locus-tag	class	description
HEP74_RS00010	COG0592	DNA-directed DNA polymerase activity
HEP74_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP74_RS00020	COG0187	DNA topoisomerase II activity
HEP74_RS00025	COG1266	CAAX protease self-immunity
HEP74_RS00030	COG0501	Belongs to the peptidase M48B family
HEP74_RS00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HEP74_RS00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP74_RS00100	COG1280	lysine exporter protein (LysE YggA)
HEP74_RS00125	COG4772	TonB-dependent receptor
HEP74_RS00145	COG3284	Transcriptional regulator
HEP74_RS00150	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_RS00190	COG0277	FAD linked oxidase domain protein
HEP74_RS00195	COG1304	FMN binding
HEP74_RS00200	COG2186	Transcriptional regulator
HEP74_RS00215	COG4585	Histidine kinase
HEP74_RS00220	COG2197	response regulator
HEP74_RS00365	COG4771	TonB-dependent receptor
HEP74_RS00415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEP74_RS00430	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP74_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS00455	COG2755	lipolytic protein G-D-S-L family
HEP74_RS00465	COG3186	Phenylalanine-4-hydroxylase
HEP74_RS00470	COG1522	sequence-specific DNA binding
HEP74_RS00485	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEP74_RS00495	COG1595	DNA-templated transcription, initiation
HEP74_RS00505	COG3220	belongs to the UPF0276 family
HEP74_RS00555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HEP74_RS00590	COG1929	Belongs to the glycerate kinase type-1 family
HEP74_RS00600	COG2814	Major facilitator Superfamily
HEP74_RS00610	COG0531	amino acid
HEP74_RS00615	COG4566	intracellular signal transduction
HEP74_RS00620	COG4191	Histidine kinase
HEP74_RS00635	COG0625	glutathione transferase activity
HEP74_RS00640	COG1322	Protein conserved in bacteria
HEP74_RS00650	COG0386	Belongs to the glutathione peroxidase family
HEP74_RS00660	COG2853	Lipoprotein
HEP74_RS00675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP74_RS00680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP74_RS00685	COG1127	ABC transporter
HEP74_RS00720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEP74_RS00725	COG1074	ATP-dependent DNA helicase activity
HEP74_RS00730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP74_RS00750	COG0537	adenosine 5'-monophosphoramidase activity
HEP74_RS00815	COG0477	Major facilitator Superfamily
HEP74_RS00820	COG0302	gtp cyclohydrolase
HEP74_RS00845	COG0730	response to heat
HEP74_RS00860	COG2951	lytic endotransglycosylase activity
HEP74_RS00885	COG3135	benzoate transporter
HEP74_RS00920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP74_RS00925	COG1803	Methylglyoxal synthase
HEP74_RS00930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP74_RS00935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP74_RS00945	COG0493	'glutamate synthase
HEP74_RS00950	COG0067	glutamate synthase
HEP74_RS00950	COG0070	glutamate synthase
HEP74_RS00950	COG0069	glutamate synthase activity
HEP74_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS01005	COG1111	helicase
HEP74_RS01005	COG1205	dead DEAH box helicase
HEP74_RS01010	COG3549	Plasmid maintenance system killer
HEP74_RS01070	COG2271	Major facilitator Superfamily
HEP74_RS01080	COG0657	acetylesterase activity
HEP74_RS01140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP74_RS01145	COG1192	Involved in chromosome partitioning
HEP74_RS01160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP74_RS01165	COG2050	protein possibly involved in aromatic compounds catabolism
HEP74_RS01185	COG1881	PFAM PEBP family protein
HEP74_RS01195	COG0174	glutamine synthetase
HEP74_RS01200	COG0347	Belongs to the P(II) protein family
HEP74_RS01205	COG0004	ammonium transporteR
HEP74_RS01210	COG3852	Histidine kinase
HEP74_RS01215	COG2204	response regulator
HEP74_RS01220	COG2032	superoxide dismutase activity
HEP74_RS01225	COG2032	superoxide dismutase activity
HEP74_RS01240	COG0183	Belongs to the thiolase family
HEP74_RS01285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP74_RS01315	COG0702	epimerase
HEP74_RS01320	COG0583	DNA-binding transcription factor activity
HEP74_RS01335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEP74_RS01345	COG0612	Peptidase, M16
HEP74_RS01355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_RS01365	COG0596	Alpha beta hydrolase
HEP74_RS01375	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEP74_RS01380	COG0318	PFAM AMP-dependent synthetase and ligase
HEP74_RS01395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_RS01425	COG0564	pseudouridine synthase activity
HEP74_RS01455	COG1595	DNA-templated transcription, initiation
HEP74_RS01460	COG1446	asparaginase
HEP74_RS01465	COG0339	signal peptide processing
HEP74_RS01470	COG0681	Belongs to the peptidase S26 family
HEP74_RS01495	COG0583	DNA-binding transcription factor activity
HEP74_RS01500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP74_RS01505	COG2224	Isocitrate lyase
HEP74_RS01540	COG0659	secondary active sulfate transmembrane transporter activity
HEP74_RS01575	COG0583	DNA-binding transcription factor activity
HEP74_RS01580	COG1959	2 iron, 2 sulfur cluster binding
HEP74_RS01590	COG1690	Belongs to the RtcB family
HEP74_RS01610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP74_RS01615	COG2130	NADP-dependent
HEP74_RS01630	COG1187	pseudouridine synthase activity
HEP74_RS01655	COG0084	hydrolase, TatD family'
HEP74_RS01755	COG0842	Transport permease protein
HEP74_RS01760	COG1131	(ABC) transporter
HEP74_RS01765	COG0543	2 iron, 2 sulfur cluster binding
HEP74_RS01765	COG0633	Ferredoxin
HEP74_RS01770	COG2207	Transcriptional regulator
HEP74_RS01770	COG0662	Cupin 2, conserved barrel domain protein
HEP74_RS01785	COG1476	TRANSCRIPTIONal
HEP74_RS01795	COG4555	ABC transporter
HEP74_RS01815	COG0625	glutathione transferase activity
HEP74_RS01850	COG0028	Belongs to the TPP enzyme family
HEP74_RS01875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_RS01895	COG1199	ATP-dependent helicase activity
HEP74_RS01965	COG0628	permease
HEP74_RS01995	COG2133	pyrroloquinoline quinone binding
HEP74_RS02045	COG5463	Belongs to the UPF0441 family
HEP74_RS02050	COG0754	glutathionylspermidine amidase activity
HEP74_RS02100	COG2831	hemolysin activation secretion protein
HEP74_RS02110	COG0714	Associated with various cellular activities
HEP74_RS02145	COG1522	sequence-specific DNA binding
HEP74_RS02150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEP74_RS02165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS02170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_RS02190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP74_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS02230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP74_RS02240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP74_RS02255	COG2267	carboxylic ester hydrolase activity
HEP74_RS02260	COG0606	chelatase, subunit chli
HEP74_RS02265	COG2960	long-chain fatty acid transporting porin activity
HEP74_RS02290	COG1166	arginine decarboxylase activity
HEP74_RS02295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP74_RS02295	COG2755	lipolytic protein G-D-S-L family
HEP74_RS02305	COG0583	DNA-binding transcription factor activity
HEP74_RS02325	COG4221	oxidoreductase activity
HEP74_RS02345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEP74_RS02355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP74_RS02365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP74_RS02375	COG2814	Major facilitator Superfamily
HEP74_RS02390	COG0739	heme binding
HEP74_RS02395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP74_RS02430	COG1064	alcohol dehydrogenase
HEP74_RS02435	COG2234	aminopeptidase activity
HEP74_RS02445	COG4942	peptidase
HEP74_RS02450	COG0793	Belongs to the peptidase S41A family
HEP74_RS02480	COG0531	amino acid
HEP74_RS02490	COG1486	melibiose metabolic process
HEP74_RS02505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP74_RS02505	COG1565	acr, cog1565
HEP74_RS02515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HEP74_RS02520	COG1845	cytochrome c oxidase, subunit III
HEP74_RS02540	COG1612	heme a metabolic process
HEP74_RS02545	COG0109	protoheme IX farnesyltransferase activity
HEP74_RS02565	COG0358	DNA primase activity
HEP74_RS02570	COG1295	ribonuclease BN
HEP74_RS02575	COG1610	YqeY-like protein
HEP74_RS02590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP74_RS02595	COG2308	Evidence 4 Homologs of previously reported genes of
HEP74_RS02610	COG2133	pyrroloquinoline quinone binding
HEP74_RS02630	COG0531	amino acid
HEP74_RS02640	COG4948	Mandelate Racemase Muconate Lactonizing
HEP74_RS02650	COG4771	TonB-dependent receptor
HEP74_RS02690	COG3409	Peptidoglycan-binding domain 1 protein
HEP74_RS02690	COG3501	Rhs element vgr protein
HEP74_RS02700	COG0477	Major facilitator Superfamily
HEP74_RS02740	COG5383	Protein conserved in bacteria
HEP74_RS02760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS02775	COG1652	LysM domain
HEP74_RS02800	COG0583	DNA-binding transcription factor activity
HEP74_RS02820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP74_RS02825	COG3118	belongs to the thioredoxin family
HEP74_RS02835	COG2884	Cell division ATP-binding protein ftsE
HEP74_RS02840	COG2177	Part of the ABC transporter FtsEX involved in
HEP74_RS02845	COG2201	protein-glutamate methylesterase activity
HEP74_RS02850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP74_RS02855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP74_RS02860	COG2860	membrane
HEP74_RS02865	COG1252	NADH dehydrogenase
HEP74_RS02875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEP74_RS02885	COG0534	Mate efflux family protein
HEP74_RS02890	COG0616	signal peptide processing
HEP74_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS02915	COG0009	L-threonylcarbamoyladenylate synthase
HEP74_RS02920	COG1754	DNA topoisomerase type I activity
HEP74_RS02920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP74_RS02925	COG1714	RDD family
HEP74_RS02940	COG0758	DNA mediated transformation
HEP74_RS02945	COG1652	LysM domain
HEP74_RS02950	COG0242	peptide deformylase activity
HEP74_RS02960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEP74_RS02960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP74_RS02965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP74_RS02980	COG0463	Glycosyl transferase, family 2
HEP74_RS03000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP74_RS03015	COG1490	D-aminoacyl-tRNA deacylase activity
HEP74_RS03020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP74_RS03035	COG1609	Transcriptional regulator
HEP74_RS03040	COG3537	Alpha-1,2-mannosidase
HEP74_RS03045	COG1733	regulation of RNA biosynthetic process
HEP74_RS03055	COG0366	Alpha amylase catalytic
HEP74_RS03060	COG0366	Alpha amylase catalytic
HEP74_RS03065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP74_RS03075	COG1002	Type II restriction enzyme, methylase subunits
HEP74_RS03080	COG1061	Type III restriction enzyme res subunit
HEP74_RS03085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP74_RS03125	COG1309	transcriptional regulator
HEP74_RS03130	COG0604	alcohol dehydrogenase
HEP74_RS03145	COG0024	Methionine aminopeptidase
HEP74_RS03185	COG2207	Transcriptional regulator
HEP74_RS03200	COG1309	transcriptional regulator
HEP74_RS03225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_RS03225	COG2124	cytochrome p450
HEP74_RS03230	COG1309	transcriptional regulator
HEP74_RS03240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP74_RS03245	COG2271	Major facilitator Superfamily
HEP74_RS03270	COG0745	RESPONSE REGULATOR receiver
HEP74_RS03275	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HEP74_RS03275	COG4932	domain protein
HEP74_RS03275	COG3266	domain, Protein
HEP74_RS03295	COG0840	transmembrane signaling receptor activity
HEP74_RS03315	COG3546	catalase activity
HEP74_RS03320	COG3685	Protein conserved in bacteria
HEP74_RS03325	COG3685	Protein conserved in bacteria
HEP74_RS03330	COG0588	phosphoglycerate mutase activity
HEP74_RS03335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP74_RS03340	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS03350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP74_RS03385	COG0028	Belongs to the TPP enzyme family
HEP74_RS03390	COG4191	Histidine kinase
HEP74_RS03395	COG2204	response regulator
HEP74_RS03415	COG1648	precorrin-2 dehydrogenase activity
HEP74_RS03415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP74_RS03425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEP74_RS03425	COG1116	anion transmembrane transporter activity
HEP74_RS03455	COG2223	nitrite transmembrane transporter activity
HEP74_RS03460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP74_RS03465	COG2146	nitrite reductase [NAD(P)H] activity
HEP74_RS03470	COG0243	molybdopterin cofactor binding
HEP74_RS03500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP74_RS03510	COG0297	glycogen (starch) synthase activity
HEP74_RS03520	COG0745	RESPONSE REGULATOR receiver
HEP74_RS03530	COG1335	isochorismatase
HEP74_RS03555	COG0181	hydroxymethylbilane synthase activity
HEP74_RS03570	COG1733	regulation of RNA biosynthetic process
HEP74_RS03585	COG1505	serine-type exopeptidase activity
HEP74_RS03595	COG0436	Aminotransferase
HEP74_RS03605	COG2832	Protein of unknown function (DUF454)
HEP74_RS03640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HEP74_RS03645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP74_RS03650	COG0366	Alpha amylase catalytic
HEP74_RS03665	COG3345	alpha-galactosidase
HEP74_RS03675	COG2222	sugar isomerase
HEP74_RS03700	COG1349	DNA-binding transcription factor activity
HEP74_RS03770	COG3250	beta-galactosidase activity
HEP74_RS03785	COG2188	Transcriptional regulator
HEP74_RS03795	COG1609	Transcriptional regulator
HEP74_RS03800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP74_RS03805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEP74_RS03810	COG3001	Fructosamine kinase
HEP74_RS03835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP74_RS03850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HEP74_RS03860	COG2207	Transcriptional regulator
HEP74_RS03880	COG3738	Protein conserved in bacteria
HEP74_RS03900	COG2205	protein histidine kinase activity
HEP74_RS03925	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP74_RS03930	COG3791	Glutathione-dependent formaldehyde-activating
HEP74_RS03940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP74_RS03950	COG0697	spore germination
HEP74_RS03960	COG1307	EDD domain protein, DegV family
HEP74_RS03975	COG0804	urea catabolic process
HEP74_RS03980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP74_RS03995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP74_RS04020	COG0436	Aminotransferase
HEP74_RS04025	COG1162	GTPase activity
HEP74_RS04050	COG2211	Major facilitator Superfamily
HEP74_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS04065	COG2851	Citrate transporter
HEP74_RS04080	COG0642	Histidine kinase
HEP74_RS04090	COG2205	protein histidine kinase activity
HEP74_RS04090	COG0745	RESPONSE REGULATOR receiver
HEP74_RS04090	COG3292	Two component regulator propeller
HEP74_RS04090	COG3292	Two component regulator propeller
HEP74_RS04090	COG2205	protein histidine kinase activity
HEP74_RS04090	COG0745	RESPONSE REGULATOR receiver
HEP74_RS04105	COG4191	Histidine kinase
HEP74_RS04115	COG1301	dicarboxylic acid transport
HEP74_RS04120	COG0280	phosphate acetyltransferase
HEP74_RS04120	COG0281	malic enzyme
HEP74_RS04145	COG1560	Kdo2-lipid A biosynthetic process
HEP74_RS04150	COG1519	Transferase
HEP74_RS04155	COG1538	Outer membrane efflux protein
HEP74_RS04160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP74_RS04180	COG0473	3-isopropylmalate dehydrogenase activity
HEP74_RS04185	COG0066	3-isopropylmalate dehydratase activity
HEP74_RS04200	COG4106	trans-aconitate 2-methyltransferase activity
HEP74_RS04205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP74_RS04225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP74_RS04235	COG2815	serine threonine protein kinase
HEP74_RS04235	COG0515	serine threonine protein kinase
HEP74_RS04240	COG0405	Gamma-glutamyltransferase
HEP74_RS04245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HEP74_RS04250	COG0840	transmembrane signaling receptor activity
HEP74_RS04265	COG0823	Involved in the tonB-independent uptake of proteins
HEP74_RS04285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP74_RS04295	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP74_RS04330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP74_RS04340	COG0671	phosphoesterase, PA-phosphatase related
HEP74_RS04355	COG1940	carbohydrate kinase activity
HEP74_RS04360	COG0346	lactoylglutathione lyase activity
HEP74_RS04365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP74_RS04370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP74_RS04380	COG4206	TonB-dependent receptor
HEP74_RS04390	COG2010	Cytochrome c
HEP74_RS04400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP74_RS04405	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HEP74_RS04410	COG2909	trisaccharide binding
HEP74_RS04415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP74_RS04430	COG1773	rubredoxin
HEP74_RS04455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP74_RS04485	COG3079	Belongs to the UPF0149 family
HEP74_RS04490	COG0006	proline dipeptidase activity
HEP74_RS04495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_RS04510	COG5002	protein histidine kinase activity
HEP74_RS04515	COG3038	cytochrome b561
HEP74_RS04520	COG1309	transcriptional regulator
HEP74_RS04525	COG0006	proline dipeptidase activity
HEP74_RS04540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP74_RS04545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP74_RS04550	COG0346	lactoylglutathione lyase activity
HEP74_RS04555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP74_RS04560	COG1561	YicC-like family, N-terminal region
HEP74_RS04565	COG0194	GDP metabolic process
HEP74_RS04570	COG1758	RNA polymerase activity
HEP74_RS04575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP74_RS04585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP74_RS04595	COG0254	rRNA binding
HEP74_RS04600	COG0372	Belongs to the citrate synthase family
HEP74_RS04615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP74_RS04655	COG0714	Associated with various cellular activities
HEP74_RS04690	COG1301	dicarboxylic acid transport
HEP74_RS04695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP74_RS04720	COG0739	heme binding
HEP74_RS04725	COG1376	ErfK ybiS ycfS ynhG family protein
HEP74_RS04765	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HEP74_RS04770	COG4149	molybdate abc transporter
HEP74_RS04775	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP74_RS04785	COG0640	Transcriptional regulator
HEP74_RS04810	COG3591	Belongs to the peptidase S1B family
HEP74_RS04840	COG3047	cAMP biosynthetic process
HEP74_RS04845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP74_RS04860	COG4221	oxidoreductase activity
HEP74_RS04865	COG4221	oxidoreductase activity
HEP74_RS04875	COG3321	synthase
HEP74_RS04875	COG0604	alcohol dehydrogenase
HEP74_RS04880	COG0840	transmembrane signaling receptor activity
HEP74_RS04905	COG0469	pyruvate kinase activity
HEP74_RS04910	COG3588	fructose-bisphosphate aldolase
HEP74_RS04920	COG2205	protein histidine kinase activity
HEP74_RS04935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP74_RS04980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP74_RS05000	COG2072	flavoprotein involved in K transport
HEP74_RS05005	COG2351	hydroxyisourate hydrolase activity
HEP74_RS05015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP74_RS05035	COG1648	precorrin-2 dehydrogenase activity
HEP74_RS05035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP74_RS05050	COG0784	Response regulator, receiver
HEP74_RS05050	COG2198	Histidine kinase
HEP74_RS05050	COG2205	protein histidine kinase activity
HEP74_RS05055	COG0431	NADPH-dependent FMN reductase
HEP74_RS05060	COG1393	Belongs to the ArsC family
HEP74_RS05085	COG0175	sulfate reduction
HEP74_RS05090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP74_RS05095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_RS05105	COG0529	Catalyzes the synthesis of activated sulfate
HEP74_RS05105	COG2895	sulfate adenylyltransferase (ATP) activity
HEP74_RS05115	COG0438	transferase activity, transferring glycosyl groups
HEP74_RS05135	COG1115	amino acid carrier protein
HEP74_RS05145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP74_RS05170	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP74_RS05185	COG0471	metal ion transport
HEP74_RS05185	COG3273	potassium ion transport
HEP74_RS05195	COG2022	thiamine diphosphate biosynthetic process
HEP74_RS05220	COG3511	phospholipase C
HEP74_RS05230	COG0189	ligase activity
HEP74_RS05240	COG0745	RESPONSE REGULATOR receiver
HEP74_RS05255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEP74_RS05300	COG4993	Dehydrogenase
HEP74_RS05305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP74_RS05305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP74_RS05315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP74_RS05325	COG1174	glycine betaine transport
HEP74_RS05330	COG1125	glycine betaine transport
HEP74_RS05340	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP74_RS05345	COG0564	pseudouridine synthase activity
HEP74_RS05365	COG0840	transmembrane signaling receptor activity
HEP74_RS05370	COG4993	Dehydrogenase
HEP74_RS05380	COG3387	PFAM Glycoside hydrolase 15-related
HEP74_RS05400	COG4771	TonB-dependent receptor
HEP74_RS05410	COG0454	-acetyltransferase
HEP74_RS05435	COG0542	response to heat
HEP74_RS05460	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS05465	COG1733	regulation of RNA biosynthetic process
HEP74_RS05475	COG2223	nitrite transmembrane transporter activity
HEP74_RS05485	COG0019	diaminopimelate decarboxylase activity
HEP74_RS05490	COG4264	IucA IucC family
HEP74_RS05495	COG2814	Major facilitator Superfamily
HEP74_RS05500	COG4264	IucA IucC family
HEP74_RS05510	COG4772	TonB-dependent receptor
HEP74_RS05520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP74_RS05520	COG4651	solute:proton antiporter activity
HEP74_RS05550	COG0488	(ABC) transporter
HEP74_RS05580	COG0657	acetylesterase activity
HEP74_RS05580	COG2755	lipolytic protein G-D-S-L family
HEP74_RS05590	COG4774	siderophore transport
HEP74_RS05630	COG0217	transcriptional regulatory protein
HEP74_RS05640	COG0632	four-way junction helicase activity
HEP74_RS05655	COG0824	Thioesterase
HEP74_RS05665	COG0848	biopolymer transport protein
HEP74_RS05675	COG0823	Involved in the tonB-independent uptake of proteins
HEP74_RS05680	COG2885	chlorophyll binding
HEP74_RS05690	COG0602	queuosine metabolic process
HEP74_RS05695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEP74_RS05730	COG0514	ATP-dependent DNA helicase (RecQ)
HEP74_RS05740	COG0783	Belongs to the Dps family
HEP74_RS05745	COG1643	Atp-dependent helicase
HEP74_RS05785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP74_RS05795	COG1216	Glycosyl transferase, family 2
HEP74_RS05800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP74_RS05810	COG1199	ATP-dependent helicase activity
HEP74_RS05820	COG1397	ADP-ribosylglycohydrolase
HEP74_RS05835	COG0189	ligase activity
HEP74_RS05850	COG0835	chemotaxis
HEP74_RS05855	COG0840	transmembrane signaling receptor activity
HEP74_RS05860	COG0643	Histidine kinase
HEP74_RS05860	COG0784	Response regulator, receiver
HEP74_RS05860	COG2198	Histidine kinase
HEP74_RS05865	COG2201	protein-glutamate methylesterase activity
HEP74_RS05890	COG1446	asparaginase
HEP74_RS05970	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HEP74_RS05990	COG0583	DNA-binding transcription factor activity
HEP74_RS06020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP74_RS06075	COG3537	Alpha-1,2-mannosidase
HEP74_RS06085	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_RS06095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP74_RS06100	COG1388	LysM domain
HEP74_RS06100	COG3858	chitin binding
HEP74_RS06115	COG0837	glucose binding
HEP74_RS06125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEP74_RS06135	COG0494	nUDIX hydrolase
HEP74_RS06145	COG3956	TIGRFAM MazG family protein
HEP74_RS06150	COG1742	UPF0060 membrane protein
HEP74_RS06160	COG0330	HflC and HflK could
HEP74_RS06200	COG0697	spore germination
HEP74_RS06225	COG1960	acyl-CoA dehydrogenase activity
HEP74_RS06250	COG0457	Tetratricopeptide repeat
HEP74_RS06265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEP74_RS06270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP74_RS06275	COG0463	Glycosyl transferase, family 2
HEP74_RS06280	COG0517	IMP dehydrogenase activity
HEP74_RS06285	COG2982	Protein involved in outer membrane biogenesis
HEP74_RS06290	COG1272	protein, Hemolysin III
HEP74_RS06295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEP74_RS06305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP74_RS06310	COG0626	cystathionine gamma-synthase activity
HEP74_RS06315	COG0460	homoserine dehydrogenase
HEP74_RS06315	COG0527	aspartate kinase activity
HEP74_RS06330	COG1760	l-serine dehydratase
HEP74_RS06345	COG3038	cytochrome b561
HEP74_RS06365	COG0477	Major facilitator Superfamily
HEP74_RS06370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP74_RS06385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP74_RS06450	COG3706	GGDEF domain
HEP74_RS06490	COG0519	Catalyzes the synthesis of GMP from XMP
HEP74_RS06505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP74_RS06540	COG1113	amino acid transport
HEP74_RS06560	COG2239	Acts as a magnesium transporter
HEP74_RS06565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP74_RS06570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP74_RS06580	COG1660	Displays ATPase and GTPase activities
HEP74_RS06590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP74_RS06605	COG1137	ATPase activity
HEP74_RS06620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEP74_RS06655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEP74_RS06680	COG0628	permease
HEP74_RS06690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP74_RS06695	COG3178	'Phosphotransferase
HEP74_RS06710	COG1555	photosystem II stabilization
HEP74_RS06735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_RS06740	COG1477	protein flavinylation
HEP74_RS06765	COG4774	siderophore transport
HEP74_RS06770	COG2146	nitrite reductase [NAD(P)H] activity
HEP74_RS06780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP74_RS06785	COG0719	Fe-S assembly protein
HEP74_RS06790	COG0396	ATPase activity
HEP74_RS06795	COG0719	Fe-S assembly protein
HEP74_RS06810	COG0693	protein deglycase activity
HEP74_RS06825	COG0739	heme binding
HEP74_RS06840	COG1764	response to oxidative stress
HEP74_RS06850	COG0384	phenazine biosynthesis protein PhzF
HEP74_RS06855	COG0527	aspartate kinase activity
HEP74_RS06880	COG0142	geranyltranstransferase activity
HEP74_RS06885	COG0629	single-stranded DNA binding
HEP74_RS06895	COG1858	cytochrome C peroxidase
HEP74_RS06930	COG4615	Cyclic peptide transporter
HEP74_RS06955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS06960	COG1136	(ABC) transporter
HEP74_RS06960	COG0577	efflux transmembrane transporter activity
HEP74_RS06965	COG1136	(ABC) transporter
HEP74_RS06965	COG0577	efflux transmembrane transporter activity
HEP74_RS06980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP74_RS07010	COG2010	Cytochrome c
HEP74_RS07020	COG0673	inositol 2-dehydrogenase activity
HEP74_RS07025	COG2211	Major facilitator Superfamily
HEP74_RS07035	COG1609	Transcriptional regulator
HEP74_RS07050	COG3104	oligopeptide transport
HEP74_RS07055	COG1297	OPT oligopeptide transporter protein
HEP74_RS07060	COG0823	Involved in the tonB-independent uptake of proteins
HEP74_RS07060	COG1506	peptidase
HEP74_RS07080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP74_RS07085	COG2879	small protein
HEP74_RS07090	COG1966	Carbon starvation protein
HEP74_RS07095	COG1741	Belongs to the pirin family
HEP74_RS07105	COG1741	Belongs to the pirin family
HEP74_RS07135	COG2211	Major facilitator Superfamily
HEP74_RS07145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP74_RS07160	COG5001	Diguanylate cyclase
HEP74_RS07160	COG4251	negative regulation of phosphorylation
HEP74_RS07160	COG3706	GGDEF domain
HEP74_RS07160	COG2203	Gaf domain
HEP74_RS07165	COG0835	chemotaxis
HEP74_RS07170	COG0840	transmembrane signaling receptor activity
HEP74_RS07180	COG0840	transmembrane signaling receptor activity
HEP74_RS07185	COG2198	Histidine kinase
HEP74_RS07185	COG0643	Histidine kinase
HEP74_RS07195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEP74_RS07210	COG3878	Protein conserved in bacteria
HEP74_RS07215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEP74_RS07225	COG0642	Histidine kinase
HEP74_RS07230	COG3111	PFAM Bacterial OB fold (BOF) protein
HEP74_RS07235	COG0745	RESPONSE REGULATOR receiver
HEP74_RS07240	COG2205	protein histidine kinase activity
HEP74_RS07245	COG4452	Inner membrane protein CreD
HEP74_RS07270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP74_RS07275	COG0735	belongs to the Fur family
HEP74_RS07310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_RS07320	COG1309	transcriptional regulator
HEP74_RS07335	COG3214	Protein conserved in bacteria
HEP74_RS07355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP74_RS07360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP74_RS07365	COG2080	2 iron, 2 sulfur cluster binding
HEP74_RS07400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP74_RS07465	COG1187	pseudouridine synthase activity
HEP74_RS07490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP74_RS07495	COG3795	YCII-related domain
HEP74_RS07515	COG4941	Belongs to the sigma-70 factor family
HEP74_RS07540	COG1132	(ABC) transporter
HEP74_RS07575	COG0583	DNA-binding transcription factor activity
HEP74_RS07620	COG1981	membrane
HEP74_RS07630	COG0825	malonyl-CoA metabolic process
HEP74_RS07650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP74_RS07670	COG0750	zinc metalloprotease
HEP74_RS07675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP74_RS07680	COG0575	Belongs to the CDS family
HEP74_RS07685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP74_RS07695	COG0528	UMP kinase activity
HEP74_RS07705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP74_RS07745	COG0024	Methionine aminopeptidase
HEP74_RS07760	COG1393	Belongs to the ArsC family
HEP74_RS07765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP74_RS07770	COG0367	asparagine synthase
HEP74_RS07825	COG1566	PFAM secretion protein HlyD family protein
HEP74_RS07830	COG2814	Major facilitator Superfamily
HEP74_RS07870	COG0557	exoribonuclease II activity
HEP74_RS07880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP74_RS07895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP74_RS07915	COG0704	Plays a role in the regulation of phosphate uptake
HEP74_RS07925	COG0581	inorganic phosphate transmembrane transporter activity
HEP74_RS07940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP74_RS07960	COG0659	secondary active sulfate transmembrane transporter activity
HEP74_RS07965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEP74_RS07975	COG1024	Enoyl-CoA hydratase
HEP74_RS08020	COG0488	(ABC) transporter
HEP74_RS08035	COG5002	protein histidine kinase activity
HEP74_RS08035	COG2205	protein histidine kinase activity
HEP74_RS08035	COG0784	Response regulator, receiver
HEP74_RS08040	COG2733	membrane
HEP74_RS08080	COG0686	Belongs to the AlaDH PNT family
HEP74_RS08085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP74_RS08090	COG1396	sequence-specific DNA binding
HEP74_RS08090	COG1917	Cupin 2, conserved barrel domain protein
HEP74_RS08095	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_RS08115	COG0243	molybdopterin cofactor binding
HEP74_RS08125	COG0477	Major facilitator Superfamily
HEP74_RS08135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_RS08140	COG0174	glutamine synthetase
HEP74_RS08145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP74_RS08150	COG0174	glutamine synthetase
HEP74_RS08160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP74_RS08165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP74_RS08185	COG3842	ATPase activity
HEP74_RS08190	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP74_RS08195	COG1177	transmembrane transport
HEP74_RS08200	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_RS08205	COG0598	Magnesium transport protein CorA
HEP74_RS08215	COG4535	Mg2 and Co2 transporter CorC
HEP74_RS08240	COG1702	phosphate starvation-inducible protein PhoH
HEP74_RS08265	COG0741	lytic transglycosylase activity
HEP74_RS08270	COG0723	plastoquinol--plastocyanin reductase activity
HEP74_RS08275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP74_RS08285	COG2857	Cytochrome c1
HEP74_RS08290	COG0625	glutathione transferase activity
HEP74_RS08295	COG2969	positive regulation of protein catabolic process
HEP74_RS08335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP74_RS08340	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS08345	COG2095	MarC family integral membrane protein
HEP74_RS08360	COG1611	Belongs to the LOG family
HEP74_RS08365	COG3275	phosphorelay sensor kinase activity
HEP74_RS08410	COG0556	nucleotide-excision repair
HEP74_RS08445	COG2948	multi-organism process
HEP74_RS08465	COG3702	type iv secretory pathway
HEP74_RS08495	COG0366	Alpha amylase catalytic
HEP74_RS08505	COG1082	Xylose isomerase domain protein TIM barrel
HEP74_RS08550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP74_RS08560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP74_RS08565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP74_RS08570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP74_RS08570	COG0072	phenylalanine-tRNA ligase activity
HEP74_RS08615	COG0438	transferase activity, transferring glycosyl groups
HEP74_RS08620	COG0438	transferase activity, transferring glycosyl groups
HEP74_RS08630	COG0438	transferase activity, transferring glycosyl groups
HEP74_RS08655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP74_RS08665	COG1960	acyl-CoA dehydrogenase activity
HEP74_RS08685	COG1846	Transcriptional regulator
HEP74_RS08720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEP74_RS08725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP74_RS08725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEP74_RS08730	COG0802	atpase or kinase
HEP74_RS08735	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP74_RS08740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP74_RS08760	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS08780	COG2081	HI0933 family
HEP74_RS08785	COG4681	YaeQ
HEP74_RS08790	COG0564	pseudouridine synthase activity
HEP74_RS08800	COG0625	glutathione transferase activity
HEP74_RS08805	COG0657	acetylesterase activity
HEP74_RS08840	COG0513	Belongs to the DEAD box helicase family
HEP74_RS08855	COG0488	(ABC) transporter
HEP74_RS08875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP74_RS08880	COG2207	Transcriptional regulator
HEP74_RS08895	COG2197	response regulator
HEP74_RS08905	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_RS08940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP74_RS08945	COG1846	Transcriptional regulator
HEP74_RS08950	COG0339	signal peptide processing
HEP74_RS08955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP74_RS08960	COG0386	Belongs to the glutathione peroxidase family
HEP74_RS08990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP74_RS09035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEP74_RS09065	COG0084	hydrolase, TatD family'
HEP74_RS09080	COG1960	acyl-CoA dehydrogenase activity
HEP74_RS09095	COG0305	Participates in initiation and elongation during chromosome replication
HEP74_RS09110	COG2204	response regulator
HEP74_RS09120	COG0415	Belongs to the DNA photolyase family
HEP74_RS09135	COG0583	DNA-binding transcription factor activity
HEP74_RS09150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS09170	COG3706	GGDEF domain
HEP74_RS09175	COG0583	DNA-binding transcription factor activity
HEP74_RS09195	COG1404	Belongs to the peptidase S8 family
HEP74_RS09200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP74_RS09215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP74_RS09220	COG0735	belongs to the Fur family
HEP74_RS09225	COG0497	DNA recombination
HEP74_RS09230	COG1420	regulation of RNA biosynthetic process
HEP74_RS09235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP74_RS09240	COG0443	Heat shock 70 kDa protein
HEP74_RS09245	COG0484	heat shock protein binding
HEP74_RS09260	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HEP74_RS09265	COG1605	Chorismate mutase
HEP74_RS09265	COG0287	Prephenate dehydrogenase
HEP74_RS09275	COG1132	(ABC) transporter
HEP74_RS09330	COG2850	peptidyl-arginine hydroxylation
HEP74_RS09335	COG2885	chlorophyll binding
HEP74_RS09380	COG1131	(ABC) transporter
HEP74_RS09385	COG1725	Transcriptional regulator
HEP74_RS09395	COG0386	Belongs to the glutathione peroxidase family
HEP74_RS09410	COG2900	Belongs to the SlyX family
HEP74_RS09430	COG1410	methionine synthase
HEP74_RS09430	COG0646	methionine synthase
HEP74_RS09435	COG0646	methionine synthase
HEP74_RS09435	COG1410	methionine synthase
HEP74_RS09440	COG2226	methyltransferase
HEP74_RS09445	COG1960	acyl-CoA dehydrogenase activity
HEP74_RS09450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_RS09455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS09465	COG2902	Dehydrogenase
HEP74_RS09500	COG2925	Exonuclease
HEP74_RS09510	COG3844	kynureninase activity
HEP74_RS09515	COG1289	transmembrane transporter activity
HEP74_RS09525	COG0288	reversible hydration of carbon dioxide
HEP74_RS09570	COG2197	response regulator
HEP74_RS09600	COG0316	Belongs to the HesB IscA family
HEP74_RS09605	COG2977	Belongs to the P-Pant transferase superfamily
HEP74_RS09635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP74_RS09640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP74_RS09645	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HEP74_RS09670	COG4993	Dehydrogenase
HEP74_RS09715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP74_RS09745	COG4221	oxidoreductase activity
HEP74_RS09780	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HEP74_RS09785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP74_RS09790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP74_RS09795	COG0077	Prephenate dehydratase
HEP74_RS09795	COG1605	Chorismate mutase
HEP74_RS09815	COG0583	DNA-binding transcription factor activity
HEP74_RS09830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP74_RS09845	COG1530	ribonuclease E activity
HEP74_RS09855	COG3064	Membrane
HEP74_RS09860	COG0428	transporter
HEP74_RS09875	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEP74_RS09875	COG0316	Belongs to the HesB IscA family
HEP74_RS09895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS09915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP74_RS09920	COG2957	Belongs to the agmatine deiminase family
HEP74_RS09935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP74_RS09940	COG0539	negative regulation of cytoplasmic translation
HEP74_RS09945	COG0776	regulation of translation
HEP74_RS09955	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEP74_RS09970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP74_RS09975	COG0183	Belongs to the thiolase family
HEP74_RS09980	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP74_RS09980	COG1024	Enoyl-CoA hydratase
HEP74_RS09995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP74_RS10005	COG1426	Protein conserved in bacteria
HEP74_RS10015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP74_RS10025	COG0746	molybdenum cofactor guanylyltransferase activity
HEP74_RS10035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP74_RS10040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP74_RS10040	COG0475	glutathione-regulated potassium exporter activity
HEP74_RS10060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP74_RS10070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP74_RS10070	COG0519	Catalyzes the synthesis of GMP from XMP
HEP74_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS10105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_RS10115	COG1309	transcriptional regulator
HEP74_RS10120	COG1538	Outer membrane efflux protein
HEP74_RS10125	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP74_RS10130	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP74_RS10135	COG0784	Response regulator, receiver
HEP74_RS10135	COG4191	Histidine kinase
HEP74_RS10145	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEP74_RS10155	COG1914	H( )-stimulated, divalent metal cation uptake system
HEP74_RS10170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP74_RS10175	COG0668	transmembrane transport
HEP74_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS10205	COG1183	phosphatidylcholine synthase activity
HEP74_RS10215	COG3243	poly(R)-hydroxyalkanoic acid synthase
HEP74_RS10235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEP74_RS10235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_RS10245	COG0784	Response regulator, receiver
HEP74_RS10245	COG4191	Histidine kinase
HEP74_RS10250	COG2183	response to ionizing radiation
HEP74_RS10255	COG0784	Response regulator, receiver
HEP74_RS10255	COG2205	protein histidine kinase activity
HEP74_RS10300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS10320	COG5000	phosphorelay sensor kinase activity
HEP74_RS10320	COG5002	protein histidine kinase activity
HEP74_RS10330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS10375	COG2197	response regulator
HEP74_RS10380	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS10390	COG1335	isochorismatase
HEP74_RS10395	COG4585	Histidine kinase
HEP74_RS10405	COG0714	Associated with various cellular activities
HEP74_RS10415	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP74_RS10435	COG0577	efflux transmembrane transporter activity
HEP74_RS10435	COG1136	(ABC) transporter
HEP74_RS10490	COG1132	(ABC) transporter
HEP74_RS10510	COG0438	transferase activity, transferring glycosyl groups
HEP74_RS10515	COG0297	glycogen (starch) synthase activity
HEP74_RS10535	COG2226	methyltransferase
HEP74_RS10555	COG2244	polysaccharide biosynthetic process
HEP74_RS10585	COG3038	cytochrome b561
HEP74_RS10605	COG1595	DNA-templated transcription, initiation
HEP74_RS10680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP74_RS10685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEP74_RS10690	COG1230	cation diffusion facilitator family transporter
HEP74_RS10705	COG1674	ftsk spoiiie
HEP74_RS10710	COG0492	ferredoxin-NADP+ reductase activity
HEP74_RS10730	COG0542	response to heat
HEP74_RS10750	COG0482	sulfurtransferase activity
HEP74_RS10755	COG2915	High frequency lysogenization protein hflD homolog
HEP74_RS10770	COG1116	anion transmembrane transporter activity
HEP74_RS10820	COG0784	Response regulator, receiver
HEP74_RS10820	COG0835	chemotaxis
HEP74_RS10830	COG1558	bacterial-type flagellum-dependent cell motility
HEP74_RS10835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HEP74_RS10840	COG1749	Flagellar hook protein flgE
HEP74_RS10855	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HEP74_RS10870	COG4786	Flagellar basal body rod
HEP74_RS10870	COG1256	bacterial-type flagellum assembly
HEP74_RS10875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HEP74_RS10885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HEP74_RS10905	COG2197	response regulator
HEP74_RS10915	COG2201	protein-glutamate methylesterase activity
HEP74_RS10935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_RS10940	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS10985	COG1677	Flagellar hook-basal body complex protein FliE
HEP74_RS11035	COG3190	flagellar
HEP74_RS11045	COG1987	bacterial-type flagellum assembly
HEP74_RS11050	COG1684	flagellar biosynthetic protein fliR
HEP74_RS11100	COG2198	Histidine kinase
HEP74_RS11100	COG0643	Histidine kinase
HEP74_RS11100	COG0784	Response regulator, receiver
HEP74_RS11105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HEP74_RS11115	COG1192	Involved in chromosome partitioning
HEP74_RS11130	COG0745	RESPONSE REGULATOR receiver
HEP74_RS11140	COG0840	transmembrane signaling receptor activity
HEP74_RS11145	COG0840	transmembrane signaling receptor activity
HEP74_RS11150	COG0840	transmembrane signaling receptor activity
HEP74_RS11160	COG0840	transmembrane signaling receptor activity
HEP74_RS11165	COG0840	transmembrane signaling receptor activity
HEP74_RS11170	COG0840	transmembrane signaling receptor activity
HEP74_RS11175	COG0840	transmembrane signaling receptor activity
HEP74_RS11185	COG0840	transmembrane signaling receptor activity
HEP74_RS11190	COG0840	transmembrane signaling receptor activity
HEP74_RS11200	COG0835	chemotaxis
HEP74_RS11210	COG0840	transmembrane signaling receptor activity
HEP74_RS11225	COG0840	transmembrane signaling receptor activity
HEP74_RS11280	COG0318	PFAM AMP-dependent synthetase and ligase
HEP74_RS11285	COG1024	Enoyl-CoA hydratase
HEP74_RS11290	COG2198	Histidine kinase
HEP74_RS11290	COG2205	protein histidine kinase activity
HEP74_RS11290	COG0784	Response regulator, receiver
HEP74_RS11310	COG3279	Response regulator of the LytR AlgR family
HEP74_RS11315	COG4676	Protein conserved in bacteria
HEP74_RS11330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP74_RS11335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP74_RS11345	COG0505	Belongs to the CarA family
HEP74_RS11355	COG2258	MOSC domain
HEP74_RS11360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP74_RS11395	COG1024	Enoyl-CoA hydratase
HEP74_RS11415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP74_RS11435	COG0277	FAD linked oxidase domain protein
HEP74_RS11440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP74_RS11455	COG0531	amino acid
HEP74_RS11460	COG0531	amino acid
HEP74_RS11465	COG0235	Class ii aldolase
HEP74_RS11470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP74_RS11475	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP74_RS11490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP74_RS11490	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP74_RS11505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP74_RS11520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP74_RS11525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP74_RS11535	COG0124	histidyl-tRNA synthetase
HEP74_RS11540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP74_RS11550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP74_RS11560	COG0460	homoserine dehydrogenase
HEP74_RS11560	COG0527	aspartate kinase activity
HEP74_RS11580	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_RS11605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP74_RS11620	COG1794	racemase activity, acting on amino acids and derivatives
HEP74_RS11625	COG0671	phosphoesterase, PA-phosphatase related
HEP74_RS11640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HEP74_RS11660	COG0166	Belongs to the GPI family
HEP74_RS11675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP74_RS11685	COG0617	tRNA 3'-terminal CCA addition
HEP74_RS11705	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP74_RS11710	COG0477	Major facilitator Superfamily
HEP74_RS11715	COG2115	Belongs to the xylose isomerase family
HEP74_RS11720	COG1070	Carbohydrate kinase
HEP74_RS11730	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP74_RS11765	COG0800	Aldolase
HEP74_RS11780	COG3734	2-keto-3-deoxy-galactonokinase
HEP74_RS11785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEP74_RS11795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP74_RS11805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEP74_RS11810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP74_RS11825	COG0351	phosphomethylpyrimidine kinase
HEP74_RS11825	COG0352	thiamine-phosphate diphosphorylase activity
HEP74_RS11850	COG0583	DNA-binding transcription factor activity
HEP74_RS11855	COG1741	Belongs to the pirin family
HEP74_RS11870	COG0194	GDP metabolic process
HEP74_RS11885	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEP74_RS11890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP74_RS11895	COG2137	regulation of response to DNA damage stimulus
HEP74_RS11900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP74_RS11905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP74_RS11910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP74_RS11915	COG1546	Belongs to the CinA family
HEP74_RS11925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP74_RS11940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP74_RS11945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP74_RS11955	COG1534	Rna-binding protein
HEP74_RS11975	COG1238	metal cluster binding
HEP74_RS11985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEP74_RS12000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP74_RS12005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP74_RS12010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HEP74_RS12030	COG0504	CTP synthase activity
HEP74_RS12050	COG0306	phosphate transporter
HEP74_RS12060	COG1253	flavin adenine dinucleotide binding
HEP74_RS12075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP74_RS12110	COG0069	glutamate synthase activity
HEP74_RS12115	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP74_RS12130	COG1609	Transcriptional regulator
HEP74_RS12135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP74_RS12135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP74_RS12140	COG1105	Belongs to the carbohydrate kinase PfkB family
HEP74_RS12145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP74_RS12145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP74_RS12180	COG0577	efflux transmembrane transporter activity
HEP74_RS12180	COG1136	(ABC) transporter
HEP74_RS12225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP74_RS12235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP74_RS12240	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HEP74_RS12250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP74_RS12260	COG0348	domain, Protein
HEP74_RS12310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP74_RS12315	COG0322	excinuclease ABC activity
HEP74_RS12325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP74_RS12340	COG1663	tetraacyldisaccharide 4'-kinase activity
HEP74_RS12345	COG1132	(ABC) transporter
HEP74_RS12355	COG0811	peptide transport
HEP74_RS12360	COG0658	competence protein
HEP74_RS12360	COG2333	competence protein COMEC
HEP74_RS12375	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP74_RS12400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEP74_RS12415	COG0354	folic acid binding
HEP74_RS12420	COG3842	ATPase activity
HEP74_RS12425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP74_RS12440	COG0129	dihydroxy-acid dehydratase activity
HEP74_RS12445	COG0800	Aldolase
HEP74_RS12455	COG0395	ABC-type sugar transport system, permease component
HEP74_RS12495	COG2350	Protein conserved in bacteria
HEP74_RS12500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEP74_RS12505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP74_RS12510	COG1187	pseudouridine synthase activity
HEP74_RS12535	COG0436	Aminotransferase
HEP74_RS12540	COG4133	protoheme IX ABC transporter activity
HEP74_RS12560	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HEP74_RS12590	COG1278	Cold shock
HEP74_RS12595	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEP74_RS12600	COG4988	ABC transporter
HEP74_RS12610	COG1294	oxidase, subunit
HEP74_RS12640	COG1064	alcohol dehydrogenase
HEP74_RS12660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP74_RS12680	COG0165	Argininosuccinate lyase
HEP74_RS12685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP74_RS12695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP74_RS12700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP74_RS12705	COG0137	argininosuccinate synthase activity
HEP74_RS12710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP74_RS12725	COG2166	iron-sulfur cluster assembly
HEP74_RS12795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP74_RS12820	COG4303	Ethanolamine ammonia lyase large subunit
HEP74_RS12825	COG4302	ethanolamine ammonia-lyase activity
HEP74_RS12830	COG4677	pectinesterase activity
HEP74_RS12850	COG0402	S-adenosylhomocysteine deaminase activity
HEP74_RS12855	COG3548	integral membrane protein
HEP74_RS12865	COG1509	lysine 2,3-aminomutase activity
HEP74_RS12905	COG1862	Preprotein translocase
HEP74_RS12920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP74_RS12930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP74_RS12940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP74_RS12960	COG3291	Pkd domain containing protein
HEP74_RS12965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP74_RS12975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEP74_RS12990	COG0742	ribosomal rna small subunit methyltransferase
HEP74_RS13005	COG3209	COG3209 Rhs family protein
HEP74_RS13025	COG3345	alpha-galactosidase
HEP74_RS13035	COG4771	TonB-dependent receptor
HEP74_RS13045	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP74_RS13080	COG0531	amino acid
HEP74_RS13095	COG0006	proline dipeptidase activity
HEP74_RS13105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP74_RS13120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_RS13125	COG3938	Belongs to the proline racemase family
HEP74_RS13135	COG0552	protein localization to endoplasmic reticulum
HEP74_RS13140	COG1194	a g-specific adenine glycosylase
HEP74_RS13155	COG2304	oxidoreductase activity
HEP74_RS13190	COG0835	chemotaxis
HEP74_RS13195	COG0840	transmembrane signaling receptor activity
HEP74_RS13200	COG1201	RNA secondary structure unwinding
HEP74_RS13215	COG3300	MHYT domain
HEP74_RS13215	COG5001	Diguanylate cyclase
HEP74_RS13220	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP74_RS13230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEP74_RS13245	COG0195	Participates in both transcription termination and antitermination
HEP74_RS13260	COG1007	ATP synthesis coupled electron transport
HEP74_RS13295	COG1034	ATP synthesis coupled electron transport
HEP74_RS13300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP74_RS13305	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HEP74_RS13310	COG0649	NAD binding
HEP74_RS13315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP74_RS13325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP74_RS13340	COG0149	triose-phosphate isomerase activity
HEP74_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS13360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP74_RS13410	COG0101	tRNA pseudouridine synthase activity
HEP74_RS13420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEP74_RS13435	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP74_RS13445	COG0688	phosphatidylethanolamine metabolic process
HEP74_RS13450	COG0741	lytic transglycosylase activity
HEP74_RS13455	COG0433	COG0433 Predicted ATPase
HEP74_RS13460	COG0494	nUDIX hydrolase
HEP74_RS13475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP74_RS13505	COG0717	Belongs to the dCTP deaminase family
HEP74_RS13510	COG0489	protein tyrosine kinase activity
HEP74_RS13515	COG4771	TonB-dependent receptor
HEP74_RS13520	COG0457	Tetratricopeptide repeat
HEP74_RS13530	COG3590	peptidase
HEP74_RS13540	COG0705	Rhomboid family
HEP74_RS13565	COG2311	Membrane
HEP74_RS13570	COG1047	Peptidyl-prolyl cis-trans
HEP74_RS13575	COG0791	NLP P60 protein
HEP74_RS13580	COG0791	NLP P60 protein
HEP74_RS13585	COG1607	acyl-coa hydrolase
HEP74_RS13590	COG4106	trans-aconitate 2-methyltransferase activity
HEP74_RS13595	COG1301	dicarboxylic acid transport
HEP74_RS13600	COG1785	Belongs to the alkaline phosphatase family
HEP74_RS13610	COG0037	tRNA processing
HEP74_RS13615	COG1722	exodeoxyribonuclease VII activity
HEP74_RS13620	COG0142	geranyltranstransferase activity
HEP74_RS13630	COG4104	PAAR repeat-containing protein
HEP74_RS13665	COG0312	modulator of DNA gyrase
HEP74_RS13675	COG0312	modulator of DNA gyrase
HEP74_RS13695	COG2968	Membrane
HEP74_RS13710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEP74_RS13725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP74_RS13740	COG0495	leucyl-tRNA aminoacylation
HEP74_RS13750	COG3118	belongs to the thioredoxin family
HEP74_RS13770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEP74_RS13780	COG2040	homocysteine
HEP74_RS13790	COG0346	lactoylglutathione lyase activity
HEP74_RS13795	COG1131	(ABC) transporter
HEP74_RS13810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP74_RS13810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP74_RS13820	COG2878	Part of a membrane complex involved in electron transport
HEP74_RS13835	COG1595	DNA-templated transcription, initiation
HEP74_RS13860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP74_RS13880	COG0251	oxidation-reduction process
HEP74_RS13890	COG0392	lysyltransferase activity
HEP74_RS13890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP74_RS13925	COG2814	Major facilitator Superfamily
HEP74_RS13930	COG1902	pentaerythritol trinitrate reductase activity
HEP74_RS13940	COG0583	DNA-binding transcription factor activity
HEP74_RS13955	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP74_RS13965	COG1047	Peptidyl-prolyl cis-trans
HEP74_RS13970	COG1077	Cell shape determining protein MreB Mrl
HEP74_RS14005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEP74_RS14015	COG1451	nucleotide metabolic process
HEP74_RS14035	COG2205	protein histidine kinase activity
HEP74_RS14045	COG2186	Transcriptional regulator
HEP74_RS14050	COG3250	beta-galactosidase activity
HEP74_RS14110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP74_RS14110	COG1703	isobutyryl-CoA mutase activity
HEP74_RS14110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP74_RS14145	COG0443	Heat shock 70 kDa protein
HEP74_RS14175	COG1960	acyl-CoA dehydrogenase activity
HEP74_RS14180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP74_RS14180	COG1793	dna ligase
HEP74_RS14185	COG1793	dna ligase
HEP74_RS14185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP74_RS14190	COG1201	RNA secondary structure unwinding
HEP74_RS14200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP74_RS14205	COG1278	Cold shock
HEP74_RS14210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP74_RS14215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEP74_RS14220	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_RS14230	COG2954	triphosphatase activity
HEP74_RS14245	COG1381	Involved in DNA repair and RecF pathway recombination
HEP74_RS14250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP74_RS14265	COG0681	Belongs to the peptidase S26 family
HEP74_RS14270	COG0481	GTPase activity
HEP74_RS14275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP74_RS14290	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP74_RS14290	COG1024	Enoyl-CoA hydratase
HEP74_RS14300	COG2855	membrane
HEP74_RS14315	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HEP74_RS14320	COG3250	beta-galactosidase activity
HEP74_RS14325	COG3540	Alkaline phosphatase
HEP74_RS14350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEP74_RS14370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HEP74_RS14380	COG0534	Mate efflux family protein
HEP74_RS14385	COG0335	large ribosomal subunit rRNA binding
HEP74_RS14395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP74_RS14400	COG0228	four-way junction DNA binding
HEP74_RS14410	COG2070	2-Nitropropane dioxygenase
HEP74_RS14415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEP74_RS14440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP74_RS14460	COG0475	glutathione-regulated potassium exporter activity
HEP74_RS14480	COG0625	glutathione transferase activity
HEP74_RS14485	COG1082	Xylose isomerase domain protein TIM barrel
HEP74_RS14495	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP74_RS14500	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP74_RS14505	COG1129	ABC transporter
HEP74_RS14510	COG1879	ABC-type sugar transport system periplasmic component
HEP74_RS14515	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS14535	COG0129	dihydroxy-acid dehydratase activity
HEP74_RS14570	COG3152	Membrane
HEP74_RS14590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEP74_RS14595	COG1845	cytochrome c oxidase, subunit III
HEP74_RS14600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP74_RS14610	COG2964	Protein conserved in bacteria
HEP74_RS14625	COG4771	TonB-dependent receptor
HEP74_RS14650	COG0251	oxidation-reduction process
HEP74_RS14675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP74_RS14690	COG0196	riboflavin kinase activity
HEP74_RS14695	COG0728	peptidoglycan biosynthetic process
HEP74_RS14705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP74_RS14710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP74_RS14715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP74_RS14720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP74_RS14725	COG0824	Thioesterase
HEP74_RS14735	COG1024	Enoyl-CoA hydratase
HEP74_RS14735	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP74_RS14740	COG1946	Acyl-CoA thioesterase
HEP74_RS14755	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HEP74_RS14770	COG0840	transmembrane signaling receptor activity
HEP74_RS14790	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HEP74_RS14810	COG1073	alpha beta
HEP74_RS14845	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEP74_RS14865	COG4585	Histidine kinase
HEP74_RS14875	COG0850	regulation of cytokinetic process
HEP74_RS14880	COG2894	cell division
HEP74_RS14885	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEP74_RS14895	COG2205	protein histidine kinase activity
HEP74_RS14900	COG0745	RESPONSE REGULATOR receiver
HEP74_RS14910	COG2194	sulfuric ester hydrolase activity
HEP74_RS14935	COG2814	Major facilitator Superfamily
HEP74_RS14940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP74_RS14940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP74_RS14950	COG3706	GGDEF domain
HEP74_RS14950	COG4251	negative regulation of phosphorylation
HEP74_RS14950	COG5001	Diguanylate cyclase
HEP74_RS14950	COG2203	Gaf domain
HEP74_RS14955	COG0753	catalase activity
HEP74_RS14980	COG1063	alcohol dehydrogenase
HEP74_RS14990	COG3459	Glycosyltransferase 36 associated
HEP74_RS14995	COG2186	Transcriptional regulator
HEP74_RS15015	COG2271	Major facilitator Superfamily
HEP74_RS15020	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS15060	COG1064	alcohol dehydrogenase
HEP74_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS15095	COG0492	ferredoxin-NADP+ reductase activity
HEP74_RS15125	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS15130	COG3387	PFAM Glycoside hydrolase 15-related
HEP74_RS15140	COG3275	phosphorelay sensor kinase activity
HEP74_RS15190	COG0732	type I restriction modification DNA specificity domain
HEP74_RS15240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP74_RS15250	COG0330	HflC and HflK could
HEP74_RS15255	COG0330	HflC and HflK could
HEP74_RS15260	COG0604	alcohol dehydrogenase
HEP74_RS15280	COG0678	peroxiredoxin activity
HEP74_RS15300	COG4953	penicillin-binding protein 1C
HEP74_RS15305	COG1349	DNA-binding transcription factor activity
HEP74_RS15315	COG2223	nitrite transmembrane transporter activity
HEP74_RS15345	COG0577	efflux transmembrane transporter activity
HEP74_RS15345	COG1136	(ABC) transporter
HEP74_RS15365	COG2373	Large extracellular alpha-helical protein
HEP74_RS15415	COG0372	Belongs to the citrate synthase family
HEP74_RS15430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP74_RS15445	COG0587	DNA-directed DNA polymerase activity
HEP74_RS15480	COG2161	toxin-antitoxin pair type II binding
HEP74_RS15485	COG4115	mRNA cleavage
HEP74_RS15505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP74_RS15510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP74_RS15515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP74_RS15525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP74_RS15530	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS15535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEP74_RS15540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_RS15550	COG1399	metal-binding, possibly nucleic acid-binding protein
HEP74_RS15575	COG0714	Associated with various cellular activities
HEP74_RS15595	COG0537	adenosine 5'-monophosphoramidase activity
HEP74_RS15625	COG0314	molybdopterin synthase activity
HEP74_RS15630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEP74_RS15635	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP74_RS15645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP74_RS15650	COG1234	tRNA 3'-trailer cleavage
HEP74_RS15660	COG0859	PFAM glycosyl transferase family 9
HEP74_RS15680	COG0631	protein serine/threonine phosphatase activity
HEP74_RS15685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP74_RS15700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP74_RS15705	COG3942	CHAP domain
HEP74_RS15705	COG1388	LysM domain
HEP74_RS15740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP74_RS15750	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP74_RS15795	COG0473	3-isopropylmalate dehydrogenase activity
HEP74_RS15810	COG4783	chaperone-mediated protein folding
HEP74_RS15825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP74_RS15830	COG0248	Ppx GppA phosphatase
HEP74_RS15835	COG0438	transferase activity, transferring glycosyl groups
HEP74_RS15845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP74_RS15855	COG3291	Pkd domain containing protein
HEP74_RS15860	COG2833	Protein of unknown function (DUF455)
HEP74_RS15880	COG0285	dihydrofolate synthase activity
HEP74_RS15885	COG0588	phosphoglycerate mutase activity
HEP74_RS15905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEP74_RS15910	COG4208	sulfate ABC transporter
HEP74_RS15915	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEP74_RS15920	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEP74_RS15945	COG2885	chlorophyll binding
HEP74_RS15950	COG0583	DNA-binding transcription factor activity
HEP74_RS15955	COG2814	Major facilitator Superfamily
HEP74_RS15965	COG0667	Aldo Keto reductase
HEP74_RS15975	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP74_RS15975	COG1902	pentaerythritol trinitrate reductase activity
HEP74_RS16015	COG0625	glutathione transferase activity
HEP74_RS16045	COG0039	L-malate dehydrogenase activity
HEP74_RS16055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP74_RS16060	COG1217	gtp-binding protein TYPA
HEP74_RS16070	COG0154	amidase activity
HEP74_RS16080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP74_RS16090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HEP74_RS16095	COG0203	ribosomal protein L17
HEP74_RS16105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP74_RS16120	COG0201	protein transport
HEP74_RS16130	COG1841	ribosomal large subunit assembly
HEP74_RS16160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP74_RS16165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP74_RS16175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP74_RS16180	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP74_RS16205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP74_RS16210	COG0089	rRNA binding
HEP74_RS16215	COG0088	Forms part of the polypeptide exit tunnel
HEP74_RS16225	COG0051	transcription antitermination factor activity, RNA binding
HEP74_RS16230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP74_RS16235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP74_RS16250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP74_RS16260	COG0222	ribosome binding
HEP74_RS16275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP74_RS16280	COG0250	Participates in transcription elongation, termination and antitermination
HEP74_RS16295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP74_RS16315	COG0012	GTP binding
HEP74_RS16320	COG0193	aminoacyl-tRNA hydrolase activity
HEP74_RS16330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP74_RS16340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP74_RS16355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP74_RS16360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP74_RS16375	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP74_RS16395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP74_RS16400	COG1295	ribonuclease BN
HEP74_RS16420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP74_RS16425	COG1404	Belongs to the peptidase S8 family
HEP74_RS16430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP74_RS16435	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP74_RS16490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP74_RS16490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP74_RS16520	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP74_RS16530	COG3634	alkyl hydroperoxide reductase activity
HEP74_RS16535	COG0583	DNA-binding transcription factor activity
HEP74_RS16545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP74_RS16550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP74_RS16570	COG2197	response regulator
HEP74_RS16595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP74_RS16610	COG0697	spore germination
HEP74_RS16655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP74_RS16660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP74_RS16670	COG2096	Adenosyltransferase
HEP74_RS16685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEP74_RS16690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEP74_RS16700	COG2967	ApaG domain
HEP74_RS16705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP74_RS16735	COG1704	LemA family
HEP74_RS16740	COG0861	Integral membrane protein TerC family
HEP74_RS16745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEP74_RS16760	COG2205	protein histidine kinase activity
HEP74_RS16780	COG0642	Histidine kinase
HEP74_RS16795	COG4181	ATPase activity
HEP74_RS16800	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEP74_RS16820	COG4771	TonB-dependent receptor
HEP74_RS16830	COG0667	Aldo Keto reductase
HEP74_RS16835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEP74_RS16855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP74_RS16905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP74_RS16910	COG4305	rare lipoprotein A
HEP74_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS16930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP74_RS16940	COG4191	Histidine kinase
HEP74_RS16945	COG0784	Response regulator, receiver
HEP74_RS16950	COG2205	protein histidine kinase activity
HEP74_RS16950	COG2202	Pas domain
HEP74_RS16960	COG2823	Periplasmic or secreted lipoprotein
HEP74_RS16965	COG0673	inositol 2-dehydrogenase activity
HEP74_RS16970	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP74_RS16980	COG1090	epimerase
HEP74_RS17010	COG1051	belongs to the nudix hydrolase family
HEP74_RS17010	COG1056	cytidyltransferase-related domain
HEP74_RS17040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP74_RS17045	COG0321	lipoyl(octanoyl) transferase activity
HEP74_RS17060	COG1686	Belongs to the peptidase S11 family
HEP74_RS17070	COG2951	lytic endotransglycosylase activity
HEP74_RS17075	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_RS17090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HEP74_RS17100	COG0772	Belongs to the SEDS family
HEP74_RS17105	COG0768	penicillin binding
HEP74_RS17115	COG1792	Involved in formation and maintenance of cell shape
HEP74_RS17120	COG1077	Cell shape determining protein MreB Mrl
HEP74_RS17125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP74_RS17130	COG3284	Transcriptional regulator
HEP74_RS17140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP74_RS17150	COG2010	Cytochrome c
HEP74_RS17175	COG0596	Alpha beta hydrolase
HEP74_RS17175	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP74_RS17180	COG0308	aminopeptidase N
HEP74_RS17185	COG2226	methyltransferase
HEP74_RS17220	COG0494	nUDIX hydrolase
HEP74_RS17235	COG0739	heme binding
HEP74_RS17245	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEP74_RS17250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP74_RS17260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEP74_RS17265	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP74_RS17275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP74_RS17290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEP74_RS17305	COG3116	cell division
HEP74_RS17310	COG0275	rRNA processing
HEP74_RS17315	COG2001	Belongs to the MraZ family
HEP74_RS17355	COG1988	membrane-bound metal-dependent
HEP74_RS17360	COG0277	FAD linked oxidase domain protein
HEP74_RS17375	COG0745	RESPONSE REGULATOR receiver
HEP74_RS17380	COG2205	protein histidine kinase activity
HEP74_RS17385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP74_RS17390	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP74_RS17395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP74_RS17415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEP74_RS17420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP74_RS17425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP74_RS17440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP74_RS17440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP74_RS17450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP74_RS17470	COG0477	Major facilitator Superfamily
HEP74_RS17475	COG0488	(ABC) transporter
HEP74_RS17480	COG0242	peptide deformylase activity
HEP74_RS17490	COG1960	acyl-CoA dehydrogenase activity
HEP74_RS17500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP74_RS17510	COG1696	Membrane protein involved in D-alanine export
HEP74_RS17530	COG1215	transferase activity, transferring glycosyl groups
HEP74_RS17540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEP74_RS17545	COG0457	Tetratricopeptide repeat
HEP74_RS17550	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEP74_RS17555	COG1215	transferase activity, transferring glycosyl groups
HEP74_RS17560	COG1215	transferase activity, transferring glycosyl groups
HEP74_RS17620	COG2188	Transcriptional regulator
HEP74_RS17635	COG1450	Type ii and iii secretion system protein
HEP74_RS17650	COG3166	PFAM Fimbrial assembly family protein
HEP74_RS17655	COG3156	type II secretion system protein K
HEP74_RS17660	COG4795	General secretion pathway protein
HEP74_RS17665	COG2165	general secretion pathway protein
HEP74_RS17670	COG4970	Tfp pilus assembly protein FimT
HEP74_RS17675	COG2165	general secretion pathway protein
HEP74_RS17685	COG1459	type II secretion system
HEP74_RS17690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP74_RS17695	COG1404	Belongs to the peptidase S8 family
HEP74_RS17700	COG5295	Hep Hag repeat protein
HEP74_RS17715	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP74_RS17715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP74_RS17720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP74_RS17725	COG4974	Belongs to the 'phage' integrase family
HEP74_RS17750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP74_RS17780	COG1183	phosphatidylcholine synthase activity
HEP74_RS17790	COG0442	prolyl-tRNA aminoacylation
HEP74_RS17805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP74_RS17810	COG1127	ABC transporter
HEP74_RS17815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP74_RS17815	COG3218	ABC-type transport auxiliary lipoprotein component
HEP74_RS17850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP74_RS17855	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HEP74_RS17855	COG0662	Cupin 2, conserved barrel domain protein
HEP74_RS17880	COG2086	electron transfer activity
HEP74_RS17895	COG0546	phosphoglycolate phosphatase activity
HEP74_RS17895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP74_RS17900	COG0277	FAD linked oxidase domain protein
HEP74_RS17905	COG0300	oxidoreductase activity
HEP74_RS17910	COG2226	methyltransferase
HEP74_RS17915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_RS17945	COG2226	methyltransferase
HEP74_RS17955	COG3754	Rhamnan synthesis protein F
HEP74_RS17960	COG0438	transferase activity, transferring glycosyl groups
HEP74_RS17960	COG1216	Glycosyl transferase, family 2
HEP74_RS17980	COG0626	cystathionine gamma-synthase activity
HEP74_RS18010	COG0625	glutathione transferase activity
HEP74_RS18020	COG0513	Belongs to the DEAD box helicase family
HEP74_RS18025	COG0720	synthase
HEP74_RS18035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP74_RS18040	COG1956	GAF domain-containing protein
HEP74_RS18050	COG4206	TonB-dependent receptor
HEP74_RS18055	COG0546	phosphoglycolate phosphatase activity
HEP74_RS18075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP74_RS18100	COG0339	signal peptide processing
HEP74_RS18105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP74_RS18115	COG2217	Heavy metal translocating P-type atpase
HEP74_RS18130	COG2132	Multicopper oxidase
HEP74_RS18155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP74_RS18165	COG1136	(ABC) transporter
HEP74_RS18170	COG0577	efflux transmembrane transporter activity
HEP74_RS18175	COG1136	(ABC) transporter
HEP74_RS18175	COG0577	efflux transmembrane transporter activity
HEP74_RS18180	COG0577	efflux transmembrane transporter activity
HEP74_RS18185	COG0577	efflux transmembrane transporter activity
HEP74_RS18195	COG0577	efflux transmembrane transporter activity
HEP74_RS18195	COG1136	(ABC) transporter
HEP74_RS18205	COG0577	efflux transmembrane transporter activity
HEP74_RS18205	COG1136	(ABC) transporter
HEP74_RS18220	COG4191	Histidine kinase
HEP74_RS18230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP74_RS18245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP74_RS18260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP74_RS18270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP74_RS18280	COG0356	it plays a direct role in the translocation of protons across the membrane
HEP74_RS18300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP74_RS18305	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP74_RS18340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP74_RS18345	COG0697	spore germination
HEP74_RS18350	COG1666	GTP binding
HEP74_RS18360	COG1187	pseudouridine synthase activity
HEP74_RS18385	COG2205	protein histidine kinase activity
HEP74_RS18385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP74_RS18410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_RS18475	COG0842	Transport permease protein
HEP74_RS18480	COG1131	(ABC) transporter
HEP74_RS18485	COG0025	NhaP-type Na H and K H
HEP74_RS18495	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEP74_RS18500	COG1573	uracil-dna glycosylase
HEP74_RS18510	COG3384	dioxygenase
HEP74_RS18530	COG0667	Aldo Keto reductase
HEP74_RS18535	COG0667	Aldo Keto reductase
HEP74_RS18550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_RS18555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_RS18585	COG5001	Diguanylate cyclase
HEP74_RS18620	COG3275	phosphorelay sensor kinase activity
HEP74_RS18645	COG0531	amino acid
HEP74_RS18665	COG5297	Belongs to the glycosyl hydrolase family 6
HEP74_RS18665	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP74_RS18670	COG0612	Peptidase, M16
HEP74_RS18695	COG0741	lytic transglycosylase activity
HEP74_RS18720	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP74_RS18725	COG2207	Transcriptional regulator
HEP74_RS18735	COG0598	Magnesium transport protein CorA
HEP74_RS18740	COG1113	amino acid transport
HEP74_RS18750	COG0697	spore germination
HEP74_RS18785	COG2409	Drug exporters of the RND superfamily
HEP74_RS18790	COG4178	(ABC) transporter
HEP74_RS18800	COG5520	Belongs to the glycosyl hydrolase 30 family
HEP74_RS18970	COG0584	glycerophosphoryl diester phosphodiesterase
HEP74_RS18995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP74_RS19025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEP74_RS19050	COG1595	DNA-templated transcription, initiation
HEP74_RS19055	COG0459	protein refolding
HEP74_RS19065	COG2356	endonuclease I
HEP74_RS19070	COG1324	tolerance protein
HEP74_RS19080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP74_RS19095	COG1733	regulation of RNA biosynthetic process
HEP74_RS19100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP74_RS19105	COG0511	ligase activity, forming carbon-carbon bonds
HEP74_RS19115	COG0439	Biotin carboxylase
HEP74_RS19125	COG0300	oxidoreductase activity
HEP74_RS19140	COG2264	protein methyltransferase activity
HEP74_RS19160	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HEP74_RS19165	COG4589	Belongs to the CDS family
HEP74_RS19190	COG0671	phosphoesterase, PA-phosphatase related
HEP74_RS19190	COG2453	phosphatase
HEP74_RS19195	COG2267	carboxylic ester hydrolase activity
HEP74_RS19200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP74_RS19205	COG0138	bifunctional purine biosynthesis protein purh
HEP74_RS19215	COG0151	Belongs to the GarS family
HEP74_RS19225	COG1289	transmembrane transporter activity
HEP74_RS19230	COG2814	Major facilitator Superfamily
HEP74_RS19345	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HEP74_RS19360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HEP74_RS19365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP74_RS19370	COG0730	response to heat
HEP74_RS19380	COG0134	indole-3-glycerol-phosphate synthase activity
HEP74_RS19390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP74_RS19420	COG1597	lipid kinase activity
HEP74_RS19435	COG0484	heat shock protein binding
HEP74_RS19445	COG2814	Major facilitator Superfamily
HEP74_RS19450	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HEP74_RS19470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_RS19475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP74_RS19475	COG2111	Na H antiporter
HEP74_RS19480	COG1006	Multisubunit Na H antiporter MnhC subunit
HEP74_RS19485	COG0651	ATP synthesis coupled electron transport
HEP74_RS19495	COG2212	antiporter activity
HEP74_RS19500	COG1320	monovalent cation:proton antiporter activity
HEP74_RS19525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP74_RS19550	COG3104	oligopeptide transport
HEP74_RS19565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP74_RS19590	COG3227	Zinc metalloprotease (Elastase)
HEP74_RS19595	COG0513	Belongs to the DEAD box helicase family
HEP74_RS19605	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS19615	COG0702	epimerase
HEP74_RS19620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP74_RS19630	COG2354	Protein conserved in bacteria
HEP74_RS19645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP74_RS19655	COG3264	Mechanosensitive ion channel
HEP74_RS19655	COG1196	nuclear chromosome segregation
HEP74_RS19660	COG0604	alcohol dehydrogenase
HEP74_RS19660	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS19660	COG3321	synthase
HEP74_RS19680	COG1595	DNA-templated transcription, initiation
HEP74_RS19700	COG1802	Transcriptional regulator
HEP74_RS19735	COG3052	prosthetic group binding
HEP74_RS19750	COG1414	Transcriptional regulator
HEP74_RS19755	COG0738	Major facilitator superfamily
HEP74_RS19760	COG3254	rhamnose metabolic process
HEP74_RS19770	COG4948	Mandelate Racemase Muconate Lactonizing
HEP74_RS19775	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP74_RS19780	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS19820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP74_RS19835	COG4807	Protein conserved in bacteria
HEP74_RS19890	COG5507	3-demethylubiquinone-9 3-methyltransferase
HEP74_RS19895	COG4773	Receptor
HEP74_RS19910	COG3220	belongs to the UPF0276 family
HEP74_RS20000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP74_RS20025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP74_RS20030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP74_RS20045	COG0753	catalase activity
HEP74_RS20065	COG4773	Receptor
HEP74_RS20070	COG2197	response regulator
HEP74_RS20075	COG4585	Histidine kinase
HEP74_RS20085	COG1131	(ABC) transporter
HEP74_RS20090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_RS20095	COG1136	(ABC) transporter
HEP74_RS20100	COG0577	efflux transmembrane transporter activity
HEP74_RS20115	COG2962	Rard protein
HEP74_RS20120	COG0697	spore germination
HEP74_RS20135	COG0180	Tryptophanyl-tRNA synthetase
HEP74_RS20145	COG3237	CsbD-like
HEP74_RS20180	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HEP74_RS20180	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HEP74_RS20220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP74_RS20225	COG3604	Transcriptional regulator
HEP74_RS20260	COG1222	aaa ATPase
HEP74_RS20360	COG2084	Dehydrogenase
HEP74_RS20365	COG1902	pentaerythritol trinitrate reductase activity
HEP74_RS20400	COG1404	Belongs to the peptidase S8 family
HEP74_RS20405	COG2814	Major facilitator Superfamily
HEP74_RS20410	COG0583	DNA-binding transcription factor activity
HEP74_RS20430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP74_RS20435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP74_RS20465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP74_RS20480	COG1764	response to oxidative stress
HEP74_RS20485	COG1846	Transcriptional regulator
HEP74_RS20495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEP74_RS20505	COG0697	spore germination
HEP74_RS20510	COG0523	cobalamin synthesis protein
HEP74_RS20525	COG3245	cytochrome
HEP74_RS20535	COG1960	acyl-CoA dehydrogenase activity
HEP74_RS20540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP74_RS20605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP74_RS20610	COG3387	PFAM Glycoside hydrolase 15-related
HEP74_RS20615	COG0745	RESPONSE REGULATOR receiver
HEP74_RS20630	COG1404	Belongs to the peptidase S8 family
HEP74_RS20640	COG3100	YcgL domain-containing protein
HEP74_RS20645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP74_RS20655	COG0463	Glycosyl transferase, family 2
HEP74_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_RS20695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP74_RS20710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP74_RS20735	COG1294	oxidase, subunit
HEP74_RS20740	COG1271	oxidase subunit
HEP74_RS20760	COG0408	coproporphyrinogen oxidase activity
HEP74_RS20770	COG2323	membrane
HEP74_RS20815	COG0515	serine threonine protein kinase
HEP74_RS20820	COG0631	protein serine/threonine phosphatase activity
HEP74_RS20930	COG0589	response to stress
HEP74_RS20945	COG3568	Endonuclease Exonuclease Phosphatase
HEP74_RS20955	COG0392	lysyltransferase activity
HEP74_RS20970	COG3275	phosphorelay sensor kinase activity
HEP74_RS20975	COG3279	Response regulator of the LytR AlgR family
HEP74_RS20985	COG0210	DNA helicase
HEP74_RS21065	COG0463	Glycosyl transferase, family 2
HEP74_RS21075	COG1475	DNA binding
HEP74_RS21080	COG1192	Involved in chromosome partitioning
HEP74_RS21085	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP74_RS21090	COG2091	lysine biosynthetic process via aminoadipic acid
HEP74_RS21115	COG1011	Hydrolase
HEP74_RS21120	COG0477	Major facilitator Superfamily
HEP74_RS21140	COG1971	Probably functions as a manganese efflux pump
HEP74_RS21155	COG0457	Tetratricopeptide repeat
HEP74_RS21160	COG2205	protein histidine kinase activity
HEP74_RS21170	COG5001	Diguanylate cyclase
HEP74_RS21175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP74_RS21180	COG3459	Glycosyltransferase 36 associated
HEP74_RS21185	COG2211	Major facilitator Superfamily
HEP74_RS21190	COG3265	gluconokinase activity
HEP74_RS21195	COG2094	Belongs to the DNA glycosylase MPG family
HEP74_RS21210	COG2911	Protein conserved in bacteria
HEP74_RS21215	COG0729	surface antigen
HEP74_RS21230	COG3132	Protein of unknown function, DUF480
HEP74_RS21260	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HEP74_RS21265	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP74_RS21280	COG1609	Transcriptional regulator
HEP74_RS21295	COG2937	Belongs to the GPAT DAPAT family
HEP74_RS21315	COG2211	Major facilitator Superfamily
HEP74_RS21330	COG3693	PFAM glycoside hydrolase, family 10
HEP74_RS21340	COG3250	beta-galactosidase activity
HEP74_RS21360	COG3386	PFAM SMP-30 Gluconolaconase
HEP74_RS21370	COG0667	Aldo Keto reductase
HEP74_RS21375	COG0583	DNA-binding transcription factor activity
HEP74_RS21430	COG0251	oxidation-reduction process
HEP74_RS21465	COG0246	Mannitol dehydrogenase
HEP74_RS21470	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_RS21480	COG4948	Mandelate Racemase Muconate Lactonizing
HEP74_RS21490	COG3661	Belongs to the glycosyl hydrolase 67 family
HEP74_RS21500	COG2115	Belongs to the xylose isomerase family
HEP74_RS21505	COG0037	tRNA processing
HEP74_RS21520	COG0840	transmembrane signaling receptor activity
HEP74_RS21530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEP74_RS21540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP74_RS21550	COG0805	protein transport
HEP74_RS21560	COG0519	Catalyzes the synthesis of GMP from XMP
HEP74_RS21560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP74_RS21585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP74_RS21600	COG0210	DNA helicase
HEP74_RS21605	COG1435	thymidine kinase activity
HEP74_RS21615	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEP74_RS21630	COG0515	serine threonine protein kinase
HEP74_RS21630	COG2815	serine threonine protein kinase
HEP74_RS21640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP74_RS21660	COG1119	ATPase activity
HEP74_RS21675	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HEP74_RS21685	COG1335	isochorismatase
HEP74_RS21705	COG1733	regulation of RNA biosynthetic process
HEP74_RS21725	COG0706	membrane insertase activity
HEP74_RS21730	COG0594	ribonuclease P activity