locus-tag	class	description
HEP75_RS00010	COG0592	DNA-directed DNA polymerase activity
HEP75_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP75_RS00020	COG0187	DNA topoisomerase II activity
HEP75_RS00025	COG1266	CAAX protease self-immunity
HEP75_RS00030	COG0501	Belongs to the peptidase M48B family
HEP75_RS00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP75_RS00110	COG1280	lysine exporter protein (LysE YggA)
HEP75_RS00135	COG4772	TonB-dependent receptor
HEP75_RS00155	COG3284	Transcriptional regulator
HEP75_RS00160	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_RS00200	COG0277	FAD linked oxidase domain protein
HEP75_RS00210	COG2186	Transcriptional regulator
HEP75_RS00225	COG4585	Histidine kinase
HEP75_RS00230	COG2197	response regulator
HEP75_RS00285	COG2357	RelA SpoT domain protein
HEP75_RS00390	COG4771	TonB-dependent receptor
HEP75_RS00395	COG1629	transport
HEP75_RS00395	COG4774	siderophore transport
HEP75_RS00440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEP75_RS00455	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP75_RS00460	COG1609	Transcriptional regulator
HEP75_RS00470	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS00480	COG2755	lipolytic protein G-D-S-L family
HEP75_RS00490	COG3186	Phenylalanine-4-hydroxylase
HEP75_RS00495	COG1522	sequence-specific DNA binding
HEP75_RS00510	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEP75_RS00520	COG1595	DNA-templated transcription, initiation
HEP75_RS00530	COG3220	belongs to the UPF0276 family
HEP75_RS00580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HEP75_RS00615	COG1929	Belongs to the glycerate kinase type-1 family
HEP75_RS00625	COG2814	Major facilitator Superfamily
HEP75_RS00645	COG0531	amino acid
HEP75_RS00650	COG4566	intracellular signal transduction
HEP75_RS00655	COG4191	Histidine kinase
HEP75_RS00670	COG0625	glutathione transferase activity
HEP75_RS00675	COG1322	Protein conserved in bacteria
HEP75_RS00685	COG0386	Belongs to the glutathione peroxidase family
HEP75_RS00695	COG2853	Lipoprotein
HEP75_RS00710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP75_RS00715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP75_RS00720	COG1127	ABC transporter
HEP75_RS00755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEP75_RS00760	COG1074	ATP-dependent DNA helicase activity
HEP75_RS00765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP75_RS00800	COG0537	adenosine 5'-monophosphoramidase activity
HEP75_RS00860	COG0477	Major facilitator Superfamily
HEP75_RS00865	COG0302	gtp cyclohydrolase
HEP75_RS00890	COG0730	response to heat
HEP75_RS00905	COG2951	lytic endotransglycosylase activity
HEP75_RS00925	COG3135	benzoate transporter
HEP75_RS00960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP75_RS00965	COG1803	Methylglyoxal synthase
HEP75_RS00970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_RS00975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_RS00980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_RS00985	COG0493	'glutamate synthase
HEP75_RS00990	COG0069	glutamate synthase activity
HEP75_RS00990	COG0070	glutamate synthase
HEP75_RS00990	COG0067	glutamate synthase
HEP75_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS01045	COG1205	dead DEAH box helicase
HEP75_RS01045	COG1111	helicase
HEP75_RS01050	COG3549	Plasmid maintenance system killer
HEP75_RS01110	COG2271	Major facilitator Superfamily
HEP75_RS01120	COG0657	acetylesterase activity
HEP75_RS01180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP75_RS01185	COG1192	Involved in chromosome partitioning
HEP75_RS01200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP75_RS01205	COG2050	protein possibly involved in aromatic compounds catabolism
HEP75_RS01225	COG1881	PFAM PEBP family protein
HEP75_RS01235	COG0174	glutamine synthetase
HEP75_RS01240	COG0347	Belongs to the P(II) protein family
HEP75_RS01245	COG0004	ammonium transporteR
HEP75_RS01250	COG3852	Histidine kinase
HEP75_RS01255	COG2204	response regulator
HEP75_RS01260	COG2032	superoxide dismutase activity
HEP75_RS01265	COG2032	superoxide dismutase activity
HEP75_RS01275	COG0183	Belongs to the thiolase family
HEP75_RS01320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP75_RS01340	COG0702	epimerase
HEP75_RS01345	COG0583	DNA-binding transcription factor activity
HEP75_RS01360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEP75_RS01370	COG0612	Peptidase, M16
HEP75_RS01380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_RS01390	COG0596	Alpha beta hydrolase
HEP75_RS01400	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEP75_RS01405	COG0318	PFAM AMP-dependent synthetase and ligase
HEP75_RS01420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_RS01450	COG0564	pseudouridine synthase activity
HEP75_RS01480	COG1595	DNA-templated transcription, initiation
HEP75_RS01485	COG1446	asparaginase
HEP75_RS01490	COG0339	signal peptide processing
HEP75_RS01495	COG0681	Belongs to the peptidase S26 family
HEP75_RS01520	COG0583	DNA-binding transcription factor activity
HEP75_RS01525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP75_RS01530	COG2224	Isocitrate lyase
HEP75_RS01565	COG0659	secondary active sulfate transmembrane transporter activity
HEP75_RS01600	COG0583	DNA-binding transcription factor activity
HEP75_RS01605	COG1959	2 iron, 2 sulfur cluster binding
HEP75_RS01615	COG1690	Belongs to the RtcB family
HEP75_RS01635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP75_RS01640	COG2130	NADP-dependent
HEP75_RS01655	COG1187	pseudouridine synthase activity
HEP75_RS01670	COG1643	Atp-dependent helicase
HEP75_RS01675	COG0084	hydrolase, TatD family'
HEP75_RS01780	COG0842	Transport permease protein
HEP75_RS01785	COG1131	(ABC) transporter
HEP75_RS01790	COG0633	Ferredoxin
HEP75_RS01790	COG0543	2 iron, 2 sulfur cluster binding
HEP75_RS01795	COG2207	Transcriptional regulator
HEP75_RS01795	COG0662	Cupin 2, conserved barrel domain protein
HEP75_RS01810	COG1476	TRANSCRIPTIONal
HEP75_RS01820	COG4555	ABC transporter
HEP75_RS01840	COG0625	glutathione transferase activity
HEP75_RS01875	COG0028	Belongs to the TPP enzyme family
HEP75_RS01900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_RS01920	COG1199	ATP-dependent helicase activity
HEP75_RS01980	COG0628	permease
HEP75_RS02005	COG2133	pyrroloquinoline quinone binding
HEP75_RS02060	COG0443	Heat shock 70 kDa protein
HEP75_RS02100	COG0754	glutathionylspermidine amidase activity
HEP75_RS02150	COG2831	hemolysin activation secretion protein
HEP75_RS02160	COG0714	Associated with various cellular activities
HEP75_RS02190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEP75_RS02205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS02210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_RS02220	COG3541	Predicted nucleotidyltransferase
HEP75_RS02235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP75_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS02275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP75_RS02285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP75_RS02305	COG0606	chelatase, subunit chli
HEP75_RS02310	COG2960	long-chain fatty acid transporting porin activity
HEP75_RS02335	COG1166	arginine decarboxylase activity
HEP75_RS02340	COG2755	lipolytic protein G-D-S-L family
HEP75_RS02340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP75_RS02345	COG0583	DNA-binding transcription factor activity
HEP75_RS02365	COG4221	oxidoreductase activity
HEP75_RS02385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEP75_RS02395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP75_RS02405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP75_RS02415	COG2814	Major facilitator Superfamily
HEP75_RS02425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEP75_RS02430	COG0739	heme binding
HEP75_RS02435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP75_RS02470	COG1064	alcohol dehydrogenase
HEP75_RS02475	COG2234	aminopeptidase activity
HEP75_RS02485	COG4942	peptidase
HEP75_RS02490	COG0793	Belongs to the peptidase S41A family
HEP75_RS02520	COG0531	amino acid
HEP75_RS02530	COG1486	melibiose metabolic process
HEP75_RS02545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP75_RS02545	COG1565	acr, cog1565
HEP75_RS02550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP75_RS02555	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HEP75_RS02560	COG1845	cytochrome c oxidase, subunit III
HEP75_RS02580	COG1612	heme a metabolic process
HEP75_RS02585	COG0109	protoheme IX farnesyltransferase activity
HEP75_RS02605	COG0358	DNA primase activity
HEP75_RS02610	COG1295	ribonuclease BN
HEP75_RS02615	COG1610	YqeY-like protein
HEP75_RS02630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP75_RS02635	COG2308	Evidence 4 Homologs of previously reported genes of
HEP75_RS02650	COG2133	pyrroloquinoline quinone binding
HEP75_RS02670	COG0531	amino acid
HEP75_RS02680	COG4948	Mandelate Racemase Muconate Lactonizing
HEP75_RS02690	COG4771	TonB-dependent receptor
HEP75_RS02695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP75_RS02730	COG3409	Peptidoglycan-binding domain 1 protein
HEP75_RS02730	COG3501	Rhs element vgr protein
HEP75_RS02740	COG0477	Major facilitator Superfamily
HEP75_RS02780	COG5383	Protein conserved in bacteria
HEP75_RS02800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS02815	COG1652	LysM domain
HEP75_RS02840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP75_RS02845	COG3118	belongs to the thioredoxin family
HEP75_RS02855	COG2884	Cell division ATP-binding protein ftsE
HEP75_RS02860	COG2177	Part of the ABC transporter FtsEX involved in
HEP75_RS02865	COG2201	protein-glutamate methylesterase activity
HEP75_RS02875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP75_RS02880	COG2860	membrane
HEP75_RS02885	COG1252	NADH dehydrogenase
HEP75_RS02895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEP75_RS02905	COG0534	Mate efflux family protein
HEP75_RS02910	COG0616	signal peptide processing
HEP75_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS02935	COG0009	L-threonylcarbamoyladenylate synthase
HEP75_RS02940	COG1754	DNA topoisomerase type I activity
HEP75_RS02940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP75_RS02945	COG1714	RDD family
HEP75_RS02960	COG0758	DNA mediated transformation
HEP75_RS02965	COG1652	LysM domain
HEP75_RS02970	COG0242	peptide deformylase activity
HEP75_RS02980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEP75_RS02980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP75_RS02985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP75_RS02995	COG3307	-O-antigen
HEP75_RS03000	COG1215	transferase activity, transferring glycosyl groups
HEP75_RS03020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP75_RS03025	COG1247	-acetyltransferase
HEP75_RS03035	COG1490	D-aminoacyl-tRNA deacylase activity
HEP75_RS03040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP75_RS03055	COG1609	Transcriptional regulator
HEP75_RS03060	COG3537	Alpha-1,2-mannosidase
HEP75_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS03075	COG0583	DNA-binding transcription factor activity
HEP75_RS03080	COG0366	Alpha amylase catalytic
HEP75_RS03085	COG0366	Alpha amylase catalytic
HEP75_RS03090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP75_RS03185	COG4974	Belongs to the 'phage' integrase family
HEP75_RS03225	COG0443	Heat shock 70 kDa protein
HEP75_RS03245	COG0300	oxidoreductase activity
HEP75_RS03260	COG3550	peptidyl-serine autophosphorylation
HEP75_RS03275	COG0024	Methionine aminopeptidase
HEP75_RS03305	COG4773	Receptor
HEP75_RS03320	COG2207	Transcriptional regulator
HEP75_RS03335	COG1309	transcriptional regulator
HEP75_RS03355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_RS03355	COG2124	cytochrome p450
HEP75_RS03360	COG1309	transcriptional regulator
HEP75_RS03370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP75_RS03375	COG2271	Major facilitator Superfamily
HEP75_RS03400	COG0745	RESPONSE REGULATOR receiver
HEP75_RS03405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HEP75_RS03405	COG3266	domain, Protein
HEP75_RS03405	COG4932	domain protein
HEP75_RS03425	COG0840	transmembrane signaling receptor activity
HEP75_RS03445	COG3546	catalase activity
HEP75_RS03450	COG3685	Protein conserved in bacteria
HEP75_RS03455	COG3685	Protein conserved in bacteria
HEP75_RS03460	COG0588	phosphoglycerate mutase activity
HEP75_RS03465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP75_RS03470	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS03480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP75_RS03515	COG0028	Belongs to the TPP enzyme family
HEP75_RS03520	COG4191	Histidine kinase
HEP75_RS03545	COG1648	precorrin-2 dehydrogenase activity
HEP75_RS03545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP75_RS03555	COG1116	anion transmembrane transporter activity
HEP75_RS03555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEP75_RS03565	COG2223	nitrite transmembrane transporter activity
HEP75_RS03570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP75_RS03575	COG2146	nitrite reductase [NAD(P)H] activity
HEP75_RS03580	COG0243	molybdopterin cofactor binding
HEP75_RS03605	COG1640	4-alpha-glucanotransferase
HEP75_RS03610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP75_RS03620	COG0297	glycogen (starch) synthase activity
HEP75_RS03630	COG0745	RESPONSE REGULATOR receiver
HEP75_RS03640	COG1335	isochorismatase
HEP75_RS03660	COG0181	hydroxymethylbilane synthase activity
HEP75_RS03675	COG1733	regulation of RNA biosynthetic process
HEP75_RS03690	COG1505	serine-type exopeptidase activity
HEP75_RS03695	COG0436	Aminotransferase
HEP75_RS03705	COG2832	Protein of unknown function (DUF454)
HEP75_RS03715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEP75_RS03740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HEP75_RS03745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP75_RS03750	COG0366	Alpha amylase catalytic
HEP75_RS03765	COG3345	alpha-galactosidase
HEP75_RS03775	COG2222	sugar isomerase
HEP75_RS03780	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HEP75_RS03800	COG1349	DNA-binding transcription factor activity
HEP75_RS03870	COG3250	beta-galactosidase activity
HEP75_RS03885	COG2188	Transcriptional regulator
HEP75_RS03895	COG1609	Transcriptional regulator
HEP75_RS03900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP75_RS03905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEP75_RS03930	COG3250	beta-galactosidase activity
HEP75_RS03950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP75_RS03965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HEP75_RS03975	COG2207	Transcriptional regulator
HEP75_RS03995	COG3738	Protein conserved in bacteria
HEP75_RS04015	COG2205	protein histidine kinase activity
HEP75_RS04040	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP75_RS04045	COG3791	Glutathione-dependent formaldehyde-activating
HEP75_RS04075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP75_RS04085	COG0697	spore germination
HEP75_RS04095	COG1307	EDD domain protein, DegV family
HEP75_RS04110	COG0804	urea catabolic process
HEP75_RS04115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP75_RS04130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP75_RS04155	COG0436	Aminotransferase
HEP75_RS04175	COG1162	GTPase activity
HEP75_RS04200	COG2211	Major facilitator Superfamily
HEP75_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS04215	COG2851	Citrate transporter
HEP75_RS04235	COG0642	Histidine kinase
HEP75_RS04245	COG2205	protein histidine kinase activity
HEP75_RS04245	COG3292	Two component regulator propeller
HEP75_RS04245	COG0745	RESPONSE REGULATOR receiver
HEP75_RS04245	COG3292	Two component regulator propeller
HEP75_RS04245	COG0745	RESPONSE REGULATOR receiver
HEP75_RS04245	COG2205	protein histidine kinase activity
HEP75_RS04260	COG4191	Histidine kinase
HEP75_RS04270	COG1301	dicarboxylic acid transport
HEP75_RS04275	COG0280	phosphate acetyltransferase
HEP75_RS04275	COG0281	malic enzyme
HEP75_RS04300	COG1560	Kdo2-lipid A biosynthetic process
HEP75_RS04305	COG1519	Transferase
HEP75_RS04310	COG1538	Outer membrane efflux protein
HEP75_RS04315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP75_RS04330	COG0473	3-isopropylmalate dehydrogenase activity
HEP75_RS04335	COG0066	3-isopropylmalate dehydratase activity
HEP75_RS04350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP75_RS04355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP75_RS04375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP75_RS04385	COG2815	serine threonine protein kinase
HEP75_RS04385	COG0515	serine threonine protein kinase
HEP75_RS04390	COG0405	Gamma-glutamyltransferase
HEP75_RS04395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HEP75_RS04400	COG0840	transmembrane signaling receptor activity
HEP75_RS04415	COG0823	Involved in the tonB-independent uptake of proteins
HEP75_RS04435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP75_RS04445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP75_RS04485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP75_RS04495	COG0671	phosphoesterase, PA-phosphatase related
HEP75_RS04510	COG1940	carbohydrate kinase activity
HEP75_RS04515	COG0346	lactoylglutathione lyase activity
HEP75_RS04520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP75_RS04525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP75_RS04535	COG4206	TonB-dependent receptor
HEP75_RS04545	COG2010	Cytochrome c
HEP75_RS04555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP75_RS04560	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HEP75_RS04565	COG2909	trisaccharide binding
HEP75_RS04570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP75_RS04585	COG1773	rubredoxin
HEP75_RS04610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP75_RS04640	COG3079	Belongs to the UPF0149 family
HEP75_RS04645	COG0006	proline dipeptidase activity
HEP75_RS04650	COG0006	proline dipeptidase activity
HEP75_RS04665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP75_RS04670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP75_RS04675	COG0346	lactoylglutathione lyase activity
HEP75_RS04680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP75_RS04685	COG1561	YicC-like family, N-terminal region
HEP75_RS04690	COG0194	GDP metabolic process
HEP75_RS04695	COG1758	RNA polymerase activity
HEP75_RS04700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP75_RS04710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP75_RS04720	COG0254	rRNA binding
HEP75_RS04725	COG0372	Belongs to the citrate synthase family
HEP75_RS04740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP75_RS04770	COG0714	Associated with various cellular activities
HEP75_RS04805	COG1301	dicarboxylic acid transport
HEP75_RS04810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP75_RS04835	COG0739	heme binding
HEP75_RS04840	COG1376	ErfK ybiS ycfS ynhG family protein
HEP75_RS04880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HEP75_RS04885	COG4149	molybdate abc transporter
HEP75_RS04890	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP75_RS04900	COG0640	Transcriptional regulator
HEP75_RS04915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_RS04925	COG3591	Belongs to the peptidase S1B family
HEP75_RS04955	COG3047	cAMP biosynthetic process
HEP75_RS04960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP75_RS04985	COG1902	pentaerythritol trinitrate reductase activity
HEP75_RS04990	COG0300	oxidoreductase activity
HEP75_RS04995	COG4221	oxidoreductase activity
HEP75_RS05005	COG0604	alcohol dehydrogenase
HEP75_RS05010	COG0840	transmembrane signaling receptor activity
HEP75_RS05035	COG0469	pyruvate kinase activity
HEP75_RS05040	COG3588	fructose-bisphosphate aldolase
HEP75_RS05050	COG2205	protein histidine kinase activity
HEP75_RS05065	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP75_RS05110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP75_RS05130	COG2072	flavoprotein involved in K transport
HEP75_RS05135	COG2351	hydroxyisourate hydrolase activity
HEP75_RS05145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP75_RS05175	COG0784	Response regulator, receiver
HEP75_RS05175	COG2205	protein histidine kinase activity
HEP75_RS05175	COG2198	Histidine kinase
HEP75_RS05180	COG0431	NADPH-dependent FMN reductase
HEP75_RS05185	COG1393	Belongs to the ArsC family
HEP75_RS05210	COG0175	sulfate reduction
HEP75_RS05215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP75_RS05220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_RS05230	COG2895	sulfate adenylyltransferase (ATP) activity
HEP75_RS05230	COG0529	Catalyzes the synthesis of activated sulfate
HEP75_RS05240	COG0438	transferase activity, transferring glycosyl groups
HEP75_RS05260	COG1115	amino acid carrier protein
HEP75_RS05270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP75_RS05295	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP75_RS05310	COG0471	metal ion transport
HEP75_RS05310	COG3273	potassium ion transport
HEP75_RS05320	COG2022	thiamine diphosphate biosynthetic process
HEP75_RS05345	COG3511	phospholipase C
HEP75_RS05355	COG0189	ligase activity
HEP75_RS05365	COG0745	RESPONSE REGULATOR receiver
HEP75_RS05380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEP75_RS05405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEP75_RS05425	COG1216	Glycosyl transferase, family 2
HEP75_RS05455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP75_RS05455	COG2755	lipolytic protein G-D-S-L family
HEP75_RS05465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP75_RS05465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP75_RS05475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP75_RS05485	COG1174	glycine betaine transport
HEP75_RS05490	COG1125	glycine betaine transport
HEP75_RS05500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP75_RS05505	COG0564	pseudouridine synthase activity
HEP75_RS05525	COG0840	transmembrane signaling receptor activity
HEP75_RS05530	COG4993	Dehydrogenase
HEP75_RS05550	COG3387	PFAM Glycoside hydrolase 15-related
HEP75_RS05555	COG1877	trehalose-phosphatase activity
HEP75_RS05570	COG4771	TonB-dependent receptor
HEP75_RS05580	COG0454	-acetyltransferase
HEP75_RS05605	COG0542	response to heat
HEP75_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS05645	COG2223	nitrite transmembrane transporter activity
HEP75_RS05655	COG0019	diaminopimelate decarboxylase activity
HEP75_RS05660	COG4264	IucA IucC family
HEP75_RS05665	COG2814	Major facilitator Superfamily
HEP75_RS05670	COG4264	IucA IucC family
HEP75_RS05680	COG4772	TonB-dependent receptor
HEP75_RS05690	COG4651	solute:proton antiporter activity
HEP75_RS05690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP75_RS05720	COG0488	(ABC) transporter
HEP75_RS05750	COG0657	acetylesterase activity
HEP75_RS05750	COG2755	lipolytic protein G-D-S-L family
HEP75_RS05760	COG4774	siderophore transport
HEP75_RS05800	COG0217	transcriptional regulatory protein
HEP75_RS05810	COG0632	four-way junction helicase activity
HEP75_RS05825	COG0824	Thioesterase
HEP75_RS05835	COG0848	biopolymer transport protein
HEP75_RS05845	COG0823	Involved in the tonB-independent uptake of proteins
HEP75_RS05850	COG2885	chlorophyll binding
HEP75_RS05860	COG0602	queuosine metabolic process
HEP75_RS05865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEP75_RS05900	COG0514	ATP-dependent DNA helicase (RecQ)
HEP75_RS05910	COG0783	Belongs to the Dps family
HEP75_RS05915	COG1643	Atp-dependent helicase
HEP75_RS05955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP75_RS05965	COG1216	Glycosyl transferase, family 2
HEP75_RS05970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP75_RS05980	COG1199	ATP-dependent helicase activity
HEP75_RS05990	COG1397	ADP-ribosylglycohydrolase
HEP75_RS06005	COG0189	ligase activity
HEP75_RS06020	COG0835	chemotaxis
HEP75_RS06025	COG0840	transmembrane signaling receptor activity
HEP75_RS06030	COG2198	Histidine kinase
HEP75_RS06030	COG0784	Response regulator, receiver
HEP75_RS06030	COG0643	Histidine kinase
HEP75_RS06035	COG2201	protein-glutamate methylesterase activity
HEP75_RS06060	COG1446	asparaginase
HEP75_RS06135	COG3279	Response regulator of the LytR AlgR family
HEP75_RS06140	COG3275	phosphorelay sensor kinase activity
HEP75_RS06145	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HEP75_RS06165	COG0583	DNA-binding transcription factor activity
HEP75_RS06185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP75_RS06245	COG3537	Alpha-1,2-mannosidase
HEP75_RS06255	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_RS06265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP75_RS06270	COG3858	chitin binding
HEP75_RS06270	COG1388	LysM domain
HEP75_RS06285	COG0837	glucose binding
HEP75_RS06295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEP75_RS06305	COG0494	nUDIX hydrolase
HEP75_RS06315	COG3956	TIGRFAM MazG family protein
HEP75_RS06330	COG0330	HflC and HflK could
HEP75_RS06370	COG0697	spore germination
HEP75_RS06395	COG1960	acyl-CoA dehydrogenase activity
HEP75_RS06420	COG0457	Tetratricopeptide repeat
HEP75_RS06435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEP75_RS06440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP75_RS06445	COG0463	Glycosyl transferase, family 2
HEP75_RS06450	COG0517	IMP dehydrogenase activity
HEP75_RS06455	COG2982	Protein involved in outer membrane biogenesis
HEP75_RS06460	COG1272	protein, Hemolysin III
HEP75_RS06465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEP75_RS06475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP75_RS06480	COG0626	cystathionine gamma-synthase activity
HEP75_RS06485	COG0460	homoserine dehydrogenase
HEP75_RS06485	COG0527	aspartate kinase activity
HEP75_RS06500	COG1760	l-serine dehydratase
HEP75_RS06515	COG3038	cytochrome b561
HEP75_RS06535	COG0477	Major facilitator Superfamily
HEP75_RS06540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP75_RS06555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP75_RS06625	COG3706	GGDEF domain
HEP75_RS06665	COG0519	Catalyzes the synthesis of GMP from XMP
HEP75_RS06680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP75_RS06725	COG1113	amino acid transport
HEP75_RS06745	COG2239	Acts as a magnesium transporter
HEP75_RS06750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP75_RS06755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP75_RS06765	COG1660	Displays ATPase and GTPase activities
HEP75_RS06775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP75_RS06790	COG1137	ATPase activity
HEP75_RS06805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEP75_RS06840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEP75_RS06865	COG0628	permease
HEP75_RS06875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP75_RS06880	COG3178	'Phosphotransferase
HEP75_RS06895	COG1555	photosystem II stabilization
HEP75_RS06925	COG2814	Major facilitator Superfamily
HEP75_RS06935	COG1335	isochorismatase
HEP75_RS06945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_RS06950	COG1477	protein flavinylation
HEP75_RS06975	COG4774	siderophore transport
HEP75_RS06980	COG2146	nitrite reductase [NAD(P)H] activity
HEP75_RS06990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP75_RS06995	COG0719	Fe-S assembly protein
HEP75_RS07000	COG0396	ATPase activity
HEP75_RS07005	COG0719	Fe-S assembly protein
HEP75_RS07020	COG0693	protein deglycase activity
HEP75_RS07035	COG0739	heme binding
HEP75_RS07050	COG1764	response to oxidative stress
HEP75_RS07060	COG0384	phenazine biosynthesis protein PhzF
HEP75_RS07065	COG0527	aspartate kinase activity
HEP75_RS07090	COG0142	geranyltranstransferase activity
HEP75_RS07095	COG0629	single-stranded DNA binding
HEP75_RS07105	COG1858	cytochrome C peroxidase
HEP75_RS07140	COG4615	Cyclic peptide transporter
HEP75_RS07165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS07170	COG0577	efflux transmembrane transporter activity
HEP75_RS07170	COG1136	(ABC) transporter
HEP75_RS07175	COG0577	efflux transmembrane transporter activity
HEP75_RS07175	COG1136	(ABC) transporter
HEP75_RS07190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP75_RS07220	COG2010	Cytochrome c
HEP75_RS07230	COG0673	inositol 2-dehydrogenase activity
HEP75_RS07235	COG2211	Major facilitator Superfamily
HEP75_RS07245	COG1609	Transcriptional regulator
HEP75_RS07275	COG3104	oligopeptide transport
HEP75_RS07280	COG1297	OPT oligopeptide transporter protein
HEP75_RS07285	COG0823	Involved in the tonB-independent uptake of proteins
HEP75_RS07285	COG1506	peptidase
HEP75_RS07305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP75_RS07310	COG2879	small protein
HEP75_RS07315	COG1966	Carbon starvation protein
HEP75_RS07320	COG1741	Belongs to the pirin family
HEP75_RS07330	COG1741	Belongs to the pirin family
HEP75_RS07340	COG1515	deoxyribonuclease V activity
HEP75_RS07360	COG2211	Major facilitator Superfamily
HEP75_RS07370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP75_RS07385	COG3706	GGDEF domain
HEP75_RS07385	COG5001	Diguanylate cyclase
HEP75_RS07385	COG2203	Gaf domain
HEP75_RS07385	COG4251	negative regulation of phosphorylation
HEP75_RS07390	COG0835	chemotaxis
HEP75_RS07395	COG0840	transmembrane signaling receptor activity
HEP75_RS07405	COG0840	transmembrane signaling receptor activity
HEP75_RS07410	COG0643	Histidine kinase
HEP75_RS07410	COG2198	Histidine kinase
HEP75_RS07420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEP75_RS07435	COG3878	Protein conserved in bacteria
HEP75_RS07440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEP75_RS07450	COG0642	Histidine kinase
HEP75_RS07455	COG3111	PFAM Bacterial OB fold (BOF) protein
HEP75_RS07460	COG0745	RESPONSE REGULATOR receiver
HEP75_RS07465	COG2205	protein histidine kinase activity
HEP75_RS07470	COG4452	Inner membrane protein CreD
HEP75_RS07495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP75_RS07500	COG0735	belongs to the Fur family
HEP75_RS07535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_RS07545	COG1309	transcriptional regulator
HEP75_RS07560	COG3214	Protein conserved in bacteria
HEP75_RS07580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP75_RS07585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP75_RS07590	COG2080	2 iron, 2 sulfur cluster binding
HEP75_RS07625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP75_RS07690	COG1187	pseudouridine synthase activity
HEP75_RS07715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP75_RS07720	COG3795	YCII-related domain
HEP75_RS07740	COG4941	Belongs to the sigma-70 factor family
HEP75_RS07765	COG1132	(ABC) transporter
HEP75_RS07800	COG0583	DNA-binding transcription factor activity
HEP75_RS07845	COG1981	membrane
HEP75_RS07855	COG0825	malonyl-CoA metabolic process
HEP75_RS07875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP75_RS07895	COG0750	zinc metalloprotease
HEP75_RS07900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP75_RS07905	COG0575	Belongs to the CDS family
HEP75_RS07910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP75_RS07920	COG0528	UMP kinase activity
HEP75_RS07930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP75_RS07970	COG0024	Methionine aminopeptidase
HEP75_RS07985	COG1393	Belongs to the ArsC family
HEP75_RS07990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP75_RS07995	COG0367	asparagine synthase
HEP75_RS08050	COG1566	PFAM secretion protein HlyD family protein
HEP75_RS08055	COG2814	Major facilitator Superfamily
HEP75_RS08100	COG0557	exoribonuclease II activity
HEP75_RS08110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP75_RS08135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP75_RS08155	COG0704	Plays a role in the regulation of phosphate uptake
HEP75_RS08165	COG0581	inorganic phosphate transmembrane transporter activity
HEP75_RS08180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP75_RS08200	COG0659	secondary active sulfate transmembrane transporter activity
HEP75_RS08205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEP75_RS08215	COG1024	Enoyl-CoA hydratase
HEP75_RS08260	COG0488	(ABC) transporter
HEP75_RS08275	COG5002	protein histidine kinase activity
HEP75_RS08275	COG0784	Response regulator, receiver
HEP75_RS08275	COG2205	protein histidine kinase activity
HEP75_RS08280	COG2733	membrane
HEP75_RS08295	COG2205	protein histidine kinase activity
HEP75_RS08320	COG0686	Belongs to the AlaDH PNT family
HEP75_RS08325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP75_RS08330	COG1396	sequence-specific DNA binding
HEP75_RS08330	COG1917	Cupin 2, conserved barrel domain protein
HEP75_RS08335	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_RS08355	COG0243	molybdopterin cofactor binding
HEP75_RS08365	COG0477	Major facilitator Superfamily
HEP75_RS08375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_RS08380	COG0174	glutamine synthetase
HEP75_RS08385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP75_RS08390	COG0174	glutamine synthetase
HEP75_RS08405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP75_RS08410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP75_RS08430	COG3842	ATPase activity
HEP75_RS08435	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP75_RS08440	COG1177	transmembrane transport
HEP75_RS08445	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_RS08450	COG0598	Magnesium transport protein CorA
HEP75_RS08460	COG4535	Mg2 and Co2 transporter CorC
HEP75_RS08490	COG1702	phosphate starvation-inducible protein PhoH
HEP75_RS08505	COG0625	glutathione transferase activity
HEP75_RS08515	COG0741	lytic transglycosylase activity
HEP75_RS08520	COG0723	plastoquinol--plastocyanin reductase activity
HEP75_RS08525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP75_RS08535	COG2857	Cytochrome c1
HEP75_RS08540	COG0625	glutathione transferase activity
HEP75_RS08545	COG2969	positive regulation of protein catabolic process
HEP75_RS08585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP75_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS08595	COG2095	MarC family integral membrane protein
HEP75_RS08610	COG1611	Belongs to the LOG family
HEP75_RS08615	COG3275	phosphorelay sensor kinase activity
HEP75_RS08660	COG0556	nucleotide-excision repair
HEP75_RS08695	COG2948	multi-organism process
HEP75_RS08715	COG3702	type iv secretory pathway
HEP75_RS08740	COG0366	Alpha amylase catalytic
HEP75_RS08790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP75_RS08800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP75_RS08805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP75_RS08810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP75_RS08810	COG0072	phenylalanine-tRNA ligase activity
HEP75_RS08855	COG0438	transferase activity, transferring glycosyl groups
HEP75_RS08870	COG0438	transferase activity, transferring glycosyl groups
HEP75_RS08895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP75_RS08905	COG1960	acyl-CoA dehydrogenase activity
HEP75_RS08925	COG1846	Transcriptional regulator
HEP75_RS08960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEP75_RS08965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP75_RS08965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEP75_RS08970	COG0802	atpase or kinase
HEP75_RS08975	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP75_RS08980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP75_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS09020	COG2081	HI0933 family
HEP75_RS09025	COG4681	YaeQ
HEP75_RS09030	COG0564	pseudouridine synthase activity
HEP75_RS09040	COG0625	glutathione transferase activity
HEP75_RS09045	COG0657	acetylesterase activity
HEP75_RS09080	COG0513	Belongs to the DEAD box helicase family
HEP75_RS09085	COG0488	(ABC) transporter
HEP75_RS09100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP75_RS09105	COG2207	Transcriptional regulator
HEP75_RS09120	COG2197	response regulator
HEP75_RS09130	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_RS09165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP75_RS09170	COG1846	Transcriptional regulator
HEP75_RS09175	COG0339	signal peptide processing
HEP75_RS09180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP75_RS09185	COG0386	Belongs to the glutathione peroxidase family
HEP75_RS09215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP75_RS09260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEP75_RS09275	COG0084	hydrolase, TatD family'
HEP75_RS09290	COG1960	acyl-CoA dehydrogenase activity
HEP75_RS09305	COG0305	Participates in initiation and elongation during chromosome replication
HEP75_RS09320	COG2204	response regulator
HEP75_RS09330	COG0415	Belongs to the DNA photolyase family
HEP75_RS09345	COG0583	DNA-binding transcription factor activity
HEP75_RS09360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS09370	COG1201	RNA secondary structure unwinding
HEP75_RS09375	COG3290	protein histidine kinase activity
HEP75_RS09375	COG0840	transmembrane signaling receptor activity
HEP75_RS09380	COG0835	chemotaxis
HEP75_RS09415	COG2304	oxidoreductase activity
HEP75_RS09430	COG1194	a g-specific adenine glycosylase
HEP75_RS09435	COG0552	protein localization to endoplasmic reticulum
HEP75_RS09445	COG3938	Belongs to the proline racemase family
HEP75_RS09450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_RS09465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP75_RS09475	COG0006	proline dipeptidase activity
HEP75_RS09490	COG0531	amino acid
HEP75_RS09525	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP75_RS09535	COG4771	TonB-dependent receptor
HEP75_RS09545	COG3345	alpha-galactosidase
HEP75_RS09565	COG3209	COG3209 Rhs family protein
HEP75_RS09580	COG0742	ribosomal rna small subunit methyltransferase
HEP75_RS09595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEP75_RS09605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP75_RS09610	COG3291	Pkd domain containing protein
HEP75_RS09630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP75_RS09635	COG0657	acetylesterase activity
HEP75_RS09635	COG2755	lipolytic protein G-D-S-L family
HEP75_RS09645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP75_RS09655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP75_RS09660	COG0343	queuine tRNA-ribosyltransferase activity
HEP75_RS09665	COG1862	Preprotein translocase
HEP75_RS09705	COG1509	lysine 2,3-aminomutase activity
HEP75_RS09715	COG3548	integral membrane protein
HEP75_RS09720	COG0402	S-adenosylhomocysteine deaminase activity
HEP75_RS09740	COG4677	pectinesterase activity
HEP75_RS09745	COG4302	ethanolamine ammonia-lyase activity
HEP75_RS09750	COG4303	Ethanolamine ammonia lyase large subunit
HEP75_RS09775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP75_RS09810	COG4993	Dehydrogenase
HEP75_RS09810	COG2010	Cytochrome c
HEP75_RS09845	COG2166	iron-sulfur cluster assembly
HEP75_RS09860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP75_RS09865	COG0137	argininosuccinate synthase activity
HEP75_RS09875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP75_RS09880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP75_RS09890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP75_RS09895	COG0165	Argininosuccinate lyase
HEP75_RS09915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP75_RS09935	COG1064	alcohol dehydrogenase
HEP75_RS09965	COG1294	oxidase, subunit
HEP75_RS09975	COG4988	ABC transporter
HEP75_RS09980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEP75_RS09985	COG1278	Cold shock
HEP75_RS09990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP75_RS10015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HEP75_RS10035	COG4133	protoheme IX ABC transporter activity
HEP75_RS10040	COG0436	Aminotransferase
HEP75_RS10065	COG1187	pseudouridine synthase activity
HEP75_RS10070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP75_RS10075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEP75_RS10080	COG2350	Protein conserved in bacteria
HEP75_RS10120	COG0395	ABC-type sugar transport system, permease component
HEP75_RS10130	COG0800	Aldolase
HEP75_RS10135	COG0129	dihydroxy-acid dehydratase activity
HEP75_RS10150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP75_RS10160	COG0354	folic acid binding
HEP75_RS10175	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEP75_RS10200	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP75_RS10215	COG2333	competence protein COMEC
HEP75_RS10215	COG0658	competence protein
HEP75_RS10220	COG0811	peptide transport
HEP75_RS10230	COG1132	(ABC) transporter
HEP75_RS10235	COG1663	tetraacyldisaccharide 4'-kinase activity
HEP75_RS10250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP75_RS10265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP75_RS10315	COG0348	domain, Protein
HEP75_RS10325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP75_RS10335	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HEP75_RS10340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP75_RS10350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP75_RS10390	COG1136	(ABC) transporter
HEP75_RS10390	COG0577	efflux transmembrane transporter activity
HEP75_RS10420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP75_RS10420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP75_RS10425	COG1105	Belongs to the carbohydrate kinase PfkB family
HEP75_RS10430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP75_RS10430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP75_RS10435	COG1609	Transcriptional regulator
HEP75_RS10450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP75_RS10455	COG0069	glutamate synthase activity
HEP75_RS10490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP75_RS10505	COG1253	flavin adenine dinucleotide binding
HEP75_RS10515	COG0306	phosphate transporter
HEP75_RS10535	COG0504	CTP synthase activity
HEP75_RS10555	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HEP75_RS10560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP75_RS10565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP75_RS10580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEP75_RS10590	COG1238	metal cluster binding
HEP75_RS10605	COG1534	Rna-binding protein
HEP75_RS10610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HEP75_RS10615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP75_RS10620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP75_RS10635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP75_RS10640	COG1546	Belongs to the CinA family
HEP75_RS10645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP75_RS10650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP75_RS10655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP75_RS10660	COG2137	regulation of response to DNA damage stimulus
HEP75_RS10665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP75_RS10670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEP75_RS10760	COG2003	Belongs to the UPF0758 family
HEP75_RS10880	COG0194	GDP metabolic process
HEP75_RS10895	COG1741	Belongs to the pirin family
HEP75_RS10900	COG0583	DNA-binding transcription factor activity
HEP75_RS10925	COG0352	thiamine-phosphate diphosphorylase activity
HEP75_RS10925	COG0351	phosphomethylpyrimidine kinase
HEP75_RS10940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP75_RS10945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEP75_RS10955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP75_RS10965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEP75_RS10970	COG3734	2-keto-3-deoxy-galactonokinase
HEP75_RS10985	COG0800	Aldolase
HEP75_RS11020	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP75_RS11030	COG1070	Carbohydrate kinase
HEP75_RS11035	COG2115	Belongs to the xylose isomerase family
HEP75_RS11040	COG0477	Major facilitator Superfamily
HEP75_RS11050	COG0617	tRNA 3'-terminal CCA addition
HEP75_RS11060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP75_RS11075	COG0166	Belongs to the GPI family
HEP75_RS11095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HEP75_RS11110	COG0671	phosphoesterase, PA-phosphatase related
HEP75_RS11115	COG1794	racemase activity, acting on amino acids and derivatives
HEP75_RS11130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP75_RS11155	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_RS11175	COG0527	aspartate kinase activity
HEP75_RS11175	COG0460	homoserine dehydrogenase
HEP75_RS11185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP75_RS11195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP75_RS11200	COG0124	histidyl-tRNA synthetase
HEP75_RS11210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP75_RS11215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP75_RS11220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP75_RS11230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP75_RS11245	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP75_RS11245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP75_RS11260	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP75_RS11265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP75_RS11270	COG0235	Class ii aldolase
HEP75_RS11275	COG0531	amino acid
HEP75_RS11280	COG0531	amino acid
HEP75_RS11295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP75_RS11300	COG0277	FAD linked oxidase domain protein
HEP75_RS11320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP75_RS11340	COG1024	Enoyl-CoA hydratase
HEP75_RS11375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP75_RS11380	COG2258	MOSC domain
HEP75_RS11390	COG0505	Belongs to the CarA family
HEP75_RS11400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP75_RS11405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP75_RS11420	COG4676	Protein conserved in bacteria
HEP75_RS11425	COG3279	Response regulator of the LytR AlgR family
HEP75_RS11430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP75_RS11435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP75_RS11450	COG2205	protein histidine kinase activity
HEP75_RS11450	COG2198	Histidine kinase
HEP75_RS11450	COG0784	Response regulator, receiver
HEP75_RS11455	COG1024	Enoyl-CoA hydratase
HEP75_RS11460	COG0318	PFAM AMP-dependent synthetase and ligase
HEP75_RS11530	COG0840	transmembrane signaling receptor activity
HEP75_RS11540	COG0835	chemotaxis
HEP75_RS11550	COG0840	transmembrane signaling receptor activity
HEP75_RS11555	COG0840	transmembrane signaling receptor activity
HEP75_RS11565	COG0840	transmembrane signaling receptor activity
HEP75_RS11575	COG0840	transmembrane signaling receptor activity
HEP75_RS11585	COG0840	transmembrane signaling receptor activity
HEP75_RS11595	COG0840	transmembrane signaling receptor activity
HEP75_RS11600	COG0840	transmembrane signaling receptor activity
HEP75_RS11605	COG0840	transmembrane signaling receptor activity
HEP75_RS11615	COG0745	RESPONSE REGULATOR receiver
HEP75_RS11630	COG1192	Involved in chromosome partitioning
HEP75_RS11635	COG1360	Flagellar Motor Protein
HEP75_RS11640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HEP75_RS11645	COG2198	Histidine kinase
HEP75_RS11645	COG0784	Response regulator, receiver
HEP75_RS11645	COG0643	Histidine kinase
HEP75_RS11695	COG1684	flagellar biosynthetic protein fliR
HEP75_RS11700	COG1987	bacterial-type flagellum assembly
HEP75_RS11710	COG3190	flagellar
HEP75_RS11760	COG1677	Flagellar hook-basal body complex protein FliE
HEP75_RS11790	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS11800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_RS11820	COG2201	protein-glutamate methylesterase activity
HEP75_RS11830	COG2197	response regulator
HEP75_RS11850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HEP75_RS11860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HEP75_RS11865	COG4786	Flagellar basal body rod
HEP75_RS11865	COG1256	bacterial-type flagellum assembly
HEP75_RS11880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HEP75_RS11895	COG1749	Flagellar hook protein flgE
HEP75_RS11900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HEP75_RS11905	COG1558	bacterial-type flagellum-dependent cell motility
HEP75_RS11915	COG0835	chemotaxis
HEP75_RS11915	COG0784	Response regulator, receiver
HEP75_RS11965	COG1116	anion transmembrane transporter activity
HEP75_RS11980	COG2915	High frequency lysogenization protein hflD homolog
HEP75_RS11985	COG0482	sulfurtransferase activity
HEP75_RS12005	COG0542	response to heat
HEP75_RS12025	COG0492	ferredoxin-NADP+ reductase activity
HEP75_RS12030	COG1674	ftsk spoiiie
HEP75_RS12045	COG1230	cation diffusion facilitator family transporter
HEP75_RS12050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEP75_RS12055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP75_RS12075	COG0745	RESPONSE REGULATOR receiver
HEP75_RS12130	COG1595	DNA-templated transcription, initiation
HEP75_RS12150	COG3038	cytochrome b561
HEP75_RS12180	COG2244	polysaccharide biosynthetic process
HEP75_RS12220	COG0297	glycogen (starch) synthase activity
HEP75_RS12225	COG0438	transferase activity, transferring glycosyl groups
HEP75_RS12245	COG1132	(ABC) transporter
HEP75_RS12300	COG1136	(ABC) transporter
HEP75_RS12300	COG0577	efflux transmembrane transporter activity
HEP75_RS12320	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP75_RS12330	COG0714	Associated with various cellular activities
HEP75_RS12345	COG4585	Histidine kinase
HEP75_RS12355	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS12360	COG2197	response regulator
HEP75_RS12405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS12415	COG5000	phosphorelay sensor kinase activity
HEP75_RS12415	COG5002	protein histidine kinase activity
HEP75_RS12480	COG2205	protein histidine kinase activity
HEP75_RS12480	COG0784	Response regulator, receiver
HEP75_RS12485	COG2183	response to ionizing radiation
HEP75_RS12490	COG4191	Histidine kinase
HEP75_RS12490	COG0784	Response regulator, receiver
HEP75_RS12500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_RS12500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEP75_RS12520	COG3243	poly(R)-hydroxyalkanoic acid synthase
HEP75_RS12530	COG1183	phosphatidylcholine synthase activity
HEP75_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS12560	COG0668	transmembrane transport
HEP75_RS12565	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP75_RS12580	COG1914	H( )-stimulated, divalent metal cation uptake system
HEP75_RS12590	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEP75_RS12600	COG0784	Response regulator, receiver
HEP75_RS12600	COG4191	Histidine kinase
HEP75_RS12605	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP75_RS12610	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP75_RS12615	COG1538	Outer membrane efflux protein
HEP75_RS12620	COG1309	transcriptional regulator
HEP75_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS12670	COG0519	Catalyzes the synthesis of GMP from XMP
HEP75_RS12670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP75_RS12680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP75_RS12695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP75_RS12695	COG0475	glutathione-regulated potassium exporter activity
HEP75_RS12700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP75_RS12710	COG0746	molybdenum cofactor guanylyltransferase activity
HEP75_RS12720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP75_RS12740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP75_RS12755	COG1024	Enoyl-CoA hydratase
HEP75_RS12755	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP75_RS12760	COG0183	Belongs to the thiolase family
HEP75_RS12765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP75_RS12780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEP75_RS12790	COG0776	regulation of translation
HEP75_RS12795	COG0539	negative regulation of cytoplasmic translation
HEP75_RS12800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP75_RS12815	COG2957	Belongs to the agmatine deiminase family
HEP75_RS12820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP75_RS12845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS12865	COG0316	Belongs to the HesB IscA family
HEP75_RS12865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEP75_RS12880	COG0428	transporter
HEP75_RS12885	COG3064	Membrane
HEP75_RS12895	COG1530	ribonuclease E activity
HEP75_RS12910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP75_RS12920	COG0582	viral genome integration into host DNA
HEP75_RS12975	COG0583	DNA-binding transcription factor activity
HEP75_RS12995	COG0077	Prephenate dehydratase
HEP75_RS12995	COG1605	Chorismate mutase
HEP75_RS13000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP75_RS13005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP75_RS13010	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HEP75_RS13045	COG4221	oxidoreductase activity
HEP75_RS13075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP75_RS13120	COG4993	Dehydrogenase
HEP75_RS13130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP75_RS13140	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HEP75_RS13145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP75_RS13150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP75_RS13180	COG2977	Belongs to the P-Pant transferase superfamily
HEP75_RS13185	COG0316	Belongs to the HesB IscA family
HEP75_RS13210	COG2197	response regulator
HEP75_RS13255	COG0288	reversible hydration of carbon dioxide
HEP75_RS13270	COG3844	kynureninase activity
HEP75_RS13280	COG2925	Exonuclease
HEP75_RS13315	COG2902	Dehydrogenase
HEP75_RS13325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS13330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_RS13335	COG1960	acyl-CoA dehydrogenase activity
HEP75_RS13340	COG2226	methyltransferase
HEP75_RS13345	COG1410	methionine synthase
HEP75_RS13345	COG0646	methionine synthase
HEP75_RS13350	COG0646	methionine synthase
HEP75_RS13350	COG1410	methionine synthase
HEP75_RS13360	COG2755	lipolytic protein G-D-S-L family
HEP75_RS13360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP75_RS13370	COG2900	Belongs to the SlyX family
HEP75_RS13385	COG0386	Belongs to the glutathione peroxidase family
HEP75_RS13395	COG1725	Transcriptional regulator
HEP75_RS13400	COG1131	(ABC) transporter
HEP75_RS13445	COG2885	chlorophyll binding
HEP75_RS13450	COG2850	peptidyl-arginine hydroxylation
HEP75_RS13505	COG1132	(ABC) transporter
HEP75_RS13515	COG0287	Prephenate dehydrogenase
HEP75_RS13515	COG1605	Chorismate mutase
HEP75_RS13520	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HEP75_RS13535	COG0484	heat shock protein binding
HEP75_RS13540	COG0443	Heat shock 70 kDa protein
HEP75_RS13545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP75_RS13550	COG1420	regulation of RNA biosynthetic process
HEP75_RS13555	COG0497	DNA recombination
HEP75_RS13560	COG0735	belongs to the Fur family
HEP75_RS13565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP75_RS13580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP75_RS13585	COG1404	Belongs to the peptidase S8 family
HEP75_RS13605	COG0583	DNA-binding transcription factor activity
HEP75_RS13610	COG3706	GGDEF domain
HEP75_RS13645	COG3300	MHYT domain
HEP75_RS13645	COG5001	Diguanylate cyclase
HEP75_RS13650	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP75_RS13675	COG0195	Participates in both transcription termination and antitermination
HEP75_RS13690	COG1007	ATP synthesis coupled electron transport
HEP75_RS13725	COG1034	ATP synthesis coupled electron transport
HEP75_RS13730	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP75_RS13735	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HEP75_RS13740	COG0649	NAD binding
HEP75_RS13745	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP75_RS13755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP75_RS13770	COG0149	triose-phosphate isomerase activity
HEP75_RS13775	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS13790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP75_RS13845	COG0101	tRNA pseudouridine synthase activity
HEP75_RS13855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEP75_RS13870	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP75_RS13880	COG0688	phosphatidylethanolamine metabolic process
HEP75_RS13885	COG0741	lytic transglycosylase activity
HEP75_RS13890	COG0433	COG0433 Predicted ATPase
HEP75_RS13895	COG0494	nUDIX hydrolase
HEP75_RS13910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP75_RS13940	COG0717	Belongs to the dCTP deaminase family
HEP75_RS13945	COG0489	protein tyrosine kinase activity
HEP75_RS13950	COG4771	TonB-dependent receptor
HEP75_RS13955	COG0457	Tetratricopeptide repeat
HEP75_RS13965	COG3590	peptidase
HEP75_RS13975	COG0705	Rhomboid family
HEP75_RS13985	COG0697	spore germination
HEP75_RS13995	COG2311	Membrane
HEP75_RS14000	COG1047	Peptidyl-prolyl cis-trans
HEP75_RS14005	COG0791	NLP P60 protein
HEP75_RS14010	COG0791	NLP P60 protein
HEP75_RS14015	COG1607	acyl-coa hydrolase
HEP75_RS14020	COG4106	trans-aconitate 2-methyltransferase activity
HEP75_RS14025	COG1301	dicarboxylic acid transport
HEP75_RS14030	COG1785	Belongs to the alkaline phosphatase family
HEP75_RS14040	COG0037	tRNA processing
HEP75_RS14045	COG1722	exodeoxyribonuclease VII activity
HEP75_RS14050	COG0142	geranyltranstransferase activity
HEP75_RS14060	COG4104	PAAR repeat-containing protein
HEP75_RS14095	COG0312	modulator of DNA gyrase
HEP75_RS14105	COG0312	modulator of DNA gyrase
HEP75_RS14125	COG2968	Membrane
HEP75_RS14140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEP75_RS14155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP75_RS14170	COG0495	leucyl-tRNA aminoacylation
HEP75_RS14180	COG3118	belongs to the thioredoxin family
HEP75_RS14200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEP75_RS14210	COG2040	homocysteine
HEP75_RS14220	COG0346	lactoylglutathione lyase activity
HEP75_RS14240	COG2878	Part of a membrane complex involved in electron transport
HEP75_RS14255	COG1595	DNA-templated transcription, initiation
HEP75_RS14280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP75_RS14300	COG0251	oxidation-reduction process
HEP75_RS14310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP75_RS14310	COG0392	lysyltransferase activity
HEP75_RS14345	COG2814	Major facilitator Superfamily
HEP75_RS14350	COG1902	pentaerythritol trinitrate reductase activity
HEP75_RS14360	COG0583	DNA-binding transcription factor activity
HEP75_RS14375	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP75_RS14385	COG1047	Peptidyl-prolyl cis-trans
HEP75_RS14390	COG1077	Cell shape determining protein MreB Mrl
HEP75_RS14425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEP75_RS14435	COG1451	nucleotide metabolic process
HEP75_RS14455	COG2205	protein histidine kinase activity
HEP75_RS14465	COG2186	Transcriptional regulator
HEP75_RS14470	COG3250	beta-galactosidase activity
HEP75_RS14530	COG1703	isobutyryl-CoA mutase activity
HEP75_RS14530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP75_RS14530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP75_RS14555	COG0183	Belongs to the thiolase family
HEP75_RS14565	COG0443	Heat shock 70 kDa protein
HEP75_RS14595	COG1960	acyl-CoA dehydrogenase activity
HEP75_RS14600	COG1793	dna ligase
HEP75_RS14600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP75_RS14605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP75_RS14605	COG1793	dna ligase
HEP75_RS14610	COG1201	RNA secondary structure unwinding
HEP75_RS14620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP75_RS14625	COG1278	Cold shock
HEP75_RS14630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP75_RS14635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEP75_RS14640	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_RS14650	COG2954	triphosphatase activity
HEP75_RS14660	COG0745	RESPONSE REGULATOR receiver
HEP75_RS14665	COG1381	Involved in DNA repair and RecF pathway recombination
HEP75_RS14670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP75_RS14685	COG0681	Belongs to the peptidase S26 family
HEP75_RS14690	COG0481	GTPase activity
HEP75_RS14695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP75_RS14710	COG1024	Enoyl-CoA hydratase
HEP75_RS14710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP75_RS14730	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS14735	COG2855	membrane
HEP75_RS14750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HEP75_RS14755	COG3250	beta-galactosidase activity
HEP75_RS14760	COG3540	Alkaline phosphatase
HEP75_RS14785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEP75_RS14800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HEP75_RS14815	COG0534	Mate efflux family protein
HEP75_RS14820	COG0335	large ribosomal subunit rRNA binding
HEP75_RS14825	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP75_RS14830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP75_RS14835	COG0228	four-way junction DNA binding
HEP75_RS14845	COG2070	2-Nitropropane dioxygenase
HEP75_RS14850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEP75_RS14875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP75_RS14895	COG0475	glutathione-regulated potassium exporter activity
HEP75_RS14915	COG0625	glutathione transferase activity
HEP75_RS14920	COG1082	Xylose isomerase domain protein TIM barrel
HEP75_RS14930	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP75_RS14935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP75_RS14940	COG1129	ABC transporter
HEP75_RS14945	COG1879	ABC-type sugar transport system periplasmic component
HEP75_RS14950	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_RS14965	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS14970	COG0129	dihydroxy-acid dehydratase activity
HEP75_RS15005	COG3152	Membrane
HEP75_RS15025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEP75_RS15030	COG1845	cytochrome c oxidase, subunit III
HEP75_RS15035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP75_RS15045	COG2964	Protein conserved in bacteria
HEP75_RS15060	COG4771	TonB-dependent receptor
HEP75_RS15085	COG0251	oxidation-reduction process
HEP75_RS15115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP75_RS15130	COG0196	riboflavin kinase activity
HEP75_RS15135	COG0728	peptidoglycan biosynthetic process
HEP75_RS15145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP75_RS15150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP75_RS15155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP75_RS15160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP75_RS15165	COG0824	Thioesterase
HEP75_RS15175	COG1024	Enoyl-CoA hydratase
HEP75_RS15175	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP75_RS15180	COG1946	Acyl-CoA thioesterase
HEP75_RS15195	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HEP75_RS15210	COG0840	transmembrane signaling receptor activity
HEP75_RS15230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HEP75_RS15235	COG4638	Rieske (2fe-2S)
HEP75_RS15260	COG1073	alpha beta
HEP75_RS15285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEP75_RS15305	COG4585	Histidine kinase
HEP75_RS15320	COG2894	cell division
HEP75_RS15325	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEP75_RS15335	COG2205	protein histidine kinase activity
HEP75_RS15340	COG0745	RESPONSE REGULATOR receiver
HEP75_RS15350	COG2194	sulfuric ester hydrolase activity
HEP75_RS15370	COG3209	COG3209 Rhs family protein
HEP75_RS15390	COG2814	Major facilitator Superfamily
HEP75_RS15405	COG5001	Diguanylate cyclase
HEP75_RS15405	COG3706	GGDEF domain
HEP75_RS15405	COG2203	Gaf domain
HEP75_RS15405	COG4251	negative regulation of phosphorylation
HEP75_RS15410	COG0753	catalase activity
HEP75_RS15435	COG1063	alcohol dehydrogenase
HEP75_RS15445	COG3459	Glycosyltransferase 36 associated
HEP75_RS15450	COG2186	Transcriptional regulator
HEP75_RS15470	COG2271	Major facilitator Superfamily
HEP75_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS15515	COG1064	alcohol dehydrogenase
HEP75_RS15550	COG0492	ferredoxin-NADP+ reductase activity
HEP75_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS15585	COG3387	PFAM Glycoside hydrolase 15-related
HEP75_RS15595	COG3275	phosphorelay sensor kinase activity
HEP75_RS15655	COG1196	nuclear chromosome segregation
HEP75_RS15715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP75_RS15725	COG0330	HflC and HflK could
HEP75_RS15730	COG0330	HflC and HflK could
HEP75_RS15735	COG0604	alcohol dehydrogenase
HEP75_RS15755	COG0678	peroxiredoxin activity
HEP75_RS15765	COG4953	penicillin-binding protein 1C
HEP75_RS15770	COG1349	DNA-binding transcription factor activity
HEP75_RS15780	COG2223	nitrite transmembrane transporter activity
HEP75_RS15810	COG0577	efflux transmembrane transporter activity
HEP75_RS15810	COG1136	(ABC) transporter
HEP75_RS15830	COG2373	Large extracellular alpha-helical protein
HEP75_RS15880	COG0372	Belongs to the citrate synthase family
HEP75_RS15895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP75_RS15945	COG2161	toxin-antitoxin pair type II binding
HEP75_RS15950	COG4115	mRNA cleavage
HEP75_RS15970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP75_RS15975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP75_RS15980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP75_RS15990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP75_RS15995	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS16000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEP75_RS16005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_RS16015	COG1399	metal-binding, possibly nucleic acid-binding protein
HEP75_RS16040	COG0714	Associated with various cellular activities
HEP75_RS16060	COG0537	adenosine 5'-monophosphoramidase activity
HEP75_RS16090	COG0314	molybdopterin synthase activity
HEP75_RS16095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEP75_RS16100	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP75_RS16110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP75_RS16115	COG1234	tRNA 3'-trailer cleavage
HEP75_RS16125	COG0859	PFAM glycosyl transferase family 9
HEP75_RS16145	COG0631	protein serine/threonine phosphatase activity
HEP75_RS16150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP75_RS16165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP75_RS16170	COG1388	LysM domain
HEP75_RS16170	COG3942	CHAP domain
HEP75_RS16210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP75_RS16220	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP75_RS16265	COG0473	3-isopropylmalate dehydrogenase activity
HEP75_RS16280	COG4783	chaperone-mediated protein folding
HEP75_RS16295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP75_RS16300	COG0248	Ppx GppA phosphatase
HEP75_RS16305	COG0438	transferase activity, transferring glycosyl groups
HEP75_RS16315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP75_RS16325	COG3291	Pkd domain containing protein
HEP75_RS16330	COG2833	Protein of unknown function (DUF455)
HEP75_RS16350	COG0285	dihydrofolate synthase activity
HEP75_RS16355	COG0588	phosphoglycerate mutase activity
HEP75_RS16375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEP75_RS16380	COG4208	sulfate ABC transporter
HEP75_RS16385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEP75_RS16390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEP75_RS16415	COG2885	chlorophyll binding
HEP75_RS16420	COG0583	DNA-binding transcription factor activity
HEP75_RS16425	COG2814	Major facilitator Superfamily
HEP75_RS16435	COG0667	Aldo Keto reductase
HEP75_RS16445	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP75_RS16445	COG1902	pentaerythritol trinitrate reductase activity
HEP75_RS16485	COG0625	glutathione transferase activity
HEP75_RS16495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP75_RS16515	COG0039	L-malate dehydrogenase activity
HEP75_RS16525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP75_RS16530	COG1217	gtp-binding protein TYPA
HEP75_RS16540	COG0154	amidase activity
HEP75_RS16550	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP75_RS16560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HEP75_RS16565	COG0203	ribosomal protein L17
HEP75_RS16575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP75_RS16590	COG0201	protein transport
HEP75_RS16600	COG1841	ribosomal large subunit assembly
HEP75_RS16630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP75_RS16635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP75_RS16645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP75_RS16650	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP75_RS16675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP75_RS16680	COG0089	rRNA binding
HEP75_RS16685	COG0088	Forms part of the polypeptide exit tunnel
HEP75_RS16695	COG0051	transcription antitermination factor activity, RNA binding
HEP75_RS16700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP75_RS16705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP75_RS16720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP75_RS16730	COG0222	ribosome binding
HEP75_RS16745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP75_RS16750	COG0250	Participates in transcription elongation, termination and antitermination
HEP75_RS16765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP75_RS16785	COG0012	GTP binding
HEP75_RS16790	COG0193	aminoacyl-tRNA hydrolase activity
HEP75_RS16800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP75_RS16810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP75_RS16825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP75_RS16830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP75_RS16845	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP75_RS16860	COG1254	Belongs to the acylphosphatase family
HEP75_RS16865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP75_RS16870	COG1295	ribonuclease BN
HEP75_RS16890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP75_RS16895	COG1404	Belongs to the peptidase S8 family
HEP75_RS16900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP75_RS16905	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP75_RS16960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP75_RS16960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP75_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS16970	COG0583	DNA-binding transcription factor activity
HEP75_RS17000	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP75_RS17010	COG3634	alkyl hydroperoxide reductase activity
HEP75_RS17015	COG0583	DNA-binding transcription factor activity
HEP75_RS17025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP75_RS17030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP75_RS17050	COG2197	response regulator
HEP75_RS17075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP75_RS17085	COG0697	spore germination
HEP75_RS17135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP75_RS17140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP75_RS17150	COG2096	Adenosyltransferase
HEP75_RS17165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEP75_RS17170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEP75_RS17180	COG2967	ApaG domain
HEP75_RS17185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP75_RS17220	COG1704	LemA family
HEP75_RS17225	COG0861	Integral membrane protein TerC family
HEP75_RS17230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEP75_RS17245	COG2205	protein histidine kinase activity
HEP75_RS17265	COG0642	Histidine kinase
HEP75_RS17280	COG4181	ATPase activity
HEP75_RS17285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEP75_RS17305	COG4771	TonB-dependent receptor
HEP75_RS17315	COG0667	Aldo Keto reductase
HEP75_RS17320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEP75_RS17340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP75_RS17360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP75_RS17365	COG4305	rare lipoprotein A
HEP75_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS17385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP75_RS17395	COG4191	Histidine kinase
HEP75_RS17400	COG0784	Response regulator, receiver
HEP75_RS17405	COG2205	protein histidine kinase activity
HEP75_RS17405	COG2202	Pas domain
HEP75_RS17415	COG2823	Periplasmic or secreted lipoprotein
HEP75_RS17420	COG0673	inositol 2-dehydrogenase activity
HEP75_RS17425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP75_RS17435	COG1090	epimerase
HEP75_RS17465	COG1051	belongs to the nudix hydrolase family
HEP75_RS17465	COG1056	cytidyltransferase-related domain
HEP75_RS17495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP75_RS17500	COG0321	lipoyl(octanoyl) transferase activity
HEP75_RS17515	COG1686	Belongs to the peptidase S11 family
HEP75_RS17525	COG2951	lytic endotransglycosylase activity
HEP75_RS17535	COG0772	Belongs to the SEDS family
HEP75_RS17540	COG0768	penicillin binding
HEP75_RS17550	COG1792	Involved in formation and maintenance of cell shape
HEP75_RS17555	COG1077	Cell shape determining protein MreB Mrl
HEP75_RS17560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP75_RS17565	COG3284	Transcriptional regulator
HEP75_RS17575	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP75_RS17585	COG2010	Cytochrome c
HEP75_RS17610	COG0596	Alpha beta hydrolase
HEP75_RS17610	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP75_RS17615	COG0308	aminopeptidase N
HEP75_RS17620	COG2226	methyltransferase
HEP75_RS17655	COG0494	nUDIX hydrolase
HEP75_RS17670	COG0739	heme binding
HEP75_RS17680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEP75_RS17685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP75_RS17695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEP75_RS17700	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP75_RS17710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP75_RS17725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEP75_RS17740	COG3116	cell division
HEP75_RS17745	COG0275	rRNA processing
HEP75_RS17750	COG2001	Belongs to the MraZ family
HEP75_RS17780	COG1988	membrane-bound metal-dependent
HEP75_RS17785	COG0277	FAD linked oxidase domain protein
HEP75_RS17790	COG0745	RESPONSE REGULATOR receiver
HEP75_RS17795	COG2205	protein histidine kinase activity
HEP75_RS17805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP75_RS17810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP75_RS17830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEP75_RS17835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP75_RS17840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP75_RS17855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP75_RS17855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP75_RS17865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP75_RS17890	COG0477	Major facilitator Superfamily
HEP75_RS17895	COG0488	(ABC) transporter
HEP75_RS17900	COG0242	peptide deformylase activity
HEP75_RS17910	COG1960	acyl-CoA dehydrogenase activity
HEP75_RS17920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP75_RS17930	COG1696	Membrane protein involved in D-alanine export
HEP75_RS17950	COG1215	transferase activity, transferring glycosyl groups
HEP75_RS17960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEP75_RS17965	COG0457	Tetratricopeptide repeat
HEP75_RS17970	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEP75_RS17975	COG1215	transferase activity, transferring glycosyl groups
HEP75_RS17980	COG1215	transferase activity, transferring glycosyl groups
HEP75_RS18040	COG2188	Transcriptional regulator
HEP75_RS18055	COG1450	Type ii and iii secretion system protein
HEP75_RS18070	COG3166	PFAM Fimbrial assembly family protein
HEP75_RS18075	COG3156	type II secretion system protein K
HEP75_RS18080	COG4795	General secretion pathway protein
HEP75_RS18085	COG2165	general secretion pathway protein
HEP75_RS18090	COG4970	Tfp pilus assembly protein FimT
HEP75_RS18095	COG2165	general secretion pathway protein
HEP75_RS18100	COG1459	type II secretion system
HEP75_RS18105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP75_RS18115	COG1404	Belongs to the peptidase S8 family
HEP75_RS18120	COG5295	Hep Hag repeat protein
HEP75_RS18135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP75_RS18135	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP75_RS18140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP75_RS18145	COG4974	Belongs to the 'phage' integrase family
HEP75_RS18170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP75_RS18205	COG1183	phosphatidylcholine synthase activity
HEP75_RS18215	COG0442	prolyl-tRNA aminoacylation
HEP75_RS18230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP75_RS18235	COG1127	ABC transporter
HEP75_RS18240	COG3218	ABC-type transport auxiliary lipoprotein component
HEP75_RS18240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP75_RS18275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP75_RS18280	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HEP75_RS18280	COG0662	Cupin 2, conserved barrel domain protein
HEP75_RS18305	COG2086	electron transfer activity
HEP75_RS18320	COG0546	phosphoglycolate phosphatase activity
HEP75_RS18320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP75_RS18325	COG0277	FAD linked oxidase domain protein
HEP75_RS18330	COG0300	oxidoreductase activity
HEP75_RS18335	COG2226	methyltransferase
HEP75_RS18340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_RS18370	COG2226	methyltransferase
HEP75_RS18380	COG3754	Rhamnan synthesis protein F
HEP75_RS18385	COG1216	Glycosyl transferase, family 2
HEP75_RS18385	COG0438	transferase activity, transferring glycosyl groups
HEP75_RS18405	COG0626	cystathionine gamma-synthase activity
HEP75_RS18435	COG0625	glutathione transferase activity
HEP75_RS18445	COG0513	Belongs to the DEAD box helicase family
HEP75_RS18450	COG0720	synthase
HEP75_RS18460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP75_RS18465	COG1956	GAF domain-containing protein
HEP75_RS18475	COG4206	TonB-dependent receptor
HEP75_RS18480	COG0546	phosphoglycolate phosphatase activity
HEP75_RS18500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP75_RS18520	COG0339	signal peptide processing
HEP75_RS18525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP75_RS18535	COG2217	Heavy metal translocating P-type atpase
HEP75_RS18550	COG2132	Multicopper oxidase
HEP75_RS18575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP75_RS18585	COG1136	(ABC) transporter
HEP75_RS18590	COG0577	efflux transmembrane transporter activity
HEP75_RS18595	COG0577	efflux transmembrane transporter activity
HEP75_RS18600	COG0577	efflux transmembrane transporter activity
HEP75_RS18605	COG0577	efflux transmembrane transporter activity
HEP75_RS18610	COG0577	efflux transmembrane transporter activity
HEP75_RS18610	COG1136	(ABC) transporter
HEP75_RS18615	COG1136	(ABC) transporter
HEP75_RS18615	COG0577	efflux transmembrane transporter activity
HEP75_RS18625	COG0577	efflux transmembrane transporter activity
HEP75_RS18625	COG1136	(ABC) transporter
HEP75_RS18640	COG4191	Histidine kinase
HEP75_RS18650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP75_RS18665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP75_RS18680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP75_RS18690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP75_RS18700	COG0356	it plays a direct role in the translocation of protons across the membrane
HEP75_RS18720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP75_RS18725	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP75_RS18760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP75_RS18765	COG0697	spore germination
HEP75_RS18770	COG1666	GTP binding
HEP75_RS18780	COG1187	pseudouridine synthase activity
HEP75_RS18805	COG2205	protein histidine kinase activity
HEP75_RS18805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP75_RS18830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_RS18890	COG0842	Transport permease protein
HEP75_RS18895	COG1131	(ABC) transporter
HEP75_RS18900	COG0025	NhaP-type Na H and K H
HEP75_RS18910	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEP75_RS18915	COG1573	uracil-dna glycosylase
HEP75_RS18925	COG3384	dioxygenase
HEP75_RS18945	COG0667	Aldo Keto reductase
HEP75_RS18950	COG0667	Aldo Keto reductase
HEP75_RS18965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_RS18970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_RS19000	COG5001	Diguanylate cyclase
HEP75_RS19030	COG3275	phosphorelay sensor kinase activity
HEP75_RS19055	COG0531	amino acid
HEP75_RS19075	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_RS19075	COG5297	Belongs to the glycosyl hydrolase family 6
HEP75_RS19080	COG0612	Peptidase, M16
HEP75_RS19105	COG0741	lytic transglycosylase activity
HEP75_RS19135	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP75_RS19140	COG2207	Transcriptional regulator
HEP75_RS19150	COG0598	Magnesium transport protein CorA
HEP75_RS19155	COG1113	amino acid transport
HEP75_RS19165	COG0697	spore germination
HEP75_RS19200	COG2409	Drug exporters of the RND superfamily
HEP75_RS19205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP75_RS19215	COG5520	Belongs to the glycosyl hydrolase 30 family
HEP75_RS19370	COG0584	glycerophosphoryl diester phosphodiesterase
HEP75_RS19395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP75_RS19410	COG2827	Endonuclease containing a URI domain
HEP75_RS19415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEP75_RS19440	COG1595	DNA-templated transcription, initiation
HEP75_RS19445	COG0459	protein refolding
HEP75_RS19455	COG2356	endonuclease I
HEP75_RS19460	COG1324	tolerance protein
HEP75_RS19470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP75_RS19485	COG1733	regulation of RNA biosynthetic process
HEP75_RS19490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP75_RS19495	COG0511	ligase activity, forming carbon-carbon bonds
HEP75_RS19505	COG0439	Biotin carboxylase
HEP75_RS19515	COG0300	oxidoreductase activity
HEP75_RS19530	COG2264	protein methyltransferase activity
HEP75_RS19550	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HEP75_RS19555	COG4589	Belongs to the CDS family
HEP75_RS19580	COG0671	phosphoesterase, PA-phosphatase related
HEP75_RS19580	COG2453	phosphatase
HEP75_RS19585	COG2267	carboxylic ester hydrolase activity
HEP75_RS19590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP75_RS19595	COG0138	bifunctional purine biosynthesis protein purh
HEP75_RS19605	COG0151	Belongs to the GarS family
HEP75_RS19615	COG1289	transmembrane transporter activity
HEP75_RS19620	COG2814	Major facilitator Superfamily
HEP75_RS19705	COG2906	2 iron, 2 sulfur cluster binding
HEP75_RS19735	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HEP75_RS19750	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HEP75_RS19755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP75_RS19760	COG0730	response to heat
HEP75_RS19770	COG0134	indole-3-glycerol-phosphate synthase activity
HEP75_RS19780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP75_RS19810	COG1597	lipid kinase activity
HEP75_RS19825	COG0484	heat shock protein binding
HEP75_RS19835	COG2814	Major facilitator Superfamily
HEP75_RS19840	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HEP75_RS19860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_RS19865	COG2111	Na H antiporter
HEP75_RS19865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP75_RS19870	COG1006	Multisubunit Na H antiporter MnhC subunit
HEP75_RS19875	COG0651	ATP synthesis coupled electron transport
HEP75_RS19885	COG2212	antiporter activity
HEP75_RS19890	COG1320	monovalent cation:proton antiporter activity
HEP75_RS19915	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP75_RS19920	COG2852	Protein conserved in bacteria
HEP75_RS19940	COG3104	oligopeptide transport
HEP75_RS19945	COG3483	tryptophan 2,3-dioxygenase activity
HEP75_RS19960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP75_RS19985	COG3227	Zinc metalloprotease (Elastase)
HEP75_RS19990	COG0513	Belongs to the DEAD box helicase family
HEP75_RS20000	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS20010	COG0702	epimerase
HEP75_RS20015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP75_RS20025	COG2354	Protein conserved in bacteria
HEP75_RS20040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP75_RS20050	COG1196	nuclear chromosome segregation
HEP75_RS20050	COG3264	Mechanosensitive ion channel
HEP75_RS20055	COG0604	alcohol dehydrogenase
HEP75_RS20055	COG3321	synthase
HEP75_RS20055	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS20075	COG1595	DNA-templated transcription, initiation
HEP75_RS20090	COG0477	Major facilitator Superfamily
HEP75_RS20095	COG1802	Transcriptional regulator
HEP75_RS20110	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HEP75_RS20145	COG1414	Transcriptional regulator
HEP75_RS20150	COG0738	Major facilitator superfamily
HEP75_RS20155	COG3254	rhamnose metabolic process
HEP75_RS20160	COG4948	Mandelate Racemase Muconate Lactonizing
HEP75_RS20165	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP75_RS20170	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS20210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP75_RS20225	COG4807	Protein conserved in bacteria
HEP75_RS20280	COG5507	3-demethylubiquinone-9 3-methyltransferase
HEP75_RS20285	COG4773	Receptor
HEP75_RS20315	COG3220	belongs to the UPF0276 family
HEP75_RS20410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP75_RS20440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP75_RS20445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP75_RS20460	COG0753	catalase activity
HEP75_RS20475	COG4773	Receptor
HEP75_RS20480	COG2197	response regulator
HEP75_RS20485	COG4585	Histidine kinase
HEP75_RS20495	COG1131	(ABC) transporter
HEP75_RS20500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_RS20505	COG1136	(ABC) transporter
HEP75_RS20510	COG0577	efflux transmembrane transporter activity
HEP75_RS20525	COG2962	Rard protein
HEP75_RS20530	COG0697	spore germination
HEP75_RS20535	COG2133	pyrroloquinoline quinone binding
HEP75_RS20545	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_RS20550	COG0583	DNA-binding transcription factor activity
HEP75_RS20565	COG0180	Tryptophanyl-tRNA synthetase
HEP75_RS20575	COG3237	CsbD-like
HEP75_RS20610	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HEP75_RS20610	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HEP75_RS20650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP75_RS20655	COG3604	Transcriptional regulator
HEP75_RS20690	COG1222	aaa ATPase
HEP75_RS20790	COG2084	Dehydrogenase
HEP75_RS20795	COG1902	pentaerythritol trinitrate reductase activity
HEP75_RS20830	COG1404	Belongs to the peptidase S8 family
HEP75_RS20835	COG2814	Major facilitator Superfamily
HEP75_RS20840	COG0583	DNA-binding transcription factor activity
HEP75_RS20860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP75_RS20865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP75_RS20895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP75_RS20900	COG1764	response to oxidative stress
HEP75_RS20905	COG1846	Transcriptional regulator
HEP75_RS20910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEP75_RS20920	COG0697	spore germination
HEP75_RS20925	COG0523	cobalamin synthesis protein
HEP75_RS20940	COG3245	cytochrome
HEP75_RS20950	COG1960	acyl-CoA dehydrogenase activity
HEP75_RS20955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP75_RS21020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP75_RS21025	COG3387	PFAM Glycoside hydrolase 15-related
HEP75_RS21030	COG0745	RESPONSE REGULATOR receiver
HEP75_RS21045	COG1404	Belongs to the peptidase S8 family
HEP75_RS21055	COG3100	YcgL domain-containing protein
HEP75_RS21060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP75_RS21070	COG0463	Glycosyl transferase, family 2
HEP75_RS21115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP75_RS21130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP75_RS21155	COG1294	oxidase, subunit
HEP75_RS21160	COG1271	oxidase subunit
HEP75_RS21180	COG0408	coproporphyrinogen oxidase activity
HEP75_RS21190	COG2323	membrane
HEP75_RS21235	COG0515	serine threonine protein kinase
HEP75_RS21240	COG0631	protein serine/threonine phosphatase activity
HEP75_RS21350	COG0589	response to stress
HEP75_RS21375	COG3275	phosphorelay sensor kinase activity
HEP75_RS21380	COG3279	Response regulator of the LytR AlgR family
HEP75_RS21390	COG0210	DNA helicase
HEP75_RS21470	COG0463	Glycosyl transferase, family 2
HEP75_RS21480	COG1475	DNA binding
HEP75_RS21485	COG1192	Involved in chromosome partitioning
HEP75_RS21490	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP75_RS21495	COG2091	lysine biosynthetic process via aminoadipic acid
HEP75_RS21520	COG1011	Hydrolase
HEP75_RS21525	COG0477	Major facilitator Superfamily
HEP75_RS21545	COG1971	Probably functions as a manganese efflux pump
HEP75_RS21560	COG0457	Tetratricopeptide repeat
HEP75_RS21565	COG2205	protein histidine kinase activity
HEP75_RS21575	COG5001	Diguanylate cyclase
HEP75_RS21580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP75_RS21585	COG3459	Glycosyltransferase 36 associated
HEP75_RS21590	COG2211	Major facilitator Superfamily
HEP75_RS21595	COG3265	gluconokinase activity
HEP75_RS21600	COG2155	Conserved Protein
HEP75_RS21605	COG2094	Belongs to the DNA glycosylase MPG family
HEP75_RS21620	COG2911	Protein conserved in bacteria
HEP75_RS21625	COG0729	surface antigen
HEP75_RS21640	COG3132	Protein of unknown function, DUF480
HEP75_RS21675	COG3210	domain, Protein
HEP75_RS21690	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HEP75_RS21695	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP75_RS21725	COG2937	Belongs to the GPAT DAPAT family
HEP75_RS21745	COG2211	Major facilitator Superfamily
HEP75_RS21760	COG3693	PFAM glycoside hydrolase, family 10
HEP75_RS21770	COG3250	beta-galactosidase activity
HEP75_RS21790	COG3386	PFAM SMP-30 Gluconolaconase
HEP75_RS21800	COG0667	Aldo Keto reductase
HEP75_RS21805	COG0583	DNA-binding transcription factor activity
HEP75_RS21870	COG0246	Mannitol dehydrogenase
HEP75_RS21875	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_RS21885	COG4948	Mandelate Racemase Muconate Lactonizing
HEP75_RS21895	COG3661	Belongs to the glycosyl hydrolase 67 family
HEP75_RS21905	COG2115	Belongs to the xylose isomerase family
HEP75_RS21915	COG0037	tRNA processing
HEP75_RS21930	COG0840	transmembrane signaling receptor activity
HEP75_RS21940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEP75_RS21950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP75_RS21960	COG0805	protein transport
HEP75_RS21970	COG0519	Catalyzes the synthesis of GMP from XMP
HEP75_RS21970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP75_RS21980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP75_RS21995	COG0210	DNA helicase
HEP75_RS22000	COG1435	thymidine kinase activity
HEP75_RS22010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEP75_RS22025	COG0515	serine threonine protein kinase
HEP75_RS22025	COG2815	serine threonine protein kinase
HEP75_RS22035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP75_RS22055	COG1119	ATPase activity
HEP75_RS22070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HEP75_RS22080	COG1335	isochorismatase
HEP75_RS22100	COG1733	regulation of RNA biosynthetic process
HEP75_RS22120	COG0706	membrane insertase activity
HEP75_RS22125	COG0594	ribonuclease P activity