locus-tag	class	description
G4Q83_RS00020	COG1295	ribonuclease BN
G4Q83_RS00025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Q83_RS00045	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4Q83_RS00070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4Q83_RS00075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4Q83_RS00090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4Q83_RS00100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4Q83_RS00110	COG0193	aminoacyl-tRNA hydrolase activity
G4Q83_RS00115	COG0012	GTP binding
G4Q83_RS00125	COG0477	Major facilitator Superfamily
G4Q83_RS00130	COG0302	gtp cyclohydrolase
G4Q83_RS00140	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS00190	COG0676	glucose-6-phosphate 1-epimerase activity
G4Q83_RS00295	COG1858	cytochrome C peroxidase
G4Q83_RS00305	COG1166	arginine decarboxylase activity
G4Q83_RS00320	COG2960	long-chain fatty acid transporting porin activity
G4Q83_RS00325	COG0606	chelatase, subunit chli
G4Q83_RS00355	COG3039	Transposase
G4Q83_RS00365	COG4585	Histidine kinase
G4Q83_RS00395	COG3387	PFAM Glycoside hydrolase 15-related
G4Q83_RS00415	COG3100	YcgL domain-containing protein
G4Q83_RS00420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Q83_RS00430	COG0463	Glycosyl transferase, family 2
G4Q83_RS00475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4Q83_RS00480	COG0511	ligase activity, forming carbon-carbon bonds
G4Q83_RS00485	COG0439	Biotin carboxylase
G4Q83_RS00500	COG0242	peptide deformylase activity
G4Q83_RS00505	COG0488	(ABC) transporter
G4Q83_RS00510	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS00540	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS00555	COG2954	triphosphatase activity
G4Q83_RS00565	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Q83_RS00585	COG4213	ABC transporter substrate-binding protein
G4Q83_RS00595	COG4214	carbohydrate transport
G4Q83_RS00615	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Q83_RS00620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4Q83_RS00625	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4Q83_RS00645	COG1201	RNA secondary structure unwinding
G4Q83_RS00650	COG1793	dna ligase
G4Q83_RS00650	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G4Q83_RS00655	COG1793	dna ligase
G4Q83_RS00655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G4Q83_RS00660	COG1960	acyl-CoA dehydrogenase activity
G4Q83_RS00690	COG0183	Belongs to the thiolase family
G4Q83_RS00725	COG1063	alcohol dehydrogenase
G4Q83_RS00750	COG0753	catalase activity
G4Q83_RS00770	COG2814	Major facilitator Superfamily
G4Q83_RS00795	COG2197	response regulator
G4Q83_RS00815	COG2194	sulfuric ester hydrolase activity
G4Q83_RS00825	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS00830	COG2205	protein histidine kinase activity
G4Q83_RS00845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G4Q83_RS00850	COG2894	cell division
G4Q83_RS00855	COG0850	regulation of cytokinetic process
G4Q83_RS00865	COG4585	Histidine kinase
G4Q83_RS00895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G4Q83_RS00960	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G4Q83_RS01025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G4Q83_RS01035	COG1946	Acyl-CoA thioesterase
G4Q83_RS01040	COG1024	Enoyl-CoA hydratase
G4Q83_RS01040	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Q83_RS01055	COG0824	Thioesterase
G4Q83_RS01060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4Q83_RS01065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4Q83_RS01070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4Q83_RS01075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4Q83_RS01135	COG0196	riboflavin kinase activity
G4Q83_RS01150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G4Q83_RS01175	COG0750	zinc metalloprotease
G4Q83_RS01190	COG2964	Protein conserved in bacteria
G4Q83_RS01200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4Q83_RS01205	COG1845	cytochrome c oxidase, subunit III
G4Q83_RS01210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4Q83_RS01215	COG1595	DNA-templated transcription, initiation
G4Q83_RS01220	COG0740	serine-type endopeptidase activity
G4Q83_RS01310	COG4794	Type iii secretion
G4Q83_RS01335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4Q83_RS01380	COG2207	Transcriptional regulator
G4Q83_RS01405	COG0129	dihydroxy-acid dehydratase activity
G4Q83_RS01410	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS01425	COG3210	domain, Protein
G4Q83_RS01430	COG2831	hemolysin activation secretion protein
G4Q83_RS01440	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS01445	COG4771	TonB-dependent receptor
G4Q83_RS01450	COG0642	Histidine kinase
G4Q83_RS01470	COG0714	Associated with various cellular activities
G4Q83_RS01535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4Q83_RS01545	COG0586	Pfam SNARE associated Golgi protein
G4Q83_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS01565	COG0346	lactoylglutathione lyase activity
G4Q83_RS01570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Q83_RS01580	COG4206	TonB-dependent receptor
G4Q83_RS01590	COG2010	Cytochrome c
G4Q83_RS01600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4Q83_RS01605	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
G4Q83_RS01615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4Q83_RS01630	COG1773	rubredoxin
G4Q83_RS01635	COG2912	Transglutaminase-like superfamily
G4Q83_RS01655	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS01680	COG2968	Membrane
G4Q83_RS01685	COG0424	maF-like protein
G4Q83_RS01700	COG0312	modulator of DNA gyrase
G4Q83_RS01705	COG3028	Belongs to the UPF0307 family
G4Q83_RS01710	COG0312	modulator of DNA gyrase
G4Q83_RS01725	COG0142	geranyltranstransferase activity
G4Q83_RS01730	COG1722	exodeoxyribonuclease VII activity
G4Q83_RS01735	COG0037	tRNA processing
G4Q83_RS01745	COG1785	Belongs to the alkaline phosphatase family
G4Q83_RS01750	COG1301	dicarboxylic acid transport
G4Q83_RS01770	COG1607	acyl-coa hydrolase
G4Q83_RS01775	COG0791	NLP P60 protein
G4Q83_RS01780	COG0791	NLP P60 protein
G4Q83_RS01785	COG1047	Peptidyl-prolyl cis-trans
G4Q83_RS01790	COG2311	Membrane
G4Q83_RS01860	COG3590	peptidase
G4Q83_RS01880	COG4771	TonB-dependent receptor
G4Q83_RS01885	COG0489	protein tyrosine kinase activity
G4Q83_RS01890	COG0717	Belongs to the dCTP deaminase family
G4Q83_RS01910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Q83_RS01975	COG0494	nUDIX hydrolase
G4Q83_RS01980	COG0433	COG0433 Predicted ATPase
G4Q83_RS01985	COG0741	lytic transglycosylase activity
G4Q83_RS01990	COG0688	phosphatidylethanolamine metabolic process
G4Q83_RS02000	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Q83_RS02015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4Q83_RS02030	COG0101	tRNA pseudouridine synthase activity
G4Q83_RS02085	COG1959	2 iron, 2 sulfur cluster binding
G4Q83_RS02130	COG0297	glycogen (starch) synthase activity
G4Q83_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS02150	COG0149	triose-phosphate isomerase activity
G4Q83_RS02165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Q83_RS02175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Q83_RS02180	COG0649	NAD binding
G4Q83_RS02185	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G4Q83_RS02190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G4Q83_RS02195	COG1034	ATP synthesis coupled electron transport
G4Q83_RS02230	COG1007	ATP synthesis coupled electron transport
G4Q83_RS02245	COG0195	Participates in both transcription termination and antitermination
G4Q83_RS02270	COG1185	polyribonucleotide nucleotidyltransferase activity
G4Q83_RS02290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4Q83_RS02305	COG0840	transmembrane signaling receptor activity
G4Q83_RS02310	COG0835	chemotaxis
G4Q83_RS02340	COG2080	2 iron, 2 sulfur cluster binding
G4Q83_RS02345	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4Q83_RS02365	COG3214	Protein conserved in bacteria
G4Q83_RS02470	COG2226	methyltransferase
G4Q83_RS02550	COG2373	Large extracellular alpha-helical protein
G4Q83_RS02590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Q83_RS02590	COG2205	protein histidine kinase activity
G4Q83_RS02615	COG1187	pseudouridine synthase activity
G4Q83_RS02625	COG1666	GTP binding
G4Q83_RS02630	COG0697	spore germination
G4Q83_RS02640	COG2011	ABC-type metal ion transport system permease component
G4Q83_RS02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Q83_RS02680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Q83_RS02700	COG0356	it plays a direct role in the translocation of protons across the membrane
G4Q83_RS02710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4Q83_RS02715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4Q83_RS02720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4Q83_RS02730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4Q83_RS02735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4Q83_RS02755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4Q83_RS02770	COG4191	Histidine kinase
G4Q83_RS02780	COG0577	efflux transmembrane transporter activity
G4Q83_RS02780	COG1136	(ABC) transporter
G4Q83_RS02790	COG0577	efflux transmembrane transporter activity
G4Q83_RS02790	COG1136	(ABC) transporter
G4Q83_RS02800	COG1136	(ABC) transporter
G4Q83_RS02800	COG0577	efflux transmembrane transporter activity
G4Q83_RS02805	COG0577	efflux transmembrane transporter activity
G4Q83_RS02810	COG0577	efflux transmembrane transporter activity
G4Q83_RS02820	COG1136	(ABC) transporter
G4Q83_RS02830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Q83_RS02855	COG2132	Multicopper oxidase
G4Q83_RS02880	COG2217	Heavy metal translocating P-type atpase
G4Q83_RS02895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Q83_RS02905	COG4178	(ABC) transporter
G4Q83_RS02910	COG3118	belongs to the thioredoxin family
G4Q83_RS02920	COG0339	signal peptide processing
G4Q83_RS02940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4Q83_RS02945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4Q83_RS02960	COG0583	DNA-binding transcription factor activity
G4Q83_RS02965	COG0546	phosphoglycolate phosphatase activity
G4Q83_RS02970	COG4206	TonB-dependent receptor
G4Q83_RS02980	COG1956	GAF domain-containing protein
G4Q83_RS02985	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4Q83_RS02995	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS03005	COG0583	DNA-binding transcription factor activity
G4Q83_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS03050	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_RS03060	COG1162	GTPase activity
G4Q83_RS03085	COG2211	Major facilitator Superfamily
G4Q83_RS03090	COG1609	Transcriptional regulator
G4Q83_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS03100	COG2851	Citrate transporter
G4Q83_RS03115	COG0642	Histidine kinase
G4Q83_RS03130	COG2197	response regulator
G4Q83_RS03145	COG2963	transposase activity
G4Q83_RS03175	COG4191	Histidine kinase
G4Q83_RS03185	COG1301	dicarboxylic acid transport
G4Q83_RS03255	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS03280	COG1560	Kdo2-lipid A biosynthetic process
G4Q83_RS03285	COG1519	Transferase
G4Q83_RS03290	COG1538	Outer membrane efflux protein
G4Q83_RS03295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4Q83_RS03305	COG2201	protein-glutamate methylesterase activity
G4Q83_RS03320	COG3537	Alpha-1,2-mannosidase
G4Q83_RS03330	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Q83_RS03340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G4Q83_RS03345	COG3858	chitin binding
G4Q83_RS03345	COG1388	LysM domain
G4Q83_RS03370	COG0837	glucose binding
G4Q83_RS03385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4Q83_RS03395	COG0494	nUDIX hydrolase
G4Q83_RS03400	COG1218	3'(2'),5'-bisphosphate nucleotidase
G4Q83_RS03405	COG3956	TIGRFAM MazG family protein
G4Q83_RS03410	COG0330	HflC and HflK could
G4Q83_RS03475	COG2124	cytochrome p450
G4Q83_RS03480	COG2124	cytochrome p450
G4Q83_RS03485	COG1141	Ferredoxin
G4Q83_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS03495	COG2124	cytochrome p450
G4Q83_RS03500	COG0142	geranyltranstransferase activity
G4Q83_RS03510	COG1657	PFAM Prenyltransferase squalene oxidase
G4Q83_RS03520	COG1304	FMN binding
G4Q83_RS03535	COG1309	transcriptional regulator
G4Q83_RS03540	COG4206	TonB-dependent receptor
G4Q83_RS03550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G4Q83_RS03555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4Q83_RS03560	COG0463	Glycosyl transferase, family 2
G4Q83_RS03565	COG0517	IMP dehydrogenase activity
G4Q83_RS03575	COG1272	protein, Hemolysin III
G4Q83_RS03580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G4Q83_RS03590	COG1131	(ABC) transporter
G4Q83_RS03595	COG1725	Transcriptional regulator
G4Q83_RS03600	COG0739	heme binding
G4Q83_RS03605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_RS03610	COG0626	cystathionine gamma-synthase activity
G4Q83_RS03615	COG0527	aspartate kinase activity
G4Q83_RS03615	COG0460	homoserine dehydrogenase
G4Q83_RS03625	COG3706	GGDEF domain
G4Q83_RS03630	COG1760	l-serine dehydratase
G4Q83_RS03645	COG3038	cytochrome b561
G4Q83_RS03670	COG0477	Major facilitator Superfamily
G4Q83_RS03680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G4Q83_RS03690	COG4977	sequence-specific DNA binding
G4Q83_RS03695	COG1335	isochorismatase
G4Q83_RS03730	COG1842	Phage shock protein A
G4Q83_RS03755	COG5463	Belongs to the UPF0441 family
G4Q83_RS03760	COG0754	glutathionylspermidine amidase activity
G4Q83_RS03765	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS03775	COG4804	nuclease activity
G4Q83_RS03790	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS03830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G4Q83_RS03855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4Q83_RS03870	COG0495	leucyl-tRNA aminoacylation
G4Q83_RS03880	COG3118	belongs to the thioredoxin family
G4Q83_RS03895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G4Q83_RS03905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4Q83_RS03935	COG3079	Belongs to the UPF0149 family
G4Q83_RS03940	COG0006	proline dipeptidase activity
G4Q83_RS03945	COG0006	proline dipeptidase activity
G4Q83_RS04005	COG2814	Major facilitator Superfamily
G4Q83_RS04015	COG0640	Transcriptional regulator
G4Q83_RS04055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Q83_RS04065	COG1216	Glycosyl transferase, family 2
G4Q83_RS04070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4Q83_RS04080	COG1199	ATP-dependent helicase activity
G4Q83_RS04095	COG0189	ligase activity
G4Q83_RS04110	COG0835	chemotaxis
G4Q83_RS04115	COG0840	transmembrane signaling receptor activity
G4Q83_RS04120	COG0784	Response regulator, receiver
G4Q83_RS04120	COG2198	Histidine kinase
G4Q83_RS04120	COG0643	Histidine kinase
G4Q83_RS04120	COG0784	Response regulator, receiver
G4Q83_RS04120	COG0643	Histidine kinase
G4Q83_RS04120	COG2198	Histidine kinase
G4Q83_RS04125	COG2201	protein-glutamate methylesterase activity
G4Q83_RS04170	COG0583	DNA-binding transcription factor activity
G4Q83_RS04175	COG0483	inositol monophosphate 1-phosphatase activity
G4Q83_RS04185	COG0300	oxidoreductase activity
G4Q83_RS04205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4Q83_RS04215	COG4786	Flagellar basal body rod
G4Q83_RS04215	COG4786	Flagellar basal body rod
G4Q83_RS04215	COG1256	bacterial-type flagellum assembly
G4Q83_RS04215	COG1256	bacterial-type flagellum assembly
G4Q83_RS04230	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G4Q83_RS04245	COG1749	Flagellar hook protein flgE
G4Q83_RS04255	COG1558	bacterial-type flagellum-dependent cell motility
G4Q83_RS04265	COG0835	chemotaxis
G4Q83_RS04265	COG0784	Response regulator, receiver
G4Q83_RS04310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Q83_RS04315	COG1116	anion transmembrane transporter activity
G4Q83_RS04345	COG1546	Belongs to the CinA family
G4Q83_RS04350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G4Q83_RS04355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4Q83_RS04360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4Q83_RS04365	COG2137	regulation of response to DNA damage stimulus
G4Q83_RS04370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4Q83_RS04375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G4Q83_RS04405	COG0588	phosphoglycerate mutase activity
G4Q83_RS04435	COG1741	Belongs to the pirin family
G4Q83_RS04445	COG1741	Belongs to the pirin family
G4Q83_RS04450	COG1966	Carbon starvation protein
G4Q83_RS04455	COG2879	small protein
G4Q83_RS04495	COG0488	(ABC) transporter
G4Q83_RS04500	COG0513	Belongs to the DEAD box helicase family
G4Q83_RS04545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4Q83_RS04565	COG1024	Enoyl-CoA hydratase
G4Q83_RS04600	COG0505	Belongs to the CarA family
G4Q83_RS04610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4Q83_RS04615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Q83_RS04625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4Q83_RS04705	COG2963	transposase activity
G4Q83_RS04770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4Q83_RS04780	COG2198	Histidine kinase
G4Q83_RS04780	COG0784	Response regulator, receiver
G4Q83_RS04780	COG2205	protein histidine kinase activity
G4Q83_RS04785	COG1024	Enoyl-CoA hydratase
G4Q83_RS04790	COG0318	PFAM AMP-dependent synthetase and ligase
G4Q83_RS04835	COG0840	transmembrane signaling receptor activity
G4Q83_RS04845	COG0840	transmembrane signaling receptor activity
G4Q83_RS04855	COG0835	chemotaxis
G4Q83_RS04870	COG0840	transmembrane signaling receptor activity
G4Q83_RS04875	COG0840	transmembrane signaling receptor activity
G4Q83_RS04885	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS04900	COG1192	Involved in chromosome partitioning
G4Q83_RS04905	COG1360	Flagellar Motor Protein
G4Q83_RS04910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4Q83_RS04915	COG0784	Response regulator, receiver
G4Q83_RS04915	COG0643	Histidine kinase
G4Q83_RS04915	COG2198	Histidine kinase
G4Q83_RS04965	COG2267	carboxylic ester hydrolase activity
G4Q83_RS04970	COG1733	regulation of RNA biosynthetic process
G4Q83_RS04990	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS05000	COG3657	addiction module killer protein
G4Q83_RS05015	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
G4Q83_RS05020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4Q83_RS05030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Q83_RS05070	COG1136	(ABC) transporter
G4Q83_RS05070	COG0577	efflux transmembrane transporter activity
G4Q83_RS05100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4Q83_RS05100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4Q83_RS05105	COG1105	Belongs to the carbohydrate kinase PfkB family
G4Q83_RS05110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Q83_RS05110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Q83_RS05115	COG1609	Transcriptional regulator
G4Q83_RS05135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G4Q83_RS05155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4Q83_RS05255	COG0537	adenosine 5'-monophosphoramidase activity
G4Q83_RS05275	COG0714	Associated with various cellular activities
G4Q83_RS05340	COG0714	Associated with various cellular activities
G4Q83_RS05370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G4Q83_RS05400	COG1294	oxidase, subunit
G4Q83_RS05410	COG4988	ABC transporter
G4Q83_RS05415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4Q83_RS05420	COG1404	Belongs to the peptidase S8 family
G4Q83_RS05425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_RS05430	COG3385	transposase activity
G4Q83_RS05455	COG0488	(ABC) transporter
G4Q83_RS05510	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G4Q83_RS05540	COG4221	oxidoreductase activity
G4Q83_RS05580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4Q83_RS05585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G4Q83_RS05590	COG0077	Prephenate dehydratase
G4Q83_RS05590	COG1605	Chorismate mutase
G4Q83_RS05610	COG0519	Catalyzes the synthesis of GMP from XMP
G4Q83_RS05625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G4Q83_RS05650	COG1113	amino acid transport
G4Q83_RS05670	COG2239	Acts as a magnesium transporter
G4Q83_RS05675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Q83_RS05680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Q83_RS05690	COG1660	Displays ATPase and GTPase activities
G4Q83_RS05700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Q83_RS05715	COG1137	ATPase activity
G4Q83_RS05730	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G4Q83_RS05765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4Q83_RS05790	COG0628	permease
G4Q83_RS05800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4Q83_RS05805	COG3178	'Phosphotransferase
G4Q83_RS05820	COG1555	photosystem II stabilization
G4Q83_RS05880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Q83_RS05885	COG1846	Transcriptional regulator
G4Q83_RS05890	COG0339	signal peptide processing
G4Q83_RS05895	COG0386	Belongs to the glutathione peroxidase family
G4Q83_RS05935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Q83_RS05940	COG1595	DNA-templated transcription, initiation
G4Q83_RS05950	COG0625	glutathione transferase activity
G4Q83_RS05980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4Q83_RS05985	COG0084	hydrolase, TatD family'
G4Q83_RS06015	COG0305	Participates in initiation and elongation during chromosome replication
G4Q83_RS06025	COG0415	Belongs to the DNA photolyase family
G4Q83_RS06040	COG0583	DNA-binding transcription factor activity
G4Q83_RS06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_RS06075	COG3706	GGDEF domain
G4Q83_RS06130	COG2336	PFAM SpoVT AbrB
G4Q83_RS06160	COG0859	PFAM glycosyl transferase family 9
G4Q83_RS06170	COG1234	tRNA 3'-trailer cleavage
G4Q83_RS06175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4Q83_RS06180	COG0315	cyclic pyranopterin monophosphate synthase activity
G4Q83_RS06185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G4Q83_RS06190	COG0314	molybdopterin synthase activity
G4Q83_RS06215	COG0735	belongs to the Fur family
G4Q83_RS06245	COG0552	protein localization to endoplasmic reticulum
G4Q83_RS06255	COG3938	Belongs to the proline racemase family
G4Q83_RS06260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_RS06275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Q83_RS06285	COG0006	proline dipeptidase activity
G4Q83_RS06300	COG0531	amino acid
G4Q83_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_RS06375	COG1879	ABC-type sugar transport system periplasmic component
G4Q83_RS06380	COG1129	ABC transporter
G4Q83_RS06385	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_RS06390	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_RS06420	COG0475	glutathione-regulated potassium exporter activity
G4Q83_RS06455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4Q83_RS06490	COG1477	protein flavinylation
G4Q83_RS06510	COG1304	FMN binding
G4Q83_RS06515	COG4774	siderophore transport
G4Q83_RS06530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Q83_RS06535	COG0719	Fe-S assembly protein
G4Q83_RS06540	COG0396	ATPase activity
G4Q83_RS06550	COG0719	Fe-S assembly protein
G4Q83_RS06565	COG0693	protein deglycase activity
G4Q83_RS06580	COG0739	heme binding
G4Q83_RS06595	COG1764	response to oxidative stress
G4Q83_RS06605	COG0384	phenazine biosynthesis protein PhzF
G4Q83_RS06610	COG0527	aspartate kinase activity
G4Q83_RS06635	COG0142	geranyltranstransferase activity
G4Q83_RS06640	COG0629	single-stranded DNA binding
G4Q83_RS06645	COG3279	Response regulator of the LytR AlgR family
G4Q83_RS06680	COG0405	Gamma-glutamyltransferase
G4Q83_RS06685	COG4206	TonB-dependent receptor
G4Q83_RS06690	COG1297	OPT oligopeptide transporter protein
G4Q83_RS06695	COG0823	Involved in the tonB-independent uptake of proteins
G4Q83_RS06695	COG1506	peptidase
G4Q83_RS06750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4Q83_RS06765	COG1960	acyl-CoA dehydrogenase activity
G4Q83_RS06775	COG1566	PFAM secretion protein HlyD family protein
G4Q83_RS06830	COG2915	High frequency lysogenization protein hflD homolog
G4Q83_RS06835	COG0482	sulfurtransferase activity
G4Q83_RS06855	COG0542	response to heat
G4Q83_RS06885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G4Q83_RS06910	COG1674	ftsk spoiiie
G4Q83_RS06920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G4Q83_RS06930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4Q83_RS06935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4Q83_RS06970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4Q83_RS06970	COG4651	solute:proton antiporter activity
G4Q83_RS07015	COG4264	IucA IucC family
G4Q83_RS07020	COG2814	Major facilitator Superfamily
G4Q83_RS07025	COG4264	IucA IucC family
G4Q83_RS07030	COG0019	diaminopimelate decarboxylase activity
G4Q83_RS07035	COG2223	nitrite transmembrane transporter activity
G4Q83_RS07060	COG0542	response to heat
G4Q83_RS07085	COG0454	-acetyltransferase
G4Q83_RS07115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4Q83_RS07125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4Q83_RS07130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4Q83_RS07185	COG2211	Major facilitator Superfamily
G4Q83_RS07215	COG0835	chemotaxis
G4Q83_RS07220	COG0840	transmembrane signaling receptor activity
G4Q83_RS07230	COG0643	Histidine kinase
G4Q83_RS07230	COG2198	Histidine kinase
G4Q83_RS07245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4Q83_RS07260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G4Q83_RS07275	COG0642	Histidine kinase
G4Q83_RS07280	COG3111	PFAM Bacterial OB fold (BOF) protein
G4Q83_RS07335	COG3702	type iv secretory pathway
G4Q83_RS07365	COG3267	Type II secretory pathway component ExeA
G4Q83_RS07365	COG3409	Peptidoglycan-binding domain 1 protein
G4Q83_RS07385	COG3409	Peptidoglycan-binding domain 1 protein
G4Q83_RS07385	COG3773	Cell wall hydrolase
G4Q83_RS07425	COG2925	Exonuclease
G4Q83_RS07435	COG3844	kynureninase activity
G4Q83_RS07450	COG0288	reversible hydration of carbon dioxide
G4Q83_RS07480	COG0017	Asparaginyl-tRNA synthetase
G4Q83_RS07485	COG0316	Belongs to the HesB IscA family
G4Q83_RS07490	COG2977	Belongs to the P-Pant transferase superfamily
G4Q83_RS07500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4Q83_RS07515	COG3115	cell septum assembly
G4Q83_RS07525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Q83_RS07570	COG0124	histidyl-tRNA synthetase
G4Q83_RS07580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4Q83_RS07585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4Q83_RS07600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4Q83_RS07615	COG0140	phosphoribosyl-ATP diphosphatase activity
G4Q83_RS07615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4Q83_RS07635	COG5265	(ABC) transporter
G4Q83_RS07660	COG1131	(ABC) transporter
G4Q83_RS07705	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
G4Q83_RS07710	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G4Q83_RS07720	COG0531	amino acid
G4Q83_RS07725	COG0531	amino acid
G4Q83_RS07740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Q83_RS07745	COG0277	FAD linked oxidase domain protein
G4Q83_RS07755	COG1914	H( )-stimulated, divalent metal cation uptake system
G4Q83_RS07760	COG1321	iron dependent repressor
G4Q83_RS07770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G4Q83_RS07775	COG0668	transmembrane transport
G4Q83_RS07785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G4Q83_RS07800	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS07805	COG1183	phosphatidylcholine synthase activity
G4Q83_RS07815	COG3243	poly(R)-hydroxyalkanoic acid synthase
G4Q83_RS07835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G4Q83_RS07835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_RS07845	COG2183	response to ionizing radiation
G4Q83_RS07890	COG1002	Type II restriction enzyme, methylase subunits
G4Q83_RS07920	COG0583	DNA-binding transcription factor activity
G4Q83_RS07935	COG1070	Carbohydrate kinase
G4Q83_RS07940	COG2115	Belongs to the xylose isomerase family
G4Q83_RS07945	COG0477	Major facilitator Superfamily
G4Q83_RS07965	COG0617	tRNA 3'-terminal CCA addition
G4Q83_RS07970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4Q83_RS07975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4Q83_RS07990	COG0166	Belongs to the GPI family
G4Q83_RS08010	COG0840	transmembrane signaling receptor activity
G4Q83_RS08025	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G4Q83_RS08040	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_RS08115	COG0475	glutathione-regulated potassium exporter activity
G4Q83_RS08115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4Q83_RS08125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4Q83_RS08135	COG0746	molybdenum cofactor guanylyltransferase activity
G4Q83_RS08145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_RS08150	COG2976	Protein conserved in bacteria
G4Q83_RS08155	COG1426	Protein conserved in bacteria
G4Q83_RS08165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4Q83_RS08180	COG1024	Enoyl-CoA hydratase
G4Q83_RS08180	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Q83_RS08185	COG0183	Belongs to the thiolase family
G4Q83_RS08190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4Q83_RS08200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4Q83_RS08205	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G4Q83_RS08215	COG0776	regulation of translation
G4Q83_RS08220	COG0539	negative regulation of cytoplasmic translation
G4Q83_RS08225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4Q83_RS08230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4Q83_RS08240	COG2957	Belongs to the agmatine deiminase family
G4Q83_RS08245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Q83_RS08270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_RS08310	COG0316	Belongs to the HesB IscA family
G4Q83_RS08310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G4Q83_RS08325	COG0428	transporter
G4Q83_RS08330	COG3064	Membrane
G4Q83_RS08340	COG1530	ribonuclease E activity
G4Q83_RS08355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4Q83_RS08380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Q83_RS08395	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Q83_RS08395	COG1024	Enoyl-CoA hydratase
G4Q83_RS08400	COG3706	GGDEF domain
G4Q83_RS08455	COG1643	Atp-dependent helicase
G4Q83_RS08460	COG0783	Belongs to the Dps family
G4Q83_RS08475	COG0514	ATP-dependent DNA helicase (RecQ)
G4Q83_RS08535	COG1196	nuclear chromosome segregation
G4Q83_RS08630	COG3179	chitinase
G4Q83_RS08635	COG3657	addiction module killer protein
G4Q83_RS08805	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G4Q83_RS08810	COG0602	queuosine metabolic process
G4Q83_RS08820	COG2885	chlorophyll binding
G4Q83_RS08835	COG0848	biopolymer transport protein
G4Q83_RS08845	COG0824	Thioesterase
G4Q83_RS08855	COG3158	transport of potassium into the cell
G4Q83_RS08860	COG0632	four-way junction helicase activity
G4Q83_RS08870	COG0217	transcriptional regulatory protein
G4Q83_RS08885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_RS08900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G4Q83_RS08935	COG0488	(ABC) transporter
G4Q83_RS08985	COG0372	Belongs to the citrate synthase family
G4Q83_RS08995	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS09025	COG2086	electron transfer activity
G4Q83_RS09040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4Q83_RS09040	COG0546	phosphoglycolate phosphatase activity
G4Q83_RS09045	COG0277	FAD linked oxidase domain protein
G4Q83_RS09050	COG0300	oxidoreductase activity
G4Q83_RS09060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Q83_RS09090	COG3754	Rhamnan synthesis protein F
G4Q83_RS09095	COG1216	Glycosyl transferase, family 2
G4Q83_RS09095	COG0438	transferase activity, transferring glycosyl groups
G4Q83_RS09115	COG0626	cystathionine gamma-synthase activity
G4Q83_RS09145	COG0625	glutathione transferase activity
G4Q83_RS09155	COG0513	Belongs to the DEAD box helicase family
G4Q83_RS09160	COG0720	synthase
G4Q83_RS09260	COG2197	response regulator
G4Q83_RS09265	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G4Q83_RS09270	COG2201	protein-glutamate methylesterase activity
G4Q83_RS09290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Q83_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS09300	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS09360	COG1677	Flagellar hook-basal body complex protein FliE
G4Q83_RS09370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4Q83_RS09410	COG3190	flagellar
G4Q83_RS09425	COG1684	flagellar biosynthetic protein fliR
G4Q83_RS09440	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS09495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G4Q83_RS09505	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G4Q83_RS09510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4Q83_RS09525	COG0460	homoserine dehydrogenase
G4Q83_RS09525	COG0527	aspartate kinase activity
G4Q83_RS09580	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_RS09600	COG0167	dihydroorotate dehydrogenase activity
G4Q83_RS09605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4Q83_RS09620	COG2205	protein histidine kinase activity
G4Q83_RS09645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4Q83_RS09650	COG5002	protein histidine kinase activity
G4Q83_RS09655	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS09660	COG4774	siderophore transport
G4Q83_RS09665	COG0174	glutamine synthetase
G4Q83_RS09675	COG0174	glutamine synthetase
G4Q83_RS09680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_RS09690	COG0477	Major facilitator Superfamily
G4Q83_RS09710	COG2223	nitrite transmembrane transporter activity
G4Q83_RS09730	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_RS09735	COG1917	Cupin 2, conserved barrel domain protein
G4Q83_RS09735	COG1396	sequence-specific DNA binding
G4Q83_RS09740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4Q83_RS09750	COG2733	membrane
G4Q83_RS09770	COG0582	viral genome integration into host DNA
G4Q83_RS09845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G4Q83_RS09850	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS09855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4Q83_RS09860	COG0534	Mate efflux family protein
G4Q83_RS09865	COG0335	large ribosomal subunit rRNA binding
G4Q83_RS09875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4Q83_RS09890	COG2070	2-Nitropropane dioxygenase
G4Q83_RS09915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4Q83_RS09930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4Q83_RS09985	COG0351	phosphomethylpyrimidine kinase
G4Q83_RS10000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G4Q83_RS10005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4Q83_RS10015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Q83_RS10105	COG3275	phosphorelay sensor kinase activity
G4Q83_RS10110	COG1611	Belongs to the LOG family
G4Q83_RS10120	COG2095	MarC family integral membrane protein
G4Q83_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS10130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4Q83_RS10170	COG2969	positive regulation of protein catabolic process
G4Q83_RS10175	COG0625	glutathione transferase activity
G4Q83_RS10180	COG2857	Cytochrome c1
G4Q83_RS10185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4Q83_RS10190	COG0723	plastoquinol--plastocyanin reductase activity
G4Q83_RS10195	COG0741	lytic transglycosylase activity
G4Q83_RS10225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Q83_RS10235	COG1702	phosphate starvation-inducible protein PhoH
G4Q83_RS10260	COG4535	Mg2 and Co2 transporter CorC
G4Q83_RS10275	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_RS10280	COG1177	transmembrane transport
G4Q83_RS10285	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4Q83_RS10290	COG3842	ATPase activity
G4Q83_RS10310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4Q83_RS10330	COG2902	Dehydrogenase
G4Q83_RS10340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_RS10345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Q83_RS10350	COG1960	acyl-CoA dehydrogenase activity
G4Q83_RS10355	COG2226	methyltransferase
G4Q83_RS10360	COG0646	methionine synthase
G4Q83_RS10360	COG1410	methionine synthase
G4Q83_RS10365	COG1410	methionine synthase
G4Q83_RS10365	COG0646	methionine synthase
G4Q83_RS10380	COG2755	lipolytic protein G-D-S-L family
G4Q83_RS10380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G4Q83_RS10390	COG2900	Belongs to the SlyX family
G4Q83_RS10405	COG0386	Belongs to the glutathione peroxidase family
G4Q83_RS10415	COG1725	Transcriptional regulator
G4Q83_RS10420	COG1131	(ABC) transporter
G4Q83_RS10455	COG2850	peptidyl-arginine hydroxylation
G4Q83_RS10495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4Q83_RS10520	COG0800	Aldolase
G4Q83_RS10535	COG3734	2-keto-3-deoxy-galactonokinase
G4Q83_RS10540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G4Q83_RS10570	COG0556	nucleotide-excision repair
G4Q83_RS10650	COG0471	metal ion transport
G4Q83_RS10650	COG3273	potassium ion transport
G4Q83_RS10665	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Q83_RS10685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Q83_RS10705	COG0438	transferase activity, transferring glycosyl groups
G4Q83_RS10715	COG0529	Catalyzes the synthesis of activated sulfate
G4Q83_RS10715	COG2895	sulfate adenylyltransferase (ATP) activity
G4Q83_RS10725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4Q83_RS10730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Q83_RS10735	COG0175	sulfate reduction
G4Q83_RS10790	COG3588	fructose-bisphosphate aldolase
G4Q83_RS10815	COG0725	ABC transporter, periplasmic molybdate-binding protein
G4Q83_RS10820	COG4149	molybdate abc transporter
G4Q83_RS10825	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G4Q83_RS10850	COG0427	acetyl-CoA hydrolase
G4Q83_RS10865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4Q83_RS10870	COG1301	dicarboxylic acid transport
G4Q83_RS10940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4Q83_RS10970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4Q83_RS10975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4Q83_RS10980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4Q83_RS11000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4Q83_RS11005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Q83_RS11010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G4Q83_RS11015	COG1399	metal-binding, possibly nucleic acid-binding protein
G4Q83_RS11050	COG0254	rRNA binding
G4Q83_RS11060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4Q83_RS11070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Q83_RS11075	COG1758	RNA polymerase activity
G4Q83_RS11125	COG0625	glutathione transferase activity
G4Q83_RS11140	COG4681	YaeQ
G4Q83_RS11145	COG2081	HI0933 family
G4Q83_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS11200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4Q83_RS11205	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4Q83_RS11210	COG0802	atpase or kinase
G4Q83_RS11215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4Q83_RS11215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4Q83_RS11220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4Q83_RS11235	COG3040	lipid binding
G4Q83_RS11245	COG2161	toxin-antitoxin pair type II binding
G4Q83_RS11250	COG4115	mRNA cleavage
G4Q83_RS11260	COG5001	Diguanylate cyclase
G4Q83_RS11265	COG1595	DNA-templated transcription, initiation
G4Q83_RS11280	COG1132	(ABC) transporter
G4Q83_RS11290	COG1605	Chorismate mutase
G4Q83_RS11290	COG0287	Prephenate dehydrogenase
G4Q83_RS11295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G4Q83_RS11300	COG0484	heat shock protein binding
G4Q83_RS11305	COG0443	Heat shock 70 kDa protein
G4Q83_RS11310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4Q83_RS11315	COG1420	regulation of RNA biosynthetic process
G4Q83_RS11320	COG0497	DNA recombination
G4Q83_RS11325	COG0735	belongs to the Fur family
G4Q83_RS11330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_RS11340	COG2867	negative regulation of translational initiation
G4Q83_RS11345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4Q83_RS11350	COG3385	transposase activity
G4Q83_RS11390	COG2197	response regulator
G4Q83_RS11440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Q83_RS11485	COG4790	Type iii secretion
G4Q83_RS11530	COG2207	Transcriptional regulator
G4Q83_RS11580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Q83_RS11590	COG1534	Rna-binding protein
G4Q83_RS11615	COG1238	metal cluster binding
G4Q83_RS11620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4Q83_RS11625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G4Q83_RS11630	COG2840	Smr protein MutS2
G4Q83_RS11640	COG0585	pseudouridine synthase activity
G4Q83_RS11645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G4Q83_RS11650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4Q83_RS11665	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G4Q83_RS11670	COG0504	CTP synthase activity
G4Q83_RS11685	COG1879	ABC-type sugar transport system periplasmic component
G4Q83_RS11705	COG0840	transmembrane signaling receptor activity
G4Q83_RS11725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4Q83_RS11760	COG2878	Part of a membrane complex involved in electron transport
G4Q83_RS11775	COG1595	DNA-templated transcription, initiation
G4Q83_RS11790	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G4Q83_RS11800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Q83_RS11820	COG0251	oxidation-reduction process
G4Q83_RS11830	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G4Q83_RS11830	COG0392	lysyltransferase activity
G4Q83_RS11865	COG2814	Major facilitator Superfamily
G4Q83_RS11870	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_RS11880	COG2824	Alkylphosphonate utilization operon protein PhnA
G4Q83_RS11930	COG0443	Heat shock 70 kDa protein
G4Q83_RS11950	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4Q83_RS11970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4Q83_RS12010	COG5487	UPF0391 membrane protein
G4Q83_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS12160	COG3142	Participates in the control of copper homeostasis
G4Q83_RS12165	COG1446	asparaginase
G4Q83_RS12175	COG1561	YicC-like family, N-terminal region
G4Q83_RS12180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G4Q83_RS12185	COG0346	lactoylglutathione lyase activity
G4Q83_RS12200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4Q83_RS12250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4Q83_RS12265	COG0165	Argininosuccinate lyase
G4Q83_RS12280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4Q83_RS12285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Q83_RS12295	COG0137	argininosuccinate synthase activity
G4Q83_RS12300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4Q83_RS12315	COG2166	iron-sulfur cluster assembly
G4Q83_RS12370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Q83_RS12385	COG4303	Ethanolamine ammonia lyase large subunit
G4Q83_RS12390	COG4302	ethanolamine ammonia-lyase activity
G4Q83_RS12405	COG5434	Belongs to the glycosyl hydrolase 28 family
G4Q83_RS12425	COG0402	S-adenosylhomocysteine deaminase activity
G4Q83_RS12440	COG1509	lysine 2,3-aminomutase activity
G4Q83_RS12470	COG0583	DNA-binding transcription factor activity
G4Q83_RS12490	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_RS12505	COG2211	Major facilitator Superfamily
G4Q83_RS12520	COG1862	Preprotein translocase
G4Q83_RS12540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Q83_RS12545	COG1309	transcriptional regulator
G4Q83_RS12555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4Q83_RS12570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Q83_RS12575	COG0405	Gamma-glutamyltransferase
G4Q83_RS12580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4Q83_RS12600	COG0742	ribosomal rna small subunit methyltransferase
G4Q83_RS12605	COG0326	Molecular chaperone. Has ATPase activity
G4Q83_RS12650	COG2072	flavoprotein involved in K transport
G4Q83_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS12675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4Q83_RS12695	COG0306	phosphate transporter
G4Q83_RS12705	COG1253	flavin adenine dinucleotide binding
G4Q83_RS12715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Q83_RS12765	COG1663	tetraacyldisaccharide 4'-kinase activity
G4Q83_RS12770	COG1132	(ABC) transporter
G4Q83_RS12780	COG0811	peptide transport
G4Q83_RS12800	COG4591	ABC-type transport system involved in lipoprotein release permease component
G4Q83_RS12815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4Q83_RS12825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G4Q83_RS12830	COG2009	succinate dehydrogenase
G4Q83_RS12840	COG0354	folic acid binding
G4Q83_RS12850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4Q83_RS12865	COG0129	dihydroxy-acid dehydratase activity
G4Q83_RS12870	COG0800	Aldolase
G4Q83_RS12880	COG0395	ABC-type sugar transport system, permease component
G4Q83_RS12915	COG2350	Protein conserved in bacteria
G4Q83_RS12920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G4Q83_RS12925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4Q83_RS12930	COG1187	pseudouridine synthase activity
G4Q83_RS12955	COG0436	Aminotransferase
G4Q83_RS12960	COG4133	protoheme IX ABC transporter activity
G4Q83_RS13025	COG1024	Enoyl-CoA hydratase
G4Q83_RS13035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4Q83_RS13045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Q83_RS13050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Q83_RS13055	COG0573	inorganic phosphate transmembrane transporter activity
G4Q83_RS13060	COG0581	inorganic phosphate transmembrane transporter activity
G4Q83_RS13070	COG0704	Plays a role in the regulation of phosphate uptake
G4Q83_RS13095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4Q83_RS13125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Q83_RS13135	COG0557	exoribonuclease II activity
G4Q83_RS13200	COG2197	response regulator
G4Q83_RS13215	COG2814	Major facilitator Superfamily
G4Q83_RS13220	COG1566	PFAM secretion protein HlyD family protein
G4Q83_RS13255	COG0367	asparagine synthase
G4Q83_RS13260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Q83_RS13265	COG1393	Belongs to the ArsC family
G4Q83_RS13280	COG0024	Methionine aminopeptidase
G4Q83_RS13315	COG0052	Belongs to the universal ribosomal protein uS2 family
G4Q83_RS13335	COG0528	UMP kinase activity
G4Q83_RS13355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4Q83_RS13360	COG0575	Belongs to the CDS family
G4Q83_RS13365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4Q83_RS13370	COG0750	zinc metalloprotease
G4Q83_RS13375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_RS13390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4Q83_RS13410	COG0825	malonyl-CoA metabolic process
G4Q83_RS13415	COG1981	membrane
G4Q83_RS13485	COG1132	(ABC) transporter
G4Q83_RS13540	COG1187	pseudouridine synthase activity
G4Q83_RS13570	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS13660	COG3039	Transposase
G4Q83_RS13675	COG1196	nuclear chromosome segregation
G4Q83_RS13690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G4Q83_RS13700	COG0494	nUDIX hydrolase
G4Q83_RS13720	COG0653	protein targeting
G4Q83_RS13725	COG0739	heme binding
G4Q83_RS13750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4Q83_RS13755	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4Q83_RS13780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4Q83_RS13795	COG3116	cell division
G4Q83_RS13800	COG0275	rRNA processing
G4Q83_RS13805	COG2001	Belongs to the MraZ family
G4Q83_RS13855	COG0792	nuclease activity
G4Q83_RS13860	COG0277	FAD linked oxidase domain protein
G4Q83_RS13870	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS13875	COG2205	protein histidine kinase activity
G4Q83_RS13885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G4Q83_RS13890	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G4Q83_RS13910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G4Q83_RS13915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4Q83_RS13920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G4Q83_RS13935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4Q83_RS13935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4Q83_RS13985	COG1877	trehalose-phosphatase activity
G4Q83_RS13990	COG3387	PFAM Glycoside hydrolase 15-related
G4Q83_RS14020	COG0564	pseudouridine synthase activity
G4Q83_RS14025	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_RS14035	COG1125	glycine betaine transport
G4Q83_RS14040	COG1174	glycine betaine transport
G4Q83_RS14050	COG1450	Type ii and iii secretion system protein
G4Q83_RS14065	COG3166	PFAM Fimbrial assembly family protein
G4Q83_RS14070	COG3156	type II secretion system protein K
G4Q83_RS14075	COG4795	General secretion pathway protein
G4Q83_RS14080	COG2165	general secretion pathway protein
G4Q83_RS14085	COG4970	Tfp pilus assembly protein FimT
G4Q83_RS14090	COG2165	general secretion pathway protein
G4Q83_RS14095	COG1459	type II secretion system
G4Q83_RS14100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4Q83_RS14105	COG0047	phosphoribosylformylglycinamidine synthase activity
G4Q83_RS14105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4Q83_RS14110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4Q83_RS14115	COG4974	Belongs to the 'phage' integrase family
G4Q83_RS14135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4Q83_RS14140	COG2927	DNA polymerase III (CHI subunit)
G4Q83_RS14170	COG2175	clavaminate synthase activity
G4Q83_RS14190	COG0456	acetyltransferase
G4Q83_RS14210	COG1183	phosphatidylcholine synthase activity
G4Q83_RS14220	COG0442	prolyl-tRNA aminoacylation
G4Q83_RS14235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4Q83_RS14240	COG1127	ABC transporter
G4Q83_RS14245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4Q83_RS14245	COG3218	ABC-type transport auxiliary lipoprotein component
G4Q83_RS14285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Q83_RS14295	COG0328	RNA-DNA hybrid ribonuclease activity
G4Q83_RS14300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4Q83_RS14305	COG0631	protein serine/threonine phosphatase activity
G4Q83_RS14330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Q83_RS14370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4Q83_RS14410	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4Q83_RS14450	COG0473	3-isopropylmalate dehydrogenase activity
G4Q83_RS14465	COG4783	chaperone-mediated protein folding
G4Q83_RS14470	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS14480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4Q83_RS14485	COG0248	Ppx GppA phosphatase
G4Q83_RS14490	COG0438	transferase activity, transferring glycosyl groups
G4Q83_RS14500	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4Q83_RS14515	COG2833	Protein of unknown function (DUF455)
G4Q83_RS14535	COG0285	dihydrofolate synthase activity
G4Q83_RS14540	COG0588	phosphoglycerate mutase activity
G4Q83_RS14570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G4Q83_RS14575	COG4208	sulfate ABC transporter
G4Q83_RS14580	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G4Q83_RS14585	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G4Q83_RS14590	COG0156	8-amino-7-oxononanoate synthase activity
G4Q83_RS14595	COG1187	pseudouridine synthase activity
G4Q83_RS14605	COG2885	chlorophyll binding
G4Q83_RS14610	COG0583	DNA-binding transcription factor activity
G4Q83_RS14615	COG2814	Major facilitator Superfamily
G4Q83_RS14625	COG0667	Aldo Keto reductase
G4Q83_RS14635	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4Q83_RS14635	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_RS14670	COG0625	glutathione transferase activity
G4Q83_RS14685	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4Q83_RS14705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4Q83_RS14710	COG1217	gtp-binding protein TYPA
G4Q83_RS14725	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G4Q83_RS14735	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G4Q83_RS14740	COG0203	ribosomal protein L17
G4Q83_RS14750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G4Q83_RS14765	COG0201	protein transport
G4Q83_RS14775	COG1841	ribosomal large subunit assembly
G4Q83_RS14785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4Q83_RS14800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4Q83_RS14805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4Q83_RS14810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4Q83_RS14820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G4Q83_RS14825	COG0255	Belongs to the universal ribosomal protein uL29 family
G4Q83_RS14840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G4Q83_RS14850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4Q83_RS14855	COG0089	rRNA binding
G4Q83_RS14860	COG0088	Forms part of the polypeptide exit tunnel
G4Q83_RS14870	COG0051	transcription antitermination factor activity, RNA binding
G4Q83_RS14875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Q83_RS14880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4Q83_RS14895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4Q83_RS14905	COG0222	ribosome binding
G4Q83_RS14925	COG0250	Participates in transcription elongation, termination and antitermination
G4Q83_RS14940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Q83_RS14960	COG0469	pyruvate kinase activity
G4Q83_RS15010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4Q83_RS15015	COG3047	cAMP biosynthetic process
G4Q83_RS15045	COG0625	glutathione transferase activity
G4Q83_RS15100	COG4555	ABC transporter
G4Q83_RS15110	COG1476	TRANSCRIPTIONal
G4Q83_RS15120	COG0633	Ferredoxin
G4Q83_RS15120	COG0543	2 iron, 2 sulfur cluster binding
G4Q83_RS15125	COG1131	(ABC) transporter
G4Q83_RS15130	COG0842	Transport permease protein
G4Q83_RS15135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4Q83_RS15135	COG1648	precorrin-2 dehydrogenase activity
G4Q83_RS15230	COG2353	YceI-like domain
G4Q83_RS15260	COG0584	glycerophosphoryl diester phosphodiesterase
G4Q83_RS15285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G4Q83_RS15360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Q83_RS15365	COG1960	acyl-CoA dehydrogenase activity
G4Q83_RS15375	COG3245	cytochrome
G4Q83_RS15390	COG0523	cobalamin synthesis protein
G4Q83_RS15405	COG1196	nuclear chromosome segregation
G4Q83_RS15405	COG3264	Mechanosensitive ion channel
G4Q83_RS15410	COG3321	synthase
G4Q83_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS15410	COG0604	alcohol dehydrogenase
G4Q83_RS15420	COG1802	Transcriptional regulator
G4Q83_RS15435	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
G4Q83_RS15480	COG1414	Transcriptional regulator
G4Q83_RS15485	COG0738	Major facilitator superfamily
G4Q83_RS15490	COG3254	rhamnose metabolic process
G4Q83_RS15505	COG0793	Belongs to the peptidase S41A family
G4Q83_RS15510	COG4942	peptidase
G4Q83_RS15520	COG2234	aminopeptidase activity
G4Q83_RS15565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Q83_RS15565	COG0519	Catalyzes the synthesis of GMP from XMP
G4Q83_RS15570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4Q83_RS15590	COG0210	DNA helicase
G4Q83_RS15595	COG1435	thymidine kinase activity
G4Q83_RS15600	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G4Q83_RS15610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4Q83_RS15625	COG2186	Transcriptional regulator
G4Q83_RS15630	COG1304	FMN binding
G4Q83_RS15635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Q83_RS15640	COG0697	spore germination
G4Q83_RS15680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G4Q83_RS15690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G4Q83_RS15705	COG3385	transposase activity
G4Q83_RS15715	COG0840	transmembrane signaling receptor activity
G4Q83_RS15740	COG0308	aminopeptidase N
G4Q83_RS15745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4Q83_RS15755	COG2226	methyltransferase
G4Q83_RS15775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G4Q83_RS15805	COG2832	Protein of unknown function (DUF454)
G4Q83_RS15815	COG0436	Aminotransferase
G4Q83_RS15830	COG1505	serine-type exopeptidase activity
G4Q83_RS15860	COG0181	hydroxymethylbilane synthase activity
G4Q83_RS15900	COG2963	transposase activity
G4Q83_RS15990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Q83_RS15995	COG1490	D-aminoacyl-tRNA deacylase activity
G4Q83_RS16000	COG1560	Kdo2-lipid A biosynthetic process
G4Q83_RS16010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Q83_RS16020	COG1324	tolerance protein
G4Q83_RS16025	COG2356	endonuclease I
G4Q83_RS16035	COG0459	protein refolding
G4Q83_RS16045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4Q83_RS16055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Q83_RS16085	COG2267	carboxylic ester hydrolase activity
G4Q83_RS16115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Q83_RS16120	COG1077	Cell shape determining protein MreB Mrl
G4Q83_RS16125	COG1792	Involved in formation and maintenance of cell shape
G4Q83_RS16135	COG0768	penicillin binding
G4Q83_RS16140	COG0772	Belongs to the SEDS family
G4Q83_RS16165	COG2951	lytic endotransglycosylase activity
G4Q83_RS16170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4Q83_RS16175	COG1686	Belongs to the peptidase S11 family
G4Q83_RS16195	COG2921	Belongs to the UPF0250 family
G4Q83_RS16205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4Q83_RS16255	COG0667	Aldo Keto reductase
G4Q83_RS16260	COG0667	Aldo Keto reductase
G4Q83_RS16275	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS16290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G4Q83_RS16300	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G4Q83_RS16315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G4Q83_RS16320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Q83_RS16335	COG0463	Glycosyl transferase, family 2
G4Q83_RS16350	COG1475	DNA binding
G4Q83_RS16355	COG1192	Involved in chromosome partitioning
G4Q83_RS16360	COG0357	Ribosomal RNA small subunit methyltransferase G
G4Q83_RS16365	COG2091	lysine biosynthetic process via aminoadipic acid
G4Q83_RS16430	COG1971	Probably functions as a manganese efflux pump
G4Q83_RS16445	COG2205	protein histidine kinase activity
G4Q83_RS16450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Q83_RS16475	COG2937	Belongs to the GPAT DAPAT family
G4Q83_RS16480	COG2937	Belongs to the GPAT DAPAT family
G4Q83_RS16515	COG0284	orotidine-5'-phosphate decarboxylase activity
G4Q83_RS16520	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G4Q83_RS16525	COG3265	gluconokinase activity
G4Q83_RS16565	COG0840	transmembrane signaling receptor activity
G4Q83_RS16575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G4Q83_RS16585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4Q83_RS16595	COG0805	protein transport
G4Q83_RS16610	COG3384	dioxygenase
G4Q83_RS16655	COG0473	3-isopropylmalate dehydrogenase activity
G4Q83_RS16660	COG0066	3-isopropylmalate dehydratase activity
G4Q83_RS16675	COG4106	trans-aconitate 2-methyltransferase activity
G4Q83_RS16680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Q83_RS16700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4Q83_RS16730	COG3568	Endonuclease Exonuclease Phosphatase
G4Q83_RS16735	COG0392	lysyltransferase activity
G4Q83_RS16780	COG1940	carbohydrate kinase activity
G4Q83_RS16825	COG1597	lipid kinase activity
G4Q83_RS16845	COG0484	heat shock protein binding
G4Q83_RS16870	COG2111	Na H antiporter
G4Q83_RS16870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4Q83_RS16875	COG1006	Multisubunit Na H antiporter MnhC subunit
G4Q83_RS16880	COG0651	ATP synthesis coupled electron transport
G4Q83_RS16890	COG2212	antiporter activity
G4Q83_RS16895	COG1320	monovalent cation:proton antiporter activity
G4Q83_RS16935	COG3104	oligopeptide transport
G4Q83_RS16940	COG3483	tryptophan 2,3-dioxygenase activity
G4Q83_RS16980	COG4191	Histidine kinase
G4Q83_RS16985	COG0784	Response regulator, receiver
G4Q83_RS16990	COG2202	Pas domain
G4Q83_RS16990	COG2205	protein histidine kinase activity
G4Q83_RS17000	COG2823	Periplasmic or secreted lipoprotein
G4Q83_RS17005	COG0673	inositol 2-dehydrogenase activity
G4Q83_RS17010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G4Q83_RS17020	COG1090	epimerase
G4Q83_RS17090	COG4772	TonB-dependent receptor
G4Q83_RS17140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Q83_RS17140	COG1042	CoA-binding domain protein
G4Q83_RS17140	COG0045	succinate-CoA ligase (ADP-forming) activity
G4Q83_RS17175	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G4Q83_RS17240	COG0367	asparagine synthase
G4Q83_RS17275	COG1132	(ABC) transporter
G4Q83_RS17300	COG0531	amino acid
G4Q83_RS17315	COG5297	Belongs to the glycosyl hydrolase family 6
G4Q83_RS17315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G4Q83_RS17320	COG0612	Peptidase, M16
G4Q83_RS17370	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G4Q83_RS17410	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
G4Q83_RS17415	COG2207	Transcriptional regulator
G4Q83_RS17425	COG0598	Magnesium transport protein CorA
G4Q83_RS17430	COG1113	amino acid transport
G4Q83_RS17435	COG0697	spore germination
G4Q83_RS17455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4Q83_RS17485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4Q83_RS17490	COG0134	indole-3-glycerol-phosphate synthase activity
G4Q83_RS17525	COG0067	glutamate synthase
G4Q83_RS17525	COG0069	glutamate synthase activity
G4Q83_RS17525	COG0070	glutamate synthase
G4Q83_RS17530	COG0493	'glutamate synthase
G4Q83_RS17590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4Q83_RS17595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G4Q83_RS17595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G4Q83_RS17630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4Q83_RS17670	COG1309	transcriptional regulator
G4Q83_RS17690	COG4948	Mandelate Racemase Muconate Lactonizing
G4Q83_RS17695	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Q83_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS17715	COG0546	phosphoglycolate phosphatase activity
G4Q83_RS17725	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS17740	COG1024	Enoyl-CoA hydratase
G4Q83_RS17770	COG0710	3-dehydroquinate dehydratase activity
G4Q83_RS17780	COG3420	alginic acid biosynthetic process
G4Q83_RS17785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4Q83_RS17815	COG0714	Associated with various cellular activities
G4Q83_RS17840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_RS17845	COG2130	NADP-dependent
G4Q83_RS17860	COG1187	pseudouridine synthase activity
G4Q83_RS17875	COG1643	Atp-dependent helicase
G4Q83_RS17895	COG2050	protein possibly involved in aromatic compounds catabolism
G4Q83_RS17900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4Q83_RS17910	COG2062	phosphohistidine phosphatase, SixA
G4Q83_RS17915	COG1192	Involved in chromosome partitioning
G4Q83_RS17920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Q83_RS17955	COG4221	oxidoreductase activity
G4Q83_RS17960	COG0583	DNA-binding transcription factor activity
G4Q83_RS17980	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS18000	COG3093	addiction module antidote protein HigA
G4Q83_RS18005	COG3549	Plasmid maintenance system killer
G4Q83_RS18010	COG1205	dead DEAH box helicase
G4Q83_RS18010	COG1111	helicase
G4Q83_RS18085	COG0339	signal peptide processing
G4Q83_RS18125	COG2911	Protein conserved in bacteria
G4Q83_RS18130	COG0729	surface antigen
G4Q83_RS18160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Q83_RS18165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_RS18170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4Q83_RS18175	COG3485	protocatechuate 3,4-dioxygenase
G4Q83_RS18180	COG3485	protocatechuate 3,4-dioxygenase
G4Q83_RS18190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4Q83_RS18215	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS18225	COG2885	chlorophyll binding
G4Q83_RS18260	COG0501	Belongs to the peptidase M48B family
G4Q83_RS18265	COG1266	CAAX protease self-immunity
G4Q83_RS18270	COG0187	DNA topoisomerase II activity
G4Q83_RS18275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Q83_RS18300	COG0706	membrane insertase activity
G4Q83_RS18315	COG0582	viral genome integration into host DNA
G4Q83_RS18325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4Q83_RS18335	COG0732	type I restriction modification DNA specificity domain
G4Q83_RS18340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4Q83_RS18405	COG3186	Phenylalanine-4-hydroxylase
G4Q83_RS18410	COG1522	sequence-specific DNA binding
G4Q83_RS18430	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4Q83_RS18445	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_RS18460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4Q83_RS18485	COG1322	Protein conserved in bacteria
G4Q83_RS18490	COG2853	Lipoprotein
G4Q83_RS18505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4Q83_RS18510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4Q83_RS18515	COG1127	ABC transporter
G4Q83_RS18525	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS18535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G4Q83_RS18540	COG1074	ATP-dependent DNA helicase activity
G4Q83_RS18565	COG1119	ATPase activity
G4Q83_RS18585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4Q83_RS18600	COG0753	catalase activity
G4Q83_RS18605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4Q83_RS18610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4Q83_RS18635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Q83_RS18680	COG1294	oxidase, subunit
G4Q83_RS18685	COG1271	oxidase subunit
G4Q83_RS18700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Q83_RS18705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4Q83_RS18710	COG0408	coproporphyrinogen oxidase activity
G4Q83_RS18715	COG2323	membrane
G4Q83_RS18740	COG0589	response to stress
G4Q83_RS18760	COG0183	Belongs to the thiolase family
G4Q83_RS18795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G4Q83_RS18800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4Q83_RS18830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4Q83_RS18840	COG0612	Peptidase, M16
G4Q83_RS18850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Q83_RS18855	COG3177	Filamentation induced by cAMP protein fic
G4Q83_RS18865	COG0596	Alpha beta hydrolase
G4Q83_RS18870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Q83_RS18880	COG0727	PFAM Uncharacterised protein family (UPF0153)
G4Q83_RS18895	COG0318	PFAM AMP-dependent synthetase and ligase
G4Q83_RS18900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Q83_RS18910	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4Q83_RS18990	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_RS19045	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G4Q83_RS19050	COG3791	Glutathione-dependent formaldehyde-activating
G4Q83_RS19100	COG0583	DNA-binding transcription factor activity
G4Q83_RS19120	COG0697	spore germination
G4Q83_RS19130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Q83_RS19200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4Q83_RS19205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Q83_RS19210	COG1609	Transcriptional regulator
G4Q83_RS19220	COG2188	Transcriptional regulator
G4Q83_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS19245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4Q83_RS19285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4Q83_RS19285	COG1565	acr, cog1565
G4Q83_RS19295	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G4Q83_RS19345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4Q83_RS19405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4Q83_RS19470	COG4807	Protein conserved in bacteria
G4Q83_RS19495	COG5001	Diguanylate cyclase
G4Q83_RS19495	COG4251	negative regulation of phosphorylation
G4Q83_RS19495	COG3706	GGDEF domain
G4Q83_RS19495	COG2203	Gaf domain
G4Q83_RS19535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4Q83_RS19560	COG2032	superoxide dismutase activity
G4Q83_RS19565	COG2032	superoxide dismutase activity
G4Q83_RS19595	COG2204	response regulator
G4Q83_RS19600	COG3852	Histidine kinase
G4Q83_RS19605	COG0004	ammonium transporteR
G4Q83_RS19610	COG0347	Belongs to the P(II) protein family
G4Q83_RS19615	COG0174	glutamine synthetase
G4Q83_RS19655	COG0251	oxidation-reduction process
G4Q83_RS19670	COG1414	Transcriptional regulator
G4Q83_RS19690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Q83_RS19720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4Q83_RS19740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Q83_RS19745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G4Q83_RS19750	COG2201	protein-glutamate methylesterase activity
G4Q83_RS19755	COG2177	Part of the ABC transporter FtsEX involved in
G4Q83_RS19760	COG2884	Cell division ATP-binding protein ftsE
G4Q83_RS19770	COG3118	belongs to the thioredoxin family
G4Q83_RS19775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4Q83_RS19795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Q83_RS19845	COG1518	maintenance of DNA repeat elements
G4Q83_RS19850	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
G4Q83_RS19860	COG1652	LysM domain
G4Q83_RS19875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_RS19880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Q83_RS19895	COG5383	Protein conserved in bacteria
G4Q83_RS19945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4Q83_RS20060	COG0180	Tryptophanyl-tRNA synthetase
G4Q83_RS20085	COG0697	spore germination
G4Q83_RS20115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4Q83_RS20130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Q83_RS20145	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS20180	COG1252	NADH dehydrogenase
G4Q83_RS20200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4Q83_RS20210	COG0534	Mate efflux family protein
G4Q83_RS20215	COG0616	signal peptide processing
G4Q83_RS20230	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS20245	COG0009	L-threonylcarbamoyladenylate synthase
G4Q83_RS20250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Q83_RS20250	COG1754	DNA topoisomerase type I activity
G4Q83_RS20255	COG1714	RDD family
G4Q83_RS20270	COG0758	DNA mediated transformation
G4Q83_RS20275	COG1652	LysM domain
G4Q83_RS20280	COG0242	peptide deformylase activity
G4Q83_RS20290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4Q83_RS20290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4Q83_RS20295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4Q83_RS20310	COG0463	Glycosyl transferase, family 2
G4Q83_RS20330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4Q83_RS20360	COG0025	NhaP-type Na H and K H
G4Q83_RS20365	COG1131	(ABC) transporter
G4Q83_RS20370	COG0842	Transport permease protein
G4Q83_RS20385	COG1404	Belongs to the peptidase S8 family
G4Q83_RS20400	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS20425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4Q83_RS20450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_RS20460	COG4953	penicillin-binding protein 1C
G4Q83_RS20490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4Q83_RS20500	COG0028	Belongs to the TPP enzyme family
G4Q83_RS20515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4Q83_RS20530	COG3385	transposase activity
G4Q83_RS20540	COG4948	Mandelate Racemase Muconate Lactonizing
G4Q83_RS20550	COG4771	TonB-dependent receptor
G4Q83_RS20590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4Q83_RS20595	COG0366	Alpha amylase catalytic
G4Q83_RS20600	COG0366	Alpha amylase catalytic
G4Q83_RS20610	COG1609	Transcriptional regulator
G4Q83_RS20635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4Q83_RS20655	COG4221	oxidoreductase activity
G4Q83_RS20665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4Q83_RS20690	COG1199	ATP-dependent helicase activity
G4Q83_RS20735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4Q83_RS20745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4Q83_RS20755	COG0477	Major facilitator Superfamily
G4Q83_RS20760	COG0583	DNA-binding transcription factor activity
G4Q83_RS20765	COG0210	DNA helicase
G4Q83_RS20775	COG1289	transmembrane transporter activity
G4Q83_RS20780	COG2814	Major facilitator Superfamily
G4Q83_RS20815	COG2816	NAD+ diphosphatase activity
G4Q83_RS20860	COG1051	belongs to the nudix hydrolase family
G4Q83_RS20885	COG0708	Exodeoxyribonuclease III
G4Q83_RS20890	COG2814	Major facilitator Superfamily
G4Q83_RS20900	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G4Q83_RS20905	COG0739	heme binding
G4Q83_RS20910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4Q83_RS21030	COG2801	Transposase and inactivated derivatives
G4Q83_RS21045	COG0840	transmembrane signaling receptor activity
G4Q83_RS21050	COG3511	phospholipase C
G4Q83_RS21070	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS21085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4Q83_RS21125	COG0583	DNA-binding transcription factor activity
G4Q83_RS21130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4Q83_RS21130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Q83_RS21140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Q83_RS21150	COG2188	Transcriptional regulator
G4Q83_RS21210	COG2264	protein methyltransferase activity
G4Q83_RS21230	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G4Q83_RS21235	COG0138	bifunctional purine biosynthesis protein purh
G4Q83_RS21240	COG0151	Belongs to the GarS family
G4Q83_RS21250	COG0129	dihydroxy-acid dehydratase activity
G4Q83_RS21255	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_RS21280	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_RS21285	COG1879	ABC-type sugar transport system periplasmic component
G4Q83_RS21290	COG1129	ABC transporter
G4Q83_RS21295	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_RS21300	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_RS21355	COG0702	epimerase
G4Q83_RS21360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Q83_RS21365	COG1285	pathogenesis
G4Q83_RS21380	COG2354	Protein conserved in bacteria
G4Q83_RS21400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G4Q83_RS21405	COG1846	Transcriptional regulator
G4Q83_RS21410	COG1764	response to oxidative stress
G4Q83_RS21415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4Q83_RS21420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4Q83_RS21445	COG0583	DNA-binding transcription factor activity
G4Q83_RS21450	COG2814	Major facilitator Superfamily
G4Q83_RS21470	COG0745	RESPONSE REGULATOR receiver
G4Q83_RS21480	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_RS21520	COG0678	peroxiredoxin activity
G4Q83_RS21540	COG0604	alcohol dehydrogenase
G4Q83_RS21545	COG0330	HflC and HflK could
G4Q83_RS21550	COG0330	HflC and HflK could
G4Q83_RS21560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4Q83_RS21615	COG0358	DNA primase activity
G4Q83_RS21620	COG1295	ribonuclease BN
G4Q83_RS21640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4Q83_RS21645	COG2308	Evidence 4 Homologs of previously reported genes of
G4Q83_RS21660	COG2133	pyrroloquinoline quinone binding
G4Q83_RS21670	COG0531	amino acid
G4Q83_RS21705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4Q83_RS21720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4Q83_RS21725	COG0667	Aldo Keto reductase
G4Q83_RS21735	COG4771	TonB-dependent receptor
G4Q83_RS21780	COG2169	Transcriptional regulator
G4Q83_RS21780	COG1917	Cupin 2, conserved barrel domain protein
G4Q83_RS21790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G4Q83_RS21795	COG4181	ATPase activity
G4Q83_RS21810	COG0642	Histidine kinase
G4Q83_RS21820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G4Q83_RS21825	COG0861	Integral membrane protein TerC family
G4Q83_RS21830	COG1704	LemA family
G4Q83_RS21860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Q83_RS21865	COG2967	ApaG domain
G4Q83_RS21870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4Q83_RS21875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4Q83_RS21880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4Q83_RS21885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G4Q83_RS21895	COG2096	Adenosyltransferase
G4Q83_RS21905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Q83_RS21910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Q83_RS21930	COG0697	spore germination
G4Q83_RS21940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Q83_RS21950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4Q83_RS21960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4Q83_RS21965	COG0583	DNA-binding transcription factor activity
G4Q83_RS21970	COG3634	alkyl hydroperoxide reductase activity
G4Q83_RS21980	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Q83_RS22010	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_RS22045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Q83_RS22045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Q83_RS22085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G4Q83_RS22125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4Q83_RS22130	COG1404	Belongs to the peptidase S8 family
G4Q83_RS22135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4Q83_RS22270	COG1475	DNA binding
G4Q83_RS22310	COG4962	Type ii secretion system protein e
G4Q83_RS22325	COG3451	type IV secretory pathway VirB4
G4Q83_RS22370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone