HEP73_RS19910	COG2267	carboxylic ester hydrolase activity
HEP73_RS19915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP73_RS19920	COG0138	bifunctional purine biosynthesis protein purh
HEP73_RS19930	COG0151	Belongs to the GarS family
HEP73_RS19940	COG4771	TonB-dependent receptor
HEP73_RS19950	COG1289	transmembrane transporter activity
HEP73_RS19955	COG2814	Major facilitator Superfamily
HEP73_RS20000	COG2816	NAD+ diphosphatase activity
HEP73_RS20030	COG5002	protein histidine kinase activity
HEP73_RS20030	COG2205	protein histidine kinase activity
HEP73_RS20030	COG0784	Response regulator, receiver
HEP73_RS20070	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HEP73_RS20085	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HEP73_RS20090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP73_RS20095	COG0730	response to heat
HEP73_RS20105	COG0134	indole-3-glycerol-phosphate synthase activity
HEP73_RS20115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP73_RS20145	COG1597	lipid kinase activity
HEP73_RS20160	COG0484	heat shock protein binding
HEP73_RS20190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_RS20195	COG2111	Na H antiporter
HEP73_RS20195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP73_RS20200	COG1006	Multisubunit Na H antiporter MnhC subunit
HEP73_RS20205	COG0651	ATP synthesis coupled electron transport
HEP73_RS20215	COG2212	antiporter activity
HEP73_RS20220	COG1320	monovalent cation:proton antiporter activity
HEP73_RS20245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP73_RS20270	COG3104	oligopeptide transport
HEP73_RS20275	COG3483	tryptophan 2,3-dioxygenase activity
HEP73_RS20285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP73_RS20300	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP73_RS20310	COG3227	Zinc metalloprotease (Elastase)
HEP73_RS20315	COG0513	Belongs to the DEAD box helicase family
HEP73_RS20325	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS20335	COG0702	epimerase
HEP73_RS20340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP73_RS20350	COG2354	Protein conserved in bacteria
HEP73_RS20365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP73_RS20375	COG3264	Mechanosensitive ion channel
HEP73_RS20375	COG1196	nuclear chromosome segregation
HEP73_RS20380	COG3321	synthase
HEP73_RS20380	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS20380	COG0604	alcohol dehydrogenase
HEP73_RS20400	COG1595	DNA-templated transcription, initiation
HEP73_RS20420	COG1802	Transcriptional regulator
HEP73_RS20470	COG1414	Transcriptional regulator
HEP73_RS20475	COG0738	Major facilitator superfamily
HEP73_RS20480	COG3254	rhamnose metabolic process
HEP73_RS20485	COG4948	Mandelate Racemase Muconate Lactonizing
HEP73_RS20490	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP73_RS20495	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS20535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP73_RS20550	COG4807	Protein conserved in bacteria
HEP73_RS20580	COG0708	Exodeoxyribonuclease III
HEP73_RS20605	COG5507	3-demethylubiquinone-9 3-methyltransferase
HEP73_RS20610	COG4773	Receptor
HEP73_RS20640	COG3220	belongs to the UPF0276 family
HEP73_RS20710	COG1192	Involved in chromosome partitioning
HEP73_RS20730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP73_RS20760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP73_RS20765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP73_RS20780	COG0753	catalase activity
HEP73_RS20795	COG4773	Receptor
HEP73_RS20800	COG2197	response regulator
HEP73_RS20805	COG4585	Histidine kinase
HEP73_RS20815	COG1131	(ABC) transporter
HEP73_RS20820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_RS20825	COG1136	(ABC) transporter
HEP73_RS20830	COG0577	efflux transmembrane transporter activity
HEP73_RS20845	COG2962	Rard protein
HEP73_RS20850	COG0697	spore germination
HEP73_RS20855	COG2133	pyrroloquinoline quinone binding
HEP73_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS20870	COG0583	DNA-binding transcription factor activity
HEP73_RS20885	COG0180	Tryptophanyl-tRNA synthetase
HEP73_RS20895	COG3237	CsbD-like
HEP73_RS20925	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEP73_RS20930	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HEP73_RS20930	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HEP73_RS20970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP73_RS21000	COG2084	Dehydrogenase
HEP73_RS21005	COG1902	pentaerythritol trinitrate reductase activity
HEP73_RS21030	COG1404	Belongs to the peptidase S8 family
HEP73_RS21035	COG2814	Major facilitator Superfamily
HEP73_RS21040	COG0583	DNA-binding transcription factor activity
HEP73_RS21060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP73_RS21065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP73_RS21095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP73_RS21105	COG1764	response to oxidative stress
HEP73_RS21110	COG1846	Transcriptional regulator
HEP73_RS21115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEP73_RS21125	COG0697	spore germination
HEP73_RS21130	COG0523	cobalamin synthesis protein
HEP73_RS21145	COG3245	cytochrome
HEP73_RS21155	COG1960	acyl-CoA dehydrogenase activity
HEP73_RS21160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP73_RS21220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP73_RS21225	COG3387	PFAM Glycoside hydrolase 15-related
HEP73_RS21230	COG0745	RESPONSE REGULATOR receiver
HEP73_RS21245	COG1404	Belongs to the peptidase S8 family
HEP73_RS21255	COG3100	YcgL domain-containing protein
HEP73_RS21260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP73_RS21270	COG0463	Glycosyl transferase, family 2
HEP73_RS21295	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_RS21330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP73_RS21345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP73_RS21370	COG1294	oxidase, subunit
HEP73_RS21375	COG1271	oxidase subunit
HEP73_RS21395	COG0408	coproporphyrinogen oxidase activity
HEP73_RS21405	COG2323	membrane
HEP73_RS21450	COG0515	serine threonine protein kinase
HEP73_RS21455	COG0631	protein serine/threonine phosphatase activity
HEP73_RS21510	COG0515	serine threonine protein kinase
HEP73_RS21510	COG2815	serine threonine protein kinase
HEP73_RS21570	COG0589	response to stress
HEP73_RS21585	COG3568	Endonuclease Exonuclease Phosphatase
HEP73_RS21590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_RS21595	COG0392	lysyltransferase activity
HEP73_RS21610	COG3275	phosphorelay sensor kinase activity
HEP73_RS21615	COG3279	Response regulator of the LytR AlgR family
HEP73_RS21625	COG0210	DNA helicase
HEP73_RS21715	COG0463	Glycosyl transferase, family 2
HEP73_RS21725	COG1475	DNA binding
HEP73_RS21730	COG1192	Involved in chromosome partitioning
HEP73_RS21735	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP73_RS21740	COG2091	lysine biosynthetic process via aminoadipic acid
HEP73_RS21765	COG1011	Hydrolase
HEP73_RS21770	COG0477	Major facilitator Superfamily
HEP73_RS21790	COG1971	Probably functions as a manganese efflux pump
HEP73_RS21805	COG0457	Tetratricopeptide repeat
HEP73_RS21810	COG2205	protein histidine kinase activity
HEP73_RS21820	COG5001	Diguanylate cyclase
HEP73_RS21825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP73_RS21830	COG3459	Glycosyltransferase 36 associated
HEP73_RS21835	COG2211	Major facilitator Superfamily
HEP73_RS21840	COG3265	gluconokinase activity
HEP73_RS21850	COG2155	Conserved Protein
HEP73_RS21855	COG2094	Belongs to the DNA glycosylase MPG family
HEP73_RS21870	COG2911	Protein conserved in bacteria
HEP73_RS21875	COG0729	surface antigen
HEP73_RS21895	COG3132	Protein of unknown function, DUF480
HEP73_RS21930	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HEP73_RS21935	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP73_RS21950	COG1609	Transcriptional regulator
HEP73_RS21965	COG2937	Belongs to the GPAT DAPAT family
HEP73_RS21985	COG2211	Major facilitator Superfamily
HEP73_RS22000	COG3693	PFAM glycoside hydrolase, family 10
HEP73_RS22010	COG3250	beta-galactosidase activity
HEP73_RS22030	COG3386	PFAM SMP-30 Gluconolaconase
HEP73_RS22040	COG0667	Aldo Keto reductase
HEP73_RS22045	COG0583	DNA-binding transcription factor activity
HEP73_RS22090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP73_RS22120	COG0246	Mannitol dehydrogenase
HEP73_RS22125	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP73_RS22135	COG4948	Mandelate Racemase Muconate Lactonizing
HEP73_RS22145	COG3661	Belongs to the glycosyl hydrolase 67 family
HEP73_RS22155	COG2115	Belongs to the xylose isomerase family
HEP73_RS22160	COG0037	tRNA processing
HEP73_RS22175	COG0840	transmembrane signaling receptor activity
HEP73_RS22185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEP73_RS22195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP73_RS22205	COG0805	protein transport
HEP73_RS22215	COG0519	Catalyzes the synthesis of GMP from XMP
HEP73_RS22215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP73_RS22240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP73_RS22255	COG0210	DNA helicase
HEP73_RS22265	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEP73_RS22280	COG2815	serine threonine protein kinase
HEP73_RS22280	COG0515	serine threonine protein kinase
HEP73_RS22290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP73_RS22325	COG1119	ATPase activity
HEP73_RS22340	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HEP73_RS22350	COG1335	isochorismatase
HEP73_RS22370	COG1733	regulation of RNA biosynthetic process
HEP73_RS22390	COG0706	membrane insertase activity
HEP73_RS22395	COG0594	ribonuclease P activity