locus-tag	class	description
IG630_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IG630_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IG630_RS00020	COG0187	DNA topoisomerase II activity
IG630_RS00030	COG0501	Belongs to the peptidase M48B family
IG630_RS00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IG630_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG630_RS00115	COG0793	Belongs to the peptidase S41A family
IG630_RS00120	COG4942	peptidase
IG630_RS00130	COG2234	aminopeptidase activity
IG630_RS00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IG630_RS00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IG630_RS00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IG630_RS00165	COG1064	alcohol dehydrogenase
IG630_RS00175	COG0493	'glutamate synthase
IG630_RS00180	COG0069	glutamate synthase activity
IG630_RS00180	COG0070	glutamate synthase
IG630_RS00180	COG0067	glutamate synthase
IG630_RS00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IG630_RS00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IG630_RS00250	COG0438	transferase activity, transferring glycosyl groups
IG630_RS00250	COG0297	glycogen (starch) synthase activity
IG630_RS00270	COG0367	asparagine synthase
IG630_RS00300	COG1132	(ABC) transporter
IG630_RS00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IG630_RS00415	COG1111	helicase
IG630_RS00415	COG1205	dead DEAH box helicase
IG630_RS00420	COG1272	protein, Hemolysin III
IG630_RS00440	COG0300	oxidoreductase activity
IG630_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
IG630_RS00520	COG3237	CsbD-like
IG630_RS00565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG630_RS00570	COG0477	Major facilitator Superfamily
IG630_RS00610	COG0714	Associated with various cellular activities
IG630_RS00640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IG630_RS00650	COG4772	TonB-dependent receptor
IG630_RS00660	COG0662	Cupin 2, conserved barrel domain protein
IG630_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
IG630_RS00690	COG1304	FMN binding
IG630_RS00700	COG4585	Histidine kinase
IG630_RS00705	COG2197	response regulator
IG630_RS00725	COG3710	Transcriptional regulator
IG630_RS00730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IG630_RS00805	COG0366	Alpha amylase catalytic
IG630_RS00810	COG0366	Alpha amylase catalytic
IG630_RS00815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG630_RS00835	COG0657	acetylesterase activity
IG630_RS00835	COG2755	lipolytic protein G-D-S-L family
IG630_RS00845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG630_RS00860	COG3507	Belongs to the glycosyl hydrolase 43 family
IG630_RS00865	COG1609	Transcriptional regulator
IG630_RS00870	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IG630_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS00885	COG2755	lipolytic protein G-D-S-L family
IG630_RS00900	COG3186	Phenylalanine-4-hydroxylase
IG630_RS00905	COG1522	sequence-specific DNA binding
IG630_RS00915	COG1752	Esterase of the alpha-beta hydrolase superfamily
IG630_RS00925	COG1119	ATPase activity
IG630_RS00940	COG1125	glycine betaine transport
IG630_RS00955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG630_RS00975	COG1396	sequence-specific DNA binding
IG630_RS00995	COG0489	protein tyrosine kinase activity
IG630_RS01000	COG2062	phosphohistidine phosphatase, SixA
IG630_RS01010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG630_RS01055	COG1968	undecaprenyl-diphosphatase activity
IG630_RS01060	COG0174	glutamine synthetase
IG630_RS01065	COG0347	Belongs to the P(II) protein family
IG630_RS01070	COG0004	ammonium transporteR
IG630_RS01075	COG3852	Histidine kinase
IG630_RS01080	COG2204	response regulator
IG630_RS01085	COG2032	superoxide dismutase activity
IG630_RS01090	COG2032	superoxide dismutase activity
IG630_RS01100	COG0346	lactoylglutathione lyase activity
IG630_RS01110	COG0183	Belongs to the thiolase family
IG630_RS01145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG630_RS01150	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IG630_RS01155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IG630_RS01170	COG0028	Belongs to the TPP enzyme family
IG630_RS01175	COG2205	protein histidine kinase activity
IG630_RS01200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IG630_RS01215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG630_RS01225	COG0596	Alpha beta hydrolase
IG630_RS01230	COG0727	PFAM Uncharacterised protein family (UPF0153)
IG630_RS01235	COG0318	PFAM AMP-dependent synthetase and ligase
IG630_RS01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG630_RS01250	COG1181	Belongs to the D-alanine--D-alanine ligase family
IG630_RS01260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IG630_RS01270	COG0564	pseudouridine synthase activity
IG630_RS01295	COG0339	signal peptide processing
IG630_RS01325	COG0475	glutathione-regulated potassium exporter activity
IG630_RS01330	COG0583	DNA-binding transcription factor activity
IG630_RS01335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG630_RS01340	COG2224	Isocitrate lyase
IG630_RS01370	COG4770	biotin carboxylase activity
IG630_RS01375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG630_RS01380	COG1960	acyl-CoA dehydrogenase activity
IG630_RS01435	COG0523	cobalamin synthesis protein
IG630_RS01445	COG0697	spore germination
IG630_RS01455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IG630_RS01460	COG1846	Transcriptional regulator
IG630_RS01465	COG1764	response to oxidative stress
IG630_RS01490	COG2130	NADP-dependent
IG630_RS01505	COG1187	pseudouridine synthase activity
IG630_RS01520	COG1643	Atp-dependent helicase
IG630_RS01525	COG4807	Protein conserved in bacteria
IG630_RS01530	COG2351	hydroxyisourate hydrolase activity
IG630_RS01535	COG2072	flavoprotein involved in K transport
IG630_RS01555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IG630_RS01590	COG1957	nucleoside hydrolase
IG630_RS01600	COG2252	PERMEase
IG630_RS01620	COG0084	hydrolase, TatD family'
IG630_RS01635	COG0583	DNA-binding transcription factor activity
IG630_RS01640	COG2814	Major facilitator Superfamily
IG630_RS01655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IG630_RS01660	COG1902	pentaerythritol trinitrate reductase activity
IG630_RS01680	COG0745	RESPONSE REGULATOR receiver
IG630_RS01685	COG2205	protein histidine kinase activity
IG630_RS01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS01710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IG630_RS01715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IG630_RS01720	COG0583	DNA-binding transcription factor activity
IG630_RS01750	COG0702	epimerase
IG630_RS01755	COG1733	regulation of RNA biosynthetic process
IG630_RS01785	COG0129	dihydroxy-acid dehydratase activity
IG630_RS01800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IG630_RS01855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG630_RS01860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IG630_RS01885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IG630_RS01890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IG630_RS01900	COG3485	protocatechuate 3,4-dioxygenase
IG630_RS01905	COG3485	protocatechuate 3,4-dioxygenase
IG630_RS01915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG630_RS01920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG630_RS01930	COG1414	Transcriptional regulator
IG630_RS01940	COG0657	acetylesterase activity
IG630_RS01950	COG0445	tRNA wobble uridine modification
IG630_RS01960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG630_RS01990	COG2267	carboxylic ester hydrolase activity
IG630_RS02000	COG0156	8-amino-7-oxononanoate synthase activity
IG630_RS02005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IG630_RS02010	COG1040	competence protein
IG630_RS02015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IG630_RS02100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG630_RS02170	COG3264	Mechanosensitive ion channel
IG630_RS02170	COG1511	domain protein
IG630_RS02175	COG1368	sulfuric ester hydrolase activity
IG630_RS02180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IG630_RS02185	COG2354	Protein conserved in bacteria
IG630_RS02195	COG0297	glycogen (starch) synthase activity
IG630_RS02200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG630_RS02205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG630_RS02230	COG0702	epimerase
IG630_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG630_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS02280	COG0513	Belongs to the DEAD box helicase family
IG630_RS02305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IG630_RS02315	COG3483	tryptophan 2,3-dioxygenase activity
IG630_RS02320	COG3104	oligopeptide transport
IG630_RS02345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IG630_RS02360	COG1320	monovalent cation:proton antiporter activity
IG630_RS02365	COG2212	antiporter activity
IG630_RS02375	COG0651	ATP synthesis coupled electron transport
IG630_RS02380	COG1006	Multisubunit Na H antiporter MnhC subunit
IG630_RS02385	COG2111	Na H antiporter
IG630_RS02385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IG630_RS02405	COG3179	chitinase
IG630_RS02425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IG630_RS02430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IG630_RS02445	COG0456	acetyltransferase
IG630_RS02450	COG1597	lipid kinase activity
IG630_RS02475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IG630_RS02480	COG0134	indole-3-glycerol-phosphate synthase activity
IG630_RS02490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG630_RS02495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IG630_RS02505	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IG630_RS02515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IG630_RS02530	COG1051	belongs to the nudix hydrolase family
IG630_RS02570	COG0316	Belongs to the HesB IscA family
IG630_RS02590	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IG630_RS02605	COG2814	Major facilitator Superfamily
IG630_RS02610	COG0583	DNA-binding transcription factor activity
IG630_RS02615	COG2814	Major facilitator Superfamily
IG630_RS02620	COG1289	transmembrane transporter activity
IG630_RS02630	COG0151	Belongs to the GarS family
IG630_RS02640	COG0138	bifunctional purine biosynthesis protein purh
IG630_RS02645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IG630_RS02650	COG2267	carboxylic ester hydrolase activity
IG630_RS02655	COG2453	phosphatase
IG630_RS02655	COG0671	phosphoesterase, PA-phosphatase related
IG630_RS02680	COG4589	Belongs to the CDS family
IG630_RS02685	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IG630_RS02705	COG2264	protein methyltransferase activity
IG630_RS02725	COG0439	Biotin carboxylase
IG630_RS02735	COG0511	ligase activity, forming carbon-carbon bonds
IG630_RS02740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IG630_RS02750	COG1324	tolerance protein
IG630_RS02775	COG0300	oxidoreductase activity
IG630_RS02780	COG2356	endonuclease I
IG630_RS02795	COG0459	protein refolding
IG630_RS02810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IG630_RS02825	COG3386	PFAM SMP-30 Gluconolaconase
IG630_RS02835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IG630_RS02840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IG630_RS02855	COG0778	Nitroreductase
IG630_RS02860	COG2353	YceI-like domain
IG630_RS02890	COG3052	prosthetic group binding
IG630_RS02915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IG630_RS02925	COG1802	Transcriptional regulator
IG630_RS02980	COG4221	oxidoreductase activity
IG630_RS02995	COG4221	oxidoreductase activity
IG630_RS03005	COG0435	Glutathione S-transferase
IG630_RS03030	COG2409	Drug exporters of the RND superfamily
IG630_RS03035	COG0823	Involved in the tonB-independent uptake of proteins
IG630_RS03035	COG1506	peptidase
IG630_RS03075	COG0697	spore germination
IG630_RS03090	COG1113	amino acid transport
IG630_RS03110	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IG630_RS03145	COG5001	Diguanylate cyclase
IG630_RS03150	COG0840	transmembrane signaling receptor activity
IG630_RS03155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IG630_RS03155	COG5297	Belongs to the glycosyl hydrolase family 6
IG630_RS03160	COG0659	secondary active sulfate transmembrane transporter activity
IG630_RS03175	COG2943	transferase activity, transferring hexosyl groups
IG630_RS03185	COG3275	phosphorelay sensor kinase activity
IG630_RS03195	COG0181	hydroxymethylbilane synthase activity
IG630_RS03220	COG1505	serine-type exopeptidase activity
IG630_RS03225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IG630_RS03230	COG0436	Aminotransferase
IG630_RS03240	COG2832	Protein of unknown function (DUF454)
IG630_RS03250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IG630_RS03260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IG630_RS03265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IG630_RS03270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IG630_RS03295	COG2226	methyltransferase
IG630_RS03300	COG3300	MHYT domain
IG630_RS03300	COG5001	Diguanylate cyclase
IG630_RS03305	COG0308	aminopeptidase N
IG630_RS03350	COG3284	Transcriptional regulator
IG630_RS03355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG630_RS03360	COG1077	Cell shape determining protein MreB Mrl
IG630_RS03365	COG1792	Involved in formation and maintenance of cell shape
IG630_RS03380	COG0772	Belongs to the SEDS family
IG630_RS03390	COG2951	lytic endotransglycosylase activity
IG630_RS03395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IG630_RS03400	COG1686	Belongs to the peptidase S11 family
IG630_RS03410	COG2921	Belongs to the UPF0250 family
IG630_RS03415	COG0321	lipoyl(octanoyl) transferase activity
IG630_RS03420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IG630_RS03435	COG0583	DNA-binding transcription factor activity
IG630_RS03445	COG1051	belongs to the nudix hydrolase family
IG630_RS03445	COG1056	cytidyltransferase-related domain
IG630_RS03480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IG630_RS03485	COG0673	inositol 2-dehydrogenase activity
IG630_RS03490	COG2823	Periplasmic or secreted lipoprotein
IG630_RS03495	COG4251	negative regulation of phosphorylation
IG630_RS03500	COG0784	Response regulator, receiver
IG630_RS03505	COG4191	Histidine kinase
IG630_RS03510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IG630_RS03565	COG1459	type II secretion system
IG630_RS03630	COG2188	Transcriptional regulator
IG630_RS03640	COG1609	Transcriptional regulator
IG630_RS03645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IG630_RS03650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IG630_RS03660	COG0617	tRNA 3'-terminal CCA addition
IG630_RS03665	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IG630_RS03670	COG1012	belongs to the aldehyde dehydrogenase family
IG630_RS03675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IG630_RS03690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IG630_RS03705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IG630_RS03710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IG630_RS03725	COG2205	protein histidine kinase activity
IG630_RS03755	COG3791	Glutathione-dependent formaldehyde-activating
IG630_RS03765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG630_RS03775	COG0697	spore germination
IG630_RS03785	COG0488	(ABC) transporter
IG630_RS03795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG630_RS03800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IG630_RS03810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG630_RS03810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG630_RS03830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG630_RS03835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG630_RS03840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IG630_RS03860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IG630_RS03865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IG630_RS03870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IG630_RS03875	COG2205	protein histidine kinase activity
IG630_RS03880	COG0745	RESPONSE REGULATOR receiver
IG630_RS03895	COG0277	FAD linked oxidase domain protein
IG630_RS03900	COG1988	membrane-bound metal-dependent
IG630_RS03905	COG0792	nuclease activity
IG630_RS03940	COG0275	rRNA processing
IG630_RS03945	COG3116	cell division
IG630_RS03955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG630_RS03960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IG630_RS03965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG630_RS03975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IG630_RS03980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG630_RS03985	COG1181	Belongs to the D-alanine--D-alanine ligase family
IG630_RS03990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IG630_RS04005	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IG630_RS04015	COG0739	heme binding
IG630_RS04020	COG0653	protein targeting
IG630_RS04025	COG0494	nUDIX hydrolase
IG630_RS04035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IG630_RS04045	COG0604	alcohol dehydrogenase
IG630_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS04045	COG3321	synthase
IG630_RS04060	COG0366	Alpha amylase catalytic
IG630_RS04085	COG2226	methyltransferase
IG630_RS04090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IG630_RS04100	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IG630_RS04140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IG630_RS04150	COG4106	trans-aconitate 2-methyltransferase activity
IG630_RS04155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IG630_RS04165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG630_RS04170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IG630_RS04175	COG0667	Aldo Keto reductase
IG630_RS04185	COG4771	TonB-dependent receptor
IG630_RS04205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG630_RS04210	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IG630_RS04220	COG2175	clavaminate synthase activity
IG630_RS04230	COG4181	ATPase activity
IG630_RS04245	COG0642	Histidine kinase
IG630_RS04255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IG630_RS04275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IG630_RS04280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IG630_RS04295	COG3829	transcription factor binding
IG630_RS04305	COG1116	anion transmembrane transporter activity
IG630_RS04310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG630_RS04320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG630_RS04325	COG0431	NADPH-dependent FMN reductase
IG630_RS04350	COG0747	negative chemotaxis
IG630_RS04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG630_RS04370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IG630_RS04375	COG2967	ApaG domain
IG630_RS04380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IG630_RS04385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IG630_RS04390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG630_RS04395	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IG630_RS04410	COG0123	including yeast histone deacetylase and acetoin utilization protein
IG630_RS04415	COG2096	Adenosyltransferase
IG630_RS04430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG630_RS04435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG630_RS04465	COG3384	dioxygenase
IG630_RS04470	COG0583	DNA-binding transcription factor activity
IG630_RS04485	COG1024	Enoyl-CoA hydratase
IG630_RS04505	COG3386	PFAM SMP-30 Gluconolaconase
IG630_RS04520	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IG630_RS04545	COG0697	spore germination
IG630_RS04550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG630_RS04570	COG0784	Response regulator, receiver
IG630_RS04570	COG5002	protein histidine kinase activity
IG630_RS04570	COG2205	protein histidine kinase activity
IG630_RS04575	COG2197	response regulator
IG630_RS04585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG630_RS04595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IG630_RS04600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG630_RS04605	COG0583	DNA-binding transcription factor activity
IG630_RS04610	COG3634	alkyl hydroperoxide reductase activity
IG630_RS04620	COG2890	protein-(glutamine-N5) methyltransferase activity
IG630_RS04640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IG630_RS04640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IG630_RS04670	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IG630_RS04700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IG630_RS04715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IG630_RS04720	COG1404	Belongs to the peptidase S8 family
IG630_RS04725	COG1404	Belongs to the peptidase S8 family
IG630_RS04730	COG1404	Belongs to the peptidase S8 family
IG630_RS04735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IG630_RS04760	COG1295	ribonuclease BN
IG630_RS04765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG630_RS04770	COG1254	Belongs to the acylphosphatase family
IG630_RS04785	COG0521	Mo-molybdopterin cofactor biosynthetic process
IG630_RS04795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IG630_RS04800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IG630_RS04810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IG630_RS04815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IG630_RS04825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IG630_RS04830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IG630_RS04835	COG0193	aminoacyl-tRNA hydrolase activity
IG630_RS04840	COG0012	GTP binding
IG630_RS04860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG630_RS04875	COG0250	Participates in transcription elongation, termination and antitermination
IG630_RS04880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IG630_RS04885	COG0081	regulation of translation
IG630_RS04890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IG630_RS04895	COG0222	ribosome binding
IG630_RS04900	COG0085	RNA polymerase activity
IG630_RS04905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IG630_RS04910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IG630_RS04915	COG0049	tRNA binding
IG630_RS04920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG630_RS04925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG630_RS04930	COG0051	transcription antitermination factor activity, RNA binding
IG630_RS04935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IG630_RS04940	COG0088	Forms part of the polypeptide exit tunnel
IG630_RS04945	COG0089	rRNA binding
IG630_RS04950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IG630_RS04955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IG630_RS04965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IG630_RS04970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IG630_RS04975	COG0255	Belongs to the universal ribosomal protein uL29 family
IG630_RS04980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IG630_RS04990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IG630_RS04995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IG630_RS05005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IG630_RS05010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IG630_RS05015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IG630_RS05025	COG1841	ribosomal large subunit assembly
IG630_RS05030	COG0200	Binds to the 23S rRNA
IG630_RS05035	COG0201	protein transport
IG630_RS05060	COG0203	ribosomal protein L17
IG630_RS05065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IG630_RS05080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IG630_RS05090	COG0154	amidase activity
IG630_RS05100	COG1217	gtp-binding protein TYPA
IG630_RS05105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IG630_RS05110	COG0039	L-malate dehydrogenase activity
IG630_RS05115	COG0625	glutathione transferase activity
IG630_RS05125	COG1902	pentaerythritol trinitrate reductase activity
IG630_RS05125	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG630_RS05130	COG0604	alcohol dehydrogenase
IG630_RS05155	COG0156	8-amino-7-oxononanoate synthase activity
IG630_RS05160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IG630_RS05165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IG630_RS05170	COG4208	sulfate ABC transporter
IG630_RS05175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IG630_RS05185	COG1063	alcohol dehydrogenase
IG630_RS05215	COG0406	alpha-ribazole phosphatase activity
IG630_RS05220	COG0285	dihydrofolate synthase activity
IG630_RS05240	COG2833	Protein of unknown function (DUF455)
IG630_RS05250	COG3291	Pkd domain containing protein
IG630_RS05260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG630_RS05265	COG0671	phosphoesterase, PA-phosphatase related
IG630_RS05270	COG0438	transferase activity, transferring glycosyl groups
IG630_RS05280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IG630_RS05295	COG4783	chaperone-mediated protein folding
IG630_RS05310	COG0473	3-isopropylmalate dehydrogenase activity
IG630_RS05465	COG0544	peptidyl-prolyl cis-trans isomerase activity
IG630_RS05475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IG630_RS05505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG630_RS05515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG630_RS05525	COG0328	RNA-DNA hybrid ribonuclease activity
IG630_RS05530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IG630_RS05535	COG0631	protein serine/threonine phosphatase activity
IG630_RS05550	COG0859	PFAM glycosyl transferase family 9
IG630_RS05555	COG3642	lipopolysaccharide core region biosynthetic process
IG630_RS05560	COG1234	tRNA 3'-trailer cleavage
IG630_RS05565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IG630_RS05575	COG0315	cyclic pyranopterin monophosphate synthase activity
IG630_RS05580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IG630_RS05585	COG0314	molybdopterin synthase activity
IG630_RS05635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IG630_RS05640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IG630_RS05645	COG0537	adenosine 5'-monophosphoramidase activity
IG630_RS05665	COG0714	Associated with various cellular activities
IG630_RS05685	COG0424	maF-like protein
IG630_RS05690	COG1399	metal-binding, possibly nucleic acid-binding protein
IG630_RS05695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IG630_RS05700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG630_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS05730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IG630_RS05735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IG630_RS05760	COG3829	transcription factor binding
IG630_RS05780	COG3609	addiction module antidote protein, CC2985 family
IG630_RS05810	COG2373	Large extracellular alpha-helical protein
IG630_RS05825	COG4953	penicillin-binding protein 1C
IG630_RS05835	COG0678	peroxiredoxin activity
IG630_RS05855	COG0330	HflC and HflK could
IG630_RS05860	COG0330	HflC and HflK could
IG630_RS05870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IG630_RS05875	COG0308	aminopeptidase N
IG630_RS05880	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS05885	COG1309	transcriptional regulator
IG630_RS05965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IG630_RS05975	COG3387	PFAM Glycoside hydrolase 15-related
IG630_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS05985	COG3537	Alpha-1,2-mannosidase
IG630_RS06005	COG0492	ferredoxin-NADP+ reductase activity
IG630_RS06030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG630_RS06035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IG630_RS06040	COG2080	2 iron, 2 sulfur cluster binding
IG630_RS06075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IG630_RS06090	COG0587	DNA-directed DNA polymerase activity
IG630_RS06110	COG1297	OPT oligopeptide transporter protein
IG630_RS06125	COG1506	peptidase
IG630_RS06125	COG0823	Involved in the tonB-independent uptake of proteins
IG630_RS06140	COG1917	Cupin 2, conserved barrel domain protein
IG630_RS06140	COG2207	Transcriptional regulator
IG630_RS06155	COG0753	catalase activity
IG630_RS06160	COG0656	L-ascorbic acid biosynthetic process
IG630_RS06170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG630_RS06170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG630_RS06175	COG2814	Major facilitator Superfamily
IG630_RS06190	COG2194	sulfuric ester hydrolase activity
IG630_RS06205	COG0745	RESPONSE REGULATOR receiver
IG630_RS06210	COG0642	Histidine kinase
IG630_RS06220	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IG630_RS06225	COG2894	cell division
IG630_RS06230	COG0850	regulation of cytokinetic process
IG630_RS06240	COG4585	Histidine kinase
IG630_RS06245	COG2197	response regulator
IG630_RS06260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IG630_RS06285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IG630_RS06295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IG630_RS06315	COG1946	Acyl-CoA thioesterase
IG630_RS06330	COG0824	Thioesterase
IG630_RS06335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IG630_RS06340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IG630_RS06345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IG630_RS06350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IG630_RS06355	COG0268	Binds directly to 16S ribosomal RNA
IG630_RS06365	COG0196	riboflavin kinase activity
IG630_RS06370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IG630_RS06375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IG630_RS06380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IG630_RS06395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG630_RS06400	COG1845	cytochrome c oxidase, subunit III
IG630_RS06405	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IG630_RS06420	COG3152	Membrane
IG630_RS06430	COG2207	Transcriptional regulator
IG630_RS06435	COG0326	Molecular chaperone. Has ATPase activity
IG630_RS06445	COG1366	Belongs to the anti-sigma-factor antagonist family
IG630_RS06450	COG1366	Belongs to the anti-sigma-factor antagonist family
IG630_RS06455	COG2172	sigma factor antagonist activity
IG630_RS06480	COG4771	TonB-dependent receptor
IG630_RS06490	COG5507	3-demethylubiquinone-9 3-methyltransferase
IG630_RS06495	COG2205	protein histidine kinase activity
IG630_RS06505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IG630_RS06510	COG4999	Histidine kinase
IG630_RS06510	COG3850	Histidine kinase
IG630_RS06510	COG3437	response regulator, receiver
IG630_RS06510	COG2205	protein histidine kinase activity
IG630_RS06515	COG0784	Response regulator, receiver
IG630_RS06515	COG4191	Histidine kinase
IG630_RS06545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG630_RS06550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IG630_RS06560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IG630_RS06565	COG0228	four-way junction DNA binding
IG630_RS06570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IG630_RS06575	COG0336	Belongs to the RNA methyltransferase TrmD family
IG630_RS06580	COG0335	large ribosomal subunit rRNA binding
IG630_RS06605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IG630_RS06615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IG630_RS06625	COG3209	COG3209 Rhs family protein
IG630_RS06645	COG3250	beta-galactosidase activity
IG630_RS06650	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IG630_RS06670	COG1960	acyl-CoA dehydrogenase activity
IG630_RS06675	COG1024	Enoyl-CoA hydratase
IG630_RS06695	COG1024	Enoyl-CoA hydratase
IG630_RS06695	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG630_RS06710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG630_RS06715	COG0481	GTPase activity
IG630_RS06730	COG0571	ribonuclease III activity
IG630_RS06735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IG630_RS06740	COG1381	Involved in DNA repair and RecF pathway recombination
IG630_RS06750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IG630_RS06755	COG2954	triphosphatase activity
IG630_RS06760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IG630_RS06765	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IG630_RS06770	COG3046	protein related to deoxyribodipyrimidine photolyase
IG630_RS06775	COG1472	Belongs to the glycosyl hydrolase 3 family
IG630_RS06780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IG630_RS06785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IG630_RS06790	COG1278	Cold shock
IG630_RS06795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG630_RS06805	COG1201	RNA secondary structure unwinding
IG630_RS06810	COG1793	dna ligase
IG630_RS06820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IG630_RS06820	COG1793	dna ligase
IG630_RS06850	COG0183	Belongs to the thiolase family
IG630_RS06875	COG1451	nucleotide metabolic process
IG630_RS06880	COG5487	UPF0391 membrane protein
IG630_RS06890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IG630_RS06905	COG1077	Cell shape determining protein MreB Mrl
IG630_RS06910	COG1047	Peptidyl-prolyl cis-trans
IG630_RS06920	COG2824	Alkylphosphonate utilization operon protein PhnA
IG630_RS06925	COG1902	pentaerythritol trinitrate reductase activity
IG630_RS06930	COG2814	Major facilitator Superfamily
IG630_RS06965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IG630_RS06965	COG0392	lysyltransferase activity
IG630_RS06975	COG0251	oxidation-reduction process
IG630_RS06980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG630_RS06995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG630_RS07020	COG1595	DNA-templated transcription, initiation
IG630_RS07035	COG2878	Part of a membrane complex involved in electron transport
IG630_RS07045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG630_RS07045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG630_RS07060	COG1131	(ABC) transporter
IG630_RS07065	COG0346	lactoylglutathione lyase activity
IG630_RS07070	COG0833	amino acid
IG630_RS07075	COG2040	homocysteine
IG630_RS07085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IG630_RS07105	COG1695	Transcriptional regulator
IG630_RS07125	COG1981	membrane
IG630_RS07140	COG0825	malonyl-CoA metabolic process
IG630_RS07150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IG630_RS07155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG630_RS07160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG630_RS07165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG630_RS07170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG630_RS07185	COG0750	zinc metalloprotease
IG630_RS07190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IG630_RS07195	COG0575	Belongs to the CDS family
IG630_RS07200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IG630_RS07205	COG0233	cytoplasmic translational termination
IG630_RS07210	COG0528	UMP kinase activity
IG630_RS07220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IG630_RS07225	COG0052	Belongs to the universal ribosomal protein uS2 family
IG630_RS07265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IG630_RS07275	COG1393	Belongs to the ArsC family
IG630_RS07280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG630_RS07285	COG0367	asparagine synthase
IG630_RS07295	COG4774	siderophore transport
IG630_RS07310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IG630_RS07340	COG1566	PFAM secretion protein HlyD family protein
IG630_RS07345	COG2814	Major facilitator Superfamily
IG630_RS07395	COG0339	signal peptide processing
IG630_RS07400	COG0386	Belongs to the glutathione peroxidase family
IG630_RS07455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IG630_RS07475	COG1960	acyl-CoA dehydrogenase activity
IG630_RS07490	COG0367	asparagine synthase
IG630_RS07500	COG0305	Participates in initiation and elongation during chromosome replication
IG630_RS07505	COG0415	Belongs to the DNA photolyase family
IG630_RS07515	COG0583	DNA-binding transcription factor activity
IG630_RS07560	COG3706	GGDEF domain
IG630_RS07715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IG630_RS07730	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG630_RS07740	COG0497	DNA recombination
IG630_RS07745	COG1420	regulation of RNA biosynthetic process
IG630_RS07750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IG630_RS07755	COG0443	Heat shock 70 kDa protein
IG630_RS07760	COG0484	heat shock protein binding
IG630_RS07770	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IG630_RS07800	COG0583	DNA-binding transcription factor activity
IG630_RS07805	COG1132	(ABC) transporter
IG630_RS07840	COG2850	peptidyl-arginine hydroxylation
IG630_RS07860	COG1253	flavin adenine dinucleotide binding
IG630_RS07890	COG1131	(ABC) transporter
IG630_RS07895	COG1725	Transcriptional regulator
IG630_RS07905	COG0386	Belongs to the glutathione peroxidase family
IG630_RS07920	COG2900	Belongs to the SlyX family
IG630_RS07945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG630_RS07955	COG0646	methionine synthase
IG630_RS07955	COG1410	methionine synthase
IG630_RS07960	COG0646	methionine synthase
IG630_RS07960	COG1410	methionine synthase
IG630_RS07965	COG2226	methyltransferase
IG630_RS07970	COG1960	acyl-CoA dehydrogenase activity
IG630_RS07975	COG1960	acyl-CoA dehydrogenase activity
IG630_RS07980	COG1960	acyl-CoA dehydrogenase activity
IG630_RS07985	COG1960	acyl-CoA dehydrogenase activity
IG630_RS08000	COG0557	exoribonuclease II activity
IG630_RS08010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG630_RS08020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IG630_RS08030	COG0704	Plays a role in the regulation of phosphate uptake
IG630_RS08035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IG630_RS08040	COG0581	inorganic phosphate transmembrane transporter activity
IG630_RS08045	COG0573	inorganic phosphate transmembrane transporter activity
IG630_RS08050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IG630_RS08075	COG0659	secondary active sulfate transmembrane transporter activity
IG630_RS08080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IG630_RS08090	COG1024	Enoyl-CoA hydratase
IG630_RS08100	COG0494	nUDIX hydrolase
IG630_RS08135	COG0488	(ABC) transporter
IG630_RS08145	COG0116	Belongs to the methyltransferase superfamily
IG630_RS08145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IG630_RS08150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IG630_RS08175	COG2925	Exonuclease
IG630_RS08185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG630_RS08190	COG3844	kynureninase activity
IG630_RS08200	COG0662	Cupin 2, conserved barrel domain protein
IG630_RS08205	COG0288	reversible hydration of carbon dioxide
IG630_RS08270	COG2808	Putative FMN-binding domain
IG630_RS08290	COG0017	Asparaginyl-tRNA synthetase
IG630_RS08295	COG0316	Belongs to the HesB IscA family
IG630_RS08300	COG0360	Binds together with S18 to 16S ribosomal RNA
IG630_RS08305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IG630_RS08310	COG0359	binds to the 23S rRNA
IG630_RS08320	COG3115	cell septum assembly
IG630_RS08330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG630_RS08335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IG630_RS08340	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IG630_RS08355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IG630_RS08375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IG630_RS08385	COG2986	histidine ammonia-lyase
IG630_RS08390	COG1228	amidohydrolase
IG630_RS08435	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IG630_RS08440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG630_RS08445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IG630_RS08450	COG0077	Prephenate dehydratase
IG630_RS08450	COG1605	Chorismate mutase
IG630_RS08455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IG630_RS08470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IG630_RS08475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG630_RS08480	COG0583	DNA-binding transcription factor activity
IG630_RS08545	COG0840	transmembrane signaling receptor activity
IG630_RS08570	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IG630_RS08575	COG4191	Histidine kinase
IG630_RS08575	COG0784	Response regulator, receiver
IG630_RS08590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG630_RS08600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IG630_RS08610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG630_RS08625	COG1595	DNA-templated transcription, initiation
IG630_RS08675	COG2244	polysaccharide biosynthetic process
IG630_RS08705	COG2264	protein methyltransferase activity
IG630_RS08715	COG0438	transferase activity, transferring glycosyl groups
IG630_RS08730	COG1136	(ABC) transporter
IG630_RS08740	COG0477	Major facilitator Superfamily
IG630_RS08745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG630_RS08760	COG1253	flavin adenine dinucleotide binding
IG630_RS08770	COG0306	phosphate transporter
IG630_RS08795	COG0504	CTP synthase activity
IG630_RS08800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IG630_RS08810	COG0148	phosphopyruvate hydratase activity
IG630_RS08815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IG630_RS08820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IG630_RS08825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IG630_RS08830	COG0585	pseudouridine synthase activity
IG630_RS08835	COG2840	Smr protein MutS2
IG630_RS08840	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IG630_RS08845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG630_RS08850	COG1238	metal cluster binding
IG630_RS08865	COG1534	Rna-binding protein
IG630_RS08870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IG630_RS08880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IG630_RS08885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IG630_RS08895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IG630_RS08900	COG1546	Belongs to the CinA family
IG630_RS08910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IG630_RS08915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IG630_RS08920	COG2137	regulation of response to DNA damage stimulus
IG630_RS08925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG630_RS08930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IG630_RS08945	COG1741	Belongs to the pirin family
IG630_RS08950	COG0583	DNA-binding transcription factor activity
IG630_RS08975	COG0351	phosphomethylpyrimidine kinase
IG630_RS08975	COG0352	thiamine-phosphate diphosphorylase activity
IG630_RS08990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IG630_RS08995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IG630_RS09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG630_RS09020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IG630_RS09025	COG3734	2-keto-3-deoxy-galactonokinase
IG630_RS09035	COG4948	Mandelate Racemase Muconate Lactonizing
IG630_RS09040	COG0800	Aldolase
IG630_RS09075	COG1501	Belongs to the glycosyl hydrolase 31 family
IG630_RS09085	COG1070	Carbohydrate kinase
IG630_RS09095	COG0477	Major facilitator Superfamily
IG630_RS09115	COG0860	N-Acetylmuramoyl-L-alanine amidase
IG630_RS09120	COG1469	GTP cyclohydrolase I activity
IG630_RS09140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IG630_RS09145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IG630_RS09150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IG630_RS09155	COG0166	Belongs to the GPI family
IG630_RS09175	COG1472	Belongs to the glycosyl hydrolase 3 family
IG630_RS09185	COG5001	Diguanylate cyclase
IG630_RS09185	COG4251	negative regulation of phosphorylation
IG630_RS09185	COG2203	Gaf domain
IG630_RS09185	COG3706	GGDEF domain
IG630_RS09195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IG630_RS09200	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IG630_RS09210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IG630_RS09215	COG0671	phosphoesterase, PA-phosphatase related
IG630_RS09230	COG1794	racemase activity, acting on amino acids and derivatives
IG630_RS09235	COG0697	spore germination
IG630_RS09240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IG630_RS09245	COG0167	dihydroorotate dehydrogenase activity
IG630_RS09260	COG1012	belongs to the aldehyde dehydrogenase family
IG630_RS09275	COG1215	transferase activity, transferring glycosyl groups
IG630_RS09280	COG0726	polysaccharide deacetylase
IG630_RS09280	COG1649	PFAM Uncharacterised BCR, COG1649
IG630_RS09295	COG3210	domain, Protein
IG630_RS09305	COG3210	domain, Protein
IG630_RS09355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG630_RS09360	COG0124	histidyl-tRNA synthetase
IG630_RS09370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IG630_RS09375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IG630_RS09380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG630_RS09385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IG630_RS09385	COG0131	Imidazoleglycerol-phosphate dehydratase
IG630_RS09390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IG630_RS09395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IG630_RS09400	COG0107	imidazoleglycerol-phosphate synthase activity
IG630_RS09405	COG0140	phosphoribosyl-ATP diphosphatase activity
IG630_RS09405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IG630_RS09420	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IG630_RS09425	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IG630_RS09430	COG0235	Class ii aldolase
IG630_RS09435	COG0531	amino acid
IG630_RS09440	COG0531	amino acid
IG630_RS09450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG630_RS09455	COG0277	FAD linked oxidase domain protein
IG630_RS09475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IG630_RS09520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG630_RS09525	COG2258	MOSC domain
IG630_RS09530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IG630_RS09535	COG0505	Belongs to the CarA family
IG630_RS09545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IG630_RS09550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG630_RS09560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IG630_RS09600	COG3279	Response regulator of the LytR AlgR family
IG630_RS09610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IG630_RS09620	COG2205	protein histidine kinase activity
IG630_RS09620	COG2198	Histidine kinase
IG630_RS09620	COG0784	Response regulator, receiver
IG630_RS09625	COG1024	Enoyl-CoA hydratase
IG630_RS09630	COG0318	PFAM AMP-dependent synthetase and ligase
IG630_RS09660	COG2267	carboxylic ester hydrolase activity
IG630_RS09670	COG2201	protein-glutamate methylesterase activity
IG630_RS09675	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IG630_RS09685	COG0840	transmembrane signaling receptor activity
IG630_RS09690	COG0840	transmembrane signaling receptor activity
IG630_RS09695	COG0840	transmembrane signaling receptor activity
IG630_RS09700	COG0840	transmembrane signaling receptor activity
IG630_RS09705	COG0840	transmembrane signaling receptor activity
IG630_RS09710	COG0840	transmembrane signaling receptor activity
IG630_RS09715	COG0840	transmembrane signaling receptor activity
IG630_RS09725	COG0840	transmembrane signaling receptor activity
IG630_RS09745	COG0840	transmembrane signaling receptor activity
IG630_RS09750	COG2198	Histidine kinase
IG630_RS09750	COG0643	Histidine kinase
IG630_RS09755	COG0745	RESPONSE REGULATOR receiver
IG630_RS09765	COG0835	chemotaxis
IG630_RS09775	COG1360	Flagellar Motor Protein
IG630_RS09780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IG630_RS09865	COG0641	radical SAM
IG630_RS09880	COG0784	Response regulator, receiver
IG630_RS09880	COG2198	Histidine kinase
IG630_RS09880	COG0643	Histidine kinase
IG630_RS09910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG630_RS09935	COG1684	flagellar biosynthetic protein fliR
IG630_RS09950	COG3190	flagellar
IG630_RS10000	COG1677	Flagellar hook-basal body complex protein FliE
IG630_RS10030	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS10035	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS10040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG630_RS10060	COG2201	protein-glutamate methylesterase activity
IG630_RS10090	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IG630_RS10100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG630_RS10105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG630_RS10115	COG3951	Flagellar rod assembly protein muramidase FlgJ
IG630_RS10115	COG1705	Flagellar rod assembly protein muramidase FlgJ
IG630_RS10120	COG1706	bacterial-type flagellum-dependent cell motility
IG630_RS10125	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IG630_RS10135	COG4787	bacterial-type flagellum-dependent cell motility
IG630_RS10145	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IG630_RS10150	COG1558	bacterial-type flagellum-dependent cell motility
IG630_RS10160	COG0835	chemotaxis
IG630_RS10160	COG0784	Response regulator, receiver
IG630_RS10180	COG5002	protein histidine kinase activity
IG630_RS10210	COG2915	High frequency lysogenization protein hflD homolog
IG630_RS10215	COG0482	sulfurtransferase activity
IG630_RS10230	COG0542	response to heat
IG630_RS10240	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IG630_RS10250	COG0492	ferredoxin-NADP+ reductase activity
IG630_RS10255	COG1674	ftsk spoiiie
IG630_RS10265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IG630_RS10275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IG630_RS10280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG630_RS10285	COG0183	Belongs to the thiolase family
IG630_RS10290	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG630_RS10290	COG1024	Enoyl-CoA hydratase
IG630_RS10305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IG630_RS10315	COG1426	Protein conserved in bacteria
IG630_RS10325	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG630_RS10330	COG1160	GTP binding
IG630_RS10335	COG0303	'Molybdopterin
IG630_RS10340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IG630_RS10375	COG0708	Exodeoxyribonuclease III
IG630_RS10385	COG0303	'Molybdopterin
IG630_RS10390	COG0746	molybdenum cofactor guanylyltransferase activity
IG630_RS10405	COG1914	H( )-stimulated, divalent metal cation uptake system
IG630_RS10420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IG630_RS10425	COG0668	transmembrane transport
IG630_RS10435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IG630_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS10455	COG1183	phosphatidylcholine synthase activity
IG630_RS10465	COG3243	poly(R)-hydroxyalkanoic acid synthase
IG630_RS10480	COG0723	plastoquinol--plastocyanin reductase activity
IG630_RS10480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG630_RS10490	COG2183	response to ionizing radiation
IG630_RS10495	COG2205	protein histidine kinase activity
IG630_RS10495	COG0784	Response regulator, receiver
IG630_RS10565	COG0800	Aldolase
IG630_RS10570	COG0129	dihydroxy-acid dehydratase activity
IG630_RS10575	COG0363	glucosamine-6-phosphate deaminase activity
IG630_RS10580	COG0837	glucose binding
IG630_RS10585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IG630_RS10610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IG630_RS10625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IG630_RS10630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IG630_RS10640	COG4591	ABC-type transport system involved in lipoprotein release permease component
IG630_RS10645	COG1136	(ABC) transporter
IG630_RS10660	COG0811	peptide transport
IG630_RS10670	COG1132	(ABC) transporter
IG630_RS10675	COG1663	tetraacyldisaccharide 4'-kinase activity
IG630_RS10680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IG630_RS10685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG630_RS10695	COG0322	excinuclease ABC activity
IG630_RS10700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IG630_RS10725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IG630_RS10730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IG630_RS10745	COG0582	viral genome integration into host DNA
IG630_RS10755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IG630_RS10775	COG1054	Belongs to the UPF0176 family
IG630_RS10785	COG1530	ribonuclease E activity
IG630_RS10795	COG3064	Membrane
IG630_RS10800	COG0428	transporter
IG630_RS10810	COG2154	pterin-4-alpha-carbinolamine dehydratase
IG630_RS10815	COG0316	Belongs to the HesB IscA family
IG630_RS10815	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IG630_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS10990	COG1238	metal cluster binding
IG630_RS11025	COG3279	Response regulator of the LytR AlgR family
IG630_RS11065	COG4566	intracellular signal transduction
IG630_RS11075	COG5001	Diguanylate cyclase
IG630_RS11095	COG3685	Protein conserved in bacteria
IG630_RS11120	COG1648	precorrin-2 dehydrogenase activity
IG630_RS11120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IG630_RS11135	COG2814	Major facilitator Superfamily
IG630_RS11150	COG1335	isochorismatase
IG630_RS11170	COG2197	response regulator
IG630_RS11190	COG0583	DNA-binding transcription factor activity
IG630_RS11195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IG630_RS11200	COG3002	Belongs to the UPF0753 family
IG630_RS11210	COG1396	sequence-specific DNA binding
IG630_RS11215	COG5489	Protein of unknown function (DUF736)
IG630_RS11225	COG2003	Belongs to the UPF0758 family
IG630_RS11250	COG0582	viral genome integration into host DNA
IG630_RS11265	COG4774	siderophore transport
IG630_RS11285	COG2336	PFAM SpoVT AbrB
IG630_RS11310	COG4206	TonB-dependent receptor
IG630_RS11350	COG2274	protein secretion by the type I secretion system
IG630_RS11400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IG630_RS11405	COG0270	DNA (cytosine-5-)-methyltransferase activity
IG630_RS11465	COG5006	permease, DMT superfamily
IG630_RS11480	COG2249	NAD(P)H dehydrogenase (quinone) activity
IG630_RS11490	COG3938	Belongs to the proline racemase family
IG630_RS11505	COG2807	transmembrane transport
IG630_RS11510	COG2207	Transcriptional regulator
IG630_RS11650	COG0210	DNA helicase
IG630_RS11730	COG2084	Dehydrogenase
IG630_RS11750	COG2003	Belongs to the UPF0758 family
IG630_RS11785	COG0582	viral genome integration into host DNA
IG630_RS11790	COG0519	Catalyzes the synthesis of GMP from XMP
IG630_RS11790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG630_RS11800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG630_RS11810	COG0475	glutathione-regulated potassium exporter activity
IG630_RS11810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG630_RS11815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IG630_RS11825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG630_RS11830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IG630_RS11840	COG0776	regulation of translation
IG630_RS11845	COG0539	negative regulation of cytoplasmic translation
IG630_RS11850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IG630_RS11865	COG2957	Belongs to the agmatine deiminase family
IG630_RS11870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG630_RS11895	COG0395	ABC-type sugar transport system, permease component
IG630_RS11900	COG1175	transmembrane transport
IG630_RS11930	COG2350	Protein conserved in bacteria
IG630_RS11935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IG630_RS11940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG630_RS11945	COG1187	pseudouridine synthase activity
IG630_RS11965	COG0436	Aminotransferase
IG630_RS11970	COG4133	protoheme IX ABC transporter activity
IG630_RS11990	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IG630_RS11995	COG1138	Cytochrome C-type biogenesis protein
IG630_RS12015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG630_RS12020	COG1278	Cold shock
IG630_RS12025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IG630_RS12030	COG4988	ABC transporter
IG630_RS12040	COG1294	oxidase, subunit
IG630_RS12065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IG630_RS12070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IG630_RS12080	COG0165	Argininosuccinate lyase
IG630_RS12085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IG630_RS12095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IG630_RS12100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG630_RS12110	COG0137	argininosuccinate synthase activity
IG630_RS12115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG630_RS12125	COG0215	cysteine-tRNA ligase activity
IG630_RS12130	COG2166	iron-sulfur cluster assembly
IG630_RS12145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IG630_RS12150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG630_RS12180	COG4302	ethanolamine ammonia-lyase activity
IG630_RS12235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG630_RS12240	COG0402	S-adenosylhomocysteine deaminase activity
IG630_RS12250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IG630_RS12255	COG1509	lysine 2,3-aminomutase activity
IG630_RS12260	COG5001	Diguanylate cyclase
IG630_RS12260	COG3300	MHYT domain
IG630_RS12275	COG0483	inositol monophosphate 1-phosphatase activity
IG630_RS12280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IG630_RS12295	COG0488	(ABC) transporter
IG630_RS12300	COG0513	Belongs to the DEAD box helicase family
IG630_RS12305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IG630_RS12310	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IG630_RS12320	COG0625	glutathione transferase activity
IG630_RS12330	COG4681	YaeQ
IG630_RS12335	COG2081	HI0933 family
IG630_RS12345	COG0501	Belongs to the peptidase M48B family
IG630_RS12350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG630_RS12355	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS12380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IG630_RS12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
IG630_RS12390	COG0802	atpase or kinase
IG630_RS12395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IG630_RS12395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IG630_RS12400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IG630_RS12405	COG1570	exodeoxyribonuclease VII activity
IG630_RS12415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG630_RS12595	COG0835	chemotaxis
IG630_RS12600	COG0840	transmembrane signaling receptor activity
IG630_RS12605	COG2094	Belongs to the DNA glycosylase MPG family
IG630_RS12610	COG1201	RNA secondary structure unwinding
IG630_RS12630	COG2969	positive regulation of protein catabolic process
IG630_RS12635	COG0625	glutathione transferase activity
IG630_RS12640	COG2857	Cytochrome c1
IG630_RS12645	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IG630_RS12650	COG0723	plastoquinol--plastocyanin reductase activity
IG630_RS12655	COG0741	lytic transglycosylase activity
IG630_RS12670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG630_RS12675	COG1702	phosphate starvation-inducible protein PhoH
IG630_RS12685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IG630_RS12695	COG4535	Mg2 and Co2 transporter CorC
IG630_RS12710	COG1012	belongs to the aldehyde dehydrogenase family
IG630_RS12715	COG1177	transmembrane transport
IG630_RS12720	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG630_RS12725	COG3842	ATPase activity
IG630_RS12745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IG630_RS12760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IG630_RS12765	COG0174	glutamine synthetase
IG630_RS12770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG630_RS12780	COG2703	oxygen carrier activity
IG630_RS12785	COG0477	Major facilitator Superfamily
IG630_RS12795	COG0243	molybdopterin cofactor binding
IG630_RS12800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG630_RS12805	COG2223	nitrite transmembrane transporter activity
IG630_RS12810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG630_RS12820	COG2733	membrane
IG630_RS12825	COG2205	protein histidine kinase activity
IG630_RS12825	COG0784	Response regulator, receiver
IG630_RS12825	COG5002	protein histidine kinase activity
IG630_RS12835	COG0477	Major facilitator Superfamily
IG630_RS12845	COG2902	Dehydrogenase
IG630_RS12855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS12860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG630_RS12865	COG1609	Transcriptional regulator
IG630_RS12870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG630_RS12870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG630_RS12875	COG1105	Belongs to the carbohydrate kinase PfkB family
IG630_RS12880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IG630_RS12880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IG630_RS12925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IG630_RS12935	COG1862	Preprotein translocase
IG630_RS12940	COG0343	queuine tRNA-ribosyltransferase activity
IG630_RS12945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IG630_RS12980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IG630_RS12985	COG3291	Pkd domain containing protein
IG630_RS12990	COG0405	Gamma-glutamyltransferase
IG630_RS12995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IG630_RS13005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IG630_RS13010	COG0742	ribosomal rna small subunit methyltransferase
IG630_RS13015	COG0326	Molecular chaperone. Has ATPase activity
IG630_RS13090	COG0531	amino acid
IG630_RS13105	COG0006	proline dipeptidase activity
IG630_RS13115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG630_RS13130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG630_RS13135	COG3938	Belongs to the proline racemase family
IG630_RS13145	COG0552	protein localization to endoplasmic reticulum
IG630_RS13150	COG1194	a g-specific adenine glycosylase
IG630_RS13155	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IG630_RS13160	COG0784	Response regulator, receiver
IG630_RS13160	COG4191	Histidine kinase
IG630_RS13175	COG0322	excinuclease ABC activity
IG630_RS13190	COG3040	lipid binding
IG630_RS13205	COG1960	acyl-CoA dehydrogenase activity
IG630_RS13215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IG630_RS13235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG630_RS13240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG630_RS13245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG630_RS13270	COG0438	transferase activity, transferring glycosyl groups
IG630_RS13280	COG0438	transferase activity, transferring glycosyl groups
IG630_RS13285	COG0438	transferase activity, transferring glycosyl groups
IG630_RS13335	COG0072	phenylalanine-tRNA ligase activity
IG630_RS13335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG630_RS13340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IG630_RS13355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IG630_RS13360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IG630_RS13385	COG1082	Xylose isomerase domain protein TIM barrel
IG630_RS13400	COG0366	Alpha amylase catalytic
IG630_RS13455	COG3702	type iv secretory pathway
IG630_RS13475	COG2948	multi-organism process
IG630_RS13495	COG3505	Type IV secretory pathway VirD4
IG630_RS13510	COG0556	nucleotide-excision repair
IG630_RS13595	COG4695	Portal protein
IG630_RS13640	COG3179	chitinase
IG630_RS13730	COG3275	phosphorelay sensor kinase activity
IG630_RS13735	COG1611	Belongs to the LOG family
IG630_RS13745	COG2095	MarC family integral membrane protein
IG630_RS13755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IG630_RS13790	COG1185	polyribonucleotide nucleotidyltransferase activity
IG630_RS13795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IG630_RS13800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IG630_RS13805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IG630_RS13810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IG630_RS13815	COG0195	Participates in both transcription termination and antitermination
IG630_RS13830	COG1007	ATP synthesis coupled electron transport
IG630_RS13855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG630_RS13860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IG630_RS13870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IG630_RS13875	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IG630_RS13880	COG0649	NAD binding
IG630_RS13885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG630_RS13890	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG630_RS13895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG630_RS13910	COG0149	triose-phosphate isomerase activity
IG630_RS13915	COG0300	oxidoreductase activity
IG630_RS13945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG630_RS13950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IG630_RS13955	COG0159	tryptophan synthase activity
IG630_RS13965	COG0133	tryptophan synthase activity
IG630_RS13975	COG0135	phosphoribosylanthranilate isomerase activity
IG630_RS13980	COG0101	tRNA pseudouridine synthase activity
IG630_RS14000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IG630_RS14005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG630_RS14010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IG630_RS14015	COG2890	protein-(glutamine-N5) methyltransferase activity
IG630_RS14025	COG0688	phosphatidylethanolamine metabolic process
IG630_RS14035	COG0433	COG0433 Predicted ATPase
IG630_RS14040	COG0494	nUDIX hydrolase
IG630_RS14055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG630_RS14060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG630_RS14085	COG0717	Belongs to the dCTP deaminase family
IG630_RS14090	COG0489	protein tyrosine kinase activity
IG630_RS14110	COG3590	peptidase
IG630_RS14115	COG3590	peptidase
IG630_RS14135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG630_RS14140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG630_RS14145	COG2311	Membrane
IG630_RS14150	COG1047	Peptidyl-prolyl cis-trans
IG630_RS14155	COG0791	NLP P60 protein
IG630_RS14160	COG0791	NLP P60 protein
IG630_RS14170	COG4106	trans-aconitate 2-methyltransferase activity
IG630_RS14175	COG1301	dicarboxylic acid transport
IG630_RS14180	COG1785	Belongs to the alkaline phosphatase family
IG630_RS14185	COG0037	tRNA processing
IG630_RS14190	COG1722	exodeoxyribonuclease VII activity
IG630_RS14195	COG0142	geranyltranstransferase activity
IG630_RS14200	COG4104	PAAR repeat-containing protein
IG630_RS14210	COG0312	modulator of DNA gyrase
IG630_RS14215	COG3028	Belongs to the UPF0307 family
IG630_RS14220	COG0312	modulator of DNA gyrase
IG630_RS14230	COG3164	Protein of unknown function
IG630_RS14240	COG0424	maF-like protein
IG630_RS14245	COG2968	Membrane
IG630_RS14260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IG630_RS14275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IG630_RS14290	COG0495	leucyl-tRNA aminoacylation
IG630_RS14300	COG3118	belongs to the thioredoxin family
IG630_RS14325	COG2155	Conserved Protein
IG630_RS14370	COG1132	(ABC) transporter
IG630_RS14400	COG1538	Outer membrane efflux protein
IG630_RS14405	COG0745	RESPONSE REGULATOR receiver
IG630_RS14410	COG5000	phosphorelay sensor kinase activity
IG630_RS14410	COG5002	protein histidine kinase activity
IG630_RS14415	COG0475	glutathione-regulated potassium exporter activity
IG630_RS14425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG630_RS14445	COG1187	pseudouridine synthase activity
IG630_RS14450	COG5002	protein histidine kinase activity
IG630_RS14450	COG5001	Diguanylate cyclase
IG630_RS14570	COG0667	Aldo Keto reductase
IG630_RS14580	COG2814	Major facilitator Superfamily
IG630_RS14585	COG0583	DNA-binding transcription factor activity
IG630_RS14595	COG2207	Transcriptional regulator
IG630_RS14605	COG1309	transcriptional regulator
IG630_RS14630	COG0735	belongs to the Fur family
IG630_RS14635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG630_RS14660	COG4452	Inner membrane protein CreD
IG630_RS14675	COG2205	protein histidine kinase activity
IG630_RS14680	COG0745	RESPONSE REGULATOR receiver
IG630_RS14685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IG630_RS14695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IG630_RS14725	COG0643	Histidine kinase
IG630_RS14725	COG2198	Histidine kinase
IG630_RS14730	COG0840	transmembrane signaling receptor activity
IG630_RS14735	COG0835	chemotaxis
IG630_RS14740	COG2202	Pas domain
IG630_RS14740	COG2199	diguanylate cyclase activity
IG630_RS14740	COG2200	EAL domain
IG630_RS14745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IG630_RS14750	COG2201	protein-glutamate methylesterase activity
IG630_RS14755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG630_RS14760	COG3590	peptidase
IG630_RS14770	COG0588	phosphoglycerate mutase activity
IG630_RS14775	COG1515	deoxyribonuclease V activity
IG630_RS14785	COG1741	Belongs to the pirin family
IG630_RS14800	COG1741	Belongs to the pirin family
IG630_RS14805	COG1966	Carbon starvation protein
IG630_RS14810	COG2879	small protein
IG630_RS14855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG630_RS14860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IG630_RS14865	COG2080	2 iron, 2 sulfur cluster binding
IG630_RS14880	COG3706	GGDEF domain
IG630_RS14880	COG2203	Gaf domain
IG630_RS14880	COG5001	Diguanylate cyclase
IG630_RS14880	COG4251	negative regulation of phosphorylation
IG630_RS14885	COG0629	single-stranded DNA binding
IG630_RS14890	COG0142	geranyltranstransferase activity
IG630_RS14900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IG630_RS14915	COG0527	aspartate kinase activity
IG630_RS14920	COG0384	phenazine biosynthesis protein PhzF
IG630_RS14925	COG0384	phenazine biosynthesis protein PhzF
IG630_RS14935	COG1764	response to oxidative stress
IG630_RS14940	COG0540	Belongs to the ATCase OTCase family
IG630_RS14945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IG630_RS14950	COG1678	Uncharacterized ACR, COG1678
IG630_RS14955	COG0519	Catalyzes the synthesis of GMP from XMP
IG630_RS14970	COG5297	Belongs to the glycosyl hydrolase family 6
IG630_RS14985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IG630_RS15000	COG0739	heme binding
IG630_RS15020	COG0693	protein deglycase activity
IG630_RS15030	COG1959	2 iron, 2 sulfur cluster binding
IG630_RS15035	COG0719	Fe-S assembly protein
IG630_RS15040	COG0396	ATPase activity
IG630_RS15045	COG0719	Fe-S assembly protein
IG630_RS15050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IG630_RS15060	COG2146	nitrite reductase [NAD(P)H] activity
IG630_RS15065	COG4774	siderophore transport
IG630_RS15070	COG3128	pkhd-type hydroxylase
IG630_RS15095	COG1477	protein flavinylation
IG630_RS15100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG630_RS15115	COG1555	photosystem II stabilization
IG630_RS15120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG630_RS15130	COG3178	'Phosphotransferase
IG630_RS15135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IG630_RS15145	COG0628	permease
IG630_RS15155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IG630_RS15165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IG630_RS15185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG630_RS15190	COG0271	Belongs to the BolA IbaG family
IG630_RS15200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IG630_RS15210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IG630_RS15215	COG1137	ATPase activity
IG630_RS15230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG630_RS15235	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IG630_RS15240	COG1660	Displays ATPase and GTPase activities
IG630_RS15250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG630_RS15255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG630_RS15260	COG2239	Acts as a magnesium transporter
IG630_RS15275	COG1294	oxidase, subunit
IG630_RS15280	COG1271	oxidase subunit
IG630_RS15290	COG1113	amino acid transport
IG630_RS15310	COG2197	response regulator
IG630_RS15320	COG0531	amino acid
IG630_RS15340	COG1234	tRNA 3'-trailer cleavage
IG630_RS15375	COG2814	Major facilitator Superfamily
IG630_RS15385	COG0754	glutathionylspermidine amidase activity
IG630_RS15410	COG1842	Phage shock protein A
IG630_RS15420	COG0259	pyridoxamine-phosphate oxidase activity
IG630_RS15425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG630_RS15430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IG630_RS15440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IG630_RS15515	COG2814	Major facilitator Superfamily
IG630_RS15535	COG2198	Histidine kinase
IG630_RS15535	COG0784	Response regulator, receiver
IG630_RS15535	COG2205	protein histidine kinase activity
IG630_RS15540	COG2353	YceI-like domain
IG630_RS15560	COG1760	l-serine dehydratase
IG630_RS15570	COG0527	aspartate kinase activity
IG630_RS15570	COG0460	homoserine dehydrogenase
IG630_RS15575	COG0626	cystathionine gamma-synthase activity
IG630_RS15580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG630_RS15585	COG0739	heme binding
IG630_RS15590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IG630_RS15595	COG1272	protein, Hemolysin III
IG630_RS15600	COG2982	Protein involved in outer membrane biogenesis
IG630_RS15605	COG0517	IMP dehydrogenase activity
IG630_RS15605	COG0516	GMP reductase activity
IG630_RS15610	COG0463	Glycosyl transferase, family 2
IG630_RS15615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG630_RS15620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IG630_RS15630	COG4771	TonB-dependent receptor
IG630_RS15640	COG1309	transcriptional regulator
IG630_RS15650	COG1960	acyl-CoA dehydrogenase activity
IG630_RS15680	COG0509	glycine decarboxylation via glycine cleavage system
IG630_RS15685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG630_RS15695	COG0330	HflC and HflK could
IG630_RS15700	COG1742	UPF0060 membrane protein
IG630_RS15705	COG3956	TIGRFAM MazG family protein
IG630_RS15715	COG0494	nUDIX hydrolase
IG630_RS15725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IG630_RS15730	COG0837	glucose binding
IG630_RS15745	COG1388	LysM domain
IG630_RS15745	COG3858	chitin binding
IG630_RS15750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IG630_RS15760	COG1472	Belongs to the glycosyl hydrolase 3 family
IG630_RS15775	COG0531	amino acid
IG630_RS15785	COG1486	melibiose metabolic process
IG630_RS15795	COG3537	Alpha-1,2-mannosidase
IG630_RS15830	COG3142	Participates in the control of copper homeostasis
IG630_RS15835	COG1446	asparaginase
IG630_RS15855	COG2198	Histidine kinase
IG630_RS15855	COG0784	Response regulator, receiver
IG630_RS15855	COG0643	Histidine kinase
IG630_RS15860	COG0840	transmembrane signaling receptor activity
IG630_RS15865	COG0835	chemotaxis
IG630_RS15880	COG0189	ligase activity
IG630_RS15890	COG1397	ADP-ribosylglycohydrolase
IG630_RS15900	COG1199	ATP-dependent helicase activity
IG630_RS15910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG630_RS15915	COG1215	transferase activity, transferring glycosyl groups
IG630_RS15925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG630_RS15935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IG630_RS15940	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IG630_RS15945	COG0535	radical SAM domain protein
IG630_RS15950	COG0535	radical SAM domain protein
IG630_RS15965	COG0837	glucose binding
IG630_RS15980	COG1643	Atp-dependent helicase
IG630_RS15985	COG0783	Belongs to the Dps family
IG630_RS15990	COG0514	ATP-dependent DNA helicase (RecQ)
IG630_RS16020	COG0840	transmembrane signaling receptor activity
IG630_RS16040	COG3920	Histidine kinase
IG630_RS16045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IG630_RS16055	COG0602	queuosine metabolic process
IG630_RS16065	COG2885	chlorophyll binding
IG630_RS16070	COG0823	Involved in the tonB-independent uptake of proteins
IG630_RS16080	COG0848	biopolymer transport protein
IG630_RS16090	COG0824	Thioesterase
IG630_RS16095	COG2255	four-way junction helicase activity
IG630_RS16105	COG3158	transport of potassium into the cell
IG630_RS16110	COG0632	four-way junction helicase activity
IG630_RS16115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IG630_RS16120	COG0217	transcriptional regulatory protein
IG630_RS16135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IG630_RS16150	COG0477	Major facilitator Superfamily
IG630_RS16195	COG0488	(ABC) transporter
IG630_RS16225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG630_RS16225	COG4651	solute:proton antiporter activity
IG630_RS16250	COG4772	TonB-dependent receptor
IG630_RS16260	COG4264	IucA IucC family
IG630_RS16275	COG0019	diaminopimelate decarboxylase activity
IG630_RS16300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IG630_RS16310	COG1492	cobalamin metabolic process
IG630_RS16320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IG630_RS16340	COG4206	TonB-dependent receptor
IG630_RS16345	COG0542	response to heat
IG630_RS16350	COG1116	anion transmembrane transporter activity
IG630_RS16355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG630_RS16360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG630_RS16365	COG0667	Aldo Keto reductase
IG630_RS16370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG630_RS16375	COG4771	TonB-dependent receptor
IG630_RS16380	COG2827	Endonuclease containing a URI domain
IG630_RS16420	COG1877	trehalose-phosphatase activity
IG630_RS16425	COG3387	PFAM Glycoside hydrolase 15-related
IG630_RS16440	COG0840	transmembrane signaling receptor activity
IG630_RS16445	COG3011	Protein conserved in bacteria
IG630_RS16460	COG0564	pseudouridine synthase activity
IG630_RS16465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG630_RS16475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG630_RS16475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IG630_RS16495	COG2951	lytic endotransglycosylase activity
IG630_RS16500	COG4644	lycopene metabolic process
IG630_RS16515	COG2369	cell adhesion
IG630_RS16540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IG630_RS16545	COG0045	succinate-CoA ligase (ADP-forming) activity
IG630_RS16560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IG630_RS16590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IG630_RS16595	COG0237	dephospho-CoA kinase activity
IG630_RS16620	COG5002	protein histidine kinase activity
IG630_RS16625	COG0745	RESPONSE REGULATOR receiver
IG630_RS16705	COG2003	Belongs to the UPF0758 family
IG630_RS16730	COG4191	Histidine kinase
IG630_RS16730	COG0784	Response regulator, receiver
IG630_RS16735	COG4191	Histidine kinase
IG630_RS16735	COG0784	Response regulator, receiver
IG630_RS16845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IG630_RS16875	COG2022	thiamine diphosphate biosynthetic process
IG630_RS16880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IG630_RS16885	COG0471	metal ion transport
IG630_RS16885	COG3273	potassium ion transport
IG630_RS16905	COG1970	mechanosensitive ion channel activity
IG630_RS16925	COG3250	beta-galactosidase activity
IG630_RS16930	COG4948	Mandelate Racemase Muconate Lactonizing
IG630_RS16945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG630_RS16955	COG0308	aminopeptidase N
IG630_RS16990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG630_RS17005	COG2895	sulfate adenylyltransferase (ATP) activity
IG630_RS17005	COG0529	Catalyzes the synthesis of activated sulfate
IG630_RS17010	COG0175	sulfate reduction
IG630_RS17015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG630_RS17020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG630_RS17025	COG0175	sulfate reduction
IG630_RS17045	COG2205	protein histidine kinase activity
IG630_RS17045	COG0784	Response regulator, receiver
IG630_RS17045	COG2198	Histidine kinase
IG630_RS17060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IG630_RS17060	COG1648	precorrin-2 dehydrogenase activity
IG630_RS17075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IG630_RS17080	COG3588	fructose-bisphosphate aldolase
IG630_RS17085	COG0469	pyruvate kinase activity
IG630_RS17095	COG0126	phosphoglycerate kinase activity
IG630_RS17115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IG630_RS17125	COG3047	cAMP biosynthetic process
IG630_RS17130	COG3047	cAMP biosynthetic process
IG630_RS17140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG630_RS17140	COG3453	Protein conserved in bacteria
IG630_RS17145	COG0725	ABC transporter, periplasmic molybdate-binding protein
IG630_RS17150	COG4149	molybdate abc transporter
IG630_RS17155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IG630_RS17190	COG1376	ErfK ybiS ycfS ynhG family protein
IG630_RS17195	COG0739	heme binding
IG630_RS17205	COG4773	Receptor
IG630_RS17210	COG0596	Alpha beta hydrolase
IG630_RS17215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IG630_RS17220	COG1301	dicarboxylic acid transport
IG630_RS17230	COG2304	oxidoreductase activity
IG630_RS17250	COG0714	Associated with various cellular activities
IG630_RS17285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IG630_RS17310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IG630_RS17320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG630_RS17330	COG0194	GDP metabolic process
IG630_RS17335	COG1561	YicC-like family, N-terminal region
IG630_RS17340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IG630_RS17350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IG630_RS17355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG630_RS17370	COG0006	proline dipeptidase activity
IG630_RS17380	COG0006	proline dipeptidase activity
IG630_RS17385	COG3079	Belongs to the UPF0149 family
IG630_RS17405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IG630_RS17415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IG630_RS17425	COG2912	Transglutaminase-like superfamily
IG630_RS17430	COG1773	rubredoxin
IG630_RS17435	COG0352	thiamine-phosphate diphosphorylase activity
IG630_RS17450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IG630_RS17465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG630_RS17495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IG630_RS17500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG630_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS17520	COG0671	phosphoesterase, PA-phosphatase related
IG630_RS17525	COG3781	membrane
IG630_RS17535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG630_RS17540	COG0563	adenylate kinase activity
IG630_RS17555	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IG630_RS17565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IG630_RS17585	COG3710	Transcriptional regulator
IG630_RS17590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IG630_RS17600	COG0840	transmembrane signaling receptor activity
IG630_RS17605	COG0405	Gamma-glutamyltransferase
IG630_RS17610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IG630_RS17630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG630_RS17635	COG0473	3-isopropylmalate dehydrogenase activity
IG630_RS17640	COG0066	3-isopropylmalate dehydratase activity
IG630_RS17645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IG630_RS17665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG630_RS17670	COG1538	Outer membrane efflux protein
IG630_RS17675	COG1519	Transferase
IG630_RS17680	COG1560	Kdo2-lipid A biosynthetic process
IG630_RS17705	COG0280	phosphate acetyltransferase
IG630_RS17705	COG0281	malic enzyme
IG630_RS17710	COG1301	dicarboxylic acid transport
IG630_RS17735	COG0583	DNA-binding transcription factor activity
IG630_RS17740	COG0667	Aldo Keto reductase
IG630_RS17755	COG2197	response regulator
IG630_RS17765	COG0642	Histidine kinase
IG630_RS17780	COG2851	Citrate transporter
IG630_RS17785	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS17790	COG1609	Transcriptional regulator
IG630_RS17795	COG2211	Major facilitator Superfamily
IG630_RS17820	COG1162	GTPase activity
IG630_RS17840	COG4773	Receptor
IG630_RS17845	COG0726	polysaccharide deacetylase
IG630_RS17850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IG630_RS17880	COG1307	EDD domain protein, DegV family
IG630_RS17885	COG0242	peptide deformylase activity
IG630_RS17905	COG0457	Tetratricopeptide repeat
IG630_RS17910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IG630_RS17915	COG1215	transferase activity, transferring glycosyl groups
IG630_RS17920	COG1215	transferase activity, transferring glycosyl groups
IG630_RS17935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IG630_RS17980	COG2188	Transcriptional regulator
IG630_RS17995	COG1450	Type ii and iii secretion system protein
IG630_RS18010	COG3166	PFAM Fimbrial assembly family protein
IG630_RS18015	COG3156	type II secretion system protein K
IG630_RS18020	COG4795	General secretion pathway protein
IG630_RS18025	COG2165	general secretion pathway protein
IG630_RS18030	COG4970	Tfp pilus assembly protein FimT
IG630_RS18035	COG2165	general secretion pathway protein
IG630_RS18040	COG1459	type II secretion system
IG630_RS18045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IG630_RS18050	COG1404	Belongs to the peptidase S8 family
IG630_RS18055	COG5295	Hep Hag repeat protein
IG630_RS18060	COG1404	Belongs to the peptidase S8 family
IG630_RS18065	COG5295	Hep Hag repeat protein
IG630_RS18070	COG0047	phosphoribosylformylglycinamidine synthase activity
IG630_RS18070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IG630_RS18075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IG630_RS18080	COG4974	Belongs to the 'phage' integrase family
IG630_RS18095	COG0795	lipopolysaccharide-transporting ATPase activity
IG630_RS18105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IG630_RS18120	COG0525	valine-tRNA ligase activity
IG630_RS18155	COG1183	phosphatidylcholine synthase activity
IG630_RS18165	COG0442	prolyl-tRNA aminoacylation
IG630_RS18180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IG630_RS18185	COG1127	ABC transporter
IG630_RS18190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IG630_RS18190	COG3218	ABC-type transport auxiliary lipoprotein component
IG630_RS18225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG630_RS18230	COG0662	Cupin 2, conserved barrel domain protein
IG630_RS18230	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IG630_RS18260	COG2086	electron transfer activity
IG630_RS18275	COG0546	phosphoglycolate phosphatase activity
IG630_RS18275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IG630_RS18280	COG0277	FAD linked oxidase domain protein
IG630_RS18295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG630_RS18325	COG0438	transferase activity, transferring glycosyl groups
IG630_RS18325	COG1216	Glycosyl transferase, family 2
IG630_RS18345	COG0626	cystathionine gamma-synthase activity
IG630_RS18375	COG0625	glutathione transferase activity
IG630_RS18385	COG0513	Belongs to the DEAD box helicase family
IG630_RS18395	COG4206	TonB-dependent receptor
IG630_RS18400	COG0720	synthase
IG630_RS18410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IG630_RS18415	COG1956	GAF domain-containing protein
IG630_RS18425	COG2819	hydrolase of the alpha beta superfamily
IG630_RS18440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IG630_RS18445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG630_RS18460	COG0339	signal peptide processing
IG630_RS18515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IG630_RS18520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS18525	COG4591	ABC-type transport system involved in lipoprotein release permease component
IG630_RS18525	COG1136	(ABC) transporter
IG630_RS18530	COG0577	efflux transmembrane transporter activity
IG630_RS18530	COG1136	(ABC) transporter
IG630_RS18535	COG0577	efflux transmembrane transporter activity
IG630_RS18550	COG4191	Histidine kinase
IG630_RS18555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG630_RS18570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IG630_RS18575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IG630_RS18580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IG630_RS18585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IG630_RS18590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG630_RS18595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IG630_RS18605	COG0356	it plays a direct role in the translocation of protons across the membrane
IG630_RS18625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG630_RS18635	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG630_RS18675	COG2011	ABC-type metal ion transport system permease component
IG630_RS18680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IG630_RS18685	COG0697	spore germination
IG630_RS18690	COG1666	GTP binding
IG630_RS18700	COG0784	Response regulator, receiver
IG630_RS18700	COG2198	Histidine kinase
IG630_RS18700	COG5002	protein histidine kinase activity
IG630_RS18720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG630_RS18725	COG1187	pseudouridine synthase activity
IG630_RS18730	COG2813	Specifically methylates the guanine in position
IG630_RS18750	COG2202	Pas domain
IG630_RS18750	COG2205	protein histidine kinase activity
IG630_RS18770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IG630_RS18775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG630_RS18830	COG0842	Transport permease protein
IG630_RS18835	COG1131	(ABC) transporter
IG630_RS18840	COG0025	NhaP-type Na H and K H
IG630_RS18845	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IG630_RS18850	COG1573	uracil-dna glycosylase
IG630_RS18860	COG3384	dioxygenase
IG630_RS18870	COG0583	DNA-binding transcription factor activity
IG630_RS18880	COG0667	Aldo Keto reductase
IG630_RS18910	COG0531	amino acid
IG630_RS18925	COG2972	Histidine kinase
IG630_RS18940	COG3685	Protein conserved in bacteria
IG630_RS18945	COG3546	catalase activity
IG630_RS18990	COG1271	oxidase subunit
IG630_RS18995	COG1294	oxidase, subunit
IG630_RS19010	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS19015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IG630_RS19035	COG1132	(ABC) transporter
IG630_RS19050	COG1063	alcohol dehydrogenase
IG630_RS19125	COG0251	oxidation-reduction process
IG630_RS19150	COG0840	transmembrane signaling receptor activity
IG630_RS19170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG630_RS19215	COG0024	Methionine aminopeptidase
IG630_RS19240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IG630_RS19245	COG1490	D-aminoacyl-tRNA deacylase activity
IG630_RS19250	COG1560	Kdo2-lipid A biosynthetic process
IG630_RS19300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG630_RS19300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IG630_RS19305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG630_RS19310	COG0242	peptide deformylase activity
IG630_RS19315	COG1652	LysM domain
IG630_RS19320	COG0758	DNA mediated transformation
IG630_RS19325	COG2922	Belongs to the Smg family
IG630_RS19340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IG630_RS19340	COG1754	DNA topoisomerase type I activity
IG630_RS19345	COG0009	L-threonylcarbamoyladenylate synthase
IG630_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS19370	COG0616	signal peptide processing
IG630_RS19375	COG0534	Mate efflux family protein
IG630_RS19395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IG630_RS19400	COG0625	glutathione transferase activity
IG630_RS19415	COG1252	NADH dehydrogenase
IG630_RS19420	COG2860	membrane
IG630_RS19425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IG630_RS19430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IG630_RS19435	COG2201	protein-glutamate methylesterase activity
IG630_RS19440	COG2177	Part of the ABC transporter FtsEX involved in
IG630_RS19445	COG2884	Cell division ATP-binding protein ftsE
IG630_RS19450	COG0513	Belongs to the DEAD box helicase family
IG630_RS19455	COG3118	belongs to the thioredoxin family
IG630_RS19460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IG630_RS19465	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IG630_RS19470	COG0583	DNA-binding transcription factor activity
IG630_RS19515	COG1518	maintenance of DNA repeat elements
IG630_RS19520	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IG630_RS19530	COG1652	LysM domain
IG630_RS19535	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IG630_RS19535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IG630_RS19540	COG1473	amidohydrolase
IG630_RS19545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS19550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG630_RS19560	COG5383	Protein conserved in bacteria
IG630_RS19600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IG630_RS19605	COG3023	N-Acetylmuramoyl-L-alanine amidase
IG630_RS19615	COG4948	Mandelate Racemase Muconate Lactonizing
IG630_RS19625	COG0531	amino acid
IG630_RS19640	COG4682	membrane
IG630_RS19645	COG2133	pyrroloquinoline quinone binding
IG630_RS19655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IG630_RS19660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IG630_RS19670	COG1610	YqeY-like protein
IG630_RS19675	COG1295	ribonuclease BN
IG630_RS19680	COG0358	DNA primase activity
IG630_RS19695	COG0109	protoheme IX farnesyltransferase activity
IG630_RS19725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IG630_RS19740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG630_RS19780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IG630_RS19785	COG0739	heme binding
IG630_RS19790	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IG630_RS19800	COG2223	nitrite transmembrane transporter activity
IG630_RS19805	COG0708	Exodeoxyribonuclease III
IG630_RS19810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IG630_RS19820	COG1192	Involved in chromosome partitioning
IG630_RS19825	COG1475	DNA binding
IG630_RS19840	COG0463	Glycosyl transferase, family 2
IG630_RS19860	COG0756	dUTP diphosphatase activity
IG630_RS19865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IG630_RS19870	COG2003	Belongs to the UPF0758 family
IG630_RS19875	COG0018	arginyl-trna synthetase
IG630_RS19890	COG4221	oxidoreductase activity
IG630_RS19895	COG2755	lipolytic protein G-D-S-L family
IG630_RS19895	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG630_RS19905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IG630_RS19910	COG1166	arginine decarboxylase activity
IG630_RS19915	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG630_RS19950	COG0606	chelatase, subunit chli
IG630_RS19965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IG630_RS19990	COG1690	Belongs to the RtcB family
IG630_RS20030	COG1090	epimerase
IG630_RS20040	COG0642	Histidine kinase
IG630_RS20065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG630_RS20090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG630_RS20095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IG630_RS20110	COG0753	catalase activity
IG630_RS20125	COG2197	response regulator
IG630_RS20130	COG4585	Histidine kinase
IG630_RS20135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS20140	COG1136	(ABC) transporter
IG630_RS20165	COG0697	spore germination
IG630_RS20180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG630_RS20185	COG0180	Tryptophanyl-tRNA synthetase
IG630_RS20190	COG3237	CsbD-like
IG630_RS20230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IG630_RS20245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IG630_RS20290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IG630_RS20310	COG1199	ATP-dependent helicase activity
IG630_RS20325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG630_RS20390	COG0625	glutathione transferase activity
IG630_RS20425	COG4555	ABC transporter
IG630_RS20435	COG1476	TRANSCRIPTIONal
IG630_RS20480	COG0543	2 iron, 2 sulfur cluster binding
IG630_RS20480	COG0633	Ferredoxin
IG630_RS20485	COG1131	(ABC) transporter
IG630_RS20490	COG0842	Transport permease protein
IG630_RS20500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG630_RS20535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG630_RS20540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG630_RS20550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IG630_RS20550	COG0045	succinate-CoA ligase (ADP-forming) activity
IG630_RS20550	COG1042	CoA-binding domain protein
IG630_RS20555	COG2239	Acts as a magnesium transporter
IG630_RS20570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IG630_RS20575	COG3387	PFAM Glycoside hydrolase 15-related
IG630_RS20590	COG3100	YcgL domain-containing protein
IG630_RS20595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IG630_RS20605	COG0463	Glycosyl transferase, family 2
IG630_RS20625	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS20665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG630_RS20680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG630_RS20705	COG4946	Tricorn protease homolog
IG630_RS20705	COG0823	Involved in the tonB-independent uptake of proteins
IG630_RS20705	COG1506	peptidase
IG630_RS20720	COG0408	coproporphyrinogen oxidase activity
IG630_RS20755	COG2815	serine threonine protein kinase
IG630_RS20755	COG0515	serine threonine protein kinase
IG630_RS20760	COG0631	protein serine/threonine phosphatase activity
IG630_RS20930	COG0210	DNA helicase
IG630_RS20940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG630_RS20945	COG0583	DNA-binding transcription factor activity
IG630_RS20950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG630_RS20960	COG2159	amidohydrolase
IG630_RS20980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS21000	COG0357	Ribosomal RNA small subunit methyltransferase G
IG630_RS21005	COG3540	Alkaline phosphatase
IG630_RS21015	COG2091	lysine biosynthetic process via aminoadipic acid
IG630_RS21030	COG0708	Exodeoxyribonuclease III
IG630_RS21035	COG1940	carbohydrate kinase activity
IG630_RS21035	COG1846	Transcriptional regulator
IG630_RS21045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG630_RS21055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IG630_RS21060	COG3162	membrane
IG630_RS21070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG630_RS21095	COG3507	Belongs to the glycosyl hydrolase 43 family
IG630_RS21115	COG1028	Short-chain dehydrogenase reductase Sdr
IG630_RS21120	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG630_RS21125	COG4948	Mandelate Racemase Muconate Lactonizing
IG630_RS21130	COG3254	rhamnose metabolic process
IG630_RS21135	COG0738	Major facilitator superfamily
IG630_RS21140	COG1414	Transcriptional regulator
IG630_RS21145	COG1971	Probably functions as a manganese efflux pump
IG630_RS21150	COG2205	protein histidine kinase activity
IG630_RS21160	COG3459	Glycosyltransferase 36 associated
IG630_RS21165	COG2211	Major facilitator Superfamily
IG630_RS21170	COG3265	gluconokinase activity
IG630_RS21175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG630_RS21195	COG2911	Protein conserved in bacteria
IG630_RS21200	COG0729	surface antigen
IG630_RS21240	COG0752	glycyl-tRNA synthetase alpha subunit
IG630_RS21245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IG630_RS21255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG630_RS21255	COG0519	Catalyzes the synthesis of GMP from XMP
IG630_RS21265	COG0805	protein transport
IG630_RS21270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG630_RS21275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG630_RS21285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IG630_RS21305	COG2974	May be involved in recombination
IG630_RS21310	COG0037	tRNA processing
IG630_RS21315	COG2115	Belongs to the xylose isomerase family
IG630_RS21325	COG3661	Belongs to the glycosyl hydrolase 67 family
IG630_RS21335	COG4948	Mandelate Racemase Muconate Lactonizing
IG630_RS21345	COG1472	Belongs to the glycosyl hydrolase 3 family
IG630_RS21350	COG0246	Mannitol dehydrogenase
IG630_RS21425	COG3386	PFAM SMP-30 Gluconolaconase
IG630_RS21435	COG3250	beta-galactosidase activity
IG630_RS21440	COG1904	glucuronate isomerase
IG630_RS21445	COG3693	PFAM glycoside hydrolase, family 10
IG630_RS21455	COG3693	PFAM glycoside hydrolase, family 10
IG630_RS21470	COG2211	Major facilitator Superfamily
IG630_RS21540	COG2937	Belongs to the GPAT DAPAT family
IG630_RS21570	COG0284	orotidine-5'-phosphate decarboxylase activity
IG630_RS21575	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IG630_RS21580	COG3132	Protein of unknown function, DUF480
IG630_RS21595	COG0210	DNA helicase
IG630_RS21600	COG1435	thymidine kinase activity
IG630_RS21610	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IG630_RS21620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IG630_RS21650	COG3135	benzoate transporter
IG630_RS21670	COG0676	glucose-6-phosphate 1-epimerase activity
IG630_RS21680	COG3012	SEC-C Motif Domain Protein
IG630_RS21685	COG0730	response to heat
IG630_RS21705	COG0302	gtp cyclohydrolase
IG630_RS21720	COG1566	PFAM secretion protein HlyD family protein
IG630_RS21730	COG1289	transmembrane transporter activity
IG630_RS21735	COG0477	Major facilitator Superfamily
IG630_RS21745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG630_RS21765	COG4691	Plasmid stability protein
IG630_RS21770	COG1487	ribonuclease activity
IG630_RS21805	COG0564	pseudouridine synthase activity
IG630_RS21830	COG0439	Biotin carboxylase
IG630_RS21875	COG1074	ATP-dependent DNA helicase activity
IG630_RS21880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IG630_RS21895	COG1127	ABC transporter
IG630_RS21900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IG630_RS21905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IG630_RS21920	COG2853	Lipoprotein
IG630_RS21930	COG0386	Belongs to the glutathione peroxidase family
IG630_RS21940	COG1322	Protein conserved in bacteria
IG630_RS21945	COG0604	alcohol dehydrogenase
IG630_RS21960	COG0625	glutathione transferase activity
IG630_RS21970	COG0531	amino acid
IG630_RS21975	COG3537	Alpha-1,2-mannosidase
IG630_RS21985	COG3706	GGDEF domain
IG630_RS21990	COG3835	regulator
IG630_RS21995	COG1929	Belongs to the glycerate kinase type-1 family
IG630_RS22000	COG2271	Major facilitator Superfamily
IG630_RS22015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IG630_RS22020	COG0861	Integral membrane protein TerC family
IG630_RS22030	COG0584	glycerophosphoryl diester phosphodiesterase
IG630_RS22045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IG630_RS22050	COG0726	polysaccharide deacetylase
IG630_RS22055	COG0706	membrane insertase activity
IG630_RS22060	COG0594	ribonuclease P activity
IG630_RS22110	COG2951	lytic endotransglycosylase activity
IG630_RS22115	COG4644	lycopene metabolic process
IG630_RS22255	COG2948	multi-organism process
IG630_RS22260	COG3504	Conjugal transfer protein
IG630_RS22360	COG4456	Virulence-associated protein
IG630_RS22365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG630_RS22405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG630_RS22430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG630_RS22595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG630_RS22610	COG1192	Involved in chromosome partitioning
IG630_RS22620	COG3318	Belongs to the UPF0149 family
IG630_RS22620	COG3012	SEC-C Motif Domain Protein
IG630_RS22695	COG1475	DNA binding
IG630_RS22715	COG2885	chlorophyll binding
IG630_RS22795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IG630_RS22860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG630_RS22920	COG2132	Multicopper oxidase
IG630_RS22955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS22960	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG630_RS23000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG630_RS23005	COG1393	Belongs to the ArsC family
IG630_RS23010	COG0431	NADPH-dependent FMN reductase
IG630_RS23015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IG630_RS23060	COG4644	lycopene metabolic process
IG630_RS23245	COG4232	protein-disulfide reductase activity
IG630_RS23350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IG630_RS23380	COG0629	single-stranded DNA binding
IG630_RS23415	COG1475	DNA binding
IG630_RS23460	COG1525	nuclease
IG630_RS23535	COG0745	RESPONSE REGULATOR receiver
IG630_RS23550	COG1199	ATP-dependent helicase activity
IG630_RS23725	COG1192	Involved in chromosome partitioning
IG630_RS23960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG630_RS23965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG630_RS23980	COG0010	Belongs to the arginase family